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https://www.readbyqxmd.com/read/29858973/effects-of-formulation-variables-on-lung-dosimetry-of-albuterol-sulfate-suspension-and-beclomethasone-dipropionate-solution-metered-dose-inhalers
#1
Jeffry D Schroeter, Poonam Sheth, Anthony J Hickey, Bahman Asgharian, Owen T Price, Jay T Holt, Denise S Conti, Bhawana Saluja
The performance of pressurized metered dose inhalers (MDIs) is affected by formulation and device variables that impact delivered dose, aerodynamic particle size distribution, and consequently lung deposition and therapeutic effect. Specific formulation variables of relevance to two commercially available products-Proventil® HFA [albuterol sulfate (AS) suspension] and Qvar® [beclomethasone dipropionate (BDP) solution]-were evaluated to determine their influence on key performance attributes measured experimentally with in vitro cascade impaction studies...
June 1, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29776851/treatment-planning-dose-accuracy-improvement-in-the-presence-of-dental-implants
#2
Holly M Parenica, John R Ford, Panayiotis Mavroidis, Ying Li, Nikos Papanikolaou, Sotirios Stathakis
Streaking artifacts in computed tomography (CT) scans caused by metallic dental implants (MDIs) can lead to inaccuracies in dose calculations. This study quantifies and compares the effect of MDIs on dose distributions using the collapsed cone convolution superposition (CCCS) and Monte Carlo (MC) algorithms, with and without correcting for the density of the MDIs. Ion chamber measurements were taken to test the ability of the algorithms in Pinnacle3 and Monaco to calculate dose near high-Z materials. Nine previously treated patients with head and neck cancer were included in this study...
May 15, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29661916/sustained-reduction-in-severe-hypoglycemia-in-adults-with-type-1-diabetes-complicated-by-impaired-awareness-of-hypoglycemia-2-year-follow-up-in-the-hypocompass-randomized-clinical-trial
#3
Stuart A Little, Jane Speight, Lalantha Leelarathna, Emma Walkinshaw, Horng Kai Tan, Anita Bowes, Alexandra Lubina-Solomon, Thomas J Chadwick, Deborah D Stocken, Catherine Brennand, Sally M Marshall, Ruth Wood, David Kerr, Daniel Flanagan, Simon R Heller, Mark L Evans, James A M Shaw
OBJECTIVE: Severe hypoglycemia is a feared complication of type 1 diabetes; yet, few trials have targeted prevention using optimized self-management (educational, therapeutic, and technological support). We aimed to investigate whether improved awareness and reduced severe hypoglycemia, achieved during an intensive randomized clinical trial (RCT), were sustained after return to routine care. RESEARCH DESIGN AND METHODS: Ninety-six adults with type 1 diabetes (29 ± 12 years' duration) and impaired awareness of hypoglycemia at five U...
April 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29574787/multiple-drug-intolerance-syndrome-and-multiple-drug-allergy-syndrome-epidemiology-and-associations-with-anxiety-and-depression
#4
Kimberly G Blumenthal, Yu Li, Warren W Acker, Yuchiao Chang, Aleena Banerji, Sharmin Ghaznavi, Carlos A Camargo, Li Zhou
BACKGROUND: The epidemiology of Multiple Drug Intolerance Syndrome (MDIS) and Multiple Drug Allergy Syndrome (MDAS) are poorly characterized. We used electronic health record (EHR) data to describe prevalences of MDIS and MDAS and to examine associations with anxiety and depression. METHODS: Patients with ≥3 outpatient encounters at Partners HealthCare System from 2008-2015 were included. MDIS patients had intolerances to ≥3 drug classes and MDAS patients had hypersensitivities to ≥2 drug classes...
