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Transfusion Transmissible Infections

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https://www.readbyqxmd.com/read/29150323/screening-of-patient-blood-samples-for-babesiosis-using-enzymatic-assays
#1
Shekerah Primus, Lavoisier Akoolo, Samantha Schlachter, Nikhat Parveen
Human babesiosis is an emerging tick-borne disease in the United States and Europe. Transmitted by Ixodes ticks, the causative agent Babesia microti is an intraerythrocytic parasite that causes mild to deadly disease. Transmission of B. microti can also occur by transfusion of infected blood and blood products resulting in transfusion-transmitted babesiosis (TTB), which carries a high risk of fatality. To effectively manage this rise in B. microti infections, better screening tools are needed, which require minimal manipulation of the samples before testing...
November 12, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29097653/experimental-transfusion-of-variant-cjd-infected-blood-reveals-previously-uncharacterised-prion-disorder-in-mice-and-macaque
#2
Emmanuel E Comoy, Jacqueline Mikol, Nina Jaffré, Vincent Lebon, Etienne Levavasseur, Nathalie Streichenberger, Chryslain Sumian, Armand Perret-Liaudet, Marc Eloit, Olivier Andreoletti, Stéphane Haïk, Philippe Hantraye, Jean-Philippe Deslys
Exposure of human populations to bovine spongiform encephalopathy through contaminated food has resulted in <250 cases of variant Creutzfeldt-Jakob disease (vCJD). However, more than 99% of vCJD infections could have remained silent suggesting a long-term risk of secondary transmission particularly through blood. Here, we present experimental evidence that transfusion in mice and non-human primates of blood products from symptomatic and non-symptomatic infected donors induces not only vCJD, but also a different class of neurological impairments...
November 2, 2017: Nature Communications
https://www.readbyqxmd.com/read/29097105/emergent-predictors-of-hepatitis-c-infection-among-non-injection-drug-users
#3
Sheila Araújo Teles, Elucir Gir, Regina Maria Bringel Martins, Megmar Aparecida Dos Santos Carneiro, Marcos André de Matos, Karla Antonieta Amorim Caetano
BACKGROUND: Hepatitis C virus (HCV) presents a significant public health issue, especially among high-risk populations, such as truck drivers, prisoners, people living with HIV, people living with tuberculosis, and people who are homeless. METHODS: This cross-sectional study analyzed the data of 1600 individuals recruited from high-risk populations who denied the use of injection drugs and/or history of blood transfusion to better understand on epidemiology of HCV...
October 30, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29082905/the-cost-effectiveness-of-predonation-screening-for-transfusion-transmissible-infections-using-rapid-test-kits-in-a-hospital-based-blood-transfusion-centre
#4
Adedoyin Owolabi Dosunmu, Akinsegun Abduljaleel Akinbami, Ayobami Kamal Ismail, Modupe Adebimpe Olaiya, Ebele Ifeyinwa Uche, Igbinoba Kingsley Aile
OBJECTIVE: Blood transfusion practice emphasises safety, efficacy and appropriate use. These require cost-effective programme management. This study focused on the cost of screening for transfusion transmissible infections (TTI). METHODS: This was a 1 year (2016) analysis of screening in a hospital-based transfusion centre. The cost of screening all blood donors by ELISA was compared to the cost of serial screening starting from rapid kit, taking into account, the estimated cost of blood bags prevented from discard after ELISA screening (attributable cost)...
July 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29070083/human-immunodeficiency-virus-infection-acquired-through-a-traditional-healer-s-ritual-a-case-report
#5
Pedro Pallangyo, Paulina Nicholaus, Henry Mayala, Andrew Kabeho, Anna Nkinda, Mohamed Janabi
BACKGROUND: Globally, over 36 million people were infected with human immunodeficiency virus by the end of 2015. The Sub-Saharan African region home to less than one-fifth of the global population disproportionately harbors over two-thirds of the total infections and related deaths. Residents of Sub-Saharan Africa continue to face limited access to allopathic medicine and it is estimated that over 80% of primary health care needs in the region are met through traditional healing practices...
