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https://www.readbyqxmd.com/read/28430936/preliminary-evaluation-of-the-niaaa-aap-brief-alcohol-use-screener
#1
Alan Meca, Jonathan G Tubman, Timothy Regan, Diane D Zheng, Rhoda Moise, Tae Kyoung Lee, Mary H Soares, Maria R Velazquez, Andrew Egbert, Seth J Schwartz
Aims: To assess the concurrent validity of the two-item NIAAA/American Academy of Pediatrics Brief Alcohol Use Screener, a developmentally sensitive assessment instrument, in a school-based sample of adolescents. Method: The sample consisted of 756 adolescents (53% girls; Mage = 13.7 years; SD = 1.6 years) in the 6th (n = 192), 8th (n = 283), and the 10th (n = 281) grades from Miami-Dade County, FL and Prince George's County, MD. Adolescents completed the NIAAA/AAP Brief Alcohol Use Screener, which consists of two items asking about adolescents' alcohol use and about peers' alcohol use during the last year...
May 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28428097/care-coordination-and-comprehensive-electronic-health-records-are-associated-with-increased-transition-planning-activities
#2
Niraj Sharma, Kitty O'Hare, Karen G O'Connor, Umbereen Nehal, Megumi J Okumura
OBJECTIVE: Youth with Special Health Care Needs (YSHCN) require assistance from their pediatricians to transition to adult care. There is little data on what transition resources pediatricians have. This paper studies if care coordination and/or comprehensive electronic health record (CEHR) implementation are associated with improved transition processes. METHODS: Using AAP Periodic Survey #79, we report whether practices generated written transition plans, assisted in finding adult providers, and discussed confidentiality issues...
April 18, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28419179/the-intensity-of-brief-interventions-in-patients-with-acute-alcoholic-pancreatitis-should-be-increased-especially-in-young-patients-with-heavy-alcohol-consumption
#3
Jussi Nikkola, Johanna Laukkarinen, Heini Huhtala, Juhani Sand
Aims: After the first acute alcoholic pancreatitis (AAP), active repeated brief interventions (BIs) have been shown to protect against recurrent acute pancreatitis (RAP). However, in daily hospital practice the treatment of alcohol problems varies. Our aim was to study BIs performed in the clinic during AAP and whether this prevents from future RAP episodes. Methods: Data on all patients discharged between 10/2010 and 10/2012 with acute pancreatitis as the primary diagnosis were obtained from the hospital database...
April 13, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28419115/properties-of-the-cuticular-proteins-of-anopheles-gambiae-as-revealed-by-serial-extraction-of-adults
#4
Yihong Zhou, Majors J Badgett, Lynne Billard, John Hunter Bowen, Ron Orlando, Judith H Willis
How cuticular proteins (CPs) interact with chitin and with each other in the cuticle remains unresolved. We employed LC-MS/MS to identify CPs from 5-6 day-old adults of Anopheles gambiae released after serial extraction with PBS, EDTA, 2-8M urea, and SDS as well as those that remained unextracted. Results were compared to published data on time of transcript abundance, localization of proteins within structures and within the cuticle, as well as properties of individual proteins, length, pI, percent histidine, tyrosine, glutamine, and number of AAP[A/V/L] repeats...
2017: PloS One
https://www.readbyqxmd.com/read/28400304/parent-preferences-and-perceptions-of-mls-and-teaspoons-role-of-health-literacy-and-experience
#5
Alejandro Torres, Ruth M Parker, Lee M Sanders, Michael S Wolf, Stacy Bailey, Deesha A Patel, Jessica J Jimenez, Kwang-Youn A Kim, Benard P Dreyer, Alan Mendelsohn, H Shonna Yin
BACKGROUND AND OBJECTIVES: A recent AAP policy statement recommends mL-exclusive dosing for pediatric liquid medications. Little is known about parent preferences regarding units, perceptions about moving to mL-only, and the role of health literacy and prior mL-dosing experience. METHODS: Cross-sectional analysis of data collected as part of a randomized controlled study in 3 urban pediatric clinics (SAFE-Rx for Kids study). English/Spanish-speaking parents (n=493) of children <8 years were randomized to 1 of 4 study arms and given labels/dosing tools which varied in label instruction format (text+pictogram, text-only) and units (mL-only, mL/tsp)...
