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https://www.readbyqxmd.com/read/29141038/depot-specific-inflammation-with-decreased-expression-of-atm2-in-white-adipose-tissues-induced-by-high-margarine-lard-intake
#1
Nannan Wang, Jie Guo, Fuding Liu, Mingxia Wang, Chuntao Li, Lihong Jia, Lingling Zhai, Wei Wei, Yinglong Bai
A high-fat diet has been recognized as an important risk factor of obesity, with variable impacts of different fatty acid compositions on the physiological process. To understand the effects of a high-margarine/lard diet, which is a major source of trans fatty acids (TFAs)/ saturated fatty acids (SFAs), elaidic acid as a biomarker of margarine intake was used to screen affected adipokines on mature human adipocytes in vitro. Weaned male Wistar rats were fed a high-fat diet enriched with margarine/lard to generate obesity-prone (OP) and obesity-resistant (OR) models, which were then used to explore the inflammatory responses of depot-specific white adipose tissue...
2017: PloS One
https://www.readbyqxmd.com/read/29140550/lncrna-h19-interacts-with-polypyrimidine-tract-binding-protein-1-to-reprogram-hepatic-lipid-homeostasis
#2
Chune Liu, Zhihong Yang, Jianguo Wu, Li Zhang, Sangmin Lee, Dong-Ju Shin, Melanie Tran, Li Wang
H19 is an imprinted long non-coding RNA abundantly expressed in embryonic liver and repressed after birth. Here we show that H19 serves as a lipid sensor by synergizing with RNA-binding protein PTBP1 to modulate hepatic metabolic homeostasis. H19RNA interacts with PTBP1 to facilitate its association with SREBP1c mRNA and protein, leading to increased stability and nuclear transcriptional activity. H19 and PTBP1 are upregulated by fatty acids in hepatocytes and in diet-induced fatty liver, which further augments lipid accumulation...
November 15, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29139309/polyphenolic-characterisation-of-plant-mixture-lisosan%C3%A2-reduction-and-its-hypocholesterolaemic-effect-in-high-fat-diet-fed-mice
#3
Rossella Russo, Laura Pucci, Lucia Giorgetti, Július Árvay, Francesco Vizzarri, Vincenzo Longo, Luisa Pozzo
Lisosan® Reduction is a plant mixture produced from powder of fermented Triticum aestivum (Lisosan® G), Desmodium adscendens, Malus domestica, Picrorhiza kurroa and Hordeum vulgare. The aim of this study was to characterise the phenolic profile of Lisosan® Reduction and to evaluate the effects of aqueous extract on mice fed a high fat diet (HFD). Syringic acid, trans sinapic acid and neochlorogenic acid were identified by HPLC-DAD to be the dominant polyphenols of Lisosan® Reduction, followed by vitexin, trans p-coumeric acid and trans ferulic acid...
November 15, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29135972/roux-en-y-gastric-bypass-reduces-plasma-cholesterol-in-diet-induced-obese-mice-by-affecting-trans-intestinal-cholesterol-excretion-and-intestinal-cholesterol-absorption
#4
C Blanchard, F Moreau, A Ayer, L Toque, D Garçon, L Arnaud, F Borel, A Aguesse, M Croyal, M Krempf, X Prieur, M Neunlist, B Cariou, C Le May
OBJECTIVE: Bariatric surgery appears as the most efficient therapeutic alternative in morbidly obese patients. In addition to its efficiency to decrease body weight, it also improves metabolic complications associated to morbid obesity, including dyslipidemia. Although the cholesterol-lowering effect varies with the bariatric procedures, the underlying molecular mechanisms remain poorly defined. This study aims to assess the consequence of both restrictive (sleeve gastrectomy; SG) and malabsorptive (Roux-en-Y gastric bypass; RYGB) procedures on cholesterol metabolism in mice...
