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Orofacial Pain

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https://www.readbyqxmd.com/read/28738105/psychosocial-and-behavioral-aspects-of-pain-and-perception-of-oral-health
#1
Miriane Lucindo Zucoloto, João Maroco, Juliana Alvares Campos
AIMS: To evaluate the contribution of the psychosocial and behavioral aspects of pain to the perception of oral health in a sample of Brazilian dental patients. METHODS: This cross-sectional study involved 436 patients who sought dental care in the School of Dentistry of São Paulo State University and who reported some type of orofacial pain. The study group's mean age (± standard deviation [SD]) was 39.9 ± 13.6 years, and the sample was 74.5% female. The Portuguese version of the Oral Health Impact Profile Short Form (OHIP-14) and the Multidimensional Pain Inventory (MPI) were used...
July 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28724785/orthodontic-treatment-induced-temporal-alteration-of-jaw-opening-reflex-excitability
#2
Au Sasaki, Naoya Hasegawa, Kazunori Adachi, Hiroshi Sakagami, Naoto Suda
The impairment of orofacial motor function during orthodontic treatment is need to be addressed, since most of orthodontic patients experience pain and motor excitability would be affected by pain. In the present study, the temporal alteration of the jaw-opening reflex excitability was investigated to determine if orthodontic treatment affects orofacial motor function. The excitability of jaw-opening reflex evoked by electrical stimulation on the gingiva and recorded bilaterally in the anterior digastric muscles was evaluated at one (D1), three (D3) and seven (D7) days after orthodontic force application to the teeth of right side, morphological features (e...
July 19, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28706450/reactive-oxygen-species-increase-neuronal-excitability-via-activation-of-nonspecific-cation-channel-in-rat-medullary-dorsal-horn-neurons
#3
Hae In Lee, Byung Rim Park, Sang Woo Chun
The caudal subnucleus of the spinal trigeminal nucleus (medullary dorsal horn; MDH) receives direct inputs from small diameter primary afferent fibers that predominantly transmit nociceptive information in the orofacial region. Recent studies indicate that reactive oxygen species (ROS) is involved in persistent pain, primarily through spinal mechanisms. In this study, we aimed to investigate the role of xanthine/xanthine oxidase (X/XO) system, a known generator of superoxide anion (O2(·-)), on membrane excitability in the rat MDH neurons...
July 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28704800/inclusion-complex-between-%C3%AE-cyclodextrin-and-hecogenin-acetate-produces-superior-analgesic-effect-in-animal-models-for-orofacial-pain
#4
Yasmim M B G Carvalho, Paula P Menezes, Bruna M H Sousa, Bruno S Lima, Igor A S Trindade, Mairim R Serafini, Erik W M Pereira, Marilia M Rezende, Jullyana S S Quintans, Lucindo J Quintans-Júnior, Celso V Nakamura, Edeildo F Silva-Júnior, Alessandre C Crispim, Thiago M Aquino, Adriano A S Araújo
Hecogenin acetate (HA) is a steroidal sapogenin-acetylated with pharmacological properties which have already been described in the literature such as, anti-inflammatory, anti-hyperalgesic and antinociceptive, but it has low solubility in aqueous media. Therefore, in an attempt to overcome this, we set out to create inclusion complexes between HA and b-cyclodextrin (b-CD) and evaluate the antinociceptive effects in the orofacial nociception in mice. The complexes were prepared using different methods in the molar ratios 1:1 and 1:2 and characterized physicochemically...
