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Steroid induced osteoporosis

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https://www.readbyqxmd.com/read/27908909/dtb-select-12-december-2016
#1
(no author information available yet)
Azithromycin of no benefit for asthma attacks ● Risk of heart failure with NSAIDs ● Bisphosphonates and steroid-induced osteoporosis ● Triple therapy for moderate-to-severe COPD: marginal benefits ● Much data on adverse events remains unpublished ● Rising placebo response rates in antidepressant trials a 'myth' ● Prenatal fetal RhD testing recommended.
December 1, 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27846298/damage-in-the-multiethnic-malaysian-systemic-lupus-erythematosus-sle-cohort-comparison-with-other-cohorts-worldwide
#2
Syahrul Sazliyana Shaharir, Heselynn Hussein, Sakthiswary Rajalingham, Mohd Shahrir Mohamed Said, Abdul Halim Abdul Gafor, Rozita Mohd, Ruslinda Mustafar
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease and despite the improvement in the survival in the past few decades, the morbidity due to disease damage remains significant. The objectives of this study were to investigate the disease damagepattern and determine the associated factors of damage in the multi-ethnic Malaysian SLE patients. We consecutively 424SLE patients who attended a consistent follow-up at the National University of Malaysia Medical Centre and Putrajaya Hospital were recruited...
2016: PloS One
https://www.readbyqxmd.com/read/27706804/bisphosphonates-for-steroid-induced-osteoporosis
#3
REVIEW
Claire S Allen, James Hs Yeung, Ben Vandermeer, Joanne Homik
BACKGROUND: This is an update of a Cochrane Review first published in 1999. Corticosteroids are widely used in inflammatory conditions as an immunosuppressive agent. Bone loss is a serious side effect of this therapy. Several studies have examined the use of bisphosphonates in the prevention and treatment of glucocorticosteroid-induced osteoporosis (GIOP) and have reported varying magnitudes of effect. OBJECTIVES: To assess the benefits and harms of bisphosphonates for the prevention and treatment of GIOP in adults...
October 5, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27692101/application-of-calcium-phosphates-and-fibronectin-as-complementary-treatment-for-osteoporotic-bone-fractures
#4
Javier Quintana Plaza, Lorena Benito Garzón, Beatriz Bravo Gimenez, Belén Fernández-Montes Moraleda, Francisco Collía, Luis M Rodríguez-Lorenzo
INTRODUCTION: The gradual aging of the population results in increased incidence of osteoporotic bone fractures. In a good quality bone, the fixation with the usual methods is adequate, but not in osteoporotic bone, in which consolidation delays and other complications are common, with failure rates for screws up to 25%. OBJECTIVE: To test fibronectin loaded hydroxyapatite as a complementary treatment for osteoporotic fractures. MATERIAL AND METHODS: This study was performed in a vivo model; 42 female osteoporotic adult rabbits 4-5kg (White New Zealand) were used...
September 2016: Injury
https://www.readbyqxmd.com/read/27666694/-steroids-induced-osteoporosis-due-to-the-treatment-for-pulmonary-diseases
#5
Nobuyuki Horita, Takeshi Kaneko
Corticosteroids are key medications to treat pulmonary diseases. A variety of medications, doses, administration route, and duration of corticosteroids were chosen for each of pulmonary diseases. Although corticosteroids are potent medications, they often cause serious adverse effects such as osteoporosis, diabetes, and immunosuppression. Thus, physicians have to properly assess the risk of adverse effects to prevent them. In this review, we discuss the risk of osteoporosis by corticosteroids that are prescribed for pulmonary diseases...
2016: Clinical Calcium
https://www.readbyqxmd.com/read/27622887/androgens-have-antiresorptive-effects-on-trabecular-disuse-osteopenia-independent-from-muscle-atrophy
#6
Michaël R Laurent, Ferran Jardí, Vanessa Dubois, Dieter Schollaert, Rougin Khalil, Evelien Gielen, Geert Carmeliet, Frank Claessens, Dirk Vanderschueren
Aging hypogonadal men are at increased risk of osteoporosis and sarcopenia. Testosterone is a potentially appealing strategy to prevent simultaneous bone and muscle loss. The androgen receptor (AR) mediates antiresorptive effects on trabecular bone via osteoblast-lineage cells, as well as muscle-anabolic actions. Sex steroids also modify the skeletal response to mechanical loading. However, it is unclear whether the effects of androgens on bone remain effective independent of mechanical stimulation or rather require indirect androgen effects via muscle...
