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https://www.readbyqxmd.com/read/28346614/crosstalk-between-transforming-growth-factor-beta-2-and-toll-like-receptor-4-in-the-trabecular-meshwork
#1
Humberto Hernandez, Wanda E Medina-Ortiz, Tomi Luan, Abbot F Clark, Colleen M McDowell
Purpose: The trabecular meshwork (TM) is involved in the outflow of aqueous humor and intraocular pressure (IOP) regulation. Regulation of the extracellular matrix (ECM) by TGFβ2 signaling pathways in the TM has been extensively studied. Recent evidence has implicated toll-like receptor 4 (TLR4) in the regulation of ECM and fibrogenesis in liver, kidney, lung, and skin. Here, we investigated the role of TGFβ2-TLR4 signaling crosstalk in the regulation of the ECM in the TM and ocular hypertension...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28346337/a-smart-sensor-for-defending-against-clock-glitching-attacks-on-the-i2c-protocol-in-robotic-applications
#2
Raúl Jiménez-Naharro, Fernando Gómez-Bravo, Jonathan Medina-García, Manuel Sánchez-Raya, Juan Antonio Gómez-Galán
This paper presents a study about hardware attacking and clock signal vulnerability. It considers a particular type of attack on the clock signal in the I2C protocol, and proposes the design of a new sensor for detecting and defending against this type of perturbation. The analysis of the attack and the defense is validated by means of a configurable experimental platform that emulates a differential drive robot. A set of experimental results confirm the interest of the studied vulnerabilities and the efficiency of the proposed sensor in defending against this type of situation...
March 25, 2017: Sensors
https://www.readbyqxmd.com/read/28343747/unilateral-uveitis-associated-with-iga-nephropathy
#3
T Rueda-Rueda, J L Sánchez-Vicente, A Moruno-Rodríguez, F E Molina-Socola, M Contreras-Díaz, L Vizuete-Rodríguez, M Castilla-Martino, L Sáez-Ortega, A Muñoz-Morales, A C Martínez-Borrego, E Parra-Oviedo, A Medina-Tapia, F López-Herrero
CASE REPORT: The case is presented of a 42 year-old man with episodes of unilateral uveitis in his right eye. Ophthalmic examination showed a granulomatous anterior uveitis with vitritis. Systemic investigations revealed non-nephrotic proteinuria and microhaematuria. A renal biopsy showed IgA nephropathy. DISCUSSION: Uveitis and glomerulonephritis may have common immunological pathogenesis. IgA nephropathy should be a differential diagnosis in patients with uveitis and nephropathy...
March 23, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28342567/ocular-ultrasound-in-a-patient-with-vitreous-haemorrhage-caused-by-a-retinal-tear
#4
F López-Herrero, J L Sánchez-Vicente, F E Molina-Sócola, A Medina-Tapia, N Seva-Silva
No abstract text is available yet for this article.
March 22, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28341998/ire1-signaling-exacerbates-alzheimer-s-disease-pathogenesis
#5
Claudia Duran-Aniotz, Victor Hugo Cornejo, Sandra Espinoza, Álvaro O Ardiles, Danilo B Medinas, Claudia Salazar, Andrew Foley, Ivana Gajardo, Peter Thielen, Takao Iwawaki, Wiep Scheper, Claudio Soto, Adrian G Palacios, Jeroen J M Hoozemans, Claudio Hetz
Altered proteostasis is a salient feature of Alzheimer's disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress and abnormal protein aggregation. ER stress triggers the activation of the unfolded protein response (UPR), a signaling pathway that enforces adaptive programs to sustain proteostasis or eliminate terminally damaged cells. IRE1 is an ER-located kinase and endoribonuclease that operates as a major stress transducer, mediating both adaptive and proapoptotic programs under ER stress...
