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Acetate dialysis

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https://www.readbyqxmd.com/read/27900961/efficacy-and-safety-of-calcium-acetate-magnesium-carbonate-in-the-treatment-of-hyperphosphatemia-in-dialysis-patients
#1
Imed Helal, Hanene Elkateb, Hafedh Hedri, Malika Hajri, Fethi Ben Hamida
A phosphate binder combining calcium and magnesium offers an interesting therapeutic option to control hyperphosphatemia in dialysis patients. We investigated the effectiveness and tolerance of calcium acetate-magnesium carbonate (Ca-Mg). This is a 16-week prospective study including 16 dialysis patients. After an initial two-week washout period, serum phosphorus (sPho) ≥1.8 mmol/L, serum calcium (sCa) ≤2.6 mmol/L, and serum magnesium ≤1.5 mmol/L were the main inclusion criteria. The initial dose of Ca-Mg depended on sPho level and was titrated for every two weeks to have a sPho ≤ 1...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27878114/efficacy-of-biofilm-removal-from-hemodialysis-piping
#2
Yutaka Isakozawa, Heihachi Migita, Shingo Takesawa
BACKGROUND: Central dialysate fluid delivery systems (CDDS) are used by dialysis centers in Japan, and although these systems are effective at delivering dialysate, they have a complex piping network with numerous sites where contamination can develop. In Japan, cleaning disinfectants have been clinically evaluated based on endotoxin levels and bacterial counts, but there have been no published studies evaluating the biofilm removal efficacy of these agents at the electron microscope level...
September 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27859427/citrate-buffered-dialysis-solution-citrasate-allows-avoidance-of-anticoagulation-during-intermittent-hemodiafiltration-at-the-cost-of-decreased-performance-and-systemic-biocompatibility
#3
Pavlina Richtrova, Jan Mares, Lukas Kielberger, Ladislav Trefil, Jaromir Eiselt, Tomas Reischig
Reportedly, citrate-based dialysis solution enables heparin dose tapering or even complete exclusion, particularly in postdilution hemodiafiltration (HDF). The aim of the study was to verify this strategy in predilution setting and to assess its short-term safety, efficacy, and biocompatibility. Ten regular hemodialysis patients were assigned to predilution HDF on acetate- and citrate-based dialysis solutions (0.8 mmol/l trisodium citrate) at random order. Acetate HDF was performed using routine dose of heparin while citrate HDF was heparin free...
November 10, 2016: Artificial Organs
https://www.readbyqxmd.com/read/27615161/adherence-rates-to-ferric-citrate-as-compared-to-active-control-in-patients-with-end-stage-kidney-disease-on-dialysis
#4
Diana Jalal, Molly McFadden, Jamie P Dwyer, Kausik Umanath, Erwin Aguilar, Yoram Yagil, Barbara Greco, Mohammed Sika, Julia B Lewis, Tom Greene, Simin Goral
Introduction Oral phosphate binders are the main stay of treatment of hyperphosphatemia. Adherence rates to ferric citrate, a recently approved phosphate binder, are unknown. Methods We conducted a post-hoc analysis to evaluate whether adherence rates were different for ferric citrate vs. active control in 412 subjects with end stage kidney disease (ESKD) who were randomized to ferric citrate vs. active control (sevelamer carbonate and/or calcium acetate). Adherence was defined as percent of actual number of pills taken to total number of pills prescribed...
September 12, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27571344/simple-means-for-fractionating-protein-based-on-isoelectric-point-without-ampholyte
#5
Huang Chen, Zaifang Zhu, Haiqing Yu, Joann Juan Lu, Shaorong Liu
In this paper, we develop a simple electrokinetic means for fractionating protein samples according to their pI values without using ampholytes. The method uses inexpensive equipment, and its consumables are primarily ammonium acetate buffers. A key component of its apparatus is a dialysis membrane interface that eliminates electrolysis-caused protein oxidation/reduction and constrains proteins in the desired places. We demonstrate its feasibility for fractionating standard proteins and real-world samples. With the elimination of ampholytes, we can analyze the fractionated proteins directly by a matrix assisted laser desorption/ionization time-of-flight mass spectrometer...
