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https://www.readbyqxmd.com/read/28816722/omega-3-fatty-acids-in-rheumatic-diseases-a-critical-review
#1
Umair Akbar, Melissa Yang, Divya Kurian, Chandra Mohan
Many clinical trials of omega-3 fatty acids, supplied as fish oil supplements, have been carried out in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), lupus nephritis, and osteoarthritis (OA) over the past 3 decades. This review attempts to summarize the highlights of these studies to evaluate the clinical efficacy for omega-3 fatty acids to be added alongside existing treatment regimens. A total of 20 clinical trials have been carried out in RA, of which 16 exhibited significant improvements in multiple disease clinical outcomes...
August 15, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28814877/mechanism-and-therapeutic-effectiveness-of-nerve-growth-factor-in-osteoarthritis-pain
#2
REVIEW
Xiushuai Shang, Zhaofei Wang, Hairong Tao
Osteoarthritis (OA) is the most common form of articular joint arthritis and a cause of significant morbidity. In this review, we present the role of nerve growth factor (NGF) in pain generation, relationship between NGF and OA pain, and pathogenic factors (interleukin-1β, transforming growth factor-β1, mechanical loading, and adipokines) involved in OA development. Since NGF blocking is an efficient way to inhibit OA-associated pain, we summarize four categories of drugs that target NGF/tropomyosin receptor kinase A (TrkA) signaling...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28812968/jnk-pathway-in-osteoarthritis-pathological-and-therapeutic-aspects
#3
Hong-Xing Ge, Fu-Man Zou, Yan Li, An-Min Liu, Min Tu
CONTEXT: Osteoarthritis (OA) is a common chronic degenerative joint disease resulting in physical disability and reduced quality of life. Different biochemical signaling pathways are involved in the progression of OA, including the c-Jun NH2-terminal kinase (JNK) signal transduction pathway. OBJECTIVE: In this study, we have reviewed the recent updates on the association of JNK pathway with OA. METHODS: In this review, we have explored the databases like PubMed, Google Scholar, Medline, Scopus, etc...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28803906/viscosupplementation-for-hip-osteoarthritis-a-systematic-review-and-meta-analysis-of-the-efficacy-for-pain-disability-and-adverse-events
#4
REVIEW
Victor Figueiredo Leite, João Eduardo Daud Amadera, Anna Maria Buehler
OBJECTIVE: To assess the efficacy of viscosupplementation (HA) in hip osteoarthritis (OA) pain, disability and adverse events. DATA SOURCES: Pubmed, EMBASE, Cochrane Library, ClinicalTrials.gov database and specific journals up to March 2017. STUDY SELECTION: Randomized controlled trials comparing HA with any other intra-articular injection. DATA EXTRACTION: Performed according to Cochrane/GRADE criteria. Two authors extracted data, assessed risk of bias and quality of evidence...
August 10, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28802534/cheilectomy-for-treatment-of-symptomatic-distal-interphalangeal-joint-osteoarthritis-a-review-of-78-patients
#5
Edward A Lin, Loukia K Papatheodorou, Dean G Sotereanos
PURPOSE: To determine whether open cheilectomy and debridement of the distal interphalangeal (DIP) joint is a safe and effective alternative to joint arthrodesis for the treatment of symptomatic osteoarthritis. METHODS: Seventy-eight patients with symptomatic DIP joint osteoarthritis and with a minimum follow-up of 24 months were retrospectively reviewed. Preoperative radiographs were graded. Open cheilectomy and debridement of the DIP joint was performed in all patients...
August 9, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28801413/effectiveness-of-rehabilitation-after-a-total-hip-arthroplasty-a-protocol-for-an-observational-study-for-the-comparison-of-usual-care-in-the-netherlands-versus-germany
#6
Gesine H Seeber, Annet Wijnen, Djordje Lazovic, Sjoerd K Bulstra, Günter Dietz, Christiaan P van Lingen, Martin Stevens
INTRODUCTION: Osteoarthritis is the most common joint disorder worldwide. Total hip arthroplasty (THA) is considered one of the most effective treatments for end-stage hip osteoarthritis. The number of THAs is expected to increase dramatically in the coming decades. Usual postoperative rehabilitation after primary THA differs between the German and the Dutch system. In the Netherlands, patients undergo fast-track surgery and are discharged into their home environment within a few days without receiving any aftercare...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28800252/progressive-changes-in-walking-kinematics-and-kinetics-after-anterior-cruciate-ligament-injury-and-reconstruction-a-review-and-meta-analysis
#7
Lindsay V Slater, Joseph M Hart, Adam R Kelly, Christopher M Kuenze
CONTEXT:   Anterior cruciate ligament (ACL) injury and ACL reconstruction (ACLR) result in persistent alterations in lower extremity movement patterns. The progression of lower extremity biomechanics from the time of injury has not been described. OBJECTIVE:   To compare the 3-dimensional (3D) lower extremity kinematics and kinetics of walking among individuals with ACL deficiency (ACLD), individuals with ACLR, and healthy control participants from 3 to 64 months after ACLR...
