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https://www.readbyqxmd.com/read/28844776/return-to-play-and-complications-after-hook-of-the-hamate-fracture-surgery
#1
Anchal Bansal, Douglas Carlan, John Moley, Heather Goodson, Charles A Goldfarb
PURPOSE: The purpose of this study was to evaluate the efficacy of hook of the hamate excision for fracture in a large cohort of patients to better understand recovery time and complications. METHODS: We retrospectively reviewed the medical records of patients treated with surgical excision for hook of the hamate fractures at 2 different centers. We collected information on demographics, clinical presentation, and postoperative complications. Continuous outcome variables included time to surgery, return to play, and return to activity...
August 25, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28843672/in-vitro-metal-catalyzed-oxidative-stress-in-dah7ps-methionine-modification-leads-to-structure-destabilization-and-induce-amorphous-aggregation
#2
Anchal Sharma, Vijay Kumar, Apurva Chatrath, Aditya Dev, Ramasare Prasad, Ashwani Kumar Sharma, Shailly Tomar, Pravindra Kumar
The first committed step of the shikimate pathway is catalyzed by a metalloenzyme 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAH7PS), which exhibits vulnerability to the oxidative stress. DAH7PS undergoes inactivation in multiple ways in the presence of redox metal, H2O2, and superoxide. The molecular mechanism and susceptibility of its inactivation might differ in different organisms and are presently unclear. In the present work, we have cloned, expressed and purified a DAH7PS from Providencia alcalifaciens (PaDAH7PS)...
August 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28737955/meta-analysis-of-the-risk-of-infections-after-anterior-cruciate-ligament-reconstruction-by-graft-type
#3
Anchal Bansal, Joseph D Lamplot, James T Vandenberg, Robert H Brophy
BACKGROUND: An infection after anterior cruciate ligament (ACL) reconstruction is a relatively rare but challenging complication. There are no meta-analyses comparing the incidence of infections after ACL reconstruction with the various available graft choices. PURPOSE: To compare the incidence of infections after ACL reconstruction with bone-patellar tendon-bone (BPTB) autografts compared with hamstring autografts, with a secondary aim of comparing the incidence of infections after reconstruction with autografts compared with allografts...
July 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28550310/a-to-i-editing-in-human-mirnas-is-enriched-in-seed-sequence-influenced-by-sequence-contexts-and-significantly-hypoedited-in-glioblastoma-multiforme
#4
Deepanjan Paul, Ashis Narayan Sinha, Arjun Ray, Megha Lal, Subhashree Nayak, Anchal Sharma, Bharati Mehani, Debasish Mukherjee, Saurabh V Laddha, Ashish Suri, Chitra Sarkar, Arijit Mukhopadhyay
Editing in microRNAs, particularly in seed can significantly alter the choice of their target genes. We show that out of 13 different human tissues, different regions of brain showed higher adenosine to inosine (A-to-I) editing in mature miRNAs. These events were enriched in seed sequence (73.33%), which was not observed for cytosine to uracil (17.86%) editing. More than half of the edited miRNAs showed increased stability, 72.7% of which had ΔΔG values less than -6.0 Kcal/mole and for all of them the edited adenosines mis-paired with cytosines on the pre-miRNA structure...
May 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428657/x-ray-and-computed-tomography-findings-in-macrodystrophia-lipomatosa-of-the-foot-with-secondary-osteoarthritic-changes-diagnosed-in-an-elderly-female-a-case-report
#5
Rajesh Sharma, Puneet Gupta, Manik Mahajan, Manjit Arora, Anchal Gupta
Macrodystrophia lipomatosa is a rare entity that is mostly diagnosed in children. It has been very rarely reported in adults. Here, we describe the X-ray and computed tomography findings in a case of macrodystrophia lipomatosa in an elderly female presenting with an enlarged second toe since birth and bony outgrowths causing pressure effects and cosmetic problems.
