keyword
MENU ▼
Read by QxMD icon Read
search

review + osteoarthritis

keyword
https://www.readbyqxmd.com/read/29222059/some-cochrane-risk-of-bias-items-are-not-important-in-osteoarthritis-trials-a-meta-epidemiological-study-based-on-cochrane-reviews
#1
REVIEW
Julie Bolvig, Carsten B Juhl, Isabelle Boutron, Peter Tugwell, Elizabeth A T Ghogomu, Jordi Pardo Pardo, Tamara Rader, George A Wells, Alain Mayhew, Lara Maxwell, Hans Lund, Henning Bliddal, Robin Christensen
OBJECTIVE: To evaluate the impact of bias-related study characteristics on treatment effects in osteoarthritis (OA) trials. STUDY DESIGN: Based on OA trials included in Cochrane reviews the impact of study characteristics on treatment effect estimates were evaluated. Characteristics included items of the risk of bias tool (RoB), trial size, single vs multi-site, and source of funding. Effect sizes were calculated as standardized mean differences (SMDs). Meta-regression was performed to identify "relevant study-level covariates" that decreases the between-study variance (τˆ2)...
December 5, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29222056/are-bisphosphonates-efficacious-in-knee-osteoarthritis-a-meta-analysis-of-randomized-controlled-trials
#2
Elizaveta E Vaysbrot, Mikala C Osani, Mia-Cara Musetti, Timothy E McAlindon, Raveendhara R Bannuru
OBJECTIVE: To clarify the effects of bisphosphonates in knee osteoarthritis (OA) using an up-to-date meta-analysis of randomized controlled trials (RCTs). DESIGN: The protocol is registered in PROSPERO (CRD42017073449). We searched MEDLINE, EMBASE, Google Scholar, Web of Science, and Cochrane Database from inception until August 2017. We included only RCTs comparing any bisphosphonates vs. placebo in knee OA patients and reporting validated pain and function scales, radiographic progression, and adverse events outcomes...
December 5, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29219021/review-of-the-mechanism-of-action-for-supartz-fx-in-knee-osteoarthritis
#3
Roy D Altman, Vinod Dasa, Jun Takeuchi
Objective Summarize the biologic effects of Supartz FX for knee osteoarthritis (OA), the first worldwide clinically approved intra-articular (IA) hyaluronic acid (HA) product. Design To determine the mechanism of action from preclinical and clinical studies, a literature search was conducted of Supartz FX using academic databases from 1987 to 2016. Articles on Supartz FX that deal with its mechanisms of action were extracted, categorized, and reviewed. Results Supartz FX has 2 potential mechanisms of action: (1) biomechanical: IA Supartz FX directly improves the viscoelasticity and lubrication of synovial fluid; (2) physiologic: IA Supartz FX penetrates synovium and cartilage tissues to reach HA receptors on the surface of synoviocytes and chondrocytes...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29218077/long-noncoding-rnas-a-new-regulatory-code-in-osteoarthritis
#4
REVIEW
Xiao Cen, Xin-Qi Huang, Wen-Tian Sun, Qing Liu, Jun Liu
It is reported that long noncoding RNAs (lncRNAs) were expressed aberrantly in cartilage of osteoarthritis (OA). Current evidence indicates that lncRNAs not only serve as positive or negative regulators of OA, but also crosstalk with multiple potential targets to impact on the critical events in OA process. This review summarized the lncRNAs identified in OA to date, discussed their influence on the survival of chondrocytes and synoviocytes, arthritis-associated factors, and angiogenesis, and indicated the potential in diagnosis, therapy, and prognosis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29214949/-a-review-on-psychosomatic-factors-affecting-the-outcome-after-total-knee-arthroplasty-tka
#5
Matthias Vogel, Christian Riediger, Sebastian Illiger, Jörg Frommer, Christoph H Lohmann
A review on psychosomatic factors affecting the outcome after total knee-arthroplasty (TKA) Objectives: In today's ageing Western societies, arthroplasty is a common treatment for endstage osteoarthritis. Despite highly developed implants and surgery, however, this treatment does not always succeed in relieving pain and restoring joint function, i.e., in restoring satisfactory algofunction. Clinicians partly blame psychological factors for this discrepancy, especially in the absence of objective medical complications...
