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Ventricular hypertrophy

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https://www.readbyqxmd.com/read/29227376/hypertensive-heart-disease-beyond-left-ventricular-hypertrophy-are-we-ready-for-echocardiographic-strain-evaluation-in-everyday-clinical-practice
#1
Marijana Tadic, Cesare Cuspidi, Michele Bombelli, Guido Grassi
: Hypertension-induced left ventricular (LV) remodeling is a well known entity that has usually been studied with traditional echocardiographic techniques. In the last decade echocardiographic methods are focused on evaluation of heart mechanics. The strain assessment is considered as part of comprehensive echocardiographic examination. Nevertheless, LV strain and particularly longitudinal strain was proofed as a significant independent predictor of cardiovascular and total morbidity and mortality, stronger than LV ejection fraction...
December 7, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29226693/higher-pulse-pressure-and-risk-for-cardiovascular-events-in-patients-with-essential-hypertension-the-campania-salute-network
#2
Costantino Mancusi, Maria A Losi, Raffaele Izzo, Grazia Canciello, Maria V Carlino, Giovanni Albano, Nicola De Luca, Bruno Trimarco, Giovanni de Simone
Background Increased pulse pressure is associated with structural target organ damage, especially in elderly patients, increasing cardiovascular risk. Design In this analysis, we investigated whether high pulse pressure retains a prognostic effect also when common markers of target organ damage are taken into account. Methods We analysed an unselected cohort of treated hypertensive patients from the Campania Salute Network registry ( n = 7336). Participants with available cardiac and carotid ultrasound were required to be free of prevalent cardiovascular disease, with ejection fraction ≥50%, and no more than stage III Chronic Kidney Disease...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29225188/rosuvastatin-improves-myocardial-hypertrophy-after-hemodynamic-pressure-overload-via-regulating-the-crosstalk-of-nrf2-are-and-tgf-%C3%AE-smads-pathways-in-rat-heart
#3
Pengbo Wang, Lin Luo, Qiusheng Shen, Gaoyong Shi, Anaz Mohammed, Songshi Ni, Xiang Wu
Left ventricular hypertrophy is more commonly associated with hemodynamic overload imposed by hypertension or volume overload. Transforming growth factor β (TGF-β) is involved in the cardiac hypertrophy and fibrosis of the left ventricle. The fact that TGF-β1 and the nuclear factor erythroid 2-related factor 2 (Nrf2) both become up-regulated upon persistent vessel overload suggests that these two factors may virtually impact on their signaling pathways. In this research, 40 rats were divided into sham group, model group, rosuvastatin low and high dose group...
December 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29223306/diagnostic-accuracy-of-multi-lead-ecgs-obtained-using-a-pocket-sized-bipolar-handheld-event-recorder
#4
Ani Nigolian, Nicolas Dayal, Haïg Nigolian, Carine Stettler, Haran Burri
BACKGROUND: Handheld ECG event recorders are useful for rhythm monitoring but only record a single lead, which may limit interpretation. We sought to investigate if a multi-lead ECG may be reconstituted using this device, and aimed to evaluate diagnostic accuracy. METHODS: A commercially-available handheld bipolar ECG event recorder was used to reconstruct a 9-lead ECG (leads I, II and III, V1-6). Tracings were analyzed independently by a cardiologist and a fellow...
November 21, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29218105/systemic-inflammation-is-associated-with-myocardial-fibrosis-diastolic-dysfunction-and-cardiac-hypertrophy-in-patients-with-hypertrophic-cardiomyopathy
#5
Lu Fang, Andris H Ellims, Anna L Beale, Andrew J Taylor, Andrew Murphy, Anthony M Dart
BACKGROUND: Regional or diffuse fibrosis is an early feature of hypertrophic cardiomyopathy (HCM) and is related to poor prognosis. Previous studies have documented low-grade inflammation in HCM. The aim of this study was to examine the relationships between circulating inflammatory markers and myocardial fibrosis, systolic and diastolic dysfunction, and the degree of cardiac hypertrophy in HCM patients. METHODS AND RESULTS: Fifty HCM patients were recruited while 20 healthy subjects served as the control group...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29217663/prevalence-and-clinical-characteristics-of-refractory-hypertension
#6
Pedro Armario, David A Calhoun, Anna Oliveras, Pedro Blanch, Ernest Vinyoles, Jose R Banegas, Manuel Gorostidi, Julián Segura, Luis M Ruilope, Tanja Dudenbostel, Alejandro de la Sierra
BACKGROUND: We aimed to estimate the prevalence of refractory hypertension (RfH) and to determine the clinical differences between these patients and resistant hypertensives (RH). Secondly, we assessed the prevalence of white-coat RfH and clinical differences between true- and white-coat RfH patients. METHODS AND RESULTS: The present analysis was conducted on the Spanish Ambulatory Blood Pressure Monitoring Registry database containing 70 997 treated hypertensive patients...
