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vitamin d deficiency in children

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https://www.readbyqxmd.com/read/29782992/single-ultra-high-dose-cholecalciferol-to-prevent-vitamin-d-deficiency-in-pediatric-hematopoietic-stem-cell-transplantation
#1
Gregory Wallace, Sonata Jodele, Kasiani C Myers, Christopher E Dandoy, Javier El-Bietar, Adam Nelson, Ashley Teusink-Cross, Pooja Khandelwal, Cynthia Taggart, Catherine M Gordon, Stella M Davies, Jonathan C Howell
BACKGROUND: Vitamin D (vitD) deficiency is prevalent among childhood hematopoietic stem cell transplantation (HSCT) recipients and associated with inferior transplant survival at 100 days after transplantation. Achieving and maintaining therapeutic vitD levels in HSCT recipients is extremely challenging in the first 3-6 months after transplant due to poor compliance in the setting of mucositis, and concomitant use of critical transplant drugs that interfere with vitD absorption. We sought to evaluate the safety and efficacy of a single, ultra-high dose of vitD given prior to childhood HSCT to maintain levels in a therapeutic range during the peri-transplantation period...
May 18, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29777304/no-improvement-in-vitamin-d-status-in-german-infants-and-adolescents-between-2009-and-2014-despite-public-recommendations-to-increase-vitamin-d-intake-in-2012
#2
Clemens Kunz, Jürgen Hower, Anette Knoll, Kristin L Ritzenthaler, Thomas Lamberti
PURPOSE: Vitamin D is a key component for the growth and development of children and adolescents, influencing a multitude of functions. Worldwide epidemiological studies have shown that minimum vitamin D blood levels of ≥ 20.0 ng/ml, often defined as vitamin D sufficiency by international and national nutrition and pediatric organizations, are often not met in practice. In 2012 the D-A-CH (Germany, Austria, Switzerland) nutrition societies increased their vitamin D intake recommendations fourfold from 200 IU (5 µg) to 800 IU (20 µg) per day...
May 18, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29773950/could-autism-be-associated-with-nutritional-status-in-the-palestinian-population-the-outcomes-of-the-palestinian-micronutrient-survey
#3
Mohammad Altamimi
Background: Autism spectrum disorder is a neurodevelopmental disorder. It is believed that the cause of autism is multifactorial, where genetic predispositions interact with environmental factors. In this context, micronutrients play a crucial role. Objective: To present evidence on current micronutrient status in Palestine and highlight its possible role in increasing problems of neurodevelopment disorders in general and autism in particular. Method: Analytical review of results...
2018: Nutrition and Metabolic Insights
https://www.readbyqxmd.com/read/29769814/combined-deficiencies-of-25-hydroxyvitamin-d-and-anemia-in-preschool-children-with-severe-early-childhood-caries-a-case-control-study
#4
Shannon Deane, Robert J Schroth, Atul Sharma, Celia Rodd
Background: Severe early childhood caries (S-ECC) is common and has adverse affects on children's health. Children with S-ECC have been shown to have anemia or vitamin D deficiency. No studies have assessed the presence of combined deficiencies with S-ECC. The purpose of our study was to examine whether those with S-ECC had a higher prevalence of combined anemia and low 25-hydroxyvitamin D (25(OH)D) compared to controls. Covariates associated with elevated parathyroid hormone (PTH), previously noted in S-ECC, were examined...
May 2018: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29764626/25-hydroxvitamin-d-concentrations-are-not-lower-in-children-with-bronchial-asthma-atopic-dermatitis-obesity-or-attention-deficient-hyperactivity-disorder-than-in-healthy-children
#5
Thomas Reinehr, Christian Langrock, Eckard Hamelmann, Thomas Lücke, Cordula Koerner-Rettberg, Martin Holtmann, Tanja Legenbauer, Stephanie Gest, Mirjam Frank, Börge Schmidt, Katharina Radkowski, Karl-Heinz Jöckel
Vitamin D (vitD) is involved in immune regulation, and its receptor has been identified in several tissues including lung, adipose tissue, brain, and skin. Based on these observations, it has been suggested that vitD has an essential role not only in bone metabolism but also in other diseases such as atopic dermatitis (AD), bronchial asthma (BA), attention-deficit/hyperactivity disorder (ADHD), and obesity because the affected tissues express vitD receptors. Furthermore, obesity, AD, and BA are regarded as inflammatory diseases...
