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Orofacial Pain

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https://www.readbyqxmd.com/read/29331791/magnesium-sulfate-reduces-formalin-induced-orofacial-pain-in-rats-with-normal-magnesium-serum-levels
#1
Dragana P Srebro, Sonja M Vučković, Ivan S Dožić, Branko S Dožić, Katarina R Savić Vujović, Aleksandar P Milovanović, Branislav V Karadžić, Milica Š Prostran
BACKGROUND: In humans, orofacial pain has a high prevalence and is often difficult to treat. Magnesium is an essential element in biological a system which controls the activity of many ion channels, neurotransmitters and enzymes. Magnesium produces an antinociceptive effect in neuropathic pain, while in inflammatory pain results are not consistent. We examined the effects of magnesium sulfate using the rat orofacial formalin test, a model of trigeminal pain. METHODS: Male Wistar rats were injected with 1...
August 31, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29329029/corrigendum-to-pharmacological-profile-of-dexketoprofen-in-orofacial-pain-pharmacol-rep-68-6-2016-1111-1114
#2
Hugo F Miranda, Fernando Sierralta, Nicolás Aranda, Viviana Noriega, Juan Carlos Prieto
No abstract text is available yet for this article.
January 9, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29324076/brain-functional-changes-before-during-and-after-clinical-pain
#3
X Hu, A J Racek, E Bellile, T D Nascimento, M C Bender, R L Toback, D Burnett, L Khatib, R McMahan, I Kovelman, R P Ellwood, A F DaSilva
This study used an emerging brain imaging technique, functional near-infrared spectroscopy (fNIRS), to investigate functional brain activation and connectivity that modulates sometimes traumatic pain experience in a clinical setting. Hemodynamic responses were recorded at bilateral somatosensory (S1) and prefrontal cortices (PFCs) from 12 patients with dentin hypersensitivity in a dental chair before, during, and after clinical pain. Clinical dental pain was triggered with 20 consecutive descending cold stimulations (32° to 0°C) to the affected teeth...
January 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29320883/the-prevalence-of-oral-stage-dysphagia-in-adults-presenting-with-temporomandibular-disorders-a-systematic-review-and-meta-analysis
#4
Órla Gilheaney, Sibylle Béchet, Patrick Kerr, Ciaran Kenny, Shauna Smith, Rita Kouider, Rachel Kidd, Margaret Walshe
OBJECTIVE: Temporomandibular disorders (TMDs) are the most commonly experienced non-dental orofacial pain disorders, with pain and dysfunction potentially resulting in oral stage dysphagia (OD). However, limited research has been conducted on this condition, with potential negative effects on clinical practice. Therefore, the aim of this study was to determine the prevalence of OD in adults presenting with TMDs, diagnosed as per the Research Diagnostic Criteria for Temporomandibular Disorders or the Diagnostic Criteria for Temporomandibular Disorders protocols...
January 11, 2018: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29315419/the-effect-of-obesity-on-orofacial-pain-during-early-orthodontic-treatment-with-fixed-appliances-a-prospective-cohort-study
#5
Hayder F Saloom, Spyridon N Papageorgiou, Guy H Carpenter, Martyn T Cobourne
Introduction: We have investigated orofacial pain in a prospective cohort of obese and normal-weight subjects undergoing fixed-appliance orthodontic treatment. Methods: Fifty-five subjects (27 males, 28 females) mean age 15.1 (1.6) years and mean body mass index 30.2 (3.5) in obese and 19.4 (2.2) kg/m2 in normal-weight groups were followed for 1 week after appliance placement. Primary outcome was maximum-pain measured using a 100-mm visual analogue scale. Secondary outcomes included mean pain and oral analgesic consumption...
October 9, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29313436/down-regulation-of-kv4-3-channels-and-a-type-k-currents-in-v2-trigeminal-ganglion-neurons-of-rats-following-oxaliplatin-treatment
#6
Viacheslav Viatchenko-Karpinski, Jennifer Ling, Jianguo G Gu
Chemotherapy drugs such as oxaliplatin can increase nociceptive neuron excitability to result in neuropathic pain in orofacial and other regions in patients following chemotherapy. However, mechanisms underlying chemotherapy-induced increases of nociceptive neuron excitability are not fully understood. Kv4.3 channels are voltage-gated K+ channels mediating A-type K+ (IA) currents to control neuronal excitability. In the present study, we examined Kv4.3 channel expression on trigeminal neurons that innervate orofacial regions (V2 TG neurons) of rats using immunostaining method...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29310888/secondary-hyperparathyroidism-causing-increased-jaw-bone-density-and-mandibular-pain-a-case-report
#7
Thomas Aerden, Koenraad Grisar, Margaux Nys, Constantinus Politis
We present the case of a 32-year-old male patient complaining of recurrent mandibular pain for 3.5 years. Panoramic radiography indicated increased cortical density of the mandibular lower border. Scintigraphy and single-photon emission computed tomography revealed metabolic hyperactivity in that region without pathologic lymph nodes. A bone biopsy specimen of the mandibular lower border did not have inflammation or cytologic atypia. Endocrinologic investigation confirmed secondary hyperparathyroidism as a result of hypovitaminosis D...
