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https://www.readbyqxmd.com/read/27887750/chronic-kidney-disease
#1
REVIEW
Angela C Webster, Evi V Nagler, Rachael L Morton, Philip Masson
The definition and classification of chronic kidney disease (CKD) have evolved over time, but current international guidelines define this condition as decreased kidney function shown by glomerular filtration rate (GFR) of less than 60 mL/min per 1·73 m(2), or markers of kidney damage, or both, of at least 3 months duration, regardless of the underlying cause. Diabetes and hypertension are the main causes of CKD in all high-income and middle-income countries, and also in many low-income countries. Incidence, prevalence, and progression of CKD also vary within countries by ethnicity and social determinants of health, possibly through epigenetic influence...
November 22, 2016: Lancet
https://www.readbyqxmd.com/read/27818017/low-maternal-25-hydroxyvitamin-d-concentration-increases-the-risk-of-severe-and-mild-preeclampsia
#2
Katharyn M Baca, Hyagriv N Simhan, Robert W Platt, Lisa M Bodnar
PURPOSE: The objective of this case-cohort study was to evaluate the relationship between maternal 25-hydroxyvitamin D (25(OH)D) concentration and preeclampsia overall and by severity. METHODS: From an eligible cohort of 12,861 women who had serum banked from aneuploidy screening in Pittsburgh, Pennsylvania from 1999 to 2010, we randomly sampled a subcohort of 2327 pregnancies and all remaining preeclampsia cases (n = 650 cases). Preeclampsia (defined as new-onset hypertension and proteinuria) and its mild and severe forms were identified using ICD-9 codes...
December 2016: Annals of Epidemiology
https://www.readbyqxmd.com/read/27806690/vitamin-d-deficiency-may-predict-a-poorer-outcome-of-iga-nephropathy
#3
Xiao-Hua Li, Xin-Ping Huang, Ling Pan, Cheng-Yu Wang, Ju Qin, Feng-Wei Nong, Yu-Zhen Luo, Yue Wu, Yu-Ming Huang, Xi Peng, Zhen-Hua Yang, Yun-Hua Liao
BACKGROUND: Experimental studies showed that 25-hydroxy-vitamin D [25(OH)D] deficiency (defined as 25-hydroxy-vitamin D < 15 ng/ml) has been associated with CKD progression. Patients with IgA nephropathy have an exceptionally high rate of severe 25(OH)D deficiency; however, it is not known whether this deficiency is a risk factor for progression of IgA nephropathy. We conducted this study to investigate the relationship between the plasma level of 25(OH)D and certain clinical parameters and renal histologic lesions in the patients with IgA nephropathy, and to evaluate whether the 25(OH)D level could be a good prognostic marker for IgA nephropathy progression...
November 2, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27539761/serum-25-hydroxy-vitamin-d-level-in-preeclamptic-and-normotensive-pregnancies
#4
Naima Umar, Ambreen Tauseef, Fazeela Shahzad, Sana Sabir, Shumaela Kanwal, Ayesha Akmal, Sibgha Zulfiqar
OBJECTIVE: To compare serum 25-hydroxy vitamin D level between preeclamptic and normotensive pregnancies. STUDY DESIGN: Cross-sectional analytical study. PLACE AND DURATION OF STUDY: Department of Physiology, Federal Postgraduate Medical Institute, Shaikh Zayed Hospital, Lahore, in collaboration with Sir Ganga Ram Hospital and Lady Willingdon Hospital, Lahore, from March 2012 to April 2012. METHODOLOGY: Thirty registered preeclamptic patients with systolic and diastolic blood pressure > 140/90 mm Hg on more than two occasions, 6 hours apart, and proteinuria at least 300 mg in 24-hour urine collection; and 30 normotensive uncomplicated pregnant women matched for age, gestational age, parity and BMI were included by convenient sampling technique...
August 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27509583/from-man-to-fish-what-can-zebrafish-tell-us-about-apol1-nephropathy
#5
Opeyemi Olabisi, Khaldoun Al-Romaih, Joel Henderson, Ritu Tomar, Iain Drummond, Calum MacRae, Martin Pollak
BACKGROUND: Risk variant Apolipoprotein L1 (G1/G2) are strongly associated with a spectrum of kidney disease in people of recent African descent. The mechanism of ApoL1 nephropathy is unknown. Podocytes and/or endothelial cells are the presumed target kidney cells. Given the close homology in structure and function of zebrafish (ZF) pronephros and human nephron, we studied the effect of podocyte-specific or endothelium-specific expression of ApoL1 (G0, G1, or G2) on the structure and function of ZF pronephros...
