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https://www.readbyqxmd.com/read/28743167/preoperative-bevacizumab-and-volumetric-recovery-after-resection-of-colorectal-liver-metastases
#1
Georgios Antonios Margonis, Stefan Buettner, Nikolaos Andreatos, Kazunari Sasaki, Manijeh Zargham Pour, Ammar Deshwar, Jane Wang, Mounes Aliyari Ghasebeh, Christos Damaskos, Neda Rezaee, Timothy M Pawlik, Christopher L Wolfgang, Ihab R Kamel, Matthew J Weiss
BACKGROUND AND OBJECTIVES: While preoperative treatment is frequently administered to CRLM patients, the impact of chemotherapy, with or without bevacizumab, on liver regeneration remains controversial. METHODS: The early and late regeneration indexes were defined as the relative increase in liver volume (RLV) within 2 and 9 months from surgery. Regeneration rates of the preoperative treatment groups were compared. RESULTS: Preoperative chemotherapy details and volumetric data were available for 185 patients; 78 (42...
July 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28743125/surfactant-protein-b-suppresses-lung-cancer-progression-by-inhibiting-secretory-phospholipase-a2-activity-and-arachidonic-acid-production
#2
Sungmin Lee, Daehoon Kim, JiHoon Kang, EunGi Kim, Wanyeon Kim, HyeSook Youn, BuHyun Youn
BACKGROUND/AIMS: Radiotherapy is applied to patients with inoperable cancer types including advanced stage non-small cell lung cancer (NSCLC) and radioresistance functions as a critical obstacle in radiotherapy. This study was aimed to investigate the mechanism of radioresistance regulated by surfactant protein B (SP-B). METHODS: To investigate the role of SP-B in radioresistance, ΔSFTPB A549 cell line was established and SP-B expression was analyzed. In response to ionizing radiation (IR), the change of SP-B expression was analyzed in A549 and NCI-H441 cell lines...
July 25, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28743099/laparoscopic-surgery-for-colon-cancer-with-intestinal-malrotation-in-adults-two-case-reports-and-review-of-literatures-in-japan
#3
Kazuyoshi Nakatani, Katsuji Tokuhara, Tatsuma Sakaguchi, Kazuhiko Yoshioka, Masanori Kon
INTRODUCTION: Intestinal malrotation is a congenital anomaly, and its occurrence in adults is rare. Colon cancer with intestinal malrotation is far more rare. We herein report two cases of colon cancer with intestinal malrotation treated with laparoscopic surgery and reviewed the literatures in Japan. PRESENTATION OF CASES: Case 1 involved a 78-year-old man. Abdominal enhanced computed tomography (CT) showed that the tumor was located in the sigmoid colon. Intraoperatively, the cecum and ascending colon were located along the midline and the small intestine occupied the right side of the abdomen...
July 13, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28743090/nir-and-uv-responsive-degradable-hyaluronic-acid-nanogels-for-cd44-targeted-and-remotely-triggered-intracellular-doxorubicin-delivery
#4
Chunfeng Hang, Yan Zou, Yinan Zhong, Zhiyuan Zhong, Fenghua Meng
Hyaluronic acid (HA) is an endogenous polysaccharide that shows intrinsic targetability to CD44+ cancer cells. Here, we developed NIR and UV-responsive degradable nanogels from hyaluronic acid-g-7-N,N-diethylamino-4-hydroxymethylcoumarin (HA-CM) for CD44 targeted and remotely controlled intracellular doxorubicin (DOX) delivery. Nanometer-sized HA-CM nanogels could readily load DOX, and both NIR and UV irradiation could significantly enhance DOX release from the nanogels, resulting from light-triggered cleavage of urethane bonds that connect CM to HA...
July 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28743088/chitosan-derived-co-spheroids-of-neural-stem-cells-and-mesenchymal-stem-cells-for-neural-regeneration
#5
Hao-Wei Han, Shan-Hui Hsu
Chitosan has been considered as candidate biomaterials for neural applications. The effective treatment of neurodegeneration or injury to the central nervous system (CNS) is still in lack nowadays. Adult neural stem cells (NSCs) represents a promising cell source to treat the CNS diseases but they are limited in number. Here, we developed the core-shell spheroids of NSCs (shell) and mesenchymal stem cells (MSCs, core) by co-culturing cells on the chitosan surface. The NSCs in chitosan derived co-spheroids displayed a higher survival rate than those in NSC homo-spheroids...
