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https://www.readbyqxmd.com/read/28927597/active-and-smart-biodegradable-packaging-based-on-starch-and-natural-extracts
#1
Carolina Medina-Jaramillo, Oswaldo Ochoa-Yepes, Celina Bernal, Lucía Famá
Active and smart biodegradable films from cassava starch and glycerol with 5wt.% of different natural extracts such as green tea and basil were obtained by casting. Their functional capacity as antioxidants and their physicochemical properties achieved from the incorporation of these types of extracts were evaluated. The content of phenolic compounds in the extracts led to films with significant antioxidant activity, being greater in the case of the system containing green tea extract. Color changes in both materials after immersion in different media (acid and basic) due to the presence of chlorophyll and carotenoids in the extracts were observed, but the film with basil extract reacted most notably to the different pH...
November 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28923676/histiocytic-and-dendritic-cell-neoplasms-a-case-series-of-24-patients
#2
Cristina Díaz Del Arco, Luis Ortega Medina, M Jesús Fernández Aceñero
No abstract text is available yet for this article.
September 15, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28923050/dry-needling-in-a-manual-physiotherapy-and-therapeutic-exercise-protocol-for-patients-with-chronic-mechanical-shoulder-pain-of-unspecific-origin-a-protocol-for-a-randomized-control-trial
#3
Emma Tejera-Falcón, Nuria Del Carmen Toledo-Martel, Francisco Manuel Sosa-Medina, Fátima Santana-González, Miriam Del Pino Quintana-de la Fe, Tomás Gallego-Izquierdo, Daniel Pecos-Martín
BACKGROUND: Shoulder pain of musculoskeletal origin is the main cause of upper limb pain of non-traumatic origin. Despite being one of the most common reasons for consultation, there is no established protocol for treatment due to the complexity of its etiology. However, it has been shown that the presence of myofascial trigger points on the shoulder muscles is a common condition associated with patients suffering from shoulder pain. This protocol has been created which describes the design of a randomized controlled trial to evaluate the effectiveness of the inclusion of dry needling (DN) within a protocol of manual physiotherapy and therapeutic exercise in the treatment of chronic shoulder pain of unspecific origin...
September 18, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28921414/multimedia-education-program-and-nutrition-therapy-improves-hba1c-weight-and-lipid-profile-of-patients-with-type-2-diabetes-a-randomized-clinical-trial
#4
Lubia Velázquez-López, Abril Violeta Muñoz-Torres, Patricia Medina-Bravo, Jenny Vilchis-Gil, Miguel Klϋnder-Klϋnder, Jorge Escobedo-de la Peña
PURPOSE: To evaluate the effect of a multimedia education program and nutrition therapy on metabolic control in patients with type 2 diabetes. RESEARCH QUESTION: What is the effect of a multimedia education program and nutritional therapy on metabolic control in type 2 diabetes? PATIENTS AND METHODS: A randomized clinical trial was conducted in 351 patients randomly assigned to either an experimental group receiving a multimedia diabetes education program (MDE) and nutrition therapy (NT) (NT + MDE: n = 173), or to a control group who received nutrition therapy only (NT: n = 178)...
September 18, 2017: Endocrine
https://www.readbyqxmd.com/read/28918545/increased-postharvest-life-of-tomlox-b-silenced-mutants-of-tomato-solanum-lycopersicum-var-ta234
#5
Elizabeth León-García, Gilber Vela-Gutiérrez, Oscar A Del Ángel-Coronel, Cristobal Torres-Palacios, Javier De La Cruz-Medina, Miguel A Gómez-Lim, Hugo Sergio García
A healthy lifestyle includes fruits and vegetables consumption. Tomato is one of the most consumed vegetables, although it is susceptible to physical damage through postharvest handling, thus leading to important losses. Softening is an important variable during tomato ripening; excessive softening is undesirable and leads to postharvest losses. TomloxB plays an important role in ripening, mainly in the loss of cellular integrity caused by fatty acids released from the lipid matrix of membranes that initiate oxidative deterioration, which is in turn carried into senescence...
September 16, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28918450/clinical-utility-of-the-asdas-index-in-comparison-with-basdai-in-patients-with-ankylosing-spondylitis-axis-study
#6
Agustí Sellas I Fernandez, Xavier Juanola Roura, Alberto Alonso Ruiz, José Rosas, Julio Medina Luezas, Eduardo Collantes Estevez, Miguel Ángel Abad Hernández, Virginia Carrasco Benitez, Cesar Fisac
The objective of the study was to study the clinical utility of the Ankylosing Spondylitis Disease Activity Score (ASDAS) for the assessment of disease activity in ankylosing spondylitis (AS) patients, compared to the Bath Ankylosing Spondylitis Activity Index (BASDAI). This was a prospective longitudinal observational study in patients with AS (NY-modified criteria) from 23 Spanish centers. Physical and analytical data; global, lumbar, and nocturnal pain; ASDAS, BASDAI and minimally acceptable clinical status (PASS) were collected...
