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https://www.readbyqxmd.com/read/28239753/six-minute-walk-test-in-evaluation-of-children-with-pulmonary-arterial-hypertension
#1
Malgorzata Zuk, Anna Migdal, Dorota Jagiellowicz-Kowalska, Katarzyna Mazurkiewicz, Anna Sadel-Wieczorek, Grazyna Brzezinska-Rajszys
Six-minute walk test (6MWT) is a submaximal exercise test applied for evaluation of adults with pulmonary arterial hypertension (PAH). It was widely used as an endpoint in the clinical trials. The aim of the study was to assess the usefulness of 6MWT in management of children with PAH and to establish correlations with other clinical features. 164 6MWT were performed in 15 children between 5 and 18 years with PAH confirmed by right heart catheterization (102 in patients with shunt, 62 without shunt). Distance in 6MWT (6MWD)-% of predicted for age and gender, desaturation at the maximum effort, peak heart rate (HR)-% of maximal HR, were compared to the level of NTproBNP, WHO-FC, echocardiography parameters, and events of PAH treatment intensification...
February 27, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28239551/genome-wide-chromatin-accessibility-dna-methylation-and-gene-expression-analysis-of-histone-deacetylase-inhibition-in-triple-negative-breast-cancer
#2
Matias A Bustos, Matthew P Salomon, Nellie Nelson, Sandy C Hsu, Maggie L DiNome, Dave S B Hoon, Diego M Marzese
Triple-negative breast cancer (TNBC), especially the subset with a basal phenotype, represents the most aggressive subtype of breast cancer. Unlike other solid tumors, TNBCs harbor a low number of driver mutations. Conversely, we and others have demonstrated a significant impact of epigenetic alterations, including DNA methylation and histone post-translational modifications, affecting TNBCs. Due to the promising results in pre-clinical studies, histone deacetylase inhibitors (HDACi) are currently being tested in several clinical trials for breast cancer and other solid tumors...
June 2017: Genomics Data
https://www.readbyqxmd.com/read/28238789/the-significance-of-the-trial-outcome-was-associated-with-publication-rate-and-time-to-publication
#3
Seung Yeon Song, Dong-Hoe Koo, Sun-Young Jung, Won Ku Kang, Eun Young Kim
OBJECTIVE: This study aims to comprehensively assess the publication of clinical trial results and factors associated with their publication. STUDY DESIGN AND SETTING: Phase II and phase III trials of advanced breast cancer registered on ClinicalTrials.gov between October 1, 2000, and September 30, 2012 were identified. Publications were searched by using PubMed and reviewing those listed on the registry site. The main outcomes were publication rate, public availability of results, and time to publication...
February 24, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28238748/can-we-predict-fall-asthma-exacerbations-validation-of-the-seasonal-asthma-exacerbation-index
#4
Heather E Hoch, Agustin Calatroni, Joseph B West, Andrew H Liu, Peter J Gergen, Rebecca S Gruchalla, Khurana G K Hershey, Carolyn M Kercsmar, Haejin Kim, Carin I Lamm, Melanie M Makhija, Herman E Mitchell, Stephen J Teach, Jeremy J Wildfire, William W Busse, Stanley J Szefler
BACKGROUND: A Seasonal Asthma Exacerbation Predictive Index (saEPI) was previously reported based on two prior NIAID Inner City Asthma Consortium trials. OBJECTIVE: We sought to validate the saEPI in a separate trial designed to prevent fall exacerbations with omalizumab therapy. METHODS: The saEPI and its components were analyzed to characterize those who had an asthma exacerbation during the PROSE (Preventative Omalizumab or Step-Up Therapy for Fall Exacerbations) study...
February 23, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28238465/factors-related-to-client-satisfaction-with-methadone-maintenance-treatment-in-china
#5
Li Li, W Scott Comulada, Chunqing Lin, Julie Hsieh, Sitong Luo, Zunyou Wu
BACKGROUND: This study examined clients' treatment satisfaction with the services provided by methadone maintenance treatment (MMT) in China and explored relevant factors that are directly or indirectly associated with treatment satisfaction. METHODS: The study used baseline data from a randomized controlled trial conducted among 2,448 clients from 68 MMT clinics in five provinces of China. The participants reported their demographic characteristics, treatment-related factors, depressive symptoms, treatment progression, counseling rapport, and treatment satisfaction...
