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https://www.readbyqxmd.com/read/29914782/a-randomized-trial-comparing-surgeon-administered-intraoperative-transversus-abdominis-plane-block-with-anesthesiologist-administered-transcutaneous-block
#1
D M Narasimhulu, L Scharfman, H Minkoff, B George, P Homel, K Tyagaraj
BACKGROUND: Injection of local anesthetic into the transversus abdominis plane (TAP block) decreases systemic morphine requirements after abdominal surgery. We compared intraoperative surgeon-administered TAP block (surgical TAP) to anesthesiologist-administered transcutaneous ultrasound-guided TAP block (conventional TAP) for post-cesarean analgesia. We hypothesized that surgical TAP blocks would take less time to perform than conventional TAP blocks. METHODS: We performed a randomized trial, recruiting 41 women undergoing cesarean delivery under neuraxial anesthesia, assigning them to either surgical TAP block (n=20) or conventional TAP block (n=21)...
April 27, 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29913895/discriminative-sensory-characteristics-of-the-lateral-femoral-cutaneous-nerve-after-mepivacaine-induced-block
#2
Christian Menzer, Marcus Schley, Roman Rukwied, Martin Schmelz, Martin Dusch, Justus Benrath
Background and objectives Unmyelinated C-fibres comprise the largest group of somatic afferents and have demonstrated a crucial role not only in the perception of high-threshold mechanically, thermally or chemically induced pain, but also in non-harmful low-threshold mechanical stimuli [1,2]. The objective of our study was to characterize differential sensitivity changes of C-fibre related subclasses of high-threshold and low-threshold polymodal nociceptors and low-threshold mechanoreceptors to the local anaesthetic (LA) mepivacaine during nerve block of the purely sensory lateral femoral cutaneous nerve (LFCN) in human...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913831/pulsed-radiofrequency-in-peripheral-posttraumatic-neuropathic-pain-a-double-blind-sham-controlled-randomized-clinical-trial
#3
Ethem Akural, Voitto Järvimäki, Raija Korhonen, Hannu Kautiainen, Maija Haanpää
Background and purpose Pulsed radiofrequency (PRF) is widely used for the treatment of chronic pain, although its mechanism of action is not known. The evidence of efficacy of PRF for neuropathic pain (NP) conditions is limited. A double-blind, randomized, sham-controlled parallel study was conducted to evaluate the efficacy and safety of PRF in the treatment of peripheral posttraumatic NP. Methods Forty-five patients with peripheral posttraumatic NP in their upper or lower limb were randomly assigned to receive PRF or sham treatment to the injured peripheral nerve (s) causing peripheral posttraumatic NP...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913683/psychosocial-aspects-of-everyday-life-with-chronic-musculoskeletal-pain-a-systematic-review
#4
Lotte Nygaard Andersen, Maria Kohberg, Birgit Juul-Kristensen, Lene Gram Herborg, Karen Søgaard, Kirsten Kaya Roessler
Background and objective Chronic pain is a growing phenomenon worldwide. It is considered a medical problem because, besides the socio-economic issues involved, pain is often accompanied by psychosocial problems. Apart from the physical pain, living with chronic pain has many additional consequences. People living with chronic pain generally suffer from other physical and psychological consequences. The impact of chronic pain varies enormously between individuals, but the suffering is frequently pervasive and detrimental...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913392/evaluation-of-ultrasound-guided-erector-spinae-plane-block-for-postoperative-analgesia-in-laparoscopic-cholecystectomy-a-prospective-randomized-controlled-clinical-trial
#5
Serkan Tulgar, Mahmut Sertan Kapakli, Ozgur Senturk, Onur Selvi, Talat Ercan Serifsoy, Zeliha Ozer
STUDY OBJECTIVE: Laparoscopic cholecystectomy (LC) is a commonly performed minimally invasive procedure that has led to a decrease in procedure-related mortality and morbidity. However, LC requires analgesia that blocks both visceral and somatic nerve fibers. In this study, we evaluated the effectiveness of Erector Spinae Plane Block (ESPB) for postoperative analgesia management in LC. DESIGN: Single-blinded, prospective, randomized, efficiency study. SETTING: Tertiary university hospital, postoperative recovery room & ward...