April 8, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28392175/structural-basis-of-mycobacterium-tuberculosis-transcription-and-transcription-inhibition
#6
Wei Lin, Soma Mandal, David Degen, Yu Liu, Yon W Ebright, Shengjian Li, Yu Feng, Yu Zhang, Sukhendu Mandal, Yi Jiang, Shuang Liu, Matthew Gigliotti, Meliza Talaue, Nancy Connell, Kalyan Das, Eddy Arnold, Richard H Ebright
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, which kills 1.8 million annually. Mtb RNA polymerase (RNAP) is the target of the first-line antituberculosis drug rifampin (Rif). We report crystal structures of Mtb RNAP, alone and in complex with Rif, at 3.8-4.4 Å resolution. The results identify an Mtb-specific structural module of Mtb RNAP and establish that Rif functions by a steric-occlusion mechanism that prevents extension of RNA. We also report non-Rif-related compounds-Nα-aroyl-N-aryl-phenylalaninamides (AAPs)-that potently and selectively inhibit Mtb RNAP and Mtb growth, and we report crystal structures of Mtb RNAP in complex with AAPs...
April 20, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28387637/independent-validation-of-the-adjusted-gapss-role-of-thrombotic-risk-assessment-in-the-real-life-setting
#7
N Fernandez Mosteirin, L Saez Comet, C Salvador Osuna, J M Calvo Villas, J Velilla Marco
Objective The objective of this report is to independently validate the adjusted Global Antiphospholipid Syndrome Score (aGAPSS) to predict thrombosis in a cohort of patients with APS and/or autoimmune disease. Methods This retrospective cohort study included 319 consecutive patients with APS and/or autoimmune disease. Data on clinical manifestations, conventional cardiovascular risk factors and aPL profile were collected. The aGAPSS was calculated for each patient by adding together the points corresponding to the risk factors...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28386382/protective-effects-of-an-ethanol-extract-of-angelica-keiskei-against-acetaminophen-induced-hepatotoxicity-in-hepg2-and-heparg-cells
#8
Yoon-Hee Choi, Hyun Sook Lee, Cha-Kwon Chung, Eun Ji Kim, Il-Jun Kang
BACKGROUND/OBJECTIVE: Although Angelica keiskei (AK) has widely been utilized for the purpose of general health improvement among Asian, its functionality and mechanism of action. The aim of this study was to determine the protective effect of ethanol extract of AK (AK-Ex) on acute hepatotoxicity induced by acetaminophen (AAP) in HepG2 human hepatocellular liver carcinoma cells and HepaRG human hepatic progenitor cells. MATERIALS/METHODS: AK-Ex was prepared HepG2 and HepaRG cells were cultured with various concentrations and 30 mM AAP...
April 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28385683/the-multimodal-assessment-of-adult-attachment-security-developing-the-biometric-attachment-test
#9
Federico Parra, Raphaële Miljkovitch, Gwenaelle Persiaux, Michelle Morales, Stefan Scherer
BACKGROUND: Attachment theory has been proven essential for mental health, including psychopathology, development, and interpersonal relationships. Validated psychometric instruments to measure attachment abound but suffer from shortcomings common to traditional psychometrics. Recent developments in multimodal fusion and machine learning pave the way for new automated and objective psychometric instruments for adult attachment that combine psychophysiological, linguistic, and behavioral analyses in the assessment of the construct...
