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https://www.readbyqxmd.com/read/29166673/factors-related-to-acupuncture-response-in-patients-with-chronic-severe-functional-constipation-secondary-analysis-of-a-randomized-controlled-trial
#1
Xingyue Yang, Yan Liu, Bing Liu, Liyun He, Zhishun Liu, Yanshi Yan, Jia Liu, Baoyan Liu
BACKGROUND: Acupuncture has been demonstrated to be effective and safe for chronic severe functional constipation (CSFC). However, which patients with CSFC will have a better response to acupuncture remains unclear. OBJECTIVE: To explore factors related to acupuncture response in patients with CSFC. METHODS: We performed a secondary analysis of a previous multicenter randomized controlled trial consisting of a 2-week run-in period, 8-week treatment, and 12-week follow-up without treatment in which patients with CSFC were randomly allocated to an electroacupuncture group or a sham electroacupuncture group...
2017: PloS One
https://www.readbyqxmd.com/read/29166257/raoultella-planticola-a-rare-cause-of-wound-infection
#2
Shana S Kalaria, Kristina Elliott, Neal Combs, Linda G Phillips
Raoultella planticola is a gram-negative, aerobic, rod bacterium commonly found in the environment, particularly in water, soil, and fish. This organism has been found to cause a variety of infections, such as necrotizing fasciitis, cystitis, cholecystitis, pancreatitis, hepatic disease, and soft tissue infections. The authors report the case of a 73-year-old-woman who presented with a R planticola wound infection of her left lower extremity after a dog scratch. She was treated successfully with local wound care using dehydrated human amnion/chorion and oral levofloxacin...
November 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29166185/could-a-certain-sitting-position-reduce-the-pain-experienced-by-a-child-the-benefits-of-parental-holding-and-an-upright-position
#3
Ni Made Sri Rahyanti, Nani Nurhaeni, Dessie Wanda
Intravenous injection is the most feared medical procedure and gives rise to an experience of mild to severe pain in children. Unrestrained pain has a negative effect on the child. Pain management in the form of a convenient sitting position is needed by children who undergo intravenous injection procedures. This study aims to determine the effect of parental holding and an upright position on children's pain during intravenous injection procedures. The study used the Randomized Clinical Trial method involving 34 respondents, aged 1-4 years, who were included in the intervention and control group...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29165558/-she-had-a-smile-on-her-face-as-wide-as-the-great-australian-bite-a-qualitative-examination-of-family-perceptions-of-a-therapeutic-robot-and-a-plush-toy
#4
Wendy Moyle, Marguerite Bramble, Cindy J Jones, Jenny E Murfield, Barbara J Bowers
Background and Objectives: Recent years have seen social robotic pets introduced as a means of treating behavioral and psychological symptoms of dementia, and many show promising potential. In this study, we sought to explore family members' perceptions of the Japanese-developed baby harp seal, Paro (version 9), and a look-alike, nonrobotic Plush Toy, when used by their relative with dementia for 15 min, 3 afternoons per week for 10 weeks. Research Design and Method: The study employed a descriptive qualitative approach, which was nested within a larger cluster randomized controlled trial...
November 19, 2017: Gerontologist
https://www.readbyqxmd.com/read/29165013/efficacy-and-safety-of-native-versus-pegylated-escherichia-coli-asparaginase-for-treatment-of-adults-with-high-risk-philadelphia-chromosome-negative-acute-lymphoblastic-leukemia
#5
Josep-Maria Ribera, Mireia Morgades, Pau Montesinos, Rodrigo Martino, Pere Barba, Beatriz Soria, Arancha Bermúdez, María-José Moreno, José González-Campos, Susana Vives, Cristina Gil, Eugenia Abella, Ramon Guàrdia, Daniel Martínez-Carballeira, Pilar Martínez-Sánchez, María-Luz Amigo, Santiago Mercadal, Alfons Serrano, Aurelio López-Martínez, Ferran Vall-Llovera, María-José Sánchez-Sánchez, María-Jesús Peñarrubia, María Calbacho, Jose-Angel Méndez, Juan Bergua, Antonia Cladera, Mar Tormo, Daniel García-Belmonte, Evarist Feliu, Juana Ciudad, Alberto Orfao
Native or pegylated (PEG) asparaginase (ASP) are commonly used in treatment of acute lymphoblastic leukemia (ALL), but have been scarcely compared in the same trial in adult patients. Native vs. PEG-ASP administered according to availability in each center were prospectively evaluated in adults with high-risk ALL. Ninety-one patients received native ASP and 35 PEG-ASP in induction. No significant differences were observed in complete remission, minimal residual disease levels after induction and after consolidation, disease-free survival, and overall survival...
