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https://www.readbyqxmd.com/read/29683248/computer-guided-chin-harvest-a-novel-approach-for-autogenous-block-harvest-from-the-mandibular-symphesis
#1
Ahmed H Osman, Mohammed Atef
BACKGROUND: The introduction of CAD/CAM technology allowed clinicians to carry out complex procedures with a high level of precision and reproducibility and minimize the risk of injury during the procedure. PURPOSE: The aim of the present study is to evaluate the efficacy of the CAD/CAM surgical guide during chin harvesting procedures in reducing the risk of neurosensory damage and patient morbidity compared with the standard technique. MATERIALS AND METHODS: About 20 cases of autogenous block chin harvest were randomly into two groups...
April 23, 2018: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29681816/fluorescent-light-guided-cystoscopy-with-5-ala-aids-in-accurate-surgical-margin-detection-for-turbo-a-case-report
#2
Daiji Takamoto, Takashi Kawahara, Shinji Ohtake, Taku Mochizuki, Shinnosuke Kuroda, Noboru Nakaigawa, Koji Izumi, Yasuhide Miyoshi, Kazuhide Makiyama, Masahiro Yao, Tomoe Sawazumi, Yoshiaki Inayama, Junichi Ohta, Hiroji Uemura
Recent studies have revealed that transurethral resection in one piece (TURBO) has several benefits over standard transurethral resection of bladder tumor (TUR-Bt), including a higher rate of containing the bladder muscle tissue and single-block resection. Five-aminolevulinic acid (5-ALA) was approved for the detection of bladder tumor treated with TUR-Bt. A 71-year-old male patient who received right nephroureterectomy developed bladder tumor recurrence on routine cystoscopy follow-up. We planned TURBO using fluorescent light-guided cystoscopy with 5-ALA...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29681422/spectral-analysis-of-ultrasound-radiofrequency-backscatter-for-the-detection-of-intercostal-blood-vessels
#3
Jon D Klingensmith, Asher Haggard, Russell J Fedewa, Beidi Qiang, Kenneth Cummings, Sean DeGrande, D Geoffrey Vince, Hesham Elsharkawy
Spectral analysis of ultrasound radiofrequency backscatter has the potential to identify intercostal blood vessels during ultrasound-guided placement of paravertebral nerve blocks and intercostal nerve blocks. Autoregressive models were used for spectral estimation, and bandwidth, autoregressive order and region-of-interest size were evaluated. Eight spectral parameters were calculated and used to create random forests. An autoregressive order of 10, bandwidth of 6 dB and region-of-interest size of 1.0 mm resulted in the minimum out-of-bag error...
April 19, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29679696/effect-of-neuromonitor-guided-titrated-care-on-brain-tissue-hypoxia-after-opioid-overdose-cardiac-arrest
#4
Jonathan Elmer, Katharyn L Flickinger, Maighdlin W Anderson, Allison Koller, Matthew Sundermann, Cameron Dezfulian, David O Okonkwo, Lori A Shutter, David Salcido, Clifton W Callaway, James J Menegazzi
INTRODUCTION: Brain tissue hypoxia may contribute to preventable secondary brain injury after cardiac arrest. We developed a porcine model of opioid overdose cardiac arrest and post-arrest care including invasive, multimodal neurological monitoring of regional brain physiology. We hypothesized brain tissue hypoxia is common with usual post-arrest care and can be prevented by modifying mean arterial pressure (MAP) and arterial oxygen concentration (PaO2 ). METHODS: We induced opioid overdose and cardiac arrest in sixteen swine, attempted resuscitation after 9 minutes of apnea, and randomized resuscitated animals to three alternating 6-hour blocks of standard or titrated care...
April 18, 2018: Resuscitation
https://www.readbyqxmd.com/read/29677030/a-cadaveric-study-of-ultrasound-guided-maxillary-nerve-block-via-the-pterygopalatine-fossa-a-novel-technique-using-the-lateral-pterygoid-plate-approach
#5
Wirinaree Kampitak, Tanvaa Tansatit, Yasuyuki Shibata
BACKGROUND AND OBJECTIVES: This study aimed to describe and assess the accuracy and feasibility of a novel technique for ultrasound-guided maxillary nerve block using the lateral pterygoid plate (LPP) approach via the pterygopalatine fossa (PPF) in a soft cadaveric model. METHODS: Ten soft cadavers were studied. The curved array ultrasound transducer probe was applied over 1 side of the face of the cadavers in the open-mouth posture. It was placed transversely below the zygomatic arch for identifying the border of the maxillary tuberosity and the LPP...