April 6, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28379719/a-simple-anthropometric-tool-for-the-assessment-of-pre-sarcopenia-in-postmenopausal-women
#10
M E Morosano, I M Menoyo, M F Tomat, A M Masoni, S M Pezzotto
OBJECTIVES: The purpose of this research was to explore the performance of anthropometric tools in the assessment of low muscle mass in a group of postmenopausal women. METHOD: Fifty consecutive ambulatory postmenopausal women were studied. A complete clinical examination and an anthropometric evaluation following a standardized procedure were performed. Three indicators were devised: upper limb adjusted perimeter (ULAP), lower limb adjusted perimeter (LLAP), and appendicular adjusted perimeter (AAP)...
April 5, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28375864/risk-factors-for-asparaginase-associated-pancreatitis-a-systematic-review
#11
Judy-April Oparaji, Fateema Rose, Debra Okafor, Amari Howard, Rose L Turner, Abrahim I Orabi, Craig Byersdorfer, Qi Mi, Kim Ritchey, Mark E Lowe, Sohail Z Husain
GOALS: To evaluate potential risk factors for the development of asparaginase-associated pancreatitis (AAP), we performed a systematic review of the current literature from January 1946 through May 2015. BACKGROUND: Asparaginase, a primary treatment for the most common childhood cancer, acute lymphoblastic leukemia (ALL), is a well-described cause of pancreatitis. Further, pancreatitis is among the most burdensome and common complications of asparaginase treatment and represents a major reason for early-drug termination and inferior outcomes...
April 3, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28372635/trends-in-the-prescribing-of-atypical-antipsychotics-in-elderly-patients-with-dementia-in-korea%C3%A2
#12
Namjoo Seo, Inmyung Song, Heyekyung Park, Dongmun Ha, Ju-Young Shin
OBJECTIVE: In 2005, the Food and Drug Administration warned that atypical antipsychotics (AAPs) increased mortality in elderly patients with dementia. We investigated AAP prescribing in elderly patients with dementia in the ambulatory setting in Korea and the factors affecting AAP prescribing in elderly patients with dementia. METHODS: Subjects ≥ 65 years of age with at least one diagnosis of dementia (ICD-10: F00-F03, G30, G31.8) from January 1 to December 31, 2013 were identified from a health insurance database...
April 4, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28371801/preliminary-evaluation-of-the-niaaa-aap-brief-alcohol-use-screener
#13
Alan Meca, Jonathan G Tubman, Timothy Regan, Diane D Zheng, Rhoda Moise, Tae Kyoung Lee, Mary H Soares, Maria R Velazquez, Andrew Egbert, Seth J Schwartz
No abstract text is available yet for this article.
March 29, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28371065/fixation-of-co2-using-the-ethylmalonyl-coa-pathway-in-the-photoheterotrophic-marine-bacterium-dinoroseobacter-shibae
#14
Nelli Bill, Jürgen Tomasch, Alexander Riemer, Katrin Müller, Sarah Kleist, Kerstin Schmidt-Hohagen, Irene Wagner-Döbler, Dietmar Schomburg
The ability of aerobic anoxygenic photoheterotrophs (AAPs) to gain additional energy from sunlight represents a competitive advantage, especially in conditions where light has easy access or under environmental conditions may change quickly, such as those in the world's oceans. However, the knowledge about the metabolic consequences of aerobic anoxygenic photosynthesis is very limited. Combining transcriptome and metabolome analyses, isotopic labeling techniques, measurements of growth, oxygen uptake rates, flow cytometry, and a number of other biochemical analytical techniques we obtained a comprehensive overview on the complex adaption of the marine bacterium Dinoroseobacter shibae DFL12(T) during transition from heterotrophy to photoheterotrophy (growth on succinate)...
April 3, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28365102/2016-section-on-surgery-annual-meeting-aap-national-conference-exhibition
#15
REVIEW
Edward P Tagge
No abstract text is available yet for this article.