July 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28701861/a-preliminary-genome-wide-association-study-of-pain-related-fear-implications-for-orofacial-pain
#5
Cameron L Randall, Casey D Wright, Jonathan M Chernus, Daniel W McNeil, Eleanor Feingold, Richard J Crout, Katherine Neiswanger, Robert J Weyant, John R Shaffer, Mary L Marazita
BACKGROUND: Acute and chronic orofacial pain can significantly impact overall health and functioning. Associations between fear of pain and the experience of orofacial pain are well-documented, and environmental, behavioral, and cognitive components of fear of pain have been elucidated. Little is known, however, regarding the specific genes contributing to fear of pain. METHODS: A genome-wide association study (GWAS; N = 990) was performed to identify plausible genes that may predispose individuals to various levels of fear of pain...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/28697954/antinociceptive-action-of-nop-and-opioid-receptor-agonists-in-the-mouse-orofacial-formalin-test
#6
A Rizzi, C Ruzza, S Bianco, C Trapella, G Calo'
Nociceptin/orphanin FQ (N/OFQ) modulates several biological functions, including pain transmission via selective activation of a specific receptor named NOP. The aim of this study was the investigation of the antinociceptive properties of NOP agonists and their interaction with opioids in the trigeminal territory. The orofacial formalin (OFF) test in mice was used to investigate the antinociceptive potential associated to the activation of NOP and opioid receptors. Mice subjected to OFF test displayed the typical biphasic nociceptive response and sensitivity to opioid and NSAID drugs...
July 8, 2017: Peptides
https://www.readbyqxmd.com/read/28664577/the-medial-pterygoid-muscle-a-stabilizer-of-horizontal-jaw-movement
#7
Hui Chen, Terry Whittle, John A Gal, Greg M Murray, Iven J Klineberg
There is limited information of the normal function of the human medial pterygoid muscle (MPt). The aims were to determine whether (a) the MPt is active throughout horizontal jaw movements with the teeth apart and (b) whether single motor units (SMUs) are active during horizontal and opening - closing jaw movements. Intramuscular electrodes were placed in the right MPt of 18 participants who performed 5 teeth-apart tasks: 1) postural position, 2) ipsilateral (i.e. right) jaw movement, 3) contralateral movement, 4) protrusive movement, 5) opening-closing movement...
June 29, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28653747/pharmacological-treatment-of-orofacial-pain-health-technology-assessment-including-a-systematic-review-with-network-meta-analysis
#8
REVIEW
B Häggman-Henrikson, P Alstergren, T Davidson, Ed Högestätt, P Östlund, S Tranaeus, S Vitols, T List
This health technology assessment evaluated the efficacy of pharmacological treatment in patients with orofacial pain. Randomised controlled trials were included if they reported pharmacological treatment in patients ≥18 years with chronic (≥3 months) orofacial pain. Patients were divided into subgroups: TMD-muscle [Temporomandibular disorders (TMD) mainly associated with myalgia]; TMD-joint (TMD mainly associated with temporomandibular joint pain); and Burning mouth syndrome (BMS). The primary outcome was pain intensity reduction after pharmacological treatment...
June 27, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28643911/effects-of-cocoa-enriched-diet-on-orofacial-pain-in-a-murine-model
#9
L N Bowden, E L Rohrs, K Omoto, P L Durham, L S Holliday, A D Morris, K D Allen, R M Caudle, J K Neubert
OBJECTIVES: To investigate and discuss the effects of cocoa on orofacial pain. SETTING AND SAMPLE POPULATION: The Department of Orthodontics at the University of Florida (UF). Male and female hairless rats (N=20/group) were tested. MATERIALS AND METHODS: Rats were tested using the Orofacial Pain Assessment Device (OPAD) before and after changing their food from the standard chow to a cocoa-enriched or control-equivalent diet. RESULTS: Male rats fed the cocoa diet had a significantly higher operant pain index when tested at 37°C as compared to control diet-fed animals...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28638895/chronic-orofacial-pain-burning-mouth-syndrome-and-other-neuropathic-disorders
#10
Raymond C Tait, McKenzie Ferguson, Christopher M Herndon
Chronic orofacial pain is a symptom associated with a wide range of neuropathic, neurovascular, idiopathic, and myofascial conditions that affect a significant proportion of the population. While the collective impact of the subset of the orofacial pain disorders involving neurogenic and idiopathic mechanisms is substantial, some of these are relatively uncommon. Hence, patients with these disorders can be vulnerable to misdiagnosis, sometimes for years, increasing the symptom burden and delaying effective treatment...