September 10, 2016: Bone
https://www.readbyqxmd.com/read/27298501/an-experimental-study-to-evaluate-the-antiosteoporotic-effect-of-panchatikta-ghrita-in-a-steroid-induced-osteoporosis-rat-model
#7
Renuka Munshi, Tanvi Patil, Chetan Garuda, Dushyant Kothari
OBJECTIVE: The study was conducted to develop the glucocorticoid-induced osteoporosis (GIO) model in Sprague-Dawley weanling rats using different doses of methylprednisolone (MP) and evaluate the antiosteoporotic effect of a classical ayurvedic formulation, Panchatikta Ghrita (PG), in this model. MATERIALS AND METHODS: Institutional Animal Ethics Committee approval was obtained. Development of model was done by subcutaneous injection of 2 doses of MP (14 and 28 mg/kg/week) for 4 weeks in 21-day old weanlings...
May 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27113550/vertebral-implantation-of-nell-1-enhances-bone-formation-in-an-osteoporotic-sheep-model
#8
Aaron W James, Michael Chiang, Greg Asatrian, Jia Shen, Raghav Goyal, Choon G Chung, Le Chang, Swati Shrestha, A Simon Turner, Howard B Seim, Xinli Zhang, Benjamin M Wu, Kang Ting, Chia Soo
BACKGROUND: Vertebral compression fractures related to osteoporosis greatly afflict the aging population. One of the most commonly used therapy today is balloon kyphoplasty. However, this treatment is far from ideal and is associated with significant side effects. NELL-1, an osteoinductive factor that possesses both pro-osteogenic and anti-osteoclastic properties, is a promising candidate for an alternative to current treatment modalities. This study utilizes the pro-osteogenic properties of recombinant human NELL-1 (rhNELL-1) in lumbar spine vertebral defect model in osteoporotic sheep...
June 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27111233/from-the-gut-to-the-strut-where-inflammation-reigns-bone-abstains
#9
Jameel Iqbal, Tony Yuen, Li Sun, Mone Zaidi
In this issue of the JCI, Li et al. show that germ-free mice, when chemically castrated, do not lose bone - a finding that unequivocally establishes a role of gut microbiota in mediating hypogonadal bone loss. Additionally and not unexpectedly, probiotics reversed hypogonadal osteopenia in sex steroid-deficient mice by preventing the disruption of gut barrier function and dampening cytokine-induced inflammation. The authors propose that TNFα is a key mediator; however, it is very likely that other molecules - including IL-1, IL-6, IL-17, RANKL, OPG, and CCL2 - modulate probiotic action...
June 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27111232/sex-steroid-deficiency-associated-bone-loss-is-microbiota-dependent-and-prevented-by-probiotics
#10
Jau-Yi Li, Benoit Chassaing, Abdul Malik Tyagi, Chiara Vaccaro, Tao Luo, Jonathan Adams, Trevor M Darby, M Neale Weitzmann, Jennifer G Mulle, Andrew T Gewirtz, Rheinallt M Jones, Roberto Pacifici
A eubiotic microbiota influences many physiological processes in the metazoan host, including development and intestinal homeostasis. Here, we have shown that the intestinal microbiota modulates inflammatory responses caused by sex steroid deficiency, leading to trabecular bone loss. In murine models, sex steroid deficiency increased gut permeability, expanded Th17 cells, and upregulated the osteoclastogenic cytokines TNFα (TNF), RANKL, and IL-17 in the small intestine and the BM. In germ-free (GF) mice, sex steroid deficiency failed to increase osteoclastogenic cytokine production, stimulate bone resorption, and cause trabecular bone loss, demonstrating that the gut microbiota is central in sex steroid deficiency-induced trabecular bone loss...
June 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27096794/experimental-osteoporosis-in-sheep-mechanical-and-histological-approach
#11
Z Kiełbowicz, A Piątek, P Kuropka, E Mytnik, A Nikodem, J Bieżyński, P Skrzypczak, C Pezowicz, J Kuryszko, P Reichert
The implementation of new methods of osteoporotic therapy requires tests on animal model. The use of sheep as model has numerous advantages over other animals. The aim of this study was to describe the change in parameters in sheep with osteoporosis induced using steroids and ovariorectomy methods as opposed to the parameters in healthy sheep. The study was performed on female "merinos" breed sheep divided into the three groups: negative control (NC)--healthy animals, positive control (PC)--ovariorectomized animals and steroid control group (SC)--in which methylprednisolone was administered...
