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https://www.readbyqxmd.com/read/29455473/comparison-between-magnetic-resonance-imaging-computed-tomography-and-arthrography-to-identify-artificially-induced-cartilage-defects-of-the-equine-carpal-joints
#1
José Suarez Sanchez-Andrade, Henning Richter, Karolin Kuhn, Andrea S Bischofberger, Patrick R Kircher, Séamus Hoey
While articular cartilage changes are considered to be one of the initial events in the pathological cascade leading to osteoarthritis, these changes remain difficult to detect using conventional diagnostic imaging modalities such as plain radiography. The aim of this prospective, experimental, methods comparison study was to compare the sensitivity of magnetic resonance imaging (MRI), magnetic resonance arthrography, computed tomography (CT), and CT arthrography in the detection of artificially induced articular cartilage defects in the equine carpal joints...
February 18, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29455165/community-deliverable-exercise-and-anxiety-in-adults-with-arthritis-and-other-rheumatic-diseases-a-systematic-review-with-meta-analysis-of-randomised-controlled-trials
#2
George A Kelley, Kristi S Kelley, Leigh F Callahan
BACKGROUND/PURPOSE: Given conflicting findings, the purpose of this study was to use the meta-analytic approach to examine the effects of exercise (aerobic, strength training or both) on anxiety in adults with arthritis and other rheumatic diseases (AORD). METHODS: Randomised controlled exercise intervention trials ≥4weeks in adults ≥18 years of age with osteoarthritis, rheumatoid arthritis or fibromyalgia were included. Studies were located by searching eight electronic databases, cross-referencing and expert review...
February 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29452304/the-chondrocyte-channelome-a-narrative-review
#3
Ali Mobasheri, Csaba Matta, Ilona Uzielienè, Emma Budd, Pablo Martín-Vasallo, Eiva Bernotiene
Chondrocytes are the main cells in the extracellular matrix of articular cartilage and possess a highly differentiated phenotype that is the hallmark of the unique physiological functions of this specialised load-bearing connective tissue. The plasma membrane of articular chondrocytes contains a rich and diverse complement of membrane proteins, known as the membranome, which defines the cell surface phenotype of the cells. The membranome is a key target of pharmacological agents and is important for chondrocyte function...
February 13, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29451138/detection-of-repair-of-the-zone-of-calcified-cartilage-with-osteoarthritis-through-mesenchymal-stem-cells-by-ultrashort-echo-time-magnetic-resonance-imaging
#4
REVIEW
Quan Zhou, Shao-Lin Li, Ya-Jun Ma, Vicki de Tal, Wei Li, Ying-Hua Zhao
Objective: Currently, magnetic resonance imaging (MRI) is the most commonly used imaging modality for observing the growth and development of mesenchymal stem cells (MSCs) after in vivo transplantation to treat osteoarthritis (OA). However, it is a challenge to accurately monitor the treatment effects of MSCs in the zone of calcified cartilage (ZCC) with OA. This is especially true in the physiological and biochemical views that are not accurately detected by MRI contrast agents. In contrast, ultrashort time echo (UTE) MRI has been shown to be sensitive to the presence of the ZCC, creating the potential for more effectively observing the repair of the ZCC in OA by MSCs...
February 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29451099/a-systematic-review-and-meta-analysis-of-arthroscopic-assisted-techniques-for-thumb-carpometacarpal-joint-osteoarthritis
#5
Suzanne C Wilkens, Claudia A Bargon, Amin Mohamadi, Neal C Chen, J Henk Coert
Arthroscopic management of thumb carpometacarpal (CMC) osteoarthrosis (OA) is an approach that has unclear results. We performed a systematic review encompassing three electronic databases up to May 2016 for studies describing arthroscopic-assisted techniques for thumb CMC OA. Meta-analyses of visual analogue scores (VAS) for pain, Disabilities of the Arm, Shoulder and Hand (DASH) scores, grip strength and pinch strength before and after arthroscopy were performed for ten included non-randomized cohort studies comprising 294 patients...
January 1, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29450666/recent-advances-in-hyaluronic-acid-based-therapy-for-osteoarthritis
#6
REVIEW
Steven Bowman, Mohamed E Awad, Mark W Hamrick, Monte Hunter, Sadanand Fulzele
Osteoarthritis is a debilitating disease that has increased in prevalence across the world due to the aging population. Currently, physicians use a plethora of treatment strategies to try and slow down the progression of the disease, but none have been shown to ubiquitously treat and cure the disease. One of the strategies uses the high molecular weight molecule hyaluronic acid as either an injectable or oral supplement for treatment. Hyaluronic acid (HA) is a relatively new treatment that has shown varied results through several clinical trials...