June 15, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29912555/discovery-and-evolution-of-polyoxopalladates
#6
Peng Yang, Ulrich Kortz
Noble metal catalysts, in particular palladium-containing materials, are of prime commercial interest, because of their role as oxidation catalysts in automobile emission-control systems and reforming catalysts for the production of high-octane gasoline. However, despite almost two centuries of research, the precise structure of such materials is still ill-defined on the sub-nanometer scale, which severely limits the understanding of the underlying catalytic mechanisms. As a burgeoning class of structurally well-defined noble metal oxide nanoclusters, polyoxopalladates (POPs) have been highly rated as ideal models to fully decipher the molecular mechanism of noble metal-based catalysis...
June 18, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29912188/dissection-of-enhancer-function-using-multiplex-crispr-based-enhancer-interference-in-cell-lines
#7
Julia B Carleton, Kristofer C Berrett, Jason Gertz
Multiple enhancers often regulate a given gene, yet for most genes, it remains unclear which enhancers are necessary for gene expression, and how these enhancers combine to produce a transcriptional response. As millions of enhancers have been identified, high-throughput tools are needed to determine enhancer function on a genome-wide scale. Current methods for studying enhancer function include making genetic deletions using nuclease-proficient Cas9, but it is difficult to study the combinatorial effects of multiple enhancers using this technique, as multiple successive clonal cell lines must be generated...
June 2, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29911581/real-time-ultrasound-guided-infraorbital-nerve-block-to-treat-trigeminal-neuralgia-using-a-high-concentration-of-tetracaine-dissolved-in-bupivacaine
#8
Kenichi Takechi, Amane Konishi, Kotaro Kikuchi, Shiho Fujioka, Tomomi Fujii, Toshihiro Yorozuya, Koh Kuzume, Takumi Nagaro
Background Trigeminal neuralgia is a neuropathic disorder characterized by episodes of intense pain in the face. Drug therapy is the first choice of treatment. However, in cases where drug therapy are contraindicated due to side effects, patients can get pain relief from lengthy neurosurgical procedures. Alternatively, a peripheral trigeminal nerve block can be easily performed in an outpatient setting. Therefore it is a useful treatment option for the acute paroxysmal period of TN in patients who cannot use drug therapy...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911579/ultrasound-guided-high-concentration-tetracaine-peripheral-nerve-block-effective-and-safe-relief-while-awaiting-more-permanent-intervention-for-tic-douloureux
#9
Axel Sauter, Harald Breivik
No abstract text is available yet for this article.
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29910507/the-right-plane-for-drug-injection-in-ultrasound-guided-erector-spinae-plane-block
#10
Neeeraj Kumar Chaudhary, Swati Singh
No abstract text is available yet for this article.
May 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29910495/effect-of-addition-of-dexamethasone-to-ropivacaine-on-post-operative-analgesia-in-ultrasonography-guided-transversus-abdominis-plane-block-for-inguinal-hernia-repair-a-prospective-double-blind-randomised-controlled-trial
#11
Uma Datt Sharma, Prateek, Himani Tak
Background and Aims: Ultrasonography (USG)-guided transversus abdominis plane (TAP) block is an abdominal field block with high efficacy. This study was undertaken with the aim of determining the effect of the addition of dexamethasone to 0.5% ropivacaine on post-operative analgesia in USG-guided TAP block for inguinal hernia repair. Methods: A double-blind randomised control study was conducted on sixty patients posted for inguinal hernia repair with the American Society of Anesthesiologists physical Status I or II, who were allocated two groups of 30 each...
May 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29908832/cardiac-resynchronization-therapy-guided-by-cardiac-magnetic-resonance-imaging-a-prospective-single-centre-randomized-study-cmr-crt
#12
Radka Kočková, Kamil Sedláček, Dan Wichterle, Viktor Šikula, Jaroslav Tintěra, Helena Jansová, Alena Pravečková, Renata Langová, Lukáš Krýže, Wael El-Husseini, Markéta Segeťová, Josef Kautzner
BACKGROUND: Cardiac resynchronization therapy (CRT) improves symptoms of heart failure (HF), morbidity and mortality in selected population. The aim of the study was to investigate the impact of cardiac magnetic resonance (CMR)-guided left ventricular (LV) lead placement on clinical outcomes and LV reverse remodelling in CRT recipients. METHODS: Patients with CRT indication were randomized for CMR-guided (CMR group) or electrophysiologically guided (EP group) LV lead placement between 2011 and 2014...
