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https://www.readbyqxmd.com/read/29661746/effects-of-oral-vitamin-d-3-supplementation-in-stage-3-chronic-kidney-disease-subjects-insulin-resistance-syndrome-and-hormonal-disturb-interactions
#1
Amina Tahar, Faiza Zerdoumi, Messaoud Saidani, Lakhdar Griene, Elhadj-Ahmed Koceir
The 1-25-hydroxyvitamine D (1-25OHD) or calcitriol deficiency in chronic kidney disease (CKD) patients was associated with increases vascular calcification risk, nephrons reduction, bone deficit and cardiovascular mortality by atherosclerosis. The objective of this study was to investigate the pleiotropic effects of 200.000 IU (D200 group) every 3 months versus 30.000 IU (D30 group) every month dose vitamin D supplementation in stage 3 CKD patients. A cohort of 132 adult subjects was randomized into 2 groups according to dose vitamin D supplementation in deficient subjects (25OHD <50 nmol/L or <20 ng/mL)...
April 16, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29648479/dietary-intervention-and-health-in-patients-with-systemic-lupus-erythematosus-a-systematic-review-of-the-evidence
#2
Marília Cristina Santos de Medeiros, Jussara Cristina Alves Medeiros, Humberto Jefferson de Medeiros, José Carlos Gomes de Carvalho Leitão, Maria Irany Knackfuss
OBJECTIVE: The aim of this study was to evaluate the scientific evidence of dietary intervention, either through diet or supplementation, and its effects on the health of patients with systemic lupus erythematosus. METHODS: Literature searches were conducted using Scopus, PubMed, BioMed Central and Science Direct databases. The terms used for the search were diet, nutritional support, nutrition therapy and systemic lupus erythematosus. RESULTS: Eleven studies with interventions related to supplementation of omega-3 fatty acids, vitamin D and turmeric, as well as changes in diet composition, such as low glycaemic index diet were identified...
April 12, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29588145/vitamin-d-deficiency-and-pre-eclampsia-in-colombia-previtd-study
#3
Norma C Serrano, Elizabeth Guío, Doris C Quintero-Lesmes, Silvia Becerra-Bayona, Maria L Luna-Gonzalez, Victor M Herrera, Carlos E Prada
PURPOSE: Pre-eclampsia is a multisystem disorder characterized by new-onset hypertension and proteinuria during pregnancy. Pre-eclampsia remains a major cause of maternal death in low-income countries. Vitamin D has a very diverse biological role in cardiovascular diseases. This study will evaluate the association of vitamin D levels and relevance to pre-eclampsia. METHODS: We conducted a case-control study of women recruited from the GenPE (Genetics and Pre-eclampsia) Colombian registry...
March 14, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29545131/-utilization-of-alfacalcidol-and-active-vitamin-d-analogs-in-chronic-kidney-disease
#4
Pablo Antonio Ureña-Torres, Mario Cozzolino, Jordi Bover
Secondary hyperparathyroidism (SHPT) is one of the most frequent and deleterious complication of chronic kidney disease (CKD). SHPT is also one of the principal components of the now called CKD-mineral and bone disorders (MBD) syndrome. It is usually prevented and treated by vitamin D derivatives. However, the rationale for the prescription of vitamin D sterols in those patients is still a matter of hotly debates, mainly because of unsatisfactory results from numerous observational and not well-controlled studies...
March 12, 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29484540/vitamin-d-supplementation-improves-endothelial-dysfunction-in-patients-with-non-dialysis-chronic-kidney-disease
#5
Qingyan Zhang, Miao Zhang, Hengjin Wang, Cheng Sun, Yuan Feng, Wei Zhu, Dongwei Cao, Qiuyuan Shao, Nan Li, Yangyang Xia, Tianfeng Tang, Cheng Wan, Jing Liu, Bo Jin, Min Zhao, Chunming Jiang
PURPOSE: Hypovitaminosis D is common in chronic kidney disease (CKD) and is associated with endothelial dysfunction and cardiovascular events. This study aimed to investigate the effects of vitamin D supplementation on endothelial dysfunction in non-dialysis CKD patients. MATERIALS AND METHODS: Seventy-one non-dialysis CKD patients with low vitamin D (serum 25(OH)D < 30 ng/mL) were recruited. Patients received oral cholecalciferol 50,000 units once a week for 12 weeks...
