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https://www.readbyqxmd.com/read/28817802/molecular-memory-of-morphologies-by-septins-during-neuron-generation-allows-early-polarity-inheritance
#1
Leila Boubakar, Julien Falk, Hugo Ducuing, Karine Thoinet, Florie Reynaud, Edmund Derrington, Valérie Castellani
Transmission of polarity established early during cell lineage history is emerging as a key process guiding cell differentiation. Highly polarized neurons provide a fascinating model to study inheritance of polarity over cell generations and across morphological transitions. Neural crest cells (NCCs) migrate to the dorsal root ganglia to generate neurons directly or after cell divisions in situ. Using live imaging of vertebrate embryo slices, we found that bipolar NCC progenitors lose their polarity, retracting their processes to round for division, but generate neurons with bipolar morphology by emitting processes from the same locations as the progenitor...
August 16, 2017: Neuron
https://www.readbyqxmd.com/read/28814096/ankle-block-vs-single-shot-popliteal-fossa-block-as-primary-anesthesia-for-forefoot-operative-procedures-prospective-randomized-comparison
#2
Oliver N Schipper, Kenneth J Hunt, Robert B Anderson, W Hodges Davis, Carroll P Jones, Bruce E Cohen
BACKGROUND: Postoperative pain is often difficult to control with oral medications, requiring large doses of opioid analgesia. Regional anesthesia may be used for primary anesthesia, reducing the need for general anesthetic and postoperative pain medication requirements in the immediate postoperative period. The purpose of this study was to compare the analgesic effects of an ankle block (AB) to a single-shot popliteal fossa block (PFB) for patients undergoing orthopedic forefoot procedures...
August 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28809993/adalimumab-in-chronic-plaque-psoriasis-a-clinical-guide
#3
Jashin J Wu, W C Valdecantos
<p>Psoriasis is a common, inflammatory disease that manifests itself as lesions on the skin, which greatly impacts the physical and psychological wellbeing of those affected. The current goal of treatment in psoriasis is to improve the signs and symptoms of disease, whilst minimizing the burden of disease on patient health-related quality of life. Psoriasis can also be associated with other comorbidities such as joint disease, cardiovascular disease, and depression, which can add to the complexity of treatment...
August 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28808685/structure-of-a-1-5-mda-adhesin-that-binds-its-antarctic-bacterium-to-diatoms-and-ice
#4
Shuaiqi Guo, Corey A Stevens, Tyler D R Vance, Luuk L C Olijve, Laurie A Graham, Robert L Campbell, Saeed R Yazdi, Carlos Escobedo, Maya Bar-Dolev, Victor Yashunsky, Ido Braslavsky, David N Langelaan, Steven P Smith, John S Allingham, Ilja K Voets, Peter L Davies
Bacterial adhesins are modular cell-surface proteins that mediate adherence to other cells, surfaces, and ligands. The Antarctic bacterium Marinomonas primoryensis uses a 1.5-MDa adhesin comprising over 130 domains to position it on ice at the top of the water column for better access to oxygen and nutrients. We have reconstructed this 0.6-μm-long adhesin using a "dissect and build" structural biology approach and have established complementary roles for its five distinct regions. Domains in region I (RI) tether the adhesin to the type I secretion machinery in the periplasm of the bacterium and pass it through the outer membrane...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28803601/ultrasound-guided-transversus-abdominis-plane-block-improves-postoperative-analgesia-and-early-recovery-in-patients-undergoing-retroperitoneoscopic-urologic-surgeries-a-randomized-controlled-double-blinded-trial
#5
Ge Qu, Xu-Lei Cui, Hong-Ju Liu, Zhi-Gang Ji, Yu-Guang Huang
Objective To evaluate the effects of ultrasound-guided transversus abdominis plane (TAP) block on postoperative analgesia and early recovery in patients undergoing retroperitoneoscopic urologic surgeries. Methods This was a randomized, controlled, double-blinded trial. Eligible patients scheduled for retroperitoneoscopic urologic surgeries were randomly assigned to two groups. Group TAP received ultrasound-guided TAP block with 0.5% ropivacaine 20 ml at 30 minutes before surgery, and Group C received TAP sham block with normal saline...