June 6, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29908716/ultrasonographical-identification-of-the-superficial-circumflex-iliac-artery-as-a-landmark-for-location-of-the-femoral-nerve-in-dogs
#13
Fernando L Garcia-Pereira, Daniel Boruta, Sharon Tenenbaum, Vaidehi Paranjape
OBJECTIVE: To investigate the utility of identifying the superficial circumflex iliac artery (SCIA) via ultrasound as an anatomical landmark for ultrasound-guided femoral nerve block. STUDY DESIGN: Observational study. ANIMALS: A group of six canine cadavers weighing >20 kg. METHODS: Pelvic limbs from six canine cadavers were examined to study the relationship between the SCIA and the femoral nerve. Ultrasonographic imaging of the SCIA in each limb was obtained with the transducer placed transversely in the medial aspect of the pelvic limb at the inguinal area...
April 13, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29905631/ultrasound-guided-selective-versus-conventional-block-of-the-medial-brachial-cutaneous-and-the-intercostobrachial-nerves-a-randomized-clinical-trial
#14
Philippe Magazzeni, Denis Jochum, Gabriella Iohom, Gérard Mekler, Eliane Albuisson, Hervé Bouaziz
BACKGROUND AND OBJECTIVES: For superficial surgery of anteromedial and posteromedial surfaces of the upper arm, the medial brachial cutaneous nerve (MBCN) and the intercostobrachial nerve (ICBN) must be selectively blocked, in addition to an axillary brachial plexus block. We compared efficacy of ultrasound-guided (USG) versus conventional block of the MBCN and the ICBN. METHODS: Eighty-four patients, undergoing upper limb surgery, were randomized to receive either USG (n = 42) or conventional (n = 42) block of the MBCN and the ICBN with 1% mepivacaine...
June 13, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29905630/ultrasound-guided-percutaneous-peripheral-nerve-stimulation-neuromodulation-of-the-sciatic-nerve-for-postoperative-analgesia-following-ambulatory-foot-surgery-a-proof-of-concept-study
#15
Brian M Ilfeld, Rodney A Gabriel, Engy T Said, Amanda M Monahan, Jacklynn F Sztain, Wendy B Abramson, Bahareh Khatibi, John J Finneran, Pia T Jaeger, Alexandra K Schwartz, Sonya S Ahmed
BACKGROUND AND OBJECTIVES: Percutaneous peripheral nerve stimulation (PNS) is an analgesic modality involving the insertion of a lead through an introducing needle followed by the delivery of electric current. This modality has been reported to treat chronic pain as well as postoperative pain the day following knee surgery. However, it remains unknown if this analgesic technique may be used in ambulatory subjects following foot procedures beginning within the recovery room immediately following surgery, and with only short series of patients reported to date, the only available data are derived from strictly observational studies...
June 13, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29904230/calculation-of-forward-scatter-dose-distribution-at-the-skin-entrance-from-the-patient-table-for-fluoroscopically-guided-interventions-using-a-pencil-beam-convolution-kernel
#16
Sarath Vijayan, Zhenyu Xiong, Chao Guo, Jonathan Troville, Naveed Islam, Stephen Rudin, Daniel R Bednarek
The forward-scatter dose distribution generated by the patient table during fluoroscopic interventions and its contribution to the skin dose is studied. The forward-scatter dose distribution to skin generated by a water table-equivalent phantom and the patient table are calculated using EGS nrc Monte-Carlo and Gafchromic film as a function of x-ray field size and beam penetrability. Forward scatter point spread function's (PSF n ) were generated with EGS nrc from a 1×1 mm simulated primary pencil beam incident on the water model and patient table...