December 2017: Zeitschrift Für Psychosomatische Medizin und Psychotherapie
https://www.readbyqxmd.com/read/29214143/the-potential-of-micrornas-for-stem-cell-based-therapy-for-degenerative-skeletal-diseases
#6
REVIEW
Emma Budd, Shona Waddell, María C de Andrés, Richard O C Oreffo
Purpose of Review: Degenerative skeletal disorders including osteoarthritis (OA) and osteoporosis (OP) are the result of attenuation of tissue regeneration and lead to painful conditions with limited treatment options. Preventative measures to limit the onset of OA and OP remain a significant unmet clinical need. MicroRNAs (miRNAs) are known to be involved in the differentiation of stem cells, and in combination with stem cell therapy could induce skeletal regeneration and potentially prevent OA and OP onset...
2017: Current Molecular Biology Reports
https://www.readbyqxmd.com/read/29212381/lowering-side-effects-of-nsaid-usage-in-osteoarthritis-recent-attempts-at-minimizing-dosage
#7
Kevin H Maniar, Ian A Jones, C Thomas Vangsness, Rayudu Gopalakrishna
Introduction Osteoarthritis is a burdensome disease that causes progressive damage to articular cartilage. Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the preferred treatments for symptomatic relief. However, NSAIDs can cause serious dose-dependent side effects, which has prompted experts to recommend the minimization of NSAID dosage. Areas Covered This review focuses on three broad strategies that are currently being investigated or implemented to minimize NSAID dosage: nano-formulation, encapsulation, and topical delivery...
December 7, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29210206/intra-articular-platelet-rich-plasma-injections-for-knee-osteoarthritis-an-overview-of-systematic-reviews-and-risk-of-bias-considerations
#8
Dan Xing, Bin Wang, Wei Zhang, Ziyi Yang, Yunfei Hou, Yaolong Chen, Jianhao Lin
OBJECTIVES: Numerous systematic reviews investigating the efficacy of platelet-rich plasma (PRP) in treating knee osteoarthritis (OA) have been recently published. The purpose of the present study was (1) to perform an overview of overlapping systematic reviews investigating PRP for knee OA via evaluating methodological quality and risk of bias of systematic reviews and (2) to provide recommendations through the best evidence. METHODS: A systematic search of systematic reviews published through Feb 2017 was conducted using the MEDLINE, EMBASE and Cochrane Library...
December 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29210022/trochleoplasty-procedures-show-complication-rates-similar-to-other-patellar-stabilizing-procedures
#9
Jordy D P van Sambeeck, Sebastiaan A W van de Groes, Nico Verdonschot, Gerjon Hannink
PURPOSE: Trochleoplasty aims to restore patellar stability. Various techniques have been described and almost all authors report successful results. However, the procedure has a significant risk of complications. Purpose of this study was to perform a systematic review and meta-analysis of the available literature to assess the rate of complications after the various techniques used for trochleoplasty procedures. MATERIALS AND METHODS: MEDLINE, EMBASE, Web of Science and Cochrane Library databases were searched...
December 5, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29208323/evaluation-of-posterior-cruciate-ligament-and-intercondylar-notch-in-subjects-with-anterior-cruciate-ligament-tear-a-comparative-flexed-knee-3d-magnetic-resonance-imaging-study
#10
Atul K Taneja, Frederico C Miranda, Marco K Demange, Marcelo P Prado, Durval C B Santos, Laercio A Rosemberg, Ronaldo H Baroni
PURPOSE: To determine if posterior cruciate ligament (PCL) and intercondylar notch (IN) morphometries and volumetrics act as risk factors for anterior cruciate ligament (ACL) tears. METHODS: A prospective case-controlled magnetic resonance imaging (MRI) study was conducted with subjects presenting noncontact knee injuries. Exclusion criteria were previous surgery, PCL tear, osteoarthritis, tumors, or infectious and inflammatory conditions. All participants underwent a flexed-knee 3-dimensional (3D) magnetic resonance imaging (MRI) to uniformly straighten PCL...