February 23, 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28237979/targeting-immunity-in-end-stage-renal-disease
#6
Ivano Baragetti, Basset El Essawy, Paolo Fiorina
BACKGROUND: Despite the stable incidence of end-stage renal disease (ESRD), it continues to be associated with an unacceptably high cardiovascular risk. SUMMARY: ESRD is characterized by enhanced oxidative stress and severe inflammation, which boost cardiovascular risk, thus increasing cardiovascular-associated mortality rate. While substantial effort has been made in the technological innovation of dialytic techniques, few significant advances have been made to reduce inflammation in patients with ESRD...
February 25, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28237955/advance-care-planning-uptake-among-patients-with-severe-lung-disease-a-randomised-patient-preference-trial-of-a-nurse-led-facilitated-advance-care-planning-intervention
#7
Craig Sinclair, Kirsten Anne Auret, Sharon Frances Evans, Fiona Williamson, Siobhan Dormer, Anne Wilkinson, Kim Greeve, Audrey Koay, Dot Price, Fraser Brims
OBJECTIVE: Advance care planning (ACP) clarifies goals for future care if a patient becomes unable to communicate their own preferences. However, ACP uptake is low, with discussions often occurring late. This study assessed whether a systematic nurse-led ACP intervention increases ACP in patients with advanced respiratory disease. DESIGN: A multicentre open-label randomised controlled trial with preference arm. SETTING: Metropolitan teaching hospital and a rural healthcare network...
February 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28237867/exploratory-analysis-of-biomarkers-associated-with-clinical-outcomes-from-the-study-of-lenvatinib-in-differentiated-cancer-of-the-thyroid
#8
Makoto Tahara, Martin Schlumberger, Rossella Elisei, Mouhammed Amir Habra, Naomi Kiyota, Ralf Paschke, Corina E Dutcus, Taro Hihara, Shannon McGrath, Mark Matijevic, Tadashi Kadowaki, Yasuhiro Funahashi, Steven I Sherman
BACKGROUND: Lenvatinib significantly prolonged progression-free survival (PFS) versus placebo in the phase III Study of (E7080) LEnvatinib in differentiated Cancer of the Thyroid (SELECT) of patients with radioiodine-refractory differentiated thyroid cancer. This exploratory analysis investigated potential predictive biomarkers of lenvatinib efficacy and target engagement. PATIENTS AND METHODS: Circulating cytokine/angiogenic factors (CAFs) in blood samples collected at baseline and throughout treatment were analysed from patients randomised to receive lenvatinib or placebo from August 5, 2011 to October 4, 2012...
February 23, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28237759/the-psychometric-validity-of-the-center-for-epidemiological-studies-depression-scale-ces-d-in-first-episode-schizophrenia-spectrum
#9
Sarah E Herniman, Kelly A Allott, Eóin Killackey, Robert Hester, Sue M Cotton
Depressive pathology is common in first-episode schizophrenia spectrum disorders (FES), and is frequently assessed using the Center for Epidemiological Studies - Depression Scale (CES-D), an instrument designed for use in community samples. Despite its widespread use, no prior study has examined the psychometric validity of the CES-D in assessing depressive pathology in FES. The aim of this study was to examine the psychometric validity of the CES-D in FES. This study involved secondary analysis of baseline data from a single blind, randomized controlled trial of vocational intervention for individuals with FES (N=91; age range: 15-25 years)...
February 11, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28237746/cognitive-behavioral-treatment-for-depressed-patients-with-alzheimer-s-disease-an-open-trial
#10
José María García-Alberca
BACKGROUND: Depression has a high prevalence among patients with Alzheimer's disease, and it has a significant negative impact on their functioning. However, despite its significant impact and challenge, few treatment outcomes data are available to guide clinical care of depression among this population. We developed a cognitive-behavioral intervention to persons with AD. In this paper, we describe the intervention and results of an open trial evaluating its feasibility and utility. SETTING: Dementia Unit...