2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27483020/higher-25-hydroxyvitamin-d-levels-are-associated-with-lower-proteinuria-in-kidney-transplant-recipients
#6
Jean J Filipov, Borelli K Zlatkov, Emil P Dimitrov, Dobrin A Svinarov
OBJECTIVES: Proteinuria is associated with decreased graft and patient survival after kidney transplantation. Increasing evidence shows that vitamin D has antiproteinuric and renoprotective effects. The aim of our study was to assess the influence of 25-hydroxyvitamin D levels on proteinuria after kidney transplantation. MATERIAL AND METHODS: Between May 1, 2012, and November 30, 2012, we tested 395 kidney transplant recipients for 25-hydroxyvitamin D levels during their regular visits to our transplant center together with routine blood sampling and proteinuria testing...
August 2, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27438972/effect-of-cholecalciferol-supplementation-on-urine-podocyte-associated-messenger-rnas-in-patients-with-chronic-kidney-disease
#7
João Rodolfo Teló Timm, Cristina Karohl, Mariane Dos Santos, Maysa Lucena de Souza, Rafael Zancan, Rafael de Almeida, Francisco Veríssimo Veronese
INTRODUCTION: Vitamin D reduces albuminuria in patients with chronic kidney disease (CKD) but its effects on glomerular podocytes are not entirely understood. OBJECTIVE: To evaluate if cholecalciferol supplementation reduces the levels of podocyte-associated urine mRNAs in patients with CKD. METHODS: A total of 27 patients with stages 2 to 4 CKD and suboptimal serum vitamin D [25(OH)D] levels were treated with cholecalciferol for 6 months...
June 2016: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/27371107/immunomodulators-in-sle-clinical-evidence-and-immunologic-actions
#8
REVIEW
L Durcan, M Petri
Systemic lupus erythematosus (SLE) is a potentially fatal autoimmune disease. Current treatment strategies rely heavily on corticosteroids, which are in turn responsible for a significant burden of morbidity, and immunosuppressives which are limited by suboptimal efficacy, increased infections and malignancies. There are significant deficiencies in our immunosuppressive armamentarium, making immunomodulatory therapies crucial, offering the opportunity to prevent disease flare and the subsequent accrual of damage...
November 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27362433/establishment-of-nephrin-reporter-mice-and-use-for-chemical-screening
#9
Junichi Tsuchida, Taiji Matsusaka, Masato Ohtsuka, Hiromi Miura, Yukiko Okuno, Katsuhiko Asanuma, Takahiko Nakagawa, Motoko Yanagita, Kiyoshi Mori
Nephrin is a critical component of glomerular filtration barrier, which is important to maintain glomerular structure and avoid proteinuria. Downregulation of nephrin expression is commonly observed at early stage of glomerular disorders, suggesting that methods to increase nephrin expression in podocytes may have therapeutic utility. Here, we generated a knockin mouse line carrying single copy of 5.5 kb nephrin promoter controlling expression of enhanced green fluorescent protein (EGFP) at Rosa26 genomic locus (Nephrin-EGFP mouse)...
2016: PloS One
https://www.readbyqxmd.com/read/27229347/vitamin-d-in-kidney-transplant-recipients-mechanisms-and-therapy
#10
Giuseppe Cianciolo, Andrea Galassi, Irene Capelli, Maria Laura Angelini, Gaetano La Manna, Mario Cozzolino
Chronic kidney disease-mineral and bone disorder (CKD-MBD) is common in kidney transplant recipients (KTRs), where secondary hyperparathyroidism (HPTH) and post-transplantation bone disease (PTBD) are potential effectors of both graft and vascular aging. Reduced 25(OH)D levels are highly prevalent in KTRs. Experimental and clinical evidence support the direct involvement of deranged vitamin D metabolism in CKD-MBD among KTRs. This review analyzes the pathophysiology of vitamin D derangement in KTRs and its fall out on patient and graft outcome, highlighting the roles of both nutritional and active vitamin D compounds to treat PTBD, cardiovascular disease (CVD) and graft dysfunction...