March 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28376439/subclinical-peroneal-neuropathy-a-common-unrecognized-and-preventable-finding-associated-with-a-recent-history-of-falling-in-hospitalized-patients
#6
Louis H Poppler, Andrew P Groves, Gina Sacks, Anchal Bansal, Kristen M Davidge, Jenifer A Sledge, Heidi Tymkew, Yan Yan, Jessica M Hasak, Patricia Potter, Susan E Mackinnon
PURPOSE: Identification of modifiable risk factors for falling is paramount in reducing the incidence and morbidity of falling. Peroneal neuropathy with an overt foot drop is a known risk factor for falling, but research into subclinical peroneal neuropathy (SCPN) resulting from compression at the fibular head is lacking. The purpose of our study was to determine the prevalence of SCPN in hospitalized patients and establish whether it is associated with a recent history of falling. METHODS: We conducted a cross-sectional study of 100 medical inpatients at a large academic tertiary care hospital in St Louis, Missouri...
November 2016: Annals of Family Medicine
https://www.readbyqxmd.com/read/28137229/challenges-with-mosquito-borne-viral-diseases-outbreak-of-the-monsters
#7
REVIEW
Renu Gautam, Sweta Mishra, Archana Milhotra, Ritika Nagpal, Mradul Mohan, Anchal Singhal, Pratibha Kumari
BACKGROUND: The viruses responsible for mosquito-borne diseases are on an exploring mode, expanding their horizon, adapting to the situation and comfortably making their presence felt globally, from South Africa to Asia, Europe and United States. The current global scenario and recent documentations indicate towards the real monsters, outbreak of Zika, dengue and chikungunya viruses. Zika, dengue and chikungunya viruses are positive sense single-stranded RNA arbovirus and so their initial symptoms are almost 80% similar and all three are spread by mosquitos which bite during the day...
2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28128054/purification-and-characterization-of-2s-albumin-from-seeds-of-wrightia-tinctoria-exhibiting-antibacterial-and-dnase-activity
#8
Anchal Sharma, Pramod Kumar, Pooja Kesari, Neetu, Madhusudhanarao Katiki, Manisha Mishra, Pradhyumna K Singh, Bhola R Gurjar, Ashwani K Sharma, Shailly Tomar, Pravindra Kumar
2S albumin is a low-molecular-weight seed storage protein belonging to the prolamin superfamily. In the present work a small 2S albumin (WTA) protein of ~16 kDa has been purified from the seeds of Wrightia tinctoria. The WTA is a heterodimer protein with a small subunit of ~5 kDa and a larger subunit of ~11 kDa bridged together through disulphide bonds. The protein exhibits deoxyribonucleases activity against closed circular pBR322 plasmid DNA and linear BL21 genomic DNA. The protein also showed antibacterial activity against Morexalla catarrhalis...
2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28002212/ambulatory-surgical-centers-a-review-of-complications-and-adverse-events
#9
REVIEW
Charles A Goldfarb, Anchal Bansal, Robert H Brophy
An increasing number of orthopaedic surgeries are performed at ambulatory surgical centers (ASCs), as is exemplified by the 272% population-adjusted increase in outpatient rotator cuff repairs from 1996 to 2006. Outpatient surgery is convenient for patients and cost effective for the healthcare system. The rate of complications and adverse events following orthopaedic surgeries at ASCs ranges from 0.05% to 20%. The most common complications are pain and nausea, followed by infection, impaired healing, and bleeding; these are affected by surgical and patient risk factors...
January 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28000570/structural-functional-and-evolutionary-aspects-of-seed-globulins
#10
REVIEW
Pooja Kesari, Neetu, Anchal Sharma, Madhusudhanarao Katiki, Pramod Kumar, Bhola R Gurjar, Shailly Tomar, Ashwani K Sharma, Pravindra Kumar
Globulins are a major class of seed storage proteins which were thought to be enzymatically inactive. These proteins belong to the most ancient cupin superfamily. They can be graded into 11S legumin type and 7S vicilin type based on their sedimentation coefficients. Members from both classes share structural homology are thought to have evolved from either one-domain germin predecessor by duplication or by horizontal gene transfer of two-domain gene from bacteria to eukaryotes. Globulins are known to define the nutritional quality of the seeds, however, they are also involved in sucrose binding, desiccation, defense against microbes, hormone binding and oxidative stress etc...
