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https://www.readbyqxmd.com/read/28350996/quality-measures-of-the-population-based-finnish-cancer-registry-indicate-sound-data-quality-for-solid-malignant-tumours
#1
Maarit K Leinonen, Joonas Miettinen, Sanna Heikkinen, Janne Pitkäniemi, Nea Malila
BACKGROUND: The Finnish Cancer Registry (FCR) has collected population-based data on cancer incidence for scientific research and statistical purposes since 1953. Our aim was to provide a comprehensive quality assessment of the current cancer registry data in Finland. METHODS: We used established quantitative and semi-quantitative techniques to address four main dimensions of data quality: completeness, comparability, validity and timeliness for the period 1953-2013, with a special focus on cancers diagnosed in 2009-2013...
March 25, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28350949/state-of-the-art-in-degenerative-cervical-myelopathy-an-update-on-current-clinical-evidence
#2
Jefferson R Wilson, Lindsay A Tetreault, Jun Kim, Mohammed F Shamji, James S Harrop, Thomas Mroz, Samuel Cho, Michael G Fehlings
Degenerative cervical myelopathy (DCM) is a common cause of spinal cord dysfunction that confronts clinicians on a daily basis. Research performed over the past few decades has provided improved insight into the diagnosis, evaluation, and treatment of this disorder. We aim to provide clinicians with an update regarding the state of the art in DCM, focusing on more recent research pertaining to pathophysiology, natural history, treatment, consideration of the minimally symptomatic patient, surgical outcome prediction, and outcome measurement...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28350935/screening-for-celiac-disease-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#3
Roger Chou, Christina Bougatsos, Ian Blazina, Katherine Mackey, Sara Grusing, Shelley Selph
Importance: Silent or subclinical celiac disease may result in potentially avoidable adverse health consequences. Objective: To review the evidence on benefits and harms of screening for celiac disease in asymptomatic adults, adolescents, and children 3 years and older for the US Preventive Services Task Force. Data Sources: Ovid MEDLINE, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews, searched to June 14, 2016...
March 28, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28350894/assessing-the-amount-of-spontaneous-real-world-spoken-language-in-aphasia-validation-of-two-methods
#4
Michelle M Haddad, Edward Taub, Gitendra Uswatte, Margaret L Johnson, Victor W Mark, Ameen Barghi, Ezekiel Byrom, Xiaohua Zhou, Christina M Rodriguez
Purpose: The purpose of this article is to present the results of a study evaluating the psychometric properties of 2 new measures that exclusively assess the amount of real-world spoken language in patients with aphasia. Method: Forty individuals with aphasia were evaluated on several measures of spoken language in real-world settings. The Verbal Activity Log (VAL; Johnson et al., 2014) has participants, aided by caregivers, indicate current amount and quality of real-world spoken language compared with before stroke...
March 28, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28350809/the-impact-of-a-family-skills-training-intervention-among-burmese-migrant-families-in-thailand-a-randomized-controlled-trial
#5
Eve S Puffer, Jeannie Annan, Amanda L Sim, Carmel Salhi, Theresa S Betancourt
OBJECTIVE: To conduct a randomized controlled trial assessing the impact of a family-based intervention delivered to Burmese migrant families displaced in Thailand on parenting and family functioning. PARTICIPANTS AND PROCEDURES: Participants included 479 Burmese migrant families from 20 communities in Thailand. Families, including 513 caregivers and 479 children aged 7 to 15 years, were randomized to treatment and waitlist control groups. The treatment group received a 12-session family-based intervention delivered to groups of families by lay facilitators...
2017: PloS One
https://www.readbyqxmd.com/read/28350759/resveratrol-supplementation-reduces-pain-experience-by-postmenopausal-women
#6
Rachel H X Wong, Hamish M Evans, Peter R C Howe
OBJECTIVE: Pain is a common complaint among postmenopausal women. It has been postulated that vascular dysfunction caused by estrogen decline at menopause plays a key role in the initiation and progression of degradative joint disease, namely age-related osteoarthritis. We evaluated whether supplementation with resveratrol, a phytoestrogen, could improve aspects of well-being such as chronic pain that is commonly experienced by postmenopausal women. METHODS: A 14-week randomized, double-blind, placebo-controlled intervention with trans-resveratrol (75 mg, twice daily) was conducted in 80 healthy postmenopausal women...
