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Transfusion Transmissible Infections

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https://www.readbyqxmd.com/read/29350414/ross-river-virus-in-australian-blood-donors-possible-implications-for-blood-transfusion-safety
#1
Helen M Faddy, Thu V Tran, Veronica C Hoad, Clive R Seed, Elvina Viennet, Hiu-Tat Chan, Robert Harley, Elise Hewlett, Roy A Hall, Helle Bielefeldt-Ohmann, Robert L P Flower, Natalie A Prow
BACKGROUND: Emerging transfusion-transmissible pathogens, including arboviruses such as West Nile, Zika, dengue, and Ross River viruses, are potential threats to transfusion safety. The most prevalent arbovirus in humans in Australia is Ross River virus (RRV); however, prevalence varies substantially around the country. Modeling estimated a yearly risk of 8 to 11 potentially RRV-viremic fresh blood components nationwide. This study aimed to measure the occurrence of RRV viremia among donors who donated at Australian collection centers located in areas with significant RRV transmission during one peak season...
January 19, 2018: Transfusion
https://www.readbyqxmd.com/read/29344018/three-year-experience-in-nat-screening-of-blood-donors-for-transfusion-transmitted-viruses-in-croatia
#2
Hana Safic Stanic, Ivana Babic, Margareta Maslovic, Vesna Dogic, Jasna Bingulac-Popovic, Manuela Miletic, Nina Jurakovic-Loncar, Tomislav Vuk, Maja Strauss-Patko, Irena Jukic
Background: Croatia implemented individual donation (ID)-NAT testing of blood donors in 2013 for three viruses HBV, HCV, and HIV-1 as a mandatory test for all blood donors. This study assessed the impact of NAT screening 3 years after its implementation. Methods: A total of 545,463 donations were collected and screened for HBV, HCV, and HIV-1 using the Procleix Ultrio Plus Assay. All initially reactive (IR) NAT samples were retested in triplicate and, if repeatedly reactive (RR), NAT discriminatory assay (dNAT) was performed...
November 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29288577/confirmatory-molecular-method-for-htlv-1-2-infection-in-high-risk-pregnant-women
#3
Ana Cristina Matheus Medeiros, Luine Rosele Renaud Vidal, Renate von Linsingen, Aline Naiara Ferin, Talita Bessani Strapasson, Sergio Monteiro de Almeida, Sonia Mara Raboni, Newton Sérgio de Carvalho, Meri Bordignon Nogueira
Human T-cell lymphotropic virus types 1/2 (HTLV-1/2) are transmitted through sexual intercourse, transfusion of blood components and vertical transmission, predominantly through breastfeeding. Six hundred forty-three pregnant women from a high-risk prenatal care unit at a general hospital were tested by serological tests using chemiluminescence (CMIA) for screening, followed by a molecular confirmatory test. Four patients (0.6%) tested positive for HTLV-1/2 by CMIA, two samples (0.3%) for each patient were confirmed as having HTLV-1 or HTLV-2 by PCR...
December 30, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29282809/serious-hazards-of-transfusion-conference-report-celebration-of-20-years-of-uk-haemovigilance
#4
P H B Bolton-Maggs
The Annual SHOT Report for incidents in 2016 was published on July 12 and celebrated of 20 years of UK haemovigilance. Components are very safe, related in part to risk-reduction measures triggered by SHOT reporting. Transfusion-related acute lung injury is now very rare (all plasma components are provided from male donors), and infection transmission is also uncommon - a single transmission of hepatitis E in 2016 and no bacterial transmissions. Human factors (errors) account for 87% of all reports. Deaths and major morbidity most often result from transfusion-associated circulatory overload...
December 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/29277955/tick-borne-illness-after-transplantation-case-and-review
#5
Tresa Reena Mascarenhas, Randi S Silibovsky, Pooja Singh, Katherine Belden
Tick-borne infections in solid organ transplant recipients are an infrequent and difficult diagnostic challenge owing to multiple routes of acquisition and unusual presentations. A 67-year-old male recipient of a combined liver and kidney transplant presented with recurrent fevers following surgery. Standard microbiologic workup was non-diagnostic. Shortness of breath, confusion, lethargy, and hypotension developed along with progressive anemia, requiring multiple blood transfusions. Workup suggested hemolysis and review of the peripheral smear was diagnostic for Babesia microti infection...