April 19, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29675966/unilateral-cervical-plexus-block-for-prosthetic-laryngoplasty-in-the-standing-horse
#6
L Campoy, T Morris, N Ducharme, R Gleed, M Martin-Flores
BACKGROUND: Locoregional anaesthetic techniques can facilitate certain surgeries being performed under standing procedural sedation. The second and third spinal cervical nerves (C2, C3) are part of the cervical plexus and provide sensory innervation to the peri-laryngeal structures in people; block of these nerves might permit laryngeal lateralisation surgery in horses. OBJECTIVES: To describe the anatomical basis for an ultrasound-guided cervical plexus block in horses...
April 20, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29672368/pectoral-i-block-does-not-improve-postoperative-analgesia-after-breast-cancer-surgery-a-randomized-double-blind-dual-centered-controlled-trial
#7
Jérôme Cros, Patrick Sengès, Suzan Kaprelian, Julie Desroches, Caroline Gagnon, Anaïs Labrunie, Benoît Marin, Sabrina Crépin, Nathalie Nathan, Pierre Beaulieu
BACKGROUND AND OBJECTIVES: General anesthesia for breast surgery may be supplemented by using a regional anesthetic technique. We evaluated the efficacy of the first pectoral nerve block (Pecs I) in treating postoperative pain after breast cancer surgery. METHODS: A randomized, double-blind, dual-centered, placebo-controlled trial was performed. One hundred twenty-eight patients scheduled for unilateral breast cancer surgery were recruited. A multimodal analgesic regimen and surgeon-administered local anesthetic infiltration were used for all patients...
April 18, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29672021/foldamer-tertiary-structure-through-sequence-guided-protein-backbone-alteration
#8
Kelly L George, W Seth Horne
The prospect of recreating the complex structural hierarchy of protein folding in synthetic oligomers with backbones that are artificial in covalent structure ("foldamers") has long fascinated chemists. Foldamers offer complex functions from biostable scaffolds and have found widespread applications in fields from biomedical to materials science. Most precedent has focused on isolated secondary structures or their assemblies. In considering the goal of complex protein-like tertiary folding patterns, a key barrier became apparent...
April 19, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29671320/site-directed-synthesis-of-cobalt-oxide-clusters-in-a-metal-organic-framework
#9
Aaron W Peters, Kenichi Otake, Ana E Platero-Prats, Zhanyong Li, Matthew R DeStefano, Karena W Chapman, Omar K Farha, Joseph T Hupp
Direct control over structure and location of catalytic species deposited on amorphous supports represents a formidable challenge in heterogeneous catalysis. In contrast, a structurally well-defined, crystalline metal-organic framework (MOF) can be rationally designed using postsynthetic techniques to allow for desired structural or locational changes of deposited metal ions. Herein, naphthalene dicarboxylate linkers are incorporated in the MOF, NU-1000, to block the small cavities where few-atom clusters of cobalt oxide preferentially grow, inducing catalyst deposition toward hitherto ill-favored grafting sites orientated toward NU-1000s mesoporous channels...
April 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29670941/organization-of-feed-forward-loop-motifs-reveals-architectural-principles-in-natural-and-engineered-networks
#10
Thomas E Gorochowski, Claire S Grierson, Mario di Bernardo
Network motifs are significantly overrepresented subgraphs that have been proposed as building blocks for natural and engineered networks. Detailed functional analysis has been performed for many types of motif in isolation, but less is known about how motifs work together to perform complex tasks. To address this issue, we measure the aggregation of network motifs via methods that extract precisely how these structures are connected. Applying this approach to a broad spectrum of networked systems and focusing on the widespread feed-forward loop motif, we uncover striking differences in motif organization...
