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Transfusion Transmissible Infections

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https://www.readbyqxmd.com/read/28644910/across-state-lines-fulminant-babesia-microti-infection-in-a-liver-transplant-recipient
#1
Eric G Meissner, John W McGillicuddy, Jerry Squires, Daniel Skipper, Sally Self, Dan Wray, Erin D Moritz, Susan L Stramer, Satish Nadig
The potential for transmission of Babesia microti by blood transfusion is well recognized. Physicians may be unaware that products used for transfusion may be collected from geographically diverse regions. We describe a liver transplant recipient in South Carolina who likely acquired B. microti infection from a unit of blood collected in Minnesota. This article is protected by copyright. All rights reserved.
June 23, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28643867/transfusion-transmitted-cmv-infection%C3%A2-%C3%A2-current-knowledge-and-future-perspectives
#2
REVIEW
M Ziemann, T Thiele
Transmission of human cytomegalovirus (CMV) via transfusion (TT-CMV) may still occur and remains a challenge in the treatment of immunocompromised CMV-seronegative patients, e.g. after stem cell transplantation, and for low birthweight infants. Measures to reduce the risk of TT-CMV have been evaluated in clinical studies, including leucocyte depletion of cellular blood products and/or the selection of CMV-IgG-negative donations. Studies in large blood donor cohorts indicate that donations from newly CMV-IgG-positive donors should bear the highest risk for transmitting CMV infections because they contain the highest levels of CMV-DNA, and early CMV antibodies cannot neutralise CMV...
June 23, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28633955/the-microbiome-and-transfusion-in-cancer-patients
#3
REVIEW
Hadi Goubran, Jerard Seghatchian, Julia Radosevic, Gaafar Ragab, Thierry Burnouf
Our microbiota is determined by many variables including ABO blood groups. The microbiota is not only confined to the gut and skin but is also recoverable from blood of healthy donors. The microbiota shape our immune system through cross reactivity with antigens, the expression of direct molecular patterns, the release of cytokines, the effects on nutrients and micronutrients and even through an interplay with epigenetics. It is likely, therefore, that a donor's microbiota could alter the antigenicity of blood and its components and potentially contribute to transfusion-related immune modulation [TRIM]...
June 3, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28599678/the-prevalence-of-dengue-virus-serotypes-in-asymptomatic-blood-donors-reveals-the-emergence-of-serotype-4-in-saudi-arabia
#4
Ahmed Mohamed Ashshi
BACKGROUND: Transmission of dengue virus (DENV) through blood transfusion has been documented and hence screening for DENV during blood donation has been recently recommended by the American Association of Blood Banks and Centres of Disease Control and Prevention. DENV is endemic in the Western province of the Kingdom of Saudi Arabia (KSA) and serotypes 1, 2 and 3, but not 4, have been detected. However, little is known regarding the rates of DENV during blood donation in the kingdom...
June 9, 2017: Virology Journal
https://www.readbyqxmd.com/read/28591470/cost-projections-for-implementation-of-safety-interventions-to-prevent-transfusion-transmitted-zika-virus-infection-in-the-united-states
#5
Katherine D Ellingson, Mathew R P Sapiano, Kathryn A Haass, Alexandra A Savinkina, Misha L Baker, Richard A Henry, James J Berger, Matthew J Kuehnert, Sridhar V Basavaraju
BACKGROUND: In August 2016, the Food and Drug Administration advised US blood centers to screen all whole blood and apheresis donations for Zika virus (ZIKV) with an individual-donor nucleic acid test (ID-NAT) or to use approved pathogen reduction technology (PRT). The cost of implementing this guidance nationally has not been assessed. STUDY DESIGN AND METHODS: Scenarios were constructed to characterize approaches to ZIKV screening, including universal ID-NAT, risk-based seasonal allowance of minipool (MP) NAT by state, and universal MP-NAT...
