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https://www.readbyqxmd.com/read/29786102/the-ucp2-866g-a-ala55val-and-ucp3-55c-t-polymorphisms-are-associated-with-premature-coronary-artery-disease-and-cardiovascular-risk-factors-in-mexican-population
#1
Ricardo Gamboa, Claudia Huesca-Gómez, Vanessa López-Pérez, Rosalinda Posadas-Sánchez, Guillermo Cardoso-Saldaña, Aida Medina-Urrutia, Juan Gabriel Juárez-Rojas, María Elena Soto, Carlos Posadas-Romero, Gilberto Vargas-Alarcón
We examined the role of UCP gene polymorphisms as susceptibility markers for premature coronary artery disease (pCAD). The UCP2 Ala55Val (C/T rs660339), UCP2 -866G/A (rs659366), and UCP3 -55C/T (rs1800849) polymorphisms were genotyped in 948 patients with pCAD, and 763 controls. The distribution of the UCP2 A55V (C/T rs660339) and UCP3 -55 (rs1800849) was similar in patients and controls. However, under a recessive model, the UCP2 -866 (rs659366) A allele was associated with increased risk of developing pCAD (OR = 1...
May 21, 2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29785785/metabolism-within-the-tumor-microenvironment-and-its-implication-on-cancer-progression-an-ongoing-therapeutic-target
#2
REVIEW
Ma Carmen Ocaña, Beatriz Martínez-Poveda, Ana R Quesada, Miguel Ángel Medina
Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed in the last years. However, tumor cells are not alone. A series of extracellular components and stromal cells, such as endothelial cells, cancer-associated fibroblasts, tumor-associated macrophages, and tumor-infiltrating T cells, surround tumor cells in the so-called tumor microenvironment (TME)...
May 22, 2018: Medicinal Research Reviews
https://www.readbyqxmd.com/read/29785741/intergroup-contact-attitudes-across-peer-networks-in-school-selection-influence-and-implications-for-cross-group-friendships
#3
Deborah Rivas-Drake, Muniba Saleem, David R Schaefer, Michael Medina, Robert Jagers
This study offers new insights into the power of peer networks for shaping intergroup relations in a diverse school. Data were drawn from a longitudinal study of sixth-eighth graders (N = 524; MageT1  = 11.87; 48% girls; 9% Asian American/Pacific Islander, 28% African American, 13% Latino, 1% Native American, 31% White, 5% Other, and 11% Multiracial) in the Midwestern United States. Students with more positive intergroup contact attitudes (ICA) were most likely to be friends with similarly minded students...
May 22, 2018: Child Development
https://www.readbyqxmd.com/read/29782688/oral-yeast-colonization-in-patients-with-primary-and-secondary-sj%C3%A3-gren-s-syndrome
#4
Clarissa Castro Galvão Medeiros, Luiz Gustavo Dos Anjos Borges, Karen Cherubini, Fernanda Gonçalves Salum, Renata Medina da Silva, Maria Antonia Zancanaro de Figueiredo
OBJECTIVE: The study aimed to investigate the pattern of oral yeast colonization of Sjögren's syndrome patients and its correlation to salivary flow rates, age and time of the disease progression. MATERIALS AND METHODS: Saliva and swab specimens were obtained from 45 patients (primary Sjögren's syndrome= 15/ secondary Sjögren's syndrome= 15/ healthy controls= 15). Yeast species were identified using culture method through chromogenic medium followed by polymerase chain reaction and Sanger sequencing...
May 21, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29782406/population-pharmacokinetics-and-pharmacodynamics-of-dexmedetomidine-in-children-undergoing-ambulatory-surgery
#5
María-Gabriela Pérez-Guillé, Alejandra Toledo-López, Liliana Rivera-Espinosa, Radames Alemon-Medina, Chiharu Murata, Ismael Lares-Asseff, Juan Luis Chávez-Pacheco, Josefina Gómez-Garduño, Ana-Lilia Zamora Gutiérrez, Claudia Orozco-Galicia, Karina Ramírez-Morales, Gustavo Lugo-Goytia
BACKGROUND: Dexmedetomidine (DEX) is an α-2 adrenergic agonist with sedative and analgesic properties. Although not approved for pediatric use by the Food and Drug Administration, DEX is increasingly used in pediatric anesthesia and critical care. However, very limited information is available regarding the pharmacokinetics of DEX in children. The aim of this study was to investigate DEX pharmacokinetics and pharmacodynamics (PK-PD) in Mexican children 2-18 years of age who were undergoing outpatient surgical procedures...
May 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29781368/the-role-of-the-oncogenic-rab35-in-cancer-invasion-metastasis-and-immune-evasion-especially-in-leukemia
#6
Fabian R Villagomez, Oscar Medina-Contreras, Jorge Francisco Cerna-Cortes, Genaro Patino-Lopez
The study of cancer has allowed researchers to describe some biological characteristics that tumor cells acquire during their development, known as the "hallmarks of cancer" but more research is needed to expand our knowledge about cancer biology and to generate new strategies of treatment. The role that RabGTPases might play in some hallmarks of cancer represents interesting areas of study since these proteins are frequently altered in cancer. However, their participation is not well known. Recently, Rab35was recognized as an oncogenic RabGTPase and and because of its association with different cellular functions, distinctly important in immune cells, a possible role of Rab35 in leukemia can be suggested...