March 2017: Journal of Pain Management & Medicine
https://www.readbyqxmd.com/read/28637974/neuron-glia-interaction-is-a-key-mechanism-underlying-persistent-orofacial-pain
#11
Koichi Iwata, Ayano Katagiri, Masamichi Shinoda
Excitability of neurons in the trigeminal ganglion (TG), trigeminal spinal subnucleus caudalis (Vc), and upper cervical spinal cord (C1-C2) is greatly enhanced after orofacial inflammation and trigeminal nerve injury, and TG, Vc, and C1-C2 neurons remain sensitized long after such episodes. Sensitized neurons generate various molecules, which are released from nociceptive neurons in these areas and are involved in modulating the excitability of TG, Vc, and C1-C2 nociceptive neurons. Hyperexcitable nociceptive neurons also activate satellite glial cells in the TG and microglial cells and astrocytes in the Vc and C1-C2...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28622208/duloxetine-plasma-concentrations-and-its-effectiveness-in-the-treatment-of-nonorganic-chronic-pain-in-the-orofacial-region
#12
Yuka Kobayashi, Wataru Nagashima, Tatsuya Tokura, Keizo Yoshida, Eri Umemura, Tomoya Miyauchi, Munetaka Arao, Mikiko Ito, Hiroyuki Kimura, Kenichi Kurita, Norio Ozaki
OBJECTIVE: The purpose of this study was to examine the relationship between the pain-relieving effects of duloxetine and its plasma concentrations in patients with burning mouth syndrome and atypical odontalgia characterized by chronic nonorganic pain in the orofacial region. METHODS: We administered duloxetine to 77 patients diagnosed as having burning mouth syndrome or atypical odontalgia for 12 weeks. The initial dose of duloxetine was established as 20 mg/d and was increased to 40 mg/d after week 2...
July 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28622039/determinants-for-craniofacial-pains-in-children-6-8-years-of-age-the-panic-study
#13
Anu Vierola, Anna Liisa Suominen, Aino-Maija Eloranta, Niina Lintu, Tiina Ikävalko, Matti Närhi, Timo A Lakka
OBJECTIVE: Determinants for orofacial pain, headache, morning headache and painful signs of temporomandibular disorders (TMD) were investigated in prepubertal children. MATERIAL AND METHODS: The participants were a population sample of 439 children aged 6-8 years. Craniofacial pains, eating meals and snacks, sleep bruxism, sleep quality, sleep-disordered breathing (SDB), psychological well-being, parental education and household income were assessed by questionnaires filled out by the parents...
June 16, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28588616/a-comparison-of-impact-of-chronic-periodontal-diseases-and-nonsurgical-periodontal-therapy-on-oral-health-related-quality-of-life
#14
Khushboo Goel, Dharnidhar Baral
OBJECTIVES: To evaluate the impact of chronic periodontal diseases (PDs) and compare phases of nonsurgical periodontal therapy (NSPT) on oral health-related quality of life (OHRQoL) in patients attending a tertiary care center of eastern Nepal. MATERIALS AND METHODS: Matched for socioeconomic status, participants were recruited in two groups: moderate-to-severe chronic periodontitis (n = 24, 43 ± 46 years) and chronic gingivitis (n = 25, 30 ± 96 years). The treatment modalities were scaling and root surface debridement (RSD) and supragingival scaling, respectively...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28554268/knowledge-and-competence-in-temporomandibular-disorders-among-swedish-general-dental-practitioners-and-dental-hygienists
#15
Maja Gnauck, Tomas Magnusson, EwaCarin Ekberg
OBJECTIVE: The aim of this study was to investigate knowledge and competence in temporomandibular disorders (TMD) among dentists and dental hygienists working in the public dental service (PDS) in Sweden. MATERIALS AND METHODS: The study population comprised all general dentists (n = 110) and dental hygienists (n = 80) working in the PDS in two Swedish counties: Kronoberg (K) and Blekinge (B). The participants filled out a questionnaire comprised of 15 questions...