September 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28802593/evaluation-of-ultrasound-guided-posterior-quadratus-lumborum-block-for-postoperative-analgesia-after-laparoscopic-gynecologic-surgery
#6
Junichi Ishio, Nobuyasu Komasawa, Haruki Kido, Toshiaki Minami
STUDY OBJECTIVE: This study aimed to determine the efficacy of ultrasound-guided posterior quadratus lumborum block (QLB) in treating postoperative pain following laparoscopic gynecologic surgery. DESIGN: Prospective randomized controlled study. PATIENTS: Seventy adult patients scheduled for elective laparoscopic gynaecological surgery under general anesthesia. INTERVENTION: This randomized controlled study involved two groups of adult females who were scheduled to undergo laparoscopic gynecologic surgery under general anesthesia...
September 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28798691/fentanyl-promotes-breast-cancer-cell-stemness-and-epithelial-mesenchymal-transition-by-upregulating-%C3%AE-1-6-fucosylation-via-wnt-%C3%AE-catenin-signaling-pathway
#7
Hong-Fang Yang, Ming Yu, Hui-Dan Jin, Jia-Qi Yao, Zhi-Li Lu, Iddrisu B Yabasin, Qiu Yan, Qing-Ping Wen
Cancer pain is a common and severe complication of human breast cancer, and relieving pain is fundamental strategy in the treatment. Fentanyl, as an opioid analgesic, is widely used in breast cancer patients. However, little is known about its effects on stemness and epithelial-mesenchymal transition (EMT) of breast cancer cells. Aberrant protein glycosylation is involved in cancer malignancy. The α1, 6-fucosylation is an important type of glycosylation, and the elevated α1, 6-fucosylation catalyzed by fucosyltransferase VIII (FUT8) is found in many tumors...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28797676/electrogram-signature-of-specific-activation-patterns-analysis-of-atrial-tachycardias-at-high-density-endocardial-mapping
#8
Antonio Frontera, Masateru Takigawa, Ruairidh Martin, Nathaniel Thompson, Ghassen Cheniti, Gregoire Massouille, Josselin Duchateau, JeanYves Wielandts, Elvis Teijera, Takeshi Kitamura, Michael Wolf, Nora Al-Jefairi, Konstantinos Vlachos, Seigo Yamashita, Sana Amraoui, Arnaud Denis, Meleze Hocini, Hubert Cochet, Frederic Sacher, Pierre Jaïs, Michel Haïssaguerre, Nicolas Derval
BACKGROUND: The significance of fractionated electrograms (EGMs) is object of debate with multiple mechanisms described. OBJECTIVE: Using Rhythmia™, a high-density mapping system, we sought to investigate the relationship between specific electrophysiological phenomena and EGM characteristics at those sites. METHODS: 25 consecutive patients underwent High Density (HD) atrial mapping during Atrial Tachycardias (ATs). Bipolar EGMs were recorded with a 64-electrode basket catheter...
August 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28797499/dorsal-scapular-and-long-thoracic-nerves-during-ultrasound-guided-interscalene-brachial-plexus-block
#9
Hyungtae Kim
No abstract text is available yet for this article.
March 2017: Asian J Anesthesiol
https://www.readbyqxmd.com/read/28796131/beyond-ultrasound-guidance-for-regional-anesthesiology
#10
De Q Tran, André P Boezaart, Joseph M Neal
Despite its popularity, ultrasound (US)-guided regional anesthesiology is associated with significant limitations. The latter can be attributed to either the US machine (ie, decreased ability to insonate deep neural structures, as well as the thoracic spine) or the operator. Shortcomings associated with the operator can be explained by errors in perception (ie, ambiguous criteria for needle/catheter tip-to-nerve proximity and subparaneural local anesthetic injection) or interpretation. Perhaps the greatest confusion afflicting US-guided regional anesthesiology originates from an intellectual misconception pertaining to its application...