February 16, 2018: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/29446485/effects-of-glucosamine-supplements-on-painful-temporomandibular-joint-osteoarthritis-a-systematic-review
#7
REVIEW
Gilberto Melo, Elora Casett, Juliana Stuginski-Barbosa, Eliete Neves da Silva Guerra, Daniel Araujo Fernandes, André Luís Porporatti, Carlos Flores-Mir, Graziela De Luca Canto
OBJECTIVE: To systematically review the literature for studies that assessed the effects of glucosamine supplements (GS) on pain and maximum mouth opening (MMO) restriction compared to other therapies, placebo, or no intervention on painful temporomandibular joint osteoarthritis (TMJ OA). METHODS: Randomized controlled trials were selected in a two-phase process. Seven electronic databases, in addition to three grey literature databases, were searched. Risk of bias was assessed using the Cochrane Collaboration's tool for assessing risk of bias in randomized trials...
February 15, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29444323/the-role-of-fat-and-inflammation-in-the-pathogenesis-and-management-of-osteoarthritis
#8
Hema Urban, Christopher B Little
OA is a complex disease involving mechanical, metabolic and inflammatory contributions to its aetiology. A key risk factor, obesity, is becoming an increasing focus of research due to its multiple potential impacts on OA incidence, progression and symptom severity. An increased load due to an increase in body mass has been well established as a mechanical contribution to the pathophysiology of OA. However, evidence of obesity-linked to OA in non-weight-bearing joints has implicated the biological role of adipose inflammation and metabolic abnormalities in OA...
February 9, 2018: Rheumatology
https://www.readbyqxmd.com/read/29440159/multicentre-study-on-capsular-closure-versus-non-capsular-closure-during-hip-arthroscopy-in-danish-patients-with-femoroacetabular-impingement-fai-protocol-for-a-randomised-controlled-trial
#9
Christian Dippmann, Otto Kraemer, Bent Lund, Michael Krogsgaard, Per Hölmich, Martin Lind, Karen Briggs, Marc Philippon, Bjarne Mygind-Klavsen
INTRODUCTION: Hip arthroscopy has become a standard procedure in the treatment of hip joint pain not related to osteoarthritis or dysplasia in the young and active patient. There has been increasing focus on the contribution of the hip capsule to function and on stability following hip arthroscopy. It has been suggested that capsular closure after hip arthroscopy may prevent microinstability and macroinstability of the hip joint and reduce revision rate. However, it remains unknown whether capsular closure should be performed as a standard procedure when performing hip arthroscopies, especially in patients without additional risk factors for instability such as hypermobility or dysplasia of the hip...
February 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29438127/osteoarthritis-pain-recent-advances-and-controversies
#10
Hans-Georg Schaible
PURPOSE OF REVIEW: Osteoarthritis is one of the most frequent causes of chronic pain. Because there is no causal treatment of osteoarthritis, sufficient pain control is of uppermost importance but often not met. The review reports recent advances and controversies in our understanding of osteoarthritis pain and its treatment. RECENT FINDINGS: Osteoarthritis pain is determined by processes at different levels. An important local factor of pain generation in the joint is inflammation such as synovitis, and neuropathic components of osteoarthritis pain are being discussed...
February 12, 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29436380/relative-efficacy-and-safety-of-topical-non-steroidal-anti-inflammatory-drugs-for-osteoarthritis-a-systematic-review-and-network-meta-analysis-of-randomised-controlled-trials-and-observational-studies
#11
REVIEW
Chao Zeng, Jie Wei, Monica S M Persson, Aliya Sarmanova, Michael Doherty, Dongxing Xie, YiLun Wang, Xiaoxiao Li, Jiatian Li, Huizhong Long, Guanghua Lei, Weiya Zhang
OBJECTIVES: To compare the efficacy and safety of topical non-steroidal anti-inflammatory drugs (NSAIDs), including salicylate, for the treatment of osteoarthritis (OA). METHODS: PubMed, Embase, Cochrane Library and Web of Science were searched from 1966 to January 2017. Randomised controlled trials (RCTs) comparing topical NSAIDs with placebo or each other in patients with OA and observational studies comparing topical NSAIDs with no treatment or each other irrespective of disease were included...
February 7, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29434606/macrophage-recognition-of-crystals-and-nanoparticles
#12
REVIEW
Masafumi Nakayama
Inhalation of exogenous crystals such as silica, asbestos, and carbon nanotubes can cause lung fibrosis and cancer. Endogenous crystals such as monosodium urate, cholesterol, and hydroxyapatite are associated with pathogenesis of gout, atherosclerosis, and osteoarthritis, respectively. These crystal-associated-inflammatory diseases are triggered by the macrophage NLRP3 inflammasome activation and cell death. Therefore, it is important to understand how macrophages recognize crystals. However, it is unlikely that macrophages have evolutionally acquired receptors specific for crystals or recently emerged nanoparticles...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29430490/does-a-previous-high-tibial-osteotomy-hto-influence-the-long-term-function-or-survival-of-a-total-knee-arthroplasty-tka
#13
REVIEW
E Carlos Rodriguez-Merchan
High tibial osteotomy (HTO) is a well established technique for the treatment of medial osteoarthritis of the knee with varus malalignment. The outcome of total knee arthroplasty (TKA) after HTO remains uncertain. The aim of this paper is to revise the literature with the aim of answering the following question: Does a previous (HTO) influence the long-term function or survival of a TKA?. The search engine was MedLine. The keywords used were: total knee arthroplasty after high tibial osteotomy. One hundred and ten articles were found...