October 26, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29063378/epidemiology-of-hepatitis-b-in-pregnant-iranian-women-a-systematic-review-and-meta-analysis
#6
REVIEW
Gholamreza Badfar, Masoumeh Shohani, Marzieh Parizad Nasirkandy, Akram Mansouri, Ghobad Abangah, Shoboo Rahmati, Sanaz Aazami, Ali Soleymani, Milad Azami
Perinatal transmission is one of the most common routes of hepatitis B virus (HBV) transmission. This study aims to identify the epidemiological features of HBV among pregnant Iranian women. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Two authors independently searched several online databases without time limit until May 2017. The databases include Magiran, Iranmedex, SID, Medlib, IranDoc, Scopus, PubMed, Science Direct, Cochrane, Web of Science and Google Scholar...
October 23, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29052242/emerging-infectious-disease-outbreaks-estimating-disease-risk-in-australian-blood-donors-travelling-overseas
#7
A Coghlan, V C Hoad, C R Seed, R Lp Flower, R J Harley, D Herbert, H M Faddy
BACKGROUND AND OBJECTIVES: International travel assists spread of infectious pathogens. Australians regularly travel to South-eastern Asia and the isles of the South Pacific, where they may become infected with infectious agents, such as dengue (DENV), chikungunya (CHIKV) and Zika (ZIKV) viruses that pose a potential risk to transfusion safety. In Australia, donors are temporarily restricted from donating for fresh component manufacture following travel to many countries, including those in this study...
October 19, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29043965/japanese-encephalitis-virus-transmitted-via-blood-transfusion-hong-kong-china
#8
Vincent C C Cheng, Siddharth Sridhar, Shuk-Ching Wong, Sally C Y Wong, Jasper F W Chan, Cyril C Y Yip, Chi-Hung Chau, Timmy W K Au, Yu-Yan Hwang, Carol S W Yau, Janice Y C Lo, Cheuk-Kwong Lee, Kwok-Yung Yuen
Japanese encephalitis virus (JEV) is a mosquitoborne virus endemic to China and Southeast Asia that causes severe encephalitis in <1% of infected persons. Transmission of JEV via blood transfusion has not been reported. We report transmission of JEV via blood donation products from an asymptomatic viremic donor to 2 immunocompromised recipients. One recipient on high-dose immunosuppressive drugs received JEV-positive packed red blood cells after a double lung transplant; severe encephalitis and a poor clinical outcome resulted...
January 15, 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29036415/transfusion-transmissible-infections-among-walk-in-blood-donors-at-kisumu-regional-blood-transfusion-centre-kisumu-county-kenya-2015
#9
Dominic Wamamba, Dickens Onyango, Elvis Oyugi, Evalyne Kanyina, Mark Obonyo, Jane Githuku, James Ransom
Background: Transfusion transmissible infections (TTIs) are threats to blood safety. This study investigated TTIs among volunteer blood donors at the Kisumu Regional Blood Transfusion Centre (KRBTC) in Kenya. Methods: We performed a retrospective record review of blood donor registers at KRBTC, 2015. Walk-in donors accepted for donation were analyzed to determine prevalence of human immunodeficiency virus (HIV), hepatitis B (HBV), hepatitis C (HCV), and syphilis...
November 8, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/29032634/prevalence-of-hepatitis-c-infection-and-its-associated-factors-in-healthy-adults-without-identifiable-route-of-transmission
#10
Ngai Sze Wong, Cheuk Kwong Lee, Siu Cheung Ng, Hoi Kei Wong, Denise P C Chan, Shui Shan Lee
While hepatitis C virus (HCV) infection is long known to be associated with parenteral exposure, the specific route of transmission is not identified in a proportion of infected patients. Taking blood donors as the surrogate of healthy adults in the community in Hong Kong, we identified 91 HCV infected donors (≤0.02% positive rate) in 2014-2016, of whom 46 were recruited in a mixed method study to examine their transmission routes. A majority (75%) of the recruited donors were HCV RNA positive, with the predominant subtypes being 1b and 6a...