March 27, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28350746/perceived-stress-as-a-risk-factor-for-dyspepsia-a-register-based-cohort-study
#7
Ulrik Deding, Christian Torp-Pedersen, Henrik Bøggild
OBJECTIVE: Dyspepsia is a common condition and has a huge impact on quality of life and working capacity, but its causes are not well understood. An association between stress and dyspepsia has been debated for decades, but the issue has not been resolved. We examined the 3-year risk of redeeming a proton-pump inhibitor or an H2-receptor antagonist as a proxy of dyspepsia according to the level of perceived stress. PARTICIPANTS AND METHODS: Perceived stress was measured in a general health survey of 16 124 Danes aged older than 16 years of age in 2010 using Cohen's Perceived Stress Scale...
May 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28350639/measuring-the-cost-of-the-patient-centered-medical-home-a-cost-accounting-approach
#8
Robert D Lieberthal, Colleen Payton, Mona Sarfaty, George Valko
To explore the cost for individual practices to become more patient-centered, we inventoried and calculated the cost of costly activities involved in implementing the Patient-Centered Medical Home (PCMH) as defined by the National Committee for Quality Assurance. There were 3 key findings. The cost of each PCMH-related clinical activity can be classified in 1 of 3 major categories. Cost offsets can be used to defray part of the cost recognition. The cost of PCMH transformation varied by practice with no clear level or pattern of costs...
March 27, 2017: Journal of Ambulatory Care Management
https://www.readbyqxmd.com/read/28350455/model-based-classification-for-digital-pcr-your-umbrella-for-rain
#9
Bart K M Jacobs, Els Goetghebeur, Jo Vandesompele, Ariane De Ganck, Nele Nijs, Anneleen Beckers, Nina Papazova, Nancy Hélène C J Roosens, Lieven Clement
Standard data analysis pipelines for digital PCR estimate the concentration of a target nucleic acid by digitizing the end-point fluorescence of the parallel micro-PCR reactions using an automated hard threshold. While it is known that misclassification has a major impact on the concentration estimate and substantially reduces accuracy, the uncertainty of this classification is typically ignored. We introduce a model-based clustering method to estimate the probability that the target is present (absent) in a partition conditional on its observed fluorescence and the distributional shape in no template control samples...
March 28, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28346851/aquatic-therapy-for-people-with-lymphedema-a-systematic-review-and-meta-analysis
#10
Wai Yeung, Adam I Semciw
BACKGROUND: Aquatic therapy has several proposed benefits for people with lymphedema. A systematic review of the evidence for aquatic therapy in lymphedema management has not been conducted. METHOD AND RESULTS: Systematic review and meta-analysis were conducted. Five electronic databases were searched to identify randomized controlled trials (RCTs) of people with lymphedema, which compared aquatic therapy with other lymphedema interventions. Qualitative analysis was undertaken where quantitative analysis was not possible...
March 27, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28346808/patient-reported-outcomes-1-year-after-immediate-breast-reconstruction-results-of-the-mastectomy-reconstruction-outcomes-consortium-study
#11
Andrea L Pusic, Evan Matros, Neil Fine, Edward Buchel, Gayle M Gordillo, Jennifer B Hamill, Hyungjin M Kim, Ji Qi, Claudia Albornoz, Anne F Klassen, Edwin G Wilkins
Purpose The goals of immediate postmastectomy breast reconstruction are to minimize deformity and optimize quality of life as perceived by patients. We prospectively evaluated patient-reported outcomes (PROs) in women undergoing immediate implant-based or autologous reconstruction. Methods Women undergoing immediate postmastectomy reconstruction for invasive cancer and/or carcinoma in situ were enrolled at 11 sites. Women underwent implant-based or autologous tissue reconstruction. Patients completed the BREAST-Q, a condition-specific PRO measure for breast surgery patients, and Patient-Reported Outcomes Measurement Information System-29, a generic PRO measure, before and 1 year after surgery...
