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Keratitis

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https://www.readbyqxmd.com/read/28820347/association-between-eye-diagnosis-and-positive-syphilis-test-results-in-a-large-urban-sexually-transmitted-infection-primary-care-clinic-population
#1
Ann-Marie Lobo, Yan Gao, Laura Rusie, Magda Houlberg, Supriya D Mehta
In 2015, the Centers for Disease Control and Prevention (CDC) and the American Academy of Ophthalmology (AAO) released clinical advisories on rising cases of ocular syphilis. We examined the association between eye disease and syphilis infection among primary care and sexually transmitted infection (STI) clinic patients attending an urban lesbian, gay, bisexual, transgender (LGBT) health center. We conducted a retrospective medical record review of all patients who underwent syphilis testing at Howard Brown Health between 1 January 2010 and 31 December 2015...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28817744/predictors-of-corneal-perforation-or-need-for-therapeutic-keratoplasty-in-severe-fungal-keratitis-a-secondary-analysis-of-the-mycotic-ulcer-treatment-trial-ii
#2
N Venkatesh Prajna, Tiruvengada Krishnan, Revathi Rajaraman, Sushila Patel, Ranjeet Shah, Muthiah Srinivasan, Manoranjan Das, Kathryn J Ray, Catherine E Oldenburg, Stephen D McLeod, Michael E Zegans, Nisha R Acharya, Thomas M Lietman, Jennifer Rose-Nussbaumer
Importance: Identifying patients with infectious keratitis who are at risk of experiencing a poor outcome may be useful to allocate resources toward high- risk patients, particularly in resource-poor settings. Objective: To determine baseline patient and ulcer characteristics that predict a high risk of developing corneal perforation and/or the need to undergo therapeutic penetrating keratoplasty (TPK). Design, Setting, and Participants: This is a secondary analysis of Mycotic Ulcer Treatment Trial II, a multicenter, double-masked, placebo-controlled randomized clinical trial that enrolled 240 patients with smear-positive filamentous fungal corneal ulcers who enrolled between May 2010 and August 2015...
August 17, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28815772/ectropion-improvement-with-topical-tazarotene-in-children-with-lamellar-ichthyosis
#3
Brooke Hanson, Lauren Becker, Kristen Hook, Ingrid Polcari, Raymond G Areaux, Sheilagh Maguiness
BACKGROUND/OBJECTIVES: Lamellar ichthyosis (LI) is a well-described phenotypic subtype of autosomal recessive congenital ichthyosis (ARCI). The condition typically presents at birth with collodion membrane and leads to thick, plate-like scaling of the skin throughout the body, alopecia, and prominent ocular manifestations. Ocular complications include bilateral cicatricial ectropion and lagophthalmos. These ocular complications can lead to chronic exposure keratitis and in some cases corneal ulceration and blindness...
August 17, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28815736/the-diagnosis-and-management-of-contact-lens-related-microbial-keratitis
#4
REVIEW
Nicole Carnt, Chameen Samarawickrama, Andrew White, Fiona Stapleton
Contact lens-associated microbial keratitis poses a diagnostic dilemma for optometrists on two fronts. The distinction between sterile inflammation and microbial infection is often blurred. In addition, there is a requirement with nearly 50 per cent of the Australian and New Zealand optometric profession being therapeutically endorsed, to distinguish between cases of infection that can be managed in the community verses those that require escalation to public hospitals that have access to laboratory diagnostic tools and advanced imaging techniques, such as in vivo confocal microscopy...
August 16, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28813424/risk-factors-and-causative-organisms-in-microbial-keratitis-in-daily-disposable-contact-lens-wear
#5
Fiona Stapleton, Thomas Naduvilath, Lisa Keay, Cherry Radford, John Dart, Katie Edwards, Nicole Carnt, Darwin Minassian, Brien Holden
PURPOSE: This study investigated independent risk factors and causative organisms in microbial keratitis in daily disposable contact lens (CL)-wearers. METHODS: A multisite prospective case-control study was undertaken. Cases were daily disposable CL-wearers attending Moorfields Eye Hospital with microbial keratitis and those reported through a one-year surveillance study in Australia and in New Zealand. A population-based telephone survey identified daily disposable CL-wearing controls...
