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https://www.readbyqxmd.com/read/29721703/functional-calixphyrins-synthetic-strategies-and-applications
#1
REVIEW
Anchal Singhal
Calixphyrins are hybrid macrocycles that contain both sp2 - and sp3 -hybridized carbon atoms and hence bear analogy to both porphyrins and calixpyrroles. Due to the presence of sp3 -hybridized carbon atoms, π-conjugation is disrupted in calixphyrins, which leads to conformational flexibility. Hence, these molecules find a use in anion binding, host-guest chemistry and metal-coordination chemistry. During the last decade, studies on calixphyrins have been a topic of wide interest to researchers. Various functionalities have been introduced to the structure of calixphyrins, leading to the development of expanded calixphyrins, core-modified calixphyrins and N-confused calixphyrins with diverse applications...
May 2, 2018: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/29676347/dual-energy-computed-tomography-a-reliable-and-established-tool-for-in-vivo-differentiation-of-uric-acid-from-nonuric-acid-renal-stones
#2
Mohd Ilyas, Ghanshyam Dev, Anchal Gupta, Tameem Ahmad Bhat, Shwait Sharma
Background: Dual-energy computed tomography (DECT) utilises the technique of simultaneous image acquisition of a body part at two different energy levels of the X-ray tubes. We used the DECT in this project to study its accuracy in non-invasive in vivo differentiation of uric acid (UA) calculi from non-UA calculi using the 3rd generation dual-source computed tomography (CT) scanner. Materials and Methods: The DECT ratios of the various stones were noted and compared with the postextraction analysis of stones for composition...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29672706/dissecting-the-sources-of-gene-expression-variation-in-a-pan-cancer-analysis-identifies-novel-regulatory-mutations
#3
Anchal Sharma, Chuan Jiang, Subhajyoti De
Although the catalog of cancer-associated mutations in protein-coding regions is nearly complete for all major cancer types, an assessment of regulatory changes in cancer genomes and their clinical significance remain largely preliminary. Adopting bottom-up approach, we quantify the effects of different sources of gene expression variation in a cohort of 3899 samples from 10 cancer types. We find that copy number alterations, epigenetic changes, transcription factors and microRNAs collectively explain, on average, only 31-38% and 18-26% expression variation for cancer-associated and other genes, respectively, and that among these factors copy number alteration has the highest effect...
April 17, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29662469/halotolerant-exiguobacterium-profundum-phm11-tolerate-salinity-by-accumulating-l-proline-and-fine-tuning-gene-expression-profiles-of-related-metabolic-pathways
#4
Vikas K Patel, Ruchi Srivastava, Anjney Sharma, Anchal K Srivastava, Savita Singh, Alok K Srivastava, Prem L Kashyap, Hillol Chakdar, K Pandiyan, Alok Kalra, Anil K Saxena
Salinity stress is one of the serious factors, limiting production of major agricultural crops; especially, in sodic soils. A number of approaches are being applied to mitigate the salt-induced adverse effects in agricultural crops through implying different halotolerant microbes. In this aspect, a halotolerant, Exiguobacterium profundum PHM11 was evaluated under eight different salinity regimes; 100, 250, 500, 1000, 1500, 2000, 2500, and 3000 mM to know its inherent salt tolerance limits and salt-induced consequences affecting its natural metabolism...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29604333/biophysical-and-in-silico-interaction-studies-of-aporphine-alkaloids-with-malonyl-coa-acp-transacylase-fabd-from-drug-resistant-moraxella-catarrhalis
#5
Vijay Kumar, Anchal Sharma, Shivendra Pratap, Pravindra Kumar
Malonyl-CoA:acyl carrier protein transacylase (FabD), being an essential enzyme of the FAS II pathway, is an attractive target for developing broad-spectrum antibiotics. It performs initiation reaction to form malonyl-ACP, which is a key building block in fatty acid biosynthesis. In this study, we have characterized the FabD from drug-resistant pathogen Moraxella catarrhalis (McFabD). More importantly, we have shown the binding of McFabD with three new compounds from the class of aporphine alkaloids. ITC based binding studies have shown that apomorphine is binding to McFabD with a stronger affinity (KD  = 4...