2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/26981520/multiple-fractures-in-patient-with-graves-disease-accompanied-by-isolated-hypogonadotropic-hypogonadism
#12
Hyon-Seung Yi, Ji Min Kim, Sang Hyeon Ju, Younghak Lee, Hyun Jin Kim, Koon Soon Kim
Isolated hypogonadotropic hypogonadism (IHH) is known to decrease bone mineral density due to deficiency of sex steroid hormone. Graves' disease is also an important cause of secondary osteoporosis. However, IHH does not preclude the development of primary hyperthyroidism caused by Graves' disease, leading to more severe osteoporosis rapidly. Here, we describe the first case of 35-year-old Asian female patient with IHH accompanied by Graves' disease and osteoporosis-induced multiple fractures. Endocrine laboratory findings revealed preserved anterior pituitary functions except for secretion of gonadotropins and showed primary hyperthyroidism with positive autoantibodies...
February 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/26935513/osteoporosis-in-gastrointestinal-diseases
#13
REVIEW
Iwona Krela-Kaźmierczak, Aleksandra Szymczak, Liliana Łykowska-Szuber, Piotr Eder, Krzysztof Linke
Secondary osteoporosis occurs as an isolated pathology or co-exists with types I and II osteoporosis. The gastroenterologist may come across osteoporosis or osteopenia in a patient with a gastrointestinal disease. This is often a young patient in whom investigations should be carried out and appropriate treatment initiated, aimed at preventing bone fractures and the formation of the best peak bone mass. Osteoporosis occurs in patients with the following conditions: Crohn's disease, ulcerative colitis, celiac disease, post gastrectomy patients, patients with short bowel syndrome, chronic hepatitis and cirrhosis, treated with steroids (steroid-induced osteoporosis) and patients using proton pump inhibitors chronically (state of achlorhydria)...
January 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/26929019/efficacy-and-safety-of-minodronic-acid-hydrate-in-patients-with-steroid-induced-osteoporosis
#14
Noboru Kitamura, Hidetaka Shiraiwa, Hirotake Inomata, Takamasa Nozaki, Natsumi Ikumi, Kaita Sugiyama, Yousuke Nagasawa, Hiromi Karasawa, Mitsuhiro Iwata, Yoshihiro Matsukawa, Masami Takei
OBJECTIVES: Minodronic acid hydrate, an oral bisphosphonate, has a greater inhibitory effect on bone resorption than do other approved drugs; however, this has been studied only in patients with primary osteoporosis. Here, we administered minodronic acid hydrate to patients with steroid-induced osteoporosis who have been treated with steroids for rheumatoid arthritis or other collagen diseases, and the efficacy and safety of minodronic acid hydrate were prospectively investigated. METHODS: Twenty-five patients treated in our rheumatology clinic received minodronic acid hydrate 1 mg/day...
March 1, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/26881468/a-review-of-glucosamine-for-knee-osteoarthritis-why-patented-crystalline-glucosamine-sulfate-should-be-differentiated-from-other-glucosamines-to-maximize-clinical-outcomes
#15
Eugene J Kucharz, Volodymyr Kovalenko, Sándor Szántó, Olivier Bruyère, Cyrus Cooper, Jean-Yves Reginster
The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm for knee osteoarthritis (OA) recommends symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) first line for the medium to long term management of OA, due to their ability to control pain, improve function, and delay joint structural changes. Among SYSADOAs, glucosamine is probably the most widely used intervention. In the present review of glucosamine for knee OA, we have investigated whether the evidence is greater for the patented crystalline glucosamine sulfate (pCGS) preparation (Rottapharm/Meda) than for other glucosamine formulations...
June 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/26867651/acute-bilateral-uveitis-and-right-macular-edema-induced-by-a-single-infusion-of-zoledronic-acid-for-the-treatment-of-postmenopausal-osteoporosis-as-a-substitution-for-oral-alendronate-a-case-report
#16
Yiming Tian, Rui Wang, Lianyuan Liu, Chunming Ma, Qiang Lu, Fuzai Yin
BACKGROUND: Zoledronic acid-induced uveitis (ZAIU) is rare but severe, and has been recently considered part of an acute phase reaction. Only 15 cases have been reported since 2005. Here we describe a case with macular edema, which is the first reported case observed after long-term alendronate tolerance. CASE PRESENTATION: A 63-year-old Asian woman received her first intravenous zoledronic acid treatment for the management of postmenopausal osteoporosis as a more convenient substitute for oral alendronate...
