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https://www.readbyqxmd.com/read/28643171/elimination-of-the-negative-component-of-the-unipolar-electrogram-as-a-local-procedural-endpoint-during-paroxysmal-atrial-fibrillation-catheter-ablation-using-contact-force-sensing-the-uniforce-study
#1
Agustín Bortone, Philippe Lagrange, Bruno Cauchemez, Cyril Durand, Pierre Dieuzaide, Sébastien Prévot, Alexis Mechulan, Thomas Pambrun, Ruairidh Martin, Pauline Parlier, Alexandre Masse, Eloi Marijon, Jean-Paul Albenque
PURPOSE: Elimination of the negative component of the unipolar atrial electrogram is a reliable indicator of the creation of a transmural lesion. Contact-force (CF) sensing technology has the potential to increase the durability of pulmonary vein isolation (PVI). In the present multicenter study, we assessed the 2-year sinus rhythm (SR) maintenance rate in patients with paroxysmal atrial fibrillation (PAF) after PVI guided by these two approaches. METHODS: Two hundred fifteen consecutive PAF patients (62...
June 22, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28642770/interplay-between-carotenoids-abscisic-acid-and-jasmonate-guides-the-compatible-rice-meloidogyne-graminicola-interaction
#2
Tina Kyndt, Kamrun Nahar, Ashley Haeck, Ruben Verbeek, Kristof Demeestere, Godelieve Gheysen
In this study, we have characterized the role of carotenoids and chlorophyll in the compatible interaction between the sedentary root knot nematode (RKN) Meloidogyne graminicola and the monocot model plant rice (Oryza sativa). Previous transcriptome data showed a differential expression of carotenoid and chlorophyll biosynthesis genes in nematode-induced giant cells and gall tissue. Metabolite measurement showed that galls indeed accumulate chlorophyll a, b and carotenoids, as well as the hormone abscisic acid (ABA)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28642724/i-don-t-want-to-miss-a-thing-learning-dynamics-and-effects-of-feedback-type-and-monetary-incentive-in-a-paired-associate-deterministic-learning-task
#3
Magda Gawlowska, Ewa Beldzik, Aleksandra Domagalik, Adam Gagol, Tadeusz Marek, Justyna Mojsa-Kaja
Effective functioning in a complex environment requires adjusting of behavior according to changing situational demands. To do so, organisms must learn new, more adaptive behaviors by extracting the necessary information from externally provided feedback. Not surprisingly, feedback-guided learning has been extensively studied using multiple research paradigms. The purpose of the present study was to test the newly designed Paired Associate Deterministic Learning task (PADL), in which participants were presented with either positive or negative deterministic feedback...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28640075/maximum-voltage-gradient-technique-for-optimization-of-ablation-for-typical-atrial-flutter-with-zero-fluoroscopy-approach
#4
Karol Deutsch, Janusz Śledź, Mariusz Mazij, Bartosz Ludwik, Michał Labus, Dariusz Karbarz, Bernadetta Pasicka, Michał Chrabąszcz, Arkadiusz Śledź, Monika Klank-Szafran, Laura Vitali-Sendoz, Tomasz Kameczura, Jerzy Śpikowski, Piotr Stec, Marek Ujda, Sebastian Stec
Radiofrequency catheter ablation (RFCA) is an established effective method for the treatment of typical cavo-tricuspid isthmus (CTI)-dependent atrial flutter (AFL). The introduction of 3-dimensional electro-anatomic systems enables RFCA without fluoroscopy (No-X-Ray [NXR]). The aim of this study was to evaluate the feasibility and effectiveness of CTI RFCA during implementation of the NXR approach and the maximum voltage-guided (MVG) technique for ablation of AFL.Data were obtained from prospective standardized multicenter ablation registry...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28638353/the-effects-of-spatial-endogenous-pre-cueing-across-eccentricities
#5
Jing Feng, Ian Spence
Frequently, we use expectations about likely locations of a target to guide the allocation of our attention. Despite the importance of this attentional process in everyday tasks, examination of pre-cueing effects on attention, particularly endogenous pre-cueing effects, has been relatively little explored outside an eccentricity of 20°. Given the visual field has functional subdivisions that attentional processes can differ significantly among the foveal, perifoveal, and more peripheral areas, how endogenous pre-cues that carry spatial information of targets influence our allocation of attention across a large visual field (especially in the more peripheral areas) remains unclear...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28636951/structure-of-cc-chemokine-receptor-5-with-a-potent-chemokine-antagonist-reveals-mechanisms-of-chemokine-recognition-and-molecular-mimicry-by-hiv
