keyword
MENU ▼
Read by QxMD icon Read
search

Delayed cerebral ischemia

keyword
https://www.readbyqxmd.com/read/29023958/stroke-induced-chronic-systolic-dysfunction-driven-by-sympathetic-overactivity
#1
Michael Bieber, Rudolf A Werner, Edit Tanai, Ulrich Hofmann, Takahiro Higuchi, Kai Schuh, Peter U Heuschmann, Stefan Frantz, Oliver Ritter, Peter Kraft, Christoph Kleinschnitz
OBJECTIVE: Cardiac diseases are established risk factors for ischemic stroke incidence and severity. Conversely, there is increasing evidence that brain ischemia can cause cardiac dysfunction. The mechanisms underlying this neurogenic heart disease are incompletely understood. While it is established that ischemic stroke is associated with cardiac arrhythmias, myocardial damage, elevated cardiac enzymes and plasma catecholamines in the acute phase, nothing is known about the delayed consequences of ischemic stroke on cardiovascular function...
October 10, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29017857/administration-of-5-methoxyindole-2-carboxylic-acid-that-potentially-targets-mitochondrial-dihydrolipoamide-dehydrogenase-confers-cerebral-preconditioning-against-ischemic-stroke-injury
#2
Jinzi Wu, Rongrong Li, Wenjun Li, Ming Ren, Nopporn Thangthaeng, Nathalie Sumien, Ran Liu, Shaohua Yang, James W Simpkins, Michael J Forster, Liang-Jun Yan
The objective of this study was to investigate a possible role of mitochondrial dihydrolipoamide dehydrogenase (DLDH) as a chemical preconditioning target for neuroprotection against ischemic injury. We used 5-methoxyindole-2-carboxylic acid (MICA), a reportedly reversible DLDH inhibitor, as the preconditioning agent and administered MICA to rats mainly via dietary intake. Upon completion of 4 week's MICA treatment, rats underwent 1h transient ischemia and 24h reperfusion followed by tissue collection. Our results show that MICA protected the brain against ischemic stroke injury as the infarction volume of the brain from the MICA-treated group was significantly smaller than that from the control group...
October 7, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28991058/red-cell-distribution-width-after-subarachnoid-hemorrhage
#3
Vito Fontana, Ottavia Bond, Savino Spadaro, Filippo Annoni, Leda Nobile, Rafael Badenes, Carlo A Volta, Jean-L Vincent, Jacques Creteur, Fabio S Taccone
BACKGROUND: High red cell distribution width (RDW) values have been associated with increased hospital mortality in critically ill patients, but few data are available for subarachnoid hemorrhage (SAH). METHODS: We analyzed an institutional database of adult (>18 y) patients admitted to the Department of Intensive Care after nontraumatic SAH between January 2011 and May 2016. RDW (normal value, 10.9% to 13.4%) was obtained daily from admission for a maximum of 7 days, from routine blood analysis...
October 5, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28983856/effect-of-hhh-therapy-on-regional-cbf-after-severe-subarachnoid-hemorrhage-studied-by-bedside-xenon-enhanced-ct
#4
Henrik Engquist, Elham Rostami, Elisabeth Ronne-Engström, Pelle Nilsson, Anders Lewén, Per Enblad
BACKGROUND: Management of delayed cerebral ischemia (DCI) following subarachnoid hemorrhage (SAH) is difficult and still carries controversies. In this study, the effect of therapeutic hypervolemia, hemodilution, and hypertension (HHH-therapy) on cerebral blood flow (CBF) was assessed by xenon-enhanced computerized tomography (XeCT) hypothesizing an increase in CBF in poorly perfused regions. METHODS: Bedside XeCT measurements of regional CBF in mechanically ventilated SAH patients were routinely scheduled for day 0-3, 4-7, and 8-12...
October 5, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28981977/reduced-cbf-recovery-detected-by-longitudinal-3d-ssp-spect-analyses-predicts-outcome-of-postoperative-patients-after-subarachnoid-hemorrhage
#5
Tatsushi Mutoh, Tomoko Totsune, Shunsuke Takenaka, Yasuko Tatewaki, Manabu Nakagawa, Jose Ignacio Suarez, Yasuyuki Taki, Tatsuya Ishikawa
The aim of this study was to evaluate the impact of cerebral blood flow (CBF) recovery obtained from brain single-photon emission computed tomography (SPECT) images on postoperative outcome after aneurysmal subarachnoid hemorrhage (SAH). Twenty-nine patients who had undergone surgical clipping for ruptured anterior communicating artery aneurysms were analyzed prospectively. Routine measurements of CBF were performed using technetium-99m hexamethyl propyleneamine oxine SPECT on days 4 and 14 after SAH. Regional voxel data analyzed by three dimensional stereotactic surface projection (3D-SSP) were compared between patients and age-matched normal database (NDB)...