September 28, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29130901/quantification-of-fat-fraction-in-lumbar-vertebrae-correlation-with-age-and-implications-for-bone-marrow-dosimetry-in-molecular-radiotherapy
#5
Maikol Salas-Ramirez, Johannes Tran-Gia, Christian Kesenheimer, Andreas Max Weng, Aleksander Kosmala, Anke Heidemeier, Herbert Koestler, Michael Lassmann
Absorbed dose to active bone marrow is a predictor of hematological toxicity in molecular radiotherapy. Due to the complex composition of bone marrow tissue, the necessity to improve the personalized dosimetry has led to the application of non-conventional imaging methods in nuclear medicine. The aim of this study is to apply magnetic resonance imaging (MRI) for quantification of the fat fraction in lumbar vertebrae and to analyze its implications for bone marrow dosimetry. Methods First, a highly accelerated two-point Dixon MRI sequence for fat-water separation was validated in a 3T system against the magnetic resonance spectroscopy (MRS) gold standard...
November 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29128224/effect-of-2-hydroxy-4-methylthio-butanoate-hmtba-on-risk-of-biohydrogenation-induced-milk-fat-depression
#6
M Baldin, G I Zanton, K J Harvatine
Diet-induced milk fat depression (MFD) is a multifactorial condition resulting from the interaction of numerous risk factors, including diet fermentability and unsaturated fatty acids concentration, feed additives, and individual cow effects. 2-Hydroxy-4-(methylthio)butanoate (HMTBa) is a methionine analog that has been observed to increase milk fat in some cases, and interactions with MFD risk factors may exist. The objective was to evaluate the effect of HMTBa supplementation on milk fat synthesis in cows with different levels of milk production and fed diets with increasing risk of biohydrogenation-induced MFD...
November 8, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29128213/the-effects-of-feeding-a-partial-mixed-ration-plus-a-top-dress-before-feeding-on-milk-production-and-the-daily-rhythm-of-feed-intake-and-plasma-hormones-and-metabolites-in-dairy-cows
#7
M Niu, K J Harvatine
Total mixed rations (TMR) are commonly fed to dairy cows with a goal of reducing ruminal acidosis, but the daily pattern of feed intake has major implication for rumen fermentation and postabsorptive physiology. Generally there is low feed intake during the overnight period and high intake after feeding and during the afternoon. The objective of this study was to determine if feeding a partial mixed ration (PMR) plus a high starch top-dress before feeding of the PMR would improve production and modify key daily rhythms...
November 8, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29125718/effects-of-high-and-low-fat-meals-on-the-pharmacokinetics-of-ozanimod-a-novel-sphingosine-1-phosphate-receptor-modulator
#8
Jonathan Q Tran, Jeffrey P Hartung, Cindy-Ann Tompkins, Paul A Frohna
Ozanimod (RPC1063) is an oral selective modulator of the sphingosine-1-phosphate 1 and 5 receptors under development for the treatment of relapsing multiple sclerosis and inflammatory bowel disease. The effects of high-fat and low-fat meals on the pharmacokinetics (PK) of a single oral dose of ozanimod were evaluated in 24 healthy volunteers in a randomized, open-label crossover trial. Each subject received a 1-mg dose of ozanimod hydrochloride under 3 meal conditions (fasted, high-fat, and low-fat), each separated by 7 days...
November 10, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29122042/peroxisome-proliferator-activated-receptor-gamma-ppar%C3%AE-agonist-fails-to-overcome-trans-10-cis-12-conjugated-linoleic-acid-cla-inhibition-of-milk-fat-in-dairy-sheep
#9
E C Sandri, M Camêra, E M Sandri, K J Harvatine, D E De Oliveira
The trans-10, cis-12 conjugated linoleic acid (CLA) causes milk fat depression by downregulating expression of genes and transcription factors involved in lipogenesis and it has been proposed that peroxisome proliferator-activated receptor gamma (PPARγ) can be inhibited by trans-10, cis-12 CLA. The PPARγ is a nuclear receptor activated by natural or synthetic ligands and promotes expression of lipogenic genes and its effect on mammary lipogenesis and the interaction with trans-10, cis-12 CLA in lactating ewes was evaluated using thiazolidinedione (TZD), a chemical PPARγ agonist...
November 10, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29121493/prevalence-of-consumption-and-nutritional-content-of-breakfast-meal-among-adolescents-from-the-brazilian-national-dietary-survey
#10
Jaqueline L Pereira, Michelle A de Castro, Sinead Hopkins, Carolyn Gugger, Regina M Fisberg, Mauro Fisberg
OBJECTIVE: To estimate the prevalence of breakfast consumption and describe the foods and nutrients consumed at this meal and throughout the day by Brazilian adolescents. METHOD: A total of 7276 adolescents aged 10-19 years were evaluated in the Brazilian National Dietary Survey 2008-9, a population-based cross-sectional study. Individuals' information was collected at home. Dietary data were obtained by two food records. Breakfast was defined as the first eating occasion of the day that occurred between 6 and 9:59am...