February 2018: Proceedings of SPIE
https://www.readbyqxmd.com/read/29902719/surmounting-the-resistance-against-egfr-inhibitors-through-the-development-of-thieno-2-3-d-pyrimidine-based-dual-egfr-her2-inhibitors
#17
Sandra N Milik, Amal Kamal Abdel-Aziz, Deena S Lasheen, Rabah A T Serya, Saverio Minucci, Khaled A M Abouzid
In light of the emergence of resistance against the currently available EGFR inhibitors, our study focuses on tackling this problem through the development of dual EGFR/HER2 inhibitors with improved enzymatic affinities. Guided by the binding mode of the marketed dual EGFR/HER2 inhibitor, Lapatinib, we proposed the design of dual EGFR/HER2 inhibitors based on the 6-phenylthieno[2,3-d]pyrimidine as a core scaffold and hinge binder. After two cycles of screening aiming to identify the optimum aniline headgroup and solubilizing group, we eventually identified 27b as a dual EGFR/HER2 inhibitor with IC50 values of 91...
June 6, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29901680/magnetic-nanoparticle-containing-soft-hard-diblock-copolymer-films-with-high-order
#18
Senlin Xia, Lin Song, Volker Körstgens, Matthias Opel, Matthias Schwartzkopf, Stephan V Roth, Peter Müller-Buschbaum
For sensor applications, superparamagnetic anisotropy is an indispensable property, which is typically achieved by employing an external field to guide the arrangement of magnetic nanoparticles (NPs). In the present investigation, the diblock copolymer polystyrene-block-poly(N-isopropylacrylamide) (PS-b-PNIPAM) is printed as a template to localize magnetic iron oxide NPs without any external field. Via microphase separation, cylindrical nanostructures of PS in a PNIPAM matrix are obtained, aligned perpendicular to the substrate...
June 14, 2018: Nanoscale
https://www.readbyqxmd.com/read/29901627/comparison-of-endoscopic-ultrasound-guided-fine-needle-aspiration-and-biopsy-with-22-gauge-and-25-gauge-needles-for-the-precision-medicine-of-pancreatic-cancer-a-retrospective-study
#19
Naohiko Yoshizawa, Reiko Yamada, Takashi Sakuno, Hiroyuki Inoue, Hiroshi Miura, Toshifumi Takeuchi, Misaki Nakamura, Yasuhiko Hamada, Masaki Katsurahara, Kyosuke Tanaka, Noriyuki Horiki, Yoshiyuki Takei
We compared the sample volume of endoscopic ultrasound-guided fine-needle aspiration and biopsy (EUS-FNAB) specimens obtained by 22-gauge (22G) and 25-gauge (25G) needles, and the accuracy rate.This was a retrospective study in a single tertiary referral center. We investigated 153 patients with pancreatic ductal adenocarcinoma (PDAC) who underwent diagnostic EUS-FNAB before neoadjuvant gemcitabine-based chemoradiotherapy between October 2006 and November 2015. We performed immunohistochemical (IHC) analysis of human equilibrative nucleoside transporter 1 using the remnant cell blocks following pathological PDAC diagnosis...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29899332/tuneable-near-white-emissive-two-dimensional-covalent-organic-frameworks
#20
Xing Li, Qiang Gao, Juefan Wang, Yifeng Chen, Zhi-Hui Chen, Hai-Sen Xu, Wei Tang, Kai Leng, Guo-Hong Ning, Jishan Wu, Qing-Hua Xu, Su Ying Quek, Yixin Lu, Kian Ping Loh
Most two-dimensional (2D) covalent organic frameworks (COFs) are non-fluorescent in the solid state even when they are constructed from emissive building blocks. The fluorescence quenching is usually attributed to non-irradiative rotation-related or π-π stacking-caused thermal energy dissipation process. Currently there is a lack of guiding principle on how to design fluorescent, solid-state material made of COF. Herein, we demonstrate that the eclipsed stacking structure of 2D COFs can be used to turn on, and tune, the solid-state photoluminescence from non-emissive building blocks by the restriction of intramolecular bond rotation via intralayer and interlayer hydrogen bonds among highly organized layers in the eclipse-stacked COFs...
June 13, 2018: Nature Communications
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