March 25, 2018: Allergy
https://www.readbyqxmd.com/read/29559538/patient-satisfaction-with-inhaled-medication-for-asthma
#5
Ashutosh N Aggarwal, Raman Kumari, Sandeep Grover
BACKGROUND: We sought to compare treatment satisfaction with inhaled medications among asthmatics using a metered-dose inhaler (MDI) or a dry-powder inhaler (DPI), and to correlate satisfaction with treatment adherence, pulmonary function, and airway inflammation. METHODS: Spirometry, fraction of expired nitric oxide (FENO ), and asthma control were assessed in 200 adult subjects with asthma (69 men, 131 women) using MDI or DPI. Treatment satisfaction with inhaled therapy was assessed with the Treatment Satisfaction Questionnaire for Medication (TSQM) in 4 domains: Effectiveness, Side Effects, Convenience, and Global Satisfaction...
March 20, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29448265/short-term-postoperative-pain-and-swelling-associated-with-mini-and-standard-size-implants-in-the-same-patients
#6
Ines Kovačić, Sanja Peršić, Josip Kranjčić, Visar Disha, Ksenija Rener-Sitar, Asja Čelebić
PURPOSE: To assess short-term postoperative pain and swelling after insertion of mini dental implants (MDI) and standard-size implants (SSI) in the same patients at different times. MATERIALS AND METHODS: A convenience sample of 42 patients (22 females, 20 males; 58 to 73 years old) participated. Half of the participants received MDIs first, and the other half received SSIs first. Self-perceived pain and swelling at 1, 3, 5, 7, and 10 days postoperative were assessed using a 0-10 visual analog scale...
February 15, 2018: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29409620/necrotizing-enterocolitis-as-a-prognostic-factor-for-the-neurodevelopmental-outcome-of-preterm-infants-match-control-study-after-2years
#7
Antje Allendorf, Ruth Dewitz, Joy Weber, Shahrzad Bakthiar, Rolf Schloesser, Udo Rolle
PURPOSE: Necrotizing enterocolitis (NEC) in very low birth weight infants is a risk factor for developmental delay. To our knowledge, there are no studies published investigating the neurodevelopmental outcome of patients with NEC comparing surgically treated and conservatively treated patients versus match paired controls. The aim of this retrospective case control study was to measure the neurodevelopmental outcome of patients with NEC who were treated surgically or conservatively METHODS: All patients were identified, who have been diagnosed with NEC (ICD-10 code, P77) born between 2006 and 2013...
January 31, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29398766/missing-the-unhealthy-examining-empirical-validity-of-material-deprivation-indices-mdis-using-a-partial-criterion-variable
#8
Selcuk Beduk
This study investigates the empirical validity of the material deprivation indices (MDIs) using a partial criterion variable, namely UHCNIR (unmet health care need due to inadequate resources). This alternative approach helps to assess absolute validity (Type I and II errors) and sources of error in the measurement of poverty for a specific aspect of poverty (in this case inability to receive adequate health care due to affordability problems). A simple mismatch analysis identifies a sizable group, around 1% of the adult EU population, missed by MDIs despite being in UHCNIR...
2018: Social Indicators Research
https://www.readbyqxmd.com/read/29396389/mobile-diabetes-intervention-study-of-patient-engagement-and-impact-on-blood-glucose-mixed-methods-analysis
#9
Charlene Connolly Quinn, Erin C Butler, Krystal K Swasey, Michelle D Shardell, Michael D Terrin, Erik A Barr, Ann L Gruber-Baldini
BACKGROUND: Successful treatment of diabetes includes patient self-management behaviors to prevent or delay complications and comorbid diseases. On the basis of findings from large clinical trials and professional guidelines, diabetes education programs and health providers prescribe daily regimens of glucose monitoring, healthy eating, stress management, medication adherence, and physical activity. Consistent, long-term commitment to regimens is challenging. Mobile health is increasingly being used to assist patients with lifestyle changes and self-management behaviors between provider visits...
February 2, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29383616/assessment-of-snaith-hamilton-pleasure-scale-shaps-the-dimension-of-anhedonia-in-italian-healthy-sample
#10
Iolanda Martino, Gabriella Santangelo, Daniela Moschella, Luana Marino, Rocco Servidio, Antonio Augimeri, Angela Costabile, Giovanni Capoderose, Antonio Cerasa
The Snaith-Hamilton Pleasure Scale (SHAPS) is a rapid screening battery created for assessing the presence of anhedonia, namely the inability to experience pleasure. Although, this symptom has widely been investigated in clinical settings, individual differences in anhedonia are also present in healthy population. The aim of present study was to validate the translated Italian version of this test. One thousand six hundred ninety-seven consecutive healthy subjects (55% female) of different ages (age 18-82 years) underwent SHAPS...