March 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28346770/a-core-outcome-set-for-localised-prostate-cancer-effectiveness-trials
#12
Steven MacLennan, Paula R Williamson, Hanneke Bekema, Marion Campbell, Craig Ramsay, James N'Dow, Sara MacLennan, Luke Vale, Philipp Dahm, Nicolas Mottet, Thomas Lam, Paul Abel, Hashim U Ahmed, Gary Akehurst, Robert Almquist, Karl Beck, David Budd, Steven Canfield, James Catto, Philip Cornford, William Cross, Alexander Ewen, Judith Grant, Rakesh Heer, David Hurst, Rob Jones, Roger Kockelbergh, Andrew Mackie, Graham MacDonald, Alan McNeill, Malcolm Mason, Sam McClinton, Duncan McLaren, Hugh Mostafid, Ian Pearce, Linda Pennet, Justine Royle, Hans Schreuder, Grant D Stewart, Henk van der Poel, Kevin Wardlaw, Thomas Wiegel
OBJECTIVE: To develop a core outcome set (COS) applicable for effectiveness trials of all interventions for localised prostate cancer. BACKGROUND: Many treatments exist for localised prostate cancer, although it is unclear which offers the optimal therapeutic ratio. This is confounded by inconsistencies in the selection, definition, measurement and reporting of outcomes in clinical trials. SUBJECTS AND METHODS: A list of 79 outcomes was derived from a systematic review of published localised prostate cancer effectiveness studies and semi-structured interviews with 15 prostate cancer patients...
March 27, 2017: BJU International
https://www.readbyqxmd.com/read/28346754/commentary-what-makes-a-life-go-well-moral-functioning-and-quality-of-life-measurement-in-neurodevelopmental-disorders-reflections-on-jonsson-et%C3%A2-al-2017
#13
Ilina Singh
Jonsson et al.'s excellent review of the literature on quality of life (QoL) and childhood mental and behavioural disorders (Jonsson et al., ) highlights the need for studies that utilise child self-reported QoL, in contrast to parent or proxy QoL measures, and further challenges the field to develop QoL measures that 'put the child's own views and priorities first'.
April 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28346652/treatment-success-with-titratable-thermoplastic-mandibular-advancement-devices-for-obstructive-sleep-apnea-a-comparison-of-patient-characteristics
#14
Tang-Chuan Wang, Yung-An Tsou, Yi-Fan Wu, Chia-Chang Huang, Wesley Wen-Yang Lin, Yu-Fen Li, Michael Yuan-Chien Chen, Chih-Jaan Tai, Ming-Hsui Tsai
A titratable thermoplastic mandibular advancement device (MAD) is clearly an effective treatment option in some patients with obstructive sleep apnea (OSA). Determining which patients may be more likely to respond to treatment with thermoplastic MADs and to adhere to treatment would be of obvious clinical relevance. This was an experimental descriptive study (N = 60). Patients with OSA were instructed to wear a titratable thermoplastic MAD for 3 months. Treatment success was defined as a ≥50% reduction from baseline in the apnea-hypopnea index (AHI) or AHI <10 when wearing MAD...
March 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28346563/delivery-of-nutritious-meals-to-elderly-receiving-home-care-feasibility-and-effectiveness
#15
K F M Denissen, L M J Janssen, S J P M Eussen, M C J M van Dongen, N E G Wijckmans, N D M van Deurse, P C Dagnelie
BACKGROUND/OBJECTIVES: Elderly with functional disabilities are at increased risk of inadequate dietary intake. Little is known about the effectiveness of interventions aimed at improving their dietary intake and nutritional status, nor about the determinants of successful implementation. We performed a feasibility study to evaluate the implementation and effectiveness of a home delivery service providing nutritious meals. DESIGN: Quasi-experimental, with participants allocated to treatment group based on municipality of residence...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28346541/quality-of-life-and-objective-outcome-assessment-in-women-with-tape-division-after-surgery-for-stress-urinary-incontinence
#16
Daniela Ulrich, Vesna Bjelic-Radisic, Anna Höllein, Gerda Trutnovsky, Karl Tamussino, Thomas Aigmüller
BACKGROUND: Midurethral tapes may cause long-term complications such as voiding dysfunction, groin pain, de novo urgency or mesh erosion, which necessitate a reoperation. There is a paucity of data regarding health related quality of life in patients undergoing tape removal. The aim of the study was to evaluate quality of life (QoL) and objective outcome after midurethral tape division or excision. METHODS: All patients who underwent a midurethral tape division for voiding difficulties, pain or therapy resistant de novo overactive bladder between 1999 and 2014 were invited for follow-up...
