keyword
MENU ▼
Read by QxMD icon Read
search

Delayed cerebral ischemia

keyword
https://www.readbyqxmd.com/read/29689403/delayed-cerebral-ischemia-and-vasospasm-after-spontaneous-angiogram-negative-subarachnoid-hemorrhage-an-updated-meta-analysis
#1
Si Un Lee, Eun Pyo Hong, Bong Jun Kim, Sung-Eun Kim, Jin Pyeong Jeon
OBJECT: To provide an update on the clinical outcomes such as delayed cerebral ischemia (DCI) and vasospasm in angiogram-negative subarachnoid hemorrhage (SAH), according to hemorrhage patterns, perimesencephalic SAH (PMH) and non-PMH. METHODS: Online databases from January 1990 to December 2017 were systematically reviewed. A fixed-effect model was used to control heterogeneity. To resolve publication bias, the trim and fill method was used to estimate the number of missing studies and adjusted odds ratio (OR)...
April 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29659999/increased-body-mass-index-associated-with-reduced-risk-of-delayed-cerebral-ischemia-and-subsequent-infarction-after-aneurysmal-subarachnoid-hemorrhage
#2
Lorenzo Rinaldo, Alejandro A Rabinstein, Giuseppe Lanzino
BACKGROUND: Increased body mass index (BMI) may be protective against cerebral ischemia in certain clinical contexts. OBJECTIVE: To investigate whether increased BMI was associated with delayed cerebral ischemia (DCI) and subsequent infarction after aneurysmal subarachnoid hemorrhage (aSAH). METHODS: We retrospectively reviewed the clinical course of patients presenting to our institution for management of aSAH. Patient were segregated according to BMI< or ≥29...
April 4, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29659050/continuous-electroencephalography-predicts-delayed-cerebral-ischemia-after-subarachnoid-hemorrhage-a-prospective-study-of-diagnostic-accuracy
#3
Eric S Rosenthal, Siddharth Biswal, Sahar F Zafar, Kathryn L O'Connor, Sophia Bechek, Apeksha V Shenoy, Emily J Boyle, Mouhsin M Shafi, Emily J Gilmore, Brandon P Foreman, Nicolas Gaspard, Thabele M Leslie-Mazwi, Jonathan Rosand, Daniel B Hoch, Cenk Ayata, Sydney S Cash, Andrew J Cole, Aman B Patel, M Brandon Westover
OBJECTIVE: Delayed cerebral ischemia (DCI) is a common, disabling complication of subarachnoid hemorrhage (SAH). Preventing DCI is a key focus of neurocritical care, but interventions carry risk and cannot be applied indiscriminately. While retrospective studies have identified continuous EEG (cEEG) measures associated with DCI, no study has characterized the accuracy of cEEG with sufficient rigor to justify using it to triage patients to interventions or clinical trials. We therefore prospectively assessed the accuracy of cEEG for predicting DCI, following the Standards for Reporting Diagnostic Accuracy Studies...
April 16, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29651748/improved-reperfusion-and-vasculoprotection-by-the-poly-adp-ribose-polymerase-inhibitor-pj34-after-stroke-and-thrombolysis-in-mice
#4
Mohamad El Amki, Dominique Lerouet, Marie Garraud, Fei Teng, Virginie Beray-Berthat, Bérard Coqueran, Benoît Barsacq, Charlotte Abbou, Bruno Palmier, Catherine Marchand-Leroux, Isabelle Margaill
Benefits from thrombolysis with recombinant tissue plasminogen activator (rt-PA) after ischemic stroke remain limited due to a narrow therapeutic window, low reperfusion rates, and increased risk of hemorrhagic transformations (HT). Experimental data showed that rt-PA enhances the post-ischemic activation of poly(ADP-ribose)polymerase (PARP) which in turn contributes to blood-brain barrier injury. The aim of the present study was to evaluate whether PJ34, a potent PARP inhibitor, improves poor reperfusion induced by delayed rt-PA administration, exerts vasculoprotective effects, and finally increases the therapeutic window of rt-PA...