December 7, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29284330/clinical-characterization-of-women-with-burning-mouth-syndrome-in-a-case-control-study
#8
Shikha Acharya, Anette Carlén, Bengt Wenneberg, Mats Jontell, Catharina Hägglin
OBJECTIVE: Burning mouth syndrome (BMS) is a chronic orofacial pain disorder that is defined by a burning sensation in the oral mucosa. The aim of this study was to investigate the underlying factors, clinical characteristics and self-reported oral and general health factors associated with BMS. MATERIAL AND METHODS: Fifty-six women with BMS (mean age: 67.7) and their age-matched controls were included in the study. A general questionnaire, an OHRQL index and BMS-specific questionnaires were used...
December 28, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29279685/psychological-factors-in-oral-mucosal-and-orofacial-pain-conditions
#9
REVIEW
Mohammad S Alrashdan, Mustafa Alkhader
The psychological aspects of chronic pain conditions represent a key component of the pain experience, and orofacial pain conditions are not an exception. In this review, we highlight how psychological factors affect some common oral mucosal and orofacial pain conditions (namely, oral lichen planus, recurrent aphthous stomatitis, burning mouth syndrome, and temporomandibular disorders) with emphasis on the significance of supplementing classical biomedical treatment modalities with appropriate psychological counseling to improve treatment outcomes in targeted patients...
October 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/29274162/low-level-laser-therapy-and-anesthetic-infiltration-for-orofacial-pain-in-patients-with-fibromyalgia-a-randomized-clinical-trial
#10
R-C-V de Souza, E de Sousa, K-O Scudine, U Meira, E de Oliveira E Silva, A Gomes, F-A Limeira-Junior
BACKGROUND: To compare the analgesic effect of anesthetic infiltration of lidocaine 2% and low-level laser therapy (LLLT) by GaAlAs into tender points of patients with orofacial pain and fibromyalgia (FM). MATERIAL AND METHODS: A randomized clinical trial was performed with adults (N=66) that were allocated into two groups (1:1): Group A received LLLT irradiation by Diode Laser GaAlAs (780nm) with expositions twice a week during six weeks and Group B was treated with anesthetic infiltration of lidocaine 2% without vasoconstrictor once a week for four weeks...
December 23, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29261544/mu-opioid-receptors-in-ganglia-but-not-in-muscle-mediate-peripheral-analgesia-in-rat-muscle-pain
#11
Ana Bagues, María Isabel Martín, Alejandro Higuera-Matas, Jesús Esteban-Hernández, Emilio Ambrosio, Eva María Sánchez-Robles
BACKGROUND: Previous studies have demonstrated the participation of peripheral μ-opioid receptors (MOR) in the antinociceptive effect of systemically administered morphine and loperamide in an orofacial muscle pain model, induced by hypertonic saline, but not in a spinally innervated one, in rats. In this study, we determine whether this peripheral antinociceptive effect is due to the activation of MOR localized in the muscle, ganglia, or both. METHODS: To determine the local antinociceptive effect of morphine and loperamide, 2 models of acute muscle pain (trigeminal and spinal) were used...
December 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29246259/macrophages-in-trigeminal-ganglion-contribute-to-ectopic-mechanical-hypersensitivity-following-inferior-alveolar-nerve-injury-in-rats
#12
Dulguun Batbold, Masamichi Shinoda, Kuniya Honda, Akihiko Furukawa, Momoko Koizumi, Ryuta Akasaka, Satoshi Yamaguchi, Koichi Iwata
BACKGROUND: Accidental mandibular nerve injury may occur during tooth extraction or implant procedures, causing ectopic orofacial pain. The exact mechanisms underlying ectopic orofacial pain following mandibular nerve injury is still unknown. Here, we investigated the role of macrophages and tumor necrosis factor alpha (TNFα) in the trigeminal ganglion (TG) in ectopic orofacial pain following inferior alveolar nerve transection (IANX). METHODS: IANX was performed and the mechanical head-withdrawal threshold (MHWT) in the whisker pad skin ipsilateral to IANX was measured for 15 days...
December 16, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29243716/oral-surgery-ii-part-5-chronic-orofacial-pain
#13
T Renton
Chronic orofacial pain syndromes represent a diagnostic challenge for any practitioner. Patients are frequently misdiagnosed or attribute their pain to a prior event such as a dental procedure, ENT problem or facial trauma. Psychiatric symptoms of depression and anxiety are prevalent in this population and compound the diagnostic conundrum. Treatment is less effective than in other pain syndromes and thus often requires a multidisciplinary approach to address the many facets of these conditions.
