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https://www.readbyqxmd.com/read/29353427/application-of-three-dimensional-printing-in-laparoscopic-dissection-to-facilitate-d3-lymphadenectomy-for-right-colon-cancer
#1
A Garcia-Granero, L Sánchez-Guillén, D Fletcher-Sanfeliu, B Flor-Lorente, M Frasson, J Sancho Muriel, E Alvarez Serrado, G Pellino, I Grifo Albalat, F Giner, M J Roca Estelles, P Esclapez Valero, E Garcia-Granero
No abstract text is available yet for this article.
January 20, 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29353314/robot-assisted-post-chemotherapy-retroperitoneal-lymph-node-dissection-in-germ-cell-tumor-is-the-single-docking-with-lateral-approach-relevant
#2
C Overs, J B Beauval, L Mourey, P Rischmann, M Soulié, M Roumiguié, Nicolas Doumerc
INTRODUCTION: Surgical treatment of post-chemotherapy residual mass of germ cell tumor (GCT) may be performed in various techniques. We assess the feasibility, safety, and efficacy of single-docking with lateral approach robot-assisted retroperitoneal lymph node dissection (R-RPLND) in residual mass of GCT in our center. MATERIALS AND METHODS: A retrospective review of patients undergoing R-RPLND for residual mass of CGT was performed between January 2014 and April 2017...
January 20, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29353021/phosphoproteomics-unveils-stable-energy-supply-as-key-to-flooding-tolerance-in-kandelia-candel
#3
Dezhuo Pan, Lingxia Wang, Fanglin Tan, Si Lu, Xiaojie Lv, Madiha Zaynab, Chi-Lien Cheng, Yakubu Saddeeq Abubakar, Shipin Chen, Wei Chen
The mangrove Kandelia candel (L.) Druce experiences daily flooding cycles. To explore the molecular mechanism underlying the physiological adaptation of K. candel to flooding, the potential role of protein phosphorylation in flooding responses was investigated by a large-scale quantitative phosphoproteomic analysis using isobaric tag for relative and absolute quantitation. Total 2141 unique phosphopeptides and 2603 non-redundant phosphorylation sites were identified from 1516 phosphoproteins in K. candel leaves...
January 15, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29352971/magnetic-anchor-guided-endoscopic-submucosal-dissection-for-gastric-lesions-with-video
#4
Ippei Matsuzaki, Masashi Hattori, Ken Hirose, Masaya Esaki, Masakatsu Yoshikawa, Takio Yokoi, Makoto Kobayashi, Ryoji Miyahara, Yoshiki Hirooka, Hidemi Goto
BACKGROUND AND AIM: The feasibility of magnetic anchor-guided endoscopic submucosal dissection (MAG-ESD) using a neodymium magnet for gastric lesions has not been clarified. The aim of study was to evaluate the feasibility of MAG-ESD using neodymium magnets while treating gastric lesions. METHODS: This prospective trial was conducted at the Yamashita Hospital. The MAG-ESD was performed for 50 gastric lesions using an insulated-tip knife. The magnetic anchor consisted of an internal neodymium magnet attached to a hemoclip with 3-0 silk...
January 15, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29352673/chest-pain-in-a-young-female
#5
Paul S Basel, Daniel Reschke, Michael D April
Acute Coronary Syndrome (ACS) is a common diagnosis in the emergency department (ED), the most severe manifestation of which is ST elevation on electrocardiogram (ECG). ST elevation reflects obstruction of flow through the coronary arteries, most commonly due to coronary atherosclerotic plaque rupture. However, alternative causes of coronary obstruction causing ST elevation are possible. Spontaneous coronary artery dissection (SCAD) is an unusual cause of ST elevation in ED patients which providers may encounter in patients without traditional atherosclerosis risk factors...
