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vitamin d deficiency in children

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https://www.readbyqxmd.com/read/28550622/genomic-instability-related-to-zinc-deficiency-and-excess-in-an-in-vitro-model-is-the-upper-estimate-of-the-physiological-requirements-recommended-for-children-safe
#1
Gisel Padula, María Virginia Ponzinibbio, Rocío Celeste Gambaro, Analía Isabel Seoane
Micronutrients are important for the prevention of degenerative diseases due to their role in maintaining genomic stability. Therefore, there is international concern about the need to redefine the optimal mineral and vitamin requirements to prevent DNA damage. We analyzed the cytostatic, cytotoxic, and genotoxic effect of in vitro zinc supplementation to determine the effects of zinc deficiency and excess and whether the upper estimate of the physiological requirement recommended for children is safe. To achieve zinc deficiency, DMEM/Ham's F12 medium (HF12) was chelated (HF12Q)...
May 26, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28542114/predictors-of-pouchitis-after-ileal-pouch-anal-anastomosis-in-pediatric-onset-ulcerative-colitis
#2
Firas Rinawi, Amit Assa, Rami Eliakim, Yael Mozer Glassberg, Vered Nachmias Friedler, Yaron Niv, Yoram Rosenbach, Ari Silbermintz, Noam Zevit, Raanan Shamir
OBJECTIVES: Few studies have reported on the incidence and risk factors for pouchitis following colectomy and ileal pouch-anal anastomosis (IPAA) in patients with pediatric-onset ulcerative colitis (UC). We aimed to determine clinical predictors for the development of pouchitis following IPAA in this population. PATIENTS AND METHODS: We performed a retrospective chart review of all pediatric UC cases that were diagnosed at the Schneider Children's Medical Center of Israel between 1981 and 2013 and who underwent colectomy during disease course...
May 24, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28534725/vitamin-d-deficiency-and-sufficiency-among-canadian-children-residing-at-high-latitude-following-the-revision-of-the-rda-of-vitamin-d-intake-in-2010-corrigendum
#3
Lalani L Munasinghe, Yan Yuan, Noreen D Willows, Erin L Faught, John P Ekwaru, Paul J Veugelers
No abstract text is available yet for this article.
April 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28532484/seasonal-variations-of-vitamin-d-and-its-relation-to-lipid-profile-in-iranian-children-and-adults
#4
Sakineh Nouri Saeidlou, Davoud Vahabzadeh, Fariba Babaei, Zakaria Vahabzadeh
BACKGROUND: Vitamin D has a multitude of functional properties and acts like a hormone in the body. Its effect on the lipid profile is one of the proposed mechanisms for its relationship with many disorders during its deficiency. But, this relationship is still conflicting and debatable, so this study was conducted to determine the association between serum level of vitamin D and lipid profiles, including serum concentrations of cholesterol, triglyceride (TG), HDL, and LDL in healthy subjects...
May 22, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/28531780/vitamin-d-status-and-the-effects-of-oral-vitamin-d-treatment-in-children-with-vitiligo-a-prospective-study
#5
Gülay Karagüzel, Nil P Sakarya, Sevgi Bahadır, Selçuk Yaman, Ayşenur Ökten
BACKGROUND & AIMS: Vitiligo is a pigmentary disorder and autoimmune pathogenesis seems most likely. Decreased vitamin D levels have been related to several autoimmune diseases. Little is known about the association of vitiligo and vitamin D. We aimed to evaluate serum 25-hydroxyvitamin D [25(OH)D] levels in children with vitiligo and to determine the efficacy of oral vitamin D therapy on the repigmentation of vitamin D deficient patients. METHODS: Thirty patients aged 6-17 years with vitiligo and 30 sex- and age-matched apparently healthy controls were included in this prospective study...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28513555/effect-of-low-dose-vitamin-d-supplementation-on-serum-25-oh-d-in-school-children-and-white-collar-workers
#6
Ronghua Zhang, Xiamusiye Muyiduli, Danting Su, Biao Zhou, Yueqiang Fang, Shuying Jiang, Shuojia Wang, Lichun Huang, Minjia Mo, Minchao Li, Bule Shao, Yunxian Yu
OBJECTIVE: Our study aimed to investigate the nutritional vitamin D status of school children aged 9-15 years and white-collar workers in Zhejiang province, and evaluate the efficacy of low-dose-oral vitamin D supplementation in both populations. METHODS: We conducted a prospective controlled trial during March 2014 to November 2015, comparing the efficacy of vitamin D supplements (400 IU/day) with non-intervention for 18 months in school children aged 9-15 years...
