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https://www.readbyqxmd.com/read/28351127/absorption-amelioration-of-amorphous-si-film-by-introducing-metal-silicide-nanoparticles
#1
Hui Sun, Hsuan-Chung Wu, Sheng-Chi Chen, Che-Wei Ma Lee, Xin Wang
Amorphous Si (a-Si) films with metal silicide are expected to enhance the absorption ability of pure a-Si films. In this present study, NiSi (20 nm)/Si (40 nm) and AlSi (20 nm)/Si (40 nm) bilayer thin films are deposited through radio frequency (RF) sputtering at room temperature. The influence of the film's composition and the annealing temperature on the film's optical absorption is investigated. The results show that all the NiSi/Si films and AlSi/Si films possess higher absorption ability compared to a pure a-Si film (60 nm)...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28351118/how-will-repealing-the-aca-affect-medicaid-impact-on-health-care-coverage-delivery-and-payment
#2
Sara Rosenbaum, Sara Rothenberg, Sara Schmucker, Rachel Gunsalus, J. Zoë Beckerman
ISSUE: The Affordable Care Act enhanced Medicaid's role as a health care purchaser by expanding eligibility and broadening the range of tools and strategies available to states. All states have embraced delivery and payment reform as basic elements of their programs. GOAL: To examine the effects of reducing the size and scope of Medicaid under legislation to repeal the ACA. FINDINGS AND CONCLUSIONS: Were the ACA's Medicaid expansion to be eliminated and were federal Medicaid funding to experience major reductions through block grants or per capita caps, the effects on system transformation would be significant...
March 2017: Issue Brief of the Commonwealth Fund
https://www.readbyqxmd.com/read/28351063/from-communication-skills-to-skillful-communication-a-longitudinal-integrated-curriculum-for-critical-care-medicine-fellows
#3
Amanda L Roze des Ordons, Christopher J Doig, Philippe Couillard, Jason Lord
PROBLEM: Communication with patients and families in critical care medicine (CCM) can be complex and challenging. A longitudinal curricular model integrating multiple techniques within classroom and clinical milieus may facilitate skillful communication across diverse settings. APPROACH: In 2014-2015, the authors developed and implemented a curriculum for CCM fellows at the Cumming School of Medicine, University of Calgary, to promote the longitudinal development of skillful communication...
April 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28351036/hypoxia-induces-multidrug-resistance-via-enhancement-of-epidermal-growth-factor-like-domain-7-expression-in-non-small-lung-cancer-cells
#4
Xiaochun Shen, Qiaoming Zhi, Yunliang Wang, Zhi Li, Jin Zhou, Jianan Huang
Chemotherapy is widely used in non-small cell lung cancer (NSCLC) treatment, yet multidrug resistance (MDR) is a major chemotherapeutic obstacle in both resectable and advanced NSCLC. Epidermal growth factor-like domain 7 (EGFL7), also known as vascular endothelial stain, is an endothelial cell-derived secreted factor that regulates vascular tube formulation. The aim of this study was to investigate the potential relationships between EGFL7 and MDR in NSCLC cells. We first obtained the CDDP-based MDR phenotype cell line A549/CDDP by repeated exposure to a proper concentration of CDDP (cisplatin) from original A549 cells...
March 29, 2017: Chemotherapy
https://www.readbyqxmd.com/read/28351020/optimization-of-a-new-methodology-for-trace-determination-of-elements-in-biological-fluids-application-for-speciation-of-inorganic-selenium-in-children-s-blood
#5
Reza Akramipour, Mitra Hemati, Nazir Fattahi, Meghdad Pirsaheb, Toraj Ahmadi-Jouibari
The continuous sample drop flow microextraction (CSDFME) joined with the iridium-modified tube graphite furnace atomic absorption spectrometry (GFAAS) has been developed as a highly sensitive technique for the speciation of selenium in blood samples. In this method 32.0μl carbon tetrachloride is transferred to the bottom of a conical sample cup. Then the 5.0ml of aqueous solution transforms to fine droplets while passing through the organic solvent. At this stage, Se(IV)-APDC hydrophobic complex is extracted into the organic solvent...
