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https://www.readbyqxmd.com/read/29782336/a-review-of-small-incision-lenticule-extraction-complications
#1
Ronald R Krueger, Caio S Meister
PURPOSE OF REVIEW: As a flapless procedure, SMILE brings benefits to refractive surgery, such as lower corneal biomechanical impact, less dry eye risk and less stromal bed exposure. However, the longer learning curve can be a risk factor for complications. This article aims to discuss SMILE complications and proposes a categorized analysis of occurrences, dividing into two groups: intraoperative and postoperative complications. Among intraoperative, we also suggest a subdivision between those related to the laser (lenticule construction), tissue separation (lenticule dissection) and tissue removal (lenticule extraction)...
May 17, 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29781353/clinical-trials-with-multiple-endpoints-can-establish-a-correlation-but-not-yet-causality-between-dietary-supplementation-with-omega-3-fatty-acids-and-keratoconjunctivitis-sicca
#2
Roger Lee Mendoza
AIM: We review clinical evidence of therapeutic efficacy and effectiveness of omega-3 fatty acids (omega-3s) in keratoconjunctivitis sicca, colloquially known as dry eye disease. In doing so, we identify relevant literature to address the following questions: 1) What definitive guidance can clinical evidence offer eye physicians and their patients? 2) What aspects of omega-3 supplementation lack definitive evidence, and how might economic assessments help? METHODS: A targeted and systematic search strategy based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) was designed in this study for refereed clinical trials of omega-3s in dry eye treatment...
May 21, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29777869/subconjunctival-dendrimer-drug-therapy-for-the-treatment-of-dry-eye-in-rabbits-with-induced-autoimmune-dacryoadenitis
#3
Hui Lin, Ying Liu, Siva P Kambhampati, Chih-Chien Hsu, Rangaramanujam M Kannan, Samuel C Yiu
PURPOSE: To investigate the efficacy of a single subconjunctival injection of dendrimer-dexamethasone to treat dry eye in a rabbit model of induced autoimmune dacryoadenitis (AID). METHOD: Dendrimer biodistribution after subconjuntival injection in AID animals was evaluated using Cy5-labelled dendrimer (D-Cy5) and confocal microscopy. Diseased animals were treated with free dexamethasone (Free-Dex), dendrimer-dexamethasone (D-Dex), or saline via a single subconjunctival injection...
May 16, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29776765/effects-of-artificial-tear-treatment-on-corneal-epithelial-thickness-and-corneal-topography-findings-in-dry-eye-patients
#4
B Çakır, E Doğan, E Çelik, T Babashli, T Uçak, G Alagöz
PURPOSE: To investigate the effects of artificial tear treatment on central corneal epithelial thickness, and central, mid-peripheral and peripheral corneal thicknesses in patients with dry eye disease (DED). MATERIAL-METHODS: Patients with DED underwent ocular examinations, including Schirmer-2 test, slit lamp examination for tear break-up time (BUT), corneal topography (CT) for measuring mean central, mid-peripheral and peripheral corneal thickness values and anterior segment optic coherence tomography (AS-OCT) for obtaining central corneal epithelial thickness...
May 15, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29772277/severity-therapeutic-and-activity-tear-biomarkers-in-dry-eye-disease-a-clinical-trial-sub-analysis
#5
José Pinto-Fraga, Amalia Enríquez-de-Salamanca, Margarita Calonge, María J González-García, Alberto López-Miguel, Alberto López-de la Rosa, Carmen García-Vázquez, Virginia Calder, Michael E Stern, Itziar Fernández
PURPOSE: To evaluate the effect of 0.1%-fluorometholone (FML) on tear inflammatory molecule levels after 22-days treatment in dry eye disease (DED) patients exposed to an adverse controlled environment (ACE), identifying different biomarkers. METHODS: Sub-analysis of a double-masked randomized clinical trial. Forty-one DED patients received 4-drops daily of topical FML (FML-group) or polyvinyl-alcohol (PA-group) for 22 days. At day 21, patients were exposed to an ACE...