2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27169468/prevalence-of-osteo-renal-impairment-in-the-romanian-hiv-cohort
#11
Anca Streinu-Cercel, Oana Săndulescu, Gabriela Ceapraga, Daniela Manolache, Monica Andreea Stoica, Liliana Lucia Preoțescu, Adrian Streinu-Cercel
BACKGROUND: The Romanian HIV cohort has certain particularities that render it unique in Europe. We have performed a study to evaluate the prevalence of bone and kidney impairment in this particular group of HIV-infected patients. METHODS: We performed dual-energy X-ray absorptiometry (DXA) evaluation of the lumbar vertebrae and the femur, as well as laboratory tests including standard serum panels, bone-related markers and urinalysis in patients from the Romanian HIV cohort...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27147283/correlation-between-disease-activity-of-pediatric-onset-systemic-lupus-erythematosus-and-level-of-vitamin-d-in-taiwan-a-case-cohort-study
#12
Ting-Chun Lin, Jhong-Yong Wu, Ming-Ling Kuo, Liang-Shiou Ou, Kuo-Wei Yeh, Jing-Long Huang
BACKGROUND: Vitamin D deficiency has been associated with systemic lupus erythematosus (SLE), but there is no consensus on the role of serum vitamin D in evaluating or predicting disease activity. This study aimed to demonstrate the direct correlation between vitamin D level and pediatric-onset SLE disease activity by a retrospective cohort study design. PATIENTS AND METHODS: Thirty-five patients with pediatric-onset SLE and paired sera at the active and inactive disease states were enrolled...
January 12, 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/27001276/circulating-adiponectin-concentrations-are-increased-by-dietary-resistant-starch-and-correlate-with-serum-25-hydroxycholecalciferol-concentrations-and-kidney-function-in-zucker-diabetic-fatty-rats
#13
Gar Yee Koh, Rachel Derscheid, Kelly N Z Fuller, Rudy J Valentine, Shu En Leow, Leah Reed, Emily Wisecup, Kevin L Schalinske, Matthew J Rowling
We previously reported that dietary resistant starch (RS) type 2 prevented proteinuria and promoted vitamin D balance in type 2 diabetic (T2D) rats. Here, our primary objective was to identify potential mechanisms that could explain our earlier observations. We hypothesized that RS could promote adiponectin secretion and regulate the renin-angiotensin system activity in the kidney. Lean Zucker rats (n = 5) were fed control diet; Zucker diabetic fatty rats (n = 5/group) were fed either an AIN-93G control diet (DC) or AIN-93G diet containing either 10% RS or 20% RS (HRS) for 6 weeks...
April 2016: Nutrition Research
https://www.readbyqxmd.com/read/26934010/-nephrotic-syndrome-in-adult-patients-etiology-and-complications
#14
REVIEW
Harald Seeger, Thomas Fehr
The nephrotic syndrome (NS) in adult patients is a rare entity. It is characterized by a tetrad consisting of edema, proteinuria, hypoalbuminemia and hypercholesterolemia. NS can be caused by intrinsic glomerular disorders or secondary damage to the glomerulus triggered by systemic diseases, infections or drugs. The responsibility of the primary care physician is to distinguish NS from other edematous disorders. Patients should be referred to a nephrologist for further diagnosis and treatment. NS is associated with various complications...
March 2, 2016: Praxis
https://www.readbyqxmd.com/read/26851346/1-25-vitamin-d3-deficiency-induces-albuminuria
#15
Ramon Sonneveld, Joost G J Hoenderop, Andrea W D Stavenuiter, Evelina Ferrantelli, Marijke P A Baltissen, Henry B Dijkman, Sandrine Florquin, Angelique L Rops, Jack F M Wetzels, Jo H M Berden, Johan van der Vlag, Tom Nijenhuis
Vitamin D plays an important role in renal (patho)physiology. Patients with glomerular diseases have an injured renal filtration barrier, leading to proteinuria and reduced renal function. An impaired renal function also leads to 1,25-vitamin D3 deficiency as a result of reduced renal 1α-hydroxylase activity. Vitamin D treatment to reduce proteinuria remains controversial, although there is an inverse correlation between vitamin D levels and proteinuria. Herein, we showed that 1,25-vitamin D3-deficient 25-hydroxy-vitamin-D3-1α-hydroxylase knockout mice and 1,25-vitamin D3-deficient rats develop podocyte injury and renal dysfunction...
