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https://www.readbyqxmd.com/read/29471605/-emerging-therapies-what-are-promising-in-the-near-future
#1
REVIEW
Geom Seog Seo, Sung Hee Lee
The treatment of inflammatory bowel disease has evolved with the development of anti-TNF agents. In spite of long-term effectiveness, many patients do not respond or no longer responds to these drugs. Therefore, the development of new drugs that act on different inflammatory pathways has become necessary. Vedolizumab, a gut-specific biological agent, inhibits interaction α4β7 integrin with mucosal addressin cell adhesion molecule-1 without inhibiting systemic immune responses. Long-term vedolizumab therapy in patients with Crohn's disease and ulcerative colitis was safe and effective...
February 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29469550/chest-wall-blocks-and-minimally-invasive-image-guide-procedures-the-meeting-point-between-radiology-and-anesthesiology-that-could-improve-safety-and-patient-outcomes-in-nora
#2
Pierfrancesco Fusco, Stefano DI Carlo, Marco Vespasiano, Paolo Scimia, Emiliano Petrucci, Luigi Panella, Franco Marinangeli
No abstract text is available yet for this article.
February 15, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29468508/ultrasound-guided-bilateral-superficial-cervical-block-and-preemptive-single-dose-oral-tizanidine-for-post-thyroidectomy-pain-a-randomized-controlled-double-blind-study
#3
Ali Ahiskalioglu, Ahmet Murat Yayik, Elif Oral Ahiskalioglu, Aysenur Dostbil, Omer Doymus, Erdem Karadeniz, Muhammet Ali Ari, Furkan Sengoz, Haci Ahmet Alici, Erkan Cem Celik
PURPOSES: The postoperative analgesic effect of tizanidine has not yet been evaluated sufficiently. The role of bilateral superficial cervical plexus block (BSCPB) for postoperative analgesia after thyroidectomy remains questionable. We aimed to evaluate the analgesic effect of combined use of BSCPB and a single-dose oral tizanidine in patients undergoing elective thyroid surgery. METHODS: Sixty patients undergoing thyroidectomy were randomized into 3 groups. The control group (Group C, n = 20) received BSCPB with 0...
February 21, 2018: Journal of Anesthesia
https://www.readbyqxmd.com/read/29468463/detecting-seasonal-and-cyclical-trends-in-agricultural-runoff-water-quality-hypothesis-tests-and-block-bootstrap-power-analysis
#4
Venkatesh Uddameri, Sreeram Singaraju, E Annette Hernandez
Seasonal and cyclic trends in nutrient concentrations at four agricultural drainage ditches were assessed using a dataset generated from a multivariate, multiscale, multiyear water quality monitoring effort in the agriculturally dominant Lower Rio Grande Valley (LRGV) River Watershed in South Texas. An innovative bootstrap sampling-based power analysis procedure was developed to evaluate the ability of Mann-Whitney and Noether tests to discern trends and to guide future monitoring efforts. The Mann-Whitney U test was able to detect significant changes between summer and winter nutrient concentrations at sites with lower depths and unimpeded flows...
February 21, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29467693/sensorimotor-learning-during-a-marksmanship-task-in-immersive-virtual-reality
#5
Hrishikesh M Rao, Rajan Khanna, David J Zielinski, Yvonne Lu, Jillian M Clements, Nicholas D Potter, Marc A Sommer, Regis Kopper, Lawrence G Appelbaum
Sensorimotor learning refers to improvements that occur through practice in the performance of sensory-guided motor behaviors. Leveraging novel technical capabilities of an immersive virtual environment, we probed the component kinematic processes that mediate sensorimotor learning. Twenty naïve subjects performed a simulated marksmanship task modeled after Olympic Trap Shooting standards. We measured movement kinematics and shooting performance as participants practiced 350 trials while receiving trial-by-trial feedback about shooting success...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29462058/comparison-of-paravertebral-block-by-anatomic-landmark-technique-to-ultrasound-guided-paravertebral-block-for-breast-surgery-anesthesia-a-randomized-controlled-trial
#6
Rupali Patnaik, Anjolie Chhabra, Rajeshwari Subramaniam, Mahesh K Arora, Devalina Goswami, Anurag Srivastava, Vuthaluru Seenu, Anita Dhar
BACKGROUND AND OBJECTIVES: Paravertebral block (PVB) is an established technique for providing anesthesia for breast surgery. The primary objective was to compare anatomical landmark technique (ALT) to the ultrasound-guided (USG) PVB block for providing surgical anesthesia. Secondary objectives included comparison of perioperative analgesia and complications. METHODS: This randomized, controlled, observer-blinded study included 72 females, aged 18 to 65 years, American Society of Anesthesiologists physical status I or II, undergoing elective unilateral breast surgery...