March 28, 2018: Biochimie
https://www.readbyqxmd.com/read/29601241/meta-analysis-of-the-risk-of-infections-after-anterior-cruciate-ligament-reconstruction-by-graft-type-response
#6
Robert H Brophy, Anchal Bansal, Joseph D Lamplot, James T Vandenberg
No abstract text is available yet for this article.
April 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29537030/unimolecular-decomposition-of-formamide-via-direct-chemical-dynamics-simulations
#7
Anchal Gahlaut, Manikandan Paranjothy
Formamide (NH2 CHO), being the simplest organic molecule containing an amide functional group, serves as a prototype to study protein and peptide chemistry. Formamide has been found in Comets and interstellar media and its decomposition results in smaller molecules such as NH3 , CO, HCN, HNCO, etc. These smaller molecules are considered to have been potential precursors for the formation of complex biological molecules, such as nucleic acids and nucleobases, in the early Earth. Several experimental and theoretical investigations of formamide decomposition have been reported in the literature...
March 14, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29491609/adenoid-cystic-carcinoma-of-palate-report-of-a-solid-variant
#8
Anchal Chandraprakash Srivastava, Suresh R Barpande, Jyoti D Bhavthankar, Mandakini S Mandale
Adenoid cystic carcinomas (ADCCs) are uncommon tumors, comprising < 1% of all head-and-neck cancers and 20%-25% of all salivary cancers. The most common presenting symptom of the lesion is a slowly growing mass followed by pain due to the propensity of these tumors for perineural invasion. The tumor is most often clinically deceptive by its small size and slow growth, which actually overlies its extensive subclinical invasion and marked ability for early metastasis making the prognosis questionable, aptly referred as "wolf in sheep's clothing...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29412942/fabrication-of-sensitive-bioelectrode-based-on-atomically-thin-cvd-grown-graphene-for-cancer-biomarker-detection
#9
Vijay K Singh, Saurabh Kumar, Sumit Kumar Pandey, Saurabh Srivastava, Monu Mishra, Govind Gupta, B D Malhotra, R S Tiwari, Anchal Srivastava
Motivation behind the present work is to fabricate a cost effective and scalable biosensing platform for an easy and reliable detection of cancer biomarker Carcinoembryonic antigen (CEA). Here, we report the sensitive and selective detection of CEA using graphene based bio-sensing platform. Large sized (~ 2.5 × 1.0cm2 ), uniform, continuous, single and few layers graphene films have been grown on copper (Cu) substrate employing chemical vapor deposition (CVD) technique using hexane as a liquid precursor. Functional group has been created over Graphene/Cu substrate through π-π stacking of 1- pyrenebutanoic acid succinimidyl ester (PBSE)...
May 15, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29242229/emerging-role-of-the-plant-erf-transcription-factors-in-coordinating-wound-defense-responses-and-repair
#10
REVIEW
Jefri Heyman, Balkan Canher, Anchal Bisht, Fien Christiaens, Lieven De Veylder
Plants react to wounding through the activation of both defense and repair pathways, but how these two responses are coordinated is unclear. Here, we put forward the hypothesis that diverse members of the subfamily X of the plant-specific ethylene response factor (ERF) transcription factors coordinate stress signaling with the activation of wound repair mechanisms. Moreover, we highlight the observation that tissue repair is strongly boosted through the formation of a heterodimeric protein complex that comprises ERF and transcription factors of the GRAS domain type...
January 29, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29143349/growth-rate-rather-than-growth-duration-drives-growth-heterosis-in-maize-b104-hybrids
#11
Kim Feys, Kirin Demuynck, Jolien De Block, Anchal Bisht, Alex De Vliegher, Dirk Inzé, Hilde Nelissen
Research in maize is often performed using inbred lines that can be readily transformed, such as B104. However, because the B104 line flowers late, the kernels do not always mature before the end of the growing season, hampering routine seed yield evaluations of biotech traits introduced in B104 at many geographical locations. Therefore, we generated five hybrids by crossing B104 with the early-flowering inbred lines CML91, F7, H99, Mo17, and W153R and showed in three consecutive years that the hybrid lines proved to be suitable to evaluate seed yield under field conditions in a temperate climate...