September 16, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28918045/cationic-nanoliposomes-meet-mrna-efficient-delivery-of-modified-mrna-using-hemocompatible-and-stable-vectors-for-therapeutic-applications
#7
Tatjana Michel, Daniel Luft, Meike-Kristin Abraham, Sabrina Reinhardt, Martha L Salinas Medina, Julia Kurz, Martin Schaller, Meltem Avci-Adali, Christian Schlensak, Karlheinz Peter, Hans Peter Wendel, Xiaowei Wang, Stefanie Krajewski
Synthetically modified mRNA is a unique bioactive agent, ideal for use in therapeutic applications, such as cancer vaccination or treatment of single-gene disorders. In order to facilitate mRNA transfections for future therapeutic applications, there is a need for the delivery system to achieve optimal transfection efficacy, perform with durable stability, and provide drug safety. The objective of our study was to comprehensively analyze the use of 3β-[N-(N',N'-dimethylaminoethane) carbamoyl](DC-Cholesterol)/dioleoylphosphatidylethanolamine (DOPE) liposomes as a potential transfection agent for modified mRNAs...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28917708/type-2-diabetes-mellitus-balb-c-mice-are-more-susceptible-to-granulomatous-amoebic-encephalitis-immunohistochemical-study
#8
Maritza Omaña-Molina, Raquel Sanchez-Rocha, Dolores Hernandez-Martinez, Miriam Romero Grijalva, Citlaltepetl Salinas-Lara, Miriam Rodriguez-Sosa, Imelda Juarez-Avelar, Lizbeth Salazar-Villatoro, Arturo Gonzalez-Robles, Adolfo Rene Mendez-Cruz, Patricia Aley-Medina, Jesus Espinosa-Villanueva, Ismael Castelan-Ramirez, Jacob Lorenzo-Morales
Granulomatous amoebic encephalitis (GAE) is a chronic, difficult to resolve infection caused by amphizoic amoebae of the genus Acanthamoeba, which in most cases occurs in immunosuppressed persons or with chronic diseases such as diabetes. In this study, we describe the early events of A. culbertsoni infection of GAE in diabetic mice model. Diabetes was induced in male BALB/c mice, with a dose of streptozotocin (130 mg/kg). Healthy and diabetic mice were inoculated via intranasal with 1 × 10(6) trophozoites of A...
September 13, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28917638/novel-antihelmintic-activity-of-tinidazole-coordination-compounds-relevance-of-the-metal-ion-and-structural-properties
#9
Israel Alfaro-Fuentes, Rodrigo Castro-Ramírez, Naytzé Ortiz-Pastrana, Rosa María Medina-Guerrero, Lilia Catherinne Soler-Jiménez, Irma Martínez-Rodríguez, Miguel Betancourt-Lozano, Leonardo Ibarra-Castro, Norah Barba-Behrens, Emma Josefina Fajer-Ávila
The in vitro and in vivo antihelmintic activity of cobalt(II), copper(II) and zinc(II) coordination compounds of tinidazole (tnz) were investigated in cultivated spotted rose snapper, infested with dactylogyrid monogeneans. The tinidazole coordination compounds [Co(tnz)2Cl2], [Co(tnz)2Br2], [Cu(tnz)2Cl2], [Cu(tnz)2Br2], [Zn(tnz)2Cl2] and [Zn(tnz)2Br2] were synthesized and spectroscopically characterized. Their molecular structures were determined by their single crystal X-ray diffraction. The metal ions presented distorted tetrahedral geometries, with an intramolecular bifurcated lone pair SO⋯π, from the sulfone group with the imidazolic ring, which contributed to the stability of the compounds in solid state and in solution...
August 30, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28915434/neutralization-of-viral-infectivity-by-zebrafish-c-reactive-protein-isoforms
#10
Melissa Bello-Perez, Alberto Falco, Regla Medina-Gali, Patricia Pereiro, Jose Antonio Encinar, Beatriz Novoa, Luis Perez, Julio Coll
This work explores the unexpected in vivo and in vitro anti-viral functions of the seven c-reactive protein (crp1-7) genes of zebrafish (Danio rerio). First results showed heterogeneous crp1-7 transcript levels in healthy wild-type zebrafish tissues and organs and how those levels heterogeneously changed not only after bacterial but also after viral infections, including those in adaptive immunity-deficient rag1(-/-) mutants. As shown by microarray hybridization and proteomic techniques, crp2/CRP2 and crp5/CRP5 transcripts/proteins were among the most modulated during in vivo viral infection situations including the highest responses in the absence of adaptive immunity...
