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Orofacial Pain

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https://www.readbyqxmd.com/read/27911133/changes-in-cervical-movement-impairment-and-pain-following-orofacial-treatment-in-patients-with-chronic-arthralgic-temporomandibular-disorder-with-pain-a-prospective-case-series
#1
Francis Grondin, Toby Hall
The purpose of this study was to investigate the influence of isolated temporomandibular joint (TMJ) manual therapy on pain and range of motion (ROM) of the TMJ and cervical spine including flexion-rotation test (FRT) in people suffering chronic pain arising from chronic arthralgic temporomandibular disorder (TMD). An experienced clinician managed a case series of 12 patients with TMD (mean duration 28.6 months +/- 26.9). The intervention comprised four-weekly sessions of transverse medial accessory TMJ mobilization and advice...
December 2, 2016: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/27910899/glial-pannexin1-contributes-to-tactile-hypersensitivity-in-a-mouse-model-of-orofacial-pain
#2
Regina Hanstein, Menachem Hanani, Eliana Scemes, David C Spray
Drug studies in animal models have implicated pannexin1 (Panx1) in various types of pain, including trigeminal hypersensitivity, neuropathic pain and migraine. However, the tested drugs have limited specificity and efficacy so that direct evidence for Panx1 contribution to pain has been lacking. We here show that tactile hypersensitivity is markedly attenuated by deletion of Panx1 in a mouse model of chronic orofacial pain; in this model, trigeminal ganglion Panx1 expression and function are markedly enhanced...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900410/-%C3%AE-bisabolol-reduces-orofacial-nociceptive-behavior-in-rodents
#3
Luana Torres Melo, Mariana Araújo Braz Duailibe, Luciana Moura Pessoa, Flávio Nogueira da Costa, Antonio Eufrásio Vieira-Neto, Ana Paula de Vasconcellos Abdon, Adriana Rolim Campos
The purposes of this study were to evaluate the anti-nociceptive effect of oral and topical administration of (-)-α-bisabolol (BISA) in rodent models of formalin- or cinnamaldehyde-induced orofacial pain and to explore the inhibitory mechanisms involved. Orofacial pain was induced by injecting 1.5% formalin into the upper lip of mice (20 μL) or into the temporomandibular joint (TMJ) of rats (50 μL). In another experiment, orofacial pain was induced with cinnamaldehyde (13.2 μg/lip). Nociceptive behavior was proxied by time (s) spent rubbing the injected area and by the incidence of head flinching...
November 29, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27891301/how-far-have-we-come-in-the-field-of-nerve-regeneration-after-trigeminal-nerve-injury
#4
REVIEW
Annika Rosén, Arezo Tardast, Tie-Jun Shi
Patients suffering from nerve injury with sensory disturbances or orofacial pain have greatly reduced quality of life, and it is a big cost for the society. Abnormal sensations caused by trigeminal nerve injury often become chronic, severely debilitating, and extremely difficult to treat. In general, non-invasive treatment such as drug treatment has been insufficient, and there are currently few available effective treatments. Surgical interventions such as end-to-end connection or nerve grafting have disadvantages such as donor site morbidity or formation of neuroma...
2016: Current Oral Health Reports
https://www.readbyqxmd.com/read/27865869/erk-potentiates-p38-in-central-sensitization-induced-by-traumatic-occlusion
#5
Lei Jing, Xiao-Dong Liu, Hong-Xu Yang, Mian Zhang, Ying Wang, Li Duan, Jing Zhang, Lei Lu, Ting Yang, Dong-Mei Wang, Liang-Wei Chen, Mei-Qing Wang
This study was to investigate the role of p38 activation via ERK1/2 phosphorylation in neurons and microglia of the spinal trigeminal subnucleus caudalis (Vc) in the promotion of orofacial hyperalgesia induced by unilateral anterior crossbite (UAC) traumatic occlusion in adult rats. U0126, a p-ERK1/2 inhibitor, was injected intracisternally before UAC implant. The effects of the U0126 injection were compared to those following the injection of SB203580, a p-p38 inhibitor. Mechanical hyperalgesia was evaluated via pressure pain threshold measurements...