November 22, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29164140/phenotypic-and-genotypic-features-of-a-salmonella-heidelberg-strain-isolated-in-broilers-in-brazil-and-their-possible-association-to-antibiotics-and-short-chain-organic-acids-resistance-and-susceptibility
#6
Elizabeth Santin, Ricardo Mitsuo Hayashi, Jessica Caroline Wammes, Ricardo Gonzalez-Esquerra, Marcelo Falsarella Carazzolle, Caio César de Melo Freire, Paulo Sérgio Monzani, Anderson Ferreira da Cunha
Salmonella enterica serovar Heidelberg is a human pathogen also found in broilers. A strain (UFPR1) has been associated with field reports of resistance to short-chain organic acids (SCOA) in broilers in the South of Brazil, but was susceptible to a Bacillus subtilis-based probiotic added in feed in a related study. This work aimed to (i) report clinical symptoms caused by SH UFPR1 in broilers, (ii) study its susceptibility to some antibiotics in vitro, and (iii) SCOA in vivo; and (iv) relate these phenotypic observations with its genome characteristics...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29163985/response-to-inhaled-loxapine-in-patients-with-schizophrenia-or-bipolar-i-disorder-panss-ec-responder-analyses
#7
Scott Zeller, Leslie Zun, James V Cassella, Daniel A Spyker, Paul P Yeung
Background: Efficacy of inhaled loxapine 5 or 10 mg in treating agitation was shown using the Positive and Negative Syndrome Scale - Excited Component (PANSS-EC) in two Phase III randomised, double-blind, placebo-controlled trials in 344 agitated patients with schizophrenia and 314 patients with bipolar I disorder (Clinicaltrials.gov: NCT00628589, NCT00721955). Aims: To examine the five individual items comprising the PANSS-EC and the percentage of patients achieving a clinical response (reduction of ≥40%) in PANSS-EC (Response-40) for these two studies...
November 2017: BJPsych Open
https://www.readbyqxmd.com/read/29163863/cognitive-therapy-and-eye-movement-desensitization-and-reprocessing-for-reducing-psychopathology-among-disaster-bereaved-individuals-study-protocol-for-a-randomized-controlled-trial
#8
Lonneke I M Lenferink, Eline Piersma, Jos de Keijser, Geert E Smid, Paul A Boelen
Background: Confrontation with a traumatic (e.g. disaster-related) loss is a risk factor for the development of psychopathology, including symptoms of prolonged grief (PG), posttraumatic stress (PTS), and depression. Although interventions have been developed for reducing post-loss psychopathology, more research into the effectiveness of treatment is needed to improve care for bereaved persons. Cognitive therapy (CT) and eye movement desensitization and reprocessing (EMDR) have been shown to be effective in trauma-exposed populations...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/29163644/evaluation-of-amprolium-and-toltrazuril-efficacy-in-controlling-natural-intestinal-rabbit-coccidiosis
#9
A El-Ghoneimy, I El-Shahawy
This trial was undertaken with the objective to evaluate the efficacy of amprolium, toltrazuril and their combination in rabbits naturally infected with Eimeria species (32 × 10(3) ± 4.63 oocysts per gram (OPG) of faeces). Thirty-six rabbits (11 weeks old with average body weight (BW) 2000 ± 75 g), were randomly allocated into six groups (six kits each), namely, negative untreated and was retained as negative control (group 1), infected and kept untreated (group 2), treated with single oral dose of amprolium at 50 mg/kg BW for 5 days (group 3), received toltrazuril at 5 mg/kg BW for 2 days (group 4), treated orally with toltrazuril at 2...