2017: PloS One
https://www.readbyqxmd.com/read/28811501/characterisation-of-sterol-biosynthesis-and-validation-of-14%C3%AE-demethylase-as-a-drug-target-in-acanthamoeba
#6
Scott Thomson, Christopher A Rice, Tong Zhang, RuAngelie Edrada-Ebel, Fiona L Henriquez, Craig W Roberts
The soil amoebae Acanthamoeba causes Acanthamoeba keratitis, a severe sight-threatening infection of the eye and the almost universally fatal granulomatous amoebic encephalitis. More effective treatments are required. Sterol biosynthesis has been effectively targeted in numerous fungi using azole compounds that inhibit the cytochrome P450 enzyme sterol 14α-demethylase. Herein, using Gas Chromatography Mass Spectrometry (GCMS), we demonstrate that the major sterol of Acanthamoeba castellanii is ergosterol and identify novel putative precursors and intermediate sterols in its production...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810564/clinical-efficacy-of-conjunctival-flap-surgery-in-the-treatment-of-refractory-fungal-keratitis
#7
Honorine Nizeyimana, Dan-Dan Zhou, Xiu-Fen Liu, Xiao-Tao Pan, Cong Liu, Cheng-Wei Lu, Ji-Long Hao
The aim of the present study was to investigate the use and effectiveness of a selective, partial, pedunculated (tongue-shaped) conjunctival flap (CF) for the treatment of refractory fungal keratitis (FK) with or without perforation. A total of 31 cases of corneal diseases treated by CF surgery between April 2014 and October 2015 were evaluated. Among the 31 cases, 16 cases (male:female, 11:5) with FK were selected. Logistic regression analysis was used to investigate factors associated with complications of CF surgery...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810045/scleral-buckle-infection-with-pseudallescheria-boydii
#8
Janice C Law, Mark P Breazzano, Dean Eliott
Pseudallescheria boydii is a ubiquitous fungus that infects soft tissues and is known to cause ocular disease, including keratitis and endophthalmitis, in rare cases. In immunocompromised hosts, P. boydii can disseminate to or from the eye and other organs with lethal consequences. Postoperative P. boydii infections have, in rare cases, complicated several types of ocular surgeries in immunocompetent patients, but never for a scleral buckle. The authors present the first case of an infected scleral buckle from P...
August 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28808911/methicillin-resistant-staphylococcus-aureus-acute-keratitis-after-intracorneal-ring-segment-implantation
#9
Gonzalo García de Oteyza, Andrea Laiseca, Paola Sauvageot, Juan Álvarez de Toledo
INTRODUCTION: The purpose of this study was to report the first case of acute bacterial keratitis produced by methicillin-resistant Staphylococcus aureus after the implantation of two intracorneal ring segments during an uneventful procedure for treating keratoconus in a 13-year-old child. CASE REPORT: A patient with grade III keratoconus underwent an implantation of intracorneal ring segments with no complications during the procedure. Three days later, a whitish corneal infiltrate appeared in between the union of both corneal rings...
August 14, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28807756/first-time-identification-of-acanthamoeba-genotypes-in-the-cornea-samples-of-wild-birds-is-acanthamoeba-keratitis-making-the-predatory-birds-a-target
#10
Muhammet Karakavuk, Mehmet Aykur, Esra Atalay Şahar, Mehmet Karakuş, Duygu Aldemir, Ömer Döndüren, Hüseyin Gökhan Özdemir, Hüseyin Can, Adnan Yüksel Gürüz, Hande Dağcı, Mert Döşkaya
Acanthamoeba is a free-living amoeba which can be isolated from environment and among others well known as an opportunist protozoan parasite causing infections in humans and animals. Eyes are extremely important for the wild birds and losing sight ability due to Acanthamoeba can be dangerous. The studies on Acanthamoeba infection in wild birds is very few in world and Turkey therefore we aimed to screen deceased wild birds found in İzmir and Manisa provinces located in western Turkey using PCR and non-nutrition agar (NNA) plate method...
