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https://www.readbyqxmd.com/read/27890169/hepatitis-c-virus-infection-and-rheumatic-diseases-the-impact-of-direct-acting-antiviral-agents
#1
REVIEW
Patrice Cacoub, Cloé Commarmond, David Sadoun, Anne Claire Desbois
Chronic hepatitis C virus (HCV) infection is associated with liver and extrahepatic complications, including B-cell lymphoma, cardiovascular and kidney diseases, glucose metabolism impairment and rheumatic conditions ie, arthralgia, myalgia, cryoglobulinemia vasculitis, sicca syndrome and the production of autoantibodies. The treatment has long been based on interferon alpha (IFN) that was found poorly effective, and contraindicated in many autoimmune/inflammatory disorders because of possible exacerbation of rheumatic disorders...
February 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/27723989/-extrahepatic-manifestations-of-hcv-infection
#2
Petr Husa
Extrahepatic manifestations of hepatitis C virus infection (HCV) are very common. The most common of these is mixed cryoglobulinaemia. Anti-HCV antibodies and viral ribonucleic acid, HCV RNA, can be found in the cryoprecipitates, together with the rheumatoid factor. Cryoglobulins consist of a complex of immunoglobulins that in vitro precipitate upon the cooling bellow the human body temperature. Vasculitis is caused by the deposition of such immune complexes in the small blood vessels. A link with the HCV infection is considered to be established with membranoproliferative glomerulonephritis, leukocytoclastic vasculitis, lymphoproliferative disorders (in particular B cell lymphoma), Sjögren and sicca syndrome, lichen planus, porfyria cutanea tarda and diabetes mellitus...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27640316/international-diagnostic-guidelines-for-patients-with-hcv-related-extrahepatic-manifestations-a-multidisciplinary-expert-statement
#3
Clodoveo Ferri, Manuel Ramos-Casals, Anna Linda Zignego, Luca Arcaini, Dario Roccatello, Alessandro Antonelli, David Saadoun, Anne Claire Desbois, Marco Sebastiani, Milvia Casato, Peter Lamprecht, Alessandra Mangia, Athanasios G Tzioufas, Zobair M Younossi, Patrice Cacoub
Hepatitis C virus (HCV) infection is responsible for both hepatic and extra-hepatic disorders (HCV-EHDs); these latter are correlated on one hand clearly with HCV lymphotropism causing immune-system dysregulation as well as with viral oncogenic potential, and on the other hand probably with chronic inflammatory status causing cardio-metabolic complications as well as neurocognitive disturbances. The spectrum of HCV-EHDs ranges from mild or moderate manifestations, such as arthralgia, sicca syndrome, peripheral neuropathy, to severe, life-threatening complications, mainly vasculitis and neoplastic complications...
September 16, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/26819509/rheumatic-manifestations-of-hepatitis-c-virus-chronic-infection-indications-for-a-correct-diagnosis
#4
REVIEW
Carlo Palazzi, Emilio D'Amico, Salvatore D'Angelo, Michele Gilio, Ignazio Olivieri
Hepatitis C virus (HCV) is a hepato- and lymphotropic agent that is able to induce several autoimmune rheumatic disorders: vasculitis, sicca syndrome, arthralgias/arthritis and fibromyalgia. The severity of clinical manifestations is variable and sometimes life-threatening. HCV infection can mimic many primitive rheumatic diseases, therefore, it is mandatory to distinguish HCV-related manifestations from primitive ones because the prognosis and therapeutic strategies can be fairly dissimilar. The new direct-acting antivirals drugs can help to avoid the well-known risks of worsening or new onset of autoimmune diseases during the traditional interferon-based therapies...
January 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26343108/hcv-related-rheumatic-manifestations-and-therapeutic-strategies
#5
Marco Sebastiani, Dilia Giuggioli, Michele Colaci, Poupak Fallahi, Laura Gragnani, Alessandro Antonelli, Anna Linda Zignego, Clodoveo Ferri
A number of hepatic and extra-hepatic autoimmune disorders may complicate a percentage of patients with hepatitis C virus (HCV) infection that is both hepatotropic and lymphotropic agent; the resulting clinical phenotypes can be grouped into the so-called HCV syndrome. This latter includes various rheumatic disorders that are frequently characterized by clinical or serological overlap; thus, a correct patients' classification is necessary prior to decide the therapy. The management of these conditions is particularly difficult, given the coexistence of viral infection and immunological alterations...