July 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28743085/direct-electrodeposition-of-graphene-enhanced-conductive-polymer-on-microelectrode-for-biosensing-application
#6
Ming-Hao Wang, Bo-Wen Ji, Xiao-Wei Gu, Hong-Chang Tian, Xiao-Yang Kang, Bin Yang, Xiao-Lin Wang, Xiang Chen, Cheng-Yu Li, Jing-Quan Liu
Engineering of neural interface with nanomaterials for high spatial resolution neural recording and stimulation is still hindered by materials properties and modification methods. Recently, poly(3,4-ethylene-dioxythiophene) (PEDOT) has been widely used as an electrode-tissue interface material for its good electrochemical property. However, cracks and delamination of PEDOT film under pulse stimulation are found which restrict its long-term applications. This paper develops a flexible electrochemical method about the co-deposition of graphene with PEDOT on microelectrode sites to enhance the long-term stability and improve the electrochemical properties of microelectrode...
July 13, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28743083/hall-effect-biosensors-with-ultraclean-graphene-film-for-improved-sensitivity-of-label-free-dna-detection
#7
Phan Thi Kim Loan, Dongqin Wu, Chen Ye, Xiaoqing Li, Vu Thanh Tra, Qiuping Wei, Li Fu, Aimin Yu, Lain-Jong Li, Cheng-Te Lin
The quality of graphene strongly affects the performance of graphene-based biosensors which are highly demanded for the sensitive and selective detection of biomolecules, such as DNA. This work reported a novel transfer process for preparing a residue-free graphene film using a thin gold supporting layer. A Hall effect device made of this gold-transferred graphene was demonstrated to significantly enhance the sensitivity (≈ 5 times) for hybridization detection, with a linear detection range of 1pM to 100nM for DNA target...
July 19, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28743081/mycobacterium-tuberculosis-ppe44-rv2770c-is-involved-in-response-to-multiple-stresses-and-promotes-the-macrophage-expression-of-il-12-p40-and-il-6-via-the-p38-erk-and-nf-%C3%AE%C2%BAb-signaling-axis
#8
Zhaoxiao Yu, Chenhui Zhang, Mingliang Zhou, Qiming Li, Hui Li, Wei Duan, Xue Li, Yonghong Feng, Jianping Xie
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a formidable threat to global public health. The successful intracellular persistence of M. tuberculosis significantly contributes to the intractability of tuberculosis. Proline-glutamic acid (PE) and proline-proline-glutamic acid (PPE) are mycobacterial exclusive protein families that widely reported to be involved in the bacterial virulence, physiology and interaction with host. Rv2770c (PPE44), a predicted virulence factor, was up-regulated upon the infected guinea pig lungs...
July 22, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28743079/impact-of-lyophilized-lactobacillus-salivarius-dspv-001p-administration-on-growth-performance-microbial-translocation-and-gastrointestinal-microbiota-of-broilers-reared-under-low-ambient-temperature
#9
J E Blajman, C A Olivero, M L Fusari, J A Zimmermann, E Rossler, A P Berisvil, A Romero Scharpen, D M Astesana, L P Soto, M L Signorini, M V Zbrun, L S Frizzo
This study was undertaken with the aim of investigating the effects of dietary supplementation of probiotic strain Lactobacillus salivarius DSPV 001P on growth performance, microbial translocation, and gastrointestinal microbiota of broilers reared under low ambient temperature. Two hundred and forty, one-day-old male Cobb broilers were randomly distributed into two treatment groups, a probiotic group and a control group, with four replicates per treatment and 30 broilers per replicate. The temperature of the broiler house was maintained at 18-22°C during the first three weeks, after which the temperature was at range of 8°C to 12°C...
July 19, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28743073/in-situ-biodegradation-potential-of-1-2-dca-and-vc-at-sites-with-different-hydrogeological-settings
#10
R C M Nobre, M M M Nobre, T M P Campos, D Ogles
This paper investigates the feasibility of applying in-situ Bioremediation (ISB) to three sites contaminated with vinyl chloride and/or chlorinated alkanes such as 1,2-DCA and 1,1,2-TCA, presenting distinct hydrogeological settings and history of contaminant loading. Biotransformation of these compounds is well established in laboratory studies and pure cultures. Due to confidential aspects, however, few field data are available to support real case studies to the predictability of their fate and lifetime in soil and groundwater...
