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https://www.readbyqxmd.com/read/29781242/photo-controlled-reversible-microtubule-assembly-mediated-by-cyclodextrin-derivative
#1
Ying-Ming Zhang, Ni-Yuan Zhang, Kui Xiao, Yu Liu, Qilin Yu
The design and construction of multistimuli-responsive supramolecular nanoassemblies that can mimic and regulate the fundamental biological processes has become a focus of interest in supramolecular chemistry. In this work, a perfect combination has been achieved between naturally occurring microtubule and artificially macrocyclic receptor. The self-assembling morphology of microtubules can be photo-tuned by the host-guest interaction of paclitaxel-modified β-cyclodextrin (PTX-CD) and photochromic arylazopyrazole (PTX-AAP)...
May 20, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29779714/self-monitoring-induced-savings-on-type-2-diabetes-patients-travel-and-healthcare-costs
#2
Aapeli Leminen, Markku Tykkyläinen, Tiina Laatikainen
BACKGROUND: Type 2 diabetes (T2DM) is a major health concern in most regions. In addition to direct healthcare costs, diabetes causes many indirect costs that are often ignored in economic analyses. Patients' travel and time costs associated with the follow-up of T2DM patients have not been previously calculated systematically over an entire healthcare district. The aim of the study was to develop a georeferenced cost model that could be used to measure healthcare accessibility and patient travel and time costs in a sparsely populated healthcare district in Finland...
July 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29779259/periodontal-status-among-elderly-inhabitants-of-northern-manhattan-the-whicap-ancillary-study-of-oral-health
#3
Jaffer A Shariff, Sandra Burkett, Caitlin Wei-Ming Watson, Bin Cheng, James M Noble, Panos N Papapanou
AIM: We conducted a cross-sectional study of the prevalence, extent and severity of periodontitis in a tri-ethnic cohort of ≥65 year-old participants of the Washington-Heights Inwood Community Aging Project (WHICAP). METHODS: 1,130 individuals (57% of eligible invitees) participated in a full-mouth periodontal examination that included assessments of bleeding on probing, pocket depth and clinical attachment loss (CAL) at six sites/tooth. RESULTS: Participants had a mean age of 75...
May 19, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29777781/screen-related-parenting-practices-in-low-income-mexican-american-families
#4
Darcy A Thompson, Sarah J Schmiege, Susan L Johnson, Elizabeth A Vandewater, Richard E Boles, Ruth E Zambrana, Jerusha Lev, Jeanne M Tschann
OBJECTIVES: To (1) examine whether the Information, Motivation, and Behavioral Skills Model predicts maternal screen-related parenting practices and (2) evaluate the relationship of American Academy of Pediatrics(AAP)-recommended parenting practices with child television (TV) use behaviors. METHODS: In this cross-sectional study, 312 Spanish- and/or English-speaking female primary caregivers of Mexican descent with a child 3-5 years of age were recruited from safety-net pediatric clinics...
May 16, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29768578/-work-accidents-and-automatic-circuit-reclosers-in-the-electricity-sector-beyond-the-immediate-causes
#5
Alessandro Jose Nunes da Silva, Ildeberto Muniz de Almeida, Rodolfo Andrade de Gouveia Vilela, Renata Wey Berti Mendes, Sandra Lorena Beltran Hurtado
The Brazilian electricity sector has recorded high work-related mortality rates that have been associated with outsourcing, used to cut costs. In order to decrease the power outage time for consumers, the industry adopted the automatic circuit recloser as the technical solution. The device has hazardous implications for maintenance workers. The aim of this study was to analyze the origins and consequences of work accidents in power systems with automatic circuit recloser, using the Accident Analysis and Prevention (AAP) model...
