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https://www.readbyqxmd.com/read/27908573/does-the-age-of-a-patient-affect-the-outcome-of-temporomandibular-joint-arthroscopic-surgery
#1
Jungsuk Cho, Howard Israel
PURPOSE: Although temporomandibular joint (TMJ) disorders encompass all age groups, it is generally considered to affect young to middle-age adults. The aim of this investigation was to study patients who met the criteria for TMJ arthroscopy and to determine whether there was a difference in outcomes between younger and older patients. MATERIALS AND METHODS: This was a retrospective chart review of patients who underwent TMJ operative arthroscopy. The primary variable studied was patient age...
November 9, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27906752/recent-developments-in-emerging-therapeutic-targets-of-osteoarthritis
#2
Margaret Man-Ger Sun, Frank Beier, Michael A Pest
PURPOSE OF REVIEW: Despite the tremendous individual suffering and socioeconomic burden caused by osteoarthritis, there are currently no effective disease-modifying treatment options. This is in part because of our incomplete understanding of osteoarthritis disease mechanism. This review summarizes recent developments in therapeutic targets identified from surgical animal models of osteoarthritis that provide novel insight into osteoarthritis pathology and possess potential for progression into preclinical studies...
January 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27906035/extracellular-vesicles-in-the-pathogenesis-of-rheumatoid-arthritis-and-osteoarthritis
#3
REVIEW
Joseph Withrow, Cameron Murphy, Yutao Liu, Monte Hunter, Sadanand Fulzele, Mark W Hamrick
Osteoarthritis (OA) and rheumatoid arthritis (RA) are both debilitating diseases that cause significant morbidity in the US population. Extracellular vesicles (EVs), including exosomes and microvesicles, are now recognized to play important roles in cell-to-cell communication by transporting various proteins, microRNAs (miRNAs), and mRNAs. EV-derived proteins and miRNAs impact cell viability and cell differentiation, and are likely to play a prominent role in the pathophysiology of both OA and RA. Some of the processes by which these membrane-bound vesicles can alter joint tissue include extracellular matrix degradation, cell-to-cell communication, modulation of inflammation, angiogenesis, and antigen presentation...
December 1, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27900509/conversion-of-hip-fusion-to-total-hip-arthroplasty-clinical-radiological-outcomes-and-complications-in-40-hips
#4
Mustafa Celiktas, Ozkan Kose, Adil Turan, Ferhat Guler, Cagri Ors, Emre Togrul
OBJECTIVE: The purpose of this retrospective study is to report the clinical and radiological outcome of total hip arthroplasty in patients with previous hip arthrodesis. PATIENTS AND METHODS: We retrospectively reviewed 28 (40 hips) prospectively followed patients in whom ankylosed hips were converted to total hip arthroplasty (THA) between 2010 and 2014 in our institution. The average age at the time of the conversion operation was 40.8 ± 9.8 years (range 24-62)...
November 29, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27894176/complications-and-short-term-outcomes-of-medial-opening-wedge-high-tibial-osteotomy-using-a-locking-plate-for-medial-osteoarthritis-of-the-knee
#5
Seung-Suk Seo, Ok-Gul Kim, Jin-Hyeok Seo, Do-Hoon Kim, Youn-Gu Kim, In-Seung Lee
Purpose: The purpose of this study was to investigate complications and radiologic and clinical outcomes of medial opening wedge high tibial osteotomy (MOWHTO) using a locking plate. Materials and Methods: This study reviewed 167 patients who were treated with MOWHTO using a locking plate from May 2012 to June 2014. Patients without complications were classified into group 1 and those with complications into group 2. Medical records, operative notes, and radiographs were retrospectively reviewed to identify complications...