March 24, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28341845/the-trimer-interface-in-the-quaternary-structure-of-the-bifunctional-prokaryotic-fad-synthetase-from-corynebacterium-ammoniagenes
#6
Ana Serrano, María Sebastián, Sonia Arilla-Luna, Silvia Baquedano, Beatriz Herguedas, Adrián Velázquez-Campoy, Marta Martínez-Júlvez, Milagros Medina
Bifunctional FAD synthetases (FADSs) fold in two independent modules; The C-terminal riboflavin kinase (RFK) catalyzes the RFK activity, while the N-terminal FMN-adenylyltransferase (FMNAT) exhibits the FMNAT activity. The search for macromolecular interfaces in the Corynebacterium ammoniagenes FADS (CaFADS) crystal structure predicts a dimer of trimers organization. Within each trimer, a head-to-tail arrangement causes the RFK and FMNAT catalytic sites of the two neighboring protomers to approach, in agreement with active site residues of one module influencing the activity at the other...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28341024/-biochemical-basis-of-tolerance-to-osmotic-stress-in-phytopathogenic-fungus-the-case-of-macrophomina-phaseolina-tassi-goid
#7
Rodolfo Martínez-Villarreal, Tamar S Garza-Romero, Víctor R Moreno-Medina, Sanjuana Hernández-Delgado, Netzahualcoyotl Mayek-Pérez
Fungus Macrophomina phaseolina (Tassi) Goid. is the causative agent of charcoal rot disease which causes significant yield losses in major crops such as maize, sorghum, soybean and common beans in Mexico. This fungus is a facultative parasite which shows broad ability to adapt itself to stressed environments where water deficits and/or high temperature stresses commonly occur. These environmental conditions are common for most cultivable lands throughout Mexico. Here we describe some basic facts related to the etiology and epidemiology of the fungus as well as to the importance of responses to stressed environments, particularly to water deficits, based on morphology and growth traits, as well as on physiology, biochemistry and pathogenicity of fungus M...
October 2016: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28339995/long-term-flecainide-therapy-in-type-3-long-qt-syndrome
#8
Ehud Chorin, Rivki Taub, Aron Medina, Nir Flint, Sami Viskin, Jesaia Benhorin
Aims: Type 3 long QT syndrome (LQT3) is caused by gain-of-function mutations in the cardiac sodium channel gene (SCN5A). Previous reports on the long-term use of sodium channel blockers in LQT3 are sparse. The objective of the current study was to evaluate the long-term safety and efficacy of flecainide therapy in patients with LQT3 who carry the D1790G SCN5A mutation. Methods and results: The study population comprised 30 D1790G carriers who were treated with flecainide and followed for 1-215 months (mean 145 ± 54 months, median 140 months)...
February 28, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28335081/the-impact-of-body-mass-index-and-nuclear-%C3%AE-catenin-on-survival-in-locally-advanced-rectal-cancer-treated-with-preoperative-radiochemotherapy
#9
Jaime Gomez-Millan, Maria Isabel Queipo, Maria Del Mar Delgado, Lidia Perez-Villa, Alicia Roman, Fernando De la Portilla, Esperanza Torres, Vanessa De Luque, Eloisa Bayo, Jose Antonio Medina
BACKGROUND AND OBJECTIVE: We examined the prognostic value of obesity and nuclear β-catenin in patients with locally advanced rectal cancer. METHODS: We prospectively recruited a total of 98 eligible patients with locally advanced cancer for preoperative radiochemotherapy followed by total mesorectal excision. Patients' height and weight were reaorded before radiochemotherapy, and the immunohistochemical expression of nuclear β-catenin was analyzed. Disease-free survival (DFS) was analyzed using the Kaplan-Meier method and a Cox regression model was employed for the multivariate analysis...
March 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28334623/rapid-on-chip-apoptosis-assay-on-human-carcinoma-cells-based-on-annexin-v-quantum-dot-probes
#10
Helena Montón, Mariana Medina-Sánchez, Joan Antoni Soler, Andrzej Chałupniak, Carme Nogués, Arben Merkoçi
Despite all the efforts made over years to study the cancer expression and the metastasis event, there is not a clear understanding of its origins and effective treatment. Therefore, more specialized and rapid techniques are required for studying cell behaviour under different drug-based treatments. Here we present a quantum dot signalling-based cell assay carried out in a segmental microfluidic device that allows studying the effect of anti-cancer drugs in cultured cell lines by monitoring phosphatidylserine translocation that occurs in early apoptosis...