April 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29340354/implant-mandibular-overdentures-retained-by-immediately-loaded-implants-a-1-year-randomized-trial-comparing-patient-based-outcomes-between-mini-dental-implants-and-standard-sized-implants
#11
Kostas Zygogiannis, Irene Ha Aartman, Daniel Wismeijer
PURPOSE: The aim of this 1-year randomized trial was to determine the stability and the magnitude of the effect of converting patients' conventional mandibular dentures to implant overdentures (IODs) on their satisfaction and oral health-related quality of life (OHRQoL). The IODs were retained either with two immediately loaded interconnected standard-diameter implants or with four immediately loaded mini dental implants (MDIs). MATERIALS AND METHODS: Fifty completely edentulous subjects complaining about insufficient retention of their mandibular dentures were randomly assigned to two groups; 25 patients received IODs retained with four MDIs and 25 patients received IODs retained with two standard-sized tissue level (STL) interconnected implants...
January 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29287778/structural-evidence-for-a-fatty-acid-independent-myotoxic-mechanism-for-a-phospholipase-a-2-like-toxin
#12
Guilherme H M Salvador, Juliana I Dos Santos, Rafael J Borges, Marcos R M Fontes
The myotoxic mechanism for PLA2 -like toxins has been proposed recently to be initiated by an allosteric change induced by a fatty acid binding to the protein, leading to the alignment of the membrane docking site (MDoS) and membrane disrupting site (MDiS). Previous structural studies performed by us demonstrated that MjTX-II, a PLA2 -like toxin isolated from Bothrops moojeni, presents a different mode of ligand-interaction caused by natural amino acid substitutions and an insertion. Herein, we present four crystal structures of MjTX-II, in its apo state and complexed with fatty acids of different lengths...
March 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29212836/inhaler-technique-does-age-matter-a-systematic-review
#13
REVIEW
Sarah Barbara, Vicky Kritikos, Sinthia Bosnic-Anticevich
Poor inhaler technique and inferior asthma outcomes are evident in older adults. Reviews comparing metered dose inhaler (MDI) and dry powder inhaler (DPI) techniques across older adults and younger cohorts are scarce. This systematic review aimed to determine whether differences exist between such cohorts with regards to the number and type of MDI and DPI errors made. A systematic literature search was conducted in Embase, Medline and PubMed from July 1 to December 31, 2016. Studies were selected in accordance with preset inclusion criteria, relevant data were extracted, and quality was assessed with validated checklists...
December 31, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29140382/implant-mandibular-overdentures-retained-by-immediately-loaded-implants-a-1-year-randomized-trial-comparing-the-clinical-and-radiographic-outcomes-between-mini-dental-implants-and-standard-sized-implants
#14
RANDOMIZED CONTROLLED TRIAL
Kostas Zygogiannis, Irene Ha Aartman, Azin Parsa, Ali Tahmaseb, Daniel Wismeijer
PURPOSE: The aim of this 1-year randomized trial was to evaluate and compare the clinical and radiographic performance of four immediately loaded mini dental implants (MDIs) and two immediately loaded standard-sized tissue-level (STL) implants, placed in the interforaminal region of the mandible and used to retain mandibular overdentures (IODs) in completely edentulous patients. MATERIALS AND METHODS: A total of 50 completely edentulous patients wearing conventional maxillary dentures and complaining about insufficient retention of their mandibular dentures were divided into two groups; 25 patients received four MDIs and 25 patients received two STL implants...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28937845/pharmacokinetics-of-beclomethasone-dipropionate-delivered-by-breath-actuated-inhaler-and-metered-dose-inhaler-in-healthy-subjects
#15
Calvin J Small, Michael Gillespie
BACKGROUND: Breath-actuated inhalers (BAIs) eliminate the need for hand-breath coordination required of pressurized metered-dose inhalers (MDIs). This pharmacokinetic study compared systemic exposure following beclomethasone dipropionate delivery through BAI versus MDI. METHODS: This open-label, three-period crossover, single-dose study randomized healthy subjects aged 18-45 years (N = 72) to 1 of 6 treatment sequences containing beclomethasone dipropionate BAI 160 mcg (40 mcg/inhalation, 4 inhalations), beclomethasone dipropionate BAI 320 mcg (80 mcg/inhalation, 4 inhalations), and beclomethasone dipropionate MDI 320 mcg (80 mcg/inhalation, 4 inhalations)...