September 12, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28915307/the-use-of-bone-morphogenetic-protein-in-spinal-transforaminal-lumbar-interbody-fusion-our-experience
#11
Eduardo Colom-Beauchamp, David Beaton-Comulada, Julio A Rodriguez, José C Pérez-López, José Montañez-Huertas, Enrique Escobar-Medina, José Massanet-Vollrath
OBJECTIVE: Since its introduction and FDA approval, rhBMP-2 has been adopted by spine surgeons as a substitute for ICBG in numerous spinal fusion techniques. As broad clinical use increased, reports on potential complications associated with rhBMP-2 also increased. We provide our experience with TLIF using rhBMP-2 or ICBG in an entirely Hispanic population. METHODS: This was a 2-year retrospective study of 67 patients, with 26 in the rhBMP-2 group and 41 in the ICBG group, who underwent TLIF...
September 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28915303/prevalence-of-functional-dentition-in-a-group-of-mexican-adult-males
#12
Mirna Minaya-Sánchez, Carlo Eduardo Medina-Solís, Juan Fernando Casanova-Rosado, Ana Alicia Vallejos-Sánchez, Alejandro José Casanova-Rosado, María de Lourdes Márquez-Corona, Martha Mendoza-Rodríguez, Gerardo Maupomé
OBJECTIVE: To determine the prevalence of functional dentition and associated periodontal variables in a sample of Mexican adult males. METHODS: A cross-sectional study of 161 policemen in Campeche, Mexico, was carried out. A clinical examination using an electronic probe was used to collect variables (dental plaque, periodontal pockets, gingival recession, suppuration, and bleeding on probing) on 6 periodontal sites (a maximum of 168 sites, excluding third molars)...
September 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28915064/the-immunopathologic-effects-of-mycoplasma-pneumoniae-and-cards-toxin-a-primate-model
#13
Diego J Maselli, Jorge L Medina, Edward G Brooks, Jacqueline J Coalson, Thirumalai R Kannan, Vicki T Winter, Molly Principe, Marianna P Cagle, Joel B Baseman, Peter H Dube, Jay I Peters
Mycoplasma pneumoniae infection has been linked to poor asthma outcomes. M. pneumoniae produces an ADP-ribosylating and vacuolating toxin called Community Acquired Respiratory Distress Syndrome (CARDS) toxin that has a major role in inflammation and airway dysfunction. The objective was to evaluate the immunopathological effects in primates exposed to M. pneumoniae or CARDS toxin. Thirteen baboons were exposed to M. pneumoniae or CARDS toxin. At day 7 and 14, bronchoalveolar lavage fluid was collected and analyzed for cell count, percent of each type of cell, CARDS toxin by PCR, CARDS toxin by antigen capture, eosinophilic cationic protein, and cytokine profiles...
September 15, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28913884/syntheses-and-properties-of-tin-containing-conjugated-heterocycles
#14
Sara Urrego-Riveros, Isabel-Maria Ramirez Y Medina, Jonas Hoffmann, Anne Heitmann, Anne Staubitz
Heterocycles that contain tin atoms can be aromatic in a similar sense to well-known aromatic compounds such as benzene or thiophene, but such examples are rare. However, due to the low-lying σ*-orbitals of the tin-substituent bond in stannoles, they are capable of σ* - π* conjugation in a way that is exclusive to heavier element containing heterocycles. This makes stannoles very interesting alternatives for purely organic heterocycles in material applications, in which optoelectronic properties are of interest...
September 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28913747/primary-sj%C3%A3-gren-s-syndrome-extraglandular-manifestations-and-hydroxychloroquine-therapy
#15
J Demarchi, S Papasidero, M A Medina, D Klajn, R Chaparro Del Moral, O Rillo, V Martiré, G Crespo, A Secco, A Catalan Pellet, C Amitrano, C Crow, C Asnal, P Pucci, F Caeiro, N Benzanquen, J P Pirola, M Mayer, F Zazzetti, S Velez, J Barreira, N Tamborenea, L Santiago, L Raiti
The use of hydroxychloroquine (HCQ) in Primary Sjögren's Syndrome (pSS) has been assessed in different studies over the last years, with conflicting results regarding its efficacy in sicca syndrome and extraglandular manifestations (EGM). The goal of this study was to compare the incidence rate of EGM in pSS patients with and without HCQ therapy.We performed a multicenter retrospective study, including patients with pSS (European classification criteria) with at least 1 year of follow-up. Subjects with concomitant fibromyalgia, autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosing cholangitis were excluded...