January 2018: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29429391/comparative-effectiveness-of-oral-pharmacologic-interventions-for-knee-osteoarthritis-a-network-meta-analysis
#14
Sun-Young Jung, Eun Jin Jang, Seoung Wan Nam, Hyuk Hee Kwon, Seul Gi Im, Dam Kim, Soo-Kyung Cho, Dalho Kim, Yoon-Kyoung Sung
OBJECTIVES: To explore the relative efficacy of oral pharmacologic interventions in the treatment of knee OA. METHODS: A systematic literature review was conducted using the MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials databases to identify trials conducted in patients with knee OA with a minimum 6 weeks of follow-up. The standardized mean differences of the change from baseline to week 6 in Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain between the treatment groups were estimated using Bayesian random-effects network meta-analyses...
February 12, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29429372/anti-inflammatory-effects-of-intra-articular-hyaluronic-acid-a-systematic-review
#15
Roy Altman, Asheesh Bedi, Ajay Manjoo, Faizan Niazi, Peter Shaw, Philip Mease
Objective Osteoarthritis (OA) is one of the leading causes of disability in the adult population. Common nonoperative treatment options include nonsteroidal anti-inflammatory drugs (NSAIDs), intra-articular corticosteroids, and intra-articular injections of hyaluronic acid (HA). HA is found intrinsically within the knee joint providing viscoelastic properties to the synovial fluid. HA therapy provides anti-inflammatory relief through a number of different pathways, including the suppression of pro-inflammatory cytokines and chemokines...
February 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29428553/radiocarpal-dislocations-and-fracture-dislocations-injury-types-and-long-term-outcomes
#16
C Spiry, G Bacle, E Marteau, B Charruau, J Laulan
INTRODUCTION: . Radiocarpal dislocation (RCD) and fracture-dislocations (RCFD) are severe but rare injuries for which the treatment and outcomes are not well defined. The aim of this retrospective study was to describe the prevalence of the various injury types and their long-term outcomes. PATIENTS AND METHODS: Between 1992 and 2014, 41 patients with RCFD were seen at our institution. According to the Dumontier classification, there were 4 cases of type 1 and 37 cases of type 2...
February 8, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29427723/intra-articular-injection-of-mesenchymal-stem-cells-in-treating-knee-osteoarthritis-a-systematic-review-of-animal-studies
#17
Dan Xing, Joey Kwong, Ziyi Yang, Yunfei Hou, Wei Zhang, Bin Ma, Jianhao Lin
PURPOSE: Mesenchymal stem cells (MSCs) injection has emerged as a novel treatment for knee osteoarthritis (KOA) but with inconsistent results in the experimental studies. Thus, the purpose of the present study is to evaluate the preclinical animal studies of MSCs injection for KOA and to determine the evidence for a role for MSCs in further clinical trials. METHODS: A systematic search of KOA animal studies published through Aug 2017 was conducted using the PubMed, EMBASE and web of science...
February 7, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29426009/clinimetrics-of-ultrasound-pathologies-in-osteoarthritis-systematicliterature-review-and-meta-analysis
#18
REVIEW
Win Min Oo, James M Linklater, Matthew Daniel, Simo Saarakkala, Jonathan Samuels, Philip G Conaghan, Helen I Keen, Leticia A Deveza, David J Hunter
OBJECTIVE: The aims of this study were to systematically review clinimetrics of commonly assessed ultrasound pathologies in knee, hip and hand osteoarthritis (OA), and to conduct a meta-analysis for each clinimetric. METHODS: MEDLINE, EMBASE, and Cochrane Library databases were searched from their inceptions to September 2016. According to the OMERACT Instrument Selection Algorithm, data extraction focused on ultrasound technical features and performance metrics...
February 6, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29425696/the-pericellular-hyaluronan-of-articular-chondrocytes
#19
REVIEW
Warren Knudson, Shinya Ishizuka, Kenya Terabe, Emily B Askew, Cheryl B Knudson
The story of hyaluronan in articular cartilage, pericellular hyaluronan in particular, essentially is also the story of aggrecan. Without properly tethered aggrecan, the load bearing function of cartilage is compromised. The anchorage of aggrecan to the cell surface only occurs due to the binding of aggrecan to hyaluronan-with hyaluronan tethered either to a hyaluronan synthase or by multivalent binding to CD44. In this review, details of hyaluronan synthesis are discussed including how HAS2 production of hyaluronan is necessary for normal chondrocyte development and matrix assembly, how an abundance or deficit of pericellular hyaluronan alters chondrocyte metabolism, and whether hyaluronan size matters or changes with aging or disease...
February 6, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29423330/mtor-signaling-in-skeletal-development-and-disease
#20
Jianquan Chen, Fanxin Long
The mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that integrates inputs from nutrients and growth factors to control many fundamental cellular processes through two distinct protein complexes mTORC1 and mTORC2. Recent mouse genetic studies have established that mTOR pathways play important roles in regulating multiple aspects of skeletal development and homeostasis. In addition, mTORC1 has emerged as a common effector mediating the bone anabolic effect of Igf1, Wnt and Bmp...
2018: Bone Research
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