September 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27516141/evidence-based-criteria-for-the-choice-and-the-clinical-use-of-the-most-appropriate-lock-solutions-for-central-venous-catheters-excluding-dialysis-catheters-a-gavecelt-consensus
#6
Mauro Pittiruti, Sergio Bertoglio, Giancarlo Scoppettuolo, Roberto Biffi, Massimo Lamperti, Alberto Dal Molin, Nicola Panocchia, Nicola Petrosillo, Mario Venditti, Carla Rigo, Enrico DeLutio
BACKGROUND: The most appropriate lock solution for central venous access devices is still to be defined. GAVeCeLT - the Italian group for venous access devices - has developed a consensus on the evidence-based criteria for the choice and the clinical use of the most appropriate lock solution for central venous catheters (excluding dialysis catheters). METHOD: After the constitution of a panel of experts, a systematic collection and review of the literature has been performed, focusing on clinical studies dealing with lock solutions used for prevention of occlusion (heparin, citrate, urokinase, recombinant tissue plasminogen activator [r-TPA], normal saline) or for prevention of infection (citrate, ethanol, taurolidine, ethylene-diamine-tetra-acetic acid [EDTA], vancomycin, linezolid and other antibiotics), in both adults and in pediatric patients...
August 1, 2016: Journal of Vascular Access
https://www.readbyqxmd.com/read/27481742/acetate-buffered-crystalloid-fluids-current-knowledge-a-systematic-review
#7
REVIEW
Carmen A Pfortmueller, Edith Fleischmann
INTRODUCTION: The concept of fluid resuscitation with balanced solutions containing acetate is relatively new. The knowledge about acetate mostly originates from nephrological research, as acetate was primarily used as a dialysis buffer where much higher doses of acetate are infused. The aim of this review is to give an overview of the advantages and disadvantages of an acetate-buffered crystalloid fluid when compared with other crystalloid infusates. METHODS: We report trials with the primary object of comparing an acetate-buffered infusion solute to another crystalloid infusate...
October 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27471673/preparation-and-evaluation-of-a-phospholipid-based-injectable-gel-for-the-long-term-delivery-of-leuprolide-acetaterrh
#8
Danhong Long, Tao Gong, Zhirong Zhang, Rui Ding, Yao Fu
A phospholipid-based injectable gel was developed for the sustained delivery of leuprolide acetate (LA). The gel system was prepared using biocompatible materials (SPME), including soya phosphatidyl choline (SPC), medium chain triglyceride (MCT) and ethanol. The system displayed a sol state with low viscosity in vitro and underwent in situ gelation in vivo after subcutaneous injection. An in vitro release study was performed using a dialysis setup with different release media containing different percentages of ethanol...
July 2016: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/27466292/biphasic-effects-of-copper-on-rat-learning-and-memory-in-the-morris-water-maze
#9
Yuan Zhang, Wulin Lu, Ming Han, Hui Li, Hongjun Luo, Weiqiu Li, Wenhong Luo, Zhexuan Lin
Dysregulation of copper (Cu) metabolism interrupts neuron function, and subsequently results in neuron degeneration, necrosis, and gliocyte hyperplasia. To further explore the effects of hippocampal Cu concentration on learning and memory, Sprague-Dawley (SD) rats were given once-daily intraperitoneal injections of Copper(II) acetate (Cu(OAc)2) at doses of 0.2, 2, or 20mg/Kg over 5 days. Ultrasonic oscillation dialysis was used to determine the free Cu by graphite furnace atomic absorption spectrometry (GFAAS)...
July 2016: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/27440751/use-of-dialysis-and-liquid-liquid-extraction-for-the-determination-of-propionic-acid-by-gas-chromatography
#10
Takahiro Sasaki, Shoichi Tahara, Yukiko Yamajima, Hiroyuki Miyakawa, Yoko Uematsu, Kimio Monma
A simple and efficient method for the determination of propionic acid (PA) in foods was developed. The sample was cleaned up by dialysis, and PA in the resulting solution was extracted into ethyl acetate for GC analysis. Sodium sulfate was used as a salting-out agent in the extraction process, and GC-FID and GC-MS were successfully applied to the determination and confirmation of PA, respectively. The recoveries were in the range of 98.9-104.4% at the addition level of 0.2 g/kg from 6 foods, bread, cake, cheese, worcester sauce, vinegar-pickles and yogurt...
