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https://www.readbyqxmd.com/read/28432078/effect-of-4-5-6-7-8-tetrahydro-5-5-8-8-tetramethyl-2-naphthalenyl-carbamoyl-benzoic-acid-am80-on-alveolar-regeneration-in-adiponectin-deficient-mice-showing-a-chronic-obstructive-pulmonary-disease-like-pathophysiology
#1
Hitomi Sakai, Michiko Horiguchi, Tomomi Akita, Chihiro Ozawa, Mai Hirokawa, Yuki Oiso, Harumi Kumagai, Yoshito Takeda, Isao Tachibana, Norikazu Maeda, Chikamasa Yamashita
Chronic obstructive pulmonary disease (COPD) is an intractable pulmonary disease that causes widespread and irreversible alveolar collapse. Although COPD occurs worldwide, only symptomatic therapy is currently available. The objective of the present study was the development of therapeutic agents to eradicate COPD. Therefore, we focused on 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) carbamoyl] benzoic acid (Am80), which is a derivative of all-trans retinoic acid. We evaluated the effects of Am80 on alveolar repair in a novel COPD model of adiponectin-deficient mice...
April 21, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28429914/the-presence-and-accuracy-of-nutritional-labelling-of-pre-packaged-foods-in-shanghai
#2
Kaimeng Kong, Fu Liu, Yexuan Tao
BACKGROUND AND OBJECTIVES: The Chinese government officially enacted the Regulation on the Management of Food Nutrition Labelling in 2007 and the General Rules for Nutrition Labelling of Pre-packaged Foods in 2011. Our investigation examined the presence and accuracy of nutrition labelling of pre-packaged foods in Shanghai and provides baseline data for future studies. METHODS AND STUDY DESIGN: Nutrition labels on pre-packaged foods were recorded by photograph, transcription, or purchase in four supermarkets in Shanghai...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28424192/sodium-sugar-and-fat-content-of-complementary-infant-and-toddler-foods-sold-in-the-united-states-2015
#3
Joyce Maalouf, Mary E Cogswell, Marlana Bates, Keming Yuan, Kelley S Scanlon, Pamela Pehrsson, Janelle P Gunn, Robert K Merritt
Background: As part of a healthy diet, limiting intakes of excess sodium, added sugars, saturated fat, and trans fat has been recommended. The American Heart Association recommends that children aged <2 y should avoid added sugars.Objective: We sought to determine commercial complementary infant-toddler food categories that were of potential concern because of the sodium, added sugar, saturated fat, or trans fat content.Design: Nutrition label information (e.g., serving size, sodium, saturated fat, trans fat) for 1032 infant and toddler foods was collected from manufacturers' websites and stores from May to July 2015 for 24 brands, which accounted for >95% of infant-toddler food sales...
April 19, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28412693/feeding-angptl4-mice-trans-fat-promotes-foam-cell-formation-in-mesenteric-lymph-nodes-without-leading-to-ascites
#4
Antwi Boasiako Oteng, Asmita Bhattacharya, Susanne Brodesser, Ling Qi, Nguan Soon Tan, Sander Kersten
ANGPTL4 regulates plasma triglyceride levels by inhibiting lipoprotein lipase. Inactivation of ANGPTL4 decreases plasma triglycerides and reduces risk of coronary artery disease. Unfortunately, targeting ANGPTL4 for the therapeutic management of dyslipidemia and atherosclerosis is hampered by the observation that mice and monkeys in which ANGPTL4 is inactivated exhibit lipid accumulation in mesenteric lymph nodes. In mice these pathological events exclusively unfold upon feeding a high saturated fatty acid diet and are followed by an ultimately lethal pro-inflammatory response and chylous ascites...