2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/27907873/excellent-storage-stability-and-sensitive-detection-of-neurotoxin-quinolinic-acid
#11
Ranjana Singh, Sunayana Kashyap, Suveen Kumar, Shiju Abraham, Tejendra K Gupta, Arvind M Kayastha, Bansi D Malhotra, Preeti Suman Saxena, Anchal Srivastava, Ranjan K Singh
Quinolinic acid (QA) is a metabolite of tryptophan degradation obtained through kynurenine pathway, produced naturally in the mammalian brain as well as in the human cerebrospinal fluid. The presence of QA ~10-40µM is a clear indicator of many neurological disorders as well as deficiency of vitamin B6 in human being. In the present work; rapid, sensitive and cost-effective bio-electrodes were prepared to detect the trace amount of endogenous neurotoxin (QA). Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) studies were carried out to measure the electrochemical response of the fabricated bio-electrodes as a function of QA concentrations...
April 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27878209/preclinical-models-of-overwhelming-sepsis-implicate-the-neural-system-that-encodes-contextual-fear-memory
#12
Patricio T Huerta, Sergio Robbiati, Tomás Salvador Huerta, Anchal Sabharwal, Rose A Berlin, Maya Frankfurt, Bruce T Volpe
Long-term sepsis survivors sustain cryptic brain injury that leads to cognitive impairment, emotional imbalance, and increased disability burden. Suitable animal models of sepsis, such as cecal ligation and puncture (CLP), have permitted the analysis of abnormal brain circuits that underlie post-septic behavioral phenotypes. For instance, we have previously shown that CLP-exposed mice exhibit impaired spatial memory together with depleted dendritic arbors and decreased spines in the apical dendrites of pyramidal neurons in the CA1 region of the hippocampus...
November 17, 2016: Molecular Medicine
https://www.readbyqxmd.com/read/27826912/mirna-biogenesis-and-regulation-of-diseases-an-overview
#13
Anchal Vishnoi, Sweta Rani
MicroRNAs (miRNAs) are small RNA molecules, with their role in gene silencing and translational repression by binding to target mRNAs. Since it was discovered in 1993, miRNA are found in all eukaryotic cells conserved across the species. In recent years, regulation of miRNAs are extensively studied for their role in biological processes as well as in development and progression of various human diseases including retinal disorder, neurodegenerative diseases, cardiovascular disease and cancer. This chapter summarises miRNA biogenesis and explores their potential roles in a variety of diseases...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27818549/giant-nontraumatic-intradiploic-arachnoid-cyst-in-a-young-male
#14
Rajesh Sharma, Puneet Gupta, Manik Mahajan, Poonam Sharma, Anchal Gupta, Arti Khurana
Intradiploic arachnoid cysts have scarcely been reported in the literature, most reported cases being secondary to trauma. Nontraumatic arachnoid cysts are quite rare and have been reported mostly in adults. Here, we report the case of a 16-year-old male presenting with a slowly growing mass in the occipital region and intermittent headaches. On the basis of the findings of X-rays, computed tomography scans, and magnetic resonance imaging scans of the head, the mass was diagnosed as a giant intradiploic arachnoid cyst...
September 2016: Radiologia Brasileira
https://www.readbyqxmd.com/read/27746597/comparative-evaluation-of-border-molding-using-two-different-techniques-in-maxillary-edentulous-arches-a-clinical-study
#15
Anchal Qanungo, Meena Ajay Aras, Vidya Chitre, Ivy Coutinho, Praveen Rajagopal, Ashwin Mysore
PURPOSE: The aim of this in vivo study was to compare the single-step border molding technique using injectable heavy viscosity addition silicone with sectional border molding technique using low fusing impression compound by evaluating the retention of heat cure trial denture bases. MATERIALS AND METHODS: Ten completely edentulous patients in need of prostheses were included in this study. Two border molding techniques, single-step (Group 1) and sectional (Group 2), were compared for retention...
