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https://www.readbyqxmd.com/read/28941917/national-trends-in-the-management-of-primary-vesicoureteral-reflux-in-children
#1
Michael Garcia-Roig, Curtis Tavers, Courtney E McCracken, Andrew J Kirsch
OBJECTIVE: In September 2011, the American Academy of Pediatrics(AAP) released updated guidelines for workup of children 2-24 months old with a febrile urinary tract infection(UTI). We aimed to document the guideline's impact on diagnosis and surgical management of VUR at US children's hospitals. We hypothesize that VCUG studies and VUR treatment rate decreased concurrent with national guideline release. METHODS: The Pediatric Health Information System(PHIS) was queried for children(<18 years) with primary VUR, and their anti-reflux surgical history, from January 2004-June 2015...
September 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28939004/the-phase-3-cou-aa-302-study-of-abiraterone-acetate-plus-prednisone-in-men-with-chemotherapy-na%C3%A3-ve-metastatic-castration-resistant-prostate-cancer-stratified-analysis-based-on-pain-prostate-specific-antigen-and-gleason-score
#2
Kurt Miller, Joan Carles, Jürgen E Gschwend, Hendrik Van Poppel, Joris Diels, Sabine D Brookman-May
BACKGROUND: In the COU-AA-302 study (NCT00887198), abiraterone acetate plus prednisone (AAP) significantly improved outcomes in patients with metastatic castration-resistant prostate cancer (mCRPC) versus prednisone alone. Baseline clinical parameters predicting that treatment response could help inform clinical decisions were explored. OBJECTIVE: To identify patients who derive the greatest clinical benefit from AAP treatment. DESIGN, SETTING, AND PARTICIPANTS: A total of 1088 mCRPC patients treated with either AAP or prednisone in the first-line setting in COU-AA-302 were included in this post hoc analysis...
September 19, 2017: European Urology
https://www.readbyqxmd.com/read/28936817/-assessment-of-adolescent-attachment-styles-via-narrative-responses-to-the-thematic-stimulus
#3
Zeynep Tüzün, Gonca Soygüt
OBJECTIVE: The aim of this research is to develop a new protocol with a projective test and qualitative assessment approach for investigating mental representations effective for the formation of attachment styles and to examine its psychometric properties. METHOD: Thirty-three adolescents who admitted to the Division of Adolescent Medicine of Hacettepe University participated to the study. The Adolescent Attachment Protocol (AAP) and Relationship Styles Questionnaire (RSQ) were used...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28933929/diagnostic-accuracy-of-two-food-insecurity-screeners-recommended-for-use-in-health-care-settings
#4
Jennifer A Makelarski, Emily Abramsohn, Jasmine H Benjamin, Senxi Du, Stacy Tessler Lindau
OBJECTIVES: To test the diagnostic accuracy of the American Academy of Pediatrics (AAP) recommended food insecurity screener. METHODS: We conducted prospective diagnostic accuracy studies between July and November 2016 in Chicago, Illinois. We recruited convenience samples of adults from adult and pediatric emergency departments (12-month recall study: n = 188; 30-day recall study: n = 154). A self-administered survey included the 6-item Household Food Security Screen (gold standard), the validated 2-item Hunger Vital Sign (HVS; often, sometimes, never response categories), and the 2-item AAP tool (yes-or-no response categories)...
September 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28933570/developing-pictorial-asthma-action-plans-to-promote-self-management-and-health-in-rural-youth-with-asthma-a-qualitative-study
#5
Christina L Duncan, Heather A Walker, Laurel Brabson, Desireé N Williford, Lisa Hynes, Mary Beth Hogan
OBJECTIVE: Asthma action plans (AAPs) provide asthma management instructions to families; however, AAPs typically are written at a 7(th)-9(th) grade reading level, making them less useful in lower literacy families. There is a need to develop simpler AAP formats and content to optimize their utility across all families, including those who are rural and may be at risk for literacy concerns. Because using pictures can simplify and enhance health education, our study aim was to develop a pictorial AAP through a series of focus groups with key stakeholders - youth with asthma, caregivers, and physicians...
September 21, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28924062/national-trends-in-pediatricians-practices-and-attitudes-about-breastfeeding-1995-to-2014
#6
Lori Feldman-Winter, Kinga Szucs, Aubri Milano, Elizabeth Gottschlich, Blake Sisk, Richard J Schanler
BACKGROUND AND OBJECTIVES: The American Academy of Pediatrics (AAP) has affirmed breastfeeding as the preferred method of infant feeding; however, there has been little systematic examination of how pediatricians' recommendations, affiliated hospitals' policies, counseling practices, and attitudes toward breastfeeding have shifted over the past 2 decades. These trends were examined from 1995 to 2014. METHODS: Data are from the Periodic Survey (PS) of Fellows, a nationally representative survey of AAP members...
