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https://www.readbyqxmd.com/read/29691754/the-effect-of-total-hip-arthroplasty-on-sports-and-work-participation-a-systematic-review-and-meta-analysis
#1
REVIEW
Alexander Hoorntje, Kim Y Janssen, Stefan B T Bolder, Koen L M Koenraadt, Joost G Daams, Leendert Blankevoort, Gino M M J Kerkhoffs, P Paul F M Kuijer
BACKGROUND: Total hip arthroplasty (THA) is a successful procedure to treat end-stage hip osteoarthritis. The procedure is increasingly performed in adults of working age, who often wish to return to sports (RTS) and return to work (RTW). However, a systematic overview of the evidence on RTS and RTW after THA is lacking. OBJECTIVES: Our aim was to systematically review (1) the extent to which patients RTS and RTW after THA, including (2) the time to RTS and RTW...
April 24, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29691165/acetabular-focal-chondral-lesions-are-not-associated-with-worse-outcomes-after-periacetabular-osteotomy-a-matched-group-analyses
#2
Michael D Hellman, Jeffery J Nepple, Cecilia Pascual-Garrido, Rafael J Sierra, John C Clohisy
BACKGROUND: The purpose of this study was to assess the outcomes of patients who underwent combined hip arthroscopy and periacetabular osteotomy with acetabular focal chondral defects and compare these outcomes with a group of patients without focal chondral defects. METHODS: A retrospective review looking at patients who underwent hip arthroscopy and/or periacetabular osteotomy was performed. Minimum 2-year follow-up, Tönnis grade 0-1, and a Beck chondromalacia stages 4-5 were included...
March 14, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29688827/efficacy-of-high-intensity-laser-therapy-in-treating-knee-osteoarthritis-a-first-systematic-review
#3
Justyna Wyszyńska, Monika Bal-Bocheńska
OBJECTIVE: The aim of this study was to evaluate the efficacy of high-intensity laser therapy (HILT) in the treatment of knee osteoarthritis (OA). BACKGROUND: Due to increased number of randomized controlled trials evaluating efficiency of HILT in patients with knee OA, there was a need to present them in the form of systematic review. METHODS: The search includes the databases as well as a manual search until August, 2017. The quality of the selected articles was determined in accordance with the revised guidelines of the CONSORT statement...
April 24, 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29685524/medial-meniscal-extrusion-detection-evaluation-and-clinical-implications
#4
REVIEW
Nayanatara Swamy, Vibhor Wadhwa, Gitanjali Bajaj, Avneesh Chhabra, Tarun Pandey
The menisci play an important role in knee kinematics. Their unique anatomy allows them to channel forces generated during knee movements through the larger tibio-femoral condylar surfaces while simultaneously resisting deleterious hoop stresses. Although physiologic meniscal extrusion occurs with every knee joint movement, pathologic meniscal extrusion subjects the knee to persistent and excessive load transmission. This renders the knee structures susceptible to injury or exacerbates worsening of existing knee joint internal derangement...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29684218/what-is-the-evidence-for-a-role-for-diet-and-nutrition-in-osteoarthritis
#5
Sally Thomas, Heather Browne, Ali Mobasheri, Margaret P Rayman
As current treatment options in OA are very limited, OA patients would benefit greatly from some ability to self-manage their condition. Since diet may potentially affect OA, we reviewed the literature on the relationship between nutrition and OA risk or progression, aiming to provide guidance for clinicians. For overweight/obese patients, weight reduction, ideally incorporating exercise, is paramount. The association between metabolic syndrome, type-2 diabetes and OA risk or progression may partly explain the apparent benefit of dietary-lipid modification resulting from increased consumption of long-chain omega-3 fatty-acids from oily fish/fish oil supplements...
May 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29683803/is-cemented-or-cementless-femoral-stem-fixation-more-durable-in-patients-older-than-75-years-of-age-a-comparison-of-the-best-performing-stems
#6
Michael Tanzer, Stephen E Graves, Andrea Peng, Andrew J Shimmin
BACKGROUND: There is ongoing debate concerning the best method of femoral fixation in older patients receiving primary THA. Clinical studies have shown high survivorship for cemented and cementless femoral stems. Arthroplasty registry studies, however, have universally shown that cementless stems are associated with a higher rate of revision in this patient population. It is unclear if the difference in revision rate is a reflection of the range of implants being used for these procedures rather than the mode of fixation...
April 9, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29682329/active-discopathy-a-clinical-reality
#7
REVIEW
Margaux Boisson, Marie-Martine Lefèvre-Colau, François Rannou, Christelle Nguyen
In the late 1980s, the description by Modic and colleagues of elementary discovertebral changes detected on MRI (Modic classification) suggested for the first time a possible correlation between anatomical and clinical features in a subgroup of patients with non-specific chronic low back pain. Degenerative disc disease is frequent and usually asymptomatic, but Modic 1 changes in the vertebral endplates adjacent to a degenerated disc are associated with inflammatory-like chronic low back pain and low-grade local and systemic inflammation, which led to the concept of 'active discopathy'...