December 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29217433/hypertrophic-cardiomyopathy-linked-mutation-in-troponin-t-causes-myofibrillar-disarray-and-pro-arrhythmic-action-potential-changes-in-human-ipsc-cardiomyocytes
#7
Lili Wang, Kyungsoo Kim, Shan Parikh, Adrian Gabriel Cadar, Kevin R Bersell, Huan He, Jose R Pinto, Dmytro O Kryshtal, Bjorn C Knollmann
BACKGROUND: Mutations in cardiac troponin T (TnT) are linked to increased risk of ventricular arrhythmia and sudden death despite causing little to no cardiac hypertrophy. Studies in mice suggest that the hypertrophic cardiomyopathy (HCM)-associated TnT-I79N mutation increases myofilament Ca sensitivity and is arrhythmogenic, but whether findings from mice translate to human cardiomyocyte electrophysiology is not known. OBJECTIVES: To study the effects of the TnT-I79N mutation in human cardiomyocytes...
December 4, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29216197/shift-toward-greater-pathologic-post-myocardial-infarction-remodeling-with-loss-of-the-adaptive-hypertrophic-signaling-of-alpha1-adrenergic-receptors-in-mice
#8
Che-Chung Yeh, Yanying Fan, Yanchun Xu, Yi-Lin Yang, Paul C Simpson, Michael J Mann
RATIONALE: We have hypothesized that post-infarction cardiac remodeling can be influenced by shifts in the balance between intracellular mediators of "pathologic" and "physiologic" hypertrophy. Although alpha1 adrenergic receptors (alpha1-ARs) mediate pro-adaptive hypertrophy during pressure overload, little is known about their role or downstream mediators after myocardial infarction. METHODS: We performed loss-of-function experiments via coronary ligation in alpha1A-AR knockout (AKO) mice...
2017: PloS One
https://www.readbyqxmd.com/read/29215092/improvement-in-the-sensitivity-of-newborn-screening-for-fabry-disease-among-females-through-the-use-of-a-high-throughput-and-cost-effective-method-dna-mass-spectrometry
#9
Yung-Hsiu Lu, Po-Hsun Huang, Li-Yun Wang, Ting-Rong Hsu, Hsing-Yuan Li, Pi-Chang Lee, Yu-Ping Hsieh, Sheng-Che Hung, Yu-Chen Wang, Sheng-Kai Chang, Ya-Ting Lee, Ping-Hsun Ho, Hui-Chen Ho, Dau-Ming Niu
Many female carriers of Fabry disease are likely to develop severe morbidity and mortality. However, by our own estimation, around 80% of female newborns are missed by our current enzyme-based screening approach. Our team's aim was to develop an improved cost-effective screening method that is able to detect Fabry disease among female newborns. In Taiwan, based on a database of 916,000 newborns, ~98% of Fabry patients carry mutations out of a pool of only 21 pathogenic mutations. An Agena iPLEX platform was designed to detect these 21 pathogenic mutations using only a single-assay panel...
November 15, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/29212831/impaired-pulmonary-arterial-vasoconstriction-and-nitric-oxide-mediated-relaxation-underlie-severe-pulmonary-hypertension-in-sugen-hypoxia-rat-model
#10
Helen Christou, Hannes Hudalla, Zoe Michael, Evgenia Filatava, Jun Li, Minglin Zhu, Jose Possomato-Vieira, Carlos Dias-Junior, Stella Kourembanas, Raouf A Khalil
Pulmonary vasoreactivity could determine the responsiveness to vasodilators and in turn the prognosis of pulmonary hypertension (PH). We hypothesized that pulmonary vasoreactivity is impaired, and examined the underlying mechanisms, in the sugen-hypoxia rat model of severe PH. Male Sprague-Dawley rats were injected with sugen (20 mg/kg sc) and exposed to hypoxia (9% O2) for 3 weeks followed by 4 weeks in normoxia (Su/Hx), or treated with sugen alone (Su) or hypoxia alone (Hx) or neither (Nx). After hemodynamic measurements, the heart was assessed for right ventricular hypertrophy (Fulton's Index), the pulmonary artery, aorta and mesenteric arteries were isolated for vascular function studies, and contractile markers were measured in pulmonary artery using quantitative PCR...