July 15, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28743061/circulating-ctrp9-levels-are-increased-in-patients-with-newly-diagnosed-type-2-diabetes-and-correlated-with-insulin-resistance
#11
Yanjun Jia, Xiaohe Luo, Ying Ji, Jingwen Xie, Han Jiang, Mao Fu, Xiaoqiang Li
AIMS: C1q/TNF-related protein-9 (CTRP9) is a novel adipokine that has been shown to promote lipid metabolism, enhance insulin sensitivity and protect against cardiovascular disease. However, previous studies in humans have produced controversial results regarding the association between CTRP9 and insulin resistance. The objective of this study was to evaluate the relationships between CTRP9 and insulin resistance in Chinese population. METHODS: Subjects with normal glucose tolerance (NGT, n=108), impaired glucose tolerance (IGT, n=92), and newly diagnosed type 2 diabetes mellitus (nT2DM, n=106) were recruited to determining the circulating CTRP9 and adiponectin levels by enzyme linked immunosorbent assay...
July 8, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28743051/enhancing-women-s-confidence-for-physiologic-birth-maternity-care-providers-perspectives
#12
Melissa A Saftner, Carrie Neerland, Melissa D Avery
OBJECTIVE: The aim of this research study was to explore MCP's beliefs and attitudes about physiologic birth and to identify components of antenatal care that providers believe may impact a woman's confidence for physiologic labor and birth. METHODS: This qualitative descriptive study included maternity care providers (N=31) in the Midwestern United States. Providers participated in semi-structured interviews to describe their beliefs about physiologic birth, their role in providing information to women and specific care practices to promote women's confidence for physiologic birth...
July 18, 2017: Midwifery
https://www.readbyqxmd.com/read/28743044/electrophysiological-and-gene-expression-characterization-of-the-ontogeny-of-nestin-expressing-cells-in-the-adult-mouse-midbrain
#13
Anupama Dey, Parisa Farzanehfar, Elena V Gazina, Tim D Aumann
The birth of new neurons, or neurogenesis, in the adult midbrain is important for progressing dopamine cell-replacement therapies for Parkinson's disease. Most studies suggest newborn cells remain undifferentiated or differentiate into glia within the adult midbrain. However, some studies suggest nestin+neural precursor cells (NPCs) have a propensity to generate new neurons here. We sought to confirm this by administering tamoxifen to adult NesCreER(T2)/R26eYFP transgenic mice, which permanently labelled adult nestin-expressing cells and their progeny with enhanced yellow fluorescent protein (eYFP)...
July 4, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28743039/exogenous-application-of-poly-%C3%AE-glutamic-acid-enhances-stress-defense-in-brassica-napus-l-seedlings-by-inducing-cross-talks-between-ca-2-h2o2-brassinolide-and-jasmonic-acid-in-leaves
#14
Zongqi Xu, Peng Lei, Xiao Pang, Huashan Li, Xiaohai Feng, Hong Xu
Poly-γ-glutamic acid (γ-PGA) is a microbe-secreted isopeptide shown to promote growth and enhance crop stress tolerance. However, its downstream signaling pathways are unknown. Here, we studied γ-PGA-induced tolerance to salt and cold stresses. Pretreatment with γ-PGA contributed to enhance stress tolerance of canola seedlings by promoting proline accumulation and total antioxidant capacity (T-AOC) improvement. Further, Ca(2+), H2O2, brassinolide, and jasmonic acid were found to be involved in the γ-PGA-induced process...
July 17, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28743028/enhanced-photo-electrochemical-response-of-reduced-graphene-oxide-and-c3n4-nanosheets-for-rutin-detection
#15
Jin Wang, Beibei Yang, Shumin Li, Bo Yan, Hui Xu, Ke Zhang, Yuting Shi, Chunyang Zhai, Yukou Du
Herein, a sensitive photo-electrochemical sensor based on C3N4 and reduced graphene oxide nanosheets modified glassy carbon electrode (C3N4-RGO/GCE) has been fabricated for the detection of rutin under UV light illumination. In C3N4-RGO catalyst, RGO not only works as a template but also promotes electron transfer, meanwhile, C3N4 acts as a photocatalyst. Benefiting from the superior electron transfer capacity and efficient UV light effect of the C3N4-RGO catalyst, we get a photo-electrochemical sensor for the rutin detecting with a low detection limit of 1...