May 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28508087/the-vitamin-d-for-enhancing-the-immune-system-in-cystic-fibrosis-disc-trial-rationale-and-design-of-a-multi-center-double-blind-placebo-controlled-trial-of-high-dose-bolus-administration-of-vitamin-d3-during-acute-pulmonary-exacerbation-of-cystic-fibrosis
#7
Vin Tangpricha, Ellen M Smith, Jose Binongo, Suzanne E Judd, Thomas R Ziegler, Seth Walker, Rabindra Tirouvanziam, Susu M Zughaier, Moon Jeong Lee, Supavit Chesdachai, Wendy A Hermes, James F Chmiel, Amit Gaggar, Ruth E Grossmann, Patricia M Joseph, Jessica A Alvarez
Vitamin D deficiency is highly prevalent in children and adults with cystic fibrosis (CF). Recent studies have found an association between vitamin D status and risk of pulmonary exacerbations in children and adults with CF. The ongoing Vitamin D for enhancing the Immune System in Cystic fibrosis (DISC) study is a multi-center, double-blind, randomized, placebo-controlled trial that will test the hypothesis of whether high dose vitamin D given as a single oral bolus of 250,000 IU to adults with CF during a pulmonary exacerbation followed by a maintenance dose of vitamin D will improve time to next pulmonary exacerbation and re-hospitalization, improve survival and lung function compared to placebo and reduce the rates of pulmonary exacerbation,...
June 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/28504486/high-prevalence-of-vitamin-d-deficiency-among-children-with-chronic-kidney-disease-and-kidney-transplant
#8
Paula Coccia, Juliana Blazquez, Maritza Contreras, Verónica Ferrais, Claudia Raddavero, Lidia Ghezzi, Julio Busaniche, Gonzalo Beneitez, Andrea Kozak, Jorge Ferraris
INTRODUCTION: Vitamin D (25(OH)D) deficiency is common among patients with chronic kidney disease (CKD). Our objective was to establish the prevalence of 25(OH)D deficiency among children with CKD and identify risk factors. A correlation was observed between 25(OH)D and parathormone intact molecule. POPULATION AND METHODS: Cross-sectional study conducted between January 2013 and December 2015. Patients younger than 19 years old with and without CKD were included...
June 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28481882/vitamin-d-supplementation-and-growth-in-urban-mongol-school-children-results-from-two-randomized-clinical-trials
#9
Davaasambuu Ganmaa, Jennifer J Stuart, Nyamjav Sumberzul, Boldbaatar Ninjin, Edward Giovannucci, Ken Kleinman, Michael F Holick, Walter C Willett, Lindsay A Frazier, Janet W Rich-Edwards
BACKGROUND: Symptomatic vitamin D deficiency is associated with slowed growth in children. It is unknown whether vitamin D repletion in children with asymptomatic serum vitamin D deficiency can restore normal growth. OBJECTIVE: We tested the impact of vitamin D-supplementation on serum concentrations of 25-hydroxyvitamin D [25(OH)D] and short-term growth in Mongol children, with very low serum vitamin D levels in winter. DESIGN: We conducted two randomized, double-blind, placebo-controlled trials in urban school age children without clinical signs of rickets...
2017: PloS One
https://www.readbyqxmd.com/read/28472874/associations-of-seasonal-patterns-and-vitamin-d-levels-with-onset-and-flares-of-pediatric-inflammatory-bowel-disease
#10
Yael Brandvayman, Firas Rinawi, Raanan Shamir, Amit Assa
BACKGROUND: As inflammatory bowel disease (IBD) might be associated with environmental factors such as seasonal patterns and low vitamin D levels we aimed to assess their association with IBD onset and flares in a large cohort of children. METHODS: The records of 623 pediatric onset IBD patients were reviewed retrospectively including age at onset, gender, severity indices, month of first symptom, and vitamin D levels at diagnosis. For a subgroup of patients, data included date of first flare and vitamin D levels during flare and remission...