#6
Yi Zheng, Gye Won Han, Ruben Abagyan, Beili Wu, Raymond C Stevens, Vadim Cherezov, Irina Kufareva, Tracy M Handel
CCR5 is the primary chemokine receptor utilized by HIV to infect leukocytes, whereas CCR5 ligands inhibit infection by blocking CCR5 engagement with HIV gp120. To guide the design of improved therapeutics, we solved the structure of CCR5 in complex with chemokine antagonist [5P7]CCL5. Several structural features appeared to contribute to the anti-HIV potency of [5P7]CCL5, including the distinct chemokine orientation relative to the receptor, the near-complete occupancy of the receptor binding pocket, the dense network of intermolecular hydrogen bonds, and the similarity of binding determinants with the FDA-approved HIV inhibitor Maraviroc...
June 20, 2017: Immunity
https://www.readbyqxmd.com/read/28634153/beyond-basic-feedback-in-mobile-brief-interventions-designing-sms-message-content-for-delivery-to-young-adults-during-risky-drinking-events
#7
Cassandra J C Wright, Paul M Dietze, Megan S C Lim
BACKGROUND: Brief interventions can reduce alcohol consumption in young people through screening and delivery of personally relevant feedback. Recently, Web and mobile platforms have been harnessed to increase the reach of brief interventions. Existing literature on mobile-based alcohol brief interventions indicates mixed use of theory in developing interventions. There is no research available to guide the development of SMS text messaging (short message service, SMS) interventions delivered during risky drinking events...
June 20, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28632673/the-ultrasound-guided-continuous-erector-spinae-plane-block-for-postoperative-analgesia-in-video-assisted-thoracoscopic-lobectomy
#8
Paolo Scimia, Erika Basso Ricci, Andrea Droghetti, Pierfrancesco Fusco
No abstract text is available yet for this article.
July 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28631459/could-the-new-ultrasound-guided-erector-spinae-plane-block-be-a-valid-alternative-to-paraverteral-block-in-chest-chronic-pain-syndromes
#9
Pierfrancesco Fusco, Stefano DI Carlo, Paolo Scimia, Antonio Luciani, Emiliano Petrucci, Franco Marinangeli
No abstract text is available yet for this article.
June 14, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28630474/nanoassembly-routes-stimulate-conflicting-antibody-quantity-and-quality-for-transmission-blocking-malaria-vaccines
#10
Darren B Leneghan, Kazutoyo Miura, Iona J Taylor, Yuanyuan Li, Jing Jin, Karl D Brune, Martin F Bachmann, Mark Howarth, Carole A Long, Sumi Biswas
Vaccine development efforts have recently focused on enabling strong immune responses to poorly immunogenic antigens, via display on multimerisation scaffolds or virus like particles (VLPs). Typically such studies demonstrate improved antibody titer comparing monomeric and nano-arrayed antigen. There are many such studies and scaffold technologies, but minimal side-by-side evaluation of platforms for both the amount and efficacy of antibodies induced. Here we present direct comparison of three leading platforms displaying the promising malaria transmission-blocking vaccine (TBV) target Pfs25...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28627724/comparative-echogenicity-of-an-epidural-catheter-and-2-new-catheters-designed-for-ultrasound-guided-continuous-peripheral-nerve-blocks
#11
Daniel M Moy, T Edward Kim, T Kyle Harrison, Jody C Leng, Brendan Carvalho, Steven K Howard, Cynthia Shum, Alex Kou, Edward R Mariano
Visualization of the catheter during ultrasound-guided continuous nerve block performance may be difficult but is an essential skill for regional anesthesiologists. The objective of this in vitro study was to evaluate 2 newer catheters designed for enhanced echogenicity and compare them to a widely used catheter not purposely designed for ultrasound guidance. Outcomes were the numbers of first-place rankings among all 3 catheters and scores on individual echogenicity criteria as assessed by 2 blinded reviewers...