2017: Iranian journal of veterinary research
https://www.readbyqxmd.com/read/29163565/genotypic-variation-in-nitrogen-utilization-efficiency-of-oilseed-rape-brassica-napus-under-contrasting-n-supply-in-pot-and-field-experiments
#10
Huiying He, Rui Yang, Yajun Li, Aisheng Ma, Lanqin Cao, Xiaoming Wu, Biyun Chen, Hui Tian, Yajun Gao
Oilseed rape (Brassica napus) characteristically has high N uptake efficiency and low N utilization efficiency (NUtE, seed yield/shoot N accumulation). Determining the NUtE phenotype of various genotypes in different growth conditions is a way of finding target traits to improve oilseed rape NUtE. The aim of this study was to compare oilseed rape genotypes grown on contrasting N supply rates in pot and field experiments to investigate the genotypic variations of NUtE and to identify indicators of N efficient genotypes...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29163255/positive-emotion-facilitates-cognitive-flexibility-an-fmri-study
#11
Yanmei Wang, Jie Chen, Zhenzhu Yue
Cognitive flexibility is the ability to switch rapidly between multiple goals. By using a task-switching paradigm, the present study investigated how positive emotion affected cognitive flexibility and the underlying neural mechanisms. After viewing pictures of different emotional valence (positive, negative, or neutral), participants discriminated whether a target digit in a specific color was odd or even. After a series of trials, the color of target stimuli was changed, i.e., the switch condition. Switch costs were measured by the increase of reaction times (RTs) in the switch trials compared to those in the repeat trials...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29163162/a-randomized-double-blinded-clinical-trial-on-effects-of-a-vitis-vinifera-extract-on-cognitive-function-in-healthy-older-adults
#12
Gioacchino Calapai, Francesco Bonina, Andrea Bonina, Luisa Rizza, Carmen Mannucci, Vincenzo Arcoraci, Germana Laganà, Angela Alibrandi, Concetta Pollicino, Santi Inferrera, Umberto Alecci
Introduction: Gradual population aging is creating a new set of needs in the general population. Memory capacity decreases with age, and memory deficits are considered an early symptom of Alzheimer's Disease (AD), one of the most prevalent cognitive disorders in older people. Numerous studies have shown that grape polyphenolic compounds (GPs) are able to attenuate cognitive impairment and reduce brain lesions in experimental AD animal models. These GP effects are associated with improvement in brain antioxidant status and prevention of free radical-induced neuronal damage...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29163113/changes-of-attention-during-value-based-reversal-learning-are-tracked-by-n2pc-and-feedback-related-negativity
#13
Mariann Oemisch, Marcus R Watson, Thilo Womelsdorf, Anna Schubö
Previously learned reward values can have a pronounced impact, behaviorally and neurophysiologically, on the allocation of selective attention. All else constant, stimuli previously associated with a high value gain stronger attentional prioritization than stimuli previously associated with a low value. The N2pc, an ERP component indicative of attentional target selection, has been shown to reflect aspects of this prioritization, by changes of mean amplitudes closely corresponding to selective enhancement of high value target processing and suppression of high value distractor processing...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29163101/eeg-frequency-changes-prior-to-making-errors-in-an-easy-stroop-task
#14
Rachel Atchley, Daniel Klee, Barry Oken
Background: Mind-wandering is a form of off-task attention that has been associated with negative affect and rumination. The goal of this study was to assess potential electroencephalographic markers of task-unrelated thought, or mind-wandering state, as related to error rates during a specialized cognitive task. We used EEG to record frontal frequency band activity while participants completed a Stroop task that was modified to induce boredom, task-unrelated thought, and therefore mind-wandering. Methods: A convenience sample of 27 older adults (50-80 years) completed a computerized Stroop matching task...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29163004/cardiac-concomitants-of-feedback-and-prediction-error-processing-in-reinforcement-learning
#15
Lucas Kastner, Jana Kube, Arno Villringer, Jane Neumann
Successful learning hinges on the evaluation of positive and negative feedback. We assessed differential learning from reward and punishment in a monetary reinforcement learning paradigm, together with cardiac concomitants of positive and negative feedback processing. On the behavioral level, learning from reward resulted in more advantageous behavior than learning from punishment, suggesting a differential impact of reward and punishment on successful feedback-based learning. On the autonomic level, learning and feedback processing were closely mirrored by phasic cardiac responses on a trial-by-trial basis: (1) Negative feedback was accompanied by faster and prolonged heart rate deceleration compared to positive feedback...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29162766/production-and-rearing-of-germ-free-x-scid-pigs
#16
Hiromasa Hara, Hiroaki Shibata, Kazuaki Nakano, Tomoyuki Abe, Hideki Uosaki, Takahiro Ohnuki, Shuji Hishikawa, Satoshi Kunita, Masahito Watanabe, Osamu Nureki, Hiroshi Nagashima, Yutaka Hanazono
Pigs with X-linked severe combined immunodeficiency (X-SCID) caused by a mutation of the interleukin-2 receptor gamma chain gene (IL2RG) are of value for a wide range of studies. However, they do not survive longer than 8 weeks because of their susceptibility to infections. To allow longer survival of X-SCID pigs, the animals must be born and reared under germ-free conditions. Here, we established an efficient system for piglet derivation by hysterectomy and used it to obtain and maintain a germ-free X-SCID pig...