May 10, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29764238/successful-administration-of-bi-695501-an-adalimumab-biosimilar-using-an-autoinjector-ai-results-from-a-phase-ii-open-label-clinical-study-voltaire-%C3%A2-rl
#6
Stanley Cohen, Piotr A Klimiuk, Tillmann Krahnke, Deepak Assudani
BACKGROUND: This study examined the patient handling experience and self-injection success of patients with rheumatoid arthritis (RA) administering BI 695501 using an AI. METHODS: This Phase II, 7-week, open-label, interventional study (NCT02636907) included adult patients with moderately to severely active RA not adequately controlled by DMARDs, with no experience of self-injecting with AI/pen. Patients self-injected BI 695501 via AI every 2 weeks in the AI Assessment Period (AAP)...
May 15, 2018: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29757842/asthma-action-plans-in-the-adult-population-rediscovering-an-invaluable-tool-in-today-s-health-care-domain
#7
Jack Mayeux, Krysten Lisella Arekapudi, Azita Amiri
BACKGROUND AND PURPOSE: Asthma in adults remains a leading cause of morbidity, mortality, and increased health care costs. Asthma action plans (AAPs) have demonstrated improved health outcomes in this populace; however, AAPs continue to be underused by providers. This article aims to re-emphasize the importance of AAPs for adults and refresh providers on the effectiveness and methods to use this indispensable tool. METHODS: A literature search of MEDLINE, PubMed, Google Scholar, and CINAHL was performed, and subsequent findings were reported...
May 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29742436/the-assembly-activating-protein-promotes-stability-and-interactions-between-aav-s-viral-proteins-to-nucleate-capsid-assembly
#8
Anna C Maurer, Simon Pacouret, Ana Karla Cepeda Diaz, Jessica Blake, Eva Andres-Mateos, Luk H Vandenberghe
The adeno-associated virus (AAV) vector is a preferred delivery platform for in vivo gene therapy. Natural and engineered variations of the AAV capsid affect a plurality of phenotypes relevant to gene therapy, including vector production and host tropism. Fundamental to these aspects is the mechanism of AAV capsid assembly. Here, the role of the viral co-factor assembly-activating protein (AAP) was evaluated in 12 naturally occurring AAVs and 9 putative ancestral capsid intermediates. The results demonstrate increased capsid protein stability and VP-VP interactions in the presence of AAP...
May 8, 2018: Cell Reports
https://www.readbyqxmd.com/read/29741721/update-from-the-advisory-committee-on-immunization-practices
#9
Sean T O'Leary, David W Kimberlin, Yvonne A Maldonado
The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, each of whom is appointed to a 4-year term. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. The ACIP met on October 25 and 26, 2017, to discuss herpes zoster vaccine, the child/adolescent and adult vaccination schedules, Japanese encephalitis (JE) epidemiology and vaccines, pneumococcal vaccines, anthrax vaccines and disaster preparedness, hepatitis A outbreaks, influenza surveillance and vaccination coverage, vaccine safety, and considerations for a potential third dose of measles-mumps-rubella (MMR) vaccine to combat ongoing mumps outbreaks...
