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https://www.readbyqxmd.com/read/28931206/metabolic-engineering-a-yeast-to-produce-astaxanthin
#1
Yu-Ju Lin, Jui-Jen Chang, Hao-Yeh Lin, Caroline Thia, Yi-Ying Kao, Chieh-Chen Huang, Wen-Hsiung Li
In this study, an astaxanthin-biosynthesis Kluyveromyces marxianus strain Sm23 was first constructed, which could produce 31µg/g DCW astaxanthin. Then, repeated genome integration of the key astaxanthin biosynthesis genes Hpchyb and bkt was done to increase gene copy number and astaxanthin yield. Four improved strains were obtained and the yield of astaxanthin and the total yield of carotenoids in a strain increased with the copy numbers of Hpchyb and bkt. To improve the yield further, the gene Hpchyb from Haematococcus pluvialis was modified by site-directed mutagenesis to increase the enzyme efficiency or/and to prevent the heterologous protein degradation by ubiquitination...
July 23, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28930152/proteomic-analysis-of-the-chlorophyta-dunaliella-new-strain-al-1-revealed-global-changes-of-metabolism-during-high-carotenoid-production
#2
Faten Ben Amor, Fatma Elleuch, Hajer Ben Hlima, Matthieu Garnier, Bruno Saint-Jean, Mohamed Barkallah, Chantal Pichon, Slim Abdelkafi, Imen Fendri
The green microalgae Dunaliella genus is known for the production of high added value molecules. In this study, strain AL-1 was isolated from the Sebkha of Sidi El Hani (Sousse, Tunisia). This isolate was identified both morphologically and genetically via 18S rRNA gene sequence as a member of the genus Dunaliella. Strain AL-1 was found to be closely related to Dunaliella salina, Dunaliella quartolecta and Dunaliella polymorpha with more than 97% similarity. Response surface methodology was used to maximize carotenoid production by strain AL-1 by optimizing its growth conditions...
September 20, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28929465/erratum-to-interaction-of-the-signaling-state-analog-and-the-apoprotein-form-of-the-orange-carotenoid-protein-with-the-fluorescence-recovery-protein
#3
Marcus Moldenhauer, Nikolai N Sluchanko, Neslihan N Tavraz, Cornelia Junghans, David Buhrke, Mario Willoweit, Leonardo Chiappisi, Franz-Josef Schmitt, Vladana Vukojević, Evgeny A Shirshin, Vladimir Y Ponomarev, Vladimir Z Paschenko, Michael Gradzielski, Eugene G Maksimov, Thomas Friedrich
In Fig. 1a in the original article, the amino acid side chains were incorrectly labeled in the structure representation of the orange carotenoid protein (OCP). The corrected figure is printed in this erratum.
September 19, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28929276/the-photosynthetic-responses-to-stocking-depth-and-algal-mat-density-in-the-farmed-seaweed-gracilaria-lemaneiformis-gracilariales-rhodophyta
#4
Heng Jiang, Dinghui Zou, Weizhou Chen, Yufeng Yang
The branches and mass of Gracilaria lemaneiformis increase with growth season, and the thalli sink to deeper depths with increasing biomass density during maricultivation. The changing depth and algal mat density may affect the physiology of the algae. In the present study, the photosynthetic behaviors regarding different biomass densities in G. lemaneiformis thalli collected from different stocking depths were determined, to examine how photosynthesis of this farmed alga was affected by the growth depths and algal mat densities...
September 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28929006/a-comparison-of-the-morphological-and-biochemical-characteristics-of-chlorella-sorokiniana-and-chlorella-zofingiensis-cultured-under-photoautotrophic-and-mixotrophic-conditions
#5
Siti Nor Ani Azaman, Norio Nagao, Fatimah M Yusoff, Sheau Wei Tan, Swee Keong Yeap
The responses of two species of microalgae, Chlorella sorokiniana and Chlorella zofingiensis, were compared regarding their morphological and biochemical properties under photoautotrophic and mixotrophic conditions. These microalgae were cultured under both conditions, and their crude ethanolic extracts were examined for their pigment and total phenolic contents. In addition, the microalgae's antioxidant activities were determined using a DPPH radical scavenging assay and a ferric reducing antioxidant power (FRAP) assay...
