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https://www.readbyqxmd.com/read/28719457/regional-anesthesia-in-diabetic-peripheral-neuropathy
#1
Werner Ten Hoope, Marjolein Looije, Philipp Lirk
PURPOSE OF REVIEW: The aim of this review is to summarize recent relevant literature regarding regional anesthesia in the diabetic neuropathic patient and formulate recommendations for clinical practice. RECENT FINDINGS: Diabetic neuropathic nerves, but not nerves of diabetic patients per se, exhibit complex functional changes. As a result, they seem more sensitive to local anesthetics, and are more difficult to stimulate. When catheters are used postoperatively, diabetes is an independent risk factor for infection...
July 15, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28714559/how-we-make-dna-origami
#2
Klaus F Wagenbauer, Floris A S Engelhardt, Evi K Stahl, Vera K Hechtl, Pierre Stömmer, Fabian Seebacher, Letizia Meregalli, Philip Ketterer, Thomas Gerling, Hendrik Dietz
DNA ORIGAMI has attracted substantial attention since its invention ten years ago due to the seemingly infinite possibilities that it affords for creating customized nanoscale objects. While the basic concept of DNA origami is easy to understand, using custom DNA origami in practical applications requires detailed know-how for designing and producing the particles with sufficient quality, and preparing them at appropriate concentrations with the necessary degree of purity in custom environments. Such know-how is not readily available for newcomers to the field, thus slowing down the rate at which new applications outside the field of DNA nanotechnology may emerge...
July 17, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28714206/efficacy-of-ultrasound-and-nerve-stimulation-guidance-in-peripheral-nerve-block-a-systematic-review-and-meta-analysis
#3
Zhi-Xue Wang, De-Li Zhang, Xin-Wei Liu, Yan Li, Xiao-Xia Zhang, Ru-Hong Li
Evidence was controversial about whether nerve stimulation (NS) can optimize ultrasound guidance (US)-guided nerve blockade for peripheral nerve block. This review aims to explore the effects of the two combined techniques. We searched EMBASE (from 1974 to March 2015), PubMed (from 1966 to Mar 2015), Medline (from 1966 to Mar 2015), the Cochrane Central Register of Controlled Trials and clinicaltrials.gov. Finally, 15 randomized trials were included into analysis involving 1,019 lower limb and 696 upper limb surgery cases...
July 16, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28712103/randomised-controlled-trial-of-analgesic-effectiveness-of-three-different-techniques-of-single-shot-interscalene-brachial-plexus-block-using-20-ml-of-0-5-ropivacaine-for-shoulder-arthroscopy
#4
Michał Jan Stasiowski, Michał Kolny, Marek Zuber, Radosław Marciniak, Ewa Chabierska, Przemysław Jałowiecki, Aleksandra Pluta, Bartłomiej Możdżyński
Background Shoulder arthroscopic procedures impose a challenge to anaesthesiologists in terms of postoperative analgesia. Proper pain management after arthroscopic procedures improves patient satisfaction and facilitates early rehabilitation. METHODS: We performed a randomized, prospective clinical study to assess the influence of anthropometric parameters and IBPB technique on the quality of postoperative analgesia. A total of 106 randomly selected patients of ASA I-III status scheduled for elective shoulder arthroscopy ...
July 16, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/28710081/use-of-a-next-generation-multi-durometer-long-guide-sheath-for-triaxial-access-in-flow-diversion-experience-in-95-consecutive-cases
#5
Li-Mei Lin, Matthew T Bender, Geoffrey P Colby, Narlin B Beaty, Bowen Jiang, Jessica K Campos, Judy Huang, Rafael J Tamargo, Alexander L Coon
BACKGROUND: Intracranial access techniques in modern neurointerventions have shifted towards more robust access platforms. The long guide sheath is one of the building blocks of triaxial systems used in intracranial embolizations. Here we present our experience with the AXS Infinity LS long sheath in the triaxial platform for the implantation of the Pipeline embolization device (PED). METHODS: We retrospectively identified patients who underwent PED Flex treatment with the AXS Infinity LS at a single institution...
