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https://www.readbyqxmd.com/read/28925161/-protective-effects-of-liuwei-wuling-tablet-on-acute-alcoholic-induced-liver-injury-in-mice
#1
Ping Yin, He-Rong Cui, Cong-En Zhang, Yuan Zhang, Ya-Kun Meng, Lan-Zhi He, Hui-Min Liu, Xiu-Xiu Sang, Jia-Bo Wang, Zhao-Fang Bai, Xiao-He Xiao
The protective action and the relevant mechanism of Liuwei Wuling tablet on acute alcoholic hepatic injury in mice were investigated. All the C57BL/6 mice were divided randomly into 7 groups including blank, model, bifendate (150 mg•kg⁻¹, positive control) and experimental groups consisted of extremely low dose (0.1 g•kg⁻¹), low (0.5 g•kg⁻¹), upper (4 g•kg⁻¹) and high dose (8 g•kg⁻¹) of Liuwei Wuling tablet groups. The acute liver injury model was induced by modified method that the model, positive control and experimental groups were orally administrated 56% alcohol (6 g•kg⁻¹) twice at 12 hour intervals on the fifth day after drugs administration...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28902410/monascus-fermented-red-mold-dioscorea-protects-mice-against-alcohol-induced-liver-injury-while-its-metabolites-ankaflavin-and-monascin-regulates-ethanol-induced-ppar-%C3%AE-and-srebp-1-expression-in-hepg2-cells
#2
Chih-Fu Cheng, Tzu-Ming Pan
BACKGROUND: Alcoholic hepatitis is a necroinflammatory process that is associated with fibrosis and leads to cirrhosis in 40% of cases. The hepatoprotective effects of red mold dioscorea (RMD) from Monascus purpureus NTU 568 were evaluated in vivo using a mouse model of chronic alcohol-induced liver disease (ALD). RESULTS: ALD mice were orally administered vehicle (ALD group) or vehicle plus 307.5, 615.0, or 1537.5 mg kg(-1) (1×, 2×, and 5×) RMD for 5 weeks...
September 13, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28901345/-acute-alcoholic-hepatitis
#3
Gianni Testino, Emanuele Scafato, Valentino Patussi
Chronic alcohol related liver disease is characterized by a cascade of events defined as follows: steatosis, steatohepatitis/steatofibrosi, cirrhosis and hepatocellular carcinoma. On one of these histologic patterns may overlap acute alcoholic hepatitis (AAE) (mild, moderate, severe). Severe AAE can cause a severe clinical picture: jaundice with a duration of less than three months, jaundice in the first decompensation event, serum bilirubin higher than 5 mg/dL, ratio AST/ALT >2:1, AST less than 500 IU/L ALT <300 IU/L, neutrophil leukocytosis and increased GGT...
September 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28860788/impact-of-immunosuppressant-therapy-on-new-onset-diabetes-in-liver-transplant-recipients
#4
Fu-Chao Liu, Huan-Tang Lin, Jr-Rung Lin, Huang-Ping Yu
This nationwide, population-based study aimed to clarify the effects of immunosuppressive regimens on new-onset diabetes after liver transplantation (NODALT). The National Health Insurance database of Taiwan was explored for patients who received liver transplantation without pre-transplant diabetes from 1998 to 2012. Information regarding clinical conditions and immunosuppressant utilization among these patients was analyzed statistically. Of the 2,140 patients included in our study, 189 (8.8%) developed NODALT...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28856323/serratia-liquefaciens-infection-of-a-previously-excluded-popliteal-artery-aneurysm
#5
A Coelho, M Lobo, V Martins, R Gouveia, P Sousa, J Campos, R Augusto, N Coelho, A Canedo
INTRODUCTION: Popliteal artery aneurysms (PAAs) are rare in the general population, but they account for nearly 70% of peripheral arterial aneurysms. There are several possible surgical approaches including exclusion of the aneurysm and bypass grafting, or endoaneurysmorrhaphy and interposition of a prosthetic conduit. The outcomes following the first approach are favorable, but persistent blood flow in the aneurysm sac has been documented in up to one third of patients in the early post-operative setting...
2017: EJVES Short Rep
https://www.readbyqxmd.com/read/28818508/the-role-of-the-il-8-signaling-pathway-in-the-infiltration-of-granulocytes-into-the-livers-of-patients-with-alcoholic-hepatitis
#6
S W French, A S Mendoza, N Afifiyan, B Tillman, E Vitocruz, B A French
BACKGROUND AND AIM: IL-8 (C-X-L motif chemokine ligase 8) and CXCR2 (C-X-C-motif chemokine receptor 2) are up regulated in alcoholic hepatitis (AH) liver biopsies. One of the consequences is the attraction and chemotactic neutrophilic infiltrate seen at the AH stage of alcoholic liver disease. MATERIALS AND METHODS: Human formalin-fixed, paraffin-embedded (FFPE) liver biopsies from patients who have AH were studied by (2.1) RNA sequencing, (2.2) PCR and (2.3) semi quantitation of specific proteins in biopsy sections using immunohistochemical measurements of antibody fluorescent intensity with morphometric technology...