October 2016: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/27696078/quality-of-life-qol-and-symptom-burden-sb-in-patients-with-breast-cancer
#16
Julia Hamer, Rachel McDonald, Liying Zhang, Sunil Verma, Angela Leahey, Christine Ecclestone, Gillian Bedard, Natalie Pulenzas, Anchal Bhatia, Ronald Chow, Carlo DeAngelis, Janet Ellis, Eileen Rakovitch, Justin Lee, Edward Chow
PURPOSE: The purpose of this study was to determine the quality of life (QOL) and symptom burden (SB) among breast cancer patients. METHODS: Patients with DCIS, early stage, locally advanced, or metastatic breast cancer completed the Edmonton Symptom Assessment System (ESAS) and the Functional Assessment of Cancer Therapy for Breast Cancer (FACT-B). Patients were divided into subsequent cohorts based on their last day of treatment, age at enrollment, radiation, chemotherapy, and hormone therapy...
February 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27437350/assessment-and-evaluation-of-anatomic-variations-of-retromolar-pad-a-cross-sectional-study
#17
Anil Sharma, Anchal Deep, Amit Siwach, Manas Singh, Akshay Bhargava, Reenu Siwach
INTRODUCTION: The retromolar pad also called piriformis papilla is a mucosal elevation located in the retromolar area covering the retromolar triangle. After molar loss, the bony alveolar process and surrounding soft periodontal tissue remodel, mainly resorb and blend with retromolar pad. It is a key intraoral landmark in prosthodontics. AIM: The aim of this in-vitro study was to analyze the various anatomical shapes and sizes of retromolar pad in 150 completely edentulous patients between 55 to 70 years of age group...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27387086/cerebral-palsy-tendon-transfers-flexor-carpi-ulnaris-to-extensor-carpi-radialis-brevis-and-extensor-pollicis-longus-reroutement
#18
REVIEW
Anchal Bansal, Lindley B Wall, Charles A Goldfarb
The flexor carpi ulnaris to extensor carpi radialis brevis transfer and extensor pollicis longus rerouting combined with thenar release are 2 successful surgical interventions for children with spastic cerebral palsy. The goal of both procedures is to improve quality of life for patients who have previously failed conservative management, and the degree of expected improvement is predicated on several patient variables, making careful patient selection crucial for ensuring successful outcomes. Here, surgical technique is described; risk factors are discussed, and outcomes related to both procedures are presented...
August 2016: Hand Clinics
https://www.readbyqxmd.com/read/27298545/benefits-of-not-prescribing-prophylactic-antibiotics-after-third-molar-surgery
#19
Anchal Prajapati, Aalap Prajapati, Swati Sathaye
AIM AND OBJECTIVE: The aim of the study is to reinstate the fact that antibiotics are not required as prophylaxis for third molar surgery. So the standard of care after extraction of mandibular third molar surgery for all healthy patients should be a good anti-inflammatory regimen rather than a antibiotic prophylaxis. CONTEXT: Surgical removal of impacted mandibular third molar is the most common procedure and many complications are usually encountered in this procedure like-pain, trismus, infection, swelling, inflammation and nerve damage...
June 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27237136/radiosynthesis-of-18f-fluorobenzoate-doxorubicin-using-acylation-approach
#20
Pardeep Kumar, Ankit Watts, Pratap Acharya, Ranju Bansal, Anchal Ghai, Amritjyot Kaur, Baljinder Singh
BACKGROUND: Previously, we have labeled doxorubicin with [99Tc] and evaluated its potential as a SPECT agent to detect cancer in tumor bearing mice. In this study, we sought to radiolabel doxorubicin with [18F] using acylation method. METHODS: A quaternary salt of the precursor pentamethylbenzyl-4-(trimethylammonium trifluoromethanesulfonate) benzoate was synthesized and characterized by 1H-NMR. As a first step, 4-[18F]- fluorobenzoic acid (FBA) was synthesized from precursor...
2016: Current Radiopharmaceuticals
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