May 21, 2018: Small GTPases
https://www.readbyqxmd.com/read/29779844/towards-a-unified-perspective-of-object-shape-and-motion-processing-in-human-dorsal-cortex
#7
REVIEW
Gennady Erlikhman, Gideon P Caplovitz, Gennadiy Gurariy, Jared Medina, Jacqueline C Snow
Although object-related areas were discovered in human parietal cortex a decade ago, surprisingly little is known about the nature and purpose of these representations, and how they differ from those in the ventral processing stream. In this article, we review evidence for the unique contribution of object areas of dorsal cortex to three-dimensional (3-D) shape representation, the localization of objects in space, and in guiding reaching and grasping actions. We also highlight the role of dorsal cortex in form-motion interaction and spatiotemporal integration, possible functional relationships between 3-D shape and motion processing, and how these processes operate together in the service of supporting goal-directed actions with objects...
May 17, 2018: Consciousness and Cognition
https://www.readbyqxmd.com/read/29778854/proposed-stages-of-myocardial-phenotype-development-in-fabry-disease
#8
Sabrina Nordin, Rebecca Kozor, Katia Medina-Menacho, Amna Abdel-Gadir, Shanat Baig, Daniel M Sado, Ilaria Lobascio, Elaine Murphy, Robin H Lachmann, Atul Mehta, Nicola C Edwards, Uma Ramaswami, Richard P Steeds, Derralynn Hughes, James C Moon
OBJECTIVES: The authors sought to explore the Fabry myocardium in relation to storage, age, sex, structure, function, electrocardiogram changes, blood biomarkers, and inflammation/fibrosis. BACKGROUND: Fabry disease (FD) is a rare, x-linked lysosomal storage disorder. Mortality is mainly cardiovascular with men exhibiting cardiac symptoms earlier than women. By cardiovascular magnetic resonance, native T1 is low in FD because of sphingolipid accumulation. METHODS: A prospective, observational study of 182 FD (167 adults, 15 children; mean age 42 ± 17 years, 37% male) who underwent cardiovascular magnetic resonance including native T1, late gadolinium enhancement (LGE), and extracellular volume fraction, 12-lead electrocardiogram, and blood biomarkers (troponin and N-terminal pro-brain natriuretic peptide)...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29775773/trimeprazine-is-enantioselectively-degraded-by-an-activated-sludge-in-ready-biodegradability-test-conditions
#9
Laura Escuder-Gilabert, Yolanda Martín-Biosca, Mireia Perez-Baeza, Salvador Sagrado, María José Medina-Hernández
A great number of available pharmaceuticals are chiral compounds. Although they are usually manufactured as racemic mixtures, they can be enantioselectively biodegraded as a result of microbial processes. In this paper, a biodegradability assay in similar conditions to those recommended in OECD tests of enantiomers of trimeprazine (a phenothiazine employed as a racemate) is carried out. Experiments were performed in batch mode using a minimal salts medium inoculated with an activated sludge (collected from a Valencian Waste Water Treatment Plant, WWTP) and supplemented with the racemate...
May 9, 2018: Water Research
https://www.readbyqxmd.com/read/29773615/microbial-diversity-in-commercial-bee-pollen-from-europe-chile-and-mexico-based-on-16s-rrna-gene-amplicon-metagenome-sequencing
#10
Vicente D Moreno Andrade, Carlos Saldaña Gutiérrez, Rosa P Calvillo Medina, Andrés Cruz Hérnandez, Moisés A Vázquez Cruz, Alfonso Torres Ruíz, Sergio Romero Gómez, Miguel A Ramos López, Erika Álvarez-Hidalgo, Silvia B López-Gaytan, Natanahel Salvador Ramírez, George H Jones, Jose Luis Hernandez-Flores, Juan Campos-Guillén
Bee pollen is a highly nutritive natural foodstuff. Because of its use as a comestible, the association of bacteria with bee pollen is commercially and biologically important. We report here the bacterial diversity of seven bee pollen samples (five from Europe, one from Chile, and one from Mexico) based on 16S rRNA gene amplicon metagenome sequencing.
May 17, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29773454/role-of-the-urologist-in-the-treatment-of-renal-cancer
#11
EDITORIAL
A Juárez-Soto, V Chantada-Abad, J L Alvarez Ossorio-Fernández, J Carballido-Rodriguez, R Llarena-Ibarguren, R A Medina-López, J Moreno-Jiménez, J M Cózar Olmo
No abstract text is available yet for this article.