February 14, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28237693/event-related-theta-oscillatory-substrates-for-facilitation-and-interference-effects-of-negative-emotion-on-children-s-cognition
#11
Zhongqing Jiang, Allison C Waters, Ying Liu, Wenhui Li, Lizhu Yang
We investigated the brain oscillatory contribution to emotion-cognition interaction in young children. Five-year-old participants (n=27) underwent EEG recording while engaged in a color identification task. Each trial began with an emotional prime. Response times indicated whether emotional primes facilitated or interfered with performance. Related effects were detected in theta-band power over parietal-occipital cortex, early in the response epoch (<500ms). Children in the emotion facilitation group showed greater theta synchronization for negative stimuli...
February 22, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28237594/efficacy-of-a-high-free-iodine-barrier-teat-disinfectant-for-the-prevention-of-naturally-occurring-new-intramammary-infections-and-clinical-mastitis-in-dairy-cows
#12
C M M R Martins, E S C Pinheiro, M Gentilini, M Lopez Benavides, M V Santos
Using a natural exposure trial design, the goal of our study was to evaluate the clinical efficacy of an iodine teat disinfectant with barrier properties and a high level of free iodine relative to a conventional iodine teat disinfectant with no barrier properties and low levels of free iodine. During the 18 wk of the trial, quarter milk samples were collected every 2 wk from 385 dairy cows from 2 herds. Cows on both farms were assigned in a balanced way according to milk yield, number of lactation, days in milk, somatic cell count (SCC) and microbiology culture pretrial into one of following groups: nonbarrier post milking teat disinfectant (NBAR; n = 195 cows; 747 quarters) or barrier postmilking teat disinfectant (BAR; n = 190 cows; 728 quarters)...
February 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28237530/evaluation-of-prostate-cancer-risk-calculators-for-shared-decision-making-across-diverse-urology-practices-in-michigan
#13
Gregory B Auffenberg, Selin Merdan, David C Miller, Karandeep Singh, Benjamin R Stockton, Khurshid R Ghani, Brian T Denton
OBJECTIVE: To compare the predictive performance of a logistic regression model developed with contemporary data from a diverse group of urology practices to that of the Prostate Cancer Prevention Trial (PCPT) risk calculator version 2.0. METHODS: With data from all first-time prostate biopsies performed between January 2012 and March 2015 across the Michigan Urological Surgery Improvement Collaborative (MUSIC), we developed a multinomial logistic regression model to predict the likelihood of finding high-grade (Gleason Score ≥7), low-grade (Gleason Score ≤6), or no cancer on prostate biopsy...
February 22, 2017: Urology
https://www.readbyqxmd.com/read/28237416/the-combined-effects-of-menstrual-cycle-phase-and-acute-stress-on-reward-related-processing
#14
Stella Banis, Monicque M Lorist
We investigated the combined effects of menstrual cycle phase and acute stress on reward-related processing, employing a monetary incentive delay task in combination with EEG. Females participated during late follicular and late luteal phases, performing in both control and stress conditions. We found evidence for both independent and interaction effects of phase and stress on reward-related brain activity. Phase modulated the sensitivity to feedback valence, with a stronger signaling of negative performance outcomes in the late follicular versus late luteal phase...
February 22, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28237243/non-small-cell-lung-cancer-patients-with-adenocarcinoma-morphology-have-a-better-outcome-compared-with-patients-diagnosed-with-non-small-cell-lung-cancer-favor-adenocarcinoma
#15
Iris Shiran, Eyal Heller, Shlomit Jessel, Iris Kamer, Inbal Daniel-Meshulam, Rossie Navon, Damien Urban, Amir Onn, Jair Bar
BACKGROUND: Non-small-cell lung cancer (NSCLC) includes 2 major histologic subtypes: squamous cell carcinoma and non-squamous carcinoma, mainly adenocarcinoma, a distinction that carries significant clinical and therapeutic implications. NSCLC is diagnosed as adenocarcinoma or as squamous cell carcinoma on the basis of histologic parameters. However, when morphology is inconclusive, tumors with immunohistochemistry (IHC) findings characteristic of adenocarcinoma are referred to as "NSCLC favor adenocarcinoma" (NFA)...