October 5, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28974630/predictors-of-outcome-in-aneurysmal-subarachnoid-hemorrhage-patients-observations-from-a-multicenter-data-set
#6
James P Galea, Louise Dulhanty, Hiren C Patel
BACKGROUND AND PURPOSE: The mortality and morbidity after aneurysmal subarachnoid hemorrhage has improved because of better diagnosis, early treatment to secure the aneurysm, and better management of disease-specific complications. With these improvements in care, it is not clear if the previously identified independent predictors of a negative outcome have changed. The aim of this study was to identify the independent predictors of an unfavorable outcome (Glasgow Outcome Score 1, 2, and 3) in aneurysmal subarachnoid hemorrhage patients...
October 3, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28973675/the-subarachnoid-hemorrhage-early-brain-edema-score-predicts-delayed-cerebral-ischemia-and-clinical-outcomes
#7
Sung-Ho Ahn, Jude P Savarraj, Mubashir Pervez, Wesley Jones, Jin Park, Sang-Beom Jeon, Sun U Kwon, Tiffany R Chang, Kiwon Lee, Dong H Kim, Arthur L Day, H Alex Choi
BACKGROUND: Early brain injury (EBI) after subarachnoid hemorrhage (SAH) is an important determinant of clinical outcomes. However, a major hindrance to studies of EBI is the lack of radiographic surrogate marker. OBJECTIVE: To propose a scoring system based on early changes in clinically obtained computed tomography (CT), called the Subarachnoid hemorrhage Early Brain Edema Score (SEBES). METHODS: Patients with spontaneous aneurysmal SAH and a CT within 24 h of ictus were included...
July 7, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28973669/transcranial-doppler-waveforms-during-intra-aortic-balloon-pump-counterpulsation-for-vasospasm-detection-after-subarachnoid-hemorrhage
#8
Nicholas A Morris, Nathan Manning, Randolph S Marshall, E Sander Connolly, Jan Claassen, Sachin Agarwal, David J Roh, J Michael Schmidt, Soojin Park
BACKGROUND: Transcranial Doppler ultrasound is a standard screening tool for vasospasm after subarachnoid hemorrhage. Prevention of vasospasm-induced delayed cerebral ischemia after subarachnoid hemorrhage depends on optimization of cerebral perfusion pressure, which can be challenged by neurogenic stress cardiomyopathy. Intra-aortic balloon pumps have been utilized to augment cerebral perfusion, but they change the transcranial Doppler waveform, altering its interpretability for vasospasm screening...
July 21, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28969107/intracarotid-sodium-nitroprusside-on-fifth-post-ischemic-stroke-day-in-middle-cerebral-artery-occlusion-rat-model
#9
Vinod Kumar Tewari, Vivek Bhosale, Rakesh Shukla, Hari Kishan Das Gupta, Sheeba
INTRODUCTION: Ischemic stroke at later stages (>4.5 hour) have very few treatment options left. In those cases Nitric Oxide (NO) may provide promising results. NO is active in signaling pathways. Sodium Nitroprusside (SNP), a NO donor was tested earlier in rat Middle Cerebral Artery Occlusion (MCAO) model in early stages (5-60 minutes) and found useful but in delayed stroke cases (60-120 minutes) found useless. This was due to local inducible Nitric Oxide Synthase Enzyme (iNOS) and superoxide (causes destructive effect) formation which was skipped...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28951554/endocytosis-and-lysosomal-degradation-of-glua2-3-ampars-in-response-to-oxygen-glucose-deprivation-in-hippocampal-but-not-cortical-neurons
#10
Zsombor Koszegi, Maria Fiuza, Jonathan G Hanley
Global cerebral ischemia results in oxygen and glucose deprivation (OGD) and consequent delayed cell death of vulnerable neurons, with hippocampal CA1 neurons more vulnerable than cortical neurons. Most AMPA receptors (AMPARs) are heteromeric complexes of subunits GluA1/GluA2 or GluA2/GluA3, and the presence of GluA2 renders AMPARs Ca(2+)-impermeable. In hippocampal CA1 neurons, OGD causes the synaptic expression of GluA2-lacking Ca(2+)-permeable AMPARs, contributing to toxic Ca(2+) influx. The loss of synaptic GluA2 is caused by rapid trafficking of GluA2-containing AMPARs from the cell surface, followed by a delayed reduction in GluA2 mRNA expression...
