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https://www.readbyqxmd.com/read/28433820/effects-of-punctal-occlusion-on-global-tear-proteins-in-patients-with-dry-eye
#1
Louis Tong, Lei Zhou, Roger Beuerman, Susan Simonyi, David A Hollander, Michael E Stern
PURPOSE: To investigate effects of punctal occlusion on global tear protein levels in patients with dry eye. METHODS: In this prospective, longitudinal, single-center study, nonabsorbable punctal plugs were inserted bilaterally into the lower punctum of 30 patients with moderate dry eye. Dry eye symptoms, fluorescein corneal staining, Schirmer I test, tear film break-up time, and safety were assessed in the more severe eye. Tear proteins at weeks 1 and 3 were quantified by iTRAQ relative to baseline preocclusion levels...
April 19, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28431436/enhanced-tearing-by-electrical-stimulation-of-the-anterior-ethmoid-nerve
#2
Mark Brinton, Andrea L Kossler, Zara M Patel, James Loudin, Manfred Franke, Christopher N Ta, Daniel Palanker
Purpose: Electrical neurostimulation enhances tear secretion, and can be applied to treatment of dry eye disease. Using a chronic implant, we evaluate the effects of stimulating the anterior ethmoid nerve on the aqueous, lipid, and protein content of secreted tears. Methods: Neurostimulators were implanted beneath the nasal mucosa in 13 New Zealand white rabbits. Stimulations (2.3-2.8 mA pulses of 75-875 μs in duration repeated at 30-100 Hz for 3 minutes) were performed daily, for 3 weeks to measure changes in tear volume (Schirmer test), osmolarity (TearLab osmometer), lipid (Oil-Red-O staining), and protein (BCA assay, mass spectrometry)...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28428095/sjogren-s-syndrome-clinical-aspects
#3
Frederick B Vivino
Sjogren's syndrome (SS) is the 2nd most common chronic autoimmune rheumatic disease and associated with a high burden of illness. Morbidity arises not only from untreated xerostomia and keratoconjunctivitis sicca but also from extra-glandular manifestations and the development of non-Hodgkin's B cell lymphomas. Proper diagnosis of SS requires objective evidence of dry eyes and/or objective evidence of dry mouth and proof of autoimmunity. The recent development of new international classification criteria and clinical practice guidelines for SS should not only enhance the existing standards of care but also facilitate further studies to improve future diagnosis and management...
April 17, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28427352/point-of-sampling-detection-of-zika-virus-within-a-multiplexed-kit-capable-of-detecting-dengue-and-chikungunya
#4
Ozlem Yaren, Barry W Alto, Priyanka V Gangodkar, Shatakshi R Ranade, Kunal N Patil, Kevin M Bradley, Zunyi Yang, Nikhil Phadke, Steven A Benner
BACKGROUND: Zika, dengue, and chikungunya are three mosquito-borne viruses having overlapping transmission vectors. They cause diseases having similar symptoms in human patients, but requiring different immediate management steps. Therefore, rapid (< one hour) discrimination of these three viruses in patient samples and trapped mosquitoes is needed. The need for speed precludes any assay that requires complex up-front sample preparation, such as extraction of nucleic acids from the sample...
April 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28426869/expression-profiling-of-nonpolar-lipids-in-meibum-from-patients-with-dry-eye-a-pilot-study
#5
Jianzhong Chen, Jeremy K Keirsey, Kari B Green, Kelly K Nichols
Purpose: The purpose of this investigation was to characterize differentially expressed lipids in meibum samples from patients with dry eye disease (DED) in order to better understand the underlying pathologic mechanisms. Methods: Meibum samples were collected from postmenopausal women with DED (PW-DED; n = 5) and a control group of postmenopausal women without DED (n = 4). Lipid profiles were analyzed by direct infusion full-scan electrospray ionization mass spectrometry (ESI-MS)...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28425227/primary-sj%C3%A3-gren-s-syndrome-in-patients-with-celiac-disease
#6
Funda Erbasan, Deniz Turgut Çoban, Uğur Karasu, Yeşim Çekin, Bayram Yeşil, Ayhan Hilmi Çekin, Dinç Süren, Mustafa Ender Terzioğlu
BACKGROUND/AIM: Many autoimmune diseases occur concomitantly with celiac disease (CD). We aimed to determine the frequency of Sjögren's syndrome (SS) in CD patients based on SS-specific serology verified by minor labial salivary biopsy. MATERIALS AND METHODS: Eight-two patients with CD were included in the study. After examination for objective evidence of sicca complex, all patients were tested for serological presence of rheumatoid factor (RF) and antinuclear antibodies (ANAs) and for ANA profile...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28424547/omega-3-fatty-acid-supplementation-can-improve-both-symptoms-and-signs-of-dry-eye-disease
#7
COMMENT
Jae-Woo Kwon, Sang Beom Han
No abstract text is available yet for this article.