2016: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/27405175/-preparation-and-evaluation-of-intra-articular-injectable-sinomenine-hydrochloride-loaded-in-situ-liquid-crystals
#11
Yu-lin Chen, Shuang-ying Gui, Xin Liang, Sheng-mei Wang, Xiao-jing Jiang
Phytantriol (PT), ethanol (ET) and water were used to prepare in situ cubic liquid crystal (ISV2). The pseudo-ternary phase diagram of PT-ET-water was constructed and isotropic solution formulations were chosen for further optimization. The physicochemical properties of isotropic solution formulations were evaluated to optimize the composition of ISV2. In situ hexagonal liquid crystals (ISH2) were prepared based on the composition of ISV2 with the addition of vitamin E acetate (VitEA) and the amount of VitEA was optimized by in vitro release behavior...
January 2016: Yao Xue Xue Bao, Acta Pharmaceutica Sinica
https://www.readbyqxmd.com/read/27164837/mechanical-properties-cytocompatibility-and-manufacturability-of-chitosan-pegda-hybrid-gel-scaffolds-by-stereolithography
#12
Viola B Morris, Siddharth Nimbalkar, Mousa Younesi, Phillip McClellan, Ozan Akkus
Extracellular matrix mimetic hydrogels which hybridize synthetic and natural polymers offer molecularly-tailored, bioactive properties and tunable mechanical strength. In addition, 3D bioprinting by stereolithography allows fabrication of internal pores and defined macroscopic shapes. In this study, we formulated a hybrid biocompatible resin using natural and synthetic polymers (chitosan and polyethylene glycol diacrylate (PEGDA), respectively) by controlling molecular weight of chitosan, feed-ratios, and photo-initiator concentration...
May 10, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27129599/lc-ms-ms-method-for-simultaneous-determination-of-serum-p-cresyl-sulfate-and-indoxyl-sulfate-in-patients-undergoing-peritoneal-dialysis
#13
Chang Shu, Xujiao Chen, Tianyi Xia, Feng Zhang, Shouhong Gao, Wansheng Chen
P-cresol sulphate (pCS) and indoxyl sulfate (IS) are protein-bound uremic toxins (UTs) that accumulate in patients with chronic kidney disease (CKD). They are closely associated with the mortality rate of CKD and morbidity of cardiovascular disease. In the present study, we established a rapid method for determination of pCS and IS by HPLC-MS/MS in serum samples from 205 CKD patients undergoing peritoneal dialysis (PD). In brief, serum was extracted by acetonitrile and spiked with hydrochlorothiazide. The prepared sample was eluted through HPLC column (Agilent Zorbax SB-C18 , 3...
April 30, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27105041/collagen-degradation-and-preservation-of-mmp-8-activity-in-human-dentine-matrix-after-demineralization
#14
Anders Hedenbjörk-Lager, Kristina Hamberg, Virve Pääkkönen, Leo Tjäderhane, Dan Ericson
OBJECTIVE: Dental caries is a process driven by acids produced by oral microorganisms followed by degradation of the dentine collagen matrix by proteolytic enzymes. Matrix metalloproteinases (MMPs) have been suggested to contribute to caries by degrading collagen. The aim of this study was to develop a method for generating demineralized dentine matrix substrate (DDM) maintaining MMP-8 bioactivity and no interference with later assays. Such a substrate would allow study of the effects of various treatments on MMP-8 activity and collagen degradation in demineralized dentine...
August 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27099775/regional-citrate-anticoagulation-in-hemodialysis-an-observational-study-of-safety-efficacy-and-effect-on-calcium-balance-during-routine-care
#15
Richard F Singer, Oliver Williams, Chari Mercado, Bonny Chen, Girish Talaulikar, Giles Walters, Darren M Roberts
BACKGROUND: Regional citrate hemodialysis anticoagulation is used when heparin is contraindicated, but most protocols require large infusions of calcium and frequent intradialytic plasma ionized calcium measurements. OBJECTIVES: The objective of this study was to determine the safety, efficacy, and effect on calcium balance of regional citrate anticoagulation using sparse plasma ionized calcium sampling. DESIGN: The design of this study was observational...