March 22, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28351011/fine-cutting-edge-shaped-bi2o3rods-reduced-graphene-oxide-rgo-composite-for-supercapacitor-and-visible-light-photocatalytic-applications
#6
D Maruthamani, S Vadivel, M Kumaravel, B Saravanakumar, Bappi Paul, Siddhartha Sankar Dhar, Aziz Habibi-Yangjeh, A Manikandan, Govindarajan Ramadoss
Bi2O3 rods/RGO composite has been synthesized by a simple precipitation and calcination method. The crystallnity, structural, and morphological features were studied by X-ray diffraction (XRD), field-emission scanning electron microscopy (FE-SEM), and high resolution transmission electron microscopy (HR-TEM) techniques. The supercapacitor behavior was studied using cyclic voltammetry, galvanostatic charge discharge and impedance analysis, respectively. The Bi2O3 rods/RGO nanocomposite exhibits a maximum specific capacitance of 1041Fg(-1) at a current density of 2Ag(-1)...
March 22, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28351007/catalytic-role-of-iron-in-the-formation-of-silver-nanoparticles-in-photo-irradiated-ag-dissolved-organic-matter-solution
#7
Yongguang Yin, Dan Han, Chao Tai, Zhiqiang Tan, Xiaoxia Zhou, Sujuan Yu, Jingfu Liu, Guibin Jiang
Photo-reduction of Ag(+) to silver nanoparticle (AgNPs) by dissolved organic matter (DOM) is a possible source of naturally occurring AgNPs. However, how this photo-reduction process is influenced by ubiquitous metal ions is still not well understood. In addition, in previous studies, the formation of AgNPs in DOM solution was usually monitored by UV-Vis spectroscopy, and there is still lack of quantitative analysis for the formed AgNPs. In the present study, the role of Fe(2+)/Fe(3+) at environmental concentration level on this photochemical process was investigated, and the enhanced formation of AgNPs by Fe(2+)/Fe(3+) was probed and quantified by using UV-Vis spectroscopy, transmission electron microscopy, and liquid chromatography-inductively coupled plasma mass spectrometry...
March 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28351005/nrf-2-driven-long-noncoding-rna-odrul-contributes-to-modulating-silver-nanoparticle-induced-effects-on-erythroid-cells
#8
Ming Gao, Beibei Zhao, Minjun Chen, Yun Liu, Ming Xu, Zhe Wang, Sijin Liu, Chengdong Zhang
The biosafety and biological effects of silver nanoparticles (AgNPs) on human health attract increasing concern. Although considerable studies have been performed to reveal the molecular mechanisms responsible for AgNP-induced effects, the current understanding mainly focuses on oxidative stress-associated signaling pathways activated by Ag particles and/or Ag ions. However, the molecular bases underlying the activation of these stress signaling pathways have not been thoroughly elucidated yet. In the current study, we aimed to shed light on the molecular bases of AgNP-induced effects on erythroid cells from the perspective of long noncoding RNAs...
March 22, 2017: Biomaterials
https://www.readbyqxmd.com/read/28351003/experimental-investigation-of-cognitive-and-affective-empathy-in-borderline-personality-disorder-effects-of-ambiguity-in-multimodal-social-information-processing
#9
Inga Niedtfeld
Borderline personality disorder (BPD) is characterized by affective instability and interpersonal problems. In the context of social interaction, impairments in empathy are proposed to result in inadequate social behavior. In contrast to findings of reduced cognitive empathy, some authors suggested enhanced emotional empathy in BPD. It was investigated whether ambiguity leads to decreased cognitive or emotional empathy in BPD. Thirty-four patients with BPD and thirty-two healthy controls were presented with video clips, which were presented through prosody, facial expression, and speech content...
March 23, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28351000/targeted-superparamagnetic-nanoparticles-coated-with-2-deoxy-d-gloucose-and-doxorubicin-more-sensitize-breast-cancer-cells-to-ionizing-radiation
#10
Jalil Pirayesh Islamian, Milad Hatamian, Negar Abbasi Aval, Mohammad Reza Rashidi, Asghar Mesbahi, Mohammad Mohammadzadeh, Mohammad Asghari Jafarabadi
INTRODUCTION: Nanoparticles are promising as a new approach to enhance chemo- radiotherapy efficiency in breast cancer mainly via targeted therapy. MATERIALS & METHODS: SKBR3 and T47D breast cancer cells were treated with superparamagnetic mesoporous hydroxyapatite nanocomposites (SPmHANs)conjugated with 1 μM doxorubicin and 0.5 mM 2-Deoxy-d-Glucose and irradiated with 1 and 2 Gy gamma rays in vitro. The treatment toxicity and also the apoptosis/necrosis ratio were measured by MTT assay and also ELISA cell death detection PLUS, respectively...