September 22, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28902790/impact-of-treatments-on-diabetic-control-and-gastrointestinal-symptoms-after-total-pancreatectomy
#16
Maarten R Struyvenberg, Zhi Ven Fong, Camilia R Martin, Jennifer F Tseng, Thomas E Clancy, Carlos Fernández-Del Castillo, Hanna J Tillman, Melena D Bellin, Steven D Freedman
OBJECTIVES: The aims of this study were to compare the safety, efficacy, and patients' quality of life with continuous subcutaneous insulin infusion (CSII) versus multiple daily injections (MDIs) in type 3c diabetes mellitus (T3cDM) following total pancreatectomy (TP) and pancreatic enzyme usage. METHODS: Thirty-nine patients with T3cDM (18 CSII patients vs 21 MDI patients) who underwent TP between 2000 and 2016 at 3 Harvard-affiliated hospitals and the University of Minnesota returned prospectively obtained questionnaires examining quality of life and both endocrine and exocrine pancreatic functions...
October 2017: Pancreas
https://www.readbyqxmd.com/read/28880704/sample-size-estimation-for-the-u-s-food-and-drug-administration-s-in-vitro-population-bioequivalence-test-of-dpis-mdis-nasal-sprays-and-nebules
#17
Anders Fuglsang
No abstract text is available yet for this article.
April 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28868133/achieving-good-adherence-to-inhaled-corticosteroids-after-weighing-canisters-of-asthmatic-children
#18
Wantida Chuenjit, Vorapan Engchuan, Araya Yuenyongviwat, Pasuree Sangsupawanich
Background: The metered-dose inhalers (MDIs) currently available for inhaled corticosteroid delivery do not offer an integrated dose counter; therefore, it is difficult to evaluate adherence of patients. The present authors developed a linear regression equation using canister weight to calculate the number of doses actuated from the MDIs. This study aimed to assess medical adherence after the integration of regular weighing of the canisters into the routine service.  Methods: A cohort study was carried out between May 2013 and April 2014...
2017: F1000Research
https://www.readbyqxmd.com/read/28816711/multiple-drug-intolerant-hypertension
#19
Andrea E Neculau, Liliana M Rogozea, Oana Andreescu, Loredana Jinga, Eleonora A Dinu, Diana Tint
CLINICAL FEATURES: The term multiple drug intolerance (MDI) is attributed to patients who experience adverse drug reactions to more than 3 different classes of medication without a known immunological mechanism. A special attention should be given to multiple drug-intolerant hypertension (MDI-HTN) that is a cause of drop out from treatment and consequent poor blood pressure control. Patients with MDIs account for 2%-5% of all population. The patient we present is a 63-year-old man with third-degree hypertension identified with intolerance to drugs from 4 major classes of antihypertensive medication...
September 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/28774201/patterns-of-use-of-dry-powder-inhalers-versus-pressurized-metered-dose-inhalers-devices-in-adult-patients-with-chronic-obstructive-pulmonary-disease-or-asthma-an-observational-comparative-study
#20
Wijdan H Ramadan, Aline T Sarkis
Numerous patients with chronic obstructive pulmonary disease (COPD) and asthma do not use inhaler devices properly, which can contribute to poor disease control. The objective of this study is to assess the technical and safety use of dry powder inhalers (DPIs) versus pressurized metered-dose inhalers (MDIs) in adult patients with COPD or asthma in Lebanon. A concurrent, prospective comparative observational study was conducted at one hospital and 15 community pharmacies in Lebanon. Over a period of 18 months, 246 questionnaires were filled...
August 2017: Chronic Respiratory Disease
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