February 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29092780/characterization-of-isoflavonoids-as-inhibitors-of-%C3%AE-hydroxyacyl-acyl-carrier-protein-dehydratase-fabz-from-moraxella-catarrhalis-kinetics-spectroscopic-thermodynamics-and-in-silico-studies
#12
Vijay Kumar, Anchal Sharma, Shivendra Pratap, Pravindra Kumar
BACKGROUD: β-hydroxyacyl-acyl carrier protein dehydratase (FabZ) is an essential component of type II fatty acid biosynthesis (FAS II) pathway in bacteria. It performs dehydration of β-hydroxyacyl-ACP to trans-2-acyl-ACP in the elongation cycle of the FAS II pathway. FabZ is ubiquitously expressed and has uniform distribution, which makes FabZ an excellent target for developing novel drugs against pathogenic bacteria. METHODS: We focused on the biochemical and biophysical characterization of FabZ from drug-resistant pathogen Moraxella catarrhalis (McFabZ)...
March 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29054021/qprtase-modified-n-doped-carbon-quantum-dots-a-fluorescent-bioprobe-for-selective-detection-of-neurotoxin-quinolinic-acid-in-human-serum
#13
Ranjana Singh, Sunayana Kashayap, Vimal Singh, Arvind M Kayastha, Hirdyesh Mishra, Preeti Suman Saxena, Anchal Srivastava, Ranjan K Singh
Highly fluorescent nitrogen doped carbon quantum dots (NCQDs) were synthesized using microwave assisted green method. It was characterized by Transmission Electron Microscopy (TEM), FTIR, UV-Visible absorption and Photoluminiscence (PL) techniques. The NCQDs were immobilized with an enzyme named quinolinate phoshphoribosyl transferase (QPRTase). The NCQDs immobilized by QPRTase was used as a fluorescent bioprobe for the selective detection of endogenous neurotoxin quinolinic acid (QA) whose elevated level in serum is marker of many neurological disorders such as Alzheimer's, Huntington's and HIV associated dementia (HAD) as well as deficiency of vitamin B6...
October 10, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29025987/preclinical-development-of-cd38-targeted-89-zr-zr-dfo-daratumumab-for-imaging-multiple-myeloma
#14
Anchal Ghai, Dolonchampa Maji, Nicholas Cho, Chantiya Chanswangphuwana, Michael Rettig, Duanwen Shen, John DiPersio, Walter Akers, Farrokh Dehdashti, Samuel Achilefu, Ravi Vij, Monica Shokeen
Multiple myeloma (MM) is a plasma B-cell hematologic cancer that causes significant skeletal morbidity. Despite improvements in survival, heterogeneity in response remains a major challenge in MM. Cluster of differentiation 38 (CD38) is a type II transmembrane glycoprotein overexpressed in myeloma cells and is implicated in MM cell signaling. Daratumumab is a U.S. Food and Drug Administration-approved high-affinity monoclonal antibody targeting CD38 that is clinically benefiting refractory MM patients. Here, we evaluated [89 Zr]Zr-desferrioxamine (DFO)-daratumumab PET/CT imaging in MM tumor models...
February 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28967669/two-cyp716a-subfamily-cytochrome-p450-monooxygenases-of-sweet-basil-play-similar-but-nonredundant-roles-in-ursane-and-oleanane-type-pentacyclic-triterpene-biosynthesis
#15
Rajesh Chandra Misra, Shubha Sharma, Sandeep, Anchal Garg, Chandan Singh Chanotiya, Sumit Ghosh
The medicinal plant sweet basil (Ocimum basilicum) accumulates bioactive ursane- and oleanane-type pentacyclic triterpenes (PCTs), ursolic acid and oleanolic acid, respectively, in a spatio-temporal manner; however, the biosynthetic enzymes and their contributions towards PCT biosynthesis remain to be elucidated. Two CYP716A subfamily cytochrome P450 monooxygenases (CYP716A252 and CYP716A253) are identified from a methyl jasmonate-responsive expression sequence tag collection and functionally characterized, employing yeast (Saccharomyces cerevisiae) expression platform and adapting virus-induced gene silencing (VIGS) in sweet basil...
