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ursolic acid muscle

Soroush Alaghehband Bahrami, Nuredin Bakhtiari
We previously reported that Ursolic Acid (UA) ameliorates skeletal muscle performance through satellite cells proliferation and cellular energy status. In studying the potential role of the hypothalamus in aging, we developed a strategy to pursue UA effects on the hypothalamus anti-aging proteins such as; SIRT1, SIRT6, PGC-1β and α-Klotho. In this study, we used a model of aging animals (C57BL/6). UA dissolved in Corn oil (20mg/ml) and then administrated (200mg/Kg i.p injection) to mice, twice daily for 7days...
August 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
David D Church, Neil A Schwarz, Mike B Spillane, Sarah K McKinley-Barnard, Tom L Andre, Alejandro J Ramirez, Darryn S Willoughby
OBJECTIVE: Ursolic acid administration following resistance exercise increases mammalian target of rapamycin complex 1 (mTORC1) activity and skeletal muscle IGF-1 concentration in murines in a manner similar to l-leucine yet remains unexamined in humans. This study examined serum and skeletal muscle insulin-like growth factor-1 (IGF-1) and Akt/mTORC1 signaling activity following ingestion of either ursolic acid or l-leucine immediately after resistance exercise. METHODS: Nine resistance-trained men performed 3 lower-body resistance exercise sessions involving 4 sets of 8-10 repetitions at 75%-80% one repetition maximum (1-RM) on the angled leg press and knee extension exercises...
June 22, 2016: Journal of the American College of Nutrition
Arjunan Sundaresan, Thangaiyan Radhiga, Kodukkur Viswanathan Pugalendi
The aim of this present study was to investigate the effect of ursolic acid (UA) and rosiglitazone (RSG) on insulin sensitivity and proximal insulin signaling pathways in high-fat diet (HFD)-fed C57/BL/6J mice. Male C57BL/6J mice were fed either normal diet or HFD for 10 weeks, after which animals in each dietary group were divided into the following six groups (normal diet, normal diet plus UA and RSG, HFD alone, HFD plus UA, HFD plus RSG, and HFD plus UA and RSG) for the next 5 weeks. UA (5 mg/kg BW) and RSG (4 mg/kg BW) were administered as suspensions directly into the stomach using a gastric tube...
June 2016: Journal of Physiology and Biochemistry
Qixiao Jiang, Yantao Han, Hui Gao, Rong Tian, Ping Li, Chunbo Wang
This study focused on the anti-proliferation effects of ursolic acid (UA) in rat primary vascular smooth muscle cells (VSMCs) and investigated underlying molecular mechanism of action. Rat primary VSMCs were pretreated with UA (10, 20 or 30μM) or amino guanidine (AG, 50μM) for 12h or with PI3K inhibitor LY294002 for 30min or with Akt inhibitor MK2206 for 24h, then 10% fetal bovine serum was used to induce proliferation. CCK-8 was used to assess cell proliferation. To explore the mechanism, cells were treated with UA (10, 20 or 30μM), LY294002 or MK2206, or transient transfected to inhibit miRNA-21 (miRNA-21) or to overexpress PTEN, then quantitative real-time PCR was used to assess the mRNA levels of miRNA-21 and phosphatase and tensin homolog (PTEN) for cells treated with UA or miRNA-21 inhibitor; western blotting was used to measure the protein levels of PTEN and PI3K...
June 15, 2016: European Journal of Pharmacology
Nuredin Bakhtiari, Saman Hosseinkhani, Masoud Soleimani, Roohullah Hemmati, Ali Noori-Zadeh, Mohammad Javan, Amin Tashakor
Ursolic acid (UA) is a triterpenoid compound, which exerts its influences on the skeletal muscles. However, the mechanisms underlying these effects are still unclear. In this study, muscle satellite cells were isolated and purified by high-throughput pre-plating method (∼>60%) from 10 days old mice skeletal muscles. Evaluation of paired-box 7 (Pax7) expressions then confirmed the purification. Treatment of the cells with UA showed that UA up-regulated SIRT1 (∼35 folds) and overexpressed PGC-1α (∼175 folds) gene significantly...
March 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
G L Close, D L Hamilton, A Philp, L M Burke, J P Morton
Despite over 50 years of research, the field of sports nutrition continues to grow at a rapid rate. Whilst the traditional research focus was one that centred on strategies to maximise competition performance, emerging data in the last decade has demonstrated how both macronutrient and micronutrient availability can play a prominent role in regulating those cell signalling pathways that modulate skeletal muscle adaptations to endurance and resistance training. Nonetheless, in the context of exercise performance, it is clear that carbohydrate (but not fat) still remains king and that carefully chosen ergogenic aids (e...
September 2016: Free Radical Biology & Medicine
Jin Tao, Yuanyuan Hou, Xiaoyao Ma, Dan Liu, Yongling Tong, Hong Zhou, Jie Gao, Gang Bai
BACKGROUND: Traditional Chinese medicine (TCM) herbal formulae provide valuable therapeutic strategies. However, the active ingredients and mechanisms of action remain unclear for most of these formulae. Therefore, the identification of complex mechanisms is a major challenge in TCM research. METHODS: This study used a network pharmacology approach to clarify the anti-inflammatory and cough suppressing mechanisms of the Chinese medicinal preparation Eriobotrya japonica - Fritillaria usuriensis dropping pills (ChuanbeiPipa dropping pills, CBPP)...