February 26, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29466283/the-relationship-between-maternal-nutrition-during-pregnancy-and-offspring-kidney-structure-and-function-in-humans-a-systematic-review
#6
REVIEW
Yu Qi Lee, Clare E Collins, Adrienne Gordon, Kym M Rae, Kirsty G Pringle
The intrauterine environment is critical for fetal growth and organ development. Evidence from animal models indicates that the developing kidney is vulnerable to suboptimal maternal nutrition and changes in health status. However, evidence from human studies are yet to be synthesised. Therefore, the aim of the current study was to systematically review current research on the relationship between maternal nutrition during pregnancy and offspring kidney structure and function in humans. A search of five databases identified 9501 articles, of which three experimental and seven observational studies met the inclusion criteria...
February 21, 2018: Nutrients
https://www.readbyqxmd.com/read/29386413/effect-of-vitamin-d-therapy-on-urinary-albumin-excretion-renal-functions-and-plasma-renin-among-patients-with-diabetic-nephropathy-a-randomized-double-blind-clinical-trial
#7
Plgc Liyanage, S Lekamwasam, T P Weerarathna, C Liyanage
BACKGROUND: Despite different management strategies, progression of proteinuria occurs in a sizable category of patients with diabetic nephropathy (DN). Increase in serum renin levels induced by the renin-angiotensin system (RAS) may contribute to this. Vitamin D therapy is found to have an inhibitory effect on the RAS. We aimed to study the effects of Vitamin D therapy on renal functions of patients with DN. METHODS: This was a double-blind, randomized, placebo-controlled study...
January 2018: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/29355168/reproductive-health-and-pregnancy-in-women-with-chronic-kidney-disease
#8
REVIEW
Kate S Wiles, Catherine Nelson-Piercy, Kate Bramham
Chronic kidney disease (CKD) is associated with reduced fertility and an increased risk of adverse pregnancy outcomes. Rates of pre-eclampsia, fetal growth restriction and preterm delivery increase incrementally with the severity of CKD and proteinuria. Pre-pregnancy counselling can facilitate informed decision-making. Safe and effective contraception is required for women who wish to delay or avoid pregnancy. Pregnancy planning for women who wish to conceive involves appropriate substitution of known teratogens - including mycophenolate mofetil, angiotensin blockers and cyclophosphamide - and can aid optimization of disease control...
March 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29345464/whole-egg-consumption-exerts-a-nephroprotective-effect-in-an-acute-rodent-model-of-type-1-diabetes
#9
Cassondra J Saande, Samantha K Jones, Matthew J Rowling, Kevin L Schalinske
Nephropathy is a well-characterized complication of type 1 diabetes (T1D), resulting in proteinuria and urinary loss of micronutrients. We previously found that a whole egg-based diet maintained vitamin D balance in type 2 diabetic rats despite excessive urinary losses due to nephropathy. The goal of this study was to investigate the impact of whole egg consumption in T1D rats. Sprague-Dawley rats were randomly assigned to T1D or nondiabetic control groups and fed a casein or whole egg-based diet for 32 days...
January 18, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29190607/effect-of-paricalcitol-on-bone-density-after-kidney-transplantation-analysis-of-2-transplant-centers
#10
Zuzana Žilinská, Ivana Dedinská, Ján Breza, Ludovít Laca
INTRODUCTION: The Kidney Disease: Improving Global Outcomes Clinical Practice Guidelines on the management of bone disease in patients with chronic kidney disease recommend periodic measurement of serum calcium, phosphorus, vitamin D, and parathyroid hormone levels after kidney transplantation, with the frequencies that will vary according to the severity of bone disease and graft function. Paricalcitol, a selective vitamin D receptor activator, is indicated in the prevention and treatment of secondary hyperparathyroidism...
