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Delayed cerebral ischemia

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https://www.readbyqxmd.com/read/29445328/hippocampal-atrophy-following-subarachnoid-hemorrhage-correlates-with-disruption-of-astrocyte-morphology-and-capillary-coverage-by-aqp4
#1
Maryam Anzabi, Maryam Ardalan, Nina K Iversen, Ali H Rafati, Brian Hansen, Leif Østergaard
Despite successful management of ruptured intracranial aneurysm following subarachnoid hemorrhage (SAH), delayed cerebral ischemia (DCI) remains the main cause of high mortality and morbidity in patients who survive the initial bleeding. Astrocytes play a key role in neurovascular coupling. Therefore, changes in the neurovascular unit including astrocytes following SAH may contribute to the development of DCI and long-term complications. In this study, we characterized morphological changes in hippocampal astrocytes following experimental SAH, with special emphasis on glia-vascular cross-talk and hippocampal volume changes...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29439196/reduced-intravoxel-incoherent-motion-microvascular-perfusion-predicts-delayed-cerebral-ischemia-and-vasospasm-after-aneurysm-rupture
#2
Jeremy J Heit, Max Wintermark, Blake W Martin, Guangming Zhu, Michael P Marks, Greg Zaharchuk, Robert L Dodd, Huy M Do, Gary K Steinberg, Maarten G Lansberg, Gregory W Albers, Christian Federau
BACKGROUND AND PURPOSE: Proximal artery vasospasm and delayed cerebral ischemia (DCI) after cerebral aneurysm rupture result in reduced cerebral perfusion and microperfusion and significant morbidity and mortality. Intravoxel incoherent motion (IVIM) magnetic resonance imaging extracts microvascular perfusion information from a multi-b value diffusion-weighted sequence. We determined whether decreased IVIM perfusion may identify patients with proximal artery vasospasm and DCI. METHODS: We performed a pilot retrospective cohort study of patients with ruptured cerebral aneurysms...
February 9, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29422368/long-term-outcomes-of-low-profile-visualized-intraluminal-support-device-usage-in-stent-assisted-coiling-of-intracranial-aneurysm
#3
Dong Hyun Yoo, Young Dae Cho, Jusun Moon, Jeongjun Lee, Hyun-Seung Kang, Won-Sang Cho, Jeong Eun Kim, Gyojun Hwang, O-Ki Kwon, Moon Hee Han
Stent-assisted coil embolization technique have broadened indications for endovascular therapy of aneurysms. The Low-profile Visualized Intraluminal Support device (LVIS) is a self-expanding, nitinol single-braid and closed-cell device introduced fairly recently. We aim to evaluate long-term outcome of LVIS device in stent-assisted coiling of intracranial aneurysms. Between October 2012 and February 2013, a total of 55 patients with unruptured wide-necked intracranial aneurysms underwent coil embolization procedures involving LVIS devices...
February 5, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29420085/reactive-oxygen-species-play-a-biphasic-role-in-brain-ischemia
#4
Jiping Yang, Jinchong Qi, Baoxin Xiu, Bei Yang, Caihong Niu, Hua Yang
OBJECTIVE: Reactive oxygen species (ROS) are the essential mechanism involving in the ischemic process. Due to their complex characteristics, the precise effects of ROS on post-ischemic neurons remain uncertain. This study aimed to investigate the potential role of ROS in brain ischemia. METHODS: Dynamic ROS levels in the perifocal cortex were evaluated after right middle cerebral artery occlusion (MCAO) of SD rats. Furthermore the role of ROS was assessed following delayed treatment with the ROS scavenger dimethylthiourea (DMTU) after brain ischemia...
February 8, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29414883/possible-role-of-inflammation-and-galectin-3-in-brain-injury-after-subarachnoid-hemorrhage
#5
REVIEW
Hirofumi Nishikawa, Hidenori Suzuki
Aneurysmal subarachnoid hemorrhage (SAH) is known as one of the most devastating diseases in the central nervous system. In the past few decades, research on SAH has focused on cerebral vasospasm to prevent post-SAH delayed cerebral ischemia (DCI) and to improve outcomes. However, increasing evidence has suggested that early brain injury (EBI) is an important mechanism contributing to DCI, cerebral vasospasm as well as poor outcomes. Though the mechanism of EBI is very complex, inflammation is thought to play a pivotal role in EBI...
February 7, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29395650/remote-limb-ischemic-conditioning-during-cerebral-ischemia-reduces-infarct-size-through-enhanced-collateral-circulation-in-murine-focal-cerebral-ischemia
#6
Kazuo Kitagawa, Moeko Saitoh, Kentaro Ishizuka, Satoru Shimizu
BACKGROUND: Remote ischemic conditioning (RIC) induces protection in focal cerebral ischemia. The conditioning is divided into pre-, per-, and postconditioning. However, the mechanisms of RIC remain unknown. OBJECTIVES: This study aimed to determine the most effective subtype of RIC. We also examined involvement of collateral circulation on RIC. METHODS: Transient middle cerebral artery occlusion (MCAO) was performed with nylon sutures in adult C57BL/6 mice under the monitoring of cerebral blood flow (CBF)...