November 6, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/29120303/lunch-is-ready%C3%A2-but-not-healthy-an-analysis-of-lunches-served-in-childcare-centres-in-two-canadian-provinces
#11
Stephanie Ward, Mathieu Bélanger, Denise Donovan, Hassan Vatanparast, Rachel Engler-Stringer, Anne Leis, Natalie Carrier
OBJECTIVES: Childcare centres (CCs) typically offer one meal and snacks daily. This study compared what is served in CCs with what the nutritional recommendations are; described and compared the nutritional composition of lunches served in CCs in New Brunswick and Saskatchewan; and examined differences between French and English, and urban and rural centres. METHODS: The study involved 61 randomly selected CCs in New Brunswick and Saskatchewan, Canada. Lunch content was measured on two consecutive days by weighing each food item served to children and by visually documenting the food items using digital photography...
November 9, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/29118032/impact-of-nonoptimal-intakes-of-saturated-polyunsaturated-and-trans-fat-on-global-burdens-of-coronary-heart-disease
#12
(no author information available yet)
No abstract text is available yet for this article.
November 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29108723/cardiovascular-respiratory-and-related-disorders-key-messages-from-disease-control-priorities-3rd-edition
#13
REVIEW
Dorairaj Prabhakaran, Shuchi Anand, David Watkins, Thomas Gaziano, Yangfeng Wu, Jean Claude Mbanya, Rachel Nugent
Cardiovascular, respiratory, and related disorders (CVRDs) are the leading causes of adult death worldwide, and substantial inequalities in care of patients with CVRDs exist between countries of high income and countries of low and middle income. Based on current trends, the UN Sustainable Development Goal to reduce premature mortality due to CVRDs by a third by 2030 will be challenging for many countries of low and middle income. We did systematic literature reviews of effectiveness and cost-effectiveness to identify priority interventions...
November 3, 2017: Lancet
https://www.readbyqxmd.com/read/29106966/single-step-preparation-of-selected-biological-fluids-for-the-high-performance-liquid-chromatographic-analysis-of-fat-soluble-vitamins-and-antioxidants
#14
Giacomo Lazzarino, Salvatore Longo, Angela Maria Amorini, Valentina Di Pietro, Serafina D'Urso, Giuseppe Lazzarino, Antonio Belli, Barbara Tavazzi
Fat-soluble vitamins and antioxidants are of relevance in health and disease. Current methods to extract these compounds from biological fluids mainly need use of multi-steps and multi organic solvents. They are time-consuming and difficult to apply to treat simultaneously large sample number. We here describe a single-step, one solvent extraction of fat-soluble vitamins and antioxidants from biological fluids, and the chromatographic separation of all-trans-retinoic acid, 25-hydroxycholecalciferol, all-trans-retinol, astaxanthin, lutein, zeaxanthin, trans-β-apo-8'-carotenal, γ-tocopherol, β-cryptoxanthin, α-tocopherol, phylloquinone, lycopene, α-carotene, β-carotene and coenzyme Q10...
December 8, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29103706/alterations-in-ruminal-bacterial-populations-at-induction-and-recovery-from-diet-induced-milk-fat-depression-in-dairy-cows
#15
D W Pitta, N Indugu, B Vecchiarelli, D E Rico, K J Harvatine
Ten ruminally cannulated Holstein cows were used in a crossover design that investigated changes in ruminal bacterial populations in response to induction and recovery from diet-induced milk fat depression (MFD). Further, the effect on the ruminal microbiota of the cows with diet-induced milk fat depression inoculated with rumen contents from non-milk fat-depressed donor cows was evaluated. Milk fat depression was induced during the first 10 d of each period by feeding a low-fiber, high-starch, and high-polyunsaturated fatty acid diet (26...