July 14, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28707211/high-accuracy-drilling-with-an-image-guided-light-weight-robot-autonomous-versus-intuitive-feed-control
#6
Sebastian Tauscher, Alexander Fuchs, Fabian Baier, Lüder A Kahrs, Tobias Ortmaier
PURPOSE: Assistance of robotic systems in the operating room promises higher accuracy and, hence, demanding surgical interventions become realisable (e.g. the direct cochlear access). Additionally, an intuitive user interface is crucial for the use of robots in surgery. Torque sensors in the joints can be employed for intuitive interaction concepts. Regarding the accuracy, they lead to a lower structural stiffness and, thus, to an additional error source. The aim of this contribution is to examine, if an accuracy needed for demanding interventions can be achieved by such a system or not...
July 13, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28702394/osteoid-osteoma-radiofrequency-ablation-treatment-guided-by-computed-tomography-a-case-series
#7
Rosana Raquel Endo, Natalia Fabris Gama, Suely Akiko Nakagawa, Chiang Jeng Tyng, Wu Tu Chung, Fábio Fernando Eloi Pinto
The osteoid osteoma is a benign primary bone tumor that affects mainly males in the second and third decades of life. Radiographic findings show a radiolucent nidus surrounded by reactive sclerotic bone, particularly in the long bones of the lower extremity. Clinically, it presents persistent pain, which is worse at night and improves with salicylates. It can be a self-limiting injury, with an average duration of three years, but because of pain intensity and intolerance to prolonged use of nonsteroidal anti-inflammatories, surgical treatment is an option...
May 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28701825/role-of-cell-block-in-cytopathologic-evaluation-of-image-guided-fine-needle-aspiration-cytology
#8
Elizabath P Mathew, Vijayalakshmi Nair
CONTEXT: Fine needle aspiration cytology (FNAC) of superficial or deep-seated lesion is an increasingly common practice, eliminating time consuming and costly diagnostic procedures and providing rapid and safe diagnosis. AIMS: To assess utility of cell block preparation method in increasing sensitivity of cytodiagnosis in deep-seated image-guided FNACs. SETTINGS AND DESIGN: This was a hospital-based observational study conducted in the Department of Pathology, over a period of one and a half years...
July 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28701034/a-site-cation-effect-on-growth-thermodynamics-and-photoconductive-properties-in-ultra-pure-lead-iodine-perovskite-monocrystalline-wires
#9
Ligang Wang, Yuan Huang, Aashir Waleed, Ke Wu, Cong Lin, Zhengxu Wang, Guanhaojie Zheng, Zhiyong Fan, Junliang Sun, Huanping Zhou, Lingdong Sun, Chun-Hua Yan
Among the various building blocks beyond polycrystalline thin films, perovskite wires have attracted extensive attention for potential applications including nano-lasers, wave-guides, field effect transistors, and more. In this work, millimeter-scale lead iodine-based perovskite wires employing various A-site substitutions, namely, Cs, methylammonium (MA), and formamidinium (FA), have been synthesized via a new type solution method with nearly 100% yield. All three millimeter-scale perovskite wires (MPWs) compositions exhibit relatively high quality, and CsPbI3 is proven to be monocrystalline along its entire length...
July 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28698888/modulation-of-complex-spike-duration-and-probability-during-cerebellar-motor-learning-in-visually-guided-smooth-pursuit-eye-movements-of-monkeys
#10
Yan Yang, Stephen G Lisberger
Activation of an inferior olivary neuron powerfully excites Purkinje cells via its climbing fiber input and triggers a characteristic high-frequency burst, known as the complex spike (CS). The theory of cerebellar learning postulates that the CS induces long-lasting depression of the strength of synapses from active parallel fibers onto Purkinje cells, and that synaptic depression leads to changes in behavior. Prior reports showed that a CS on one learning trial is linked to a properly timed depression of simple spikes on the subsequent trial, as well as a learned change in pursuit eye movement...
