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https://www.readbyqxmd.com/read/29049177/association-of-bmp-14-rs143383-ploymorphism-with-its-susceptibility-to-osteoarthritis-a-meta-analysis-and-systematic-review-according-to-prisma-guideline
#1
Yi Yin, Yan Wang
BACKGROUND: Osteoarthritis (OA) is a complex disease which can be caused by both environmental and genetic factors. A functional locus rs143383 of bone morphogenetic protein-14 (BMP-14) has been pointed out to be associated with OA etiology, but conflicting conclusions have been reached. To provide a more comprehensive conclusion about this issue, we performed this meta-analysis. METHODS: Relevant studies were searched from electronic databases including PubMed, Chinese National Knowledge Infrastructure, Embase, and Wanfang...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048690/large-fresh-osteochondral-allografts-for-the-hip-growing-the-evidence
#2
Lasun O Oladeji, James L Cook, James P Stannard, Brett D Crist
INTRODUCTION: Articular cartilage lesions of the hip are difficult to effectively treat. Osteochondral allograft (OCA) transplantation in the knee has been associated with long-term success, but OCA for the hip has not been extensively studied. Here, we present the clinical and radiological outcomes from a cohort of 10 patients treated with fresh OCA transplants for large osteochondral defects of the femoral head and/or acetabulum. METHODS: 10 patients who had undergone osteochondral allograft transplantation of the femoral head and/or acetabulum at our institution between 2013 and 2016 were identified from our Institutional Review Board-approved registry...
October 17, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29044993/intra-articular-hyaluronic-acid-injection-in-treating-knee-osteoarthritis-assessing-risk-of-bias-in-systematic-reviews-with-robis-tool
#3
Dan Xing, Bin Wang, Wei Zhang, Ziyi Yang, Yunfei Hou, Yaolong Chen, Jianhao Lin
OBJECTIVES: Intra-articular injection of hyaluronic acid (HA) is a common, yet controversial therapeutic option in treating knee osteoarthritis (OA). The purpose of the present study was to assess the risk of bias (RoB) of systematic reviews (SRs) and to summarize available evidence of HA in treating knee OA. METHODS: A systematic search of SRs published through to December 2016 was conducted using the MEDLINE, EMBASE and Cochrane Library. The RoB of included SRs was assessed by ROBIS tool...
October 17, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29040157/development-and-use-of-biochemical-markers-in-osteoarthritis-current-update
#4
Anne C Bay-Jensen, Christian S Thudium, Ali Mobasheri
PURPOSE OF REVIEW: There is an increasing demand for noninvasive and descriptive biochemical markers (biomarkers) in osteoarthritis; for enabling early drug development (including translational research), evaluating clinical trial at an early stage and for subtyping. Purpose of the review is to review and comment on current availability of such biomarkers. RECENT FINDINGS: Many different biomarkers have been tested in the last 18 months. The main focus has been on testing whether the biomarkers, whether is reflect joint tissue turnover or inflammatory status, can differentiate osteoarthritis patients from healthy controls or whether the biomarkers are associated with progression...
October 16, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29035932/extracellular-vesicles-in-cartilage-homeostasis-and-osteoarthritis
#5
Shigeru Miyaki, Martin K Lotz
PURPOSE OF REVIEW: Extracellular vesicles carry bioactive molecules that can be transferred between cells and tissues. The purpose of this review is to describe how extracellular vesicles regulate functions of cells in cartilage and other joint tissues. The potential application of extracellular vesicles in the treatment of osteoarthritis and as biomarkers will also be discussed. RECENT FINDINGS: Extracellular vesicles are found in synovial fluid, in articular cartilage and in the supernatants of synoviocytes and chondrocytes...
October 13, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29035928/what-did-we-learn-from-omics-studies-in-osteoarthritis
#6
Cristina Ruiz-Romero, Ignacio Rego-Perez, Francisco J Blanco
PURPOSE OF REVIEW: 'Omics' technologies developed for the massive analysis of the major biologically relevant molecules (genes, proteins, metabolites) have been applied to the study of osteoarthritis (OA) for more than a decade. RECENT FINDINGS: 'Omics' studies have undoubtedly contributed to increase the knowledge on pathogenic processes related with OA and have provided hundreds to thousands of molecules that might have a putative biomarker utility for this disease...