April 12, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29650786/association-of-quantified-location-specific-blood-volumes-with-delayed-cerebral-ischemia-after-aneurysmal-subarachnoid-hemorrhage
#5
W E van der Steen, I A Zijlstra, D Verbaan, A M M Boers, C S Gathier, R van den Berg, G J E Rinkel, B A Coert, Y B W E M Roos, C B L M Majoie, H A Marquering
BACKGROUND AND PURPOSE: Delayed cerebral ischemia is a severe complication of aneurysmal SAH and is associated with a high case morbidity and fatality. The total blood volume and the presence of intraventricular blood on CT after aneurysmal SAH are associated with delayed cerebral ischemia. Whether quantified location-specific (cisternal, intraventricular, parenchymal, and subdural) blood volumes are associated with delayed cerebral ischemia has been infrequently researched. This study aimed to associate quantified location-specific blood volumes with delayed cerebral ischemia...
April 12, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29644488/brain-ischemic-preconditioning-protects-against-moderate-not-severe-transient-global-cerebral-ischemic-injury
#6
Jae-Chul Lee, Bich-Na Shin, Jeong Hwi Cho, Tae-Kyeong Lee, In Hye Kim, YooHun Noh, Sung-Su Kim, Hyang-Ah Lee, Young-Myeong Kim, Hyeyoung Kim, Jun Hwi Cho, Joon Ha Park, Ji Hyeon Ahn, Il Jun Kang, In Koo Hwang, Moo-Ho Won, Myoung Cheol Shin
Ischemic preconditioning (IPC) in the brain increases ischemic tolerance to subsequent ischemic insults. In this study, we examined whether IPC protects neurons and attenuates microgliosis or not in the hippocampus following severe transient global cerebral ischemia (TCI) in gerbils. Gerbils were assigned to 8 groups; 5- and 15-min sham operated groups, 5-min and 15-min TCI operated groups, IPC plus 5- and 15-min sham operated groups, and IPC plus 5- and 15-min TCI operated groups. IPC was induced by subjecting animals to 2-min transient ischemia 1 day before 5-min TCI for a typical transient ischemia and 15-min TCI for severe transient ischemia...
April 12, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29626425/salidroside-improves-brain-ischemic-injury-by-activating-pi3k-akt-pathway-and-reduces-complications-induced-by-delayed-tpa-treatment
#7
Wei Zuo, Feng Yan, Bo Zhang, Xiaomin Hu, Dan Mei
Cerebral ischemia causes blood-brain barrier (BBB) injury and thus increases the risk of complications secondary to thrombolysis, which limited its clinical application. This study aims to clarify the role and mechanism of salidroside (SALD) in alleviating brain ischemic injury and whether pretreatment of it could improve prognosis of delayed treatment of tissue plasminogen activator (t-PA). Rats were subjected to 3h of middle cerebral artery occlusion (MCAO) and were intraperitoneally administered with 10, 20 or 40mg/kg SALD before ischemia...
April 4, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29625115/administration-of-placenta-derived-mesenchymal-stem-cells-counteracts-a-delayed-anergic-state-following-a-transient-induction-of-endogenous-neurogenesis-activity-after-global-cerebral-ischemia
#8
A Ra Kho, Ok Joon Kim, Jeong Hyun Jeong, Ji Min Yu, Hye Sun Kim, Bo Young Choi, Sang Won Suh, Tae Nyoung Chung
BACKGROUND: Global cerebral ischemia (GCI) is a major obstacle for cardiac arrest survival. Recent studies have suggested the possibility of mesenchymal stem cell (MSC) as a novel therapeutic option for GCI, but these results were limited to the neuroprotective effects of MSCs. Therefore, we aimed to investigate specific characteristics of neurogenesis after transient GCI, and to assess the effect of MSC on these characteristics. METHODS: Adult male Sprague-Dawley rats were subjected to 7 minutes of transient GCI and randomized into 7 groups: baseline, MSC, and control administered groups, to be analyzed at 2, 3, and 4 weeks after GCI, respectively...
