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Systematic reviews and acute bronchiolitis

Patricia Green, Stephen C Aronoff, Michael DelVecchio
Background. Acute bronchiolitis infection during infancy is associated with an increased risk of asthma later in life. The objective of this study was to determine if inhaled steroids are effective in preventing the development of recurrent wheeze or asthma following acute bronchiolitis. Methods. Multiple databases and bibliographies of selected references were searched. Inclusion required (a) a randomized controlled trial of inhaled steroids and control group, (b) at least 2 weeks duration of therapy started during the acute phase of disease, and (c) identification of the rate of recurrent wheeze or asthma at least 6 months after therapy...
2015: Global Pediatric Health
Catherine H Miele, Kristin Schwab, Rajeev Saggar, Erin Duffy, David Elashoff, Chi-Hong Tseng, Sam Weigt, Deepshikha Charan, Fereidoun Abtin, Jimmy Johannes, Ariss Derhovanessian, Jeffrey Conklin, Kevin Ghassemi, Dinesh Khanna, Osama Siddiqui, Abbas Ardehali, Curtis Hunter, Murray Kwon, Reshma Biniwale, Michelle Lo, Elizabeth Volkmann, David Torres Barba, John A Belperio, David Sayah, Thomas Mahrer, Daniel E Furst, Suzanne Kafaja, Philip Clements, Michael Shino, Aric Gregson, Bernard Kubak, Joseph P Lynch, David Ross, Rajan Saggar
RATIONALE: Consideration of lung transplantation in patients with systemic sclerosis (SSc) remains guarded, often due to the concern for esophageal dysfunction and the associated potential for allograft injury and suboptimal post-lung transplantation outcomes. OBJECTIVES: The purpose of this study was to systematically report our single-center experience regarding lung transplantation in the setting of SSc, with a particular focus on esophageal dysfunction. METHODS: We retrospectively reviewed all lung transplants at our center from January 1, 2000 through August 31, 2012 (n = 562), comparing the SSc group (n = 35) to the following lung transplant diagnostic subsets: all non-SSc (n = 527), non-SSc diffuse fibrotic lung disease (n = 264), and a non-SSc matched group (n = 109)...
June 2016: Annals of the American Thoracic Society
(no author information available yet)
No abstract text is available yet for this article.
April 2016: Pediatrics
Chin Maguire, Hannah Cantrill, Daniel Hind, Mike Bradburn, Mark L Everard
BACKGROUND: Acute bronchiolitis is the commonest cause of hospitalisation in infancy. Currently management consists of supportive care and oxygen. A Cochrane review concluded that, "nebulised 3 % saline may significantly reduce the length of hospital stay". We conducted a systematic review of controlled trials of nebulised hypertonic saline (HS) for infants hospitalised with primary acute bronchiolitis. METHODS: Searches to January 2015 involved: Cochrane Central Register of Controlled Trials; Ovid MEDLINE; Embase; Google Scholar; Web of Science; and, a variety of trials registers...
2015: BMC Pulmonary Medicine
Linjie Zhang, Raúl A Mendoza-Sassi, Terry P Klassen, Claire Wainwright
BACKGROUND AND OBJECTIVE: The mainstay of treatment for acute bronchiolitis remains supportive care. The objective of this study was to assess the efficacy and safety of nebulized hypertonic saline (HS) in infants with acute bronchiolitis. METHODS: Data sources included PubMed and the Virtual Health Library of the Latin American and Caribbean Center on Health Sciences Information up to May 2015. Studies selected were randomized or quasi-randomized controlled trials comparing nebulized HS with 0...
October 2015: Pediatrics
Carlos E Rodriguez-Martinez, Monica P Sossa-Briceño, Ranniery Acuña-Cordero
RATIONALE, AIMS AND OBJECTIVES: Recently, in an attempt to reduce variability in clinical practice and produce better results for patients, several clinical practice guidelines (CPGs) for the appropriate diagnosis and management of bronchiolitis in infants have been developed. However, the quality of available CPGs for bronchiolitis management has not yet been systematically evaluated. The aim of this study was to assess the quality of acute viral bronchiolitis CPGs. METHOD: We performed a systematic and exhaustive search of CPGs on bronchiolitis published from 2000 to 2014...