March 2018: Science Advances
https://www.readbyqxmd.com/read/29670771/erector-spinae-plane-block-for-different-laparoscopic-abdominal-surgeries-case-series
#11
Serkan Tulgar, Onur Selvi, Mahmut Sertan Kapakli
The ultrasound guided erector spinae plane (ESP) block is a recent block described for various surgeries for postoperative analgesia. ESP block has effect on both visceral and somatic pain; therefore, its use in laparoscopic cholecystectomy and other abdominal surgeries can be advantageous. We describe successful ESP block application in three different cases for postoperative pain. Two patient were operated on using endoscopic retrograde cholangiopancreatography and laparoscopic cholecystectomy and one patient was operated on using laparoscopic cholecystectomy together with the inguinal hernia operation...
2018: Case Reports in Anesthesiology
https://www.readbyqxmd.com/read/29670699/cell-based-kinetic-target-guided-synthesis-of-an-enzyme-inhibitor
#12
Henrik Antti, Magnus Sellstedt
Finding a new drug candidate for a selected target is an expensive and time-consuming process. Target guided-synthesis, or in situ click chemistry, is a concept where the drug target is used to template the formation of its own inhibitors from reactive building blocks. This could simplify the identification of drug candidates. However, with the exception of one example of an RNA-target, target-guided synthesis has always employed purified targets. This limits the number of targets that can be screened by the method...
April 12, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29670144/chromobacterium-spp-mediate-their-anti-plasmodium-activity-through-secretion-of-the-histone-deacetylase-inhibitor-romidepsin
#13
Raúl G Saraiva, Callie R Huitt-Roehl, Abhai Tripathi, Yi-Qiang Cheng, Jürgen Bosch, Craig A Townsend, George Dimopoulos
The Chromobacterium sp. Panama bacterium has in vivo and in vitro anti-Plasmodium properties. To assess the nature of the Chromobacterium-produced anti-Plasmodium factors, chemical partition was conducted by bioassay-guided fractionation where different fractions were assayed for activity against asexual stages of P. falciparum. The isolated compounds were further partitioned by reversed-phase FPLC followed by size-exclusion chromatography; high resolution UPLC and ESI/MS data were then collected and revealed that the most active fraction contained a cyclic depsipeptide, which was identified as romidepsin...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669835/characterization-of-three-novel-linear-neutralizing-b-cell-epitopes-in-the-capsid-protein-of-swine-hepatitis-e-virus
#14
Yiyang Chen, Baoyuan Liu, Yani Sun, Huixia Li, Taofeng Du, Yuchen Nan, Julian A Hiscox, En-Min Zhou, Qin Zhao
Hepatitis E virus (HEV) causes liver disease in humans and is thought to be a zoonotic infection with domestic animals being a reservoir including swine and rabbits. One of the proteins encoded by the virus is the capsid protein. This is likely the major immune-dominant protein and a target for vaccination. Four monoclonal antibodies (MAbs); three novel; 1E4, 2C7, 2G9, and one previously characterized (1B5), were evaluated for binding to the capsid protein from genotype 4 (swine) hepatitis E virus (HEV). The results indicated that 625 DFCP628 , 458 PSRPF462 , and 407 EPTV410 peptides on the capsid protein comprised minimal amino acid sequence motifs recognized by 1E4, 2C7, and 2G9, respectively...
April 18, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29669823/recurrent-patterns-of-protein-expression-signatures-in-pediatric-acute-lymphoblastic-leukemia-recognition-and-therapeutic-guidance
#15
Fieke W Hoff, Chenyue W Hu, Yihua Qiu, Andrew Ligeralde, Suk-Young Yoo, Eveline Sjm De Bont, Amina A Qutub, Terzah M Horton, Steven M Kornblau
Pediatric acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, and the second leading cause of pediatric cancer death in developed countries. While the cure rate for newly-diagnosed ALL is excellent, the genetic heterogeneity and chemoresistance of leukemia cells at relapse makes individualized curative treatment plans difficult. We hypothesize that genetic events would coalesce into a finite number of protein signatures that could guide the design of individualized therapy. Custom Reverse Phase Protein Arrays were produced from pediatric ALL (n=73) and normal CD34+ (n=10) samples with 194 validated antibodies...