December 15, 2017: British Dental Journal
https://www.readbyqxmd.com/read/29209900/effect-of-testosterone-on-trpv1-expression-in-a-model-of-orofacial-myositis-pain-in-the-rat
#14
Xiaofeng Bai, Xia Zhang, Qing Zhou
Recent clinical studies have revealed sex differences in response to transient receptor potential vanilloid 1 (TRPV1) agonist-induced pain. However, the mechanism of these differences in TRPV1-related chronic pain remains unclear. In the present study, we investigate the effects of inflammation and gonadal hormones on TRPV1 expression in trigeminal ganglia. Inflammatory pain was modeled by injecting complete Freund's adjuvant (CFA) into the left masseter muscle in rats. TRPV1 mRNA and protein levels in the trigeminal ganglia of male and female rats following CFA injection were assessed...
December 5, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29202311/quantitative-sensory-response-of-the-scm-muscle-on-sustained-low-level-activation-simulating-co-contractions-during-bruxing
#15
Lydia Eberhard, Sophia Terebesi, Nikolaos Nikitas Giannakopoulos, Daniel Hellmann, Hans-Jürgen Schindler, Marc Schmitter, Doreen Pfau
OBJECTIVE: Bruxism is discussed as an etiological factor in the pathogenesis of orofacial and cervical pain. As the sternocleidomastoid muscle (SCM) is co-activated during clenching, our aim was to investigate, whether the muscle loading leads to peripheral or central sensitizations. DESIGN: In twenty-one healthy female volunteers, somatosensory profiles of the SCM were recorded according to the test battery of the German Research Network on Neuropathic Pain (DFNS) prior to and after an isometric muscle exercise...
November 10, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29201256/neuropeptides-and-atp-signaling-in-the-trigeminal-ganglion
#16
REVIEW
Tetsuya Goto, Haruki Iwai, Eriko Kuramoto, Atsushi Yamanaka
Peripheral nociceptive stimuli from orofacial structures are largely transmitted by the trigeminal nerve. According to the peripheral noxious stimuli, neurons in the trigeminal ganglion (TG) produce neuropeptides such as substance P, and calcitonin-gene-related peptide, etc. Beside the production of neuropeptides, there exists unique non-synaptic interaction system between maxillary and mandibular neurons in the TG. Neurons in the TG are surrounded by satellite glial cells (SGCs), which initially receive the signal from TG neurons...
November 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29197566/local-subcutaneous-injection-of-chlorogenic-acid-inhibits-the-nociceptive-trigeminal-spinal-nucleus-caudalis-neurons-in-rats
#17
Kaede Kakita, Hirona Tsubouchi, Mayu Adachi, Shiori Takehana, Yoshihito Shimazu, Mamoru Takeda
Acute administration of chlorogenic acid (CGA) in vitro was recently shown to modulate potassium channel conductance and acid-sensing ion channels (ASICs) in the primary sensory neurons; however, in vivo peripheral effects of CGA on the nociceptive mechanical stimulation of trigeminal neuronal activity remains to be determined. The present study investigated whether local administration of CGA in vivo attenuates mechanical stimulation-induced excitability of trigeminal spinal nucleus caudalis neuronal (SpVc) activity in rats...
November 29, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29197095/oro-facial-pain-and-temporomandibular-disorders-classification-systems-a-critical-appraisal-and-future-directions
#18
REVIEW
G D Klasser, D Manfredini, J-P Goulet, A De Laat
It is a difficult undertaking to design a classification system for any disease entity, let alone for oro-facial pain (OFP) and more specifically for temporomandibular disorders (TMD). A further complication of this task is that both physical and psychosocial variables must be included. To augment this process, a two-step systematic review, adhering to PRISMA guidelines, of the classification systems published during the last 20 years for OFP and TMD was performed. The first search step identified 190 potential citations which ultimately resulted in only 17 articles being included for in-depth analysis and review...
December 2, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29194773/plasma-il-8-signature-correlates-with-pain-and-depressive-symptomatology-in-patients-with-burning-mouth-syndrome-results-from-a-pilot-study
#19
Alison Barry, Ken D O'Halloran, Joseph P McKenna, Christine McCreary, Eric J Downer
BACKGROUND: Burning mouth syndrome (BMS) is a neuropathic orofacial pain condition of unknown aetiology that encompasses intra-oral burning pain without abnormal clinical findings. Psychological, neural and inflammatory processes are associated with BMS pathogenesis. Currently, studies characterising plasma cytokine/chemokine profiles with pain and depression in BMS patients are lacking. Considering that inflammation is associated with the pathophysiology of BMS, and that inflammation is closely associated with pain and depression, we aimed to correlate depressive symptomatology and oral cavity pain with plasma cytokine/chemokine signatures in a cohort of patients with BMS...
December 1, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29175957/brainstem-pain-control-circuitry-connectivity-in-chronic-neuropathic-pain
#20
E P Mills, F Di Pietro, Z Alshelh, C C Peck, G M Murray, E R Vickers, L A Henderson
Preclinical investigations have suggested that altered functioning of brainstem pain modulation circuits may be crucial for the maintenance of some chronic pain conditions. Whilst some human psychophysical studies show that patients with chronic pain display altered pain modulation efficacy, it remains unknown if brainstem pain modulation circuits are altered in individuals with chronic pain. The aim of the present investigation was to determine whether, in humans, chronic pain following nerve injury is associated with altered on-going functioning of the brainstem descending modulation systems...
November 23, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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