May 7, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29735842/role-of-insertion-sequence-element-is-256-as-a-virulence-marker-and-its-association-with-biofilm-formation-among-methicillin-resistant-staphylococcus-epidermidis-from-hospital-and-community-settings-in-chennai-south-india
#10
Saravanan Murugesan, Stalin Mani, Indhumathy Kuppusamy, Padma Krishnan
The objective of this study was to detect the association of biofilm formation with IS256 among clinical and carrier isolates of methicillin-resistant Staphylococcus epidermidis (MRSE). A total of 71 MRSE isolates were included in this study. Phenotypic detection of biofilm formation was done by Congo red agar method. Detection of genes associated with biofilm formation (icaAD, aap and atlE) and insertion sequence IS256 was done by polymerase chain reaction. Of the 71 MRSE isolates,19/40 (47.5%) clinical isolates from hospital settings and 11/31 (35...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29734817/cement-mantle-thickness-does-not-influence-serum-or-local-gentamicin-concentrations-in-hybrid-total-hip-arthroplasty-a-randomised-controlled-trial
#11
Willem van IJperen, Damien Van Quickenborne, Ronald Buyl, Thierry Scheerlinck
INTRODUCTION: We investigated the in vivo gentamicin elution kinetics of Hi-Fatigue Gentamicin Bone Cement (AAP Biomaterials GmbH) in serum and drain fluid after hybrid hip arthroplasty and the relationship with cement mantle thickness. METHODS: We compared in a randomised, non-blinded prospective study, the local and systemic gentamicin concentrations in 2 groups. The thin cement mantle group ( n = 16) received a stem implanted line-to-line with the broach, whereas the thick group ( n = 14) had an undersized stem...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29734233/association-of-academic-physiatrists-women-s-task-force-report
#12
Julie K Silver, Sara Cuccurullo, Anne Felicia Ambrose, Saurabha Bhatnagar, Glendaliz Bosques, Talya K Fleming, Walter R Frontera, Danielle Perret Karimi, Mooyeon Oh-Park, Gwendolyn Sowa, Christopher Visco, Lyn Weiss, Tiffany Knowlton
The Association of Academic Physiatrists (AAP) convened a women's task force in 2016, and the members agreed on a list of metrics that would permit retrospective data review pertaining to the representation and inclusion of women physicians in the society. Examples of categories examined included leadership positions (i.e., board membership, board presidents, committee membership, committee chairs, and resident fellow physician chairs), conference presentations (i.e., annual meeting session proposals, annual meeting faculty, annual meeting plenary speakers) and recognition awards (i...
April 30, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29726075/host-and-environmental-factors-influencing-candidatus-liberibacter-asiaticus-acquisition-in-diaphorina-citri
#13
Fengnian Wu, Jiaquan Huang, Meirong Xu, Eduardo G P Fox, G Andrew C Beattie, Paul Holford, Yijing Cen, Xiaoling Deng
BACKGROUND: Diaphorina citri is a vector of "Candidatus Liberibacter asiaticus" (CLas) associated with citrus Huanglongbing. In this study, the infection and titers of CLas in the psyllid, were monitored for life cycle stage, sex, host-plant CLas titer, host-plant genotype, and ambient temperature. RESULTS: Acquisition efficiency of CLas by D. citri was highest in nymphs reared at 25 °C on a host plant with high CLas titers but was independent of the host genotypes assessed and of vector sex...
May 3, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29722909/atypical-antipsychotic-exposure-may-not-differentiate-metabolic-phenotypes-of-patients-with-schizophrenia
#14
Kristen M Ward, Larisa Yeomans, Cora McHugh, A Zarina Kraal, Stephanie A Flowers, Amy E Rothberg, Alla Karnovsky, Arun Das, Vicki L Ellingrod, Kathleen A Stringer
STUDY OBJECTIVE: Patients with schizophrenia are known to have higher rates of metabolic disease than the general population. Contributing factors likely include lifestyle and atypical antipsychotic (AAP) use, but the underlying mechanisms are unknown. The objective of this study was to identify metabolomic variability in adult patients with schizophrenia who were taking AAPs and grouped by fasting insulin concentration, our surrogate marker for metabolic risk. DESIGN: Metabolomics analysis...
May 3, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29718669/smart-air-water-interfaces-with-arylazopyrazole-surfactants-and-their-role-in-photoresponsive-aqueous-foam
#15
Marco Schnurbus, Lucas Stricker, Bart Jan Ravoo, Björn Braunschweig
A new light-switchable azo-surfactant arylazopyrazole tetraethylene glycol carboxylic acid (AAP-E4 ) was used as a molecular building block to functionalize macroscopic foams. AAP-E4 was studied in the bulk solution with UV/Vis spectroscopy and at the interface with sum-frequency generation (SFG) as well as tensiometry. Additional foaming experiments were performed with a dynamic foam analyzer in order to study the role of AAP-E4 surfactants at the ubiquitous air/water interface as well as within macroscopic foam...
