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https://www.readbyqxmd.com/read/27907873/excellent-storage-stability-and-sensitive-detection-of-neurotoxin-quinolinic-acid
#1
Ranjana Singh, Sunayana Kashyap, Suveen Kumar, Shiju Abraham, Tejendra K Gupta, Arvind M Kayastha, Bansi D Malhotra, Preeti Suman Saxena, Anchal Srivastava, Ranjan K Singh
Quinolinic acid (QA) is a metabolite of tryptophan degradation obtained through kynurenine pathway, produced naturally in the mammalian brain as well as in the human cerebrospinal fluid. The presence of QA ~10-40µM is a clear indicator of many neurological disorders as well as deficiency of vitamin B6 in human being. In the present work; rapid, sensitive and cost-effective bio-electrodes were prepared to detect the trace amount of endogenous neurotoxin (QA). Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) studies were carried out to measure the electrochemical response of the fabricated bio-electrodes as a function of QA concentrations...
November 23, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27878209/preclinical-models-of-overwhelming-sepsis-implicate-the-neural-system-that-encodes-contextual-fear-memory
#2
Patricio T Huerta, Sergio Robbiati, Tomás Salvador Huerta, Anchal Sabharwal, Rose A Berlin, Maya Frankfurt, Bruce T Volpe
Long-term sepsis survivors sustain cryptic brain injury that leads to cognitive impairment, emotional imbalance, and increased disability burden. Suitable animal models of sepsis, such as cecal ligation and puncture (CLP), have permitted the analysis of abnormal brain circuits that underlie post-septic behavioral phenotypes. For instance, we have previously shown that CLP-exposed mice exhibit impaired spatial memory together with depleted dendritic arbors and decreased spines in the apical dendrites of pyramidal neurons in the CA1 region of the hippocampus...
November 17, 2016: Molecular Medicine
https://www.readbyqxmd.com/read/27826912/mirna-biogenesis-and-regulation-of-diseases-an-overview
#3
Anchal Vishnoi, Sweta Rani
MicroRNAs (miRNAs) are small RNA molecules, with their role in gene silencing and translational repression by binding to target mRNAs. Since it was discovered in 1993, miRNA are found in all eukaryotic cells conserved across the species. In recent years, regulation of miRNAs are extensively studied for their role in biological processes as well as in development and progression of various human diseases including retinal disorder, neurodegenerative diseases, cardiovascular disease and cancer. This chapter summarises miRNA biogenesis and explores their potential roles in a variety of diseases...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27818549/giant-nontraumatic-intradiploic-arachnoid-cyst-in-a-young-male
#4
Rajesh Sharma, Puneet Gupta, Manik Mahajan, Poonam Sharma, Anchal Gupta, Arti Khurana
Intradiploic arachnoid cysts have scarcely been reported in the literature, most reported cases being secondary to trauma. Nontraumatic arachnoid cysts are quite rare and have been reported mostly in adults. Here, we report the case of a 16-year-old male presenting with a slowly growing mass in the occipital region and intermittent headaches. On the basis of the findings of X-rays, computed tomography scans, and magnetic resonance imaging scans of the head, the mass was diagnosed as a giant intradiploic arachnoid cyst...
September 2016: Radiologia Brasileira
https://www.readbyqxmd.com/read/27746597/comparative-evaluation-of-border-molding-using-two-different-techniques-in-maxillary-edentulous-arches-a-clinical-study
#5
Anchal Qanungo, Meena Ajay Aras, Vidya Chitre, Ivy Coutinho, Praveen Rajagopal, Ashwin Mysore
PURPOSE: The aim of this in vivo study was to compare the single-step border molding technique using injectable heavy viscosity addition silicone with sectional border molding technique using low fusing impression compound by evaluating the retention of heat cure trial denture bases. MATERIALS AND METHODS: Ten completely edentulous patients in need of prostheses were included in this study. Two border molding techniques, single-step (Group 1) and sectional (Group 2), were compared for retention...
October 2016: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/27696078/quality-of-life-qol-and-symptom-burden-sb-in-patients-with-breast-cancer
#6
Julia Hamer, Rachel McDonald, Liying Zhang, Sunil Verma, Angela Leahey, Christine Ecclestone, Gillian Bedard, Natalie Pulenzas, Anchal Bhatia, Ronald Chow, Carlo DeAngelis, Janet Ellis, Eileen Rakovitch, Justin Lee, Edward Chow
PURPOSE: The purpose of this study was to determine the quality of life (QOL) and symptom burden (SB) among breast cancer patients. METHODS: Patients with DCIS, early stage, locally advanced, or metastatic breast cancer completed the Edmonton Symptom Assessment System (ESAS) and the Functional Assessment of Cancer Therapy for Breast Cancer (FACT-B). Patients were divided into subsequent cohorts based on their last day of treatment, age at enrollment, radiation, chemotherapy, and hormone therapy...