June 2017: Transfusion
https://www.readbyqxmd.com/read/28589643/residual-risk-of-transmission-of-human-immunodeficiency-virus-and-hepatitis-c-virus-infections-by-blood-transfusion-in-northern-brazil
#6
Priscilla Cristina Moura Vieira, Letícia Martins Lamarão, Carlos Eduardo de Melo Amaral, Angelita Silva de Miranda Corrêa, Maria Salete Maciel de Lima, Katarine Antônia Dos Santos Barile, Karine Lisboa Damasceno de Almeida, Vinicius de Albuquerque Sortica, André Salim Kayath, Rommel Mario Rodríguez Burbano
BACKGROUND: Nucleic acid test (NAT) blood screening for human immunodeficiency virus (HIV) and hepatitis C virus (HCV) was introduced in northern Brazil in July 2012. There are several Brazilian articles that have evaluated transfusion transmission risks for HIV and HCV. However, to our knowledge, this article is the first to evaluate the impact of HIV and HCV NAT implementation for blood screening in northern Brazil. The aim of this study was to determine the prevalence and incidence rates of HIV and HCV among blood donors and to compare the residual risk of transfusion transmission of these infections, before (2009-2011) and after (2012-2014) NAT implementation...
June 7, 2017: Transfusion
https://www.readbyqxmd.com/read/28573509/temporal-changes-in-the-modes-of-hepatitis-c-virus-transmission-in-the-usa-and-northern-china
#7
Elizabeth Wu, Ming Yang, Huiying Rao, Sherry Fu, Bo Feng, Ran Fei, Andy Lin, Robert J Fontana, Lai Wei, Anna S Lok
BACKGROUND: Predominant modes of hepatitis C virus (HCV) transmission vary between countries and over time. AIMS: To compare HCV transmission modes in the USA and northern China. METHODS: We conducted a prospective study enrolling two cohorts of chronic HCV patients in the USA, and in China at Beijing, and at Gu'an and Kuancheng counties in Hebei. Patients self-reported the most likely source and year of infection. RESULTS: A total of 1957 patients were studied (1000 USA; 957 China-428 Beijing, 387 Gu'an, 142 Kuancheng)...
June 1, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28571144/seroprevalence-and-trends-of-transfusion-transmissible-infections-in-blood-donors-in-andaman-and-nicobar-islands-an-institutional-retrospective-study
#8
Sahil Sehgal, P S Shaiji, Rupinder Kaur Brar
INTRODUCTION: Transfusion Transmissible Infections (TTIs) such as Human Immunodeficiency Virus (HIV), Hepatitis B virus (HBV), Hepatitis C Virus (HCV) and syphilis pose a threat to blood safety in a developing country like India. AIM: To determine the prevalence of TTIs among healthy donors in Andaman and Nicobar Islands, India, and to further help in determination of the population subset to be focused on for enhancing blood donor pool. MATERIALS AND METHODS: This retrospective cross-sectional study was conducted on all voluntary and replacement donors in a tertiary health care centre in Andaman and Nicobar Islands for a period of three years...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28567493/epidemiologic-features-of-348-children-with-hepatitis-c-virus-infection-over-a-30-year-period-a-nationwide-survey-in-japan
#9
Tatsuki Mizuochi, Tomoko Takano, Tadahiro Yanagi, Kosuke Ushijima, Mitsuyoshi Suzuki, Yoko Miyoshi, Yoshinori Ito, Ayano Inui, Hitoshi Tajiri
BACKGROUND: Although the epidemiology of hepatitis C virus (HCV) infection among children may be rapidly changing, few reports have characterized large nationwide cohorts of children with HCV infection. We, therefore, sought to clarify the epidemiology and natural history of HCV infection in Japanese children born over the last three decades. METHODS: Sixty-five pediatric centers retrospectively and prospectively recruited consecutive, otherwise-healthy HCV-infected children born during 1986 to 2015...
May 31, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28566073/emerging-infectious-disease-agents-and-blood-safety-in-australia-spotlight-on-zika-virus
#10
Philip Kiely, Erica M Wood, Manoj Gambhir, Allen C Cheng, Zoe K McQuilten, Clive R Seed
Emerging infectious diseases (EIDs) are infectious diseases whose incidence has increased in humans in the past 20 years or could increase in the near future. EID agents may represent a threat to blood safety if they infect humans, cause a clinically significant illness, include an asymptomatic blood phase in the course of infection, and are transmissible by transfusion. EID agents are typically not well characterised, but there is a consensus that we can expect ongoing outbreaks. Strategies to manage the risk to blood safety from EIDs include ongoing surveillance, regular risk assessments, modelling transfusion transmission risk, and deferral of donors with a recent travel history to outbreak areas...