March 25, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28350989/mir-219-cooperates-with-mir-338-in-myelination-and-promotes-myelin-repair-in-the-cns
#11
Haibo Wang, Ana Lis Moyano, Zhangyan Ma, Yaqi Deng, Yifeng Lin, Chuntao Zhao, Liguo Zhang, Minqing Jiang, Xuelian He, Zhixing Ma, Fanghui Lu, Mei Xin, Wenhao Zhou, Sung Ok Yoon, Ernesto R Bongarzone, Q Richard Lu
A lack of sufficient oligodendrocyte myelination contributes to remyelination failure in demyelinating disorders. miRNAs have been implicated in oligodendrogenesis; however, their functions in myelin regeneration remained elusive. Through developmentally regulated targeted mutagenesis, we demonstrate that miR-219 alleles are critical for CNS myelination and remyelination after injury. Further deletion of miR-338 exacerbates the miR-219 mutant hypomyelination phenotype. Conversely, miR-219 overexpression promotes precocious oligodendrocyte maturation and regeneration processes in transgenic mice...
March 27, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28350987/the-super-elongation-complex-drives-neural-stem-cell-fate-commitment
#12
Kun Liu, Dan Shen, Jingwen Shen, Shihong M Gao, Bo Li, Chouin Wong, Weidong Feng, Yan Song
Asymmetric stem cell division establishes an initial difference between a stem cell and its differentiating sibling, critical for maintaining homeostasis and preventing carcinogenesis. Yet the mechanisms that consolidate and lock in such initial fate bias remain obscure. Here, we use Drosophila neuroblasts to demonstrate that the super elongation complex (SEC) acts as an intrinsic amplifier to drive cell fate commitment. SEC is highly expressed in neuroblasts, where it promotes self-renewal by physically associating with Notch transcription activation complex and enhancing HES (hairy and E(spl)) transcription...
March 27, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28350976/neuroendocrine-tumor-of-the-common-bile-duct-case-report
#13
C Raspanti, N Falco, V Silvestri, G Rotolo, S Bonventre, G Gulotta
Neuroendocrine tumors (NET) are a very heterogeneous group of neoplasms; in recent years we have seen an increase in their incidence (3.65 /100.000/year). They can be associated with hereditary endocrine syndromes (MEN, Von Hippel Lindau); they can occur at any age and the incidence is slightly higher in men than women. The aetiology of the neuroendocrine tumors is unclear; in most cases, inflammation of the bile ducts may be the underlying cause and for this reason, the initial patient's evaluation should be focused on the different aspects concerning the oncological one and the possible sequelae of the biliary obstructions that can evolve in biliary sepsis...
November 2016: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28350966/cationic-phosphorus-dendrimer-enhances-photodynamic-activity-of-rose-bengal-against-basal-cell-carcinoma-cell-lines
#14
Monika Dabrzalska, Anna Janaszewska, Maria Zablocka, Serge Mignani, Jean Pierre Majoral, Barbara Klajnert-Maculewicz
In the last couple of decades, photodynamic therapy emerged as a useful tool in the treatment of basal cell carcinoma. However, it still meets limitations due to unfavorable properties of photosensitizers, such as poor solubility or lack of selectivity. Dendrimers - polymers widely studied in biomedical field - may play a role as photosensitizer carriers and improve the efficacy of photodynamic treatment. Here, we describe the evaluation of an electrostatic complex of cationic phosphorus dendrimer and rose bengal in such aspects as singlet oxygen production, cellular uptake and phototoxicity against three basal cell carcinoma cell lines...