June 19, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28627128/signatures-of-soft-sweeps-across-the-dt1-locus-underlying-determinate-growth-habit-in-soybean-glycine-max-l-merr
#12
Limei Zhong, Qiaomei Yang, Xin Yan, Chao Yu, Liu Su, Xifeng Zhang, Youlin Zhu
Determinate growth habit is an agronomically important trait associated with domestication in soybean. Previous studies have demonstrated that the emergence of determinacy is correlated with artificial selection on four non-synonymous mutations in the Dt1 gene. To better understand the signatures of the soft sweeps across the Dt1 locus and track the origins of the determinate alleles, we examined patterns of nucleotide variation in Dt1 and the surrounding genomic region of approximately 800 kb. Four local, asymmetrical hard sweeps on four determinate alleles, sized approximately 660, 120, 220 and 150 kb were identified, which constitute the soft sweeps for the adaptation...
June 19, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28624495/comparison-of-ultrasound-and-electrostimulation-guided-nerve-blocks-of-brachial-plexus-in-dogs
#13
Minori Akasaka, Miki Shimizu
OBJECTIVE: To compare the effectiveness of ultrasound- and electrostimulation-guided nerve blocks of the brachial plexus and to determine whether ultrasound guidance is feasible in conscious dogs. STUDY DESIGN: Blinded, crossover, experimental study. ANIMALS: Six clinically healthy adult Beagle dogs. METHODS: The nerves of the brachial plexus of the right thoracic limb were blocked under ultrasound guidance (UNB) in conscious dogs and under electrostimulation guidance (ENB) in anesthetized dogs with bupivacaine (0...
January 11, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28621528/unsupervised-discovery-and-comparison-of-structural-families-across-multiple-samples-in-untargeted-metabolomics
#14
Justin Johan Jozias van der Hooft, Joe Wandy, Francesca Young, Sandosh Padmanabhan, Konstantinos Gerasimidis, Karl E V Burgess, Michael P Barrett, Simon Rogers
In untargeted metabolomics approaches, the inability to structurally annotate relevant features and map them to biochemical pathways is hampering the full exploitation of many metabolomics experiments. Furthermore, variable metabolic content across samples result in sparse feature matrices that are statistically hard to handle. Here, we introduce MS2LDA+ that tackles both above-mentioned problems. Previously, we presented MS2LDA, which extracts biochemically-relevant molecular substructures ('Mass2Motifs') from a collection of fragmentation spectra as sets of co-occurring molecular fragments and neutral losses, thereby recognizing building blocks of metabolomics...
June 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28621182/-non-intubated-uniportal-video-assisted-thoracic-surgery-vats-lobectomy-as-a-new-procedure-in-our-department
#15
József Furák, Zsolt Szabó, Theodor Horváth, Tibor Géczi, Balázs Pécsy, Tibor Németh, Aurél Ottlakán, Zsolt Molnár, György Lázár
AIM: Due to the emerging experience in VATS (video assisted thoracic surgery) lobectomies, in some centers the so called "non-intubated" VATS lobectomies (NITS - non-intubated thoracic surgery) gained increased authority, during which endotracheal intubation and muscle relaxation of the patient is not carried out, thus surgery is being performed with the patient breathing spontaneously. The recent study deals with our initial experience gained during uniportal NITS VATS lobectomies. PATIENTS AND METHOD: Between 24...