December 2, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29207792/clinical-evaluation-of-efficacy-and-performance-of-all-poly-tibial-freedom%C3%A2-total-knee-system-for-treating-osteoarthritis-patients-three-year-follow-up-study
#11
Avatar Singh, Kanwar Kulwinder Singh
Introduction: Advancement in technology in terms of design and building materials has made Total Knee Replacement (TKR) a highly effective, safe, and predictable orthopedic procedure. Aim: To review the clinical outcomes for efficacy and performance of Freedom Total Knee System for the management of Osteoarthritis (OA), at a minimum of three years follow up. Materials and Methods: For this retrospective, post-marketing study, clinical data of patients treated with Freedom Total Knee System was retrieved from the clinical records after approval from the Institutional Ethics Committee ...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29204703/an-intra-articular-synovial-lipoma-of-the-hip-possibly-causing-osteoarthritis-a-case-report-and-review-of-the-literature
#12
Sujin Kim, Geun Young Lee, Yong Chan Ha
In this report, we present the case of an intra-articular synovial lipoma in a 58-year-old female with a coincident marked unilateral hip osteoarthritis. This patient suffered from right hip pain that developed gradually over 2 years. Physical examination noted decreased range of motion and evidence of impingement. MR and CT images showed an intra-articular fat-intense mass in the hip joint that was excised and confirmed as a synovial lipoma on histology. This case reveals that an intra-articular lipoma of the hip could be accompanied by pain or impingement and followed by hip osteoarthritis even in the absence of trauma...
December 4, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29204582/publication-trends-in-obstructive-sleep-apnea-evidence-of-need-for-more-evidence
#13
R Araslanova, J Paradis, B W Rotenberg
Objective: Published research in obstructive sleep apnea (OSA) appears limited despite OSA being a highly prevalent adult and pediatric disease leading to many adverse outcomes if left untreated. We aimed to quantify the deficit in OSA scientific literature in order to provide a novel way of identifying gaps in knowledge and a need for further research inquiry. Methods: This was a Bibliometric analysis study. Using Ovid Medline database we analyzed and compared research output (medical and surgical) between adult OSA and similarly prevalent chronic conditions (Type II diabetes (T2DM), coronary artery disease (CAD) and osteoarthritis (OA)) from December 2016 up to fifty years prior...
June 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29203354/unicompartmental-knee-arthroplasty-vs-high-tibial-osteotomy-for-knee-osteoarthritis-a-systematic-review-and-meta-analysis
#14
ZhenWu Cao, XiuJun Mai, Jun Wang, EnHui Feng, YongMing Huang
BACKGROUND: Prior studies have compared unicompartmental knee arthroplasty (UKA) with high tibial osteotomy (HTO) suggesting that both procedures had good clinical outcomes. However, which treatment is more beneficial for unicompartmental knee osteoarthritis is still a controversy. The purpose of our study is to obtain postoperative outcomes of revision rate, complications, function results, range of motion (ROM), and pain between the 2 procedures. METHODS: Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were followed and study protocol was published online at PROSPERO under registration number CRD42016049316...
December 1, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29202618/synovial-fluid-proteomics-in-the-pursuit-of-arthritis-mediators-an-evolving-field-of-novel-biomarker-discovery
#15
Shalini M Mahendran, Katerina Oikonomopoulou, Eleftherios P Diamandis, Vinod Chandran
Synovial fluid (SF) is a protein-rich fluid produced into the joint cavity by cells of the synovial membrane. Due to its direct contact with articular cartilage, surfaces of the bone, and the synoviocytes of the inner membrane, it provides a promising reflection of the biochemical state of the joint under varying physiological and pathophysiological conditions. This property of SF has been exploited within numerous studies in search of unique biomarkers of joint pathologies with the ultimate goal of developing minimally invasive clinical assays to detect and/or monitor disease states...