September 30, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27437350/assessment-and-evaluation-of-anatomic-variations-of-retromolar-pad-a-cross-sectional-study
#7
Anil Sharma, Anchal Deep, Amit Siwach, Manas Singh, Akshay Bhargava, Reenu Siwach
INTRODUCTION: The retromolar pad also called piriformis papilla is a mucosal elevation located in the retromolar area covering the retromolar triangle. After molar loss, the bony alveolar process and surrounding soft periodontal tissue remodel, mainly resorb and blend with retromolar pad. It is a key intraoral landmark in prosthodontics. AIM: The aim of this in-vitro study was to analyze the various anatomical shapes and sizes of retromolar pad in 150 completely edentulous patients between 55 to 70 years of age group...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27387086/cerebral-palsy-tendon-transfers-flexor-carpi-ulnaris-to-extensor-carpi-radialis-brevis-and-extensor-pollicis-longus-reroutement
#8
REVIEW
Anchal Bansal, Lindley B Wall, Charles A Goldfarb
The flexor carpi ulnaris to extensor carpi radialis brevis transfer and extensor pollicis longus rerouting combined with thenar release are 2 successful surgical interventions for children with spastic cerebral palsy. The goal of both procedures is to improve quality of life for patients who have previously failed conservative management, and the degree of expected improvement is predicated on several patient variables, making careful patient selection crucial for ensuring successful outcomes. Here, surgical technique is described; risk factors are discussed, and outcomes related to both procedures are presented...
August 2016: Hand Clinics
https://www.readbyqxmd.com/read/27298545/benefits-of-not-prescribing-prophylactic-antibiotics-after-third-molar-surgery
#9
Anchal Prajapati, Aalap Prajapati, Swati Sathaye
AIM AND OBJECTIVE: The aim of the study is to reinstate the fact that antibiotics are not required as prophylaxis for third molar surgery. So the standard of care after extraction of mandibular third molar surgery for all healthy patients should be a good anti-inflammatory regimen rather than a antibiotic prophylaxis. CONTEXT: Surgical removal of impacted mandibular third molar is the most common procedure and many complications are usually encountered in this procedure like-pain, trismus, infection, swelling, inflammation and nerve damage...
June 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27237136/radiosynthesis-of-18f-fluorobenzoate-doxorubicin-using-acylation-approach
#10
Pardeep Kumar, Ankit Watts, Pratap Acharya, Ranju Bansal, Anchal Ghai, Amritjyot Kaur, Baljinder Singh
This study describes the two steps method for radio synthesis of fluorine-18 [18F] labeled doxorubicin. A quaternary salt of the precursor pentamethylbenzyl-4-(trimethylammonium trifluoromethanesulfonate) benzoate was synthesized and characterized. As a first step, 4-[18F]-fluorobenzoic acid (FBA) was synthesized from precursor and used as an intermediate to label doxorubicin. In the second step, [18F]-FBA was attached to the primary amine of doxorubicin by acylation reaction. The total reaction time for the synthesis of [18F]-FBA-doxorubicin was about 60 minutes...
May 30, 2016: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/27131858/immediate-dentin-sealing-for-indirect-bonded-restorations
#11
Anchal Qanungo, Meena Ajay Aras, Vidya Chitre, Ashwin Mysore, Bhavya Amin, Sohil Rajkumar Daswani
PURPOSE: The aim of this article is to review available literature on the clinical procedure of immediate dentine sealing for indirect bonded restorations. STUDY SELECTION: More than 40 articles reporting the technique, studies, outcomes, etc. were reviewed after PUBMED/MEDLINE search, most of them addressing the specific situation of dentin bonding for indirect restorations. RESULTS: It is known that tooth preparation for indirect bonded restorations can result in significant dentin exposures...