2017: PeerJ
https://www.readbyqxmd.com/read/28928905/fucoxanthin-a-marine-carotenoid-attenuates-%C3%AE-amyloid-oligomer-induced-neurotoxicity-possibly-via-regulating-the-pi3k-akt-and-the-erk-pathways-in-sh-sy5y-cells
#6
Jiajia Lin, Jie Yu, Jiaying Zhao, Ke Zhang, Jiachen Zheng, Jialing Wang, Chunhui Huang, Jingrong Zhang, Xiaojun Yan, William H Gerwick, Qinwen Wang, Wei Cui, Shan He
Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by neurofibrillary tangles, synaptic impairments, and loss of neurons. Oligomers of β-amyloid (Aβ) are widely accepted as the main neurotoxins to induce oxidative stress and neuronal loss in AD. In this study, we discovered that fucoxanthin, a marine carotenoid with antioxidative stress properties, concentration dependently prevented Aβ oligomer-induced increase of neuronal apoptosis and intracellular reactive oxygen species in SH-SY5Y cells...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28928521/comparative-analysis-of-carotenoid-content-in-momordica-cochinchinensis-cucurbitaceae-collected-from-australia-thailand-and-vietnam
#7
Dilani Wimalasiri, Robert Brkljača, Terrence J Piva, Sylvia Urban, Tien Huynh
Momordica cochinchinensis (Cucurbitaceae) is the richest source of lycopene and β-carotene of all known fruits but the influences of collection sites, variety and environment on carotenoid accumulation is unknown. This study analysed the carotenoid content of 44 M. cochinchinensis aril samples collected from Australia, Thailand and Vietnam using HPLC, UV-visible spectrophotometry and compared with the colorimetry method. The highest lycopene content was observed in samples collected from Ha Noi (7.76 mg/g) of Northern Vietnam and Lam Ha (6...
August 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28927597/active-and-smart-biodegradable-packaging-based-on-starch-and-natural-extracts
#8
Carolina Medina-Jaramillo, Oswaldo Ochoa-Yepes, Celina Bernal, Lucía Famá
Active and smart biodegradable films from cassava starch and glycerol with 5wt.% of different natural extracts such as green tea and basil were obtained by casting. Their functional capacity as antioxidants and their physicochemical properties achieved from the incorporation of these types of extracts were evaluated. The content of phenolic compounds in the extracts led to films with significant antioxidant activity, being greater in the case of the system containing green tea extract. Color changes in both materials after immersion in different media (acid and basic) due to the presence of chlorophyll and carotenoids in the extracts were observed, but the film with basil extract reacted most notably to the different pH...
November 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28926945/association-between-dietary-carotenoid-intake-and-bone-mineral-density-in-korean-adults-aged-30-75-years-using-data-from-the-fourth-and-fifth-korean-national-health-and-nutrition-examination-surveys-2008-2011
#9
Gebereamanuel Meron Regu, Hyesook Kim, You Jin Kim, Ju Eun Paek, Gunjeong Lee, Namsoo Chang, Oran Kwon
Age-related bone loss is a major public health problem. This cross-sectional study examined the association between the dietary intake of carotenoids and bone mineral density (BMD). Data from 8022 subjects (3763 males and 4259 females) aged 30-75 years included in the Korean National Health and Nutrition Examination Survey (2008-2011) were analyzed. BMD was measured by dual-energy X-ray absorptiometry. Intake of carotenoids was estimated using 24-h dietary recall. In multiple linear analysis, after adjusting for covariates, lutein + zeaxanthin and β-cryptoxanthin intake was positively associated with total hip BMD in males and premenopausal women respectively, while β-carotene intake was positively correlated with femoral neck, total hip, and whole-body BMD in postmenopausal women...
September 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28923881/dermal-carotenoid-measurement-is-inversely-related-to-anxiety-in-patients-with-breast-cancer
#10
David G Li, Gabrielle LeCompte, Lev Golod, Gary Cecchi, David Irwin, Alden Harken, Amy Matecki
Breast cancer is the most prevalent malignancy among women worldwide. Increased oxidative stress and poor subjective health outcomes have been associated with increased risk of cancer recurrence and metastasis, but few studies until now have explored the relationship between oxidative stress and chronic stress/anxiety. This study aims to examine the association between anxiety and a potential dermal correlate of oxidative stress in patients with breast cancer. 102 breast cancer patients were enrolled in a cross-sectional study at Highland Hospital, a county hospital in Oakland, California...