2017: PloS One
https://www.readbyqxmd.com/read/28346330/differentiation-of-impaired-from-preserved-hemodynamics-in-patients-with-fontan-circulation-using-real-time-phase-velocity-cardiovascular-magnetic-resonance
#17
Hermann Körperich, Katja Müller, Peter Barth, Jürgen Gieseke, Nikolaus Haas, Ingram Schulze-Neick, Wolfgang Burchert, Deniz Kececioglu, Kai T Laser
PURPOSE: Progressive impairment of hemodynamics in patients with Fontan circulation is common, multifactorial, and associated with decreased quality of life and increased morbidity. We sought to assess hemodynamic differences between patients with preserved (preserved Fontans) and those with impaired circulation (impaired Fontans) after pulmonary vasodilation using oxygen and under forced breathing conditions. MATERIALS AND METHODS: Real-time phase-contrast cardiovascular magnetic resonance was performed using non-ECG triggered echo-planar imaging (temporal resolution=24 to 28 ms) in the ascending aorta (AAo) and superior vena cava (SVC)/inferior vena cava (IVC) on room air, after 100% oxygen inhalation (4 L/min; 10 min) and on forced breathing in 29 Fontan patients (17...
March 24, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28346315/the-effects-of-10-weeks-integrated-neuromuscular-training-on-fundamental-movement-skills-and-physical-self-efficacy-in-6-7-year-old-children
#18
Michael J Duncan, Emma L J Eyre, Samuel W Oxford
Integrated neuromuscular training (INT) has been suggested as an effective means to enhance athletic potential in children. However, few studies have reported the effects of school based INT programs. This study examined the effect of INT on process and product fundamental movement skill measures and physical self-efficacy in 6-7 year old children. Ninety-four children from 2 primary schools were randomised into either a 10 week INT program or a control group CON (n =41) group. Results indicated significantly greater increases in process FMS scores in INT vs CON (P = 0...
March 23, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28346278/effects-of-myopic-orthokeratology-on-visual-performance-and-optical-quality
#19
Guihua Liu, Zhi Chen, Feng Xue, Jing Li, Mi Tian, Xingtao Zhou, Ruihua Wei
OBJECTIVES: To analyze the changes in visual performance and optical quality after orthokeratology (ortho-k) treatment and its correlation with the magnitude of lens decentration and the diameter of treatment zone (TxZ). METHODS: A prospective study was conducted in 27 eyes of 27 patients wearing ortho-k contact lens. Area under log contrast sensitivity function (AULCSF), modulation transfer function cutoff values (MTFcutoff), Strehl ratio (SR), and objective scattering index (OSI) were measured and compared before and 1 month after ortho-k lens treatment...
March 24, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28346276/comparison-of-noncontact-specular-and-confocal-microscopy-for-evaluation-of-corneal-endothelium
#20
Jianyan Huang, Jyotsna Maram, Tudor C Tepelus, Srinivas R Sadda, Vikas Chopra, Olivia L Lee
PURPOSE: To compare endothelial cell analysis obtained by noncontact specular and confocal microscopy, using the Konan NSP-9900 and Nidek ConfoScan4 systems, respectively. METHODS: Three groups including 70 healthy eyes, 49 eyes with Fuchs endothelial corneal dystrophy (FECD), and 78 eyes with glaucoma were examined with both the Konan NSP-9900 specular microscope and the Nidek ConfocScan4 confocal microscope. Certified graders at the Doheny Image Reading Center compared corneal endothelial images from both instruments side by side to assess image quality...
March 24, 2017: Eye & Contact Lens
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