April 3, 2018: Brain Research
https://www.readbyqxmd.com/read/29623028/a-comparison-of-pathophysiology-in-humans-and-rodent-models-of-subarachnoid-hemorrhage
#9
REVIEW
Jenna L Leclerc, Joshua M Garcia, Matthew A Diller, Anne-Marie Carpenter, Pradip K Kamat, Brian L Hoh, Sylvain Doré
Non-traumatic subarachnoid hemorrhage (SAH) affects an estimated 30,000 people each year in the United States, with an overall mortality of ~30%. Most cases of SAH result from a ruptured intracranial aneurysm, require long hospital stays, and result in significant disability and high fatality. Early brain injury (EBI) and delayed cerebral vasospasm (CV) have been implicated as leading causes of morbidity and mortality in these patients, necessitating intense focus on developing preclinical animal models that replicate clinical SAH complete with delayed CV...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29614358/the-clinical-value-of-d-dimer-level-in-patients-with-non-aneurysmal-subarachnoid-hemorrhage
#10
Jianfeng Zheng, Chongjie Cheng, Chao Zhou, Hong Chen, Zongduo Guo, Xiaochuan Sun
OBJECTIVE: A growing number of non-aneurysmal subarachnoid hemorrhage (NaSAH) were found in clinical practice. However, the precise mechanisms in which D-dimer level is associated with clinical condition in patients with NaSAH remain unclear. But even more, the data assessing the risk of clinical course in the patients with NaSAH are scarce. Our objective was to investigate whether D-dimer levels correlated with complication and outcome in patients with NaSAH. METHODS: Between February 2013 and May 2017, 92 patients suffering from NaSAH were treated in our hospital...
March 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29611451/permeability-imaging-as-a-predictor-of-delayed-cerebral-ischemia-after-aneurysmal-subarachnoid-hemorrhage
#11
Jonathan J Russin, Axel Montagne, Francesco D'Amore, Shuhan He, Mark S Shiroishi, Robert C Rennert, Jena Depetris, Berislav V Zlokovic, William J Mack
Blood-brain barrier (BBB) dysfunction has been implicated in ischemic risk following aneurysmal subarachnoid hemorrhage (aSAH), but never directly imaged. We prospectively examined whether post-bleed day 4 dynamic contrast-enhanced magnetic resonance (DCE-MR) BBB permeability imaging could predict development of delayed cerebral ischemia (DCI). Global MR-derived BBB permeability ( Ktrans ) was significantly higher in aSAH patients who subsequently developed DCI (five patients; 2.28 ± 0.09 × 10-3 min-1 ) compared to those who experienced radiographic vasospasm only (three patients; 1...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29611441/juvenile-cerebral-ischemia-reveals-age-dependent-bdnf-trkb-signaling-changes-novel-mechanism-of-recovery-and-therapeutic-intervention
#12
Robert M Dietz, James E Orfila, Krista M Rodgers, Olivia P Patsos, Guiying Deng, Nicholas Chalmers, Nidia Quillinan, Richard J Traystman, Paco S Herson
Global ischemia in childhood often leads to poor neurologic outcomes, including learning and memory deficits. Using our novel model of childhood cardiac arrest/cardiopulmonary resuscitation (CA/CPR), we investigate the mechanism of ischemia-induced cognitive deficits and recovery. Memory is impaired seven days after juvenile CA/CPR and completely recovers by 30 days. Consistent with this remarkable recovery not observed in adults, hippocampal long-term potentiation (LTP) is impaired 7-14 days after CA/CPR, recovering by 30 days...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29607930/isosteviol-sodium-inhibits-astrogliosis-after-cerebral-ischemia-reperfusion-injury-in-rats
#13
Hao Zhang, Xiaoou Sun, Yanxiang Xie, Fang Tian, Hui Hu, Wen Tan
Previous reports have indicated that isosteviol sodium (STVNa) has neuroprotective effects against acute focal cerebral ischemia in rats; however, the exact underlying mechanisms and ideal treatment paradigm are not known. To find a reasonable method for STVNa administration and to determine its possible therapeutic mechanisms, we characterized the protective effects of single-dose and multiple-dose STVNa in cerebral ischemic/reperfusion (I/R) injury in rats. Single and multiple treatments with 10 mg/kg STVNa were administered intraperitoneally after injury to investigate its neuroprotective effects...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29600883/investigational-drugs-for-vasospasm-after-subarachnoid-hemorrhage
#14
Roberta T Tallarico, Michael A Pizzi, William D Freeman
Aneurysmal subarachnoid hemorrhage (aSAH) represents 3% of all strokes in the US. When the patient survives it can lead to permanent incapacity especially if the patient develops vasospasm. The vasospasm is a multifactorial disorder and can lead to delayed cerebral ischemia (DCI). Most of the drugs tested to treat vasospasm failed to improve outcome and the only exception is nimodipine. Areas covered: In this review, the authors describe the multifactorial process of vasospasm leading DCI after aSAH, discussing the treatments available based on the past and latest researches...