December 26, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29260743/-impact-of-current-approaches-to-laboratory-screening-of-donated-blood-and-its-components-on-hepatitis-b-virus-infection-in-patients-with-blood-system-diseases
#6
E N Ignatova, T A Tupoleva, E N Ovchinnikova, T Yu Romanova, N G Yaroslavtseva, F P Filatov, V V Troitskaya, L A Kuzmina, E N Parovichnikova, T V Gaponova, V G Savchenko
AIM: To evaluate the detection rate of markers for hepatitis B virus (HBV) in the blood samples taken from patients with blood system diseases, by applying the current approaches to examining donated blood and its components for markers of viral infections. MATERIAL AND METHODS: The investigation included blood samples from patients with blood system diseases (n=364) and donors (n=5,011). The results of laboratory screening of donated blood samples (n=13,081) were retrospectively analyzed...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29251601/walking-blood-banks-an-immediate-solution-to-rural-india-s-blood-drought
#7
Rachita Sood, Nakul Raykar, Brian Till, Hemant Shah, Nobhojit Roy
The current system of blood banks in India is such that rural patients are deprived of timely access to an adequate volume of life-saving blood, adding to preventable mortality. On the basis of an academic framework for a blood transfusion system, we describe an alternative approach in which rural practitioners utilise unbanked blood transfusions from a voluntary pool of pre-screened donors. This system would provide safe blood - as evidenced by international experience and limited projected increase in transfusion-transmissible infection in India - at a fraction of the financial cost imposed by the current system...
November 23, 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/29244001/transmissibility-of-intra-host-hepatitis-c-virus-variants
#8
David S Campo, June Zhang, Sumathi Ramachandran, Yury Khudyakov
BACKGROUND: Intra-host hepatitis C virus (HCV) populations are genetically heterogeneous and organized in subpopulations. With the exception of blood transfusions, transmission of HCV occurs via a small number of genetic variants, the effect of which is frequently described as a bottleneck. Stochasticity of transmission associated with the bottleneck is usually used to explain genetic differences among HCV populations identified in the source and recipient cases, which may be further exacerbated by intra-host HCV evolution and differential biological capacity of HCV variants to successfully establish a population in a new host...
December 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29239484/inactivation-of-middle-east-respiratory-syndrome-coronavirus-in-human-plasma-using-amotosalen-and-ultraviolet-a-light
#9
Salwa I Hindawi, Anwar M Hashem, Ghazi A Damanhouri, Sherif A El-Kafrawy, Ahmed M Tolah, Ahmed M Hassan, Esam I Azhar
BACKGROUND: Middle East respiratory syndrome-coronavirus (MERS-CoV) is a novel zoonotic pathogen. Although the potential for MERS-CoV transmission through blood transfusion is not clear, MERS-CoV was recognized as a pathogen of concern for the safety of the blood supply especially after its detection in whole blood, serum, and plasma of infected individuals. Here we investigated the efficacy of amotosalen and ultraviolet A light (UVA) to inactivate MERS-CoV in fresh-frozen plasma (FFP)...
December 14, 2017: Transfusion
https://www.readbyqxmd.com/read/29228016/prevalence-and-molecular-profiling-of-epstein-barr-virus-ebv-among-healthy-blood-donors-from-different-nationalities-in-qatar
#10
Maria K Smatti, Hadi M Yassine, Raed AbuOdeh, Asmaa AlMarawani, Sara A Taleb, Asmaa A Althani, Gheyath K Nasrallah
BACKGROUND: The Epstein-Barr virus (EBV) is the causative agent of infectious mononucleosis. EBV is highly prevalent lymphotropic herpesvirus and has been linked to several malignancies. Transmission is generally by oral secretions, but can be through blood transfusions and organ transplantations. This study aimed to determine the seroprevalence, viremia rates, and circulating genotypes of EBV in healthy blood donors in Qatar. METHODS: Blood samples from 673 blood donors of different nationalities residing in Qatar (mainly Qatar, Egypt, Syria, Jordan, Pakistan, and India) were collected and tested for anti-EBV capsid (VCA; IgG & IgM), nuclear (EBNA; IgG), and early (EA-D; IgG) antigens...