September 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28795197/ultrasound-guided-interscalene-brachial-plexus-block-in-a%C3%A2-child-with-acute-upper-respiratory-infection-a%C3%A2-case-report
#11
T Ergönenç, H Can, S Gökhan Beyaz
The brachial plexus is commonly blocked at the interscalene level for shoulder and proximal humeral surgery. There are only a few publications about the interscalene technique in pediatric patients for a peripheral nerve block. Ultrasound-guided peripheral nerve block has become increasingly more popular for pediatric patients because of high success rates and safety concerns. We used ultrasound-guided interscalene brachial plexus block in an 18-month-old child with an acute upper respiratory infection who had a supracondylar fracture of the humerus...
August 9, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28794531/a-randomised-comparative-evaluation-of-supraclavicular-and-infraclavicular-approaches-to-brachial-plexus-block-for-upper-limb-surgeries-using-both-ultrasound-and-nerve-stimulator
#12
Ranganathan Jothi Abhinaya, Rajagopalan Venkatraman, Palanisamy Matheswaran, Govindarajan Sivarajan
BACKGROUND AND AIMS: The supraclavicular and infraclavicular brachial plexus blocks have a similar distribution of anaesthesia, and both can be used effectively for surgeries of the upper limb. This study aimed to compare the supraclavicular and infraclavicular approaches of brachial plexus blocks, guided by ultrasound and neurostimulation. METHODS: Sixty adult patients scheduled for elective upper limb surgery of the elbow and/or below were randomly divided into two groups: infraclavicular Group (I) and supraclavicular Group (S)...
July 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28792893/large-stroke-high-fidelity-pzn-pt-single-crystal-stake-actuator
#13
Yu Huang, Yue Xue Xia, Dian Hua Lin, Kui Yao, Leong Chew Lim
A new piezoelectric actuator design, called "Stake" actuator, is proposed and demonstrated in this work. As an example, the stake actuator is made of four d32-mode PZN-5.5%PT single crystals, each of 25mmL × 8mmW × 0.4mmT in dimensions, bonded with the aid of polycarbonate (PC) edge guide-cum-stiffeners into a square-pipe configuration for improved bending and twisting strengths and capped with top and bottom pedestals made of 1.5 mm thick anodized aluminium. The resultant stake actuator measured 9 mm × 9 mm × 28 mm...
August 3, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28791974/experience-with-the-bonanno-catheter-in-the-management-of-ohss-from-ivf-et-cycles
#14
J E Okohue, V K Oriji, J I Ikimalo
OBJECTIVE: To document our experience with the use of the Bonanno catheter as a closed abdominal drain for OHSS Methods: A retrospective study of all IVF embryo transfer (ET) treatment cycles carried out between May 2006 and April 2009 at a dedicated IVF centre. Case notes of patients with OHSS were retrieved and the outcome of the continuous closed abdominal drain with Bonanno catheter documented. RESULT: Within the period under review, 234 patients had controlled ovarian stimulation with ultrasound guided egg retrieval...
July 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28791643/cell-cycle-synchronization-of-hela-cells-to-assay-egfr-pathway-activation
#15
Ping Wee, Zhixiang Wang
Progression through the cell cycle causes changes in the cell's signaling pathways that can alter EGFR signal transduction. Here, we describe drug-derived protocols to synchronize HeLa cells in various phases of the cell cycle, including G1 phase, S phase, G2 phase, and mitosis, specifically in the mitotic stages of prometaphase, metaphase, and anaphase/telophase. The synchronization procedures are designed to allow synchronized cells to be treated for EGF and collected for the purpose of Western blotting for EGFR signal transduction components...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28791598/opioid-medications-in-the-management-of-chronic-abdominal-pain
#16
REVIEW
Dajie Wang
PURPOSE OF REVIEW: Chronic abdominal pain is a complex medical condition. The causes of chronic abdominal pain are extremely diverse ranging from chronic pancreatitis, Crohn's disease, to chronic pain with no clear etiology. Treatment of chronic abdominal pain remains a challenge in our clinical practice. While current interventions with celiac plexus blocks and pain medications provide some relief for these patients, but these treatments are typically less efficacious and limited by various adverse effects...