January 11, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29352630/surgical-damage-to-the-lymphatic-system-promotes-tumor-growth-via-impaired-adaptive-immune-response
#6
Yoshiyuki Nakamura, Yasuhiro Fujisawa, Naoko Okiyama, Rei Watanabe, Ryota Tanaka, Yosuke Ishitsuka, Hideaki Tahara, Manabu Fujimoto
BACKGROUND: Both lymph nodes (LNs) and lymphatic channels from primary sites to regional LNs are critical for initiation of adaptive immunity. However, as LNs are common metastatic sites in skin cancers, LN biopsies or dissections are frequently performed. In addition, reconstructive skin flaps after tumor resection may damage lymphatic flow from primary sites to regional LNs. OBJECTIVE: This study was designed to investigate the effect on tumor progression by such surgeries...
December 29, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29352595/axillary-tumour-burden-in-women-with-one-abnormal-node-on-ultrasound-compared-to-women-with-multiple-abnormal-nodes
#7
S Puri, N Sharma, R G Newcombe, M Kaushik, M Al-Attar, S Pascaline, M Hajaj, M G Wallis, B Elsberger, A Goyal
AIM: To determine if the number of abnormal nodes seen on preoperative axillary ultrasound (AUS) is a predictor of the number of positive nodes at histology for women with needle-biopsy-proven positive nodes. MATERIALS AND METHODS: This prospective multicentre cohort study included consecutive patients with early breast cancer who had needle-biopsy-proven positive nodes on AUS and underwent axillary lymph node dissection (ALND) between October 2015 and July 2016...
January 15, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29352567/asymptomatic-ascending-aorta-aneurysm-with-severe-aortic-regurgitation-caused-by-multiple-intimal-medial-tears-unassociated-with-aortic-dissection
#8
Carlos E Velasco, Helen Hashemi, Christina P Roullard, Juan Machannaford, William C Roberts
A 62-year-old man was found to have an asymptomatic ascending aortic aneurysm (6.6 cm) associated with severe aortic regurgitation. Operative resection of the wall of the aneurysm disclosed its cause to be multiple healed intimal-medial tears without dissection involving a previously normal aorta. The concept of an intimal-medial tear unassociated with aortic dissection is a poorly recognized entity and these tears appear to be asymptomatic and after the aortic tearing lead to aneurysmal formation.
December 12, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29352442/laparoscopic-and-endoscopic-cooperative-surgery-versus-endoscopic-submucosal-dissection-for-the-treatment-of-low-risk-tumors-of-the-duodenum
#9
Toshiyasu Ojima, Mikihito Nakamori, Masaki Nakamura, Keiji Hayata, Masahiro Katsuda, Katsunari Takifuji, Hiroki Yamaue
BACKGROUND: There have been no comparative studies of endoscopic submucosal dissection (ESD) and laparoscopic and endoscopic cooperative surgery (LECS) for patients with duodenal tumors regarding surgical outcomes. The aim of this study is to compare the safety and feasibility of short-term surgical outcomes of ESD and LECS for patients with low-risk tumors of the duodenum. METHODS: This was a single-center retrospective study of 68 consecutive patients with low-risk tumors of the duodenum who received surgical treatments...
January 19, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29352348/metarhizium-anisopliae-s-l-modulation-of-lipid-metabolism-during-tick-infection-is-independent-of-ampk-and-erk-pathways
#10
Fillipe A Sá, Caio Junior B Coutinho-Rodrigues, Isabele C Angelo, Jéssica P Fiorotti, Georgia C Atella, Vânia Rita E P Bittencourt, Mário Alberto C Silva-Neto
Despite the importance of fat body in metabolism of arthropods, studies in ticks are scarce. This study evaluated the lipid composition and activation of extracellular signal-regulated protein kinase (ERK) and AMP-activated protein kinase (AMPK) enzymes in Rhipicephalus microplus fat body after infection with different isolates of the fungus Metarhizium anisopliae sensu lato (Metschnikoff, 1879) Sorokin, 1883. The isolates CG 32, GC 112, GC 148, GC 347, and GC 629 were inoculated as viable or non-viable conidia in the ticks...