April 6, 2018: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29600342/hemodynamic-therapy-for-delayed-cerebral-ischemia-in-sah
#15
EDITORIAL
Michael N Diringer
No abstract text is available yet for this article.
March 29, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29588235/a-comparison-of-computed-tomography-based-scales-with-and-without-consideration-of-the-presence-or-absence-of-intraventricular-hemorrhage-in-patients-with-aneurysmal-subarachnoid-hemorrhage
#16
Tetsuji Inagawa, Masaaki Shibukawa, Toshikazu Hidaka
OBJECTIVE: There has been controversy as to whether intraventricular hemorrhage (IVH) after aneurysmal subarachnoid hemorrhage (SAH) contributes to angiographic cerebral vasospasm (aCV) and delayed cerebral ischemia (DCI). CT-based SAH scales that did and did not consider IVH were compared in terms of ability to predict aCV, DCI, and outcome. METHODS: We reviewed 390 patients with ruptured aneurysms who had been treated surgically by day 3 by the same surgeon (T...
March 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29572296/correction-to-amlexanox-inhibits-cerebral-ischemia-induced-delayed-astrocytic-high-mobility-group-box-1-release-and-subsequent-brain-damage
#17
(no author information available yet)
No abstract text is available yet for this article.
May 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29563892/incorporating-high-frequency-physiologic-data-using-computational-dictionary-learning-improves-prediction-of-delayed-cerebral-ischemia-compared-to-existing-methods
#18
Murad Megjhani, Kalijah Terilli, Hans-Peter Frey, Angela G Velazquez, Kevin William Doyle, Edward Sander Connolly, David Jinou Roh, Sachin Agarwal, Jan Claassen, Noemie Elhadad, Soojin Park
Purpose: Accurate prediction of delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) can be critical for planning interventions to prevent poor neurological outcome. This paper presents a model using convolution dictionary learning to extract features from physiological data available from bedside monitors. We develop and validate a prediction model for DCI after SAH, demonstrating improved precision over standard methods alone. Methods: 488 consecutive SAH admissions from 2006 to 2014 to a tertiary care hospital were included...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29560598/asymmetric-and-symmetric-dimethylarginines-are-markers-of-delayed-cerebral-ischemia-and-neurological-outcome-in-patients-with-subarachnoid-hemorrhage
#19
Daniel Appel, Miriam Seeberger, Edzard Schwedhelm, Patrick Czorlich, Alwin E Goetz, Rainer H Böger, Juliane Hannemann
BACKGROUND: Delayed cerebral ischemia (DCI) is the major cause of lethality and neuronal damage in patients who survived the primary subarachnoid hemorrhage (SAH). Asymmetric and symmetric dimethylarginines (ADMA and SDMA) inhibit nitric oxide production from L-arginine via distinct mechanisms. Elevated ADMA levels are associated with vasospasm after SAH. We aimed to study the time course of ADMA and SDMA in plasma and ventricular cerebrospinal fluid (CSF) and their associations with DCI and outcome...
March 20, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29556884/predicting-delayed-cerebral-ischemia-after-subarachnoid-hemorrhage-using-physiological-time-series-data
#20
Soojin Park, Murad Megjhani, Hans-Peter Frey, Edouard Grave, Chris Wiggins, Kalijah L Terilli, David J Roh, Angela Velazquez, Sachin Agarwal, E Sander Connolly, J Michael Schmidt, Jan Claassen, Noemie Elhadad
To develop and validate a prediction model for delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) using a temporal unsupervised feature engineering approach, demonstrating improved precision over standard features. 488 consecutive SAH admissions from 2006 to 2014 to a tertiary care hospital were included. Models were trained on 80%, while 20% were set aside for validation testing. Baseline information and standard grading scales were evaluated: age, sex, Hunt Hess grade, modified Fisher Scale (mFS), and Glasgow Coma Scale (GCS)...
March 20, 2018: Journal of Clinical Monitoring and Computing
keyword
keyword
116797
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"