September 6, 2015: Current Drug Targets
https://www.readbyqxmd.com/read/26284256/neisseria-sicca-endocarditis-presenting-as-multiple-embolic-brain-infarcts
#6
Christine Kirlew, Kobina Wilmot, Jorge L Salinas
A 58 year old male presented with a 14 day history of progressive forgetfulness and aggressiveness. He had a history of human immunodeficiency virus infection, ischemic cardiomyopathy, and a myxomatous mitral valve (status post Saint Jude's mitral valve replacement 8 years before presentation). International normalized ratio was supra-therapeatutic on admission. A non-contrast computed tomography of the brain indicated multiple infarcts with hemorrhagic conversion. The source was later found to be a rare case of Neisseria sicca endocarditis...
September 2015: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/26208812/extrahepatic-manifestations-of-hepatitis-c-infection-navigating-chasm
#7
REVIEW
Amy C Sherman, Kenneth E Sherman
This article describes the importance of extrahepatic systemic manifestations of chronic hepatitis C virus (HCV) infection. While most HCV literature focuses on liver injury and fibrosis progression, a spectrum of systemic disease processes, collectively called C hepatitis-associated systemic manifestations (CHASMs), are present in a high proportion of infected persons. These include thyroid disease (Hashimoto's thyroiditis, Graves disease, and thyroid cancer), cardiovascular disease (atherosclerosis, carotid artery disease, and coronary artery disease), renal disease (MPGN and glomerulosclerosis), eye disease (Mooren's ulcers and sicca syndrome), skin disease (PCT, vasculitis, and lichen planus), lymphomas (NHL and splenic T-cell), and diabetes...
September 2015: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/25848147/sicca-syndrome-and-dementia-in-a-patient-with-hepatitis-c-infection-a-case-report-with-unusual-bifocal-extrahepatic-manifestations
#8
R H Khonsari, S Maylin, P Nicol, M Martinot-Peignoux, A Créange, C Duyckaerts, C Bertolus
INTRODUCTION: Hepatitis C virus (HCV) infections are associated with extrahepatic manifestations in 40-75 % of cases. Sialitis and secondary Sjögren syndrome are well characterized complications of chronic HCV infections but the mechanisms (primary or secondary) leading to xerostomia are not understood. Similarly, brain lesions due to HCV can be primary or secondary but the pathology of primary HCV-related brain lesions is not well described. CASE REPORT: We report the postmortem case of a 60-year old patient initially presenting with sicca syndrome and dementia...
March 2015: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/25755502/hepatotropic-viral-infection-associated-systemic-vasculitides-hepatitis-b-virus-associated-polyarteritis-nodosa-and-hepatitis-c-virus-associated-cryoglobulinemic-vasculitis
#9
REVIEW
Aman Sharma, Kusum Sharma
Two hepatotropic viruses have been shown to have causal relationship with systemic vasculitis-hepatitis B with classical polyarteritis nodosa and hepatitis C with cryoglobulinemic vasculitis. The present paper provides an updated overview on the clinical presentations and management of these vasculitides. HBV associated PAN patients have higher weight loss, peripheral neuropathy, mononeuritis multiplex, abdominal pain, gastrointestinal manifestations requiring surgery, cardiomyopathy, orchitis, hypertension, and/or elevated transaminase levels...
September 2013: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/25533738/magnetic-resonance-sialography-of-the-parotid-glands-in-chronic-hepatitis-c-virus-patients-with-and-without-vasculitis
#10
Amira A Shahin, Hanan Hussein, Wafaa Gaber, Tamer Elbaz, Lamia A Salah El Din
AIM: Hepatitis C virus (HCV) is sialotropic. The pathogenesis of sicca manifestations in patients with chronic HCV infection is not fully understood. We aimed to detect changes in magnetic resonance sialography (MRS) of HCV patients with and without vasculitis. METHOD: We studied 32 HCV patients (19 female, mean age 48.8 ± 10.3 years) and 20 age- and gender-matched healthy controls. Half of the patients had vasculitis. Demographic, clinical and serological data were prospectively evaluated...