October 15, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28982042/evaluation-of-clinical-sensitivity-and-specificity-of-hepatitis-b-virus-hbv-hepatitis-c-virus-and-human-immunodeficiency-virus-1-by-cobas-mpx-detection-of-occult-hbv-infection-in-an-hbv-endemic-area
#11
Jihye Ha, Younhee Park, Hyon-Suk Kim
BACKGROUND: Transfusion-transmitted infectious diseases remain a major concern for blood safety, particularly with hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV). Nucleic acid testing (NAT) in donor screening shortens the serologically negative window period and reduces virus transmission. The cobas MPX (Roche Molecular Systems, Inc., Branchburg, New Jersey) is a recently developed multiplex qualitative PCR system that enables the simultaneous detection of HBV, HCV, and HIV with improved sensitivity and throughput using cobas 6800 and 8800 instruments...
September 21, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28970713/chronic-hepatitis-c-do-generics-work-as-well-as-branded-drugs
#12
REVIEW
Madhumita Premkumar, Gagandeep S Grover, Radha K Dhiman
India has a large share of the hepatitis C virus (HCV) burden of the world. Unsafe medical practices and blood transfusions are the leading modes of transmission of HCV in India. The commonest HCV genotype in India is genotype 3 followed by genotype 1. While directly acting antivirals (DAAs) agents have become available at reasonable rates in India, cost of therapy remains a major barrier for control of HCV in India. Generic DAAs have been proven to be cost-saving in prior studies. We examined data from various studies in India and elsewhere using generic DAAs, and evaluated whether they are equally efficacious as the branded drugs...
September 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28970700/use-of-smartphone-technology-for-managing-workload-in-transfusion-transmissible-infection-nucleic-acid-testing-laboratory-for-platelet-concentrate-inventory-management-resulting-in-timely-issue-of-platelets-experience-from-a-tertiary-care-center
#13
Rekha Hans, Suresh Sharma, Neelam Marwaha, Suchet Sachdev, Hari Krishan Dhawan, Ashish Jain, Ratti Ram Sharma
No abstract text is available yet for this article.
July 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28968013/detection-of-trypanosoma-cruzi-antibodies-in-multitransfused-patients-in-colombia
#14
Mauricio Beltrán, Andrea Herrera, Astrid Carolina Flórez, Maritza Berrio, María Isabel Bermúdez
INTRODUCTION: Chagas disease is a public health problem in Latin America. Even though vector-borne infection is the most important transmission mode for this disease, other modes such as transfusions require evaluation. OBJECTIVE: To describe the prevalence of T. cruzi infection in multitransfused patients. MATERIALS AND METHODS: We detected IgG antibodies against T. cruzi by two immunoassays in samples from multitransfused patients in four hospitals located in Bogotá and Medellín, Colombia...
September 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28966492/seroprevalence-of-transfusion-transmitted-infections-in-healthy-blood-donors-a-5-year-tertiary-care-hospital-experience
#15
Sushama A Chandekar, Gaythri P Amonkar, Heena M Desai, Nitin Valvi, Gururaj V Puranik
INTRODUCTION: Transfusion transmitted infections (TTIs) can cause threat to bloody safety as blood transfusion is an important mode of transmission of TTI to the recipient, hence, to prevent transmission of these diseases, screening tests on blood bags is an important step for blood safety. AIM: This study was undertaken with the aim of determining the seroprevalence of TTI in healthy blood donors in a tertiary care blood bank. MATERIALS AND METHODS: A retrospective study was carried out over a period of 5 years from January 2007 to December 2011...