April 2018: Nutrition Research
https://www.readbyqxmd.com/read/29761652/vitamin-d-status-and-associated-genetic-polymorphisms-in-a-cohort-of-uk-children-with-non-alcoholic-fatty-liver-disease
#6
P S Gibson, A Quaglia, A Dhawan, H Wu, S Lanham-New, K H Hart, E Fitzpatrick, J B Moore
BACKGROUND: Vitamin D deficiency has been associated with non-alcoholic fatty liver disease (NAFLD). However, the role of polymorphisms determining vitamin D status remains unknown. OBJECTIVES: The objectives of this study were to determine in UK children with biopsy-proven NAFLD (i) their vitamin D status throughout a 12-month period and (ii) interactions between key vitamin D-related genetic variants (nicotinamide adenine dinucleotide synthase-1/dehydrocholesterol reductase-7, vitamin D receptor, group-specific component, CYP2R1) and disease severity...
May 14, 2018: Pediatric Obesity
https://www.readbyqxmd.com/read/29751358/vitamin-d-was-not-associated-with-survival-or-cerebrospinal-fluid-cathelicidin-levels-in-children-with-bacterial-meningitis
#7
Okko Savonius, Tuula Pelkonen, Irmeli Roine, Heli Viljakainen, Sture Andersson, Josefina Fernandez, Heikki Peltola, Otto Helve
AIM: Vitamin D deficiency impairs the immunological system and has been associated with worse outcomes of infectious diseases, but its role in bacterial meningitis remains unknown. We investigated whether serum 25-hydroxyvitamin D concentrations related to disease outcomes and to cerebrospinal fluid cathelicidin concentrations in childhood bacterial meningitis. METHODS: All consecutively enrolled patients in a clinical trial on childhood bacterial meningitis in Latin America in 1996-2003 were considered and 142 children, with a median age of seven months who had a confirmed bacterial aetiology and frozen serum available for further analyses, were included in the present study...
May 11, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29739471/vitamin-d-in-pediatric-age-consensus-of-the-italian-pediatric-society-and-the-italian-society-of-preventive-and-social-pediatrics-jointly-with-the-italian-federation-of-pediatricians
#8
REVIEW
Giuseppe Saggese, Francesco Vierucci, Flavia Prodam, Fabio Cardinale, Irene Cetin, Elena Chiappini, Gian Luigi De' Angelis, Maddalena Massari, Emanuele Miraglia Del Giudice, Michele Miraglia Del Giudice, Diego Peroni, Luigi Terracciano, Rino Agostiniani, Domenico Careddu, Daniele Giovanni Ghiglioni, Gianni Bona, Giuseppe Di Mauro, Giovanni Corsello
Vitamin D plays a pivotal role in the regulation of calcium-phosphorus metabolism, particularly during pediatric age when nutritional rickets and impaired bone mass acquisition may occur.Besides its historical skeletal functions, in the last years it has been demonstrated that vitamin D directly or indirectly regulates up to 1250 genes, playing so-called extraskeletal actions. Indeed, recent data suggest a possible role of vitamin D in the pathogenesis of several pathological conditions, including infectious, allergic and autoimmune diseases...
May 8, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29734215/impact-of-a-vitamin-d-replacement-algorithm-in-children-and-young-adults-with-acute-lymphoblastic-leukemia
#9
Jennifer Young, Elizabeth Welin, Carina Braeutigam, Elizabeth Gilger, Adam Lane, Ralph Salloum
BACKGROUND: Pediatric cancer patients have a high prevalence of vitamin D deficiency. Children and young adults with acute lymphoblastic leukemia are at high risk for associated poor bone outcomes due to contributing effects of chemotherapy and supportive care. Evidence-based vitamin D guidelines are lacking in this population. MATERIALS AND METHODS: This is a retrospective study following the implementation of an institutional guideline for standardized monitoring and supplementing vitamin D based on 25-hydroxyvitamin D levels and patient age...
May 4, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29722846/high-dose-vitamin-d3-in-the-treatment-of-severe-acute-malnutrition-a-multicenter-double-blind-randomized-controlled-trial
#10
Javeria Saleem, Rubeena Zakar, Muhammad Z Zakar, Mulugeta Belay, Marion Rowe, Peter M Timms, Robert Scragg, Adrian R Martineau
Background: Vitamin D deficiency is common in children with severe acute malnutrition, in whom it is associated with severe wasting. Ready-to-use therapeutic food (the standard treatment) contains modest amounts of vitamin D that do not reliably correct deficiency. Objective: The aim of this study was to determine whether high-dose oral vitamin D3 enhances weight gain and development in children with uncomplicated severe acute malnutrition. Design: We conducted a randomized placebo-controlled trial of high-dose vitamin D3 supplementation in children aged 6-58 mo with uncomplicated severe acute malnutrition in Pakistan...