July 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28742995/icaritin-induces-mc3t3-e1-subclone14-cell-differentiation-through-estrogen-receptor-mediated-erk1-2-and-p38-signaling-activation
#16
Zhidi Wu, Ling Ou, Chaopeng Wang, Li Yang, Panpan Wang, Hengrui Liu, Yingquan Xiong, Kehuan Sun, Ronghua Zhang, Xiaofeng Zhu
Icaritin (ICT), a hydrolytic product of icariin from the genus Epimedium, has many indicated pharmacological and biological activities. Several studies have shown that ICT has potential osteoprotective effects, including stimulation of osteoblast differentiation and inhibition of osteoclast differentiation. However, the molecular mechanism for this anabolic action of ICT remains largely unknown. Here, we found that ICT could enhance MC3T3-E1 subclone 14 preosteoblastic cell differentiation associated with increased mRNA levels and protein expression of the differentiation markers alkaline phosphatase (ALP), type 1 collagen (COL1), osteocalcin (OC), osteoponin (OPN) and runt-related transcription factor 2 (RUNX2), and improved mineralization, confirmed by bone nodule formation and collagen synthesis...
July 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28742985/gabab-receptors-suppress-burst-firing-in-reticular-thalamic-neurons
#17
Stuart M Cain, Esperanza Garcia, Zeina Waheed, Karen L Jones, Trevor J Bushell, Terrance P Snutch
Burst-firing in thalamic neurons is known to play a key role in mediating thalamocortical (TC) oscillations that are associated with non-REM sleep and some types of epileptic seizure. Within the TC system the primary output of GABAergic neurons in the reticular thalamic nucleus (RTN) is thought to induce the de-inactivation of T-type calcium channels in thalamic relay (TR) neurons, promoting burst-firing drive to the cortex and the propagation of TC network activity. However, RTN neurons also project back onto other neurons within the RTN...
July 25, 2017: Channels
https://www.readbyqxmd.com/read/28742973/role-of-vitamin-a-oral-supplementation-on-oxidative-stress-and-inflammatory-response-in-the-liver-of-trained-rats
#18
Lyvia Lintzmaier Petiz, Alice Kunzler, Rafael Calixto Bortolin, Juciano Gasparotto, Cristiane Matté, José Claudio Fonseca Moreira, Daniel Pens Gelain
The use of dietary supplements to enhance the benefit of exercise training is a common practice. The liver is the organ where all substances are metabolized, and certain supplements have been associated with liver injury. Vitamin A (VA), a liposoluble vitamin stored in the liver, is commonly used as an antioxidant supplement. Here, we evaluated the effect of chronic VA supplementation on oxidative damage and stress parameters in trained rats. Animals were divided into the following groups: sedentary (SE), sedentary/VA (SE+VA), exercise training (ET), and exercise training/VA (ET+VA)...
July 25, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28742971/evidence-for-quinone-redox-chemistry-mediating-daytime-and-nighttime-no2-to-hono-conversion-on-soil-surfaces
#19
Nicole K Scharko, Erin T Martin, Yaroslav B Losovyj, Dennis G Peters, Jonathan D Raff
Humic acid (HA) is thought to promote NO2 conversion to nitrous acid (HONO) on soil surfaces during the day. However, it has proven difficult to identify the reactive sites in natural HA substrates. The mechanism of NO2 reduction on soil surrogates comprised of HA and clay minerals was studied by use of a coated-wall flow reactor coupled to cavity-enhanced spectroscopy. Conversion of NO2 to HONO in the dark was found to be significant and correlated to the abundance of C‒O moieties in HA determined from X-ray photoelectron spectra of the C1s region...
July 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28742970/interaction-behaviors-of-fibrinopeptide-a-and-graphene-with-different-functional-groups-a-molecular-dynamics-simulation-approach
#20
Menghao Wang, Qun Wang, Xiong Lu, Ke Feng Wang, Liming Fang, Fuzeng Ren, Guoming Lu, Hongping Zhang
Graphene as a 2-dimentional material has been widely used in the field of biomedical applications. In this study, molecular dynamics simulations are carried out on the fibrinopeptide-A and graphene surfaces with N and O modifications. A new set of parameters for CHARMM force field are developed to describe the behaviors of the surfaces. Our results indicate that the existence of most oxygen and nitrogen groups may enhance the interaction between the surfaces and the peptide, whereas the substitutional nitrogen on the graphene surface does not make a big difference...
July 25, 2017: Journal of Physical Chemistry. B
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