2016: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/27082064/we-lower-blood-flow-for-intradialytic-hypotension
#16
Richard A Sherman
Whether hemodialysis is performed through a fistula, graft, or a dialysis catheter, it is a common practice to lower the dialyzer blood flow in patients who develop intradialytic hypotension. Lowering dialyzer blood flow is assumed to reduce AV access blood flow and thus increase peripheral vascular resistance tending to raise blood pressure. As a general rule, however, such a reduction in dialyzer blood flow does not lower access flow; only in the case of an intra-access stenosis could this be the case. Reducing access blood flow (in both catheter and AV accesses) did ameliorate a number of potential contributors to intradialytic hypotension when older dialysis technologies were routinely used...
July 2016: Seminars in Dialysis
https://www.readbyqxmd.com/read/27038806/successful-conversion-from-parenteral-paricalcitol-to-pulse-oral-calcitriol-for-the-management-of-secondary-hyperparathyroidism-in-hemodialysis-patients
#17
Jennifer Kumar, Ngoc-Tram Gia Tran, John Schomberg, Elani Streja, Kamyar Kalantar-Zadeh, Madeleine Pahl
OBJECTIVE: The management of hyperparathyroidism in hemodialysis patients involves the administration of phosphate binders, vitamin D receptor activators, and calcimimetics. Intravenous paricalcitol has been preferred over oral calcitriol as it may cause less hypercalcemia and hyperphosphatemia. However, there is little data looking at the efficacy and tolerability of oral calcitriol in the calcimimetic era particularly in a real practice-based experience. The University of California, Irvine free-standing dialysis center converted from routine intravenous paricalcitol to oral calcitriol due to pharmacy purchasing preferences...
July 2016: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/27001371/sclerostin-levels-in-uremic-patients-a-link-between-bone-and-vascular-disease
#18
Annamaria Bruzzese, Antonio Lacquaniti, Valeria Cernaro, Carlo Alberto Ricciardi, Saverio Loddo, Adolfo Romeo, Gaetano Montalto, Giuseppe Costantino, Francesco Torre, Giuseppina Pettinato, Ignazio Salamone, Carmela Aloisi, Domenico Santoro, Michele Buemi
Sclerostin is a marker of low-turnover bone disease in end stage renal disease patients. The aim of this study was to evaluate serum sclerostin in uremic patients, analyzing its behavior during a single hemodialysis session. Twenty-one adult patients on intermittent hemodialysis treatment were enrolled. Acetate Free Bio-filtration (AFB) was the technique employed. Uremic patients were characterized by higher levels of serum sclerostin when compared with values observed in healthy subjects. Sclerostin assessed in pre-dialysis samples was 1...
June 2016: Renal Failure
https://www.readbyqxmd.com/read/26950120/biomimetic-membranes-for-multi-redox-center-proteins
#19
REVIEW
Renate L C Naumann, Andreas F Geiss, Christoph Steininger, Wolfgang Knoll
His-tag technology was applied for biosensing purposes involving multi-redox center proteins (MRPs). An overview is presented on various surfaces ranging from flat to spherical and modified with linker molecules with nitrile-tri-acetic acid (NTA) terminal groups to bind his-tagged proteins in a strict orientation. The bound proteins are submitted to in situ dialysis in the presence of lipid micelles to form a so-called protein-tethered bilayer lipid membrane (ptBLM). MRPs, such as the cytochrome c oxidase (CcO) from R...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26893577/phosphate-binders-for-the-treatment-of-chronic-kidney-disease-role-of-iron-oxyhydroxide
#20
REVIEW
Valeria Cernaro, Domenico Santoro, Antonio Lacquaniti, Giuseppe Costantino, Luca Visconti, Antoine Buemi, Michele Buemi
Chronic kidney disease-mineral bone disorder is frequent in patients with renal failure. It is characterized by abnormalities in mineral and bone metabolism with resulting hyperphosphatemia, low serum vitamin D, secondary hyperparathyroidism, altered bone morphology and strength, higher risk of bone fractures, and development of vascular or other soft tissue calcifications. Besides the recommendation to reduce phosphorus dietary intake, many drugs are currently available for the treatment of calcium/phosphate imbalance...
2016: International Journal of Nephrology and Renovascular Disease
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