December 23, 2014: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/25340658/a-case-of-hiv-associated-diffuse-infiltrative-lymphocytosis-syndrome-simulating-primary-sj%C3%A3-gren-syndrome-and-balt-lymphoma
#11
João Rovisco, Tânia Santiago, Luís Inês
Diffuse infiltrative lymphocytic syndrome is a clinical identity that can be part of the spectrum of Human Immunodeficiency Virus infection. It is characterized by sicca symptoms, parotid and lachrymal enlargement and extra-articular manifestations. We report the case of a 60 years old woman with clinical sicca syndrome in association with leukopenia, positive anti-nuclear antibody (ANA) and polyclonal hypergammaglobulinemia. In the follow up the patient developed a mucosa-associated lymphoid tissue pulmonary neoplasm...
January 2015: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/25340428/inflammatory-manifestations-of-htlv-1-and-their-therapeutic-options
#12
REVIEW
Fabiola Martin, Graham P Taylor, Steven Jacobson
Human T lymphotropic virus type 1 (HTLV-1) is one of the most intriguing retroviruses infecting humans. Most commonly, infection remains undetected, since it does not cause obvious harm, yet in 4-9% of patients, this infection can be devastating, causing adult T-cell leukemia/lymphoma and/or HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). This review concentrates on all inflammatory aspects of HTLV-1 infection: HAM/TSP, HTLV-1 associated uveitis, HTLV-1 associated conjunctivitis, sicca syndrome and interstitial keratitis, HTLV-1 associated Sjögren's syndrome, Hashimoto's thyroiditis and Graves' disease, HTLV-1 associated pulmonary disease, infective dermatitis associated with HTLV-1, HTLV-1 associated inflammatory myositis and HTLV-1 associated arthritis...
November 2014: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/25263827/hepatitis-c-virus-infection-and-the-risk-of-sj%C3%A3-gren-or-sicca-syndrome-a-meta-analysis
#13
Yan Wang, Hengli Dou, Guowei Liu, Lili Yu, Shimin Chen, Yan Min, Kanghai Zhao, Xingjuan Wang, Chengjin Hu
Previous studies have suggested an association between hepatitis C virus (HCV) infection and the development of Sjögren's syndrome (SS), also known as sicca syndrome. The main objective of this study was to summarize the existing evidence and quantitatively evaluate the association between hepatitis C virus infection and SS/sicca syndrome by performing a meta-analysis of observational studies. MEDLINE and PubMed (January 1980-August 2013) were searched to identify relevant studies in English. Outcomes were calculated and are reported as odds risk (OR) and 95% CIs based on a random-effects model...
December 2014: Microbiology and Immunology
https://www.readbyqxmd.com/read/24952023/the-differential-diagnosis-of-dry-eyes-dry-mouth-and-parotidomegaly-a-comprehensive-review
#14
REVIEW
Divi Cornec, Alain Saraux, Sandrine Jousse-Joulin, Jacques-Olivier Pers, Sylvie Boisramé-Gastrin, Yves Renaudineau, Yves Gauvin, Anne-Marie Roguedas-Contios, Steeve Genestet, Myriam Chastaing, Béatrice Cochener, Valérie Devauchelle-Pensec
Primary Sjögren's syndrome (pSS) is a frequent autoimmune systemic disease, clinically characterized by eyes and mouth dryness in all patients, salivary gland swelling or extraglandular systemic manifestations in half of the patients, and development of lymphoma in 5 to 10 % of the patients. However, patients presenting with sicca symptoms or salivary gland swelling may have a variety of conditions that may require very different investigations, treatments, or follow-up. Eye and/or mouth dryness is a frequent complaint in clinical setting, and its frequency increases with age...
December 2015: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/24774584/sj%C3%A3-gren-s-syndrome-another-facet-of-the-autoimmune-inflammatory-syndrome-induced-by-adjuvants-asia
#15
REVIEW
S Colafrancesco, C Perricone, R Priori, G Valesini, Y Shoenfeld
Recently, a new syndrome, namely the "Autoimmune/inflammatory syndrome induced by adjuvants" (ASIA) has been defined. In this syndrome different conditions characterized by common signs and symptoms and induced by the presence of an adjuvant are included. The adjuvant is a substance capable of boosting the immune response and of acting as a trigger in the development of autoimmune diseases. Post-vaccination autoimmune phenomena represent a major issue of ASIA. Indeed, despite vaccines represent a mainstay in the improvement of human health, several of these have been implicated as a potential trigger for autoimmune diseases...