January 29, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29395648/delayed-administration-of-the-glucagon-like-peptide-1-analog-liraglutide-promoting-angiogenesis-after-focal-cerebral-ischemia-in-mice
#7
Yanxia Chen, Xiangjian Zhang, Junna He, Yanzhao Xie, Yang Yang
BACKGROUND: Glucagon-like peptide 1 (GLP-1) analogs administered before or after cerebral ischemia have been shown to provide neuroprotection. Here, we explored whether delayed administration of a GLP-1 analog, liraglutide, could improve long-term functional recovery and promote angiogenesis after stroke. MATERIALS AND METHODS: In the present study, mice were established as a focal cerebral cortical ischemia model and were intraperitoneally administered liraglutide or normal saline (NS) daily for 14 consecutive days, starting 1 day after cerebral ischemia...
January 21, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29394184/cerebral-autoregulation-in-the-prediction-of-delayed-cerebral-ischemia-and-clinical-outcome-in-poor-grade-aneurysmal-subarachnoid-hemorrhage-patients
#8
Max Gaasch, Alois J Schiefecker, Mario Kofler, Ronny Beer, Verena Rass, Bettina Pfausler, Claudius Thomé, Erich Schmutzhard, Raimund Helbok
OBJECTIVES: Pressure reactivity index and oxygen reactivity index are used to assess cerebral autoregulation after acute brain injury. The value of autoregulation indices in the prediction of delayed cerebral ischemia and outcome in patients with subarachnoid hemorrhage is still inconclusive. In this study, we aimed to focus on the predictive value of the first 72 hours commonly referred to as "early brain injury" in comparison to the overall monitoring period. DESIGN: Retrospective observational cohort study...
February 1, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29393750/desmopressin-administration-and-rebleeding-in-subarachnoid-hemorrhage-analysis-of-an-observational-prospective-database
#9
Charles L Francoeur, David Roh, J Michael Schmidt, Stephan A Mayer, M Cristina Falo, Sachin Agarwal, E Sander Connolly, Jan Claassen, Mitchell S V Elkind, Soojin Park
OBJECTIVE Rebleeding remains a frequent and catastrophic event leading to poor outcome after subarachnoid hemorrhage (SAH). Reduced platelet function after the initial bleed is associated with higher risk of early rebleeding. Desmopressin (DDAVP) is a well-known hemostatic agent, and recent guidelines already suggest its use in individuals exposed to antiplatelet drugs. The authors hypothesized that DDAVP administration in patients with SAH at admission would be associated with lower risks of rebleeding. METHODS The authors performed an observational cohort study of patients enrolled in the Columbia University SAH Outcome Project between August 1996 and July 2015...
February 2, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29382802/acute-or-delayed-systemic-administration-of-human-amnion-epithelial-cells-improves-outcomes-in-experimental-stroke
#10
Megan A Evans, Rebecca Lim, Hyun Ah Kim, Hannah X Chu, Chantelle V Gardiner-Mann, Kimberly W E Taylor, Christopher T Chan, Vanessa H Brait, Seyoung Lee, Quynh Nhu Dinh, Antony Vinh, Thanh G Phan, Velandai K Srikanth, Henry Ma, Thiruma V Arumugam, David Y Fann, Luting Poh, Cameron P J Hunt, Colin W Pouton, John M Haynes, Stavros Selemidis, William Kwan, Leon Teo, James A Bourne, Silke Neumann, Sarah Young, Emma K Gowing, Grant R Drummond, Andrew N Clarkson, Euan M Wallace, Christopher G Sobey, Brad R S Broughton
BACKGROUND AND PURPOSE: Human amnion epithelial cells (hAECs) are nonimmunogenic, nontumorigenic, anti-inflammatory cells normally discarded with placental tissue. We reasoned that their profile of biological features, wide availability, and the lack of ethical barriers to their use could make these cells useful as a therapy in ischemic stroke. METHODS: We tested the efficacy of acute (1.5 hours) or delayed (1-3 days) poststroke intravenous injection of hAECs in 4 established animal models of cerebral ischemia...