September 8, 2015: Journal of Evaluation in Clinical Practice
Mark L Everard, Daniel Hind, Kelechi Ugonna, Jennifer Freeman, Mike Bradburn, Simon Dixon, Chin Maguire, Hannah Cantrill, John Alexander, Warren Lenney, Paul McNamara, Heather Elphick, Philip Aj Chetcuti, Eduardo F Moya, Colin Powell, Jonathan P Garside, Lavleen Kumar Chadha, Matthew Kurian, Ravinderjit S Lehal, Peter I MacFarlane, Cindy L Cooper, Elizabeth Cross
BACKGROUND: Acute bronchiolitis is the most common cause of hospitalisation in infancy. Supportive care and oxygen are the cornerstones of management. A Cochrane review concluded that the use of nebulised 3% hypertonic saline (HS) may significantly reduce the duration of hospitalisation. OBJECTIVE: To test the hypothesis that HS reduces the time to when infants were assessed as being fit for discharge, defined as in air with saturations of > 92% for 6 hours, by 25%...
August 2015: Health Technology Assessment: HTA
Robert G Badgett, Mohinder Vindhyal, Jason T Stirnaman, C Michael Gibson, Rim Halaby
No abstract text is available yet for this article.
August 2015: JAMA Pediatrics
Jose A Castro-Rodriguez, Carlos E Rodriguez-Martinez, Monica P Sossa-Briceño
Bronchiolitis is the most common cause of hospitalization among infants during the first 12 months of life, with high direct and indirect cost for health system and families. Different treatment approaches co-exist worldwide resulting in many drugs prescribed, without any proven benefit. Twenty systematic reviews of randomized clinical trials (SRCTs) on management of acute bronchiolitis in children were retrieved through 5 databases and their methodological quality was determined using an AMSTAR tool. Epinephrine showed impact only in short-term outcomes among outpatients (reduced admission at day 1 and improved the clinical score in the first 2 hours, compared to placebo) and inpatients (decreased length of stay (LOS) and improved saturation only in the first 2 hours, compared to nebulized salbutamol, but with high heterogeneity)...
September 2015: Paediatric Respiratory Reviews
B Sterling, E Bosdure, N Stremler-Le Bel, B Chabrol, J-C Dubus
Every winter, numerous infants are hospitalized for acute bronchiolitis. The severity criteria and symptomatic treatment are well known, with chest physiotherapy codified in 2000 by the French Health Authority (HAS) consensus conference (with techniques varying from one country to another) and becoming nearly systematic for the treatment of bronchial obstruction in infants. However, is this treatment really effective and legitimate for acute bronchiolitis? The objective of this study was to review the main studies on this subject...
January 2015: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Lisa Hartling, Ben Vandermeer, Ricardo M Fernandes
BACKGROUND: The Cochrane Collaboration has been at the forefront of developing methods for knowledge synthesis internationally. OBJECTIVES: We discuss three approaches to synthesize evidence for healthcare interventions: systematic reviews (SRs), overviews of reviews and comparative effectiveness reviews. METHODS: We illustrate these approaches with examples from knowledge syntheses on interventions for bronchiolitis, a common acute paediatric condition...
June 2014: Evidence-based Child Health: a Cochrane Review Journal
Ricardo M Fernandes, Marta Oleszczuk, Charles R Woods, Brian H Rowe, Christopher J Cates, Lisa Hartling
BACKGROUND: Acute respiratory conditions are a leading cause of childhood morbidity and mortality. Corticosteroids are effective and established treatments in some acute respiratory infections (e.g. croup) and asthma exacerbations; however, their role is controversial in other conditions owing to inconsistent effectiveness or safety concerns (e.g. bronchiolitis, acute wheeze). OBJECTIVES: To examine clinically relevant short-term safety outcomes related to acute single or recurrent systemic short-term (<2 weeks) corticosteroid use based on systematic reviews of acute respiratory conditions...
September 2014: Evidence-based Child Health: a Cochrane Review Journal
Shawn Ralston, Allison Comick, Elizabeth Nichols, Devin Parker, Patricia Lanter
BACKGROUND: Bronchiolitis causes nearly 20% of all acute care hospitalizations for young children in the United States. Unnecessary testing and medication for infants with bronchiolitis contribute to cost without improving outcomes. OBJECTIVES: The goal of this study was to systematically review the quality improvement (QI) literature on inpatient bronchiolitis and to propose benchmarks for reducing unnecessary care. METHODS: Assisted by a medical librarian, we searched Medline, Cumulative Index to Nursing and Allied Health Literature, and the Cochrane Library...