June 2014: Journal of Autoimmunity
https://www.readbyqxmd.com/read/24709167/extrahepatic-manifestations-of-chronic-hepatitis-c-virus-infection-297-cases-from-a-tertiary-medical-center-in-beijing-china
#16
Zhaojing Cheng, Baotong Zhou, Xiaochun Shi, Yao Zhang, Lifan Zhang, Limeng Chen, Xiaoqing Liu
BACKGROUND: Chronic hepatitis C virus (HCV) infection can affect multiple organ systems and cause a variety of extrahepatic manifestations (EMs). We sought to assess the constituent ratio of EMs in Chinese patients with chronic HCV infection and identify the clinical and biological factors associated with EM. METHODS: The medical records of 297 patients with chronic HCV infection were analyzed and demographic and epidemiological information was collected. The diagnosis of chronic HCV infection was based on positive anti-HCV combined with a positive HCV-RNA or at least two times of elevated aminotransferases attributable to HCV infection...
2014: Chinese Medical Journal
https://www.readbyqxmd.com/read/24659887/useful-biomarkers-for-assessment-of-hepatitis-c-virus-infection-associated-autoimmune-disorders
#17
REVIEW
Deng-Ho Yang, Ling-Jun Ho, Jenn-Haung Lai
During the course of chronic hepatitis C virus (HCV) infection, various extrahepatic manifestations of autoimmune disorders may occur, including arthralgia/arthritis, sicca complex, purpura, cutaneous ulcer, and thyroid dysfunction. In addition, the prevalence of circulating autoantibodies is high among patients with HCV infection. Commonly detected autoantibodies in HCV-infected patients include rheumatoid factor, antinuclear antibody, anti-SSA/anti-SSB antibody, cryoglobulin, antineutrophil cytoplasmic antibody, anti-smooth muscle antibody, anti-liver and anti-thyroid autoantibodies...
March 21, 2014: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/24384002/sicca-syndrome-in-patients-infected-with-human-immunodeficiency-virus-1
#18
M Yamamoto, R Nakao, Y Higuchi, T Miyamura, E Suematsu
Abstract We investigated human immunodeficiency virus-1 (HIV-1)-associated sicca syndrome. The average saliva production in HIV-infected patients was 15.9 ± 6.3 ml, and the average tear production was 9.8 ± 4.5 mm. In particular, 6 patients (42.9%) showed a significant decrease in tear production. This sicca syndrome mimicked autoimmune Sjögren's syndrome (SS) because of the presence of dry eye, dry mouth, hyperamylasemia, and hypergammaglobulinemia; however, no antinuclear antibodies, anti-SS-A, or anti-SS-B were detected in sera from HIV-1-infected patients...
December 2002: Modern Rheumatology
https://www.readbyqxmd.com/read/24299547/corneal-sequestrum-in-a-dog-with-chronic-unilateral-keratoconjunctivitis-sicca
#19
Alexis J Dubin, Stefano Pizzirani, Gillian L Beamer
CASE DESCRIPTION: A 14-year-old 8.2-kg (18.04-lb) castrated male Cairn Terrier with chronic keratoconjunctivitis sicca in the left eye was evaluated because of severe blepharospasm and a black plaque of 3 weeks' duration. CLINICAL FINDINGS: Abnormalities of the left eye included a decreased Schirmer tear test value and the presence of a brownish-black plaque in the center of the cornea. The plaque was surrounded by fibrovascular tissue except at the medial aspect where there was mild malacia of the adjacent corneal stroma...
December 15, 2013: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/24223303/measuring-the-response-of-extrahepatic-symptoms-and-quality-of-life-to-antiviral-treatment-in-patients-with-hepatitis-c
#20
David Isaacs, Nader Abdelaziz, Majella Keller, Jeremy Tibble, Inam Haq
Background. HCV infection is associated with musculoskeletal manifestations such as chronic widespread pain, sicca syndrome, polyarthritis, and a reduced HRQOL. Little data is available on the effect of treatment on these manifestations. This study measured changes in extrahepatic symptoms and HRQOL before and after antiviral treatment in a large UK patient cohort. Methods. 118 patients completed HQLQ and rheumatological questionnaires before and after treatment with pegylated interferon- α and ribavirin, with specific regard to chronic widespread pain, sicca syndrome, and sustained virological response...
2013: Hepatitis Research and Treatment
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