September 18, 2017: Pediatrics
https://www.readbyqxmd.com/read/28891037/analytical-insight-into-degradation-processes-of-aminopolyphosphonates-as-potential-factors-that-induce-cyanobacterial-blooms
#7
Damian Drzyzga, Jacek Lipok
Aminopolyphosphonates (AAPs) are commonly used industrial complexones of metal ions, which upon the action of biotic and abiotic factors undergo a breakdown and release their substructures. Despite the low toxicity of AAPs towards vertebrates, products of their transformations, especially those that contain phosphorus and nitrogen, can affect algal communities. To verify whether such chemical entities are present in water ecosystems, much effort has been made in developing fast, inexpensive, and reliable methods for analyzing phosphonates...
September 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28888517/beliefs-regarding-asthma-management-relating-to-asthma-action-plans-aaps-of-african-american-caregivers-residing-in-newark-new-jersey-public-housing-communities
#8
Frank Wagner, Lorraine Steefel
PURPOSE: The purpose of this study was to explore the beliefs regarding asthma management and Asthma Action Plans (AAPs) of African American caregivers residing in three New Jersey public housing communities in Newark, New Jersey. DESIGN: A qualitative methods design was accomplished using semi-structured interviews with a purposive sample of nine African American caregivers of children with asthma. Information was coded using N'VIVO™; the textual analysis combined codes into categories, which were then assembled into themes...
September 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28883496/overexpression-of-insig-2-inhibits-atypical-antipsychotic-induced-adipogenic-differentiation-and-lipid-biosynthesis-in-adipose-derived-stem-cells
#9
Chien-Chih Chen, Li-Wen Hsu, Kuang-Tzu Huang, Shigeru Goto, Chao-Long Chen, Toshiaki Nakano
Atypical antipsychotics (AAPs) are considered to possess superior efficacy for treating both the positive and negative symptoms of schizophrenia; however, AAP use often causes excessive weight gain and metabolic abnormalities. Recently, several reports have demonstrated that AAPs activate sterol regulatory element-binding protein (SREBP). SREBP, SREBP cleavage-activating protein (SCAP) and insulin-induced gene (Insig) regulate downstream cholesterol and fatty acid biosynthesis. In this study, we explored the effects of clozapine, olanzapine and risperidone on SREBP signaling and downstream lipid biosynthesis genes in the early events of adipogenic differentiation in adipose-derived stem cells (ASCs)...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28868896/stock-photographs-do-not-comply-with-infant-safe-sleep-guidelines
#10
Michael H Goodstein, Elena Lagon, Theodore Bell, Brandi L Joyner, Rachel Y Moon
We evaluated images in popular stock photography websites for adherence with American Academy of Pediatrics (AAP) guidelines for safe infant sleep practices. Three top stock photo websites were used to collect photographs generated from key phrases. All images depicting an infant sleep environment were analyzed for consistency with AAP guidelines. Descriptive statistics, chi-square and z test of proportions, were conducted. A total of 1233 of 1947 stock photographs showed sleeping infants on a flat surface...
September 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28866466/impact-of-clinical-guidelines-on-voiding-cystourethrogram-utilization-and-vesicoureteral-reflux-incidence
#11
Ted Lee, Chandy Ellimoottil, Kathryn A Marchetti, Tanima Banerjee, Vesna Ivančić, Kate H Kraft, David A Bloom, John M Park, Julian Wan
BACKGROUND: To prevent overdiagnosis and overtreatment of vesicoureteral reflux, the 2007 British National Institution of Clinical Excellence (NICE) and 2011 American Academy of Pediatrics (AAP) guidelines both recommended against routine voiding cystourethrogram in children presenting with first febrile urinary tract infections. The impact of these guidelines on clinical practice is unknown. METHODS: Using an administrative claims database (Cliniformatics(TM) Data Mart), children with voiding cystourethrogram or diagnosis of vesicoureteral reflux between 2001 and 2015 were identified...
August 30, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28864710/principles-of-child-health-care-financing
#12
Mark L Hudak, Mark E Helm, Patience H White
After passage of the Patient Protection and Affordable Care Act, more children and young adults have become insured and have benefited from health care coverage than at any time since the creation of the Medicaid program in 1965. From 2009 to 2015, the uninsurance rate for children younger than 19 years fell from 9.7% to 5.3%, whereas the uninsurance rate for young adults 19 to 25 years of age declined from 31.7% to 14.5%. Nonetheless, much work remains to be done. The American Academy of Pediatrics (AAP) believes that the United States can and should ensure that all children, adolescents, and young adults from birth through the age of 26 years who reside within its borders have affordable access to high-quality and comprehensive health care, regardless of their or their families' incomes...