December 6, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29212800/extracellular-retention-of-pdgf-b-directs-vascular-remodeling-in-mouse-hypoxia-induced-pulmonary-hypertension
#11
Philip Tannenberg, Ya-Ting Chang, Lars Muhl, Bàrbara Laviña, Hanna Gladh, Guillem Genové, Christer Betsholtz, Erika Folestad, Karin Tran-Lundmark
Pulmonary hypertension (PH) is a lethal condition and current vasodilator therapy has limited effect. Anti-proliferative strategies targeting platelet-derived growth factor (PDGF) receptors, such as imatinib, have generated promising results in animal studies. Imatinib is however a non-specific tyrosine kinase inhibitor and has in clinical studies caused unacceptable adverse events. Further studies are needed on the role of PDGF signaling in PH. Here, mice expressing a variant of PDGF-B with no retention motif (Pdgfbret/ret), resulting in defective binding to extracellular matrix, were studied...
December 6, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29209776/hyperoxia-induced-cardiotoxicity-and-ventricular-remodeling-in-type-ii-diabetes-mice
#12
Jennifer Leigh Rodgers, Eva Samal, Subhra Mohapatra, Siva Kumar Panguluri
Hyperoxia, or supplemental oxygen, is regularly used in the clinical setting for critically ill patients in ICU. However, several recent studies have demonstrated the negative impact of this treatment in patients in critical care, including increased rates of lung and cardiac injury, as well as increased mortality. The purpose of this study was to determine the predisposition for arrhythmias and electrical remodeling in a type 2 diabetic mouse model (db/db), as a result of hyperoxia treatment. For this, db/db and their heterozygous controls were treated with hyperoxia (> 90% oxygen) or normoxia (normal air) for 72-h...
December 5, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29207045/effect-of-atractylodes%C3%A2-macrocephala-rhizoma-on-isoproterenol%C3%A2-induced-ventricular-remodeling-in-rats
#13
Xiao-Hua Cui, Hui-Lin Wang, Rong Wu, Ping-An Yao, Ke-Zhao Wei, Jian-Ping Gao
Myocardial infarction (MI) is the primary cause of ventricular remodeling (VR). The aim of the present study was to determine the effect of Atractylodis macrocephalae rhizoma (AMR) on VR induced by isoproterenol (ISO) in rats. Male Sprague Dawley rats were randomly divided into the normal control, ISO‑induced and AMR groups. Rats in the ISO‑induced and AMR groups were subcutaneously injected with 85 mg/kg/day ISO for two consecutive days. Compared with the ISO‑induced group, AMR normalized the levels of hemodynamic parameters, markedly attenuated myocardial pathological damage, decreased the level of N‑terminal prohormone of brain natriuretic peptide, and inhibited cardiac hypertrophy and myocardial fibrosis...
November 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29205991/cardiac-deformation-imaging
#14
Minna Kylmälä
Deformation imaging (strain imaging) is an echocardiographic method for evaluating myocardial function that is also suitable for clinical use. There are two deformation imaging techniques: Tissue Doppler and 2D strain (speckle tracking). Deformation imaging allows the measurement of regional myocardial deformation in three dimensions. Longitudinal deformation (strain) measures longitudinal myocardial fiber contraction, and reflects subendocardial myocardial function, which is usually the first to deteriorate in patients with heart disease...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29205626/feasibility-and-reproducibility-of-feature-tracking-based-strain-and-strain-rate-measures-of-the-left-ventricle-in-different-diseases-and-genders
#15
Alicia M Maceira, Luis Tuset-Sanchis, Miguel López-Garrido, Marta San Andres, M Pilar López-Lereu, Jose V Monmeneu, M Pilar García-González, Laura Higueras
BACKGROUND: The measurement of myocardial deformation by strain analysis is an evolving tool to quantify regional and global myocardial function. PURPOSE: To assess the feasibility and reproducibility of myocardial strain/strain rate measurements with magnetic resonance feature tracking (MR-FT) in healthy subjects and in patient groups. STUDY TYPE: Prospective study. POPULATION: Sixty patients (20 hypertensives with left ventricular (LV) hypertrophy (H); 20 nonischemic dilated cardiomyopathy (D); 20 ischemic heart disease (I); as well as 20 controls (C) were included, 10 men and 10 women in each group...
