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https://www.readbyqxmd.com/read/28328832/clinico-radiological-diagnosis-and-grading-of-rapidly-progressive-osteoarthritis-of-the-hip
#1
Ancuţa Zazgyva, Simona Gurzu, István Gergely, Ioan Jung, Ciprian O Roman, Tudor S Pop
Due to the current lack of standard definitions for rapidly progressive osteoarthritis of the hip (RPOH) in the literature, this observational study aimed to describe new diagnostic criteria and a grading system for the disease.From a consecutive series of patients undergoing total hip replacement, 2 groups were selected: 1 with RPOH and 1 with primary hip osteoarthritis (POH), and their clinical, paraclinical, and demographic data were compared. The newly proposed clinico-radiological diagnostic criteria are based on characteristics of pain, joint mobility, and radiological assessment...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28325502/systematic-review-of-cross-cultural-adaptations-of-hip-specific-patient-reported-outcome-measures-in-spanish
#2
Sara Gómez-Valero, Fernando García-Pérez, Mariano Tomás Flórez-García, Juan Carlos Miangolarra-Page
OBJECTIVE: The aim of this study was to conduct a systematic review of the quality of the transcultural adaptation procedure and the clinimetric properties of the self-administered hip-disability functional assessment questionnaires adapted for the Spanish population. MATERIAL AND METHOD: We searched the MEDLINE, EMBASE, CINAHL and Web of Science databases (from inception until June 2016) to locate all the scales adapted to Spanish and to analyze the different phases of the adaptation process and its psychometric properties...
March 16, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28323761/effect-of-land-based-generic-physical-activity-interventions-on-pain-physical-function-and-physical-performance-in-hip-and-knee-osteoarthritis-a-systematic-review-and-meta-analysis
#3
Shanelle Fernandopulle, Meredith Perry, Donald Manlapaz, Prasath Jayakaran
OBJECTIVE: The aim of this study was to evaluate the effects of land-based generic physical activity interventions on pain, physical function, and physical performance in individuals with hip/knee osteoarthritis, when compared with a control group that received no intervention, minimal intervention, or usual care. METHODS: A systematic search for randomized controlled trials on 11 electronic databases (from their inception up until April 30, 2016) identified 27 relevant articles...
March 18, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28322973/imidazoline-i2-receptors-an-update
#4
REVIEW
Jun-Xu Li
Since first introduced more than two decades ago, the research in imidazoline I2 receptors has been steadily increasing. This review provides an update on the current status of I2 receptor pharmacology. Imidazoline I2 receptors or I2 binding sites refer to several (at least four) different proteins that bind to [(3)H]-idazoxan and [(3)H]-2-BFI with high affinity. The molecular identities of the proteins remain elusive. One of the proteins (45 kD) seems to be consistent with the identity of brain creatine kinase...
March 16, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28321424/cell-based-meniscus-repair-and-regeneration-at-the-brink-of-clinical-translation-a-systematic-review-of-preclinical-studies
#5
Jasmijn V Korpershoek, Tommy S de Windt, Michella H Hagmeijer, Lucienne A Vonk, Daniel B F Saris
BACKGROUND: Meniscus damage can be caused by trauma or degeneration and is therefore common among patients of all ages. Repair or regeneration of the menisci could be of great importance not only for pain relief or regaining function but also to prevent degenerative disease and osteoarthritis. Current treatment does not offer consistent long-term improvement. Although preclinical research focusing on augmentation of meniscal tear repair and regeneration after meniscectomy is encouraging, clinical translation remains difficult...
February 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28320529/prevalence-of-neuropathic-pain-in-knee-or-hip-osteoarthritis-a-systematic-review-and-meta-analysis
#6
REVIEW
Helen P French, Keith M Smart, Frank Doyle
OBJECTIVE: Discordance between radiographic and pain severity in osteoarthritis (OA) has led researchers to investigate other pain mechanisms, including neuropathic pain. Accurate identification of any neuropathic pain in hip or knee OA is important for appropriate management, but neuropathic pain prevalence is unknown. We aimed to obtain an overall prevalence estimate by systematically reviewing and meta-analysing the prevalence of neuropathic pain in people with hip or knee OA. METHOD: Observational studies which measured neuropathic pain in people aged 18 years and older with hip or knee OA were considered for inclusion...