December 1, 2016: Knee Surgery & related Research
https://www.readbyqxmd.com/read/27894173/open-wedge-high-tibial-osteotomy-and-combined-arthroscopic-surgery-in-severe-medial-osteoarthritis-and-varus-malalignment-minimum-5-year-results
#6
Moon-Jib Yoo, Yong-Eun Shin
Purpose: To evaluate the radiologic and functional outcomes of medial open wedge high tibial osteotomy (HTO) combined with arthroscopic procedure in patients with medial osteoarthritis. Materials and Methods: From June 1996 to March 2010, 26 patients (32 knees) who underwent medial open wedge osteotomy and arthroscopic operation for medial osteoarthritis were retrospectively reviewed. Measurements included hip-knee-ankle (HKA) angle, femorotibial angle, medial proximal tibial angle, posterior tibial slope angle, and Kellgren-Lawrence grade...
December 1, 2016: Knee Surgery & related Research
https://www.readbyqxmd.com/read/27890246/treatment-of-dynamic-scapholunate-instability-dissociation-contribution-of-arthroscopy
#7
C Mathoulin
Scapholunate (SL) ligament injuries generally result from trauma to an extended, supinated wrist, leading to chronic instability that progresses toward osteoarthritis. They can occur together with distal radius fracture. These injuries can be difficult to diagnose, especially early on. Treating chronic SL ligament injuries before the onset of osteoarthritis is still a challenge for surgeons. Until recently, the recommended treatments consisted of open SL ligament reconstruction or repair procedures that reduce pain and improve pinch strength but also lead to wrist stiffness...
December 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27886697/nonsurgical-management-of-osteoarthritis-knee-pain-in-the-older-adult
#8
REVIEW
Nora Taylor
Symptomatic knee osteoarthritis is a common complaint of many elderly patients in primary care offices. For those unable or unwilling to undergo knee replacement, the primary practitioners' understanding of the strengths and weaknesses of the available treatment modalities for pain relief is critical to successful in-office counseling and expectation management. Treatment requires a multimodal approach of nonpharmacologic and pharmacologic therapies to achieve a maximal clinical benefit. The focus of this review is on the nonsurgical options for treatment of knee osteoarthritis in patients aged 65 and older...
February 2017: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/27884418/heterotopic-ossification-prophylaxis-after-total-hip-arthroplasty-randomized-trial-of-400-vs-700-cgy
#9
Jane Z Liu, Nicholas B Frisch, Regina M Barden, Aaron G Rosenberg, Craig D Silverton, Jorge O Galante
BACKGROUND: Heterotopic ossification (HO) is a known complication following total hip arthroplasty. Radiation is an effective prophylaxis, but an optimal protocol has yet to be determined. We performed a randomized, double-blinded clinical trial in high-risk patients to determine the efficacy of 400 vs 700 cGy doses of radiation. METHODS: One hundred forty-seven patients undergoing total hip arthroplasty and at high risk for HO at an urban medical center were randomized to receive either a single 400 or 700 cGy dose of radiation postoperatively...
November 1, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27881864/mass-spectrometry-imaging-a-novel-technology-in-rheumatology
#10
REVIEW
Beatriz Rocha, Cristina Ruiz-Romero, Francisco J Blanco
Mass spectrometry imaging (MSI) is used to determine the relative abundance and spatial distribution of biomolecules such as peptides, proteins, lipids and other organic compounds in tissue sections by their molecular masses. This technique provides a sensitive and label-free approach for high-resolution imaging, and is currently used in an increasing number of biomedical applications such as biomarker discovery, tissue classification and drug monitoring. Owing to technological advances in the past 5 years in diverse MSI strategies, this technology is expected to become a standard tool in clinical practice and provides information complementary to that obtained using existing methods...