November 21, 2017: Experimental Animals
https://www.readbyqxmd.com/read/29162610/angiography-versus-hemodynamics-to-predict-the-natural-history-of-coronary-stenoses-a-fame-2-substudy
#17
Giovanni Ciccarelli, Emanuele Barbato, Gabor G Toth, Brigitta Gahl, Panagiotis Xaplanteris, Stephane Fournier, Anastasios Milkas, Jozef Bartunek, Marc Vanderheyden, Nico Pijls, Pim Tonino, William F Fearon, Peter Jüni, Bernard De Bruyne
Background -Among patients with documented stable coronary artery disease (CAD) and in whom no revascularization was performed, we compared the respective values of angiographic diameter stenosis (DS) and of fractional flow reserve (FFR) in predicting natural history. Methods -The present analysis included the 607 patients from the Fractional flow reserve versus angiography in multivessel evaluation 2 (FAME 2) trial in whom no revascularization was performed. FFR varied from 0.20 to 1.00 (average 0.74 ± 0...
November 21, 2017: Circulation
https://www.readbyqxmd.com/read/29162134/serum-thymidine-kinase-1-activity-as-a-pharmacodynamic-marker-of-cyclin-dependent-kinase-4-6-inhibition-in-patients-with-early-stage-breast-cancer-receiving-neoadjuvant-palbociclib
#18
Nusayba Bagegni, Shana Thomas, Ning Liu, Jingqin Luo, Jeremy Hoog, Donald W Northfelt, Matthew P Goetz, Andres Forero, Mattias Bergqvist, Jakob Karen, Magnus Neumüller, Edward M Suh, Zhanfang Guo, Kiran Vij, Souzan Sanati, Matthew Ellis, Cynthia X Ma
BACKGROUND: Thymidine kinase 1 (TK1) is a cell cycle-regulated enzyme with peak expression in the S phase during DNA synthesis, and it is an attractive biomarker of cell proliferation. Serum TK1 activity has demonstrated prognostic value in patients with early-stage breast cancer. Because cyclin-dependent kinase 4/6 (CDK4/6) inhibitors prevent G1/S transition, we hypothesized that serum TK1 could be a biomarker for CDK4/6 inhibitors. We examined the drug-induced change in serum TK1 as well as its correlation with change in tumor Ki-67 levels in patients enrolled in the NeoPalAna trial (ClinicalTrials...
November 21, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29161963/age-differences-in-cognitive-flexibility-when-overcoming-a-preexisting-bias-through-feedback
#19
Cristina G Wilson, Amy T Nusbaum, Paul Whitney, John M Hinson
INTRODUCTION: Older adults are often worse than younger adults at adapting to changing situational demands, and this difference is commonly attributed to an age-related decline in acquiring and updating information. Previous research on aging and cognitive flexibility has used measures that require adapting to novel associations learned during a laboratory task (e.g., choice X led to positive outcomes but now leads to negative outcomes). However, in everyday life people must frequently overcome associations based on preexisting beliefs and biases (e...
November 21, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/29161068/the-nazi-physicians-as-leaders-in-eugenics-and-euthanasia-lessons-for-today
#20
Michael A Grodin, Erin L Miller, Johnathan I Kelly
This article, in commemoration of the 70th anniversary of the Doctors' Trial at Nuremberg, reflects on the Nazi eugenics and "euthanasia" programs and their relevance for today. The Nazi doctors used eugenic ideals to justify sterilizations, child and adult "euthanasia," and, ultimately, genocide. Contemporary euthanasia has experienced a progression from voluntary to nonvoluntary and from passive to active killing. Modern eugenics has included both positive and negative selective activities. The 70th anniversary of the Doctors' Trial at Nuremberg provides an important opportunity to reflect on the implications of the Nazi eugenics and "euthanasia" programs for contemporary health law, bioethics, and human rights...
November 21, 2017: American Journal of Public Health
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