April 27, 2016: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/27129843/quality-of-life-and-symptom-burden-in-patients-with-metastatic-breast-cancer
#12
Christine Ecclestone, Ronald Chow, Natalie Pulenzas, Liying Zhang, Angela Leahey, Julia Hamer, Carlo DeAngelis, Gillian Bedard, Rachel McDonald, Anchal Bhatia, Janet Ellis, Eileen Rakovitch, Sherlyn Vuong, Edward Chow, Sunil Verma
PURPOSE: The goal of this study was to examine the symptom burden (SB) and quality of life (QOL) in patients with metastatic breast cancer. METHODS: Breast cancer patients with metastases were asked to complete the Edmonton Symptom Assessment System (ESAS) and FACT-B questionnaires. Statistical analysis was performed to identify (1) any differences in SB and QOL between patients with bone metastases only and patients with visceral +/- bone metastases and (2) any associations between SB and/or QOL and various clinical factors, including treatment with bisphosphonates, participation in a clinical trial and presence of brain metastases...
September 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27113675/analysis-of-chemical-warfare-agents-in-organic-liquid-samples-with-magnetic-dispersive-solid-phase-extraction-and-gas-chromatography-mass-spectrometry-for-verification-of-the-chemical-weapons-convention
#13
Varoon Singh, Ajay Kumar Purohit, Sridhar Chinthakindi, Raghavender D Goud, Vijay Tak, Deepak Pardasani, Anchal Roy Shrivastava, Devendra Kumar Dubey
A simple, sensitive and low temperature sample preparation method is developed for detection and identification of Chemical Warfare Agents (CWAs) and scheduled esters in organic liquid using magnetic dispersive solid phase extraction (MDSPE) followed by gas chromatography-mass spectrometry analysis. The method utilizes Iron oxide@Poly(methacrylic acid-co-ethylene glycol dimethacrylate) resin (Fe2O3@Poly(MAA-co-EGDMA)) as sorbent. Variants of these sorbents were prepared by precipitation polymerization of methacrylic acid-co-ethylene glycol dimethacrylate (MAA-co-EGDMA) onto Fe2O3 nanoparticles...
May 27, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27097308/synthesis-characterization-and-tribological-evaluation-of-tio2-reinforced-boron-and-nitrogen-co-doped-reduced-graphene-oxide-based-hybrid-nanomaterials-as-efficient-antiwear-lubricant-additives
#14
Vinay Jaiswal, Kalyani, Sima Umrao, Rashmi B Rastogi, Rajesh Kumar, Anchal Srivastava
The microwave-synthesized reduced graphene oxide (MRG), boron-doped reduced graphene oxide (B-MRG), nitrogen-doped reduced graphene oxide (N-MRG), boron-nitrogen-co-doped reduced graphene oxide (B-N-MRG), and TiO2-reinforced B-N-MRG (TiO2-B-N-MRG) nanomaterials have been synthesized and characterized by various state-of-the-art techniques, like Raman spectroscopy, powder X-ray diffraction, scanning electron microscopy (SEM) with energy-dispersive X-ray spectroscopy, high-resolution transmission electron microscopy, and X-ray photoelectron spectroscopy...
May 11, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27001270/genetic-association-and-stress-mediated-down-regulation-in-trabecular-meshwork-implicates-mpp7-as-a-novel-candidate-gene-in-primary-open-angle-glaucoma
#15
Mansi Vishal, Anchal Sharma, Lalit Kaurani, Giovanna Alfano, Suddhasil Mookherjee, Kiran Narta, Jyoti Agrawal, Iman Bhattacharya, Susanta Roychoudhury, Jharna Ray, Naushin H Waseem, Shomi S Bhattacharya, Analabha Basu, Abhijit Sen, Kunal Ray, Arijit Mukhopadhyay
BACKGROUND: Glaucoma is the largest cause of irreversible blindness affecting more than 60 million people globally. The disease is defined as a gradual loss of peripheral vision due to death of Retinal Ganglion Cells (RGC). The RGC death is largely influenced by the rate of aqueous humor production by ciliary processes and its passage through the trabecular meshwork (TM) in the anterior part of the eye. Primary open angle glaucoma (POAG), the most common subtype, is a genetically complex disease...