April 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/26798466/drug-induced-fanconi-syndrome-associated-with-fumaric-acid-esters-treatment-for-psoriasis-a-case-series
#16
Deepak M W Balak, Jan Nico Bouwes Bavinck, Aiko P J de Vries, Jenny Hartman, Hendrik A Martino Neumann, Robert Zietse, Hok Bing Thio
BACKGROUND: Fumaric acid esters (FAEs), an oral immunomodulating treatment for psoriasis and multiple sclerosis, have been anecdotally associated with proximal renal tubular dysfunction due to a drug-induced Fanconi syndrome. Few data are available on clinical outcomes of FAE-induced Fanconi syndrome. METHODS: Descriptive case series with two cases of Fanconi syndrome associated with FAE treatment diagnosed at two Dutch university nephrology departments, three cases reported at the Dutch and German national pharmacovigilance databases and six previously reported cases...
February 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/26640388/vitamin-d-status-and-cholecalciferol-supplementation-in-chronic-kidney-disease-patients-an-italian-cohort-report
#17
Adamasco Cupisti, Valentina Vigo, Maria Enrica Baronti, Claudia D'Alessandro, Lorenzo Ghiadoni, Maria Francesca Egidi
This study investigated the factors associated with hypovitaminosis D, in a cohort of 405 prevalent patients with chronic kidney disease (CKD) stages 2-4, living in Italy and followed-up in tertiary care. The effect of cholecalciferol 10,000 IU once-a-week for 12 months was evaluated in a subgroup of 100 consecutive patients with hypovitaminosis D. Vitamin D deficiency was observed in 269 patients (66.4%) whereas vitamin D insufficiency was found in 67 patients (16.5%). In diabetic patients, 25-hydroxyvitamin D deficiency was detected in 80% of cases...
2015: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/26602143/quantitation-of-25-oh-vitamin-d%C3%A2-and-25-oh-vitamin-d%C3%A2-in-urine-using-lc-ms-ms
#18
Dean C Carlow, Ryan C Schofield, Michelle Denburg
Patients with significant proteinuria represent a unique population with respect to vitamin D status due to the urinary losses of vitamin D-binding protein (DBP) to which >99 % of circulating 25-hydroxy vitamin D (25(OH)D) is bound. Low serum concentrations of 25(OH)D have been found in children and adults with nephrotic syndrome (NS). However, previously described assays developed to quantify the magnitude of urinary loss are technically challenging. This chapter describes a simple and sensitive method to quantify 25(OH)D2 and 25(OH)D3 in urine specimens in a single analytical LC-MS/MS analysis...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/26545084/tenofovir-monotherapy-for-hepatitis-b-after-1-year-does-not-produce-renal-dysfunction-but-is-associated-with-hyperparathyroidism-not-related-to-vitamin-d
#19
Jose A Patricio, Patricia F Lopes, Thalia Medeiros, Guilherme F Mendes, Andrea A Silva, Eliane B Esberard, Jocemir R Lugon, Jorge R Almeida
INTRODUCTION: Viral hepatitis B (VHB) represents a major public health problem. Studies from HIV multidrug patients have associated the use of tenofovir disoproxil fumarate (TDF) with renal dysfunction and phosphate wasting. OBJECTIVE: The aim of this study was to examine the effect of year-long TDF monotherapy on renal function in VHB patients. PATIENTS AND METHODS: We evaluated adult patients diagnosed with VHB before treatment initiation (T0), and after 3 and 12 months (T3 and T12) of TDF initiation...
January 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/26451144/role-of-paricalcitol-in-modulating-the-immune-response-in-patients-with-renal-disease
#20
Silvia Lucisano, Adriana Arena, Giovanna Stassi, Daniela Iannello, Gaetano Montalto, Adolfo Romeo, Giuseppe Costantino, Rosaria Lupica, Valeria Cernaro, Domenico Santoro, Michele Buemi
Introduction. The aim was to highlight the existence of a relationship between vitamin D deficiency, chronic inflammation, and proteinuria, by measuring neutrophil gelatinase associated lipocalin (NGAL) and common inflammatory markers after administration of paricalcitol, a vitamin D analog, in vivo and in vitro. Methods. 40 patients with end-stage chronic kidney disease (CKD) and secondary hyperparathyroidism and 40 healthy subjects were enrolled. Serum calcium, phosphorus, 25(OH)-vitamin D, parathyroid hormone (PTH), erythrocyte sedimentation rate, high-sensitivity C-reactive protein, interleukin- (IL-) 17, IL-6, IL-1β, interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), plasmatic and urinary NGAL, and 24 h albuminuria and proteinuria were measured before and 24 h after an intravenous bolus of paricalcitol (5 mcg)...
2015: International Journal of Endocrinology
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