February 20, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28319426/high-satisfaction-and-return-to-sports-after-total-shoulder-arthroplasty-in-patients-aged-55-years-and-younger
#7
Grant H Garcia, Joseph N Liu, Alec Sinatro, Hao-Hua Wu, Joshua S Dines, Russell F Warren, David M Dines, Lawrence V Gulotta
BACKGROUND: Young, active candidates for total shoulder arthroplasty (TSA) are a unique group of patients. Not only do they demand longevity and improved function, but they also desire a return to physical activities. PURPOSE: To determine the rate of return to sports in patients aged ≤55 years undergoing TSA. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: This was a retrospective review of consecutive patients who underwent anatomic TSA at a single institution...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28319248/cyclic-tensile-strain-enhances-human-mesenchymal-stem-cell-smad-2-3-activation-and-tenogenic-differentiation-in-anisotropic-collagen-glycosaminoglycan-scaffolds
#8
W G Grier, A S Moy, B A Harley
Stem cell research arose from the need to explore new therapeutic possibilities for intractable and lethal diseases. Although musculoskeletal disorders are basically nonlethal, their high prevalence and relative ease of performing clinical trials have facilitated the clinical application of stem cells in this field. However, few reliable clinical studies have been published, despite the plethora of in vitro and preclinical studies in stem cell research for regenerative medicine in the musculoskeletal system...
March 20, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28318047/systems-approaches-in-osteoarthritis-identifying-routes-to-novel-diagnostic-and-therapeutic-strategies
#9
Alan J Mueller, Mandy J Peffers, Carole J Proctor, Peter D Clegg
Systems orientated research offers the possibility of identifying novel therapeutic targets and relevant diagnostic markers for complex diseases such as osteoarthritis. This review demonstrates that the osteoarthritis research community has been slow to incorporate systems orientated approaches into research studies, although a number of key studies reveal novel insights into the regulatory mechanisms that contribute both to joint tissue homeostasis and its dysfunction. The review introduces both top-down and bottom-up approaches employed in the study of osteoarthritis...
March 20, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28317389/prp-for-degenerative-cartilage-disease
#10
Lior Laver, Niv Marom, Lad Dnyanesh, Omer Mei-Dan, João Espregueira-Mendes, Alberto Gobbi
OBJECTIVE: To explore the utilization of platelet-rich plasma (PRP) for degenerative cartilage processes and evaluate whether there is sufficient evidence to better define its potential effects. DESIGN: Systematic literature reviews were conducted in PubMed/MEDLINE and Cochrane electronic databases till May 2015, using the keywords "platelet-rich plasma OR PRP OR autologous conditioned plasma OR ACP AND cartilage OR chondrocyte OR chondrogenesis OR osteoarthritis (OA) OR arthritis...
September 1, 2016: Cartilage
https://www.readbyqxmd.com/read/28306711/is-glucosamine-effective-for-osteoarthritis
#11
Stephanie Harrison-Muñoz, Valentina Rojas-Briones, Sebastián Irarrázaval
Osteoarthritis is the most prevalent chronic articular disease, in which pain is one of the main symptoms and a major determinant of functional loss. Several therapeutic options have been proposed, including glucosamine, but its actual usefulness has not yet been established. To answer this question, we searched in Epistemonikos database, which is maintained by screening multiple databases. We identified 11 systematic reviews including 35 randomized trials answering the question of interest. We extracted data, conducted a meta-analysis and generated a summary of findings table using the GRADE approach...
March 15, 2017: Medwave
https://www.readbyqxmd.com/read/28303458/calcitonin-gene-related-peptide-and-pain-a-systematic-review
#12
REVIEW
Wendy Sophie Schou, Sait Ashina, Faisal Mohammad Amin, Peter J Goadsby, Messoud Ashina
BACKGROUND: Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive pathways in human peripheral and central nervous system and its receptors are also expressed in pain pathways. CGRP is involved in migraine pathophysiology but its role in non-headache pain has not been clarified. METHODS: We performed a systematic literature search on PubMed, Embase and ClinicalTrials.gov for articles on CGRP and non-headache pain covering human studies including experimental studies and randomized clinical trials...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28291181/total-hip-arthroplasty-in-patients-with-cerebral-palsy-a-cohort-study-matched-to-patients-with-osteoarthritis
#13
Matthew T Houdek, Chad D Watts, Cody C Wyles, Robert T Trousdale, Todd A Milbrandt, Michael J Taunton
BACKGROUND: The spasticity and increased muscle tone observed in patients with cerebral palsy can lead to hip degeneration, subluxation, and pain. Currently, there is hesitation to perform total hip arthroplasty in patients with cerebral palsy because of fears of early wear and dislocation. The purpose of this study was to review the outcomes of total hip arthroplasty in patients with cerebral palsy and to compare outcomes with those of matched patients with a diagnosis of osteoarthritis...
March 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28289822/combined-anterior-cruciate-ligament-reconstruction-and-lateral-extra-articular-tenodesis-does-not-result-in-an-increased-rate-of-osteoarthritis-a-systematic-review-and-best-evidence-synthesis
#14
REVIEW
Brian M Devitt, Nicolas Bouguennec, Kristoffer W Barfod, Tabitha Porter, Kate E Webster, Julian A Feller
PURPOSE: The role of lateral extra-articular tenodesis (LEAT) as an augment to primary anterior cruciate ligament reconstruction (ACLR) remains controversial. However, concerns exist regarding the risk of development of osteoarthritis due to over constraint of the knee. To systematically review the literature to analyse the long-term incidence of osteoarthritis in patients who had an LEAT performed in isolation or in combination with intra-articular ACLR for the treatment of ACL deficiency...