2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/26842265/molecular-actions-of-glucocorticoids-in-cartilage-and-bone-during-health-disease-and-steroid-therapy
#17
REVIEW
Kerstin Hartmann, Mascha Koenen, Sebastian Schauer, Stephanie Wittig-Blaich, Mubashir Ahmad, Ulrike Baschant, Jan P Tuckermann
Cartilage and bone are severely affected by glucocorticoids (GCs), steroid hormones that are frequently used to treat inflammatory diseases. Major complications associated with long-term steroid therapy include impairment of cartilaginous bone growth and GC-induced osteoporosis. Particularly in arthritis, GC application can increase joint and bone damage. Contrarily, endogenous GC release supports cartilage and bone integrity. In the last decade, substantial progress in the understanding of the molecular mechanisms of GC action has been gained through genome-wide binding studies of the GC receptor...
April 2016: Physiological Reviews
https://www.readbyqxmd.com/read/26819354/comorbidity-in-severe-asthma-requiring-systemic-corticosteroid-therapy-cross-sectional-data-from-the-optimum-patient-care-research-database-and-the-british-thoracic-difficult-asthma-registry
#18
Joan Sweeney, Chris C Patterson, Andrew Menzies-Gow, Rob M Niven, Adel H Mansur, Christine Bucknall, Rekha Chaudhuri, David Price, Chris E Brightling, Liam G Heaney
OBJECTIVE: To determine the prevalence of systemic corticosteroid-induced morbidity in severe asthma. DESIGN: Cross-sectional observational study. SETTING: The primary care Optimum Patient Care Research Database and the British Thoracic Society Difficult Asthma Registry. PARTICIPANTS: Optimum Patient Care Research Database (7195 subjects in three age- and gender-matched groups)-severe asthma (Global Initiative for Asthma (GINA) treatment step 5 with four or more prescriptions/year of oral corticosteroids, n=808), mild/moderate asthma (GINA treatment step 2/3, n=3975) and non-asthma controls (n=2412)...
April 2016: Thorax
https://www.readbyqxmd.com/read/26732632/evaluation-of-safety-of-modified-danggui-buxue-tang-in-rodents-immunological-toxicity-and-hormonal-aspects
#19
Jian-Hui Xie, Zhi-Wei Chen, Ya-Wei Pan, De-Min Luo, Zi-Ren Su, Hai-Ming Chen, Zhen Qin, Shui-Qing Huang, Gao Lei
ETHNOPHARMACOLOGICAL RELEVANCE: Radix Astragali (RA), Radix Angelicae Sinensis (RAS) and Folium Epimedii (FE) are three of the extensively applied herbs among traditional Chinese medicines for gynecological disorders and osteoporosis. A derivative herbal formula-RRF, consisting of the three medicines with a weight ratio of 5:1:5, is derived from a famous Chinese herbal formula-Danggui Buxue Tang (DBT). RRF has shown noteworthy perimenopause ameliorating effect in both ovariectomized rats and natural aging female rats, which might represent a promising candidate for the treatment of perimenopausal disorders...
May 13, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26657825/multiscale-alterations-in-bone-matrix-quality-increased-fragility-in-steroid-induced-osteoporosis
#20
A Karunaratne, L Xi, L Bentley, D Sykes, A Boyde, C T Esapa, N J Terrill, S D M Brown, R D Cox, R V Thakker, H S Gupta
A serious adverse clinical effect of glucocorticoid steroid treatment is secondary osteoporosis, enhancing fracture risk in bone. This rapid increase in bone fracture risk is largely independent of bone loss (quantity), and must therefore arise from degradation of the quality of the bone matrix at the micro- and nanoscale. However, we lack an understanding of both the specific alterations in bone quality n steroid-induced osteoporosis as well as the mechanistic effects of these changes. Here we demonstrate alterations in the nanostructural parameters of the mineralized fibrillar collagen matrix, which affect bone quality, and develop a model linking these to increased fracture risk in glucocorticoid induced osteoporosis...
March 2016: Bone
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