2018: RMD Open
https://www.readbyqxmd.com/read/29682093/dna-methylation-in-osteoarthritis-current-status-and-therapeutic-implications
#8
REVIEW
Antonio Miranda-Duarte
Background: Primary Osteoarthritis (OA) is a multifactorial disease in which genetic factors are strongly associated with its development; however, recently it has been observed that epigenetic modifications are also involved in the pathogenesis of OA. DNA methylation is related to gene silencing, and several studies have investigated its role in the loci of different pathways or molecules associated to OA. Objective: This review is focused on the current status of DNA methylation studies related to OA pathogenesis...
2018: Open Rheumatology Journal
https://www.readbyqxmd.com/read/29680815/patient-trajectories-and-their-impact-on-mobility-social-participation-and-quality-of-life-in-patients-with-vertigo-dizziness-balance-disorders-and-osteoarthritis-mobile-tra-study-protocol-of-an-observational-practice-based-cohort-study
#9
Rebecca Kisch, Antje Bergmann, Daniela Koller, Reiner Leidl, Ulrich Mansmann, Martin Mueller, Linda Sanftenberg, Joerg Schelling, Leonie Sundmacher, Karen Voigt, Eva Grill
INTRODUCTION: Mobility limitations have a multitude of different negative consequences on elderly patients including decreasing opportunities for social participation, increasing the risk for morbidity and mortality. However, current healthcare has several shortcomings regarding mobility sustainment of older adults, namely a narrow focus on the underlying pathology, fragmentation of care across services and health professions and deficiencies in personalising care based on patients' needs and experiences...
April 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29679908/recent-advances-in-colony-stimulating-factor-1-receptor-c-fms-as-an-emerging-target-for-various-therapeutic-implications
#10
REVIEW
Archana Kumari, Om Silakari, Rajesh K Singh
Colony stimulating factor-1 (CSF-1) is one of the most common proinflammatory cytokine responsible for various inflammatory disorders. It has a remarkable role in the development and progression of osteoarthritis, cancer and other autoimmune disease conditions. The CSF-1 acts by binding to the receptor, called colony stimulating factor-1 receptor (CSF-1R) also known as c-FMS resulting in the cascade of signalling pathway causing cell proliferation and differentiation. Interleukin-34 (IL-34), recently identified as another ligand for CSF-IR, is a cytokine protein...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29678262/tolfenamic-acid
#11
Sofia Ahmed, Muhammad Ali Sheraz, Iqbal Ahmad
Tolfenamic acid (TA) is a nonsteroidal antiinflammatory drug and belongs to the group of fenamates. It is used as a potent pain reliever in the treatment of acute migraine attacks, and disorders like dysmenorrhea, rheumatoid, and osteoarthritis. TA has shown excellent in vitro antibacterial activity against certain ATCC strains of bacteria when complexed with bismuth(III). It has also been reported to block pathological processes associated with Alzheimer's disease. In the recent past, TA has also been used as a novel anticancer agent for the treatment of various cancers...
2018: Profiles of Drug Substances, Excipients, and related Methodology
https://www.readbyqxmd.com/read/29678192/engineering-in-vitro-stem-cell-based-vascularized-bone-models-for-drug-screening-and-predictive-toxicology
#12
REVIEW
Alessandro Pirosa, Riccardo Gottardi, Peter G Alexander, Rocky S Tuan
The production of veritable in-vitro models of bone tissue is essential to understand the biology of bone and its surrounding environment, to analyze the pathogenesis of bone diseases (e.g., osteoporosis, osteoarthritis, osteomyelitis, etc.), to develop effective therapeutic drug screening, and to test potential therapeutic strategies. Dysregulated interactions between vasculature and bone cells are often related to the aforementioned pathologies, underscoring the need for a bone model that contains engineered vasculature...
April 20, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29675632/factors-affecting-mortality-and-reoperations-in-high-energy-pelvic-fractures
#13
Peyman Bakhshayesh, Lars Weidenhielm, Anders Enocson
AIM: Factors affecting mortality during the first year following high-energy pelvic fractures has not been reported previously. Nor has surgical complications leading to reoperations been reported in a cohort with only high-energy pelvic trauma patients. OBJECTIVES: The aim of this study was to report and analyse factors affecting outcome, in terms of mortality and reoperations, up to 1 year after the injury in patients with a traumatic pelvic ring injury due to a high-energy trauma...