June 5, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28547759/blood-donors-attitudes-towards-voluntary-non-remunerated-donation-in-trinidad-and-tobago
#11
K S Charles, A Poon King, A Ramai, K Rajnath, D Ramkissoon, S Ramkissoon, C Ramlal, K Ramnarine, K Rampersad, G Legall, S Pooransingh, A D Chantry
OBJECTIVES: To assess the attitude towards voluntary non-remunerated blood donation among blood donors in Trinidad and Tobago (TRT). BACKGROUND: Blood donors in TRT are either family replacement (F/R, 87%) or remunerated (13%). There is chronic blood shortage and high seroreactivity for transfusion-transmissible infections (TTI) in donors. Converting existing to voluntary non-remunerated donors (VNRD) reduces the need to recruit news donors in achieving 100% VNRD...
May 26, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28525510/zika-virus-obstetric-and-pediatric-anesthesia-considerations
#12
Jacqueline L Tutiven, Benjamin T Pruden, James S Banks, Mario Stevenson, David J Birnbach
As of November 2016, the Florida Department of Health (FDH) and the Centers for Disease Control and Prevention have confirmed more than 4000 travel-related Zika virus (ZIKV) infections in the United States with >700 of those in Florida. There have been 139 cases of locally acquired infection, all occurring in Miami, Florida. Within the US territories (eg, Puerto Rico, US Virgin Islands), >30,000 cases of ZIKV infection have been reported. The projected number of individuals at risk for ZIKV infection in the Caribbean and Latin America approximates 5 million...
June 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28523053/seroprevalence-of-transfusion-transmitted-infections-among-different-blood-group-donors-at-blood-bank-lumhs-hyderabad
#13
Faheem Ahmed Memon, Ikram Din Ujjan, Amir Iqbal Memon, Abdul Rehman Shaikh, Ali Raza Rao, Arshi Naz
OBJECTIVES: To study the prevalence of HBsAg, Anti-HCV, HIV, Syphilis and Malaria in blood donors. METHODS: This is a cross sectional descriptive study, conducted at Blood bank and Transfusion center at Liaquat University of Medical & Health Sciences (LUMHS) Hyderabad, during the period from January, 2014 to June, 2015. A total of 4683 blood donors were screened for HBsAg, Anti-HCV and HIV on Architect 20001 (manufactured by Abbott), employing chemiluminescent microparticle immunoassay (CMIA)...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28502333/zika-virus-epidemiology-pathogenesis-and-human-disease
#14
REVIEW
Elizabeth K Nugent, Anne K Nugent, Rebecca Nugent, Kenneth Nugent
The Zika virus is a positive sense, single-stranded RNA arbovirus in the Flaviviridae family, genus Flavivirus. This virus was initially isolated in Africa and is transmitted to nonhuman primates and humans by mosquitoes. Initial reports describe sporadic mild viral infection with fever, arthralgia, myalgia and conjunctivitis in Africa and Asia. However, its geographic distribution has significantly increased, and it has caused large outbreaks in the Yap Islands in 2007, in French Polynesia in 2013 and in Brazil in 2015...
May 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28488974/blood-donor-deferral-policies-across-europe-and-characteristics-of-men-who-have-sex-with-men-screened-for-human-immunodeficiency-virus-in-blood-establishments-data-from-the-european-men-who-have-sex-with-men-internet-survey-emis
#15
Susanne B Schink, Ruth Offergeld, Axel J Schmidt, Ulrich Marcus
BACKGROUND: The predominant mode of transmission of human immunodeficiency virus (HIV) in Europe is male-to-male transmission. Men who have sex with men (MSM) are deferred from donating blood in many countries, but nevertheless do donate blood. Based on data from 34 countries, we estimated the proportion of MSM screened for HIV in the context of a blood donation and identified individual factors associated with this HIV screening in order to propose possible public health interventions...