August 11, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28807636/visual-outcomes-and-complications-of-type-i-boston-keratoprosthesis-in-children-a-retrospective-multicenter-study-and-literature-review
#11
Simon S M Fung, Samir Jabbour, Mona Harissi-Dagher, Reginald R G Tan, Patrick Hamel, Kashif Baig, Asim Ali
PURPOSE: To report outcomes and complications of Boston type 1 keratoprosthesis (KPro) implantation in children. DESIGN: Retrospective, multicenter case series. PARTICIPANTS: All children 16 years of age or younger who underwent KPro surgery at 3 ophthalmology centers in Canada between January 2010 and November 2014. METHODS: Records of patients having undergone KPro implantation were reviewed. Data on preoperative characteristics, surgical procedure(s) performed, and postoperative outcomes were collected and analyzed...
August 11, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28803395/isolated-severe-microblepharon-in-a-neonate-a-rare-case
#12
Rachna Meel, Saranya Devi, Anita Ganger, Manasa S, Neelam Pushker
PURPOSE: To report a rare case of isolated severe microblepharon in a neonate. METHODS: A 27 days old male child was brought by parents with redness, photophobia and discharge for two weeks. Thorough ophthalmological and systemic examination was performed. RESULTS: The diagnosis of isolated severe microblepharon with infectious keratitis was made. After the appropriate management of infectious keratitis and achieving complete resolution, the child was subjected to bilateral lid reconstruction was done in the form of upper lid skin grafting and tarsorrhaphy and the patient is being followed up...
August 12, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28802816/safety-and-efficacy-of-an-8-week-regimen-of-grazoprevir-plus-ruzasvir-plus-uprifosbuvir-compared-with-grazoprevir-plus-elbasvir-plus-uprifosbuvir-in-participants-without-cirrhosis-infected-with-hepatitis-c-virus-genotypes-1-2-or-3-c-crest-1-and-c-crest-2-part
#13
Edward J Gane, Stephen Pianko, Stuart K Roberts, Alexander J Thompson, Stefan Zeuzem, Eli Zuckerman, Ziv Ben-Ari, Graham R Foster, Kosh Agarwal, Alex L Laursen, Jan Gerstoft, Wei Gao, Hsueh-Cheng Huang, Brian Fitzgerald, Doreen Fernsler, Jerry J Li, Anjana Grandhi, Hong Liu, Feng-Hsiu Su, Shuyan Wan, Zhen Zeng, Huei-Ling Chen, Frank J Dutko, Bach-Yen T Nguyen, Janice Wahl, Michael N Robertson, Eliav Barr, Wendy W Yeh, Rebeca M Plank, Joan R Butterton, Rafael Esteban
BACKGROUND: New hepatitis C virus (HCV) therapies with pan-genotypic efficacy are needed. The goals of part A of C-CREST-1 and C-CREST-2 were to compare the efficacies of two doses (300 mg or 450 mg once daily) of uprifosbuvir (MK-3682; NS5B inhibitor) in an 8-week regimen combined with grazoprevir (NS3/4A inhibitor; 100 mg once daily) and an NS5A inhibitor, either elbasvir (50 mg once daily) or ruzasvir (MK-8408; 60 mg once daily), and to evaluate the safety and tolerability of these combination regimens in individuals infected with genotypes 1, 2, or 3...
August 9, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28802685/results-at-7years-after-cross-linking-procedure-in-keratoconic-patients
#14
C Nicula, N Dorin, P R Nicolae
PURPOSE: Long-term evaluation of functional results based on visual acuity, keratometry, spherical equivalent and refractive cylinder in patients with progressive keratoconus treated with corneal collagen cross-linking (CXL). MATERIALS AND METHODS: We studied a group of 114 eyes of 91 consecutive patients treated from 2006 to 2009 by "Epi-off type" CXL. In the preoperative period, all patients had a complete ophthalmologic examination. The inclusion criteria were: patients aged 15 to 54years, with various stages of keratoconus, with a corneal thickness of at least 400μm at the thinnest point...
