Vinicius Daguano Gastaldi, Justus Bh Wilke, Cosima A Weidinger, Carolin Walter, Nadine Barnkothe, Bianca Teegen, Felix Luessi, Winfried Stöcker, Fred Lühder, Martin Begemann, Frauke Zipp, Klaus-Armin Nave, Hannelore Ehrenreich
BACKGROUND: Circulating autoantibodies (AB) against brain-antigens, often deemed pathological, receive increasing attention. We assessed predispositions and seroprevalence/characteristics of 49 AB in >7000 individuals. METHODS: Exploratory cross-sectional cohort study, investigating deeply phenotyped neuropsychiatric patients and healthy individuals of GRAS Data Collection for presence/characteristics of 49 brain-directed serum-AB. Predispositions were evaluated through GWAS of NMDAR1-AB carriers, analyses of immune check-point genotypes, APOE4 status, neurotrauma...
October 30, 2022: Brain, Behavior, and Immunity