March 23, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28488960/towards-pathogen-inactivation-of-red-blood-cells-and-whole-blood-targeting-viral-dna-rna-design-technologies-and-future-prospects-for-developing-countries
#16
REVIEW
Victor J Drew, Lassina Barro, Jerard Seghatchian, Thierry Burnouf
Over 110 million units of blood are collected yearly. The need for blood products is greater in developing countries, but so is the risk of contracting a transfusion-transmitted infection. Without efficient donor screening/viral testing and validated pathogen inactivation technology, the risk of transfusion-transmitted infections correlates with the infection rate of the donor population. The World Health Organization has published guidelines on good manufacturing practices in an effort to ensure a strong global standard of transfusion and blood product safety...
April 13, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28483726/prevalence-of-igg-and-igm-anti-toxoplasma-gondii-antibodies-in-blood-donors-at-urmia-blood-transfusion-organization-iran
#17
Khosrow Hazrati Tappeh, Jalil Musavi, Mohammad Baradaran Safa, Hosein Galavani, Hamid Alizadeh
OBJECTIVE: The importance of toxoplasmosis lies in its global spread, opportunistic nature, and causative role in abortion or irreparable adverse effects on infants of infected pregnant women. Toxoplasma gondii has different transmission routes to humans, including blood transfusion. The objective of the present study was to evaluate the prevalence of IgG and IgM antibodies specific for T. gondii in blood donors at the Urmia Blood Transfusion Organization in west Azerbaijan, Iran. METHODS: The present analytical, descriptive study evaluated the plasma of 270 randomly selected blood bags donated in 2013...
March 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/28463883/htlv-1-infection-and-disease-in-spain
#18
Carmen de Mendoza, Estrella Caballero, Antonio Aguilera, Silvia Requena, Raúl Ortiz de Lejarazu, María Pirón, Rocío González, Ana Jiménez, Lourdes Roc, Ana Treviño, Rafael Benito, Miriam Fernández-Alonso, Aitziber Aguinaga, Carmen Rodríguez, Juan García-Costa, Lidia Blanco, José M Ramos, Enrique Calderón, José M Eirós, Silvia Sauleda, Pablo Barreiro, Vicente Soriano
: Human T-lymphotropic virus type 1 (HTLV-1) infection is a neglected disease despite roughly 15 million people are chronically infected worldwide. Lifelong less than 10% of carriers develop life-threatening diseases, mostly a subacute myelopathy known as tropical spastic paraparesis (TSP) and a lymphoproliferative disorder named adult T-cell leukemia (ATL). HTLV-1 is efficiently transmitted perinatally (breastfeeding), sexually (more from male to female) and parenterally (transfusions, injection drug use and transplants)...
May 1, 2017: AIDS
https://www.readbyqxmd.com/read/28453188/description-of-15-dna-positive-and-antibody-negative-window-period-blood-donations-identified-during-prospective-screening-for-babesia-microti
#19
Erin D Moritz, Mary Ellen Hewins, Victor P Berardi, Roger Y Dodd, Susan L Stramer
BACKGROUND: Blood donation screening detecting only antibodies fails to identify donors in the earliest stage of infection, before a detectable immunologic response, that is, the "window period" (WP). We present data on WP donations identified during prospective screening for Babesia microti, a transfusion-transmissible parasite of increasing concern in the United States. STUDY DESIGN AND METHODS: Blood donations collected in Connecticut, Massachusetts, Minnesota, and Wisconsin were screened using polymerase chain reaction (PCR) and arrayed fluorescence immunoassay (AFIA) to detect B...
April 28, 2017: Transfusion
https://www.readbyqxmd.com/read/28451477/knowledge-and-attitude-about-sexually-transmitted-infections-amongst-truck-drivers-in-southern-punjab-pakistan
#20
Rizwan Ishtiaq, Ammar Asif, Abdur Rehman Jamil, Areba Irfan, Daniyal Ishtiaq
INTRODUCTION: There is very limited knowledge about sexually transmitted infections (STIs) transmission and prevention present amongst high-risk groups such as truck drivers in Pakistan because of lack of awareness and understanding about barrier techniques. OBJECTIVE: The aim of this study was to collect and access the data gathered from truck drivers about symptoms of STIs, their attitude towards hazards of multiple sexual partners, homosexuality, transmission and consequences of STIs, and their perception about preventing it using condoms and other barrier methods...
March 26, 2017: Curēus
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