March 18, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28334331/alterations-of-immune-parameters-on-trichoplusia-ni-lepidoptera-noctuidae-larvae-exposed-to-extremely-low-frequency-electromagnetic-fields
#11
Jose A Valadez-Lira, Nahui O Medina-Chavez, Alonso A Orozco-Flores, J Antonio Heredia-Rojas, Abraham O Rodriguez-de la Fuente, Ricardo Gomez-Flores, Juan M Alcocer-Gonzalez, Patricia Tamez-Guerra
Worldwide mobile telephone and microwave use have resulted in an increasing presence of extremely low-frequency electromagnetic field radiations (ELF-EMFs) in ecosystems. ELF-EMFs have been associated with altered physiological processes that can adversely affect exposed organisms. In this study, Trichoplusia ni Hübner larvae were exposed for 24, 48, or 72 h to ELF-EMFs (60 Hz and 2.0 mT) to assess effects on immune response parameters and fertility. Trichoplusia ni life cycle and fertility were not affected by 24-h exposure...
March 6, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28333775/pigmented-villonodular-synovitis-of-the-temporomandibular-joint-with-petrous-bone-invasion
#12
Miguel Vaca, Ruben Polo, Juan Martínez-San-Millán, Maria Eugenia Reguero, Cecilia Pérez, Adela Cordero, Maria Del Mar Medina, Ignacio Cobeta
No abstract text is available yet for this article.
March 22, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28332036/the-committed-intimate-partnerships-of-incarcerated-african-american-men-implications-for-sexual-hiv-transmission-risk-and-prevention-opportunities
#13
Maria R Khan, Nabila El-Bassel, Carol E Golin, Joy D Scheidell, Adaora A Adimora, Ashley M Coatsworth, Hui Hu, Selena Judon-Monk, Katie P Medina, David A Wohl
Incarceration is thought to influence HIV transmission by disrupting partnerships that provide support and protect against sex risk-taking. Current correctional facility-based family-strengthening programs focus on marital partnerships, a minority of inmates' partnerships. Research on the sex partnerships of incarcerated African-American men and the types of partnerships most likely to protect against HIV-related sex risk is limited. Improved understanding can inform expansion of correctional facility-based family-strengthening programs to a greater proportion of protective partnerships and HIV risk reduction programs to partnerships vulnerable to sex risk...
March 22, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28330562/zinc-biofortification-improves-phytochemicals-and-amino-acidic-profile-in-brassica-oleracea-cv-bronco
#14
Yurena Barrameda-Medina, Begoña Blasco, Marco Lentini, Sergio Esposito, Nieves Baenas, Diego A Moreno, Juan M Ruiz
Zn deficiency is currently listed as a major risk factor for human health. Recently, a complimentary solution to mineral malnutrition termed 'biofortification' has been proposed. The aim of this study was to investigate the possible effects of a Zn-biofortification program on Zn levels, amino acidic profile and the phytochemicals content in an edible leafy vegetable, such as Brassica oleracea cv. Bronco. Our results indicate that supplementation of 80-100μM Zn is optimal for maintaining the normal growth of plants and to promote the major Zn concentration in the edible part of B...
May 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28325681/alcohol-cannabis-and-other-drugs-and-subsequent-suicide-ideation-and-attempt-among-young-mexicans
#15
Guilherme Borges, Corina Benjet, Ricardo Orozco, Maria-Elena Medina-Mora, David Menendez
OBJECTIVE: To report results from a follow-up study of alcohol, cannabis and other drugs on suicidal behavior. METHOD: We estimated prospective associations of substance use as a risk factor for incident suicide ideation and attempt, from a follow-up conducted in 2013 (n = 1071) of the original Mexican Adolescent Mental Health Survey conducted in 2005. RESULTS: Cannabis use before age 15 (ideation risk ratio (RR) = 3.97; 95% confidence interval (CI) = 1...