September 2017: Pediatrics
https://www.readbyqxmd.com/read/28860773/can-melatonin-prevent-or-improve-metabolic-side-effects-during-antipsychotic-treatments
#13
Maria-Cristina Porfirio, Juliana Paula Gomes de Almeida, Maddalena Stornelli, Silvia Giovinazzo, Diane Purper-Ouakil, Gabriele Masi
In the last two decades, second-generation antipsychotics (SGAs) were more frequently used than typical antipsychotics for treating both psychotic and nonpsychotic psychiatric disorders in both children and adolescents, because of their lower risk of adverse neurological effects, that is, extrapyramidal symptoms. Recent studies have pointed out their effect on weight gain and increased visceral adiposity as they induce metabolic syndrome. Patients receiving SGAs often need to be treated with other substances to counteract metabolic side effects...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28860136/lewis-cw-jacob-ls-lehmann-cu-aap-section-on-oral-health-the-primary-care-pediatrician-and-the-care-of-children-with-cleft-lip-and-or-cleft-palate-pediatrics-2017-139-5-e20170628
#14
https://www.readbyqxmd.com/read/28856486/the-automated-assessment-of-postural-stability-balance-detection-algorithm
#15
Alessandro Napoli, Stephen M Glass, Carole Tucker, Iyad Obeid
Impaired balance is a common indicator of mild traumatic brain injury, concussion and musculoskeletal injury. Given the clinical relevance of such injuries, especially in military settings, it is paramount to develop more accurate and reliable on-field evaluation tools. This work presents the design and implementation of the automated assessment of postural stability (AAPS) system, for on-field evaluations following concussion. The AAPS is a computer system, based on inexpensive off-the-shelf components and custom software, that aims to automatically and reliably evaluate balance deficits, by replicating a known on-field clinical test, namely, the Balance Error Scoring System (BESS)...
August 30, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28841573/pediatric-providers-attitudes-and-practices-regarding-concussion-diagnosis-and-management
#16
Khalida Itriyeva, Ronald Feinstein, Linda Carmine
Background Concussions, a form of mild traumatic brain injury, are a current "hot topic" in sports and medicine, with current research focusing on diagnosis, treatment, and the long-term effects of repeated concussions on development of chronic traumatic encephalopathy. Concussions represent 8.9% of all high school athletic injuries, and pediatricians see many of these patients in their practices, however evolving guidelines and recommendations have resulted in varying practices among providers. Objective To assess how local pediatricians in New York Chapter 2 of the American Academy of Pediatrics (AAP) diagnose and treat concussion patients, and to evaluate the need for continuing education in this area...
August 25, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28835125/small-but-increasingly-mighty-latest-advances-in-aav-vector-research-design-and-evolution
#17
Dirk Grimm, Hildegard Büning
Recombinant gene delivery vectors derived from naturally occurring or genetically engineered Adeno-associated viruses (AAV) have taken center stage in human gene therapy, fueled by rapidly accumulating and highly encouraging clinical data. Nonetheless, it has also become evident that the current generation of AAV vectors will require improvements in transduction potency, antibody evasion and cell specificity, to realize their full potential and to widen applicability in larger patient cohorts. Fortunately, in the recent past, the field has seen a flurry of exciting new developments that enhance our understanding of AAV vector biology including virus-host interactions and/or that expand our arsenal of technologies for AAV capsid design and evolution...
August 23, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28832182/new-universal-nomenclature-in-auriculotherapy
#18
David Alimi, Jacques E Chelly
OBJECTIVES: To propose at the auriculotherapists a New Universal Nomenclature of Auriculotherapy, able to receive any mapping whatsoever. DESIGN: We built this proposition by using electronic database search to find the different formulations of Auricular Acupuncture Points (AAPs), by studying neuroradiology methods describing reliable and reproducible marks able to adapt to all brain morphologies, by studying the analysis of brain dissections, showed us the internal organization of the brain; and after having proved the neurophysiological correlations between auricular displays and their brain correspondences...
August 23, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28829186/outsourcing-in-bioanalysis-a-cro-perspective
#19
Stephen Lowes
Steve Lowes from Q(2) Solutions speaks to Sankeetha Nadarajah, Managing Commissioning Editor: about outsourcing strategy implementation. Steve started his industrial career at VG Biotech in the UK that became the LC-MS instrument entity of Waters Corporation. Since joining the CRO group that became Advion and then Q(2) Solutions, his career has focused on regulated bioanalysis with particular emphasis on LC-MS. He is a founding member of the Global Bioanalysis Consortium and a past-chair of the AAPS Bioanalytical Focus Group...
August 2017: Bioanalysis
https://www.readbyqxmd.com/read/28827847/prevalence-of-asymptomatic-apical-periodontitis-and-its-association-with-coronary-artery-disease-in-a-brazilian-subpopulation
#20
Bruna Paloma de Oliveira, Andréa Cruz Câmara, Carlos Menezes Aguiar
OBJECTIVE: The aim of the present study was to determine the prevalence of asymptomatic apical periodontitis (AAP) and its association with coronary artery disease (CAD) in a Brazilian subpopulation, and to examine the correlation of AAP with gender, age and most frequently affected dental elements. METHODS: The data were collected from medical records of the patients (n = 1346) treated at the Specialization in Endodontics Clinic of the Federal University of Pernambuco in the period between 2003 and 2010...
June 2017: Acta Stomatologica Croatica
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