February 16, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29461997/best-worst-scaling-to-prioritize-outcomes-meaningful-to-caregivers-of-youth-with-mental-health-multimorbidities-a-pilot-study
#7
Wendy Camelo Castillo, Melissa Ross, Saad Tariq, Susan dosReis
OBJECTIVE: Health care decision-making for youth with mental health multimorbidity is guided by outcomes that are considered most meaningful and important. The study objective was to pilot test a best-worst scaling (BWS) instrument designed to assess trade-offs among caregiver-defined, meaningful health care outcomes. METHODS: A BWS was designed with continuous stakeholder involvement to elicit caregiver-defined outcomes in 4 domains: school, behavioral, social, and independence...
February 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29461080/appraisal-driven-facial-actions-as-building-blocks-for-emotion-inference
#8
Klaus R Scherer, Marcello Mortillaro, Irene Rotondi, Ilaria Sergi, Stéphanie Trznadel
Although research on facial emotion recognition abounds, there has been little attention on the nature of the underlying mechanisms. In this article, using a "reverse engineering" approach, we suggest that emotion inference from facial expression mirrors the expression process. As a strong case can be made for an appraisal theory account of emotional expression, which holds that appraisal results directly determine the nature of facial muscle actions, we claim that observers first detect specific appraisals from different facial muscle actions and then use implicit inference rules to categorize and name specific emotions...
March 2018: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/29457395/-effects-of-patient-controlled-infraclavicular-brachial-plexus-block-for-postoperative-pain-and-surgical-efficacy-in-patients-with-terrible-tyriad-of-the-elbow
#9
Wang Xiu-Zhen, Ye-Ying Ge, Guang-Yao Ye, Jing-Wei Zhang, Wei-Hu Ma
OBJECTIVE: To study the effects of ultrasound guided inter-scalene brachial plexus block and patient-controlled infraclavicular brachial plexus block for postoperative pain and surgical efficacy in patients with terrible tyriad of the elbow. METHODS: From March 2015 to August 2016, 60 patients with terrible tyriad of the elbows were treated in Ningbo No.6 Hospital with ASA I to II internal fixation. There were 32 males and 28 females, ranging in age from 16 to 70 years old, with a mean age of (55...
November 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457120/spread-of-injectate-in-ultrasound-guided-serratus-plane-block-a-cadaveric-study
#10
Tatsuya Kunigo, Takeshi Murouchi, Shuji Yamamoto, Michiaki Yamakage
Background: Serratus plane block is a thoracic truncal block that has been proposed as alternatives for analgesia such as epidural anesthesia and paravertebral block for the anterolateral chest wall. Previously, we performed the clinical study about optimal volume of the local anesthetic in serratus plane block. The primary aim of this study was to assess the pattern of distribution of dye into the serratus plane of cadavers after ultrasound-guided serratus plane injection. Findings: Ultrasound-guided serratus plane injection was performed at the level of the fourth rib on the mid-axillary line in nine adult Thiel-embalmed cadavers...