August 14, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28812994/organ-organ-crosstalk-and-alcoholic-liver-disease
#7
REVIEW
Lauren G Poole, Christine E Dolin, Gavin E Arteel
Alcohol consumption is a common custom worldwide, and the toxic effects of alcohol on several target organs are well-understood. Given the poor prognosis of treating clinically-relevant alcoholic liver disease (ALD) (i.e., alcoholic hepatitis (AH) and cirrhosis), additional research is required to develop more effective therapies. While the stages of ALD have been well-characterized, targeted therapies to prevent or reverse this process in humans are still needed. Better understanding of risk factors and mechanisms underlying disease progression can lead to the development of rational therapies to prevent or reverse ALD in the clinic...
August 16, 2017: Biomolecules
https://www.readbyqxmd.com/read/28776448/an-exploratory-genome-wide-analysis-of-genetic-risk-for-alcoholic-hepatitis
#8
James J Beaudoin, Nanye Long, Suthat Liangpunsakul, Puneet Puri, Patrick S Kamath, Vijay Shah, Arun J Sanyal, David W Crabb, Naga P Chalasani, Thomas J Urban
OBJECTIVES: To elucidate the genetic variability between heavy drinkers with and without alcoholic hepatitis (AH). MATERIALS AND METHODS: An exploratory genome-wide association study (GWAS; NCT02172898) was conducted comparing 90 AH cases with 93 heavy drinking matched controls without liver disease in order to identify variants or genes associated with risk for AH. Individuals were genotyped using the multi-ethnic genotyping array, after which the data underwent conventional quality control...
August 4, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28770701/cell-death-and-prognosis-of-mortality-in-alcoholic-hepatitis-patients-using-plasma-keratin-18
#9
Benjamin Woolbright, Brian Bridges, Winston Dunn, Jody Olson, Steven Weinman, Hartmut Jaeschke
Alcoholic liver disease encompasses the progressive stages of liver dysfunction that culminates in alcoholic cirrhosis(AC) and in severe cases alcoholic hepatitis (AH). Currently, prognostic scores have limited specificity and sensitivity. Plasma keratin-18 (K18) levels are elevated during liver disease and may be biomarkers of outcome. The objective of this study was to determine if total K18 (M65) or caspase-cleaved K18 (M30) levels were different between AC and AH patients. M65 and M30 levels were measured in plasma of consented healthy controls, and patients with AC and AH...
August 3, 2017: Gene Expression
https://www.readbyqxmd.com/read/28770495/fecal-microbiota-transplantation-beyond-clostridium-difficile
#10
REVIEW
Braden Millan, Michael Laffin, Karen Madsen
PURPOSE OF REVIEW: Fecal microbiota transplantation (FMT) has been established as standard of care in the treatment of antibiotic refractory Clostridium difficile infection (RCDI). This review examines the current evidence that exists to support the use of FMT in the treatment of human disease beyond C. difficile infection. RECENT FINDINGS: Beneficial effects of FMT have been described in case series or small prospective trials on a wide spectrum of conditions, including inflammatory bowel disease, functional gastrointestinal disorders, non-alcoholic steatohepatitis, alcoholic hepatitis, hepatic encephalopathy, and neuropsychiatric conditions, and in limiting antibiotic-resistant bacterial infections...
September 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28754919/pre-therapy-liver-transcriptome-landscape-in-indian-and-french-patients-with-severe-alcoholic-hepatitis-and-steroid-responsiveness
#11
Shvetank Sharma, Jaswinder S Maras, Sukanta Das, Shabir Hussain, Ashwani K Mishra, Saggere M Shasthry, Chhagan B Sharma, Emmanuel Weiss, Laure Elkrief, Pierre-Emmanuel Rautou, Hélène Gilgenkrantz, Sophie Lotersztajn, Valérie Paradis, Pierre de la Grange, Christophe Junot, Richard Moreau, Shiv K Sarin
Patients with severe alcoholic hepatitis (SAH) not responding to glucocorticoid therapy have higher mortality, though they do not differ in their baseline clinical characteristics and prognostic scores from those who respond to therapy. We hypothesized that the baseline hepatic gene expression differs between responders (R) and non-responders (NR). Baseline liver transcriptome was compared between R and NR in Indian (16 each) and French (5 NR, 3 R) patients with SAH. There were differentially expressed genes (DEGs) between NR and R, in Indian (1106 over-expressed, 96 under-expressed genes) and French patients (65 over-expressed, 142 under-expressed genes)...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28750768/circulating-levels-of-bacterial-dna-and-risk-of-infections-in-severe-alcoholic-hepatitis
#12
Alexandre Louvet
No abstract text is available yet for this article.
September 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28741287/redefining-successful-treatment-of-severe-alcoholic-hepatitis
#13
EDITORIAL
Michael Ronan Lucey
No abstract text is available yet for this article.