August 9, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28799957/potential-clue-to-the-pathogenesis-of-varicella-zoster-virus-stromal-keratitis
#15
Amde Selassie Shifera
No abstract text is available yet for this article.
August 9, 2017: Cornea
https://www.readbyqxmd.com/read/28791060/outcome-of-single-piece-intraocular-lens-sulcus-implantation-following-posterior-capsular-rupture-during-phacoemulsification
#16
Masomeh Mohebbi, Seyed Ali Bashiri, Seyed Farzad Mohammadi, Behnaz Samet, Fariba Ghassemi, Elham Ashrafi, Fatemeh Bazvand
PURPOSE: To assess the safety and outcome of single-piece posterior chamber intraocular lens (PC-IOL) implantation in the ciliary sulcus following posterior capsular rupture during cataract surgery. METHODS: Patients with posterior capsular rupture during cataract surgery with a single-piece acrylic IOL implanted into the ciliary sulcus were studied. Complete ocular examinations were performed after 6 months postoperatively. RESULTS: Twenty-four eyes were included...
July 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28775086/tailored-lamellar-keratoplasty-a-new-technique
#17
Mohammad Solaimani, Seyed Ali Tabatabaei, Zahra Fallah Tafti
We present a new method for treating complicated corneal gaps among patients who have previously undergone radial keratotomy (RK).After complete healing of a fungal keratitis in a patient who has undergone RK, we removed the oedematous corneal sector and put anterior tailored segment of a corneal button previously used for Descemet stripping endothelial keratoplasty. The patient's best-corrected visual acuity reached to 20/20 6 months later. This technique will compensate for oedematous parts without putting a significant effect on other parts such as purse string sutures...
August 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28770882/visual-outcome-in-patients-of-keratomycosis-at-a-tertiary-care-centre-in-larkana-pakistan
#18
Syed Imtiaz Ali Shah, Shujaat Ali Shah, Partab Rai, Naeem Akhtar Katpar, Safdar Ali Abbasi, Akbar Ali Soomro
OBJECTIVE: To study the post-treatment visual outcome of fungal keratitis. METHODS: This prospective study was carried out at Chandka Medical College and Hospital, Larkana, Pakistan, from March 2005 to March 2016. Patients with clinical features of fungal keratitis, with positive corneal scrapings for fungi, and those who followed up for a minimum period of three months after recovery from infection were included.Other causes of infectious keratitis were excluded...
July 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28761565/first-reported-case-of-donor-related-candida-endophthalmitis-after-descemet-membrane-endothelial-keratoplasty
#19
Matthew Thompson, David Carli
PURPOSE: To report the first case of Candida donor to host transmission following descemet membrane endothelial keratoplasty (DMEK). METHODS: A retrospective case report. RESULTS: A patient underwent uneventful DMEK. Following surgery the donor rim was culture positive for Candida. The patient developed fungal endophthalmitis that was treated medically with multiple injections of voriconazole and amphotericin. Medical treatment was unable to clear the infection and removal of the donor material was required...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28758436/-diagnostics-and-treatment-of-infectious-keratitis
#20
Nóra Szentmáry, László Módis, László Imre, Ágnes Füst, Loay Daas, Lenke Laurik, Berthold Seitz, Zoltán Zsolt Nagy
We summarize up-to-date diagnostic and treatment of infectious keratitis using literature data and some clinical examples. In the clinical practice, most commonly bacterial, herpetic, mycotic and acanthamoeba keratitis occur. Beside slitlamp examination, for diagnostic purpose, we analyse corneal sensitivity, perform in vivo confocal microscopy, polymerase-chain-reaction (PCR), in vitro culture and histological examination of the corneal sample. As conservative treatment we use primarily topical moxifloxacin or cephasolin with fortified tobramycin or gentamycin in bacterial, topical antiviral gel (in some cases in combination with systemic antiviral treatment) in part in combination with topical corticosteroids in herpetic, voriconasole or amphotericin-B in mycotic, and topical-triple-therapy (diamidine, biguanid and antibiotics) in acanthamoeba keratitis...
August 2017: Orvosi Hetilap
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