December 4, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29204738/the-association-between-myocardial-fibrosis-and-depressed-capillary-density-in-rat-model-of-left-ventricular-hypertrophy
#16
Ying Xiao, Yinjie Liu, Jiaming Liu, Y James Kang
Myocardial fibrogenesis is initiated once the coordination between oxygen supply and demand is disrupted in pressure overload-induced cardiac hypertrophy. Clinical observations showed that myocardial fibrosis did not evenly occur in the hypertrophic myocardium. The present study was undertaken to specifically address differential vulnerabilities to fibrogenesis of different regions in the myocardium subjected to pressure overload-induced hypertrophy. SD rats were divided into two groups, sham-operated control and ascending artery constriction-induced cardiac hypotrophy...
December 4, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29204251/roles-and-mechanisms-of-herbal-medicine-for-diabetic-cardiomyopathy-current-status-and-perspective
#17
REVIEW
Jinfan Tian, Yingke Zhao, Yanfei Liu, Yue Liu, Keji Chen, Shuzheng Lyu
Diabetic cardiomyopathy is one of the major complications among patients with diabetes mellitus. Diabetic cardiomyopathy (DCM) is featured by left ventricular hypertrophy, myocardial fibrosis, and damaged left ventricular systolic and diastolic functions. The pathophysiological mechanisms include metabolic-altered substrate metabolism, dysfunction of microvascular, renin-angiotensin-aldosterone system (RAAS) activation, oxidative stress, cardiomyocyte apoptosis, mitochondrial dysfunction, and impaired Ca2+ handling...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29200951/the-clinical-usefulness-of-measurement-of-visceral-fat-area-using-multi-frequency-bioimpedance-the-association-with-cardiac-and-renal-function-in-general-population-with-relatively-normal-renal-function
#18
Hye Eun Yoon, Sang Su Choi, Yaeni Kim, Seok Joon Shin
Background: This study was performed to determine the clinical usefulness of measurement of visceral fat area (VFA) using bioimpedance analysis in relation with left ventricular hypertrophy (LVH), diastolic dysfunction parameters, and decreased estimated glomerular filtration rate (eGFR). Methods: A cross-sectional analysis was performed on 1028 patients with eGFR≥60 ml/min/1.73m2, aged 40 - 64 years, and who underwent routine health check-ups. Subjects were divided into tertiles based on their VFA. Associations of VFA with echocardiographic parameters and eGFR were evaluated...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29199265/standard-values-and-characteristics-of-electrocardiographic-findings-in-children-and-adolescents
#19
Masao Yoshinaga, Mari Iwamoto, Hitoshi Horigome, Naokata Sumitomo, Hiroya Ushinohama, Naomi Izumida, Nobuo Tauchi, Tatsuya Yoneyama, Katsumi Abe, Masami Nagashima
BACKGROUND: Reference values and the characteristics of the electrocardiographic (ECG) findings using a large number of subjects are lacking for children and adolescents.Methods and Results:A total of 56,753 digitally stored ECGs of participants in a school-based ECG screening system were obtained between 2006 and 2009 in Kagoshima, Japan. Each ECG was manually reviewed by 2 pediatric cardiologists and only ECGs with sinus rhythm were included. A final total of 48,401 ECGs from 16,773 1st (6 years old, 50% girls), 18,126 7th (12 years old, 51% girls), and 13,502 10th graders (15 years old, 52% girls) were selected...
December 1, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29198831/the-development-of-left-ventricular-hypertrophy-in-patients-with-left-sided-obstructive-lesions-are-genetics-at-play
#20
EDITORIAL
Melissa G Y Lee, Yves d'Udekem
No abstract text is available yet for this article.
January 2018: Heart, Lung & Circulation
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