July 24, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28732370/silibinin-an-old-drug-for-hematological-disorders
#14
REVIEW
Hai Zou, Xing-Xing Zhu, Guo-Bing Zhang, Yuan Ma, Yi Wu, Dong-Sheng Huang
Silibinin (silybin), a non-toxic natural polyphenolic flavonoid, is the principal and the most biologically active component of silymarin. It is efficient in the treatment of acute and chronic liver disorders caused by toxins, drug, alcohol, hepatitis, and gall bladder disorders. Further, in our previous studies, we explored the anti-cancer efficacy in common cancers, such as lung, prostatic, colon, breast, bladder, as well as, hepatocellular carcinoma. Interestingly, silibinin is still not solely limited to the treatment of these diseases...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28698402/granulocyte-colony-stimulating-factor-treatment-in-non-alcoholic-fatty-liver-disease-beyond-marrow-cell-mobilization
#15
Ho Hyun Nam, Dae Won Jun, Kiseok Jang, Waqar Khalid Saeed, Jai Sun Lee, Hyeon Tae Kang, Yeon Ji Chae
Protective effects of granulocyte colony stimulating factor (G-CSF) in acute liver injury via marrow cell mobilization have been reported in several studies. But exact mode of action and optimal protocol of G-CSF has been still doubt in chronic disease. Here we investigated mode of action and optimization of G-CSF as a treatment for non-alcoholic fatty liver disease (NAFLD). Various doses of conventional G-CSF (30 μg/kg once weekly, once daily for 5 days, twice weekly) and long acting G-CSF (30 μg/kg once a month) were evaluated in two kinds of NAFLD animal models to optimize the G-CSF protocol...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28679322/prevalence-and-co-prevalence-of-comorbidities-in-belgian-patients-with-type-2-diabetes-mellitus-a-transversal-descriptive-study
#16
Michel P Hermans, Nicolas Dath
OBJECTIVES: Most patients with type 2 diabetes mellitus (T2DM) have at least one comorbid chronic disease. These comorbidities increase disease burden and costs and may impact the selection of glucose-lowering therapies. The aim of our study was to describe the prevalence and co-prevalence of comorbidities in patients with T2DM in Belgium. METHODS: This was a single centre, transversal, descriptive study performed at Saint-Luc University Hospital, Brussels, Belgium...
July 5, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28675278/-management-of-patients-with-alcoholic-hepatitis-why-can-t-we-do-better
#17
Justine Schwing, Caroline Bastid, Laurent Spahr
Alcoholic steatohepatitis is a severe and frequent manifestation of alcoholic liver disease which is associated with high mortality. This poor outcome is strongly influenced by several aspects of the disease, including the absence of medical treatment with proven benefit other than steroids, the elevated risk of infections, the ineffectiveneness of proregenerative strategies, the high prevalence of concomitant malnutrition, and the elevated rate of alcohol relapse during follow-up. All these parameters should be considered as major therapeutic targets in the near future in order to improve the management and outcome of these patients...
August 31, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28671334/alcoholic-hepatitis-continued-drinking-and-the-mourning-after
#18
Douglas A Simonetto, Patrick S Kamath, Vijay H Shah
No abstract text is available yet for this article.
July 3, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28654190/interobserver-variability-in-scoring-liver-biopsies-with-a-diagnosis-of-alcoholic-hepatitis
#19
Bela Horvath, Daniela Allende, Hao Xie, John Guirguis, Jennifer Jeung, James Lapinski, Deepa Patil, Arthur J McCullough, Srinivasan Dasarathy, Xiuli Liu
BACKGROUND: Alcoholic hepatitis (AH) is one of the most severe forms of alcoholic liver disease. Recently, a histologic scoring system for predicting prognosis in this patient cohort was proposed as Alcoholic Hepatitis Histologic Score (AHHS). We aimed to assess interobserver variability in recognizing histologic features of AH and the effect of this variability on the proposed AHHS categories. METHODS: Hematoxylin-eosin- and trichrome-stained slides from 32 patients diagnosed with AH with liver biopsies within 1 month of presentation (2000 to 2015) were reviewed by 5 pathologists including 3 liver pathologists and 2 gastrointestinal (GI) pathologists masked to the clinical findings or outcome...
June 27, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28647569/sepsis-in-alcohol-related-liver-disease
#20
REVIEW
Thierry Gustot, Javier Fernandez, Gyongyi Szabo, Agustin Albillos, Alexandre Louvet, Rajiv Jalan, Richard Moreau, Christophe Moreno
Alcohol-related liver disease (ALD) remains the most important cause of death due to alcohol. Infections, particularly bacterial infections, are one of the most frequent and severe complications of advanced ALDs, such as alcoholic cirrhosis and severe alcoholic hepatitis (sAH). The specific mechanisms responsible for this altered host defence are yet to be deciphered. The aim of the present study is to review the current knowledge of infectious complications in ALD and its pathophysiological mechanisms, distinguishing the role of alcohol consumption and the contribution of different forms of ALD...
June 22, 2017: Journal of Hepatology
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