May 29, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28553411/knowledge-about-chronic-orofacial-pain-among-general-dentists-of-kermanshah-iran
#16
Fatemeh Rezaei, Roohollah Sharifi, Hamid R Shahrezaee, Hamid R Mozaffari
BACKGROUND AND OBJECTIVE: Diagnosis and treatment of chronic orofacial pain are one of the most challenging issues in dentistry. The purpose of this study was to assess the knowledge of general dentists regarding orofacial pain in Kermanshah, Iran. METHODS: This cross-sectional study was conducted in 2016 including general dentists of Kermanshah city. A researcher-designed questionnaire was administered to collect demographic data as well as measuring knowledge of the dentists in four sections including etiology, clinical presentations, physical examination, and treatment of chronic orofacial pain...
2017: Open Dentistry Journal
https://www.readbyqxmd.com/read/28549561/lateral-thalamic-control-of-nociceptive-response-after-whisker-pad-injection-of-varicella-zoster-virus
#17
Phillip R Kramer, Crystal Stinson, Mikhail Umorin, Mohong Deng, Mahesh Rao, Larry L Bellinger, Michael B Yee, Paul R Kinchington
Pain is a common complication of herpes zoster (HZ) infection which results from reactivation of a latent varicella zoster virus (VZV). A third of HZ patients' progress to a chronic pain state known as post herpetic neuralgia (PHN), and about a quarter of these patients' have orofacial pain. The mechanisms controlling the pain responses are not understood. Studies suggest central pathways involving the thalamus could control pain related to HZ, and studies in our lab suggest (VGAT) in the lateral thalamus influences orofacial pain...
July 25, 2017: Neuroscience
https://www.readbyqxmd.com/read/28549330/impact-of-post-traumatic-stress-disorder-on-oral-health
#18
Ana Cristina de Oliveira Solis, Álvaro Cabral Araújo, Felipe Corchs, Marcio Bernik, Érica Panzani Duran, Cláudio Silva, Francisco Lotufo-Neto
BACKGROUND: The stress experienced as an intense and traumatic event can increase the odds of orofacial pain, affect the biomechanics of masticatory system and compromise the periodontal health. This study was conducted to investigate the impact of post-traumatic stress disorder (PTSD) on oral health. METHODS: A case-control study with a convenience sample was designed. Probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing, and plaque were recorded at 6 sites per tooth...
May 20, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28542026/combination-drug-therapy-of-pioglitazone-and-d-cycloserine-attenuates-chronic-orofacial-neuropathic-pain-and-anxiety-by-improving-mitochondrial-function-following-trigeminal-nerve-injury
#19
Danielle N Lyons, Liping Zhang, Jignesh D Pandya, Robert J Danaher, Fei Ma, Craig S Miller, Patrick G Sullivan, Cristian Sirbu, Karin N Westlund
OBJECTIVES: The study aim was to determine how peripheral trigeminal nerve injury affects mitochondrial respiration and to test efficacy of combined treatment with two FDA approved drugs with potential for improving mitochondrial bioenergetics, pain and anxiety related behaviors in a chronic orofacial neuropathic pain mouse model. METHODS: Efficacy of (R)-(+)-4-amino-3-isoxazolidinone (D-cycloserine, DCS), an NMDA antagonist/agonist, and Pioglitazone (PIO), a selective agonist of nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) was investigate in the trigeminal inflammatory compression (TIC) neuropathic nerve injury mouse model...
May 24, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28536539/mental-status-as-a-common-factor-for-masticatory-muscle-pain-a-systematic-review
#20
REVIEW
Mieszko Wieckiewicz, Marek Zietek, Joanna Smardz, Dobrochna Zenczak-Wieckiewicz, Natalia Grychowska
Masticatory muscle pain (MMP) is the primary reason for chronic non-odontogenic orofacial pain in the human population. MMP has become a considerable social problem, which affects about 12-14% of the adult population and is 1.5-2 times more frequent in women than in men. This term defines a pain which has its origins in the masticatory muscles. Although MMP is typically felt in the face, jaws, and preauricular area, MMP can radiate to the ear, teeth, head, and neck. This systematic review explains the relationship between MMP and common mental states, such as anxiety, depression, mood and stress-related disorders, and is reported in accordance with PRISMA guidelines...
2017: Frontiers in Psychology
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