May 2017: ENeuro
https://www.readbyqxmd.com/read/28694335/prior-cocaine-self-administration-increases-response-outcome-encoding-that-is-divorced-from-actions-selected-in-dorsal-lateral-striatum
#11
Amanda C Burton, Gregory B Bissonette, Adam C Zhao, Pooja K Patel, Matthew R Roesch
Dorsal lateral striatum (DLS) is a highly associative structure which encodes relationships between environmental stimuli, behavioral responses, and predicted outcomes. DLS is known to be disrupted after chronic drug abuse, however it remains unclear what neural signals in DLS are altered. Current theory suggests that drug use enhances stimuli-response processing at the expense of response-outcome encoding, but this has mostly been tested in simple behavioral tasks. Here, we ask what neural correlates in DLS are affected by previous cocaine exposure as rats perform a complex reward-guided decision-making task where predicted reward value was independently manipulated by changing the delay to or size of reward associated with a response direction across a series of trial blocks...
July 10, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28692038/par-terra-directs-homologous-sex-chromosome-pairing
#12
Hsueh-Ping Chu, John E Froberg, Barry Kesner, Hyun Jung Oh, Fei Ji, Ruslan Sadreyev, Stefan F Pinter, Jeannie T Lee
In mammals, homologous chromosomes rarely pair outside meiosis. One exception is the X chromosome, which transiently pairs during X-chromosome inactivation (XCI). How two chromosomes find each other in 3D space is not known. Here, we reveal a required interaction between the X-inactivation center (Xic) and the telomere in mouse embryonic stem (ES) cells. The subtelomeric, pseudoautosomal regions (PARs) of the two sex chromosomes (X and Y) also undergo pairing in both female and male cells. PARs transcribe a class of telomeric RNA, dubbed PAR-TERRA, which accounts for a vast majority of all TERRA transcripts...
July 10, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28688136/ultrasound-versus-traditional-palpation-to-guide-radial-artery-cannulation-in-critically-ill-children-a-randomized-trial
#13
Nattachai Anantasit, Pimporn Cheeptinnakorntaworn, Anant Khositseth, Rojjanee Lertbunrian, Marut Chantra
OBJECTIVES: To identify success rates for radial artery cannulation in a pediatric critical care unit using either palpation or ultrasound guidance to cannulate the radial artery. METHODS: A prospective randomized comparative study of critically ill children who required invasive monitoring in a tertiary referral center was conducted. All patients were randomized by a stratified block of 4 to either ultrasound-guided or traditional palpation radial artery cannulation...
July 8, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28687915/revised-propeller-for-t2-weighted-imaging-of-the-prostate-at-3-tesla-impact-on-lesion-detection-and-pi-rads-classification
#14
Michael Meier-Schroers, Christian Marx, Frederic Carsten Schmeel, Karsten Wolter, Jürgen Gieseke, Wolfgang Block, Alois Martin Sprinkart, Frank Traeber, Winfried Willinek, Hans Heinz Schild, Guido Matthias Kukuk
PURPOSE: To evaluate revised PROPELLER (RevPROP) for T2-weighted imaging (T2WI) of the prostate as a substitute for turbo spin echo (TSE). MATERIALS AND METHODS: Three-Tesla MR images of 50 patients with 55 cancer-suspicious lesions were prospectively evaluated. Findings were correlated with histopathology after MRI-guided biopsy. T2 RevPROP, T2 TSE, diffusion-weighted imaging, dynamic contrast enhancement, and MR-spectroscopy were acquired. RevPROP was compared to TSE concerning PI-RADS scores, lesion size, lesion signal-intensity, lesion contrast, artefacts, and image quality...
July 7, 2017: European Radiology
https://www.readbyqxmd.com/read/28686273/photosensitizer-ps-polyhedral-oligomeric-silsesquioxane-poss-crosslinked-nanohybrids-for-enhanced-imaging-guided-photodynamic-cancer-therapy
#15
Ya-Xuan Zhu, Hao-Ran Jia, Zhan Chen, Fu-Gen Wu
Photodynamic therapy (PDT) has drawn extensive attention as a promising cancer treatment modality. However, most PDT nanoagents suffer from insufficient drug loading capacity, a severe self-quenching effect, premature release of drugs and/or potential toxicity. Herein, we rationally designed an inorganic-organic nanohybrid with high drug loading capacity and superior chemical stability for enhanced PDT. Polyhedral oligomeric silsesquioxane (POSS), an amine-containing cage-shaped building block, was crosslinked with chlorin e6 (Ce6), a carboxyl-containing photosensitizer, via the amine-carboxyl reaction...