May 2, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29716464/-attachment-based-short-intervention-during-inpatient-treatment-of-adolescents
#16
Ann-Christin Jahnke-Majorkovits, Anna Buchheim
Attachment Based Short Intervention During Inpatient Treatment of Adolescents In clinical attachment research the established and economic Adult Attachment Projective Picture System (AAP) has been increasingly used in the past few years to assess the attachment representations in adults and recent studies demonstrated sufficient validity for assessing attachment representations in adolescents. Apart from coding attachment classifications, the AAP provides useful and clinically valid information concerning attachment related defences, aspects of capacity to act and synchrony in relationships and emotion regulation strategies with respect to attachment related traumatic experiences...
May 2018: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/29697579/acid-suppressing-drugs-and-a-low-1-level-of-antithrombin-as-risk-factors-for-l-asparaginase-associated-pancreatitis-a-case-control-study-in-the-japan-association-of-childhood-leukemia-study-jacls
#17
Yoshiko Hashii, Makoto Yoshida, Junichi Hara, Shinichiro Nishimura, Keiko Yumura-Yagi, Keizo Horibe, Tatsutoshi Nakahata
L-Asparaginase has significantly improved outcome for children with acute lymphoblastic leukemia and has become an essential component of multiagent chemotherapy. However, there are many adverse events due to L-asparaginase, including acute pancreatitis. The pathology of L-asparaginase-associated pancreatitis (AAP) remains unclear. We compared patients who developed AAP (n=29) and random matched controls (n=36) who had been enrolled in the Japan Association of Childhood Leukemia Study of the ALL-02 protocol...
April 24, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29695425/mapping-and-engineering-functional-domains-of-the-assembly-activating-protein-of-adeno-associated-viruses
#18
Longping V Tse, Sven Moller-Tank, Rita M Meganck, Aravind Asokan
Adeno-associated viruses (AAV) encode a unique assembly activating protein (AAP) within their genome that is essential for capsid assembly. Studies to date have focused on establishing the role of AAP as a chaperone that mediates stability, nucleolar transport, and assembly of AAV capsid proteins. Here, we map structure-function correlates of AAP using secondary structure analysis followed by deletion and substitutional mutagenesis of specific domains, namely, the hydrophobic N-terminal domain (HR), conserved core (CC), proline-rich region (PRR), threonine/serine rich region (T/S) and basic region (BR)...
April 25, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29693260/american-academy-of-periodontology-best-evidence-consensus-statement-on-the-efficacy-of-laser-therapy-used-alone-or-as-an-adjunct-to-non-surgical-and-surgical-treatment-of-periodontitis-and-peri-implant-diseases
#19
Michael P Mills, Paul S Rosen, Leandro Chambrone, Henry Greenwell, Richard T Kao, Perry R Klokkevold, Bradley S McAllister, Mark A Reynolds, Georgios E Romanos, Hom-Lay Wang
The American Academy of Periodontology (AAP) recently embarked on a Best Evidence Consensus (BEC) model of scientific inquiry to address questions of clinical importance in the treatment of periodontal and peri-implant diseases. For each focused question addressed below, there is a critical mass of evidence. However, standing alone, that evidence is, in the judgment of the Expert Panel convened by the AAP, insufficient to support broad conclusions and/or clinical practice guidelines. This article is protected by copyright...
April 25, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29691284/a-modified-algorithm-for-critical-congenital-heart-disease-screening-using-pulse-oximetry
#20
Christina L Diller, Michael S Kelleman, Kenneth G Kupke, Sharon C Quary, Lazaros K Kochilas, Matthew E Oster
: media-1vid110.1542/5727212367001PEDS-VA_2017-4065 Video Abstract OBJECTIVES: Determine the performance of the American Academy of Pediatrics (AAP) critical congenital heart disease (CCHD) newborn screening algorithm and the impact of an alternative algorithm. METHODS: Screening was performed on term infants without a known CCHD diagnosis at or near 24 hours of age at a tertiary birth hospital by using the AAP algorithm from 2013 to 2016. Retrospective review from the birth hospital and the area's sole pediatric cardiac center identified true- and false-positives and true- and false-negatives...
May 2018: Pediatrics
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