November 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29169714/-idiopathic-nephrotic-syndrome
#11
O Boyer, V Baudouin, E Bérard, C Dossier, V Audard, V Guigonis, I Vrillon
Nephrotic syndrome (NS) is defined by massive proteinuria and hypoalbuminemia, with resulting hyperlipidemia and edema. The most common cause of NS in children is idiopathic nephrotic syndrome (INS), also called nephrosis. Its annual incidence has been estimated to 1-4 per 100,000 children and varies with age, race, and geography. Many agents or conditions have been reported to be associated with INS such as infectious diseases, drugs, allergy, vaccinations, and malignancies. The disease may occur during the 1st year of life, but it usually starts between the ages of 2 and 7 years...
December 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29104461/serum-1-25-dihydroxyvitamin-d-better-reflects-renal-parameters-than-25-hydoxyvitamin-d-in-patients-with-glomerular-diseases
#12
Sungjin Chung, Minyoung Kim, Eun Sil Koh, Hyeon Seok Hwang, Yoon Kyung Chang, Cheol Whee Park, Suk Young Kim, Yoon Sik Chang, Yu Ah Hong
Background: Impaired vitamin D metabolism may contribute to the development and progression of chronic kidney disease. The purpose of this study was to determine associations of circulating vitamin D with the degree of proteinuria and estimated glomerular filtration rate (eGFR) in patients with biopsy-proven glomerular diseases. Methods: Clinical and biochemical data including blood samples for 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2 D) levels were collected from patients at the time of kidney biopsy...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29067923/effect-of-vitamin-d-therapy-on-urinary-albumin-excretion-renal-functions-and-plasma-renin-among-patients-with-diabetic-nephropathy-a-randomized-double-blind-clinical-trial
#13
Plgc Liyanage, S Lekamwasam, T P Weerarathna, C Liyanage
BACKGROUND: Despite different management strategies, progression of proteinuria occurs in a sizable category of patients with diabetic nephropathy (DN). Increase in serum renin levels induced by the renin-angiotensin system (RAS) may contribute to this. Vitamin D therapy is found to have an inhibitory effect on the RAS. We aimed to study the effects of Vitamin D therapy on renal functions of patients with DN. METHODS: This was a double-blind, randomized, placebo-controlled study...
October 23, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28981319/vitamin-d-supplementation-prevents-placental-ischemia-induced-endothelial-dysfunction-by-downregulating-placental-soluble-fms-like-tyrosine-kinase-1
#14
Su-Ling Ma, Xiao-Yu Tian, Ya-Qi Wang, Hui-Feng Zhang, Lei Zhang
Maternal vitamin D deficiency in pregnancy has been associated with an increased risk of preeclampsia. Vascular endothelial dysfunction is a major phenotype of pregnancies with preeclampsia, contributing to increased maternal hypertension and proteinuria. We sought to determine whether vitamin D supplementation would alleviate preeclampsia associated endothelial dysfunction and explore the underlying mechanism using the reduced uterine perfusion pressure (RUPP) rat model. RUPP operated rats were supplemented with 1,25(OH)2D (RUPP+VD) on day 1, 7, and 14 of pregnancy by subcutaneous injection...
October 5, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28975092/self-limited-membranous-nephropathy-after-intravitreal-bevacizumab-therapy-for-age-related-macular-degeneration
#15
Gebran Khneizer, Ahmad Al-Taee, Bahar Bastani
BACKGROUND: Monoclonal antibodies targeting vascular endothelial growth factor (VEGF), such as bevacizumab, are administered intravitreally for the treatment of wet or exudative age-related macular degeneration (ARMD). Systemic use of bevacizumab has been linked to a wide range of renal adverse effects including proteinuria and hypertension. CASE PRESENTATION: We present the case of a 77-year-old Caucasian male with a past medical history of hypertension, vitamin D deficiency and paroxysmal atrial fibrillation who presented to primary care clinic with a 2-week history of bilateral lower extremity edema, 2 months after completing four monthly intravitreal injections of bevacizumab for ARMD...
July 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28940158/vitamin-d-and-osteoporosis-in-chronic-kidney-disease
#16
REVIEW
Paul Lips, David Goldsmith, Renate de Jongh
Osteoporotic fractures are common in patients with chronic kidney disease (CKD). Morbidity and mortality are higher in CKD patients with a fracture than in the general population. The assessment of bone mineral density for fracture prediction may be useful at all CKD stages. It should be considered when this influences treatment decisions. Vitamin D deficiency is common in patients with CKD, particularly in patients with proteinuria, due to loss of 25-hydroxyvitamin D and its binding protein. Vitamin D supplementation should be prescribed early in the course of renal disease...