2017: PloS One
https://www.readbyqxmd.com/read/29194668/is-an-endoscopic-examination-associated-with-transfusion-transmissible-infections-a-systematic-review-and-meta-analysis
#11
REVIEW
Hans Van Remoortel, Vere Borra, Emmy De Buck, Veerle Compernolle, Philippe Vandekerckhove
BACKGROUND: The purpose of a donor medical questionnaire is to identify the blood donor's history relative to the current known blood-safety risks. A temporary deferral from blood donation after an endoscopic examination is enforced because of the reusable nature of the endoscope and close contact with the inner body. The objective of this systematic review was to find the best available evidence on the association between an endoscopic examination and the risk of transfusion-transmissible infections...
November 30, 2017: Transfusion
https://www.readbyqxmd.com/read/29192575/-current-dilemmas-on-the-transmission-of-hepatitis-e-virus
#12
E de Weerd-de Jong, A M Peters, J C Rahamat-Langendoen, N M A Blijlevens
Immunocompromised patients are especially at risk for developing chronic hepatitis E virus (HEV) infection, which may result in progressive liver disease and cirrhosis. In addition, treatment of chronic HEV infection in these patients often includes dose reduction of immunosuppressive therapy and this may lead to severe flare-ups of the underlying condition or even rejection of transplant material. Therefore prevention of HEV transmission is being more and more recognised as an essential step to stop increasing HEV seroprevalence...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29176851/economics-of-one-health-costs-and-benefits-of-integrated-west-nile-virus-surveillance-in-emilia-romagna
#13
Giulia Paternoster, Sara Babo Martins, Andrea Mattivi, Roberto Cagarelli, Paola Angelini, Romeo Bellini, Annalisa Santi, Giorgio Galletti, Simonetta Pupella, Giuseppe Marano, Francesco Copello, Jonathan Rushton, Katharina D C Stärk, Marco Tamba
Since 2013 in Emilia-Romagna, Italy, surveillance information generated in the public health and in the animal health sectors has been shared and used to guide public health interventions to mitigate the risk of West Nile virus (WNV) transmission via blood transfusion. The objective of the current study was to identify and estimate the costs and benefits associated with this One Health surveillance approach, and to compare it to an approach that does not integrate animal health information in blood donations safety policy (uni-sectoral scenario)...
2017: PloS One
https://www.readbyqxmd.com/read/29150323/screening-of-patient-blood-samples-for-babesiosis-using-enzymatic-assays
#14
Shekerah Primus, Lavoisier Akoolo, Samantha Schlachter, Nikhat Parveen
Human babesiosis is an emerging tick-borne disease in the United States and Europe. Transmitted by Ixodes ticks, the causative agent Babesia microti is an intraerythrocytic parasite that causes mild to deadly disease. Transmission of B. microti can also occur by transfusion of infected blood and blood products resulting in transfusion-transmitted babesiosis (TTB), which carries a high risk of fatality. To effectively manage this rise in B. microti infections, better screening tools are needed, which require minimal manipulation of the samples before testing...
November 12, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29097653/experimental-transfusion-of-variant-cjd-infected-blood-reveals-previously-uncharacterised-prion-disorder-in-mice-and-macaque
#15
Emmanuel E Comoy, Jacqueline Mikol, Nina Jaffré, Vincent Lebon, Etienne Levavasseur, Nathalie Streichenberger, Chryslain Sumian, Armand Perret-Liaudet, Marc Eloit, Olivier Andreoletti, Stéphane Haïk, Philippe Hantraye, Jean-Philippe Deslys
Exposure of human populations to bovine spongiform encephalopathy through contaminated food has resulted in <250 cases of variant Creutzfeldt-Jakob disease (vCJD). However, more than 99% of vCJD infections could have remained silent suggesting a long-term risk of secondary transmission particularly through blood. Here, we present experimental evidence that transfusion in mice and non-human primates of blood products from symptomatic and non-symptomatic infected donors induces not only vCJD, but also a different class of neurological impairments...