April 15, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28411685/antihyperglycemic-antihyperlipidemic-and-antioxidant-effects-of-standard-ethanol-extract-of-bombax-ceiba-leaves-in-high-fat-diet-and-streptozotocin-induced-type-2-diabetic-rats
#5
Guang-Kai Xu, Xiao-Ying Qin, Guo-Kai Wang, Guo-Yong Xie, Xu-Sen Li, Chen-Yu Sun, Bao-Lin Liu, Min-Jian Qin
The present study aimed at exploring the therapeutic potential of standard extract of Bombax ceiba L. leaves (BCE) in type 2 diabetic mellitus (T2DM). Oral administration of BCE at doses of 70, 140, and 280 mg·kg(-1), to the normal rats and the high-fat-diet- and streptozotocin-induced T2DM rats were carried out. Effects of BCE on blood glucose, body weight, and a range of serum biochemical parameters were tested, and histopathological observation of pancreatic tissues was also performed. HPLC-ESI-Q/TOF-MS/MS analysis indicated that the chemical composition of BCE mainly contained mangiferin, isoorientin, vitexin, isomangiferin, isovitexin, quercetin hexoside, 2'-trans-O-cumaroyl mangiferin, and nigricanside...
March 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28398243/neonatal-citrulline-supplementation-and-later-exposure-to-a-high-fructose-diet-in-rats-born-with-a-low-birth-weight-a-preliminary-report
#6
Nhat-Thang Tran, Marie-Cécile Alexandre-Gouabau, Anthony Pagniez, Khadija Ouguerram, Clair-Yves Boquien, Norbert Winer, Dominique Darmaun
A low birth weight (LBW) leads to a higher risk of metabolic syndrome in adulthood. Literature suggests that citrulline supplementation in adulthood prevents the effect of a high fructose diet on energy metabolism. Whether neonatal citrulline supplementation would alter early growth or energy metabolism in the long-term in rats with LBW is unknown. LBW pups born from dams fed a low (4%) protein diet, were nursed by normally-fed dams and received isonitrogenous supplements of either l-citrulline or l-alanine by gavage from the sixth day of life until weaning, and were subsequently exposed to 10%-fructose in drinking water from weaning to 90 days of age...
April 11, 2017: Nutrients
https://www.readbyqxmd.com/read/28390715/effects-of-feeding-extruded-linseed-on-production-performance-and-milk-fatty-acid-profile-in-dairy-cows-a-meta-analysis
#7
T Meignan, C Lechartier, G Chesneau, N Bareille
The objectives of this study were to quantify the effects on production performance and milk fatty acid (FA) profile of feeding dairy cows extruded linseed (EL), a feed rich in α-linolenic acid, and to assess the variability of the responses related to the dose of EL and the basal diet composition. This meta-analysis was carried out using only data from trials including a control diet without fat supplementation. The dependent variables were defined by the mean differences between values from EL-supplemented groups and values from control groups...
April 5, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28381787/effect-of-fatty-acid-chain-length-on-the-crystallization-behavior-of-trans-free-margarine-basestocks-during-storage
#8
Peng Hu, Xuebing Xu, Liangli Lucy Yu
In order to obtain margarine free of trans-fatty acids, four interesterified basestocks were prepared by chemical interesterification (CIE) of oil blends. Different ratios of palm stearin, palm olein and soybean oil were mixed without and with 1) fully hydrogenated Acer truncatum oil (FHATO), 2) fully hydrogenated rapeseed oil or 3) palm kernel oil containing a similar amount of saturated, monounsaturated and polyunsaturated fatty acids, but different saturated fatty acid length for CIE. Compared to the physical blends, the CIE samples demonstrated lower slip melting points and decreased solid fat contents, especially at high temperatures, indicating that the CIE samples might have improved mouthfeel...
2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28372466/structural-changes-in-biscuits-made-with-cellulose-emulsions-as-fat-replacers
#9
Teresa Sanz, Amparo Quiles, Ana Salvador, Isabel Hernando
Biscuits are a popular baked cereal food much appreciated by consumers. In the last few years, cellulose derivatives have been successfully used as fat replacers in biscuits. In this way, not only is the total amount of fat reduced but also the saturated fatty acids and the trans fatty acids are eliminated. The aim of this study is to increase understanding of the functionality of different cellulose ether emulsions used as fat replacers in biscuits. For this purpose, three emulsions with different cellulose ethers were designed: hydroxypropyl methylcellulose, methylcellulose and methylcellulose with greater methoxyl substitution (MCH)...