2016: BMC Complementary and Alternative Medicine
Fabiano B Carvalho, Aline A Boligon, Margareth L Athayde, Maribel A Rubin, Juliano Ferreira, Gabriela Trevisan
ETHNOPHARMACOLOGICAL RELEVANCE: Scutia buxifolia is a tree native to South America and is used as a cardiotonic agent; however, this property has not been associated with a clear mechanism or a specific compound. AIM OF THE STUDY: Given the importance of Na(+),K(+)-ATPase as a drug target in the treatment of heart failure, this study aimed to investigate the possible inhibitory effect of S. buxifolia crude extract and fractions (dichloromethane, ethyl acetate, and butanolic fractions), and identified compounds with effects on the activity of Na(+),K(+)-ATPase in vitro...
February 17, 2016: Journal of Ethnopharmacology
Łukasz Woźniak, Sylwia Skąpska, Krystian Marszałek
Ursolic acid (UA) is a natural terpene compound exhibiting many pharmaceutical properties. In this review the current state of knowledge about the health-promoting properties of this widespread, biologically active compound, as well as information about its occurrence and biosynthesis are presented. Particular attention has been paid to the application of ursolic acid as an anti-cancer agent; it is worth noticing that clinical tests suggesting the possibility of practical use of UA have already been conducted...
2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Scott M Ebert, Michael C Dyle, Steven A Bullard, Jason M Dierdorff, Daryl J Murry, Daniel K Fox, Kale S Bongers, Vitor A Lira, David K Meyerholz, John J Talley, Christopher M Adams
Aging reduces skeletal muscle mass and strength, but the underlying molecular mechanisms remain elusive. Here, we used mouse models to investigate molecular mechanisms of age-related skeletal muscle weakness and atrophy as well as new potential interventions for these conditions. We identified two small molecules that significantly reduce age-related deficits in skeletal muscle strength, quality, and mass: ursolic acid (a pentacyclic triterpenoid found in apples) and tomatidine (a steroidal alkaloid derived from green tomatoes)...
October 16, 2015: Journal of Biological Chemistry
Ji-Woong Jeong, Jae-Jung Shim, Il-Dong Choi, Sung-Hwan Kim, Jehyeon Ra, Hyung Keun Ku, Dong Eun Lee, Tae-Youl Kim, Woonhee Jeung, Jung-Hee Lee, Ki Won Lee, Chul-Sung Huh, Jae-Hun Sim, Young-Tae Ahn
Ursolic acid is a lipophilic pentacyclic triterpenoid found in many fruits and herbs and is used in several herbal folk medicines for diabetes. In this study, we evaluated the effects of apple pomace extract (APE; ursolic acid content, 183 mg/g) on skeletal muscle atrophy. To examine APE therapeutic potential in muscle atrophy, we investigated APE effects on the expression of biomarkers associated with muscle atrophy and hypertrophy. We found that APE inhibited atrophy, while inducing hypertrophy in C2C12 myotubes by decreasing the expression of atrophy-related genes and increasing the expression of hypertrophy-associated genes...
December 2015: Journal of Medicinal Food
Kyung Kyun Noh, Ki Wung Chung, Bokyung Sung, Min Jo Kim, Chan Hum Park, Changshin Yoon, Jae Sue Choi, Mi Kyung Kim, Cheol Min Kim, Nam Deuk Kim, Hae Young Chung
In the Orient, loquat (Eriobotrya japonica) extract (LE) is widely used in teas, food and folk medicines. The leaves of the loquat tree have been used for generations to treat chronic bronchitis, coughs, phlegm production, high fever and gastroenteric disorders. One of the major active components of loquat leaves is ursolic acid, which was recently investigated in the context of preventing muscle atrophy. The present study investigated the therapeutic potential of LE on dexamethasone‑induced muscle atrophy in rats...
September 2015: Molecular Medicine Reports
Qin Li, Ying-sai Fan, Zong-qin Gao, Kai Fan, Zhong-jie Liu
UNLABELLED: Fructus Ligustri Lucidi, fruits of Ligustrum lucidum Ait. (Oleaceae), has the effects of tonifying the liver and the kidney and strengthening the bones and muscles. In ancient times, Fructus Ligustri Lucidi can be prepared in ethanol or in water. Some active compounds have been found in Fructus Ligustri Lucidi, like Oleanolic acid and Ursolic acid, and Ursolic acid were proved to have osteogenic effects. METHODS AND RESULTS: To prove that Fructus Ligustri Lucidi water extract have osteogenic effects on MC3T3-E1 cells and how these effects work, we used CCK-8 (cell counting kit-8), ELISA (enzyme-linked immunosorbent assay), FQ-PCR (realtime fluorescence quantitative PCR) and western blot assays...