April 2017: New Phytologist
https://www.readbyqxmd.com/read/28965066/colorimetric-detection-of-cholesterol-based-on-enzyme-modified-gold-nanoparticles
#16
Narsingh R Nirala, Preeti S Saxena, Anchal Srivastava
We develop a simple colorimetric method for determination of free cholesterol in aqueous solution based on functionalized gold nanoparticles with cholesterol oxidase. Functionalized gold nanoparticles interact with free cholesterol to produce H2 O2 in proportion to the level of cholesterol visually is being detected. The quenching in optical properties and agglomeration of functionalized gold nanoparticles play a key role in cholesterol sensing due to the electron accepting property of H2 O2 . While the lower ranges of cholesterol (lower detection limit i...
February 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28844776/return-to-play-and-complications-after-hook-of-the-hamate-fracture-surgery
#17
Anchal Bansal, Douglas Carlan, John Moley, Heather Goodson, Charles A Goldfarb
PURPOSE: The purpose of this study was to evaluate the efficacy of hook of the hamate excision for fracture in a large cohort of patients to better understand recovery time and complications. METHODS: We retrospectively reviewed the medical records of patients treated with surgical excision for hook of the hamate fractures at 2 different centers. We collected information on demographics, clinical presentation, and postoperative complications. Continuous outcome variables included time to surgery, return to play, and return to activity...
October 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28843672/in-vitro-metal-catalyzed-oxidative-stress-in-dah7ps-methionine-modification-leads-to-structure-destabilization-and-induce-amorphous-aggregation
#18
Anchal Sharma, Vijay Kumar, Apurva Chatrath, Aditya Dev, Ramasare Prasad, Ashwani Kumar Sharma, Shailly Tomar, Pravindra Kumar
The first committed step of the shikimate pathway is catalyzed by a metalloenzyme 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase (DAH7PS), which exhibits vulnerability to the oxidative stress. DAH7PS undergoes inactivation in multiple ways in the presence of redox metal, H2 O2 , and superoxide. The molecular mechanism and susceptibility of its inactivation might differ in different organisms and are presently unclear. In the present work, we have cloned, expressed and purified a DAH7PS from Providencia alcalifaciens (PaDAH7PS)...
January 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28737955/meta-analysis-of-the-risk-of-infections-after-anterior-cruciate-ligament-reconstruction-by-graft-type
#19
Anchal Bansal, Joseph D Lamplot, James VandenBerg, Robert H Brophy
BACKGROUND: An infection after anterior cruciate ligament (ACL) reconstruction is a relatively rare but challenging complication. There are no meta-analyses comparing the incidence of infections after ACL reconstruction with the various available graft choices. PURPOSE: To compare the incidence of infections after ACL reconstruction with bone-patellar tendon-bone (BPTB) autografts compared with hamstring autografts, with a secondary aim of comparing the incidence of infections after reconstruction with autografts compared with allografts...
July 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28550310/a-to-i-editing-in-human-mirnas-is-enriched-in-seed-sequence-influenced-by-sequence-contexts-and-significantly-hypoedited-in-glioblastoma-multiforme
#20
Deepanjan Paul, Ashis Narayan Sinha, Arjun Ray, Megha Lal, Subhashree Nayak, Anchal Sharma, Bharati Mehani, Debasish Mukherjee, Saurabh V Laddha, Ashish Suri, Chitra Sarkar, Arijit Mukhopadhyay
Editing in microRNAs, particularly in seed can significantly alter the choice of their target genes. We show that out of 13 different human tissues, different regions of brain showed higher adenosine to inosine (A-to-I) editing in mature miRNAs. These events were enriched in seed sequence (73.33%), which was not observed for cytosine to uracil (17.86%) editing. More than half of the edited miRNAs showed increased stability, 72.7% of which had ΔΔG values less than -6.0 Kcal/mole and for all of them the edited adenosines mis-paired with cytosines on the pre-miRNA structure...
May 26, 2017: Scientific Reports
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