March 18, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28364046/neonatal-hypoglycemia
#16
Alecia Thompson-Branch, Thomas Havranek
Lower blood glucose values are common in the healthy neonate immediately after birth as compared to older infants, children, and adults. These transiently lower glucose values improve and reach normal ranges within hours after birth. Such transitional hypoglycemia is common in the healthy newborn. A minority of neonates experience a more prolonged and severe hypoglycemia, usually associated with specific risk factors and possibly a congenital hypoglycemia syndrome. Despite the lack of a specific blood glucose value that defines hypoglycemia, concern for substantial neurologic morbidity in the neonatal population has led to the generation of guidelines by both the American Academy of Pediatrics (AAP) and the Pediatric Endocrine Society (PES)...
April 2017: Pediatrics in Review
https://www.readbyqxmd.com/read/28355224/generation-of-infectious-recombinant-adeno-associated-virus-in-saccharomyces-cerevisiae
#17
Daniel Barajas, Juan Jose Aponte-Ubillus, Hassibullah Akeefe, Tomas Cinek, Joseph Peltier, Daniel Gold
The yeast Saccharomyces cerevisiae has been successfully employed to establish model systems for a number of viruses. Such model systems are powerful tools to study the virus biology and in particular for the identification and characterization of host factors playing a role in the viral infection cycle. Adeno-associated viruses (AAV) are heavily studied due to their use as gene delivery vectors. AAV relies on other helper viruses for successful replication and on host factors for several aspects of the viral life cycle...
2017: PloS One
https://www.readbyqxmd.com/read/28349182/biomechanical-comparison-of-anatomical-plating-systems-for-comminuted-distal-humeral-fractures
#18
Patrick A Varady, Christian von Rüden, Markus Greinwald, Sven Hungerer, Robert Pätzold, Peter Augat
PURPOSE: Six different mono-axial and poly-axial distal humeral plating systems with an anatomical plate design were compared. The aim of the biomechanical tests was to examine differences regarding system stiffness, median fatigue limit, and failure mechanisms. METHODS: Different configurations of two double plate fixation systems by two manufacturers for the treatment of complex distal humeral fractures (AO/OTA type C2.3) were biomechanically tested in a physiologically relevant setup...
March 27, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28348428/respiratory-syncytial-virus-infection-rates-with-limited-use-of-palivizumab-for-infants-born-at-29-to-31-6-7-weeks-gestational-age
#19
Brandi Newby, Todd Sorokan
BACKGROUND: Immunoprophylaxis with palivizumab can reduce respiratory syncytial virus (RSV) infections and hospitalizations. Criteria in British Columbia limit the use of palivizumab to infants born at 29 to 31+6/7 weeks gestational age, which differ from guidelines of the American Academy of Pediatrics (AAP) and the Canadian Paediatric Society (CPS). OBJECTIVE: To determine whether the limited use of palivizumab affected the frequency of hospital visits by RSV-positive infants (termed "RSV-positive hospital visits") who received approval for palivizumab and those who met the AAP/CPS criteria but did not receive approval for palivizumab...
January 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28344490/comparison-of-physicochemical-properties-of-suppositories-containing-starch-hydrolysates
#20
Piotr Belniak, Katarzyna Świąder, Michał Szumiło, Aleksandra Hyla, Ewa Poleszak
The purpose of this work was to determine the effect of starch hydrolysates (SH) on the physicochemical properties of suppositories. The study was conducted with suppositories with acetaminophen (AAP) a typical antipyretic analgesic, as model drug on lipophilic (cocoa butter) and hydrophilic base (polyethylene glycol 1500 + 400). The suppositories with and without the addition of SH were examined for physicochemical tests according to European Pharmacopoeia 8th edition (Ph. Eur.): the uniformity of mass of single-dose preparation test, the softening time determination of lipophilic suppositories test, the disintegration of suppositories test, and dissolution test with flow-through apparatus...
March 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
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