November 16, 2016: Neuroscience
https://www.readbyqxmd.com/read/27858874/the-analgesic-effect-of-therapeutic-rtms-is-not-mediated-or-predicted-by-comorbid-psychiatric-or-sleep-disorders
#6
Pauliina Lindholm, Salla Lamusuo, Tero Taiminen, Arja Virtanen, Antti Pertovaara, Heli Forssell, Nora Hagelberg, Satu Jääskeläinen
BACKGROUND: Mechanisms underlying alleviation of neuropathic pain by repetitive transcranial magnetic stimulation (rTMS) of primary motor cortex (M1) and right secondary somatosensory cortex (S2) are only partly known. Patients with chronic neuropathic pain often have comorbidities like depression and sleep problems. Through functional connectivity, rTMS of M1 and S2 may activate dorsolateral prefrontal cortex, the target for treating depression with rTMS. Thus, the analgesic effect of rTMS could be mediated indirectly via improvement of psychiatric comorbidities or sleep...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27856965/hedgehog-pathway-mediated-vascular-alterations-following-trigeminal-nerve-injury
#7
N Moreau, W Dieb, A Mauborgne, S Bourgoin, L Villanueva, M Pohl, Y Boucher
Whereas neurovascular interactions in spinal neuropathic pain models have been well characterized, little attention has been given to such neurovascular interactions in orofacial neuropathic pain models. This study investigated in male Sprague-Dawley rats the vascular changes following chronic constriction injury (CCI) of the infraorbital nerve (IoN), a broadly validated preclinical model of orofacial neuropathic pain. Following IoN-CCI, an early downregulation of tight junction proteins Claudin-1 and Claudin-5 was observed within the endoneurium and perineurium, associated with increased local accumulation of sodium fluorescein (NaFlu) within the IoN parenchyma, as compared with sham animals...
November 16, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27836326/diabetes-mellitus-influences-the-expression-of-npy-and-vegf-in-neurons-of-rat-trigeminal-ganglion
#8
Milka Jerić, Katarina Vukojević, Ana Vuica, Natalija Filipović
BACKGROUND: Diabetes mellitus (DM) influences the trigeminal nerve function by changing the pain response and transduction of the orofacial sensory pathways. It affects the inflammatory response via neuropeptide Y (NPY) and vascular endothelial growth factor (VEGF), which could potentially have a relevant role in the pathophysiology of diabetic neuropathy. The aim was to investigate expression of VEGF and NPY in subpopulations of trigeminal ganglion (TG) neurons in rat models of early DM1 and DM2...
November 3, 2016: Neuropeptides
https://www.readbyqxmd.com/read/27834414/psychosocial-aspects-and-temporomandibular-disorders-in-dental-students
#9
Cibele Oliveira de Melo Rocha, Raniel Fernandes Peixoto, Camila Maria Bastos Machado Resende, Arthur César de Medeiros Alves, Ângelo Giuseppe Roncalli da Oliveira, Gustavo Augusto Seabra Barbosa
OBJECTIVE: Dental students have high levels of anxiety that can affect not only academic performance but also increase the risk for other diseases. It is believed that the increase in the incidence of chronic orofacial pain in temporomandibular disorders (TMDs) may have an impact on the quality of life and general health of subjects. The aim of this study was to evaluate the prevalence of TMD in dental students and its association with general health, quality of life, and anxiety. METHOD AND MATERIALS: Ninety students were evaluated by four questionnaires to determine the prevalence and severity of TMD (Fonseca's questionnaire) and to quantify general health (General Health Questionnaire - GHQ), quality of life (World Health Organization Quality of Life - Brief version - WHOQOL-brief) and anxiety levels (State-Trait Anxiety Index - STAI)...