March 1, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28323360/spermatozoa-as-functional-components-of-robotic-microswimmers
#16
REVIEW
Veronika Magdanz, Mariana Medina-Sánchez, Lukas Schwarz, Haifeng Xu, Jens Elgeti, Oliver G Schmidt
In recent years, the combination of synthetic micro- and nanomaterials with spermatozoa as functional components has led to the development of tubular and helical spermbots - microrobotic devices with potential applications in the biomedical and nanotechnological field. Here, the initial advances in this field are discussed and the use of spermatozoa as functional parts in microdevices elaborated. Besides the potential uses of these hybrid robotic microswimmers, the obstacles along the way are discussed, with suggestions for solutions of the encountered challenges also given...
March 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28323202/enhanced-structural-connectivity-within-a-brain-sub-network-supporting-working-memory-and-engagement-processes-after-cognitive-training
#17
Francisco J Román, Yasser Iturria-Medina, Kenia Martínez, Sherif Karama, Miguel Burgaleta, Alan C Evans, Susanne M Jaeggi, Roberto Colom
The structural connectome provides relevant information about experience and training-related changes in the brain. Here, we used network-based statistics (NBS) and graph theoretical analyses to study structural changes in the brain as a function of cognitive training. Fifty-six young women were divided in two groups (experimental and control). We assessed their cognitive function before and after completing a working memory intervention using a comprehensive battery that included fluid and crystallized abilities, working memory and attention control, and we also obtained structural MRI images...
March 16, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28322700/increased-proinflammatory-cytokine-levels-in-prolonged-arthralgia-in-ross-river-virus-infection
#18
Dennis Tappe, José Vicente Pérez-Girón, Sergio Gómez-Medina, Stephan Günther, César Muñoz-Fontela, Jonas Schmidt-Chanasit
Ross River virus, a mosquitoborne alphavirus, causes epidemic polyarthritis in Australia and the Pacific region. We analyzed serum cytokine, chemokine, and growth factor levels in travelers returning to Germany from Australia. Serum samples showed elevated concentrations in the acute phase of the illness and, more pronounced, in the long-lasting convalescent phase.
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28322489/long-distance-movement-of-phosphate-starvation-responsive-micrornas-in-arabidopsis
#19
Amanda K Huen, Caren Rodriguez-Medina, Angela Y Y Ho, Craig A Atkins, Penelope M C Smith
Plant microRNAs are small RNAs that are important for genetic regulation of processes such as plant development or environmental responses. Specific microRNAs accumulate in the phloem during phosphate starvation, and may act as long-distance signalling molecules. We performed quantitative PCR on Arabidopsis hypocotyl micrograft tissues of wild-type and hen1-6 mutants to assess the mobility of several phosphate starvation-responsive microRNA species. In addition to the previously-confirmed mobile species miR399d, the corresponding microRNA* (miR399d*) was identified for the first time as mobile between shoots and roots...
March 21, 2017: Plant Biology
https://www.readbyqxmd.com/read/28322437/ethnic-racial-identity-and-friendships-in-early-adolescence
#20
Deborah Rivas-Drake, Adriana J Umaña-Taylor, David R Schaefer, Michael Medina
The current study examined how adolescents' ethnic-racial identity (ERI) informed the demographic diversity of their friendship network (Goal 1) and the extent of similarity between adolescents' and their friends' ERI (Goal 2). Participants were sixth and seventh grade students (N = 353; Mage  = 11.88, SD = .73; 50% girls; 29% African American, 31% White, 13% Latino) in the Midwestern U.S. Results from longitudinal cross-lagged models (Goal 1) indicated that having more diverse friendships at T2 was associated with greater T3 ERI exploration among all youth...
March 21, 2017: Child Development
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