2016: BMC Medical Genomics
https://www.readbyqxmd.com/read/26814366/magnetic-hydrophilic-lipophilic-balance-sorbent-for-efficient-extraction-of-chemical-warfare-agents-from-water-samples
#16
Varoon Singh, Ajay Kumar Purohit, Sridhar Chinthakindi, Raghavender Goud D, Vijay Tak, Deepak Pardasani, Anchal Roy Shrivastava, Devendra Kumar Dubey
Magnetic hydrophilic-lipophilic balance (MHLB) hybrid resin was prepared by precipitation polymerization using N-vinylpyrrolidone (PVP) and divinylbenzene (DVB) as monomers and Fe2O3 nanoparticles as magnetic material. These resins were successfully applied for the extraction of chemical warfare agents (CWAs) and their markers from water samples through magnetic dispersive solid-phase extraction (MDSPE). By varying the ratios of monomers, resin with desired hydrophilic-lipophilic balance was prepared for the extraction of CWAs and related esters of varying polarities...
February 19, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/26563182/quality-of-life-and-symptom-burden-in-patients-with-breast-cancer-treated-with-mastectomy-and-lumpectomy
#17
Ronald Chow, Natalie Pulenzas, Liying Zhang, Christine Ecclestone, Angela Leahey, Julia Hamer, Carlo DeAngelis, Gillian Bedard, Rachel McDonald, Anchal Bhatia, Janet Ellis, Eileen Rakovitch, Sherlyn Vuong, Edward Chow, Sunil Verma
INTRODUCTION: Mastectomy (MAS) and lumpectomy (LUMP) are the two common local surgical treatments for early breast cancer. There has been a debate whether MAS or LUMP results in better quality of life (QOL). The purpose of this study was to examine the symptom burden (SB) and QOL of both MAS and LUMP patients. METHODS: Patients at the Louise Temerty Breast Cancer Centre in Toronto, Canada, were approached to complete two self-administered questionnaires, the Edmonton Symptom Assessment Score (ESAS) and the Functional Assessment of Cancer Therapy-Breast (FACT-B) cancer edition...
May 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/26547427/high-performance-and-high-sensitivity-applications-of-graphene-transistors-with-self-assembled-monolayers
#18
Chao-Hui Yeh, Vinod Kumar, David Ricardo Moyano, Shao-Hsuan Wen, Vyom Parashar, She-Hsin Hsiao, Anchal Srivastava, Preeti S Saxena, Kun-Ping Huang, Chien-Chung Chang, Po-Wen Chiu
Charge impurities and polar molecules on the surface of dielectric substrates has long been a critical obstacle to using graphene for its niche applications that involve graphene's high mobility and high sensitivity nature. Self-assembled monolayers (SAMs) have been found to effectively reduce the impact of long-range scatterings induced by the external charges. Yet, demonstrations of scalable device applications using the SAMs technique remains missing due to the difficulties in the device fabrication arising from the strong surface tension of the modified dielectric environment...
March 15, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/26475187/involvement-of-an-ent-copalyl-diphosphate-synthase-in-tissue-specific-accumulation-of-specialized-diterpenes-in-andrographis-paniculata
#19
Rajesh Chandra Misra, Anchal Garg, Sudeep Roy, Chandan Singh Chanotiya, Prema G Vasudev, Sumit Ghosh
Ent-labdane-related diterpene (ent-LRD) specialized (i.e. secondary) metabolites of the medicinal plant kalmegh (Andrographis paniculata) have long been known for several pharmacological activities. However, our understanding of the ent-LRD biosynthetic pathway has remained largely incomplete. Since ent-LRDs accumulate in leaves, we carried out a comparative transcriptional analysis using leaf and root tissues, and identified 389 differentially expressed transcripts, including 223 transcripts that were preferentially expressed in leaf tissue...
November 2015: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/26452886/partially-reduced-graphene-oxide-gold-nanorods-composite-based-bioelectrode-of-improved-sensing-performance
#20
Narsingh R Nirala, Shiju Abraham, Vinod Kumar, Shobhit A Pandey, Umakant Yadav, Monika Srivastava, S K Srivastava, Vidya Nand Singh, Arvind M Kayastha, Anchal Srivastava, Preeti S Saxena
The present work proposes partially reduced graphene oxide-gold nanorods supported by chitosan (CH-prGO-AuNRs) as a potential bioelectrode material for enhanced glucose sensing. Developed on ITO substrate by immobilizing glucose oxidase on CH-prGO-AuNRs composite, these CH-prGO-AuNRs/ITO bioelectrodes demonstrate high sensitivity of 3.2 µA/(mg/dL)/cm(2) and linear range of 25-200 mg/dL with an ability to detect as low as 14.5 mg/dL. Further, these CH-prGO-AuNRs/ITO based electrodes attest synergistiacally enhanced sensing properties when compared to simple graphene oxide based CH-GO/ITO electrode...
November 1, 2015: Talanta
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