January 1, 2017: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
https://www.readbyqxmd.com/read/28361752/an-empirically-derived-dietary-pattern-associated-with-breast-cancer-risk-is-validated-in-a-nested-case-control-cohort-from-a-randomized-primary-prevention-trial
#10
Brandon H Hidaka, Bruce F Kimler, Carol J Fabian, Susan E Carlson
BACKGROUND & AIMS: We reported an association between cytologic atypia, a reversible biomarker of breast cancer risk, and lower omega-3/omega-6 fatty acid ratio in blood and breast tissue. Our goal was to develop and validate a dietary pattern index in this high-risk sample of U.S. women, and test its capacity to predict incidence in a nested case-control cohort of Canadian women from a randomized trial of a low-fat dietary intervention for primary prevention of breast cancer. METHODS: Food intake was measured by food frequency questionnaire in the U...
February 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28351404/longitudinal-10-year-changes-in-dietary-intake-and-associations-with-cardio-metabolic-risk-factors-in-the-northern-sweden-health-and-disease-study
#11
Anna Winkvist, Sofia Klingberg, Lena Maria Nilsson, Maria Wennberg, Frida Renström, Göran Hallmans, Kurt Boman, Ingegerd Johansson
BACKGROUND: Dietary risks today constitute the largest proportion of disability-adjusted life years (DALYs) globally and in Sweden. An increasing number of people today consume highly processed foods high in saturated fat, refined sugar and salt and low in dietary fiber, vitamins and minerals. It is important that dietary trends over time are monitored to predict changes in disease risk. METHODS: In total, 15,995 individuals with two visits 10 (±1) years apart in the population-based Västerbotten Intervention Programme 1996-2014 were included...
March 28, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28339665/an-evaluation-of-a-public-private-partnership-to-reduce-artificial-trans-fatty-acids-in-england-2011-16
#12
C Knai, L James, M Petticrew, E Eastmure, M A Durand, N Mays
The Public Health Responsibility Deal (RD) is a public-private partnership in England involving voluntary pledges between government, and business and other public organizations to improve public health. One such voluntary pledge refers to the reduction of trans fatty acids (TFAs) in the food supply in England by either pledging not to use artificial TFAs or pledging artificial TFA removal. This paper evaluates the RD's effectiveness at encouraging signatory organizations to remove artificially produced TFAs from their products...
February 17, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28338587/medial-row-perforators-are-associated-with-higher-rates-of-fat-necrosis-in-bilateral-diep-flap-breast-reconstruction
#13
Parisa Kamali, Michelle Lee, Babette E Becherer, Winona Wu, Daniel Curiel, Bao Ngoc N Tran, Adam M Tobias, Samuel J Lin, Bernard T Lee
BACKGROUND: The purpose of this study is to evaluate perfusion related complications in bilateral deep inferior epigastric perforator (DIEP) flap breast reconstruction based on perforator selection. METHODS: A retrospective review of a prospectively maintained database was performed on all patients undergoing bilateral DIEP flap reconstruction at a single institution between 2004-2014. The hemiflaps were separated into three cohorts based on perforator location: lateral row only, medial row only, and medial plus lateral row...
March 3, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28333357/dietary-patterns-foods-and-nutrients-in-male-fertility-parameters-and-fecundability-a-systematic-review-of-observational-studies
#14
Albert Salas-Huetos, Mònica Bulló, Jordi Salas-Salvadó
BACKGROUND: Infertility is a global public health issue, affecting 15% of all couples of reproductive age. Male factors, including decreased semen quality, are responsible for ~25% of these cases. The dietary pattern, the components of the diet and nutrients have been studied as possible determinants of sperm function and/or fertility. OBJECTIVE AND RATIONALE: Previous systematic reviews have been made of the few heterogeneous low-quality randomized clinical trials (RCTs) conducted in small samples of participants and investigating the effect of specific nutrients and nutritional supplements on male infertility...
March 10, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28331816/inhibition-of-fat-cell-differentiation-in-3t3-l1-pre-adipocytes-by-all-trans-retinoic-acid-integrative-analysis-of-transcriptomic-and-phenotypic-data
#15
Katharina Stoecker, Steffen Sass, Fabian J Theis, Hans Hauner, Michael W Pfaffl
The process of adipogenesis is controlled in a highly orchestrated manner, including transcriptional and post-transcriptional events. In developing 3T3-L1 pre-adipocytes, this program can be interrupted by all-trans retinoic acid (ATRA). To examine this inhibiting impact by ATRA, we generated large-scale transcriptomic data on the microRNA and mRNA level. Non-coding RNAs such as microRNAs represent a field in RNA turnover, which is very important for understanding the regulation of mRNA gene expression. High throughput mRNA and microRNA expression profiling was performed using mRNA hybridisation microarray technology and multiplexed expression assay for microRNA quantification...