May 14, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29765955/pediatric-multiple-endocrine-neoplasia-type-2b-clinicopathological-correlation-of-perilimbal-mucosal-neuromas-and-treatment-of-secondary-open-angle-glaucoma
#6
Ta Chen Chang, Kingsley C Okafor, Kara M Cavuoto, Sander R Dubovy, Carol L Karp
Ocular findings of multiple endocrine neoplasia type 2B (MEN 2B) include prominent corneal nerves, mucosal neuromas of the conjunctiva, glaucoma, and dry eyes. A 15-year-old girl with MEN 2B presents with advanced secondary open-angle glaucoma and bilateral perilimbal masses. High-resolution optical coherence tomography (HR-OCT) of the perilimbal lesions showed normal epithelial thickness and subepithelial lobular areas of mixed reflectivity, which correlates well with histopathologic findings of benign mucosal neuromas...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29765198/management-of-post-lasik-dry-eye-a-multicenter-randomized-comparison-of-a-new-multi-ingredient-artificial-tear-to-carboxymethylcellulose
#7
Avi Wallerstein, W Bruce Jackson, Jeffrey Chambers, Amir M Moezzi, Hugh Lin, Peter A Simmons
Purpose: To compare the efficacy and safety of a preservative-free, multi-ingredient formulation of carboxymethylcellulose 0.5%, hyaluronic acid 0.1%, and organic osmolytes (CMC-HA), to preservative-free carboxymethylcellulose 0.5% (CMC) in the management of postoperative signs and symptoms of dry eye following laser-assisted in situ keratomileusis (LASIK). Methods: This was a double-masked, randomized, parallel-group study conducted in 14 clinical centers in Canada and Australia...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29763694/corneal-fluorescein-staining-and-ocular-symptoms-but-not-schirmer-test-are-useful-as-indicators-of-response-to-treatment-in-chronic-ocular-gvhd
#8
Francisco Amparo, Hasanain Shikari, Ujwala Saboo, Reza Dana
PURPOSE: To evaluate long-term ocular surface clinical signs and symptoms response to therapy in patients with chronic ocular GVHD. METHODS: Retrospective review and data modeling. We reviewed the records of post-bone marrow transplantation patients who were newly diagnosed with ocular GVHD and initiated therapy, and analyzed changes in symptoms (Ocular Surface Disease Index [OSDI]; Symptom Assessment in Dry Eye [SANDE]) and signs (corneal fluorescein staining [CFS]; Schirmer test)...
May 12, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29759118/approach-to-patients-with-suspected-rheumatic-disease
#9
REVIEW
Iaszmin Ventura, Pankti Reid, Reem Jan
Patients with rheumatic disease may present with a myriad of symptoms, from joint pain and rashes to more subtle findings, such as dry eyes and dry mouth. In this article, the authors review in detail the common presenting symptoms of rheumatic disease along with key features in the history and physical examination to help distinguish these from other disease processes.
June 2018: Primary Care
https://www.readbyqxmd.com/read/29757849/ocular-surface-findings-in-patients-with-lichen-planopilaris
#10
Mehdi Gheisari, Sahar Dadkhahfar, Kaveh Fadakar, Reza Mahmoud Robati, Hamideh Moravvej, Mohammad Soleimani, Reza Mirshahi
PURPOSE: Lichen planopilaris (LPP) is a chronic lymphocytic- mediated disorder that selectively involves hair follicles, leading to cicatricial alopecia. The eyelash follicle and meibomian gland (MG) might also be involved in the disease process leading to ocular surface problems. METHODS: In this Cross-sectional case -control study, twenty-three patients with histologically confirmed LPP and 23 healthy controls were recruited in this controlled study. To quantify the signs and symptoms of LPP, we used the Lichen Planopilaris Activity Index...