March 13, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28288340/an-overview-of-hydrogel-based-intra-articular-drug-delivery-for-the-treatment-of-osteoarthritis
#15
REVIEW
Zhiwei He, Beiyue Wang, Changmin Hu, Jianning Zhao
Drug administration by intra-articular injection is an emerging popular treatment for knee osteoarthritis (OA). This method of drug administration minimizes the toxic effects of the drugs administered systemically, and maximizes local effects. However, traditional oral drugs delivered via intra-articular injection are limited by the lack of sustained release. Injectable materials such as hydrogels or hydrogel microspheres have been extensively studied for their applications as intra-articular injection for the treatment of OA, which is attribute to their minimally invasive manner, extended drug retention time and high loading efficiency...
March 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28288078/idiopathic-genu-valgum-and-its-association-with-obesity-in-children-and-adolescents
#16
Janet L Walker, Pooya Hosseinzadeh, Hank White, Kevin Murr, Todd A Milbrandt, Vishwas J Talwalkar, Henry Iwinski, Ryan Muchow
BACKGROUND: Obesity as a cause of lower extremity deformity in children has been well established. This deformity is most often seen as tibia vara, however, at our institution we have observed more obese children and adolescents over age 7 years with excessive or progressive idiopathic genu valgum. Our hypothesis is that children with idiopathic genu valgum have high rates of obesity which impact the severity of their disease. METHODS: Retrospective review of existing data was performed on 66 consecutive children/112 limbs over age 7 years with idiopathic genu valgum, seen from 2010 to 2013...
March 10, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28287489/review-of-prospects-of-biological-fluid-biomarkers-in-osteoarthritis
#17
REVIEW
Lich Thi Nguyen, Ashish Ranjan Sharma, Chiranjib Chakraborty, Balaji Saibaba, Moo-Eob Ahn, Sang-Soo Lee
Osteoarthritis (OA) is a degenerative disease of the joints and is one of the leading causes of disability in adults. However, there are no key therapeutics for OA and medical treatment is based on managing the symptoms and slowing down progression of the disease. Diagnostics based on clinical examination and radiography have provided little information about metabolic changes in joint tissues, disease onset and progression. Due to lack of effective methods for early detection and evaluation of treatment outcome, the measurement of biochemical markers (biomarkers) shows promise as a prospective method aiding in disease monitoring...
March 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28280641/prosthetic-joint-infection-due-to-mycobacterium-avium-intracellulare-in-a-patient-with-rheumatoid-arthritis-a-case-report-and-review-of-the-literature
#18
Nicholas E Ingraham, Brenton Schneider, Jonathan D Alpern
Nontuberculous mycobacteria (NTM) are a rare cause of prosthetic joint infections (PJI). However, the prevalence of NTM infections may be increasing with the rise of newer immunosuppressive medications such as biologics. In this case report, we describe a rare complication of immunosuppressive therapies and highlight the complexity of diagnosing and treating PJI due to NTM. The patient is a 79-year-old Caucasian male with a history of severe destructive rheumatoid arthritis on several immunosuppressive agents and right hip osteoarthritis s/p total hip arthroplasty 15 years previously with several complex revisions, presenting with several weeks of worsening right hip and abdominal pain...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28276651/realignment-surgery-for-malunited-ankle-fracture
#19
Chang-Jun Guo, Xing-Cheng Li, Mu Hu, Yang Xu, Xiang-Yang Xu
OBJECTIVE: To investigate the characteristics and the results of realignment surgery for the treatment of malunited ankle fracture. METHODS: Thirty-three patients with malunited fractures of the ankle who underwent reconstructive surgery at our hospital from January 2010 to January 2014 were reviewed. The tibial anterior surface angle (TAS), the tibiotalar tilt angle (TTA), the malleolar angle (MA), and the tibial lateral surface angle (TLS) were measured. Clinical assessment was performed with use of the American Orthopaedic Foot and Ankle Society (AOFAS) scale and visual analogue scale (VAS) scores, and the osteoarthritis stage was determined radiographically with the modified Takakura classification system...
March 9, 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28275210/phytomedicine-in-joint-disorders
#20
REVIEW
Dorin Dragos, Marilena Gilca, Laura Gaman, Adelina Vlad, Liviu Iosif, Irina Stoian, Olivera Lupescu
Chronic joint inflammatory disorders such as osteoarthritis and rheumatoid arthritis have in common an upsurge of inflammation, and oxidative stress, resulting in progressive histological alterations and disabling symptoms. Currently used conventional medication (ranging from pain-killers to biological agents) is potent, but frequently associated with serious, even life-threatening side effects. Used for millennia in traditional herbalism, medicinal plants are a promising alternative, with lower rate of adverse events and efficiency frequently comparable with that of conventional drugs...
January 16, 2017: Nutrients
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