Simon Hsu, Leila R Zelnick, Nisha Bansal, Julia Brown, Michelle Denburg, Harold I Feldman, Charles Ginsberg, Andrew N Hoofnagle, Tamara Isakova, Mary B Leonard, Benjamin Lidgard, Cassianne Robinson-Cohen, Myles Wolf, Dawei Xie, Bryan R Kestenbaum, Ian H de Boer
Background The ratio of 24,25-dihydroxyvitamin D3 /25-hydroxyvitamin D3 (vitamin D metabolite ratio [VDMR]) may reflect functional vitamin D activity. We examined associations of the VDMR, 25-hydroxyvitamin D (25[OH]D), and 1,25-dihydroxyvitamin D (1,25[OH]2 D) with cardiovascular disease (CVD) in patients with chronic kidney disease. Methods and Results This study included longitudinal and cross-sectional analyses of 1786 participants from the CRIC (Chronic Renal Insufficiency Cohort) Study. Serum 24,25-dihydroxyvitamin D3 , 25(OH)D, and 1,25(OH)2 D were measured by liquid chromatography-tandem mass spectrometry 1 year after enrollment...
July 8, 2023: Journal of the American Heart Association