October 13, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29033157/midterm-survivorship-after-revision-total-hip-arthroplasty-with-a-custom-triflange-acetabular-component
#7
Brian P Gladnick, Keith A Fehring, Susan M Odum, Michael J Christie, David K DeBoer, Thomas K Fehring
BACKGROUND: Custom triflange acetabular components are being increasingly used for the reconstruction of Paprosky type IIIB acetabular defects. However, midterm survivorship data are lacking. METHODS: We queried the prospective registries at 2 high-volume revision centers for patients who had undergone revision total hip arthroplasty using a custom triflange component between 2000 and 2011. We identified 73 patients with minimum 5-year follow-up. These patients' records were reviewed to determine incidence of revision or reoperation, clinical performance, and radiographic stability...
September 21, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29033153/clinical-outcomes-and-survivorship-of-lateral-unicompartmental-knee-arthroplasty-does-surgical-approach-matter
#8
Tori A Edmiston, Gregory C Manista, P Maxwell Courtney, Scott M Sporer, Craig J Della Valle, Brett R Levine
BACKGROUND: Lateral unicompartmental knee arthroplasty (UKA) has been shown to be an effective procedure to treat isolated lateral compartment osteoarthritis with excellent long-term survivorship. Whether a medial parapatellar approach or a lateral parapatellar approach is superior in lateral UKA is unknown. The purpose of this study was to determine if there is a difference in intermediate-term clinical outcomes in patients undergoing lateral UKA through a lateral vs medial parapatellar approach...
September 21, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29032890/-identification-of-health-outcome-indicators-in-primary-care-a-review-of-systematic-reviews
#9
A Olry de Labry Lima, L García Mochón, C Bermúdez Tamayo
INTRODUCTION: Outcome measures are being widely used by health services to assess the quality of health care. It is important to have a battery of useful performance indicators with high validity and feasibility. Thus, the objective of this study is to perform a review of reviews in order to identify outcome indicators for use in Primary Care. METHODOLOGY: A review of systematic reviews (umbrella review) was carried out. The following databases were consulted: MedLine, EMBASE, and CINAHL, using descriptors and free terms, limiting searches to documents published in English or Spanish...
October 9, 2017: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
https://www.readbyqxmd.com/read/29032354/exercise-for-hand-osteoarthritis-a-cochrane-systematic-review
#10
Nina Østerås, Ingvild Kjeken, Geir Smedslund, Rikke H Moe, Barbara Slatkowsky-Christensen, Till Uhlig, Kåre Birger Hagen
OBJECTIVE: To assess the benefits and harms of exercise compared with other interventions, including placebo or no intervention, in people with hand osteoarthritis (OA). METHODS: Systematic review using Cochrane Collaboration methodology. Six electronic databases were searched up until September 2015. INCLUSION CRITERIA: randomized or controlled clinical trials comparing therapeutic exercise versus no exercise, or comparing different exercise programs...
October 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29031344/clinical-considerations-for-the-use-lower-extremity-arthroplasty-in-the-elderly
#11
REVIEW
Antonio Otero-López, David Beaton-Comulada
There is an increase in the aging population that has led to a surge of reported cases of osteoarthritis and a greater demand for lower extremity arthroplasty. This article aims to review the current treatment options and expectations when considering lower extremity arthroplasty in the elderly patient with an emphasis on the following subjects: (1) updated clinical guidelines for the management of osteoarthritis in the lower extremity, (2) comorbidities and risk factors in the surgical patient, (3) preoperative evaluation and optimization of the surgical patient, (4) surgical approach and implant selection, and (5) rehabilitation and life after lower extremity arthroplasty...
November 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/29030653/lateral-unicompartmental-knee-replacement-a-systematic-review-of-reasons-for-failure
#12
REVIEW
Lukas Ernstbrunner, Mohamed A Imam, Octavian Andronic, Tabea Perz, Karl Wieser, Sandro F Fucentese
PURPOSE: Currently, individual studies lack the power to successively illustrate different failure modes; therefore, we undertook a systematic review to examine lateral unicompartmental knee replacement (lat UKR) failure modes. Furthermore, we compared early with midterm and late failures and fixed-bearing with mobile-bearing implants. METHODS: A search using the databases of PubMed, EMBASE, Cochrane, and annual registries was performed to search for failed lat UKRs...
October 13, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29030413/patient-reported-outcome-measures-for-patients-with-meniscal-tears-a-systematic-review-of-measurement-properties-and-evaluation-with-the-cosmin-checklist
#13
Simon Gf Abram, Robert Middleton, David J Beard, Andrew J Price, Sally Hopewell
OBJECTIVE: Meniscal tears occur frequently in the population and the most common surgical treatment, arthroscopic partial meniscectomy, is performed in approximately two million cases worldwide each year. The purpose of this systematic review is to summarise and critically appraise the evidence for the use of patient-reported outcome measures (PROMs) in patients with meniscal tears. DESIGN: A systematic review was undertaken. Data on reported measurement properties were extracted and the quality of the studies appraised according to Consensus-based Standards for the Selection of Health Measurement Instruments...