November 2, 2017: Nature Communications
https://www.readbyqxmd.com/read/29097105/emergent-predictors-of-hepatitis-c-infection-among-non-injection-drug-users
#16
Sheila Araújo Teles, Elucir Gir, Regina Maria Bringel Martins, Megmar Aparecida Dos Santos Carneiro, Marcos André de Matos, Karla Antonieta Amorim Caetano
BACKGROUND: Hepatitis C virus (HCV) presents a significant public health issue, especially among high-risk populations, such as truck drivers, prisoners, people living with HIV, people living with tuberculosis, and people who are homeless. METHODS: This cross-sectional study analyzed the data of 1600 individuals recruited from high-risk populations who denied the use of injection drugs and/or history of blood transfusion to better understand on epidemiology of HCV...
October 30, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29082905/the-cost-effectiveness-of-predonation-screening-for-transfusion-transmissible-infections-using-rapid-test-kits-in-a-hospital-based-blood-transfusion-centre
#17
Adedoyin Owolabi Dosunmu, Akinsegun Abduljaleel Akinbami, Ayobami Kamal Ismail, Modupe Adebimpe Olaiya, Ebele Ifeyinwa Uche, Igbinoba Kingsley Aile
OBJECTIVE: Blood transfusion practice emphasises safety, efficacy and appropriate use. These require cost-effective programme management. This study focused on the cost of screening for transfusion transmissible infections (TTI). METHODS: This was a 1 year (2016) analysis of screening in a hospital-based transfusion centre. The cost of screening all blood donors by ELISA was compared to the cost of serial screening starting from rapid kit, taking into account, the estimated cost of blood bags prevented from discard after ELISA screening (attributable cost)...
July 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29070083/human-immunodeficiency-virus-infection-acquired-through-a-traditional-healer-s-ritual-a-case-report
#18
Pedro Pallangyo, Paulina Nicholaus, Henry Mayala, Andrew Kabeho, Anna Nkinda, Mohamed Janabi
BACKGROUND: Globally, over 36 million people were infected with human immunodeficiency virus by the end of 2015. The Sub-Saharan African region home to less than one-fifth of the global population disproportionately harbors over two-thirds of the total infections and related deaths. Residents of Sub-Saharan Africa continue to face limited access to allopathic medicine and it is estimated that over 80% of primary health care needs in the region are met through traditional healing practices...
October 26, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29063378/epidemiology-of-hepatitis-b-in-pregnant-iranian-women-a-systematic-review-and-meta-analysis
#19
REVIEW
Gholamreza Badfar, Masoumeh Shohani, Marzieh Parizad Nasirkandy, Akram Mansouri, Ghobad Abangah, Shoboo Rahmati, Sanaz Aazami, Ali Soleymani, Milad Azami
Perinatal transmission is one of the most common routes of hepatitis B virus (HBV) transmission. This study aims to identify the epidemiological features of HBV among pregnant Iranian women. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Two authors independently searched several online databases without time limit until May 2017. The databases include Magiran, Iranmedex, SID, Medlib, IranDoc, Scopus, PubMed, Science Direct, Cochrane, Web of Science and Google Scholar...
October 23, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29052242/emerging-infectious-disease-outbreaks-estimating-disease-risk-in-australian-blood-donors-travelling-overseas
#20
A Coghlan, V C Hoad, C R Seed, R Lp Flower, R J Harley, D Herbert, H M Faddy
BACKGROUND AND OBJECTIVES: International travel assists spread of infectious pathogens. Australians regularly travel to South-eastern Asia and the isles of the South Pacific, where they may become infected with infectious agents, such as dengue (DENV), chikungunya (CHIKV) and Zika (ZIKV) viruses that pose a potential risk to transfusion safety. In Australia, donors are temporarily restricted from donating for fresh component manufacture following travel to many countries, including those in this study...
October 19, 2017: Vox Sanguinis
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