September 18, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28920835/erythrobacter-arachoides-sp-nov-isolated-from-ice-core
#11
Tingting Xing, Yongqin Liu, Ninglian Wang, Baiqing Xu, Keshao Liu, Liang Shen, Zhengquan Gu, Bixi Guo, Yuguang Zhou, Hongcan Liu
A Gram-stain-negative, rod-shaped bacterial strain, designed RC4-10-4T, belonging to the genus Erythrobacter, was isolated from the East Rongbuk Glacier on the Tibetan Plateau. Strain RC4-10-4T grew optimally at pH 7.0, at 25 °C and in the presence of 2 % (w/v) NaCl. Summed feature 3 (C16 : 1 ω6c and/or iso-C15 : 0 2-OH), summed feature 8 (C18 : 1 ω7c and/or C18 : 1 ω6c) and C16 : 0 were the major fatty acids. The major polar lipids were phosphatidylethanolamine, phosphatidylglycerol, diphosphatidylglycerol, sphingoglycolipid and phosphatidylcholine...
September 18, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28920431/isolation-and-characterization-of-a-novel-highly-selective-astaxanthin-producing-marine-bacterium
#12
Dalal Asker
A high throughput screening approach for astaxanthin-producing bacteria led to the discovery of a novel highly selective astaxanthin-producing marine bacterium (strain N-5). Phylogenetic analysis based on partial 16S rRNA gene and phenotypic metabolic testing indicated it belongs to the genus Brevundimonas. Therefore, it was designated as Brevundimonas sp. strain N-5. To identify and quantify carotenoids produced by strain N-5, HPLC-DAD and HPLC-MS methods were used. The culture conditions including media, shaking and time had significant effects on cell growth and carotenoids production including astaxanthin...
September 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28920391/-progress-in-metabolic-engineering-of-%C3%AE-carotene-synthesis
#13
Yanyan Wang, Jianmin Xing, Hongge Chen
β-carotene is an important natural plant pigment and has various physiological functions in organisms. With the proposition of systematic biology and progress in carotenoids biosynthesis since the 1960s, metabolic engineering has played a significant role in enhancing carotenoid production. In this review, we present β-carotene's traditional production methods and metabolic engineering strategies for constructing β-carotene-producing strains. Meanwhile, main problems and corresponding solutions to improve β-carotene yield of engineered strains were further analyzed, for further efficient microbial production of β-carotene...
April 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28920086/organic-compounds-generated-after-the-flow-of-water-through-micro-orifices-were-they-synthesized
#14
Tomiichi Hasegawa, Akiomi Ushida, Masaki Goda, Yasushi Ono
Micro-fluid mechanics is an important area of research in modern fluid mechanics because of its many potential industrial and biological applications. However, the field is not fully understood yet. In previous work, when passing ultrapure water (UPW) in which air was dissolved (UPW*) through micro-orifices, we found that the flow velocity decreased and stopped over time, and membranes were frequently formed in the orifice when the flow stopped. The membrane came from the dissolved air in UPW*, and membrane formation was closely related to electric charges generated in orifices by the flow...
August 2017: Heliyon
https://www.readbyqxmd.com/read/28918530/exogenous-and-endogenous-increase-in-fungal-ggpp-increased-fungal-taxol-production
#15
Sameh S M Soliman, Kareem A Mosa, Ali A El-Keblawy, Mohamed I Husseiny
Taxol is an anticancer identified in both endophytic fungus and its host plant. Plant Taxol is a diterpenoid with geranylgeranyl diphosphate (GGPP) mediates the biosynthesis of its terpenoid moiety. Previous report has suggested that fungal Taxol may require terpenoid pathway for its biosynthesis. Here in this study, feeding a Taxol-producing endophytic fungus (Paraconiothyrium SSM001) with terpenoid precursors including isopentenyl pyrophosphate (IPP, isoprene) and GGPP enhanced Taxol production threefold and fivefold, respectively, compared to the control...