May 4, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28470840/vitamin-d-deficiency-causes-rickets-in-an-urban-informal-settlement-in-kenya-and-is-associated-with-malnutrition
#11
Kelsey D J Jones, C Ulrich Hachmeister, Maureen Khasira, Lorna Cox, Inez Schoenmakers, Caroline Munyi, H Samira Nassir, Barbara Hünten-Kirsch, Ann Prentice, James A Berkley
The commonest cause of rickets worldwide is vitamin D deficiency, but studies from sub-Saharan Africa describe an endemic vitamin D-independent form that responds to dietary calcium enrichment. The extent to which calcium-deficiency rickets is the dominant form across sub-Saharan Africa and in other low-latitude areas is unknown. We aimed to characterise the clinical and biochemical features of young children with rickets in a densely populated urban informal settlement in Kenya. Because malnutrition may mask the clinical features of rickets, we also looked for biochemical indices of risk in children with varying degrees of acute malnutrition...
May 3, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28467404/utility-of-sun-reactive-skin-typing-and-melanin-index-for-discerning-vitamin-d-deficiency
#12
Arshad T Khalid, Charity G Moore, Christopher Hall, Flora Olabopo, Nigel L Rozario, Michael F Holick, Susan L Greenspan, Kumaravel Rajakumar
BACKGROUND: Skin color, a vitamin D status determinant, can be assessed subjectively by Fitzpatrick sun-reactive skin typing (FST) and objectively by melanin index (MI). FST was validated against MI for discerning vitamin D deficiency [serum 25-hydroxyvitamin D (25(OH)D) <20 ng/ml] in children. METHODS: We measured FST, MI, and serum 25(OH)D in healthy, 8- to 18-year-old children from one of two vitamin D trials. MI from forehead, hand, and upper arm split at the median of the more racially-balanced study cohort and FST (I-III vs...
May 3, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28453069/-double-burden-malnutrition-during-growth-is-becoming-a-reality-in-colombia
#13
Gustavo Cediel-Giraldo, Erika Castaño-Moreno, Diego Gaitán-Charry
Several reports have described in the last decade the coexistence of accelerated increase of obesity with micronutrient deficiencies in developed countries, and is becoming evident in developing nations. This condition may be especially deleterious in children and adolescents with consequences in metabolic risk and growth since early in life. This review describes the evidence of double burden malnutrition during growth period focused on six nutrients (iron, zinc, calcium, vitamin D, vitamin A, sodium, folic acid and vitamin B12) and its biological mechanisms associated with non-communicable disease through span life...
August 2016: Revista de Salud Pública
https://www.readbyqxmd.com/read/28452835/vitamin-d-status-cardiometabolic-liver-and-mental-health-status-in-obese-youth-attending-a-pediatric-weight-management-centre
#14
Krista MacDonald, Kristine Godziuk, Jason Yap, Rena LaFrance, Mohammad Ansarian, Andrea Haqq, Diana R Mager
BACKGROUND: Vitamin D (VitD) deficiency and obesity are reaching epidemic proportions in North America, particularly in those with co-morbid conditions such as diabetes or liver disease. The study objective was to determine the prevalence of suboptimal vitD status and interrelationships with anthropometric, cardio-metabolic, liver, mental health and lifestyle (sleep/screen time) parameters in an ambulatory population of obese children. METHODS: Children (2-18 years) old attending a pediatric weight management clinic (n = 217) were retrospectively reviewed...
April 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28449868/vitamin-d-and-bronchial-asthma-an-overview-of-data-from-the-past-5-years
#15
REVIEW
Sannette C Hall, Devendra K Agrawal
PURPOSE: Vitamin D is a potent immunomodulator capable of dampening inflammatory signals in several cell types involved in the asthmatic response. Its deficiency has been associated with increased inflammation, exacerbations, and overall poor outcomes in patients with asthma. Given the increase in the prevalence of asthma over the past few decades, there has been enormous interest in the use of vitamin D supplementation as a potential therapeutic option. Here, we critically reviewed the most recent findings from in vitro studies, animal models, and clinical trials regarding the role of vitamin D in treating bronchial asthma...