May 10, 2018: Cornea
https://www.readbyqxmd.com/read/29755816/does-dry-eye-affect-repeatability-of-corneal-topography-measurements
#11
Aysun Şanal Doğan, Canan Gürdal, Mehmet Talay Köylü
Objectives: The purpose of this study was to assess the repeatability of corneal topography measurements in dry eye patients and healthy controls. Materials and Methods: Participants underwent consecutive corneal topography measurements (Sirius; Costruzione Strumenti Oftalmici, Florence, Italy). Two images with acquisition quality higher than 90% were accepted. The following parameters were evaluated: minimum and central corneal thickness, aqueous depth, apex curvature, anterior chamber volume, horizontal anterior chamber diameter, iridocorneal angle, cornea volume, and average simulated keratometry...
April 2018: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29754511/-new-international-consensus-statement-about-the-definition-classification-ethiology-diagnostics-and-therapy-of-dry-eye-tfos-dews-ii
#12
András Berta, Edit Tóth-Molnár, Adrienne Csutak
Ten years have passed since the publication of the DEWS Report that summarized the information based on scientific literature concerning dry eye disease. Hundreds of papers have been published since then and time has come for a new summary. Organized by the Tear Film & Ocular Surface Society, 12 working groups summerized former and recent data. The DEWS II Report was created. The authors of the present publication summarize the most important changes in definition, classification, diagnostics, and therapy concerning dry eye disease...
May 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29748599/real-world-use-of-ranibizumab-for-neovascular-age-related-macular-degeneration-in-taiwan
#13
Yi-Sheng Chang, Wan-Ju Lee, Chen-Chee Lim, Shih-Hao Wang, Sheng-Min Hsu, Yi-Chian Chen, Chia-Yi Cheng, Yu-Ti Teng, Yi-Hsun Huang, Chun-Chieh Lai, Sung-Huei Tseng
This study investigated the "real-world" use of ranibizumab for neovascular age-related macular degeneration (nAMD) in Taiwan and assessed the visual outcome. We reviewed the medical records at National Cheng Kung University Hospital, Taiwan, during 2012-2014 for 264 consecutive eyes of 229 patients with nAMD, who applied for ranibizumab covered by national health insurance. A total of 194 eyes (73.5%) in 179 patients (65.5% men; mean ± standard deviation age 69.4 ± 10.7 years) were pre-approved for treatment...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29747621/prevalence-and-clinical-characteristics-of-dry-eye-disease-in-community-based-type-2-diabetic-patients-the-beixinjing-eye-study
#14
Xinrong Zou, Lina Lu, Yi Xu, Jianfeng Zhu, Jiangnan He, Bo Zhang, Haidong Zou
BACKGROUND: This study was performed to evaluate the prevalence and clinical characteristics of dry eye disease (DED) in community-based type 2 diabetic patients and to identify the associated factors related with DED. METHODS: A total of 1360 type 2 diabetic patients in the Beixinjing community were randomly selected. All participants were given a questionnaire that assessed basic information and subjective symptoms.DED was diagnosed using the revised Japanese DED diagnostic criteria...
May 10, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29743147/incidence-of-sicca-syndrome-is-3-6-fold-higher-in-areas-with-farm-soils-high-in-chromium-and-nickel
#15
Ie-Bin Lian, Ie-Ran Wen, Che-Chun Su
BACKGROUND/PURPOSE: Chromium and nickel are important soil pollutants in Taiwan. Previously, we showed that blood chromium levels correlated strongly with soil chromium levels. Our observation that many patients with dry eyes or a dry mouth came from areas where soils contain high chromium levels prompted us to investigate whether incidence and prevalence of SS are higher in areas where soils contain high levels of heavy metals. METHODS: We used a database from national health insurance (NHI) to study the epidemiology of SS...