January 30, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29361548/maturation-of-neural-stem-cells-and-integration-into-hippocampal-circuits-functional-study-in-post-ischemia-in-situ
#11
Olga Kopach, Oksana Rybachuk, Volodymyr Krotov, Vitalii Kyryk, Nana Voitenko, Tatyana Pivneva
The hippocampus is the most susceptible region of the brain to ischemic lesion, with highly vulnerable pyramidal interneurons to ischemic cell death. A restricted brain neurogenesis limits a withdrawal of massive cell death after stroke that endorses cell-based therapies for neuronal replacement strategies following cerebral ischemia. Neurons differentiated from neural stem/progenitor cells (NSPCs) matured and integrated into host circuitry, improving recovery after stroke. However, how host environment regulates the NSPC behaviour in post-ischemic tissue remains unknown...
January 5, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29351673/the-barrow-neurological-institute-grading-scale-as-a-predictor-for-delayed-cerebral-ischemia-and-outcome-after-aneurysmal-subarachnoid-hemorrhage-data-from-a-nationwide-patient-registry-swiss-sos
#12
Marian Christoph Neidert, Nicolai Maldaner, Martin Nikolaus Stienen, Michel Roethlisberger, Daniel W Zumofen, Donato D'Alonzo, Serge Marbacher, Rodolfo Maduri, Isabel Charlotte Hostettler, Bawarjan Schatlo, Michel M Schneider, Martin A Seule, Daniel Schöni, Johannes Goldberg, Christian Fung, Marta Arrighi, Daniele Valsecchi, Philippe Bijlenga, Karl Schaller, Oliver Bozinov, Luca Regli, Jan-Karl Burkhardt
BACKGROUND: The Barrow Neurological Institute (BNI) scale is a novel quantitative scale measuring maximal subarachnoid hemorrhage (SAH) thickness to predict delayed cerebral ischemia (DCI). This scale could replace the Fisher score, which was traditionally used for DCI prediction. OBJECTIVE: To validate the BNI scale. METHODS: All patient data were obtained from the prospective aneurysmal SAH multicenter registry. In 1321 patients, demographic data, BNI scale, DCI, and modified Rankin Scale (mRS) score up to the 1-yr follow-up (1FU) were available for descriptive and univariate statistics...
January 17, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29335333/predictors-of-in-hospital-death-after-aneurysmal-subarachnoid-hemorrhage-analysis-of-a-nationwide-database-swiss-sos-swiss-study-on-aneurysmal-subarachnoid-hemorrhage
#13
Martin Nikolaus Stienens, Menno Germans, Jan-Karl Burkhardt, Marian C Neidert, Christian Fung, David Bervini, Daniel Zumofen, Michel Röthlisberger, Serge Marbacher, Rodolfo Maduri, Thomas Robert, Martin A Seule, Philippe Bijlenga, Karl Schaller, Javier Fandino, Nicolas R Smoll, Nicolai Maldaner, Sina Finkenstädt, Giuseppe Esposito, Bawarjan Schatlo, Emanuela Keller, Oliver Bozinov, Luca Regli
BACKGROUND AND PURPOSE: To identify predictors of in-hospital mortality in patients with aneurysmal subarachnoid hemorrhage and to estimate their impact. METHODS: Retrospective analysis of prospective data from a nationwide multicenter registry on all aneurysmal subarachnoid hemorrhage cases admitted to a tertiary neurosurgical department in Switzerland (Swiss SOS [Swiss Study on Aneurysmal Subarachnoid Hemorrhage]; 2009-2015). Both clinical and radiological independent predictors of in-hospital mortality were identified, and their effect size was determined by calculating adjusted odds ratios (aORs) using multivariate logistic regression...
January 15, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29330155/amlexanox-inhibits-cerebral-ischemia-induced-delayed-astrocytic-high-mobility-group-box-1-release-and-subsequent-brain-damage
#14
Sebok Kumar Halder, Hiroshi Ueda
High-mobility group box 1 (HMGB1) is increased in the cerebrospinal fluid (CSF) and serum during the early- and late-phases of brain ischemia and is known to contribute to brain damage. However, detailed characterization underlying cell type-specific HMGB1 release and pathophysiological roles of extracellularly released HMGB1 in ischemic brain remain unclear. Here, we examined cell type-specific HMGB1 release and therapeutic potential of amlexanox, an inhibitor of non-classical release, and an anti-HMGB1 antibody against ischemic brain damage...