March 2017: Biomolecular Detection and Quantification
https://www.readbyqxmd.com/read/28330733/what-do-children-eat-in-the-summer-a-direct-observation-of-summer-day-camps-that-serve-meals
#16
Erica L Kenney, Rebekka M Lee, Carolyn J Brooks, Angie L Cradock, Steven L Gortmaker
BACKGROUND: More than 14 million children in the United States attend summer camp annually, yet little is known about the food environment in day camps. OBJECTIVE: Our aim was to describe the nutritional quality of meals served to, brought by, and consumed by children attending summer day camps serving meals and snacks, and to describe camp water access. DESIGN: We conducted a cross-sectional study. PARTICIPANTS/SETTINGS: Participants were 149 children attending five summer camps in Boston, MA, in 2013...
March 16, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28326519/influence-of-diet-on-the-risk-of-developing-endometriosis
#17
Joanna Jurkiewicz-Przondziono, Magdalena Lemm, Anna Kwiatkowska-Pamuła, Ewa Ziółko, Mariusz K Wójtowicz
Endometriosis is a hormone-dependent chronic inflammatory disease characterized by the presence of endometrium beyond the uterine cavity. The disease affects 5-15% of women of child-bearing age, 30-50% of whom suffer from infertility. Understanding the role of dietary factors in the development of endometriosis is critical to development of effective dietary instructions for prevention. Existing studies concerning nutrition and endometriosis suggest that diet is a potentially modifiable risk factor for endometriosis...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28322379/wine-lees-modulate-lipid-metabolism-and-induce-fatty-acid-remodelling-in-zebrafish
#18
M Caro, A Sansone, J Amezaga, V Navarro, C Ferreri, I Tueros
This study investigates the ability of a polyphenolic extract obtained from a wine lees by-product to modulate zebrafish lipid metabolism. Lees from a Spanish winery were collected and the polyphenolic extract was chemically characterised in terms of antioxidant capacity, total phenolic content and the individual main phenolic compounds. The effects of the extract on lipid metabolism were evaluated using a zebrafish animal model. Lees are rich in polyphenols (42.33 mg gallic acid equivalent per g dry matter) with high antioxidant capacity (56...
April 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28319852/pterostilbene-a-dimethylated-analog-of-resveratrol-promotes-energy-metabolism-in-obese-rats
#19
Koji Nagao, Tomoyuki Jinnouchi, Shunichi Kai, Teruyoshi Yanagita
Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a dimethylated analog of resveratrol and has been reported to exert various pharmacological effects. In this study, we evaluated the effect of pterostilbene on the pathogenesis of obesity and energy metabolism in obese rats. Pterostilbene significantly activates silent mating type information regulation 2 homolog-1 and peroxisome proliferator-activated receptor-alpha in vitro. At 4 weeks a 0.5% pterostilbene diet markedly suppressed the abdominal white adipose tissue (WAT) accumulation in obese rats...
March 8, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28316781/dyspnea-and-dysphagia-associated-to-hypopharyngeal-fibrolipoma-a-case-report
#20
Marco A Mendez Saenz, Vicente J Villagomez Ortiz, Mario Jesús Jr Villegas González, Baltazar Gonzalez Andrade, Miguel Angel Liñan Arce, German A Soto-Galindo, José Luis Treviño González
Fibrolipomas are benign lesions conformed by fat and connective tissue, classified as histologic variants of lipomas. They are rarely located in the head and neck and represent less than 0.6% of the benign tumors of the larynx and hypopharynx. Their clinical presentation depends on its location and size. We present the case of a 51-year-old male patient who reported progressive dyspnea, dysphagia and obstructive sleep symptoms with a duration of 3 months, without apparent cause. A pharyngolaryngeal fiberoptic endoscopy showed a smooth, rounded mass in the posterior wall of the hypopharynx, partially obstructing the laryngeal vestibule, creating a valve effect...
April 2017: Annals of Medicine and Surgery
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