July 7, 2017: Nanoscale
https://www.readbyqxmd.com/read/28685458/electron-paramagnetic-resonance-po2-image-tumor-oxygen-guided-radiation-therapy-optimization
#16
Boris Epel, Matt Maggio, Charles Pelizzari, Howard J Halpern
Modern standards for radiation treatment do not take into account tumor oxygenation for radiation treatment planning. Strong correlation between tumor oxygenation and radiation treatment success suggests that oxygen-guided radiation therapy (OGRT) may be a promising enhancement of cancer radiation treatment. We have developed an OGRT protocol for rodents. Electron paramagnetic resonance (EPR) imaging is used for recording oxygen maps with high spatial resolution and excellent accuracy better than 1 torr. Radiation is delivered with an animal intensity modulated radiation therapy (IMRT) XRAD225Cx micro-CT/ therapy system...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28682892/in-patients-undergoing-fast-track-total-knee-arthroplasty-addition-of-buprenorphine-to-a-femoral-nerve-block-has-no-clinical-advantage-a-prospective-double-blinded-randomized-placebo-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Rienk van Beek, Harry J Zonneveldt, Tjeerd van der Ploeg, Jeroen Steens, Phillip Lirk, Marcus W Hollmann
BACKGROUND: Several adjuvants have been proposed to prolong the effect of peripheral nerve blocks, one of which is buprenorphine. In this randomized double blinded placebo controlled trial we studied whether the addition of buprenorphine to a femoral nerve block prolongs analgesia in patients undergoing total knee arthroplasty in a fast track surgery protocol. METHODS: The treatment group (B) was given an ultrasound-guided femoral nerve block with ropivacaine 0...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28682306/unique-roles-for-histone-h3k9me-states-in-rnai-and-heritable-silencing-of-transcription
#18
Gloria Jih, Nahid Iglesias, Mark A Currie, Natarajan V Bhanu, Joao A Paulo, Steven P Gygi, Benjamin A Garcia, Danesh Moazed
Heterochromatic DNA domains play important roles in regulation of gene expression and maintenance of genome stability by silencing repetitive DNA elements and transposons. From fission yeast to mammals, heterochromatin assembly at DNA repeats involves the activity of small noncoding RNAs (sRNAs) associated with the RNA interference (RNAi) pathway(1-9). Typically, sRNAs, originating from long noncoding RNAs, guide Argonaute-containing effector complexes to complementary nascent RNAs to initiate histone H3 lysine 9 di- and tri-methylation (H3K9me2 and H3K9me3, respectively) and heterochromatin formation(10-17)...
June 22, 2017: Nature
https://www.readbyqxmd.com/read/28679202/the-ultrasound-guided-transmuscular-quadratus-lumborum-block-for-perioperative-analgesia-in-open-nephrectomy-a-case-report
#19
Ruggero M Corso, Emanuele Piraccini, Massimiliano Sorbello, Daniele Bellantonio, Mario Tedesco
No abstract text is available yet for this article.
July 5, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28679199/ultrasound-guided-genitofemoral-nerve-block-for-inguinal-hernia-repair-in-the-male-adult-a-randomized-controlled-pilot-study
#20
Luciano Frassanito, Bruno A Zanfini, Sara Pitoni, Paolo Germini, Miryam Del Vicario, Gaetano Draisci
BACKGROUND: Ultrasound-guided (USG) ilioinguinal/iliohypogastric nerve (II/IHN) block is a widely validated anesthetic technique for inguinal herniorrhaphy. As the spermatic cord, scrotum, and adjacent thigh receive sensory innervation from the genital branch of genitofemoral nerve (GFN), the addition of GFN block has been suggested to improve the quality of perioperative anesthesia and analgesia. The aim of this study is to compare GFN block plus II/IHN block with II/IHN block alone for intraoperative anesthesia and post-operative pain management...
July 5, 2017: Minerva Anestesiologica
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