June 2017: Magyar Sebészet
https://www.readbyqxmd.com/read/28617716/hybrid-blocks-for-total-knee-arthroplasty-a-technical-description
#16
David F Johnston, Rakesh V Sondekoppam, Vishal Uppal, James L Howard, Sugantha Ganapathy
This narrative review article aims to examine current evidence of knee innervation in order to develop a technique of targeting pure sensory innervation of the knee joint without compromising motor function. A literature review of knee innervation was performed to gain an anatomic understanding of terminal sensory branches of the relevant target nerves (femoral, obturator, sciatic, and lateral femoral cutaneous). Pure sensory block of the knee joint is challenging due to important contributions from the muscular innervation close to the joint and the variability of nerves afferents contained within and around the adductor canal...
June 14, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28614016/eight-questions-to-ask-before-writing-an-article
#17
Tim Albert
Health professionals often have to write articles for publication in academic journals. Many of them find this difficult and suffer from one or more variations of writer's block. A good way of avoiding these setbacks is to prepare thoroughly for the writing project, and this article proposes eight different questions writers can ask before they start. The first is whether they are in a good position to complete the task, and if not whether they should try to negotiate their way out of the project. If they commit to going ahead, writers should work out where they will find the necessary time, and set deadlines for ensuring that they do...
June 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/28611222/all-angle-negative-refraction-of-highly-squeezed-plasmon-and-phonon-polaritons-in-graphene-boron-nitride-heterostructures
#18
Xiao Lin, Yi Yang, Nicholas Rivera, Josué J López, Yichen Shen, Ido Kaminer, Hongsheng Chen, Baile Zhang, John D Joannopoulos, Marin Soljačić
A fundamental building block for nanophotonics is the ability to achieve negative refraction of polaritons, because this could enable the demonstration of many unique nanoscale applications such as deep-subwavelength imaging, superlens, and novel guiding. However, to achieve negative refraction of highly squeezed polaritons, such as plasmon polaritons in graphene and phonon polaritons in boron nitride (BN) with their wavelengths squeezed by a factor over 100, requires the ability to flip the sign of their group velocity at will, which is challenging...
June 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28611109/an-in-vivo-functional-screen-identifies-jnk-signaling-as-a-modulator-of-chemotherapeutic-response-in-breast-cancer
#19
Matthew Ashenden, Antoinette van Weverwijk, Nirupa Murugaesu, Antony Fearns, James Campbell, Qiong Gao, Marjan Iravani, Clare M Isacke
Chemotherapy remains the mainstay of treatment for advanced breast cancer, however, resistance is an inevitable event for the majority of patients with metastatic disease. Moreover, there is little information available to guide stratification of first line chemotherapy, crucial given the common development of multidrug resistance. Here we describe an in vivo screen to interrogate the response to anthracycline-based chemotherapy in a syngeneic metastatic breast cancer model, and identify JNK signaling as a key modulator of chemotherapy response...
June 13, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28610880/comparison-of-analgesic-efficacy-of-laparoscope-assisted-and-ultrasound-guided-transversus-abdominis-plane-block-after-laparoscopic-colorectal-surgery-a-randomized-single-blind-non-inferiority-trial
#20
Soo Yeun Park, Jun Seok Park, Gyu-Seog Choi, Hye Jin Kim, Suyoung Moon, Jinseok Yeo
BACKGROUND: Transversus abdominis plane (TAP) block has been used as a component of multimodal analgesia following abdominal surgery. We introduced a new laparoscope-assisted TAP (LTAP) block technique using intraperitoneal injection, and compared its analgesic effect to that of an ultrasound-guided AP (UTAP) block in terms of postoperative pain control. STUDY DESIGN: A prospective, randomized, single-blinded non-inferiority clinical trial was conducted with patients undergoing elective laparoscopic colectomy for colon cancer...
June 10, 2017: Journal of the American College of Surgeons
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