January 19, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29352338/predictive-factors-for-lymph-node-metastasis-in-submucosal-invasive-colorectal-carcinoma-a-new-proposal-of-depth-of-invasion-for-radical-surgery
#11
Jeonghee Han, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim
BACKGROUND: Patients with lymph node metastasis (LNM) in submucosal invasive colorectal carcinoma (SM cancer) require additional surgical treatment after endoscopic dissection. However, because additional radical resection after endoscopic local resection may be unnecessary for cases without LNM, more specific criteria are required in order to diminish the incidence of further radical resection after endoscopic dissection. METHODS: A total of 492 patients with biopsy-proven SM cancer who underwent curative surgery between January 2008 and December 2012 were collected and were divided into LNM group and no LNM group...
January 19, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29352242/ptre-seq-reveals-mechanism-and-interactions-of-rna-binding-proteins-and-mirnas
#12
Kyle A Cottrell, Hemangi G Chaudhari, Barak A Cohen, Sergej Djuranovic
RNA binding proteins (RBP) and microRNAs (miRNAs) often bind sequences in 3' untranslated regions (UTRs) of mRNAs, and regulate stability and translation efficiency. With the identification of numerous RBPs and miRNAs, there is an urgent need for new technologies to dissect the function of the cis-acting elements of RBPs and miRNAs. We describe post-transcriptional regulatory element sequencing (PTRE-seq), a massively parallel method for assaying the target sequences of miRNAs and RBPs. We use PTRE-seq to dissect sequence preferences and interactions between miRNAs and RBPs...
January 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/29352180/relationship-between-serum-cortisol-level-and-degree-of-false-lumen-thrombosis-in-patients-with-uncomplicated-type-b-aortic-dissection
#13
Yani Wu, Yudong Sun, Xiaolong Wei, Lei Zhang, Tonglei Han, Zhiqing Zhao, Jian Zhou, Zaiping Jing
Partial thrombosis of the false lumen in uncomplicated type B aortic dissection (uTBAD) is associated with an increased late mortality risk. Whether the serum cortisol level can affect false lumen thrombosis in patients with uTBAD has not been well characterized. This study was performed on 87 patients with uTBAD. A curve-fitting method was used to analyze the relationship between serum cortisol and partial thrombosis of false lumen. Univariate and multivariate logistic regression analyses were used to identify false lumen partial thrombosis-associated serum cortisol...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352023/monoamine-abnormalities-in-the-sapap3-knockout-model-of-obsessive-compulsive-disorder-related-behaviour
#14
Jesse Wood, Zoe LaPalombara, Susanne E Ahmari
Obsessive-compulsive disorder (OCD) is a leading cause of illness-related disability, but the neural mechanisms underlying OCD symptoms are unclear. One potential mechanism of OCD pathology is monoamine dysregulation. Because of the difficulty of studying monoamine signalling in patients, animal models offer a viable alternative to understanding this aspect of OCD pathophysiology. We used HPLC to characterize post-mortem monoamine levels in lateral orbitofrontal cortex (OFC), medial OFC, medial prefrontal cortex and dorsal and ventral striatum of SAPAP-3 knockout (KO) mice, a well-validated model of compulsive-like behaviours in OCD...
March 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29352019/opposing-roles-of-tgf%C3%AE-and-bmp-signaling-in-prostate-cancer-development
#15
Xin Lu, Eun-Jung Jin, Xi Cheng, Shan Feng, Xiaoying Shang, Pingna Deng, Shan Jiang, Qing Chang, Sharif Rahmy, Seema Chaudhary, Xuemin Lu, Ren Zhao, Y Alan Wang, Ronald A DePinho
SMAD4 constrains progression of Pten-null prostate cancer and serves as a common downstream node of transforming growth factor β (TGFβ) and bone morphogenetic protein (BMP) pathways. Here, we dissected the roles of TGFβ receptor II (TGFBR2) and BMP receptor II (BMPR2) using a Pten-null prostate cancer model. These studies demonstrated that the molecular actions of TGFBR2 result in both SMAD4-dependent constraint of proliferation and SMAD4-independent activation of apoptosis. In contrast, BMPR2 deletion extended survival relative to Pten deletion alone, establishing its promoting role in BMP6-driven prostate cancer progression...