September 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28951276/early-transient-mild-hypothermia-attenuates-neurological-deficits-and-brain-damage-after-experimental-subarachnoid-hemorrhage-in-rats
#11
Nadine Lilla, Christoph Rinne, Judith Weiland, Thomas Linsenmann, Ralf-Ingo Ernestus, Thomas Westermaier
OBJECTIVE: Metabolic exhaustion in ischemic tissue is the basis for a detrimental cascade of cell damage. In the acute stage of subarachnoid hemorrhage (SAH), a sequence of global and focal ischemia occurs, threatening brain tissue to undergo ischemic damage. This study was conducted to investigate whether early therapy with moderate hypothermia can offer neuroprotection after experimental SAH. MATERIALS AND METHODS: 20 male Sprague-Dawley rats were subjected to SAH and treated by active cooling (34° C) or served as controls by continuous maintenance of normothermia (37...
September 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28950909/systemic-impact-on-secondary-brain-aggravation-due-to-ischemia-reperfusion-injury-in-post-cardiac-arrest-syndrome-a-prospective-observational-study-using-high-mobility-group-box-1-protein
#12
Atsunori Sugita, Kosaku Kinoshita, Atsushi Sakurai, Nobutaka Chiba, Junko Yamaguchi, Tsukasa Kuwana, Nami Sawada, Satoshi Hori
BACKGROUND: Ischemia/reperfusion injury (I/R) is an important pathophysiology of post-cardiac arrest syndrome (PCAS) against multiple organ dysfunction and mortality. The inflammatory response in PCAS causes systemic I/R. The purpose of this study was to demonstrate the pathophysiology of systemic I/R for secondary brain damage using the biomarkers high-mobility group box 1 (HMGB1), neuron-specific enolase (NSE), and interleukin-6 (IL-6). METHODS: This study was designed as a single-institution prospective observational study...
September 26, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28948569/blood-free-radicals-concentration-determined-by-electron-paramagnetic-resonance-spectroscopy-and-delayed-cerebral-ischemia-occurrence-in-patients-with-aneurysmal-subarachnoid-hemorrhage
#13
Grzywna Ewelina, Stachura Krzysztof, Moskala Marek, Kruczala Krzysztof
Pathophysiology of delayed cerebral ischemia and cerebral vasospasm following aneurysmal subarachnoid hemorrhage is still poorly recognized, however free radicals are postulated as one of the crucial players. This study was designed to scrutinize whether the concentration of free radicals in the peripheral venous blood is related to the occurrence of delayed cerebral ischemia associated with cerebral vasospasm. Twenty-four aneurysmal subarachnoid hemorrhage patients and seven patients with unruptured intracranial aneurysm (control group) have been studied...
September 25, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28946178/the-impact-of-temporary-clipping-during-aneurysm-surgery-on-the-incidence-of-delayed-cerebral-ischemia-after-aneurysmal-subarachnoid-hemorrhage
#14
Vesna Malinova, Bawarjan Schatlo, Martin Voit, Patricia Suntheim, Veit Rohde, Dorothee Mielke
OBJECTIVE Clipping of a ruptured intracranial aneurysm requires some degree of vessel manipulation, which in turn is believed to contribute to vasoconstriction. One of the techniques used during surgery is temporary clipping of the parent vessel. Temporary clipping may either be mandatory in cases of premature rupture (rescue) or represent a precautionary or facilitating surgical step (elective). The aim of this study was to study the association between temporary clipping during aneurysm surgery and the incidence of vasospasm and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage (aSAH) in a large clinical series...
September 15, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28945859/high-dose-nadroparin-following-endovascular-aneurysm-treatment-benefits-outcome-after-aneurysmal-subarachnoid-hemorrhage
#15
Rene Post, IJsbrand A J Zijlstra, Rene van den Berg, Bert A Coert, Dagmar Verbaan, W Peter Vandertop
BACKGROUND: Delayed cerebral ischemia (DCI) is one of the major causes of delayed morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (aSAH). OBJECTIVE: To evaluate the effect of high-dose nadroparin treatment following endovascular aneurysm treatment on the occurrence of DCI and clinical outcome. METHODS: Medical records of 158 adult patients with an aSAH were retrospectively analyzed. Those patients treated endovascularly for their ruptured aneurysm were included in this study...