September 2014: Pediatrics
Ariel Bardach, Lucila Rey-Ares, María Luisa Cafferata, Gabriela Cormick, Marina Romano, Silvina Ruvinsky, Vilma Savy
Respiratory syncytial virus (RSV) is a frequent cause of acute respiratory infection and the most common cause of bronchiolitis in infants. The aim of this systematic review and meta-analysis was to obtain a comprehensive epidemiological picture of the data available on disease burden, surveillance, and use of resources in Latin America. Pooled estimates are useful for cross-country comparisons. Data from published studies reporting patients with probable or confirmed RSV infection in medical databases and gray literature were included from 74 studies selected from the 291 initially identified...
March 2014: Reviews in Medical Virology
Matthew Thompson, Talley A Vodicka, Peter S Blair, David I Buckley, Carl Heneghan, Alastair D Hay
OBJECTIVE: To determine the expected duration of symptoms of common respiratory tract infections in children in primary and emergency care. DESIGN: Systematic review of existing literature to determine durations of symptoms of earache, sore throat, cough (including acute cough, bronchiolitis, and croup), and common cold in children. DATA SOURCES: PubMed, DARE, and CINAHL (all to July 2012). ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Randomised controlled trials or observational studies of children with acute respiratory tract infections in primary care or emergency settings in high income countries who received either a control treatment or a placebo or over-the-counter treatment...
2013: BMJ: British Medical Journal
Mona Sharifi, Shanthi Krishanswami, Melissa L McPheeters
PURPOSE: To identify and assess billing, procedural, or diagnosis code, or pharmacy claim-based algorithms used to identify acute bronchospasm in administrative and claims databases. METHODS: We searched the MEDLINE database from 1991 to September 2012 using controlled vocabulary and key terms related to bronchospasm, wheeze and acute asthma. We also searched the reference lists of included studies. Two investigators independently assessed the full text of studies against pre-determined inclusion criteria...
December 30, 2013: Vaccine
Luit Penninga, Christian H Møller, Elisabeth I Penninga, Martin Iversen, Christian Gluud, Daniel A Steinbrüchel
BACKGROUND: Lung transplantation has become a valuable and well-accepted treatment option for most end-stage lung diseases. Lung transplant recipients are at risk of transplanted organ rejection, and life-long immunosuppression is necessary. Clear evidence is essential to identify an optimal, safe and effective immunosuppressive treatment strategy for lung transplant recipients. Consensus has not yet been achieved concerning use of immunosuppressive antibodies against T-cells for induction following lung transplantation...
2013: Cochrane Database of Systematic Reviews
Jolita Bekhof, Roelien Reimink, Paul L P Brand
BACKGROUND: A reliable, valid, and easy-to-use assessment of the degree of wheeze-associated dyspnoea is important to provide individualised treatment for children with acute asthma, wheeze or bronchiolitis. OBJECTIVE: To assess validity, reliability, and utility of all available paediatric dyspnoea scores. METHODS: Systematic review. We searched Pubmed, Cochrane library, National Guideline Clearinghouse, Embase and Cinahl for eligible studies...
March 2014: Paediatric Respiratory Reviews
Wan-Sheng Peng, Xin Chen, Xiao-Yun Yang, En-Mei Liu
Infants often develop reactive airway diseases subsequent to respiratory syncytial virus (RSV) bronchiolitis. Cysteinyl leukotrienes (cysLTs), a class of lipid mediators that have been implicated in the pathogenesis of allergic rhinitis and asthma, are released during RSV infection, thereby contributing to the pathogenic changes in airway inflammation. Many pediatric patients, especially those of very young age, continue to have recurrent episodes of lower airway obstruction after bronchiolitis treatment. This study was to systematically review and assessed the efficacy of montelukast for preventing wheezing in patients with post-bronchiolitis...
March 2014: Pediatric Allergy and Immunology
J Dayre McNally, Margaret Sampson, Loren A Matheson, Brian Hutton, Julian Little
BACKGROUND: A number of small studies have suggested a relationship between vitamin D status and severe acute lower respiratory tract infection (ALRI), including RSV-bronchiolitis. The objective of this study was to evaluate the relationship between vitamin D receptor (VDR) polymorphism and severe RSV-bronchiolitis through a systemic literature review and meta-analysis. METHODS: A comprehensive electronic literature search was conducted to identify all studies published before January 2013...
August 2014: Pediatric Pulmonology
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