April 24, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28446959/gestational-vitamin-d-deficiency-and-autism-spectrum-disorder
#16
Anna A E Vinkhuyzen, Darryl W Eyles, Thomas H J Burne, Laura M E Blanken, Claudia J Kruithof, Frank Verhulst, Tonya White, Vincent W Jaddoe, Henning Tiemeier, John J McGrath
BACKGROUND: There is growing interest in linking vitamin D deficiency with autism spectrum disorders (ASDs). The association between vitamin D deficiency during gestation, a critical period in neurodevelopment, and ASD is not well understood. AIMS: To determine the association between gestational vitamin D status and ASD. METHOD: Based on a birth cohort (n=4334), we examined the association between 25-hydroxyvitamin D (25OHD), assessed from both maternal mid-gestation sera and neonatal sera, and ASD (defined by clinical records; n=68 cases)...
March 2017: BJPsych Open
https://www.readbyqxmd.com/read/28442927/mechanical-factors-and-vitamin-d-deficiency-in-schoolchildren-with-low-back-pain-biochemical-and-cross-sectional-survey-analysis
#17
Ahmad H Alghadir, Sami A Gabr, Einas S Al-Eisa
OBJECTIVE: This study was designed to evaluate the role of vitamin D, muscle fatigue biomarkers, and mechanical factors in the progression of low back pain (LBP) in schoolchildren. BACKGROUND: Children and adolescents frequently suffer from LBP with no clear clinical causes, and >71% of schoolchildren aged 12-17 years will show at least one episode of LBP. MATERIALS AND METHODS: A total of 250 schoolchildren aged 12-16 years were randomly enrolled in this study...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28441982/25-hydroxyvitamin-d-biomarkers-of-eosinophilic-inflammation-and-airway-remodeling-in-children-with-newly-diagnosed-untreated-asthma
#18
Grazyna Sypniewska, Magdalena Krintus, Gabriele Fulgheri, Joanna Siodmiak, Magdalena Kuligowska-Prusinska, Beata Stepien-Jaszowska, Radosława Staszak-Kowalska, Anna Zawadzka-Krajewska, Szymon Kierat, Katarzyna Bergmann, Urszula Demkow
BACKGROUND: Low 25-hydroxyvitamin D (25[OH]D) and asthma development may be related to airway remodeling and eosinophilia. Periostin is proposed as a key molecule that links remodeling and eosinophilic inflammation. OBJECTIVE: We evaluated the association of 25(OH)D concentration with periostin, peripheral blood eosinophil counts, and immunoglobulin E (IgE) in children with newly diagnosed asthma. METHODS: The study included 150 children: 110 with atopic asthma and 40 constituted a reference group...
May 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28441981/vitamin-d-and-food-allergies-in-children-a-systematic-review-and-meta-analysis
#19
Erin K Willits, Zhen Wang, Jay Jin, Bhavisha Patel, Megan Motosue, Amrita Bhagia, Jehad Almasri, Patricia J Erwin, Seema Kumar, Avni Y Joshi
BACKGROUND: Vitamin D insufficiency has been associated with immune dysfunction and linked to the epidemic of atopic diseases in the Western hemisphere, yet there are studies with conflicting results, and the risk has not been quantified uniformly across studies. OBJECTIVE: To perform a systematic review and meta-analysis to evaluate and quantify if vitamin D deficiency is associated with the presence and persistence of food allergy. METHODS: A systematic review was undertaken to assess for the association between food allergy and vitamin D status in children...
May 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28440755/dysfunctional-immunometabolic-effects-of-vitamin-d-deficiency-increased-cardiometabolic-risk-potential-epidemiological-alert-in-america
#20
Martin Rosas-Peralta, Michael F Holick, Gabriela Borrayo-Sánchez, Alejandra Madrid-Miller, Erick Ramírez-Árias, Efrain Arizmendi-Uribe
Vitamin D deficiency is a serious public health problem worldwide that affects not only skeletal health, but also a wide range of acute and chronic diseases. However, there is still skepticism because of the lack of randomized, controlled trials to support association studies on the benefits of vitamin D for non-skeletal health. This review was based on articles published during the 1980-2015 obtained from the Cochrane Central Register of controlled trials, MEDLINE and PubMed, and focuses on recent challenges with regard to the definition of vitamin D deficiency and how to achieve optimal serum 25-hydroxyvitamin D levels from dietary sources, supplements, and sun exposure...
March 2017: Endocrinol Diabetes Nutr
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