October 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28965827/global-status-of-visceral-leishmanial-infection-among-blood-donors-a-systematic-review-and-meta-analysis
#16
REVIEW
Shabnam Asfaram, Mahdi Fakhar, Masoud Soosaraei, Saeed Hosseini Teshnizi, Ahmad Mardani, Elham Sadat Banimostafavi, Hajar Ziaei Hezarjaribi
INTRODUCTION: Transmission of Leishmania through transfusion has been reported from various Visceral leishmaniasis (VL) endemic areas of the world. The true burden of Leishmania infection in blood donors remains generally unknown. Thus, the present systematic review attempted to determine the global prevalence of Leishmania infection among blood donors. METHODS: Data were extracted through five English and five Persian databases during the period from 1997 to 2016...
September 21, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28960337/reconsideration-of-blood-donation-testing-strategy-for-human-t-cell-lymphotropic-virus-in-australia
#17
C E Styles, C R Seed, V C Hoad, S Gaudieri, A J Keller
BACKGROUND AND OBJECTIVES: Universal testing of blood donations for human T-cell lymphotropic virus (HTLV) in Australia may no longer be appropriate given the low prevalence of HTLV infection and the mitigating effect of universal leucodepletion for cellular components. This study aimed to determine the most appropriate HTLV testing strategy using the Risk-Based Decision-Making Framework for Blood Safety. MATERIALS AND METHODS: The risk of HTLV transfusion-transmission using three testing strategies (universal, new-donor and no testing) and cost-effectiveness of the first two strategies were assessed using adaptations of published mathematical models...
September 27, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28950254/genotype-distribution-and-molecular-epidemiology-of-hepatitis-c-virus-in-guangzhou-china-predominance-of-genotype-1b-and-increasing-incidence-of-genotype-6a
#18
Guosheng Yuan, Junwei Liu, Chengguang Hu, Huaping Huang, Minghua Qi, Tao Wu, Weifang Liang, Yi-Ping Li, Yong-Yuan Zhang, Yuanping Zhou
BACKGROUND/AIMS: Distribution of Hepatitis C virus (HCV) genotypes vary geographically and may associate with the mode of transmission. Little is known about the molecular epidemiology of HCV infection in Guangzhou, China. METHODS: A cross-sectional survey included 561 subjects with chronic HCV infection registered at Nanfang Hospital, Southern Medical University, was performed. All residents were invited for a questionnaire interview to collect information about their personal status and commercial blood donation history...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28942625/current-status-of-and-strategies-for-hepatitis-c-control-in-south-korea
#19
REVIEW
Beom Kyung Kim, Eun Sun Jang, Jeong Han Kim, Soo Young Park, Song Vogue Ahn, Hyung Joon Kim, Do Young Kim
Chronic hepatitis C (CHC) is caused by hepatitis C virus (HCV) infection. HCV infection causes acute hepatitis, and the majority of those infected progress to chronic hepatitis, and some of them develop cirrhosis and hepatocellular carcinoma. Transmission of HCV is parenteral, and the major transmission routes include drug abuse, insecure injections or medical procedures, contaminated syringes or needles, sexual contact with an HCV-infected person, vertical infection of newborns by infected mothers, the transfusion of blood or blood products contaminated with viruses, and organ transplants...
September 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28937073/hepatitis-c-virus-status-in-hemodialysis-patients-in-menoufia-government-egypt-five-years-apart-do-we-have-any-improvement
#20
Khaled Mohamed Amin Elzorkany, Ahmed Zahran
There is a high prevalence of hepatitis C virus (HCV) infection in hemodialysis (HD) patients in Menoufia Governorate, Egypt. The aim of this cross-sectional study was to assess current HCV status and its seroconversion in HD patients after implementing preventative measures to limit transmission of HCV. All data were compared with our previous data collected in 2011 before implementation of isolation policy. There was a significant decrease in HCV infection in HD patients from 49.6% in year 2011 to 41.9% in year 2016 (P = 0...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
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