November 10, 2016: Quintessence International
https://www.readbyqxmd.com/read/27834409/-multidisciplinary-treatment-of-orofacial-pain
#10
J W Geurts, J Haumann, M van Kleef
The diagnosis and treatment of orofacial pain can be complex. The differential diagnosis is very extensive. Therefore, multidisciplinary diagnosis and treatment are often indicated. The diagnosis of chronic pain also entails the investigation of psychological factors. This is because psychological problems can play a role in the chronification of pain, but they can also be a consequence of chronic pain. Patients with persistent orofacial complaints should be seen by a medical team consisting of an oral and maxillofacial surgeon, a neurologist, an anaesthesiologist/pain specialist, a dentist-gnathologist, an orofacial physical therapist, and a psychologist or psychiatrist specialising in orofacial pain...
November 2016: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/27834407/-painful-temporomandibular-dysfunctions-diagnosis-and-treatment
#11
F Lobbezoo, G Aarab, W Knibbe, M Koutris, C J Warnsinck, P Wetselaar, C M Visscher
Painful temporomandibular disorders (TMD pain) are common among the general population. The most common sub diagnoses are myalgia (jaw-muscle pain) and arthralgia (temporomandibular joint pain). The aetiology of TMD pain has a multifactorial nature, and its diagnosis and possible treatment often require a multidisciplinary approach. The most recent insights in the diagnosis and treatment of TMD pain are based on the multidisciplinary guideline 'Chronic Orofacial Pain' that was developed by the Dutch Society of Headache Patients and was published in 2013...
November 2016: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/27834406/-complaints-of-pain-in-the-orofacial-area-of-non-odontogenic-origin
#12
B Stegenga
Complaints of pain in the orofacial area usually are odontogenic in origin or have to do with temporomandibular dysfunction. Dentists can, nevertheless, be confronted with a number of disorders that are non-odontogenic in nature. In such instances it is not always a matter of nociceptive pain, associated with somatic damage, but the pain can also be the result of nerve damage (neuropathic pain) or of changes that may occur within the central nervous system (central sensitisation). In most of these cases, the pain is chronic in nature...
November 2016: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/27796174/temporomandibular-disorders-and-quality-of-life-among-12-year-old-schoolchildren
#13
Marina de Faria da Silva, Silvia A S Vedovello, Mario Vedovello Filho, Giovana C Venezian, Heloísa C Valdrighi, Viviane V Degan
OBJECTIVES: The aim of this study was to investigate the association between symptoms of temporomandibular disorders (TMD), quality of life, and malocclusion. METHODS: A cross-sectional observational design study was utilized among 248 schoolchildren aged 12 years old. Symptoms of TMD were assessed using the Orofacial Pain and Temporomandibular Disorders Triage Questionnaire, and subjects were further evaluated as oral-health-related quality of life (CPQ11-14), tooth clenching/grinding and malocclusion (Dental Aesthetic Index)...
October 31, 2016: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/27792802/assessment-of-mechanical-pain-thresholds-in-the-orofacial-region-a-comparison-between-pinprick-stimulators-and-electronic-von-frey-device
#14
Kayo Suzuki, Lene Baad-Hansen, Maria Pigg, Peter Svensson
AIMS: To compare mechanical pain thresholds (MPTs) in the orofacial region assessed with two different approaches: with an electronic von Frey (EvF) device and with custom-made weighted pinprick stimulators. The test-retest reliability, variability of MPTs, and time duration of each test were also compared, as well as the ability of each test to create stimulus-response (S-R) curves. METHODS: A total of 16 healthy volunteers participated. The MPT and S-R curve measurements were done with the two different techniques at three sites: on the skin of the right cheek (face), on the buccal gingival mucosa of the right upper premolar region (gingiva), and on the tip of the tongue (tongue)...
October 2016: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/27789649/persistent-idiopathic-facial-pain-a-prospective-systematic-study-of-clinical-characteristics-and-neuroanatomical-findings-at-3-0-tesla-mri
#15
Stine Maarbjerg, Frauke Wolfram, Tone Bruvik Heinskou, Per Rochat, Aydin Gozalov, Jannick Brennum, Jes Olesen, Lars Bendtsen
INTRODUCTION: Persistent idiopathic facial pain (PIFP) is a poorly understood chronic orofacial pain disorder and a differential diagnosis to trigeminal neuralgia. To address the lack of systematic studies in PIFP we here report clinical characteristics and neuroimaging findings in PIFP. METHODS: Data collection was prospective and standardized in consecutive PIFP patients. All patients underwent 3.0 MRI. RESULTS: In a cohort of 53 PIFP patients, the average age of onset was 44...