August 11, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28797874/factors-affecting-articular-cartilage-repair-after-open-wedge-high-tibial-osteotomy
#8
Chang-Wan Kim, Seung-Suk Seo, Chang-Rack Lee, Heui-Chul Gwak, Jung-Han Kim, Sun-Gyu Jung
BACKGROUND: To evaluate the factors that affect articular cartilage repair after open-wedge high tibial osteotomy (OWHTO) and the relationship between regeneration of articular cartilage repair and clinical outcomes. METHODS: Among the cases of OWHTO that were performed from March 2005 to February 2012, the patients who followed up for >2years and received a second-look arthroscopy were retrospectively reviewed. For clinical evaluation, the Knee Society scores and Western Ontario and McMaster Universities Osteoarthritis Index score were measured...
August 8, 2017: Knee
https://www.readbyqxmd.com/read/28792646/clinical-applications-of-chemical-exchange-saturation-transfer-cest-mri
#9
Kyle M Jones, Alyssa C Pollard, Mark D Pagel
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has been developed and employed in multiple clinical imaging research centers worldwide. Selective radiofrequency (RF) saturation pulses with standard 2D and 3D MRI acquisition schemes are now routinely performed, and CEST MRI can produce semiquantitative results using magnetization transfer ratio asymmetry (MTRasym ) analysis while accounting for B0 inhomogeneity. Faster clinical CEST MRI acquisition methods and more quantitative acquisition and analysis routines are under development...
August 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28790486/the-role-of-aging-in-the-development-of-osteoarthritis
#10
Richard F Loeser
Osteoarthritis (OA) is the most common form of arthritis and a significant cause of pain and disability in older adults. Among the risk factors for OA, age is the most prominent. This review will discuss the relationship between aging and the development of OA, with a particular focus on mechanisms relevant to cartilage degeneration and the role of excessive levels of reactive oxygen species. Rather than just causing random oxidative damage, an increase in reactive oxygen species that leads to oxidative stress disrupts specific cell signaling pathways...
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28790471/should-total-hip-arthroplasty-be-performed-acutely-in-the-treatment-of-acetabular-fractures-in-elderly-or-used-as-a-salvage-procedure-only
#11
Katharine Hamlin, Gabija Lazaraviciute, Michalis Koullouros, Tarak Chouari, Iain M Stevenson, Steven W Hamilton
BACKGROUND: Total hip arthroplasty (THA) is now an increasingly common procedure for people sustaining acetabular fractures. The incidence of acetabular fractures among the elderly population is increasing, and contemporary treatment aims to avoid the risks of prolonged incumbency associated with poor bone stock for fixation or inability to comply with limited weightbearing in this patient group. The concept of acute hip arthroplasty as a treatment for acetabular fracture is, therefore, becoming more topical and relevant...
July 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28782470/novel-insights-into-the-pathogenesis-of-osteoarthritis
#12
Matthias Geyer, C Schönfeld
Osteoarthritis represents the most frequently diagnosed condition of the musculoskeletal system and accounts for a high amount of direct and indirect socioeconomic costs worldwide. While for rheumatoid arthritis much progress has been made in the past decades both in understanding its pathogenesis and in creating novel therapies, the pathophysiology of osteoarthritis still holds several secrets to be unraveled in the near future in order to also allow for the development of effective novel pharmacotherapeutical options...
August 7, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28779923/cupping-therapy-for-treating-knee-osteoarthritis-the-evidence-from-systematic-review-and-meta-analysis
#13
REVIEW
Jin-Quan Li, Wen Guo, Ze-Gan Sun, Qing-Song Huang, En Yeong Lee, Ying Wang, Xiao-Dong Yao
OBJECTIVE: Cupping therapy is widely used in East Asia, the Middle East, or Central and North Europe to manage the symptom of knee osteoarthritis (KOA). The purpose of this systematic review was to evaluate the available evidence from randomized controlled trials (RCTs) of cupping therapy for treating patients with KOA. METHODS: The following databases were searched from their inception until January 2017: PubMed, Embase, the Cochrane Central Register of Controlled Trials and four Chinese databases [WanFang Med Database, Chinese BioMedical Database, Chinese WeiPu Database, and China National Knowledge Infrastructure (CNKI)]...
August 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28774716/aging-and-osteoarthritis-central-role-of-the-extracellular-matrix
#14
REVIEW
Maryam Rahmati, Giovanna Nalesso, Ali Mobasheri, Masoud Mozafari
Osteoarthritis (OA), is a major cause of severe joint pain, physical disability and quality of life impairment in the aging population across the developed and developing world. Increased catabolism in the extracellular matrix (ECM) of the articular cartilage is a key factor in the development and progression of OA. The molecular mechanisms leading to an impaired matrix turnover have not been fully clarified, however cellular senescence, increased expression of inflammatory mediators as well as oxidative stress in association with an inherently limited regenerative potential of the tissue, are all important contributors to OA development...