September 14, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28912016/arabidopsis-thaliana-mirnas-promote-embryo-pattern-formation-beginning-in-the-zygote
#16
Alma Armenta-Medina, Daniel Lepe-Soltero, Daoquan Xiang, Raju Datla, Cei Abreu-Goodger, C Stewart Gillmor
miRNAs are essential regulators of cell identity, yet their role in early embryo development in plants remains largely unexplored. To determine the earliest stage at which miRNAs act to promote pattern formation in embryogenesis, we examined a series of mutant alleles in the Arabidopsis thaliana miRNA biogenesis enzymes DICER-LIKE 1 (DCL1), SERRATE (SE), and HYPONASTIC LEAVES 1 (HYL1). Cellular and patterning defects were observed in dcl1, se and hyl1 embryos from the zygote through the globular stage of embryogenesis...
September 11, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28911204/enhanced-vulnerability-of-human-proteins-towards-disease-associated-inactivation-through-divergent-evolution
#17
Encarnación Medina-Carmona, Julian E Fuchs, Jose A Gavira, Noel Mesa-Torres, Jose L Neira, Eduardo Salido, Rogelio Palomino-Morales, Miguel Burgos, David J Timson, Angel L Pey
Human proteins are vulnerable towards disease-associated single amino acid replacements affecting protein stability and function. Interestingly, a few studies have shown that consensus amino acids from mammals or vertebrates can enhance protein stability when incorporated into human proteins. Here, we investigate yet unexplored relationships between the high vulnerability of human proteins towards disease-associated inactivation and recent evolutionary site-specific divergence of stabilizing amino acids. Using phylogenetic, structural and experimental analyses, we show that divergence from the consensus amino acids at several sites during mammalian evolution has caused local protein destabilization in two human proteins linked to disease: cancer-associated NQO1 and alanine:glyoxylate aminotransferase, mutated in primary hyperoxaluria type I...
September 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28910132/modified-african-ngoma-healing-ceremony-for-stress-reduction-a-pilot-study
#18
Ava LaVonne Vinesett, Riitta Rutanen Whaley, Cheryl Woods-Giscombe, Paul Dennis, Medina Johnson, Yin Li, Pline Mounzeo, Mabiba Baegne, Kenneth H Wilson
OBJECTIVE: Indigenous people's ceremonies using rhythm and dance have been used for countless generations throughout the world for healing, conflict resolution, social bonding, and spiritual experience. A previous study reported that a ceremony based on the Central African ngoma tradition was favorably received by a group of Americans. The present trial compared the effects of the modified ngoma ceremony (Ngoma) with those of mindfulness-based stress reduction (MBSR) in a randomized pilot study...
September 14, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28906559/characterization-of-micrornas-from-arabidopsis-galls-highlights-a-role-for-mir159-in-the-plant-response-to-the-root-knot-nematode-meloidogyne-incognita
#19
Clémence Medina, Martine da Rocha, Marc Magliano, Alizée Ratpopoulo, Benoît Revel, Nathalie Marteu, Virginie Magnone, Kevin Lebrigand, Javier Cabrera, Marta Barcala, Ana Cláudia Silva, Anthony Millar, Carolina Escobar, Pierre Abad, Bruno Favery, Stéphanie Jaubert-Possamai
Root knot nematodes (RKN) are root parasites that induce the genetic reprogramming of vascular cells into giant feeding cells and the development of root galls. MicroRNAs (miRNAs) regulate gene expression during development and plant responses to various stresses. Disruption of post-transcriptional gene silencing in Arabidopsis ago1 or ago2 mutants decrease the infection rate of RKN suggesting a role for this mechanism in the plant-nematode interaction. By sequencing small RNAs from uninfected Arabidopsis roots and from galls 7 and 14 d post infection with Meloidogyne incognita, we identified 24 miRNAs differentially expressed in gall as putative regulators of gall development...
September 14, 2017: New Phytologist
https://www.readbyqxmd.com/read/28906057/a-chemical-disruptor-of-the-clpx-chaperone-complex-attenuates-multiresistant-staphylococcus-aureus-virulence
#20
Christian Fetzer, Vadim S Korotkov, Robert Thänert, Kyu Myung Lee, Martin Neuenschwander, Jens Peter von Kries, Eva Medina, Stephan Axel Sieber
The Staphylococcus aureus ClpXP protease is an important regulator of cell homeostasis and virulence. Here we utilize a high-throughput screen against the ClpXP complex and identify a specific inhibitor of the ClpX chaperone that disrupts its oligomeric state. Synthesis of 34 derivatives revealed that the molecular scaffold is restrictive for diversification with only minor changes tolerated. Subsequent analysis of the most active compound revealed strong attenuation of S. aureus toxin production which was quantified via a customized MS-based assay platform...
September 14, 2017: Angewandte Chemie
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