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28422804/a-review-of-ocular-graft-versus-host-disease
#8
Saleha Z Munir, James Aylward
: Graft-versus-host disease (GVHD) is a major complication that occurs following allogeneic hematopoietic stem cell transplantation, which is a potential curative therapy used in a variety of malignant or benign hematological diseases. Graft-versus-host disease primarily occurs in many organs, but most notably in the skin, lungs, gastrointestinal tract, liver, eyes, mucosa, and musculoskeletal system. Ocular manifestations of GVHD may precede other systemic GVHD findings, and it may be a poor prognosis for mortality...
May 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28422418/factors-associated-with-mucosal-dryness-in-multiple-regions-and-skin-a-web-based-study-in-women
#9
Kayoko Ito, Kiyoshi Takamatsu, Kaname Nohno, Aki Sugano, Saori Funayama, Kouji Katsura, Noboru Kaneko, Mariko Ogawa, Jukka H Meurman, Makoto Inoue
AIM: We hypothesized that feeling mucosal dryness in one body region and the skin may be associated with dryness in other regions and that there are common background factors for dryness. In an earlier web-based survey, we reported prevalence figures of dry eyes, nose, mouth, skin, and vagina. In the present study, additional analyses were made to investigate the factors associated with dryness in each region, and simultaneous dryness in multiple regions. METHODS: A web-based questionnaire was completed by 310 Japanese women...
April 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28420926/femto-lasik-the-recent-innovation-in-laser-assisted-refractive-surgery
#10
Zubair Shahid Bashir, Muhammad Hassaan Ali, Ayesha Anwar, Muhammad Hammad Ayub, Nadeem Hafeez Butt
Femtosecond laser has been introduced in refractive surgery to create a thin-hinged corneal flap without using any blade. The current review was planned to analyse and compare femtosecond-assisted laser in-situ keratomileusis (LASIK), the latest refractive procedure, with conventional techniques in refractive surgery. The analysis showed that femtosecond-assisted LASIK yielded more predictable corneal flaps, lesser ocular aberrations, better uncorrected visual acuity, lesser variations in intraocular pressure (IOP) and fewer chances of developing dry eyes...
April 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28419396/correlation-between-mesopic-retinal-sensitivity-and-optical-coherence-tomographic-metrics-of-the-outer-retina-in-patients-with-non-atrophic-dry-age-related-macular-degeneration
#11
Tudor C Tepelus, Amir H Hariri, Mayss Al-Sheikh, SriniVas R Sadda
BACKGROUND AND OBJECTIVE: To determine the correlation between mesopic retinal sensitivity and optical coherence tomographic metrics of the outer retina in patients with intermediate age-related macular degeneration (AMD). PATIENTS AND METHODS: Participants with nonatrophic dry AMD underwent mesopic MP-3 microperimetry (Nidek, Padova, Italy) and both Nidek and Cirrus (Carl Zeiss Meditec, Dublin, CA) spectral-domain optical coherence tomography (SD-OCT). The volume of the outer retinal layers was measured on the Nidek SD-OCT scans using the automatic segmentation algorithm of Navis-EX software...
April 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28410282/new-insights-into-the-lipid-layer-of-the-tear-film-and-meibomian-glands
#12
Reiko Arita, Shima Fukuoka, Naoyuki Morishige
Meibomian glands secrete lipids (meibum) that form the surface lipid layer of the tear film and thereby prevent excessive evaporation of tear fluid. Meibomian gland dysfunction is a major cause of evaporative dry eye, which is more prevalent than aqueous-deficient dry eye. Noninvasive meibography with infrared light and an infrared charge-coupled device camera can detect morphological changes of meibomian glands in both upper and lower eyelids, whereas tear interferometry allows qualitative and quantitative evaluations of the lipid layer of the tear film...
April 12, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28401923/the-prevalence-of-depression-and-depressive-symptoms-among-eye-disease-patients-a-systematic-review-and-meta-analysis
#13
Yajing Zheng, Xiaohang Wu, Xiaoming Lin, Haotian Lin
The prevalence of depression among different eye disease patients varies across studies and has not been systematically reviewed. This study is to provide a summary of the prevalence of depression among eye disease patients. PubMed, Medline, Embase and Cochrane Library were searched from January, 1990 to December, 2015 to identify studies with information on the prevalence of depression among ophthalmic patients. A random/fixed-effects meta-analysis was used to estimate the pooled prevalence of depression among eye disease patients...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28400372/risk-factors-for-bleb-related-infection-following-trabeculectomy-surgery-ocular-surface-findings-a-case-control-study
#14
Poornima A Rai, Keith Barton, Ian E Murdoch
PURPOSE: Bleb-related infection (BRI) is a devastating complication of trabeculectomy surgery. The aim of this study was to identify ocular risk factors for BRI with specific emphasis on ocular surface parameters. It has been suggested that the frequency has increased since the introduction of antimetabolites, particularly mitomycin C. DESIGN: A case-control study. METHOD: A clinical study of BRI following trabeculectomy surgery to investigate risk factors by documenting historical data review from patients records, self-reported questionnaire specific to ocular surface symptoms and a repeat detailed clinical examination of the lid, ocular surface and tear film...