July 21, 2015: Journal of Ethnopharmacology
Nuredin Bakhtiari, Saman Hosseinkhani, Amin Tashakor, Roohullah Hemmati
Ursolic acid (UA) is a lipophilic compound, which highly found in apple peels. UA has some certain features, of the most important is its anabolic effects on skeletal muscles, which in turn plays a prominent role in the aging process, encouraged us to evaluate skeletal muscle rejuvenation. This study seeks to address the two following questions: primarily, we wonder to know if UA increases anti-aging biomarkers (SIRT1 and PGC-1α) in the isolated satellite cells, to pave the way for satellite cells proliferation...
July 2015: Medical Hypotheses
Natalia Prissadova, Petko Bozov, Kiril Marinkov, Hristo Badakov, Atanas Kristev
Ursolic acid (UA) in concentrations of l x 10(7) mol/L - 5 x 10(5) mol/L induced relaxation in gastric smooth muscle (SM) tissues, in a concentration-dependent manner. The relaxation did not change membrane potential and slow wave contraction patterns. A significant decrease in amplitude and frequency of spike- potentials was observed. UA-induced reactivity was removed when SM preparations were treated with nifedipine (1 x 10(6) mol/L). Ca2+-induced contractions of the depolarized SM preparations (42 mmol/L K+; Ca2+-free Krebs solution) were substantially reduced in the presence of UA...
April 2015: Natural Product Communications
Xia Chu, Xuan He, Zhiping Shi, Chunjuan Li, Fuchuan Guo, Songtao Li, Ying Li, Lixin Na, Changhao Sun
SCOPE: Ursolic acid (UA) is a triterpenoid compound with multifold biological functions. Our previous studies have reported that UA protects against high-fat diet-induced obesity and improves insulin resistance (IR). However, the potential mechanisms are still undefined. Free fatty acid (FFA) metabolism in skeletal muscle plays a central role in obesity and IR. Therefore, in this study, we investigated the effect and the potential mechanisms of UA on skeletal muscle FFA metabolism. METHODS AND RESULTS: In diet-induced obese rats, 0...
August 2015: Molecular Nutrition & Food Research
Hua Xu, Min Zhang, Xiao-Li Li, Heng Li, Long-Tao Yue, Xin-Xin Zhang, Cong-Cong Wang, Shan Wang, Rui-Sheng Duan
Myasthenia gravis (MG) is an autoimmune disease characterized by fatigable muscle weakness. Ursolic acid (UA) is a pentacyclic triterpenoid with anti-inflammatory and immunomodulatory properties, especially inhibiting IL-17. We found that UA ameliorated the symptoms of experimental autoimmune myasthenia gravis (EAMG), a rat model of MG. Although both the low and high doses of UA shifted Th17 to Th2 cytokines, other mechanisms were dose dependent. The low dose enhanced Fas-mediated apoptosis, whereas the high dose up-regulated Treg cells and reduced the concentrations of IgG2b antibodies...
April 15, 2015: Journal of Neuroimmunology
Christopher M Adams, Scott M Ebert, Michael C Dyle
PURPOSE OF REVIEW: Here, we discuss a recently developed experimental strategy for discovering small molecules with potential to prevent and treat skeletal muscle atrophy. RECENT FINDINGS: Muscle atrophy involves and requires widespread changes in skeletal muscle gene expression, which generate complex but measurable patterns of positive and negative changes in skeletal muscle mRNA levels (a.k.a. mRNA expression signatures of muscle atrophy). Many bioactive small molecules generate their own characteristic mRNA expression signatures, and by identifying small molecules whose signatures approximate mirror images of muscle atrophy signatures, one may identify small molecules with potential to prevent and/or reverse muscle atrophy...
May 2015: Current Opinion in Clinical Nutrition and Metabolic Care
Hyun Seok Bang, Dae Yun Seo, Yong Min Chung, Kyoung-Mo Oh, Jung Jun Park, Figueroa Arturo, Seung-Hun Jeong, Nari Kim, Jin Han
[This corrects the article on p. 441 in vol. 18, PMID: 25352765.].
December 2014: Korean Journal of Physiology & Pharmacology
Minjung Kim, Bokyung Sung, Yong Jung Kang, Dong Hwan Kim, Yujin Lee, Seong Yeon Hwang, Jeong-Hyun Yoon, Mi-Ae Yoo, Cheol Min Kim, Hae Young Chung, Nam Deuk Kim
Aging causes phenotypic changes in skeletal muscle progenitor cells that lead to the progressive loss of myogenic differentiation and thus a decrease in muscle mass. The naturally occurring triterpene, ursolic acid, has been reported to be an effective agent for the prevention of muscle loss by suppressing degenerative muscular dystrophy. Leucine, a branched-chain amino acid, and its metabolite, β-hydroxy-β-methylbutyric acid, have been reported to enhance protein synthesis in skeletal muscle. Therefore, the aim of the present study was to investigate whether the combination of ursolic acid and leucine promotes greater myogenic differentiation compared to either agent alone in C2C12 murine myoblasts...
March 2015: International Journal of Molecular Medicine
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