January 12, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29325957/effect-and-feasibility-of-therapeutic-hypothermia-in-patients-with-hemorrhagic-stroke-a-systematic-review-and-meta-analysis
#15
REVIEW
Zhong Yao, Chao You, Min He
INTRODUCTION: Therapeutic hypothermia (TH) has shown a good performance in the experimental hemorrhagic stroke. But the clinical application of TH remains controversial since reports regarding its therapeutic effect are inconsistent. METHODS: We conducted a systematic review based on Preferred Reporting Items for Systematic Reviews and Meta-analyses. Compare TH with control group in terms of mortality, the poor outcome, delayed cerebral ischemia (DCI) and specific complications...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29315561/faim2-contributes-to-neuroprotection-by-erythropoietin-in-transient-brain-ischemia
#16
Daniel Komnig, Karen Gertz, Pardes Habib, Kay W Nolte, Tareq Meyer, Marc A Brockmann, Matthias Endres, Birgit Rathkolb, Martin Hrabě de Angelis, Jörg B Schulz, Björn H Falkenburger, Arno Reich
Delayed cell death in the penumbra region of acute ischemic stroke occurs through apoptotic mechanisms, making it amenable to therapeutic interventions. Fas/CD95 mediates apoptotic cell death in response to external stimuli. In mature neurons, Fas/CD95 signaling is modulated by Fas-apoptotic inhibitory molecule 2 (Faim2), which reduces cell death in animal models of stroke, meningitis, and Parkinson disease. Erythropoietin (EPO) has been studied as a therapeutic strategy in ischemic stroke. Erythropoietin stimulates the phosphatidylinositol-3 kinase/Akt (PI3K/Akt) pathway, which regulates Faim2 expression...
January 8, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29296615/minocycline-protects-against-delayed-cerebral-ischemia-after-subarachnoid-hemorrhage-via-matrix-metalloproteinase-9-inhibition
#17
Ananth K Vellimana, Meng-Liang Zhou, Itender Singh, Diane J Aum, James W Nelson, Glenn R Harris, Umeshkumar Athiraman, Byung H Han, Gregory J Zipfel
Objective: Delayed cerebral ischemia (DCI) is an independent risk factor for poor outcome after aneurysmal subarachnoid hemorrhage (SAH) and is multifactorial in etiology. While prior studies have suggested a role for matrix metalloproteinase-9 (MMP-9) in early brain injury after SAH, its contribution to the pathophysiology of DCI is unclear. Methods: In the first experiment, wild-type (WT) and MMP-9 -/- mice were subjected to sham or endovascular perforation SAH surgery...
December 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29288070/neonatal-erythropoietin-mitigates-impaired-gait-social-interaction-and-diffusion-tensor-imaging-abnormalities-in-a-rat-model-of-prenatal-brain-injury
#18
Shenandoah Robinson, Christopher J Corbett, Jesse L Winer, Lindsay A S Chan, Jessie R Maxwell, Christopher V Anstine, Tracylyn R Yellowhair, Nicholas A Andrews, Yirong Yang, Laurel O Sillerud, Lauren L Jantzie
Children who are born preterm are at risk for encephalopathy of prematurity, a leading cause of cerebral palsy, cognitive delay and behavioral disorders. Current interventions are limited and none have been shown to reverse cognitive and behavioral impairments, a primary determinant of poor quality of life for these children. Moreover, the mechanisms of perinatal brain injury that result in functional deficits and imaging abnormalities in the mature brain are poorly defined, limiting the potential to target interventions to those who may benefit most...
December 26, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29283314/delayed-inhibition-of-tonic-inhibition-enhances-functional-recovery-following-experimental-ischemic-stroke
#19
James E Orfila, Himmat Grewal, Robert M Dietz, Frank Strnad, Takeru Shimizu, Myriam Moreno, Christian Schroeder, Joan Yonchek, Krista M Rodgers, Andra Dingman, Timothy J Bernard, Nidia Quillinan, Wendy B Macklin, Richard J Traystman, Paco S Herson
The current study focuses on the ability to improve cognitive function after stroke with interventions administered at delayed/chronic time points. In light of recent studies demonstrating delayed GABA antagonists improve motor function, we utilized electrophysiology, biochemistry and neurobehavioral methods to investigate the role of α5 GABAA receptors on hippocampal plasticity and functional recovery following ischemic stroke. Male C57Bl/6 mice were exposed to 45 min transient middle cerebral artery occlusion and analysis of synaptic and functional deficits performed 7 or 30 days after recovery...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29275501/baicalin-attenuates-blood-brain-barrier-disruption-and-hemorrhagic-transformation-and-improves-neurological-outcome-in-ischemic-stroke-rats-with-delayed-t-pa-treatment-involvement-of-onoo-mmp-9-pathway
#20
Hansen Chen, Binghe Guan, Xi Chen, Xingmiao Chen, Caiming Li, Jinhua Qiu, Dan Yang, Ke Jian Liu, Suhua Qi, Jiangang Shen
Tissue plasminogen activator (t-PA) has a restrictive therapeutic window within 4.5 h after ischemic stroke with the risk of hemorrhagic transformation (HT) and neurotoxicity when it is used beyond the time window. In the present study, we tested the hypothesis that baicalin, an active compound of medicinal plant, could attenuate HT in cerebral ischemia stroke with delayed t-PA treatment. Male Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) for 4.5 h and then continuously received t-PA infusion (10 mg/kg) for 0...
December 23, 2017: Translational Stroke Research
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