November 24, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27871993/msc-exosome-as-a-cell-free-msc-therapy-for-cartilage-regeneration-implications-for-osteoarthritis-treatment
#11
REVIEW
Wei Seong Toh, Ruenn Chai Lai, James Hoi Po Hui, Sai Kiang Lim
Mesenchymal stem cell (MSC) therapies have demonstrated efficacy in cartilage repair in animal and clinical studies. The efficacy of MSC-based therapies which was previously predicated on the chondrogenic potential of MSC is increasingly attributed to the paracrine secretion, particularly exosomes. Exosomes are thought to function primarily as intercellular communication vehicles to transfer bioactive lipids, nucleic acids (mRNAs and microRNAs) and proteins between cells to elicit biological responses in recipient cells...
November 18, 2016: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/27865814/obesity-and-the-role-of-bariatric-surgery-in-the-surgical-management-of-osteoarthritis-of-the-hip-and-knee-a-review-of-the-literature
#12
REVIEW
Bryan D Springer, Jonathan T Carter, Alexander S McLawhorn, Keith Scharf, Mitchell Roslin, Kara J Kallies, John M Morton, Shanu N Kothari
Obesity accelerates the development of osteoarthritis of the knee and hip by exerting deleterious effects on joints through both biomechanical and also systemic inflammatory changes. The objective of this review was to evaluate the impact of obesity on lower limb biomechanics and total joint arthroplasty outcomes, as well as weight changes after joint arthroplasty and the role of bariatric surgery among patients requiring joint arthroplasty. The currently published data indicate that weight loss increases swing time, stride length, gait speed, and lower extremity range of motion...
September 14, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27864563/a-replication-study-and-meta-analysis-of-mitochondrial-dna-variants-in-the-radiographic-progression-of-knee-osteoarthritis
#13
Mercedes Fernández-Moreno, Angel Soto-Hermida, María E Vázquez-Mosquera, Estefanía Cortés-Pereira, Sonia Pértega, Sara Relaño, Natividad Oreiro-Villar, Carlos Fernández-López, Francisco J Blanco, Ignacio Rego-Pérez
OBJECTIVE: To conduct a replication study and meta-analysis involving the study of mtDNA variants in the radiographic progression of OA in different cohorts worldwide, including Cohort Hip and Cohort Knee (CHECK), the OA Initiative and a cohort from Spain. METHODS: The influence of the haplogroups in the rate of radiographic progression at 96 months in 431 subjects from CHECK was assessed in terms of Kellgren and Lawrence (KL) grade. Progression was defined as a change from KL ⩾ 1 at baseline to any higher grade during the follow-up...
November 17, 2016: Rheumatology
https://www.readbyqxmd.com/read/27860218/treatment-effectiveness-and-fidelity-of-manual-therapy-to-the-knee-a-systematic-review-and-meta-analysis
#14
Paul Salamh, Chad Cook, Michael P Reiman, Charles Sheets
Manual therapy (MT) is a commonly used treatment for knee osteoarthritis (OA) but to date only one systematic review has explored its effectiveness. The purpos e of the present study was to perform a systematic review and meta-analysis of the literature, to determine the effectiveness and fidelity of studies using MT techniques in individuals with knee OA. Relevant studies were assessed for inclusion. Effectiveness was measured using effect sizes, and methodological bias and treatment fidelity were both explored...
November 18, 2016: Musculoskeletal Care
https://www.readbyqxmd.com/read/27859817/lncrnas-novel-players-in-intervertebral-disc-degeneration-and-osteoarthritis
#15
REVIEW
Wen-Kang Chen, Xiao-Hua Yu, Wei Yang, Cheng Wang, Wen-Si He, Yi-Guo Yan, Jian Zhang, Wen-Jun Wang
The term long non-coding RNA (lncRNA) refers to a group of RNAs with length more than 200 nucleotides, limited protein-coding potential, and having widespread biological functions, including regulation of transcriptional patterns and protein activity, formation of endogenous small interfering RNAs (siRNAs) and natural microRNA (miRNA) sponges. Intervertebral disc degeneration (IDD) and osteoarthritis (OA) are the most common chronic, prevalent and age-related degenerative musculoskeletal disorders. Numbers of lncRNAs are differentially expressed in human degenerative nucleus pulposus tissue and OA cartilage...