July 27, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28934895/high-early-fluid-input-after-aneurysmal-subarachnoid-hemorrhage-combined-report-of-association-with-delayed-cerebral-ischemia-and-feasibility-of-cardiac-output-guided-fluid-restriction
#16
Leonie J M Vergouw, Mohamud Egal, Bas Bergmans, Diederik W J Dippel, Hester F Lingsma, Mervyn D I Vergouwen, Peter W A Willems, Annemarie W Oldenbeuving, Jan Bakker, Mathieu van der Jagt
BACKGROUND: Guidelines on the management of aneurysmal subarachnoid hemorrhage (aSAH) recommend euvolemia, whereas hypervolemia may cause harm. We investigated whether high early fluid input is associated with delayed cerebral ischemia (DCI), and if fluid input can be safely decreased using transpulmonary thermodilution (TPT). METHODS: We retrospectively included aSAH patients treated at an academic intensive care unit (2007-2011; cohort 1) or managed with TPT (2011-2013; cohort 2)...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28929378/external-ventricular-drains-after-subarachnoid-hemorrhage-is-less-more
#17
David Y Chung, Stephan A Mayer, Guy A Rordorf
External ventricular drains (EVD) are essential in the early management of hydrocephalus and elevated intracranial pressure after subarachnoid hemorrhage (SAH). Once in place, management of the EVD is thought to influence long-term patient outcomes, rates of ventriculitis, incidence of delayed cerebral ischemia, need for a ventriculoperitoneal shunt, and intensive care unit (ICU) and hospital length of stay. The available evidence supports adopting early clamp trials and intermittent cerebrospinal fluid (CSF) drainage...
September 19, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28887094/salvianolic-acids-for-injection-safi-promotes-functional-recovery-and-neurogenesis-via-sonic-hedgehog-pathway-after-stroke-in-mice
#18
Ye Zhang, Xiangjian Zhang, Lili Cui, Rong Chen, Cong Zhang, Yaoru Li, Tingting He, Xingyuan Zhu, Zuyuan Shen, Lipeng Dong, Jingru Zhao, Ya Wen, Xiufen Zheng, Pan Li
There is a pressing need of developing approaches for delayed post-stroke therapy for patients who fail to receive thrombolysis within the narrow time window. Neuroprotection of Salvianolic Acids for Injection (SAFI) for cerebral ischemia-reperfusion injury in acute phase has been well documented. The current study was to determine the influence of SAFI at the subacute phase after stroke in mice, and to elucidate the underlying mechanisms. Adult male C57BL/6 mice were subjected to permanent occlusion of the distal middle cerebral artery (dMCAO), followed by daily intraperitoneal injection of SAFI 24 h after stroke for 14 days...
September 5, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28879893/a-novel-swine-model-of-subarachnoid-hemorrhage-induced-cerebral-vasospasm
#19
Zion Zibly, Lory Fein, Mayur Sharma, Yaron Assaf, Anton Wohl, Sagi Harnof
OBJECTIVE: One of the most serious complications following subarachnoid hemorrhage (SAH) is delayed cerebral ischemia (DCI) secondary to symptomatic vasospasm. An animal model mimicking post SAH vasospasm is essential for enabling the translation of newer technologies from the conceptual phase to animal studies, and eventually to clinical trials. Various animal models of DCI following SAH have been reported, with canine models being the most common. Due to the similarity of the swine cardiovascular system and its dimensions to the human's system, the main objective of this study was to establish a consistent and quantitatively representative model of SAH-induced vasospasm in swine...
September 2017: Neurology India
https://www.readbyqxmd.com/read/28867315/soluble-fms-like-tyrosine-kinase-1-sflt-1-and-risk-of-cerebral-vasospasm-after-aneurysmal-subarachnoid-hemorrhage
#20
Christoph J Griessenauer, Michelle H Chua, Khalid A Hanafy, Yaw Tachie Baffour, Ruiya Chen, Robert H LeBlanc, Apar S Patel, Mohamed Salem, S Ananth Karumanchi, Dihua Xu, Ravi Thadhani, Christopher S Ogilvy, Ajith J Thomas
INTRODUCTION: The molecular mechanisms underlying cerebral vasospasm and delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) are incompletely understood. We hypothesized that circulating anti-angiogenic factors, such as soluble Fms-like tyrosine kinase-1 (sFlt-1) and soluble transforming growth factor β (TGFβ) co-receptor, soluble endoglin (sEng), are important markers of their pathophysiology. METHODS: We performed a prospective study in aSAH patients and measured cerebrospinal fluid (CSF) and serum levels of sFlt-1 and sEng on post-bleed day 1 and 6 and correlated levels with incidence and severity of cerebral vasospasm and DCI...
August 31, 2017: World Neurosurgery
keyword
keyword
116797
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"