April 18, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29668608/optimal-dose-of-perineural-dexmedetomidine-for-interscalene-brachial-plexus-block-to-control-postoperative-pain-in-patients-undergoing-arthroscopic-shoulder-surgery-a-prospective-double-blind-randomized-controlled-study
#16
Hong Soo Jung, Kwon Hui Seo, Jae Hyuk Kang, Jin-Young Jeong, Yong-Shin Kim, Na-Re Han
BACKGROUND: Adjuvant perineural dexmedetomidine can be used to prolong the analgesic effect of interscalene brachial plexus block (ISB). We investigated the optimal dose of dexmedetomidine in ISB for postoperative analgesia in patients undergoing arthroscopic shoulder surgery. METHODS: One hundred patients scheduled for elective shoulder arthroscopic surgery were enrolled in this randomized, double-blind study. Ultrasound-guided ISB was performed before general anesthesia using 22 mL of ropivacaine 0...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29668467/the-effect-of-rectus-sheath-block-as-a-supplement-of-general-anesthesia-on-postoperative-analgesia-in-adult-patient-undergoing-umbilical-hernia-repair
#17
Andrijan Kartalov, Nikola Jankulovski, Biljana Kuzmanovska, Milka Zdravkovska, Mirjana Shosholcheva, Marija Tolevska, Filip Naumovski, Marija Srceva, Aleksandra Panovska Petrusheva, Rexhep Selmani, Atanas Sivevski
BACKGROUND: Ultrasound guided rectus sheath block can block the ventral rami of the 7th to 12th thoracolumbar nerves by injection of local anesthetic into the space between the rectus muscle and posterior rectus sheath. The aim of this randomized double-blind study was to evaluate the analgesic effect of the bilateral ultrasound guided rectus sheath block as supplement of general anesthesia on patents undergoing elective umbilical hernia repair. METHODS: After the hospital ethics committee approval, 60 (ASA I-II) adult patients scheduled for umbilical hernia repair were included in this study...
December 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/29667927/biophysics-of-object-segmentation-in-a-collision-detecting-neuron
#18
Richard Burkett Dewell, Fabrizio Gabbiani
Collision avoidance is critical for survival, including in humans, and many species possess visual neurons exquisitely sensitive to objects approaching on a collision course. Here, we demonstrate that a collision-detecting neuron can detect the spatial coherence of a simulated impending object, thereby carrying out a computation akin to object segmentation critical for proper escape behavior. At the cellular level, object segmentation relies on a precise selection of the spatiotemporal pattern of synaptic inputs by dendritic membrane potential-activated channels...
April 18, 2018: ELife
https://www.readbyqxmd.com/read/29666115/genetics-of-diffuse-large-b-cell-lymphoma
#19
Laura Pasqualucci, Riccardo Dalla-Favera
Diffuse large B cell lymphoma (DLBCL), the most frequent subtype of lymphoid malignancy, remains a significant clinical challenge, as approximately 30% of patients are not cured. Over the past decade, remarkable progress has been made in the understanding of the pathogenesis of this disease, spurred by the implementation of powerful genomic technologies that enabled the definition of its genetic and epigenetic landscape. These studies have uncovered a multitude of genomic alterations that contribute to the initiation and maintenance of the tumor clone by disrupting biological functions known to be critical for the normal biology of its cells of origin, germinal center B cells...
April 17, 2018: Blood
https://www.readbyqxmd.com/read/29664158/spread-of-injectate-around-hip-articular-sensory-branches-of-the-femoral-nerve-in-cadavers
#20
N D Nielsen, M Greher, B Moriggl, R Hoermann, T D Nielsen, J Børglum, T F Bendtsen
BACKGROUND: Anatomical knowledge dictates that regional anaesthesia after total hip arthroplasty requires blockade of the hip articular branches of the femoral and obturator nerves. A direct femoral nerve block increases the risk of fall and impedes mobilisation. We propose a selective nerve block of the hip articular branches of the femoral nerve by an ultrasound-guided injection in the plane between the iliopsoas muscle and the iliofemoral ligament (the iliopsoas plane). The aim of this study was to assess whether dye injected in the iliopsoas plane spreads to all hip articular branches of the femoral nerve...
April 17, 2018: Acta Anaesthesiologica Scandinavica
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