October 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28835982/effects-of-paricalcitol-on-cardiovascular-outcomes-and-renal-function-in-patients-with-chronic-kidney-disease-a-meta-analysis
#17
REVIEW
X Hu, J Shang, W Yuan, S Zhang, Y Jiang, B Zhao, Y Duan, J Xiao, Z Zhao
BACKGROUND: Paricalcitol, a selective activator of the vitamin D receptor (VDR), influences calcium and phosphorus homeostasis and bone metabolism. Whether paricalcitol reduces cardiovascular risk and protects renal function remains unclear. To systematically evaluate this in patients with chronic kidney disease (CKD), we conducted a meta-analysis of published randomized controlled trials (RCTs). METHODS: We searched MEDLINE, Embase, the Cochrane Library, and reference lists for RCTs comparing paricalcitol with placebo in stage 2-5 CKD (including pre-dialysis and renal replacement patients)...
August 23, 2017: Herz
https://www.readbyqxmd.com/read/28815356/dent-disease-in-poland-what-we-have-learned-so-far
#18
Marcin Zaniew, Małgorzata Mizerska-Wasiak, Iga Załuska-Leśniewska, Piotr Adamczyk, Katarzyna Kiliś-Pstrusińska, Adam Haliński, Jan Zawadzki, Beata S Lipska-Ziętkiewicz, Krzysztof Pawlaczyk, Przemysław Sikora, Michael Ludwig, Maria Szczepańska
PURPOSE: Dent disease (DD) is a rare tubulopathy characterized by proximal tubular dysfunction leading to chronic kidney disease (CKD). The aim of the study was to characterize patients with DD in Poland. METHODS: A retrospective analysis of a national cohort with genetically confirmed diagnosis. RESULTS: Of 24 males, all patients except one carried mutations in the CLCN5 gene; in one patient a mutation in the OCRL gene was disclosed. Molecular diagnosis was delayed 1 year on average (range 0-21 years)...
November 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28664839/effects-of-paricalcitol-on-biomarkers-of-inflammation-and-fibrosis-in-kidney-transplant-recipients-results-of-a-randomized-controlled-trial
#19
Manca Oblak, Gregor Mlinšek, Aljoša Kandus, Jadranka Buturović-Ponikvar, Miha Arnol
AIMS: Paricalcitol, a selective vitamin D activator, decreases proteinuria and may reduce graft failure risk in kidney transplant recipients. In this study, we evaluated the effect of paricalcitol on renin-angiotensin system (RAS) activity as well as interleukin (IL)-6 and transforming growth factor (TGF)-β plasma concentrations as biomarkers of inflammation and fibrosis. METHODS: This placebo-controlled, double-blind trial enrolled a national cohort of kidney transplant recipients with urinary protein-to-creatinine ratio (UPCR) ≥ 20 mg/mmol despite optimization of the RAS blockade...
2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28592350/vitamin-d-status-in-renal-transplant-recipients-living-in-a-low-latitude-city-association-with-body-fat-cardiovascular-risk-factors-estimated-glomerular-filtration-rate-and-proteinuria
#20
Kelli T C Rosina, Ana Paula M Menna Barreto, Karine S S Pontes, Cyro J M Martins, Edison Souza, Rachel Bregman, Maria Inês Barreto Silva, Márcia R S T Klein
Recent evidence suggests that vitamin D deficiency is associated with CVD, impaired kidney function and proteinuria. To date, no study has evaluated these associations in renal transplant recipients (RTR) adjusting for body adiposity assessed by a 'gold standard' method. This study aimed to evaluate the vitamin D status and its association with body adiposity, CVD risk factors, estimated glomerular filtration rate (eGFR) and proteinuria in RTR, living in Rio de Janeiro, Brazil (a low-latitude city (22°54'10"S)), taking into account body adiposity evaluated by dual-energy X-ray absorptiometry (DXA)...
May 2017: British Journal of Nutrition
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