April 19, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29675022/immunoporosis-immunology-of-osteoporosis-role-of-t-cells
#14
REVIEW
Rupesh K Srivastava, Hamid Y Dar, Pradyumna K Mishra
The role of immune system in various bone pathologies, such as osteoporosis, osteoarthritis, and rheumatoid arthritis is now well established. This had led to the emergence of a modern field of systems biology called as osteoimmunology, an integrated research between fields of immunology and bone biology under one umbrella. Osteoporosis is one of the most common inflammatory bone loss condition with more than 200 million individuals affected worldwide. T helper (Th) cells along with various other immune cells are major players involved in bone homeostasis...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29674113/bio-based-strategies-for-producing-glycosaminoglycans-and-their-oligosaccharides
#15
REVIEW
Zhen Kang, Zhengxiong Zhou, Yang Wang, Hao Huang, Guocheng Du, Jian Chen
Glycosaminoglycans (GAGs) and their oligosaccharides have attracted extensive attention because of their wide applications in cosmetics, health, and clinical treatment of, for example, thrombus, osteoarthritis, rheumatism, and cancer. Compared to conventional preparation approaches, bio-based strategies for producing GAGs and their oligosaccharides are more promising because they avoid cross-infection of human and animal diseases, use green production processes, and can precisely control the degree of sulfation and molecular weight...
April 16, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/29671497/osteoarthritis-rapid-evidence-review
#16
Mark H Ebell
Osteoarthritis (OA) should be suspected in patients with pain in the fingers, shoulders, hips, knees, or ankles, especially if they are older than 40 years. Patients older than 50 years who have joint pain, minimal morning stiffness, and functional impairment likely have OA. Radiography can confirm the diagnosis and may be helpful before surgical referral, but findings generally do not correlate well with symptoms. Exercise, physical therapy, knee taping, and tai chi are beneficial for knee OA. Medical therapy provides modest benefits in pain reduction and functional improvement; however, nonsteroidal anti-inflammatory drugs, tramadol, and other opioids have significant potential harms...
April 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29665710/significance-of-incidental-intra-articular-and-peri-articular-fdg-avid-foci-on-pet-ct
#17
Wayne B Cohen-Levy, Juan Pretell-Mazzini, Adam D Singer, Ty Subhawong, Dylan N Greif, Jean Jose
Background Positron emission tomography/computed tomography (PET/CT) is a useful imaging adjunct in patients with sarcoma. Intra-articular and peri-articular 18F-fluoro-2-deoxy-D-glucose (FDG) avid lesions are often discovered incidentally. Purpose To describe the etiology, appearance, and standardized uptake values (SUV) of incidentally detected FDG avid intra-articular and peri-articular foci in patients with sarcoma. Material and Methods The institutional sarcoma database between November 2011 and November 2016 was retrospectively reviewed...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29665605/-shoulder-arthroplasty
#18
Anna Krukenberg, Jan-Philipp Imiolczyk, Philipp Moroder, Markus Scheibel
Shoulder arthroplasty has been performed increasingly during the last years. The concept of modern anatomic shoulder arthroplasty is based on C. S. Neer's first shoulder prosthesis in the 1950s which was originally designed for the treatment of fractures of the proximal humerus. Since then, this monoblock prosthesis has undergone many changes and improvements. By now, an anatomic reconstruction of the joint is possible. Hence, the indications for anatomic shoulder arthroplasty have been added amongst others by osteoarthritis, necrosis, rheumatoid arthritis or posttraumatic arthritis...
April 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29664187/exercise-interventions-and-patient-beliefs-for-people-with-hip-knee-or-hip-and-knee-osteoarthritis-a-mixed-methods-review
#19
REVIEW
Michael Hurley, Kelly Dickson, Rachel Hallett, Robert Grant, Hanan Hauari, Nicola Walsh, Claire Stansfield, Sandy Oliver
BACKGROUND: Chronic peripheral joint pain due to osteoarthritis (OA) is extremely prevalent and a major cause of physical dysfunction and psychosocial distress. Exercise is recommended to reduce joint pain and improve physical function, but the effect of exercise on psychosocial function (health beliefs, depression, anxiety and quality of life) in this population is unknown. OBJECTIVES: To improve our understanding of the complex inter-relationship between pain, psychosocial effects, physical function and exercise...
April 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29661229/can-arthroplasty-stem-influence-outcome-casino-a-randomized-controlled-equivalence-trial-of-125-mm-versus-150-mm-exeter-v40-stems-in-total-hip-arthroplasty
#20
David F Hamilton, Nicholas E Ohly, Paul Gaston
BACKGROUND: The use of shorter length femoral stems during total hip arthroplasty has been suggested to accommodate wider patient femoral geometry and offer maximal bone preservation. However, cemented short-stem designs may increase the risk of varus stem malalignment and influence patient outcomes. METHODS/DESIGN: CASINO is a multi-centre randomised equivalence trial that will recruit 220 patients undergoing total hip arthroplasty for osteoarthritis at two NHS hospitals in Scotland...
April 16, 2018: Trials
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