December 1, 2017: Genes & Development
https://www.readbyqxmd.com/read/29351850/systematic-gene-to-phenotype-arrays-a-high-throughput-technique-for-molecular-phenotyping
#16
Philipp A Jaeger, Lilia Ornelas, Cameron McElfresh, Lily R Wong, Randolph Y Hampton, Trey Ideker
We have developed a highly parallel strategy, systematic gene-to-phenotype arrays (SGPAs), to comprehensively map the genetic landscape driving molecular phenotypes of interest. By this approach, a complete yeast genetic mutant array is crossed with fluorescent reporters and imaged on membranes at high density and contrast. Importantly, SGPA enables quantification of phenotypes that are not readily detectable in ordinary genetic analysis of cell fitness. We benchmark SGPA by examining two fundamental biological phenotypes: first, we explore glucose repression, in which SGPA identifies a requirement for the Mediator complex and a role for the CDK8/kinase module in regulating transcription...
January 18, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29351773/treatment-of-long-segment-barrett-s-adenocarcinoma-by-complete-circular-endoscopic-submucosal-dissection-a-case-report
#17
Miki Kaneko, Akira Mitoro, Motoyuki Yoshida, Masayoshi Sawai, Yasushi Okura, Masanori Furukawa, Tadashi Namisaki, Kei Moriya, Takemi Akahane, Hideto Kawaratani, Mitsuteru Kitade, Kousuke Kaji, Hiroaki Takaya, Yasuhiko Sawada, Kenichiro Seki, Shinya Sato, Tomomi Fujii, Junichi Yamao, Chiho Obayashi, Hitoshi Yoshiji
BACKGROUND: We present the first description of en bloc endoscopic submucosal dissection (ESD) for total circumferential Barrett's adenocarcinoma, predominantly of the long-segment Barrett's esophagus (LSBE), with a 2-year follow-up and management strategies for esophageal stricture prevention. CASE PRESENTATION: A 59-year-old man was diagnosed with LSBE and Barrett's adenocarcinoma by esophagogastroduodenoscopy (EGD). A 55-mm-long circumferential tumor was completely resected by ESD...
January 19, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29351699/endoscopic-submucosal-tunnel-dissection-for-early-squamous-cell-carcinoma-of-the-esophagus
#18
Iman Andalib, Enad Dawod, Monica Saumoy, Melanie Johncilla, Amy Tyberg, Michel Kahaleh
No abstract text is available yet for this article.
January 19, 2018: Endoscopy
https://www.readbyqxmd.com/read/29351678/endoscopic-transcranial-duraplasty-for-rhinoliquorrhea-a-cadaveric-study
#19
Andrea Bartoli, Jean H Fasel, Karl Schaller, Max Jägersberg
BACKGROUND: Repair of the anterior skull base for cerebrospinal fluid leak requires either endoscopic endonasal approach or open transcranial approach. OBJECTIVE: To present a less invasive surgical procedure for sealing of the entire anterior fossa floor for traumatic rhinoliquorrhea. METHODS: Cadaver study in 3 head specimens. Endoscopic placement of a furled bovine pericardial patch bilaterally along the sphenoid ridge and planum in guidewire technique...
February 1, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29351643/genetic-dissection-of-the-fuzzless-seed-trait-in-gossypium-barbadense
#20
Qian-Hao Zhu, Yuman Yuan, Warwick Stiller, Yinhua Jia, Pengpeng Wang, Zhaoe Pan, Xiongming Du, Danny Llewellyn, Iain Wilson
Cotton fibres are single-celled trichomes arising from the epidermal cells of the seed coat and may be either long (lint) or very short (fuzz). The dominant fuzzless N1 of Gossypium hirsutum is a defective allele of the At-subgenome homoeolog of MYB25-like, but the genetic components underlying the recessive fuzzless trait from G. barbadense (Gb) are unknown. We have identified five genetic loci, including a major contributing locus containing MYB25-like_Dt, associated with Gb fuzzless seeds based on genotyping of fuzzy and fuzzless near isogenic lines (NILs) from an interspecies cross (G...
January 17, 2018: Journal of Experimental Botany
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