October 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/29028791/is-diacerein-an-alternative-for-the-treatment-of-osteoarthritis
#14
Anselmo Alegría, Sebastián Irarrázaval
INTRODUCTION: Among the possibilities for the management of osteoarthritis, different pharmacological alternatives have been proposed, being diacerein one of them due to its anti-inflammatory effect. However, diacerein clinical utility is not clear. METHODS: To answer this question, we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others...
October 12, 2017: Medwave
https://www.readbyqxmd.com/read/29027192/hip-resurfacing-arthroplasty-for-patients-with-inflammatory-arthritis-a-systematic-review
#15
Kyle W Morse, Edwin P Su
INTRODUCTION: Modern metal-on-metal hip resurfacing arthroplasty has led to decreased revision rates and high implant survival rates as compared to prior generations of resurfacing. Many of the series that report on resurfacing outcomes focus upon patients treated with a diagnosis of osteoarthritis. Patients with inflammatory arthritis such as rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are also treated in these series, however, their outcomes following resurfacing are underreported...
October 12, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29025215/regenerative-cells-for-the-management-of-osteoarthritis-and-joint-disorders-a-concise-literature-review
#16
Travis J Block, Jaime R Garza
As the global population ages, the prevalence of osteoarthritis (OA) and joint disorders represent a major cause of disability and a significant public health burden. As current approaches for the management of OA focus on slowing the progression of disease, without repairing the underlying damage, novel treatments are necessary to improve outcomes. Over the past decade, autologous cell-based therapies using regenerative cells from fat or bone marrow have become a major focus of research into new approaches for the treatment of osteoarthritis and joint disorders...
July 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29021569/cushioning-the-cartilage-a-canonical-wnt-restricting-matter
#17
REVIEW
Silvia Monteagudo, Rik J Lories
Wnt signalling pathways have key roles in joint development, homeostasis and disease, particularly in osteoarthritis. New data is starting to reveal the importance of tightly regulating canonical Wnt signalling pathway activation to maintain homeostasis and health in articular cartilage. In addition to the presence of different Wnt antagonists that limit pathway activation in articular cartilage, the reciprocal crosstalk between the canonical and non-canonical cascades and competitive antagonism between different Wnt ligands seem to be critical in restraining excessive Wnt pathway activation...
October 12, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29020891/biologic-joint-repair-strategies-the-mizzou-biojoint-story
#18
Keiichi Kuroki, Aaron M Stoker, James P Stannard, Chantelle C Bozynski, Cristi R Cook, Ferris M Pfeiffer, James L Cook
Because articular cartilage has very limited healing potential, most symptomatic cartilage injuries eventually result in end-stage osteoarthritis and are treated with artificial joint replacement. Our interdisciplinary, comparative orthopedic research performed by a team of DVMs, MDs, engineers, and basic scientists has yielded marked progress toward effective biologic joint restoration strategies by bringing bench-side ideas to fruition in bedside applications in both canine and human patients. This mini-review summarizes the progress of biologic joint restoration strategies at our center...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/29020880/pulsed-electromagnetic-fields-and-tissue-engineering-of-the-joints
#19
Kenjiro Iwasa, Reddi A Hari
BACKGROUND: Bone and cartilage joint formation, maintenance and regeneration are regulated by both chemical and physical signals. Among the physical signals there is increasing realization of the role of Pulsed electromagnetic fields (PEMF) in the treatment of nonunions of bone fractures. The discovery of the piezoelectric properties of bone by Fukada and Yasuda in 1953 in Japan established the foundation of this field. Pioneering research by Bassett and Brighton and their teams resulted in the approval by Food and Drug Administration (FDA) the use of PEMF in treatment of fracture healing...
October 12, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29018060/dietary-supplements-for-treating-osteoarthritis-a-systematic-review-and-meta-analysis
#20
REVIEW
Xiaoqian Liu, Gustavo C Machado, Jillian P Eyles, Varshini Ravi, David J Hunter
OBJECTIVE: To investigate the efficacy and safety of dietary supplements for patients with osteoarthritis. DESIGN: An intervention systematic review with random effects meta-analysis and meta-regression. DATA SOURCES: MEDLINE, EMBASE, Cochrane Register of Controlled Trials, Allied and Complementary Medicine and Cumulative Index to Nursing and Allied Health Literature were searched from inception to April 2017. STUDY ELIGIBILITY CRITERIA: Randomised controlled trials comparing oral supplements with placebo for hand, hip or knee osteoarthritis...
October 10, 2017: British Journal of Sports Medicine
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