October 27, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27786149/temporomandibular-disorder-in-otolaryngology-systematic-review
#16
L Stepan, C-K L Shaw, S Oue
BACKGROUND: Temporomandibular disorder poses a diagnostic challenge to otolaryngologists as orofacial pain, headache and otology symptoms are very common in temporomandibular disorder, and mimic a number of otolaryngological conditions. Missed diagnosis of temporomandibular disorder can lead to unnecessary investigation and treatment, resulting in further patient suffering. OBJECTIVES: To review the current literature and propose management pathways for otolaryngologists to correctly differentiate temporomandibular disorder from other otolaryngological conditions, and to initiate effective treatment for temporomandibular disorder in collaboration with other health professionals...
October 27, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27776466/persistent-orofacial-muscle-pain-its-synonymous-terminology-and-presentation
#17
Egilius L H Spierings, Maxim J H L Mulder
OBJECTIVE: The purpose of the present paper is to describe the presentation of persistent orofacial muscle pain, also commonly referred to as myofascial temporomandibular disorder. METHODS: In this practice survey, the authors reviewed the demographic and clinical features of 34 patients who were evaluated and diagnosed personally. RESULTS: The majority of the 34 patients were women (82.4%), and their age at consultation averaged 44.6 ± 12...
October 24, 2016: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/27770480/agreement-between-quantitative-and-qualitative-sensory-testing-of-changes-in-oro-facial-somatosensory-sensitivity
#18
J Agbaje, A De Laat, P Constantinus, P Svensson, L Baad-Hansen
Qualitative somatosensory testing (QualST) is a simple chairside test. It can be used to roughly assess the presence or absence of altered somatosensory function. To use QualST clinically, it is important to assess its agreement with quantitative sensory testing (QST). The aims of this study were to assess the agreement between QST and QualST when testing the modulation of facial sensitivity by capsaicin in healthy participants and to explore the agreement between QST and QualST in assessing the intraoral sensory function in clinical atypical odontalgia (AO) patients...
October 22, 2016: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/27770441/effect-of-static-magnetic-field-on-pain-level-and-expression-of-p2x3-receptors-in-the-trigeminal-ganglion-in-mice-following-experimental-tooth-movement
#19
Yafen Zhu, Shengguo Wang, Hu Long, Jingyi Zhu, Fan Jian, Niansong Ye, Wenli Lai
Recent research has demonstrated that static magnetic fields (SMF) can generate an analgesic effect in different conditions. The present study explored effects of SMF on pain levels and expressions of P2X3 receptors in trigeminal ganglion (TG) in mice after experimental tooth movement (tooth movement induced by springs between teeth). Experiments were performed in male mice (body mass: 25-30 g) and divided into SMF + force group, force group, and no force group. Exposure time was over 22 h per day. Mouse Grimace Scale was used for evaluating orofacial pain levels during experimental tooth movement at 4 h and 1, 3, 7, and 14 days...
October 21, 2016: Bioelectromagnetics
https://www.readbyqxmd.com/read/27752210/a-comparative-study-of-trigger-point-therapy-with-local-anaesthetic-0-5%C3%A2-bupivacaine-versus-combined-trigger-point-injection-therapy-and-levosulpiride-in-the-management-of-myofascial-pain-syndrome-in-the-orofacial-region
#20
Pranav Gupta, Virendra Singh, Sujata Sethi, Arun Kumar
AIM: To compare the efficacy of combined local anesthetic injection with 0.5 % bupivacaine and levosulpiride versus local anesthetic injection alone on outcome measures including levels of pain intensity and depression in the management of myofascial pain syndrome in orofacial region. PATIENTS AND METHODS: This was a prospective, randomized, controlled and open-label comparative clinical study. Seventy-four patients diagnosed to have myofascial pain syndrome and fulfilling the inclusion criteria were enrolled for the study...
September 2016: Journal of Maxillofacial and Oral Surgery
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