May 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29710038/current-vitamin-d-status-in-healthy-japanese-infants-and-young-children
#11
Satoshi Nakano, Mitsuyoshi Suzuki, Kei Minowa, Saeko Hirai, Noriyuki Takubo, Yuko Sakamoto, Muneaki Ishijima, Eri Hoshino, Akifumi Tokita, Toshiaki Shimizu
This study aimed to characterize serum 25-hydroxyvitamin D (25OH-D) values among Japanese children aged ≤48 mo. The study included 290 healthy infants and young children aged 0-48 mo (males/females=166/124) living in Shizuoka or Tokyo. The subjects were divided into three groups by age (Low Age: 0-5, Middle Age: 6-15, High Age: 16-48 mo). The vitamin D deficient state was defined as 25OH-D <12 ng/mL, the insufficient state as 12-20 ng/mL, and the sufficient state as >20 ng/mL. The seasonal variation of serum 25OH-D levels was also analyzed...
2018: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29709052/can-vitamin-d-help-in-achieving-asthma-control-vitamin-d-revisited-an-updated-insight
#12
Izabela Szymczak, Rafal Pawliczak
Asthma - a prolonged respiratory disease related with hyper-responsiveness and increased inflammation of airways; affects millions peoples worldwide. Vitamin D possess anti-inflammatory and immunomodulatory activities. Its deficiency (the level less than 20 ng/mL in the serum) is found to be related to occurrence of pulmonary diseases including bacterial and viral infections and asthma. Some studies indicate that low levels of vitamin D in the serum are related to reduced lung function and increased airway inflammation as well as overall poor results in asthmatic patients...
2018: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/29699378/use-of-vitamin-d-in-children-and-adults-frequently-asked-questions
#13
Gül Yeşiltepe Mutlu, Şükrü Hatun
In recent years, the increase in interest and use of vitamin D has been attributed mainly to the effects of vitamin D on the extra-skeletal effects and confusion about normal reference values for serum 25OHD. However, The Institute of Medicine (IOM), which determines daily intake of nutrients, vitamins and minerals in the United States, emphasizes that there is no additional benefit of having a 25OHD level above 20 ng/ml in terms of PTH suppression, calcium absorption and "fall risk". Taking into consideration that there has not been a significant increase in vitamin D deficiency and related conditions in Turkey over the past 5 years, it is not hard to suppose that this increase is due to declarations of doctors who have shown vitamin D as a "panacea’’ in media platforms...
April 27, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29696043/prevalence-of-vitamin-d-deficiency-and-associated-risk-factors-in-cerebral-palsy-a-study-in-north-west-of-iran
#14
Vahideh Toopchizadeh, Mohammad Barzegar, Shahab Masoumi, Fatemeh Jahanjoo
Objective: This study aimed to compare the prevalence of 25-hydroxyvitamin D deficiency in cerebral palsied (CP) with healthy control children and evaluate possible correlations between 25-hydroxyvitamin D and severity of CP and motor function. Materials & Methods: In this case-control study, serum levels of 25-hydroxyvitamin D were evaluated in 65 children with CP and compared with 65 healthy children referred to Tabriz Pediatric Hospital, Tabriz, northwestern Iran in 2015...
2018: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29696042/bone-metabolism-disorder-in-epileptic-children
#15
MAaryam Nakhaee Moghadam, Alireza Teimouri, Ali Khajeh, Seyed Bahare Hoseini
Objective: There are frequent anti-epileptic drugs used in management of epilepsy. Anti-epileptic drugs may have some complications on bone and vitamin D metabolism. This study aimed to comparison the bone metabolism disorder in epileptic children with healthy child in Zahedan, eastern Iran from Jul 2014 to Jun 2015. Materials & Methods: This case-control study was performed on bone metabolism disorder in epileptic children between 2014-2015. Forty epileptic children were enrolled based on accessibility scheme and 40 participants randomly selected for control group from those referred to the pediatric ward and clinic of Ali Ebn Abi Talib Hospital and Ali Asghar Clinic in Zahedan City, Sistan & Baluchestan Province, eastern Iran...