September 16, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28915504/in-situ-optical-properties-of-foliar-flavonoids-implication-for-non-destructive-estimation-of-flavonoid-content
#16
Anatoly Gitelson, Olga Chivkunova, Tatiana Zhigalova, Alexei Solovchenko
Flavonoids are a ubiquitous multifunctional group of phenolics of paramount importance for the terrestrial plants involved in protection from biotic and abiotic stresses, color and chemical signaling and other functions. Deciphering of in situ absorption of foliar Flv is important but was thought to be impossible due to a strong overlap with other pigments, complex in situ chemistry of Flv and sophisticated leaf optics. We deduced in situ absorbance of foliar Flv and introduced a concept of specific absorbance spectrum indicative of each pigment group contribution to light absorption and provided a rationale for the choice of spectral bands for non-destructive assessment of Flv in leaves with variable content of other pigments including anthocyanins...
September 1, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28913689/the-evaluation-of-protective-effect-of-lycopene-against-genotoxic-influence-of-x-irradiation-in-human-blood-lymphocytes
#17
Aneta Gajowik, Małgorzata M Dobrzyńska
Many studies suggest that exogenous antioxidants may protect cells against DNA damage caused with ionizing radiation. One of the most powerful antioxidants is lycopene (LYC), a carotenoid derived from tomatoes. The aim of this study was to investigate, using the comet assay, whether LYC can act as protectors/modifiers and prevent DNA damage induced in human blood lymphocytes, as well as to mitigate the effects of radiation exposure. In this project, LYC, dissolved in DMSO at a concentration of 10, 20 or 40 μM/ml of cell suspension, was added to the isolated lymphocytes from human blood at appropriate intervals before or after the X-irradiation at doses of 0...
September 14, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/28913636/gelidibacter-flavus-sp-nov-isolated-from-activated-sludge-of-seawater-treatment-system
#18
Hyun-Sook Kim, John J Bang, Sang-Seob Lee
A Gram-stain-negative bacterial strain designated Con4(T) was isolated from activated sludge in a seawater treatment system. The strain was rod-shaped, motile, aerobic, and formed yellow-colored colonies on agar medium. Cells contained carotenoid pigments, but flexirubin-type pigments were absent. Based on 16S rRNA gene sequence analysis, the strain was assigned to the genus Gelidibacter. Optimum growth occurred at 20 °C, pH 7.0, and 1-2% (w/v) NaCl. Prominent fatty acid types were iso-C15:0, anteiso-C15:0, and iso-C16:0 3OH...
September 14, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28911809/taxonomy-ecology-and-biotechnological-applications-of-thraustochytrids-a-review
#19
REVIEW
Loris Fossier Marchan, Kim J Lee Chang, Peter D Nichols, Wilfrid J Mitchell, Jane L Polglase, Tony Gutierrez
Thraustochytrids were first discovered in 1934, and since the 1960's they have been increasingly studied for their beneficial and deleterious effects. This review aims to provide an enhanced understanding of these protists with a particular emphasis on their taxonomy, ecology and biotechnology applications. Over the years, thraustochytrid taxonomy has improved with the development of modern molecular techniques and new biochemical markers, resulting in the isolation and description of new strains. In the present work, the taxonomic history of thraustochytrids is reviewed, while providing an up-to-date classification of these organisms...
September 11, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28911653/assessment-of-rosehips-based-on-the-content-of-their-biologically-active-compounds
#20
Apurva Bhave, Vera Schulzova, Hana Chmelarova, Libor Mrnka, Jana Hajslova
In this study, an in-depth analysis of the unique set of rosehip samples from 71 Rosa genotypes was conducted with the aim to identify the most suitable ones for applications in the food and pharmaceutical industries based on the content of biologically active compounds. In the first part of our experiments, the antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl assay and the genotypes with the highest values were selected for the follow-up analysis. In the second part of experiments, the major classes of biologically active compounds in rosehips such as carotenoids, tocopherols, flavonoids, and triterpenoic acids were further quantified using liquid chromatography-based techniques...
July 2017: Journal of Food and Drug Analysis
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