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Yael Garten, Adrien Coulet, Russ B Altman
The biomedical literature holds our understanding of pharmacogenomics, but it is dispersed across many journals. In order to integrate our knowledge, connect important facts across publications and generate new hypotheses we must organize and encode the contents of the literature. By creating databases of structured pharmocogenomic knowledge, we can make the value of the literature much greater than the sum of the individual reports. We can, for example, generate candidate gene lists or interpret surprising hits in genome-wide association studies...
October 2010: Pharmacogenomics
J J Luykx, M P M Boks, A P R Terwindt, S Bakker, R S Kahn, R A Ophoff
We aimed to get a comprehensive insight into the genetic evidence supporting the role of GSK3beta in bipolar disorder (BD). Using broad searches in NCBI's PubMed and the Genetic Association Database we looked for association, whole-genome linkage, genome-wide association, gene expression, pharmocogenomic, epigenetic, cytogenetic, and mouse model studies performed for BD until July 2009. Per gene, we rated the degree of converging evidence across these types of genetic studies. The genes most consistently associated with BD in the genetic studies we reviewed were GSK3beta , GRK3, 5-HTTLPR, GRIN3, COMT, and GLUR3...
June 2010: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Jean-Charles Hoda, Wenli Gu, Marc Friedli, Hilary A Phillips, Sonia Bertrand, Stylianos E Antonarakis, David Goudie, Richard Roberts, Ingrid E Scheffer, Carla Marini, Jayesh Patel, Samuel F Berkovic, John C Mulley, Ortrud K Steinlein, Daniel Bertrand
Certain mutations in specific parts of the neuronal nicotinic acetylcholine receptor (nAChR) subunit genes CHRNA4, CHRNB2, and probably CHRNA2, can cause autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). All but one of the known causative mutations are located in the second transmembrane region (TM2), which serves as the major ion poreforming domain of the receptor. Functional characterization of these ADNFLE mutations has shown that although each mutant exhibits specific properties, they all confer a gain of function with increased sensitivity to acetylcholine...
August 2008: Molecular Pharmacology
Allan E Rettie, Guoying Tai
Warfarin, a coumarin anticoagulant, is used worldwide for the treatment and prevention of thromboembolic disease. Warfarin therapy, however, can be difficult to manage because of the drug's narrow therapeutic index and the wide interindividual variability in patient response. It is now clear that genetic polymorphisms in genes influencing metabolism (CYP2C9) and pharmacodynamic response (VKORC1) are strongly associated with warfarin responsiveness. Optimal warfarin dosing in turn drives other positive anticoagulation-related outcomes...
August 2006: Molecular Interventions
Robert C Bast, Gordon B Mills
No abstract text is available yet for this article.
January 2003: Gynecologic Oncology
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