August 8, 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28790881/contrasting-coping-styles-meet-the-wall-a-dopamine-driven-dichotomy-in-behavior-and-cognition
#17
Erik Höglund, Patricia I M Silva, Marco A Vindas, Øyvind Øverli
Individual variation in the ability to modify previously learned behavior is an important dimension of trait correlations referred to as coping styles, behavioral syndromes or personality. These trait clusters have been shaped by natural selection, and underlying control mechanisms are often conserved throughout vertebrate evolution. In teleost fishes, behavioral flexibility and coping style have been studied in the high (HR) and low-responsive (LR) rainbow trout lines. Generally, proactive LR trout show a behavior guided by previously learned routines, while HR trout show a more flexible behavior relying on environmental cues...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28783372/effects-of-aromatherapy-massage-on-pregnant-women-s-stress-and-immune-function-a-longitudinal-prospective-randomized-controlled-trial
#18
Pao-Ju Chen, Cheng-Chen Chou, Luke Yang, Yu-Lun Tsai, Yue-Cune Chang, Jen-Jiuan Liaw
OBJECTIVES: This study's aims are to examine the effects of aromatherapy massage on women's stress and immune function during pregnancy. METHODS: This longitudinal, prospective, randomized controlled trial recruited 52 healthy pregnant women from a prenatal clinic in Taipei using convenience sampling. The participants were randomly assigned to the intervention (n = 24) or control (n = 28) group using Clinstat block randomization. The intervention group received 70 min of aromatherapy massage with 2% lavender essential oil every other week (10 times in total) for 20 weeks; the control group received only routine prenatal care...
August 7, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28782310/ecg-changes-in-young-healthy-smokers-a-simple-and-cost-effective-method-to-assess-cardiovascular-risk-according-to-pack-years-of-smoking
#19
Nirmal Kumar Sharma, Kapil Kumar Jaiswal, S R Meena, Rahul Chandel, Saurabh Chittora, Prem Singh Goga, H B Harish, Rajesh Sagar
OBJECTIVE: To document the prevalence of ECG abnormalities in young healthy smokers and compare ECG changes in smokers, young healthy non-smokers and amongst smokers with different pack years. METHODS: This was a prospective case-control study consisting of 200 young healthy male and female individuals, 150 smokers and 50 non-smokers between ages 25-40 years, further categorized and compared according to age, sex and pack years of smoking. The ECG recordings were analyzed for different ECG parameters like heart rate, P-wave duration, P-wave amplitude, PR interval, QRS duration, RR-interval, ST-segment duration, QT interval and QTc interval...
June 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28777662/clinical-and-radiological-regeneration-of-large-and-deep-osteochondral-defects-of-the-knee-by-bone-augmentation-combined-with-matrix-guided-autologous-chondrocyte-transplantation
#20
Johannes Zellner, Stephan Grechenig, Christian G Pfeifer, Werner Krutsch, Matthias Koch, Goetz Welsch, Madeleine Scherl, Johannes Seitz, Florian Zeman, Michael Nerlich, Peter Angele
BACKGROUND: Large osteochondral defects of the knee are a challenge for regenerative treatment. While matrix-guided autologous chondrocyte transplantation (MACT) represents a successful treatment for chondral defects, the treatment potential in combination with bone grafting by cancellous bone or bone block augmentation for large and deep osteochondral defects has not been evaluated. PURPOSE: To evaluate 1- to 3-year clinical outcomes and radiological results on magnetic resonance imaging (MRI) after the treatment of large osteochondral defects of the knee with bone augmentation and MACT...
August 1, 2017: American Journal of Sports Medicine
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