February 2, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28235633/cell-therapy-for-heart-disease-after-15-years-unmet-expectations
#16
REVIEW
Patrizia Nigro, Beatrice Bassetti, Laura Cavallotti, Valentina Catto, Corrado Carbucicchio, Giulio Pompilio
Over the past two decades cardiac cell therapy (CCT) has emerged as a promising new strategy to cure heart diseases at high unmet need. Thousands of patients have entered clinical trials for acute or chronic heart conditions testing different cell types, including autologous or allogeneic bone marrow (BM)-derived mononuclear or selected cells, BM- or adipose tissue-derived mesenchymal cells, or cardiac resident progenitors based on their potential ability to regenerate scarred or dysfunctional myocardium. Nowadays, the original enthusiasm surrounding the regenerative medicine field has been cushioned by a cumulative body of evidence indicating an inefficient or modest efficacy of CCT in improving cardiac function, along with the continued lack of indisputable proof for long-term prognostic benefit...
February 21, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28231700/effect-on-quanti-quality-milk-and-mozzarella-cheese-characteristics-with-further-increasing-the-level-of-dried-stoned-olive-pomace-in-diet-for-lactating-buffalo
#17
Agnese Taticchi, Settimio Bartocci, Maurizio Servili, Sabrina Di Giovanni, Mariano Pauselli, Evangelia Mourvaki, David Meo Zilio, Stefano Terramoccia
Objective: Following a previous report, an experiment was conducted to determine the effect of increasing level of DSOP (dried stoned olives pomaces) in the diet of lactating buffaloes on milk and mozzarella cheese yield and characteristics. Methods: Sixteen pluriparous buffaloes distributed into two groups were fed an isoenergetic (0.9 Milk FU/kg) and isoprotein (149 g/kg DM of crude protein) diet, with or without DSOP. Each animal received 17 kg DM/d. Samples of forages and concentrates were weekly collected and used for duplicate chemical analyses...
February 23, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28231604/variations-in-body-morphology-explain-gender-differences-in-thermoeffector-function-during-compensable-heat-stress
#18
Sean R Notley, Joonhee Park, Kyoko Tagami, Norikazu Ohnishi, Nigel A S Taylor
Gender is sometimes thought to independently modulate cutaneous vasomotor and sudomotor function during heat exposure. Nevertheless, it was hypothesised that, when assessed during compensable exercise that evoked equal heat-loss requirements across participants, gender differences in those thermoeffectors would be explained by variations in the ratio between body surface area and mass (specific surface area). To evaluate that possibility, vasomotor and sudomotor functions were assessed in sixty individuals (36 males, 24 females) with widely varying (overlapping) specific surface areas (range: 232...
February 23, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28231494/marijuana-and-other-substance-use-among-male-and-female-underage-drinkers-who-drive-after-drinking-and-ride-with-those-who-drive-after-drinking
#19
Lisa Buckley, Erin E Bonar, Maureen A Walton, Patrick M Carter, Diana Voloshyna, Peter F Ehrlich, Rebecca M Cunningham
The study sought to describe the occurrence of adolescent driving after drinking (DD) and riding with a driver who had been drinking (RWDD) and associations with substance use for both males and females. As part of screening for a randomized controlled trial, we surveyed 16-20year olds (N=3418) recruited from an emergency department (ED) and analyzed data from those reporting past-year alcohol consumption (n=2150, 58% females). DD was reported by 22% of females and 28% of males and RWDD was reported by 39% of females and 38% of males, also in the past year...
February 10, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28231381/hippocampal-prefrontal-theta-phase-synchrony-in-planning-of-multi-step-actions-based-on-memory-retrieval
#20
Seiya Ishino, Susumu Takahashi, Masaaki Ogawa, Yoshio Sakurai
Planning of multi-step actions based on the retrieval of acquired information is essential for efficient foraging. The hippocampus (HPC) and prefrontal cortex (PFC) may play critical roles in this process. However, in rodents, many studies investigating such roles utilized T-maze tasks that only require one-step actions (i.e., selection of one of two alternatives), in which memory retrieval and selection of an action based on the retrieval cannot be clearly differentiated. In monkeys, PFC has been suggested to be involved in planning of multi-step actions; however, the synchrony between HPC and PFC has not been evaluated...
February 23, 2017: European Journal of Neuroscience
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