March 28, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28350963/gd-dots-with-strong-ligand-water-interaction-for-ultrasensitive-magnetic-resonance-renography
#15
Xiao-Yu Zheng, Kai Zhao, Jinglong Tang, Xin-Yu Wang, Lin-Dong Li, Nai-Xiu Chen, Yan-Jie Wang, Shuo Shi, Xiaodong Zhang, Sivakumar Malaisamy, Ling-Dong Sun, Xiaoying Wang, Chunying Chen, Chun-Hua Yan
Magnetic resonance imaging (MRI) contrast agents (CAs) with both significantly enhanced relaxivity and minimal safety risk are of great importance for sensitive clinical diagnosis, which, however, have rarely been reported. Herein, we present a simple strategy to improve relaxivity by introducing surface ligands with strong interaction to water molecules. As a proof of concept, NaGdF4 nanoparticles (NPs) capped by polyacrylic acid (PAA) show superior relaxivity to those capped by polyethylenimine (PEI) and polyethylene glycol (PEG), which is attributed to the strong hydrogen bond capacity of PAA to water molecules as revealed by theoretical calculation...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28350960/enhanced-stability-of-magnetic-skyrmion-lattice-phase-under-a-tilted-magnetic-field-in-two-dimensional-chiral-magnet
#16
Chao Wang, Haifeng Du, Xuebing Zhao, Chiming Jin, Mingliang Tian, Yuheng Zhang, Renchao Che
Magnetic skyrmion is a topologically stable vortex-like spin texture that offers great promise as information carriers for future spintronic devices. In a two-dimensional chiral magnet, it was generally considered that a tilted magnetic field is harmful to its formation and stability. Here we investigated the angular dependent stability of magnetic skyrmions in FeGe nanosheets by using high-resolution Lorentz transmission electron microscopy (Lorentz TEM). Besides the theoretically predicted destruction of skyrmion lattice state by an oblique magnetic field as temperature close to its magnetic Curie temperature Tc~278 K, we also observed an unexpected reentry-like phenomenon at the moderate temperatures near the border between conical and skyrmion phase,Tt~240 K...
March 28, 2017: Nano Letters
https://www.readbyqxmd.com/read/28350955/long-lived-species-enhance-summertime-attribution-of-north-american-ozone-to-upwind-sources
#17
Yixin Guo, Junfeng Liu, Denise L Mauzerall, Xiaoyuan Li, Larry W Horowitz, Wei Tao, Shu Tao
Ground-level ozone, harmful to most living things, is produced from both domestic and foreign emissions of anthropogenic precursors. Previous estimates of the linkage from distant sources rely on the sensitivity approach (i.e., modeling the change of ozone concentrations that result from modifying precursor emissions) as well as tagging approach (i.e., tracking ozone produced from specific O3 precursors emitted from one region). Here, for the first time, we tag all O3 precursors (i.e., nitrogen oxides, carbon monoxide (CO), volatile organic compounds (VOCs) ) from East Asia and explicitly track their physicochemical evolution without perturbing the non-linear O3 chemistry...
March 28, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28350949/state-of-the-art-in-degenerative-cervical-myelopathy-an-update-on-current-clinical-evidence
#18
Jefferson R Wilson, Lindsay A Tetreault, Jun Kim, Mohammed F Shamji, James S Harrop, Thomas Mroz, Samuel Cho, Michael G Fehlings
Degenerative cervical myelopathy (DCM) is a common cause of spinal cord dysfunction that confronts clinicians on a daily basis. Research performed over the past few decades has provided improved insight into the diagnosis, evaluation, and treatment of this disorder. We aim to provide clinicians with an update regarding the state of the art in DCM, focusing on more recent research pertaining to pathophysiology, natural history, treatment, consideration of the minimally symptomatic patient, surgical outcome prediction, and outcome measurement...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28350939/the-advancing-role-of-neuromodulation-for-the-management-of-chronic-treatment-refractory-pain
#19
Mohammed F Shamji, Cecile De Vos, Ashwini Sharan
Neuropathic pain is a common cause of disability and health care utilization. While judicious pharmacotherapy and management of comorbid psychological distress can provide for improved quality of life, some patients with treatment-refractory disease require more invasive therapies. Spinal cord stimulation can provide for improvement in pain and decrease in medication utilization, with level 1 evidence supporting its use across various pain etiologies including persistent postoperative neuropathic pain, complex regional pain syndrome, chronic inoperable limb ischemia, treatment refractory angina, and painful diabetic neuropathy...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28350899/fundamentals-and-catalytic-innovation-the-statistical-and-data-management-center-of-the-antibacterial-resistance-leadership-group
#20
Jacqueline Huvane, Lauren Komarow, Carol Hill, Thuy Tien T Tran, Carol Pereira, Susan L Rosenkranz, Matt Finnemeyer, Michelle Earley, Hongyu Jeanne Jiang, Rui Wang, Judith Lok, Scott R Evans
The Statistical and Data Management Center (SDMC) provides the Antibacterial Resistance Leadership Group (ARLG) with statistical and data management expertise to advance the ARLG research agenda. The SDMC is active at all stages of a study, including design; data collection and monitoring; data analyses and archival; and publication of study results. The SDMC enhances the scientific integrity of ARLG studies through the development and implementation of innovative and practical statistical methodologies and by educating research colleagues regarding the application of clinical trial fundamentals...
March 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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