November 9, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27858928/are-intraarticular-steroids-effective-for-knee-osteoarthritis
#16
Jorge Faúndez, Petre Cotoras, Sebastián Irarrázaval
Knee osteoarthritis is a chronic disabling condition that is both progressive and irreversible. Intraarticular steroids are commonly used to reduce osteoarthritis symptoms and to minimize the need for surgery. Nevertheless, debate still exists regarding the efficacy and safety of steroids. To address this point, we searched Epistemonikos database which is maintained by screening 30 separate databases and identified 12 systematic reviews including 41 studies addressing steroids use in knee osteoarthritis. Of these, 40 were randomized trials...
November 11, 2016: Medwave
https://www.readbyqxmd.com/read/27857636/posterior-lateral-and-anterior-hip-pain-due-to-musculoskeletal-origin-a-narrative-literature-review-of-history-physical-examination-and-diagnostic-imaging
#17
REVIEW
Patrick J Battaglia, Kevin D'Angelo, Norman W Kettner
OBJECTIVE: The purpose of this study was to present a narrative review of the literature of musculoskeletal causes of adult hip pain, with special attention to history, physical examination, and diagnostic imaging. METHODS: A narrative review of the English medical literature was performed by using the search terms "hip pain" AND "anterior," "lateral," and "posterior." Additionally, specific entities of hip pain or pain referral sources to the hip were searched for...
December 2016: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/27852648/percutaneous-reduction-and-screw-fixation-of-displaced-intra-articular-fractures-of-the-calcaneus
#18
Saran Tantavisut, Phinit Phisitkul, Brian O Westerlind, Yubo Gao, Matthew D Karam, John L Marsh
BACKGROUND: Extensile open approaches to reduce and fix intra-articular calcaneal fractures are associated with high levels of wound complications. To avoid these complications, a technique of percutaneous reduction and fixation with screws alone was developed. This study assessed the clinical outcomes, radiographs, and postoperative CT scans after operative treatment with this technique. METHODS: 153 consecutive patients with 182 intra-articular calcaneal fractures were reviewed...
November 15, 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27849460/a-narrative-review-of-the-prevalence-and-risk-factors-associated-with-development-of-knee-osteoarthritis-after-traumatic-unilateral-lower-limb-amputation
#19
Shawn Farrokhi, Brittney Mazzone, Adam Yoder, Kristina Grant, Marilynn Wyatt
INTRODUCTION: Young military Service Members with traumatic unilateral lower limb amputations may be at a high risk for developing knee osteoarthritis (OA). There is growing evidence for potential influence and predictive value of nonsystemic risk factors on development and progression of primary knee OA in older adults. Proposed factors include chronic knee pain, obesity, abnormal knee joint mechanics, muscle weakness, previous knee trauma, and altered physical activity level. However, there is limited information available regarding whether such nonsystemic risk factors could also be responsible for the increased risk of knee OA after traumatic, unilateral lower limb amputation in young military Service Members...
November 2016: Military Medicine
https://www.readbyqxmd.com/read/27848219/the-valuation-of-informal-care-in-cost-of-illness-studies-a-systematic-review
#20
REVIEW
Juan Oliva-Moreno, Marta Trapero-Bertran, Luz Maria Peña-Longobardo, Raúl Del Pozo-Rubio
BACKGROUND: There is a growing interest in incorporating informal care in cost-of-illness studies as a relevant part of the economic impact of some diseases. OBJECTIVE: The aim of this paper was to review the recent literature valuating the costs of informal care in a group of selected diseases from 2005 to 2015. METHODS: We carried out a systematic review on the economic impact of informal care, focusing on six selected diseases: arthritis or osteoarthritis, cancer, dementia, mental diseases, multiple sclerosis and stroke...
November 15, 2016: PharmacoEconomics
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