2018: JA Clin Rep
https://www.readbyqxmd.com/read/29456952/clinicopathological-significance-of-tumor-lymphatic-vessel-density-in-head-and-neck-squamous-cell-carcinoma
#11
Padam Parmar, Nisha Marwah, Sanjeev Parshad, Taruna Yadav, Ashima Batra, Rajeev Sen
Various studies have demonstrated that the lymphatic system is the additional route for solid tumor metastasis. Lymph nodes metastasis in Head and neck squamous cell carcinoma (HNSCC) is a major prognostic indicator for disease progression and a guide for therapeutic strategies. We conducted a study to compare intratumoral (IT) and peritumoral (PT) lymphatic vessel density (LVD) in HNSCC using lymphatic marker D2-40 and its correlation with lymph node metastasis, histological grading and other clinicopathological parameters...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456706/comparison-of-single-and-triple-injection-methods-for-ultrasound-guided-interscalene-brachial-plexus-blockade
#12
Cun-Jin Wang, Ya-Li Ge, Ju Gao, Feng-Yun Long, Zhi-Hua Mi, Tian-Feng Huang, Xiang-Zhi Fang, Xiao-Ping Chen, Yu-Si Hua, Yang Zhang
Ultrasound-guided interscalene brachial plexus blockade (IBPB) has a relatively high success rate in shoulder surgery; however, whether multiple injections are superior to a single injection (SI) is currently unknown. In the present study, ultrasound-guided SI and triple-injection (TI) IBPBs were compared in a prospective randomized trial. A total of 111 patients undergoing arthroscopic shoulder surgery and presenting with an American Society of Anesthesiologists physical status grading of I-II were randomly allocated to receive IBPB with 15 ml of 1% ropivacaine as a SI or TI...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456189/programmable-rna-cleavage-and-recognition-by-a-natural-crispr-cas9-system-from-neisseria-meningitidis
#13
Beth A Rousseau, Zhonggang Hou, Max J Gramelspacher, Yan Zhang
The microbial CRISPR systems enable adaptive defense against mobile elements and also provide formidable tools for genome engineering. The Cas9 proteins are type II CRISPR-associated, RNA-guided DNA endonucleases that identify double-stranded DNA targets by sequence complementarity and protospacer adjacent motif (PAM) recognition. Here we report that the type II-C CRISPR-Cas9 from Neisseria meningitidis (Nme) is capable of programmable, RNA-guided, site-specific cleavage and recognition of single-stranded RNA targets and that this ribonuclease activity is independent of the PAM sequence...
February 14, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29454333/comparative-study-of-ultrasound-guided-paravertebral-block-versus-intravenous-tramadol-for-postoperative-pain-control-in-percutaneous-nephrolithotomy
#14
Zehra Hatipoglu, Ersel Gulec, Mediha Turktan, Volkan Izol, Atilla Arıdogan, Yasemin Gunes, Dilek Ozcengiz
BACKGROUND: Percutaneous nephrolithotomy (PCNL) is a minimally invasive surgical procedure for renal calculi, and nephrostomy tubes lead to postoperative pain after PCNL. Regional techniques (e.g., epidural analgesia and peripheral blocks) and opioids are applied for postoperative pain treatment. The aim of this study was to compare effectiveness of ultrasound-guided paravertebral block (PVB) and tramadol on postoperative pain in patients who underwent PCNL. METHOD: Fifty-three patients were included in this prospective randomized study...
February 17, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29447209/haplotype-based-genome-wide-association-study-identifies-loci-and-candidate-genes-for-milk-yield-in-holsteins
#15
Zhenliang Chen, Yunqiu Yao, Peipei Ma, Qishan Wang, Yuchun Pan
Since milk yield is a highly important economic trait in dairy cattle, the genome-wide association study (GWAS) is vital to explain the genetic architecture underlying milk yield and to perform marker-assisted selection (MAS). In this study, we adopted a haplotype-based empirical Bayesian GWAS to identify the loci and candidate genes for milk yield. A total of 1 092 Holstein cows were sequenced by using the genotyping by genome reducing and sequencing (GGRS) method. After filtering, 164 312 high-confidence SNPs and 13 476 haplotype blocks were identified to use for GWAS...