October 18, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28399249/lifitegrast-xiidra-for-dry-eye-disease
#15
(no author information available yet)
No abstract text is available yet for this article.
April 11, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28390092/clinical-impact-of-inflammation-in-dry-eye-disease-proceedings-of-the-odissey-group-meeting
#16
REVIEW
Christophe Baudouin, Murat Irkeç, Elisabeth M Messmer, José M Benítez-Del-Castillo, Stefano Bonini, Francisco C Figueiredo, Gerd Geerling, Marc Labetoulle, Michael Lemp, Maurizio Rolando, Gysbert Van Setten, Pasquale Aragona
Dry eye disease (DED) is a common, multifactorial ocular condition with major impact on vision and quality of life. It is now well recognized that the pathophysiology of chronic DED can include a cycle of inflammation involving both innate and adaptive immune responses. Recently, in vitro/in vivo models have been used to obtain a better understanding of DED-related inflammatory processes at molecular/cellular levels although they do not truly reproduce the complex and chronic hallmarks of human DED. In clinical DED research, advanced techniques such as impression cytology, conjunctival biopsy, in vivo confocal microscopy and multiplex tear analyses have allowed an improved assessment of inflammation in DED patients...
April 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28387751/corrigendum-effects-of-silk-fibroin-in-murine-dry-eye
#17
Chae Eun Kim, Ji Hyun Lee, Yeung Kyu Yeon, Chan Hum Park, JaeWook Yang
No abstract text is available yet for this article.
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28385474/geographic-atrophy-and-foveal-sparing-changes-related-to-visual-acuity-in-patients-with-dry-age-related-macular-degeneration-over-time
#18
Ramzi Gilbert Sayegh, Stefan Sacu, Roman Dunavölgyi, Maria Elisabeth Kroh, Philipp Roberts, Christoph Mitsch, Alessio Montuoro, Margit Ehrenmüller, Ursula Schmidt-Erfurth
PURPOSE: To correlate the area of geographic atrophy (GA) and residual foveal sparing (FS), and to identify the minimum FS and maximum GA area allowing sufficient visual acuity (VA) for daily tasks. DESIGN: Prospective cohort study METHODS: Thirty-six eyes of 25 patients with GA and FS were followed for 18 months using spectral-domain optical coherence tomography and VA tests. Volume scans were imported into software enabling grading of areas in B-scans and computing of planimetric measurements in complete volume scans...
April 3, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28384900/efficacy-of-green-tea-extract-for-treatment-of-dry-eye-and-meibomian-gland-dysfunction-a-double-blind-randomized-controlled-clinical-trial-study
#19
Mahmood Nejabat, Salehi Ali Reza, Mehdi Zadmehr, Masoud Yasemi, Zahra Sobhani
INTRODUCTION: With an incidence rate of 9%, dry eye is a common problem of the ocular surface, especially in patients more than 40-year-old. Green tea extract has anti-oxidative, anti-bacterial, anti-androgen, and immunomodulatory properties. AIM: To evaluate the efficacy of green tea extract for treatment of patients with dry eye and Meibomian Gland Dysfunction (MGD). MATERIALS AND METHODS: In a double-blind randomized controlled clinical trial, 60 patients were selected within the age range of 30 to 70 years, and divided into two groups by blocked randomization method...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28380105/accidental-lacrimal-gland-removal-during-resection-of-the-levator-palpebrae-superioris-muscle
#20
Patricia Akaishi, Alicia Galindo-Ferreiro, Sahar M Elkhamary, Zakeya Al-Sadah, Alberto Galvez-Ruiz, A Augusto Cruz
Accidental removal of the lacrimal gland is a rare complication of ptosis surgery. We report two children who underwent large unilateral levator palpebrae superioris resections (LPSr). After surgery, both patients developed dry eye. Post-operatively, the parents of both patients noticed no tears in the affected eye when their child cried. Computed tomography proved the absence of the lacrimal gland in the operated eye in both patients. Oculoplastic surgeons should pay close attention to the anatomy of the levator muscle and its proximity to surrounding tissues in order to avoid lesions on important orbital structures, including the lacrimal gland, and to avoid the development of long-term dry eye...
January 2017: Arquivos Brasileiros de Oftalmologia
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