July 31, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28774457/conventional-radiology-in-crystal-arthritis-gout-calcium-pyrophosphate-deposition-and-basic-calcium-phosphate-crystals
#15
REVIEW
Thibaut Jacques, Paul Michelin, Sammy Badr, Michelangelo Nasuto, Guillaume Lefebvre, Neal Larkman, Anne Cotten
This article reviews the main radiographic features of crystal deposition diseases. Gout is linked to monosodium urate crystals. Classic radiographic features include subcutaneous tophi, large and well-circumscribed paraarticular bone erosions, and exuberant bone hyperostosis. Calcium pyrophosphate deposition (CPPD) can involve numerous structures, such as hyaline cartilages, fibrocartilages, or tendons. CPPD arthropathy involves joints usually spared by osteoarthritis. Basic calcium phosphate deposits are periarticular or intraarticular...
September 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28768437/clinical-descriptors-for-the-recognition-of-central-sensitization-pain-in-patients-with-knee-osteoarthritis
#16
Enrique Lluch, Jo Nijs, Carol A Courtney, Trudy Rebbeck, Vikki Wylde, Isabel Baert, Timothy H Wideman, Nick Howells, Søren T Skou
BACKGROUND: Despite growing awareness of the contribution of central pain mechanisms to knee osteoarthritis pain in a subgroup of patients, routine evaluation of central sensitization is yet to be incorporated into clinical practice. AIM: The objective of this perspective is to design a set of clinical descriptors for the recognition of central sensitization in patients with knee osteoarthritis that can be implemented in clinical practice. METHODS: A narrative review of original research papers was conducted by nine clinicians and researchers from seven different countries to reach agreement on clinically relevant descriptors...
August 2, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28767924/elderly-with-knee-osteoarthritis-should-perform-nutritional-assessment-integrative-literature-review
#17
Isabelle Ferreira da Silva Souza, Rosa Sá de Oliveira Neta, Juliana Maria Gazzola, Marcelo Cardoso de Souza
To review scientific literature to assess nutritional status of elderly patients with osteoarthritis in the last 16 years. This is an integrative literature review that included articles published in national and international journals indexed in PubMed, SciELO and BIREME. We selected 14 articles, and English language was predominant. The year of publication of articles ranged from 2006 to 2016, and most of papers were cross-sectional studies. To gather papers and for posterior evaluate, we used a validated data collection instrument and the included studies were critical analyzed by reading, gathering and analysis of articles...
April 2017: Einstein
https://www.readbyqxmd.com/read/28760147/the-2016-high-heels-health-effects-and-psychosexual-benefits-high-habits-study-systematic-review-of-reviews-and-additional-primary-studies
#18
Max Barnish, Heather May Morgan, Jean Barnish
BACKGROUND: High-heeled shoes (high heels) are frequently worn by many women and form an important part of female gender identity. Issues of explicit and implicit compulsion to wear high heels have been noted. Previous studies and reviews have provided evidence that high heels are detrimental to health. However, the evidence base remains fragmented and no review has covered both the epidemiological and biomechanical literature. In addition, no review has considered the psychosexual benefits that offer essential context in understanding the public health challenge of high heels...
August 1, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28758052/role-of-microrna-in-osteoarthritis
#19
Mingcai Zhang, Kate Lygrisse, Jinxi Wang
Although the potential effect of aberrant expression of catabolic and anabolic genes on the development of osteoarthritis (OA) is well-documented, the regulatory mechanism for the expression of these genes in articular chondrocytes remains to be elucidated. The recent advances in epigenetic studies have identified microRNA (miRNA) as one of the epigenetic mechanisms for the regulation of gene expression. This mini review highlights the role of miRNA in the regulation of gene expression in articular chondrocytes and its significance in the pathogenesis of OA, with a discussion on the potential of miRNA as a new biomarker and therapeutic target for OA...
April 2017: Journal of arthritis
https://www.readbyqxmd.com/read/28754801/subgroup-analyses-of-the-effectiveness-of-oral-glucosamine-for-knee-and-hip-osteoarthritis-a-systematic-review-and-individual-patient-data-meta-analysis-from-the-oa-trail-bank
#20
Jos Runhaar, Rianne M Rozendaal, Marienke van Middelkoop, Hans J W Bijlsma, Michael Doherty, Krysia S Dziedzic, L Stefan Lohmander, Timothy McAlindon, Weiya Zhang, Sita Bierma Zeinstra
OBJECTIVE: To evaluate the effectiveness of oral glucosamine in subgroups of people with hip or knee osteoarthritis (OA) based on baseline pain severity, body mass index (BMI), sex, structural abnormalities and presence of inflammation using individual patient data. METHODS: After a systematic search of the literature and clinical trial registries, all randomised controlled trials (RCTs) evaluating the effect of any oral glucosamine substance in patients with clinically or radiographically defined hip or knee OA were contacted...
July 28, 2017: Annals of the Rheumatic Diseases
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