November 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29095919/raldh1-promotes-adiposity-during-adolescence-independently-of-retinal-signaling
#16
Di Yang, Charles R Krois, Priscilla Huang, Jinshan Wang, Jin Min, Hong Sik Yoo, Yinghua Deng, Joseph L Napoli
All-trans-retinoic acid (RA) inhibits adipogenesis in established preadipocyte cell lines. Dosing pharmacological amounts of RA reduces weight gain in mice fed a high-fat diet, i.e. counteracts diet-induced obesity (DIO). The aldehyde dehydrogenase Raldh1 (Aldh1a1) functions as one of three enzymes that converts the retinol metabolite retinal into RA, and one of many proteins that contribute to RA homeostasis. Female Raldh1-ablated mice resist DIO. This phenotype contrasts with ablations of other enzymes and binding-proteins that maintain RA homeostasis, which gain adiposity...
2017: PloS One
https://www.readbyqxmd.com/read/29094956/food-addiction-prevalence-and-concurrent-validity-in-african-american-adolescents-with-obesity
#17
Erica M Schulte, Angela J Jacques-Tiura, Ashley N Gearhardt, Sylvie Naar
Food addiction, measured by the Yale Food Addiction Scale (YFAS), has been associated with obesity, eating-related problems (e.g., bingeing), and problematic consumption of highly processed foods. Studies on this topic have primarily examined adult samples with an overrepresentation of White individuals, and little is known about addictive-like eating in adolescents, particularly African American adolescents who exhibit high rates of obesity and eating pathology. The current study examined the prevalence of food addiction and its convergent validity with percent overweight, eating-related problems, and self-reported dietary intake in a sample of 181 African American adolescents with obesity...
November 2, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29081505/serotonin-prevents-differentiation-into-brown-adipocytes-and-induces-trans-differentiation-into-white-adipocytes
#18
S Rozenblit-Susan, N Chapnik, O Froy
BACKGROUND/OBJECTIVES: Serotonin is synthesized by many cells in the periphery to affect vasoconstriction, intestinal motility, and glucose and lipid metabolism. It has recently been shown that serotonin leads to fat accumulation in white adipose tissue (WAT). However, the direct effect of serotonin on adipose tissue (BAT) differentiation and metabolism is limited. Therefore, our aim was to investigate the effect of serotonin on brown adipocyte metabolism and differentiation. METHODS: Non-differentiated HIB1B cells and differentiated HIB1B brown adipocytes were treated with serotonin and their metabolism and differentiation examined...
October 30, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29076225/association-of-genetic-variants-and-expression-levels-of-porcine-fabp4-and-fabp5-genes
#19
M Ballester, A Puig-Oliveras, A Castelló, M Revilla, A I Fernández, J M Folch
The FABP4 and FABP5 genes, coding for fatty acid transport proteins, have long been studied as positional candidate genes for SSC4 QTL affecting fat deposition and composition traits in pigs. Polymorphisms in these genes, FABP4:g.2634_2635insC and FABP5:g.3000T>G, have previously been associated with fatness traits in an Iberian by Landrace cross (IBMAP). The aim of the present work was to evaluate the functional implication of these genetic variants. For this purpose, FABP4 and FABP5 mRNA expression levels in 114 BC1_LD animals (25% Iberian × 75% Landrace) were analyzed using real-time quantitative PCR in backfat and muscle...
October 27, 2017: Animal Genetics
https://www.readbyqxmd.com/read/29062061/a-maternal-two-meal-feeding-sequence-with-varying-crude-protein-affects-milk-lipid-profile-in-a-sow-piglet-model
#20
Xin Wu, Chunyan Xie, Xiaoyun Guo, Cimin Long, Tianyong Zhang, Tianzeng Gao, Yulong Yin
The effects of a two-meal feeding sequence on production performance and milk lipid profile were investigated. Sixty pregnant sows (d 85 of gestation) were assigned to 3 groups: 2 C group (fed a control crude protein [CP] diet at 0600 and 1500 daily), LH group (fed a low CP diet and a high CP diet at 0600 and 1500), or HL group (fed a high CP diet and a low CP diet at 0600 and 1500). Reproductive performance of sows, and lipid profiles of plasma and milk were measured. Results showed that the HL feeding sequence dramatically increased average piglet weight/litter, average daily gain of piglet/litter, and milk production of sows...
October 23, 2017: Scientific Reports
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