2018: PloS One
https://www.readbyqxmd.com/read/29446301/plasmon-waveguiding-in-nanowires
#16
Hong Wei, Deng Pan, Shunping Zhang, Zhipeng Li, Qiang Li, Ning Liu, Wenhui Wang, Hongxing Xu
Nanowires supporting propagating surface plasmons can function as nanowaveguides to realize the light guiding with field confinement beyond the diffraction limit, providing fundamental building blocks for nanophotonic integrated circuits. This review covers the recent developments of plasmon waveguiding in nanowires, mainly including plasmon waveguiding in metal nanowires, coupling of nanowire plasmons and emitters, hybrid nanowire waveguides and plasmonic gain, and nanowire photonic devices. We first introduce the main techniques for fabricating metal nanowires, the plasmon modes in metal nanowires and the excitation/detection methods...
February 15, 2018: Chemical Reviews
https://www.readbyqxmd.com/read/29445501/saphenous-nerve-block-as-a-diagnosis-tool-for-chronic-postsurgical-pain-of-the-left-medial-calf
#17
Dan Sebastian Dîrzu, Theodor Boţ, Constantin Ciuce
Ultrasound-guided saphenous nerve block above the knee may be a valuable diagnosis tool in patient presenting chronic pain of the calf.
February 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29445296/the-ultrasound-guided-retrolaminar-block-volume-dependent-injectate-distribution
#18
Marija Damjanovska, Tatjana Stopar Pintaric, Erika Cvetko, Kamen Vlassakov
Purpose: The ultrasound-guided retrolaminar block is one of the newer and simpler alternatives to the traditional, often technically challenging, paravertebral (PV) block. Its feasibility, safety, and efficacy have already been clinically demonstrated in patients with multiple rib fractures using higher volumes of local anesthetic, when compared with the traditional approach. The primary aim of this observational anatomical study was to assess the spread of local anesthetic from the retrolaminar injection point to the PV space and its volume dependence...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29444854/bet-bromodomain-proteins-regulate-enhancer-function-during-adipogenesis
#19
Jonathan D Brown, Zachary B Feldman, Sean P Doherty, Jaime M Reyes, Peter B Rahl, Charles Y Lin, Quanhu Sheng, Qiong Duan, Alexander J Federation, Andrew L Kung, Saptarsi M Haldar, Richard A Young, Jorge Plutzky, James E Bradner
Developmental transitions are guided by master regulatory transcription factors. During adipogenesis, a transcriptional cascade culminates in the expression of PPARγ and C/EBPα, which orchestrate activation of the adipocyte gene expression program. However, the coactivators controlling PPARγ and C/EBPα expression are less well characterized. Here, we show the bromodomain-containing protein, BRD4, regulates transcription of PPARγ and C/EBPα. Analysis of BRD4 chromatin occupancy reveals that induction of adipogenesis in 3T3L1 fibroblasts provokes dynamic redistribution of BRD4 to de novo super-enhancers proximal to genes controlling adipocyte differentiation...
February 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29443081/recombinant-collagen-i-peptide-microcarriers-for-cell-expansion-and-their-potential-use-as-cell-delivery-system-in-a-bioreactor-model
#20
Melva Suarez Muñoz, Davide Confalonieri, Heike Walles, Elisabeth M W M van Dongen, Gudrun Dandekar
Tissue engineering is a promising field, focused on developing solutions for the increasing demand on tissues and organs regarding transplantation purposes. The process to generate such tissues is complex, and includes an appropriate combination of specific cell types, scaffolds, and physical or biochemical stimuli to guide cell growth and differentiation. Microcarriers represent an appealing tool to expand cells in a three-dimensional (3D) microenvironment, since they provide higher surface-to volume ratios and mimic more closely the in vivo situation compared to traditional two-dimensional methods...
February 7, 2018: Journal of Visualized Experiments: JoVE
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