December 4, 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29202567/the-use-of-hyaluronic-acid-in-the-treatment-of-ankle-osteoarthritis-a-review-of-the-evidence
#16
R Papalia, E Albo, F Russo, A Tecame, G Torre, S Sterzi, F Bressi, V Denaro
Ankle osteoarthritis (OA) is a progressive degenerative joint disease that causes ankle pain and functional limitation especially during walking. It tends to involve younger people with high functional request and has often a post-traumatic origin. Symptoms control through conservative treatment is essential to procrastinate as long as possible the need for surgery. Although few data are present in literature about the use of local viscosupplementation in ankle OA, their potential use for ankle OA has been suggested...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202562/intrarticular-injections-of-hyaluronic-acid-for-trapezio-metacarpal-osteoarthritis-a-systematic-review
#17
R Papalia, L A Diaz, G Torre, E Albo, A Tecame, S Sterzi, F Bressi, V Denaro
Osteoarthritis (OA) of the base of the thumb, also known as Trapezio-Metacarpal (TM) OA, is a disabling condition, which mainly affects women and manual workers. When TM OA is not adequately treated, patients develop deformity and loss of function of the thumb. The surgical approach is a widespread strategy to treat this condition, but there is still no consensus on the most effective procedure. Therefore, several conservative strategies are commonly used, such as nonsteroidal anti-inflammatory drugs (NSAIDs) administration, thumb strengthening exercise, splinting, steroid (CS) and hyaluronic acid (HA) intrarticular injections...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29202561/meniscal-extrusion-as-booster-of-osteoarthritis
#18
R Papalia, G Papalia, F Russo, L A Diaz, F Bressi, S Sterzi, V Denaro
Meniscal extrusion (ME) has shown to play a critical but still unclear role in osteoarthritis (OA) development. ME has been described as an important risk factor in the progression of knee OA, as it is involved in the thinning of articular cartilage, joint space narrowing, spontaneous osteonecrosis of the knee and subchondral bone marrow lesions. Meniscal damage of any degree of severity could cause ME in both compartments, but it is commonly associated with severe meniscal tears or root tears mainly in the medial meniscus...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29200484/treatment-of-femoroacetabular-impingement-with-a-mini-open-direct-anterior-approach
#19
Paweł Skowronek, Marek Synder, Michał Polguj, Dariusz Marczak, Marcin Sibiński
Background: The opinion about best methods of femoroacetabular impingement (FAI) treatment are not consistent. Operative treatment of this condition may be arthroscopic, but open procedures with osteotomy of the greater trochanter and hip dislocation has been used. The present study evaluates the benefits of the mini-open direct anterior approach (DAA) in treating patients with FAI, with is a procedure available for most orthopedic surgeons. Materials and Methods: 39 patients treated for FAI (25 men and 14 women) at an average age of 29...
November 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29199605/modeling-mesenchymal-stem-cells-in-tmj-rheumatoid-arthritis-and-osteoarthritis-therapy
#20
Nedime Serakinci, Gokce Savtekin
Stem cells have self-renewal capacity and an ability to differentiate into particular cell types generating mature cells. Mesenchymal stem cells (MSCs) have a significant role in tissue homeostasis, which leads into tissue regeneration. MSCs are rare pluripotent cells supporting hematopoietic and mesenchymal cell lineages. MSCs are also believed to have therapeutic power over temporomandibular joint (TMJ) disorders (TMDs). The most common type of TMD is articular disc displacement, which induces progressive degenerative changes...
2017: Critical Reviews in Eukaryotic Gene Expression
keyword
keyword
116799
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"