2018: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29693403/second-national-integrated-micronutrient-survey-in-iran-study-design-and-preliminary-findings
#16
Hamed Pouraram, Abolghasem Djazayery, Kazem Mohammad, Mahboobeh Parsaeian, Zahra Abdollahi, Ahmadreza Dorosty Motlagh, Mahmoud Djalali, Katayoon Khodaverdian, Gity Sotoudeh, Amirhusein Yarparvar, Ramin Heshmat, Fereydoun Siassi
BACKGROUND: The main objective of the Second National Integrated Micronutrient Survey (NIMS-II) was to assess the nutritional status of four micronutrients, namely iron, zinc, and vitamins A and D, and also to conduct an anthropometric assessment of selected groups of children, adolescents, pregnant women, and adults, disaggregated by sex and residential area in nationally representative samples. This paper reports the design of the study along with preliminary findings. METHODS: In this study, 32 770 individuals were selected by using single-stage cluster sampling...
April 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29684480/fetuin-b-links-vitamin-d-deficiency-and-pediatric-obesity-direct-negative-regulation-by-vitamin-d
#17
Gillian E Walker, Antonia Follenzi, Valentina Bruscaggin, Marcello Manfredi, Simonetta Bellone, Emilio Marengo, Luigi Maiuri, Flavia Prodam, Gianni Bona
Vitamin D (VD) deficiency (VDD) correlates to obesity, with VD a recognized mediator of metabolic diseases. From a previous proteomic study identifying adiponectin as a link between VDD and pediatric obesity, herein we analysed another protein (SSP2301) increased with VDD. A focused 2D-electrophoretic analysis identified 4 corresponding plasma proteins, with one predicted to be fetuin B (FETUB). FETUB was studied due to its emerging role in metabolic diseases and cytogenetic location (3q27.3) with adiponectin...
April 20, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29684478/vitamin-d-deficiency-promotes-prostatic-hyperplasia-in-middle-age-mice-through-exacerbating-local-inflammation
#18
Zhi-Hui Zhang, Biao Luo, Shen Xu, Lin Fu, Yuan-Hua Chen, Cheng Zhang, Hua Wang, Dong-Dong Xie, De-Xiang Xu
Vitamin D deficiency is especially prevalent in pregnant women and children. Our recent study demonstrated that vitamin D deficiency in early life disturbed testicular development. This study investigated the effects of vitamin D deficiency in early life on prostatic hyperplasia in middle-aged mice. In control group, dams and their male pups were fed with standard-chow diets. In VDD group, dams were fed with vitamin D deficient (VDD) diets throughout pregnancy and lactation. After weaning, male pups continued to be fed with VDD diets...
April 20, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29680189/vitamin-d-non-sufficiency-is-prevalent-in-children-with-chronic-liver-disease-in-a-tropical-country
#19
Way Seah Lee, Muhammad Yazid Jalaludin, Shin Yee Wong, Sik Yong Ong, Hee Wei Foo, Ruey Terng Ng
BACKGROUND: To determine vitamin D status in children with chronic liver disease (CLD) in a tropical country. METHODS: Cross-sectional study in Malaysian children with CLD. Factors affecting serum vitamin D level (definition: deficient < 30 nmol/L; insufficient 30-50 nmol/L; sufficient ≥ 50 nmol/L) was analyzed. RESULTS: Of the 59 children studied (males 32, 54%; median age 6.8 ± 5.3 years), the three most common causes were biliary atresia (n = 25), autoimmune hepatitis (n = 16) and sclerosing cholangitis (n = 6)...
April 5, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29668535/response-to-long-term-vitamin-d-therapy-for-bone-disease-in-children-with-sickle-cell-disease
#20
Kristen M Williams, Margaret T Lee, Maureen Licursi, Gary M Brittenham, Ilene Fennoy
Patients with sickle cell disease (SCD) are at risk for bone fragility from multiple factors including vitamin D deficiency. To date, no studies have evaluated the efficacy and safety of long-term vitamin D therapy for bone disease in children with SCD. We report a cohort of 4 children with SCD found to have severe vitamin D deficiency, secondary hyperparathyroidism, and abnormal bone mineral density treated with monthly high-dose oral cholecalciferol over 2 years. All patients exhibited a positive response to therapy without hypervitaminosis D or hypercalcemia...
April 17, 2018: Journal of Pediatric Hematology/oncology
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