May 7, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29740252/beneficial-effect-of-daidzin-in-dry-eye-rat-model-through-the-suppression-of-inflammation-and-oxidative-stress-in-the-cornea
#16
Fan Xiao, Hua Cui, Xiao Zhong
Present investigation evaluates the effect of daidzin in dry eye rat model through the suppression of inflammation and oxidative stress in the cornea. Briefly, electron spine resonance was used for the estimation of radical scavenging activity of daidzin and COX Fluorescent Activity Assay Kit was used for the estimation of PGS activity. Dry eye rat model was developed by removing the lacrimal gland and effect of daidzin was evaluated in dry eye rat model by estimating the fluorescein score, tear volume and expressions of heme oxigenase (HO-1), TNF α, Interlukin 6 (IL-6), matrix metallopeptidase 9 (MMP-9) and PGS-2...
May 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29738351/more-than-meets-the-eye-the-eye-and-migraine-what-you-need-to-know
#17
Kathleen B Digre
Migraine has long been associated with disturbances of vision, especially migraine with aura. However, the eye plays an important role in sensory processing as well. We have found that the visual quality of life is reduced in migraine. In this review, we discuss how the migraine and eye pain pathways are similar and affect many of the common complaints which are seen in ophthalmology and neuro-ophthalmology offices, such as dry eye and postoperative eye pain. We also review other related phenomena, including visual snow and photophobia, which also are related to altered sensory processing in migraine...
June 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29736323/thermal-stimulation-of-the-retina-reduces-bruch-s-membrane-thickness-in-age-related-macular-degeneration-mouse-models
#18
Jan Tode, Elisabeth Richert, Stefan Koinzer, Alexa Klettner, Claus von der Burchard, Ralf Brinkmann, Ralph Lucius, Johann Roider
Purpose: To investigate the effect of thermal stimulation of the retina (TS-R) on Bruch's membrane (BrM) thickness in age-related macular degeneration (AMD) mouse models as a novel concept for the prophylaxis and treatment of dry AMD. Methods: Two knockout AMD mouse models, B6.129P2-Apoetm1Unc /J (ApoE-/-) and B6.129X1-Nfe2I2tm1Ywk /J (NRF2-/-), were chosen. One randomized eye of each mouse in four different groups (two of different age, two of different genotype) of five mice was treated by TS-R (532 nm, 10-ms duration, 50-μm spot size), the fellow eye served as control...
May 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29734186/a-pilot-study-investigating-the-impact-of-topical-nasal-steroid-spray-in-allergic-rhinitis-patients-with-dry-eye
#19
Alper Yenigun, Ahmet Elbay, Remzi Dogan, Orhan Ozturan, Mehmet Hakan Ozdemir
OBJECTIVE: The aim of this study is to demonstrate the effect of nasal steroid treatment on intraocular pressure and dry eye in allergic rhinitis patients with dry eye. MATERIALS AND METHODS: Twenty-nine patients with a diagnosis of allergic rhinitis and dry eye were included. Symptoms and findings of patients before and after nasal steroid therapy were compared. RESULT: Ocular Surface Disease Index scores for dry eye symptoms showed significant improvement after nasal steroid treatment (p = 0...
May 7, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29731797/the-association-between-ocular-problems-and-serum-testosterone-prolactin-and-thyroglobulin-concentrations-in-delayed-phase-of-sulfur-mustard-exposure
#20
Hassan Ghasemi, Nayere Askari, Sakine Moaiedmohseni, Soghrat Faghihzadeh, Susan Kabudanian Ardestani, Elham Faghihzadeh, Tooba Ghazanfari
Background and objective: Aside from direct toxic effects, Sulfur Mustard (SM) induced serum hormone abnormalities may aggravate ocular complaints, including Ocular Surface Discomfort (OSD) (burning, itching, and redness), dry eye sensation, photophobia, blurred vision, foreign body sensation, and pain. The aim of the current study was to investigate the possible association of ocular complaints with serum hormone concentrations in chronic phase of Sulfur Mustard (SM) exposure. Methods: As a part of Sardasht Iran Cohort Study (SICS), 372 SM-exposed patients and 128 non-exposed participants were enrolled...
2018: Iranian Journal of Pathology
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