May 14, 2018: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29771325/native-bacteria-promote-plant-growth-under-drought-stress-condition-without-impacting-the-rhizomicrobiome
#12
Elisabeth Armada, Márcio F A Leite, Almudena Medina, Rosario Azcón, Eiko E Kuramae
Inoculation of plants with beneficial plant growth-promoting bacteria (PGPB) emerges a valuable strategy for ecosystem recovery. However, drought conditions might compromise plant-microbe interactions especially in semiarid regions. This study highlights the effect of native PGPB after one-year inoculation on autochthonous shrubs growth and rhizosphere microbial community composition and activity under drought stress conditions. We inoculated three plant species of semiarid Mediterranean zones, Thymus vulgaris, Santolina chamaecyparissus and Lavandula dentata with a Bacillus thuringiensis strain IAM 12077 and, evaluated the impact on plant biomass, plant nutrient contents, arbuscular mycorrhiza fungi (AMF) colonization, soil rhizosphere microbial activity, and both the bacterial and fungal communities...
May 16, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29771310/fingolimod-phosphate-inhibits-astrocyte-inflammatory-activity-in-mucolipidosis-iv
#13
Laura Weinstock, Amanda M Furness, Shawn Herron, Sierra S Smith, Sitara Sankar, Samantha G DeRosa, Dadi Gao, Molly E Mepyans, Anna Scotto Rosato, Diego L Medina, Ayelet Vardi, Natalia S Ferreira, Soo Min Cho, Anthony H Futerman, Susan A Slaugenhaupt, Levi B Wood, Yulia Grishchuk
Mucolipidosis IV (MLIV) is an orphan neurodevelopmental disease that causes severe neurologic dysfunction and loss of vision. Currently there is no therapy for MLIV. It is caused by loss of function of the lysosomal channel mucolipin-1, also known as TRPML1. Knockout of the Mcoln1 gene in a mouse model mirrors clinical and neuropathological signs in humans. Using this model, we previously observed robust activation of microglia and astrocytes in early symptomatic stages of disease. Here we investigate the consequence of mucolipin-1 loss on astrocyte inflammatory activation in vivo and in vitro and apply a pharmacological approach to restore Mcoln1-/- astrocyte homeostasis using a clinically approved immunomodulator, fingolimod...
May 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29768584/mortality-from-type-2-diabetes-and-implementation-of-the-prevenimss-program-a-time-series-study-in-mexico-1998-2015
#14
Oswaldo Sinoe Medina-Gómez, Ismael Seth Medina-Reyes
Type 2 diabetes is the leading cause of morbidity and mortality in the world. In Mexico it is the first cause of mortality, disability, and potential years of life lost due to premature death. The Mexican Institute of Social Security (IMSS) implemented the PREVENIMSS strategy. The aim of the current study was to estimate the program's effect on the mortality trend from type 2 diabetes, based on an interrupted time series analysis. At the beginning of the target period, the diabetes mortality rate was higher in IMSS beneficiaries than in the control population...
May 10, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29768414/adipose-derived-mesenchymal-stem-cells-admsc-for-the-treatment-of-secondary-progressive-multiple-sclerosis-a-triple-blinded-placebo-controlled-randomized-phase-i-ii-safety-and-feasibility-study
#15
Oscar Fernández, Guillermo Izquierdo, Victoria Fernández, Laura Leyva, Virginia Reyes, Miguel Guerrero, Antonio León, Carlos Arnaiz, Guillermo Navarro, Maria Dolores Páramo, Antonio De la Cuesta, Bernat Soria, Abdelkrim Hmadcha, David Pozo, Rafael Fernandez-Montesinos, Maria Leal, Itziar Ochotorena, Patricia Gálvez, Maria Angeles Geniz, Francisco Javier Barón, Rosario Mata, Cristina Medina, Carlos Caparrós-Escudero, Ana Cardesa, Natividad Cuende
BACKGROUND: Currently available treatments for secondary progressive multiple sclerosis(SPMS) have limited efficacy and/or safety concerns. Adipose-mesenchymal derived stem cells(AdMSCs) represent a promising option and can be readily obtained using minimally invasive procedures. PATIENTS AND METHODS: In this triple-blind, placebo-controlled study, cell samples were obtained from consenting patients by lipectomy and subsequently expanded. Patients were randomized to a single infusion of placebo, low-dose(1x106cells/kg) or high-dose(4x106cells/kg) autologous AdMSC product and followed for 12 months...
2018: PloS One
https://www.readbyqxmd.com/read/29768277/the-brief-sexual-symptom-checklist-as-a-screening-tool-for-sex-related-problems-in-the-primary-care-setting-focus-on-erectile-dysfunction
#16
Javier Romero Otero, Borja García Gómez, José Medina Polo, Esther García Rojo, Eduardo García Cruz, Francois Peinado, Raquel Sopeña Sutil, Giorgio Bozzini, Alfredo Rodríguez Antolín
PURPOSE: To assess the performance of the Brief Sexual Symptom Checklist for men (BSSC-M) questionnaire in General Practitioner's (GP) consults in Spain. METHODS: Multicenter, cross-sectional study conducted in Spain among men ≥50 years, visiting a GP for any reason, and being able to answer self-administered questionnaires. Patients receiving medicines for erectile dysfunction (ED) and those with poor functional status were excluded. Sexual satisfaction was assessed by the BSSC-M, ED by the Sexual Health Inventory for Men (SHIM), and quality of life (QoL) using a 5-point Likert scale...
May 16, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29767455/ureterocalicostomy-with-lower-pole-nephrectomy-in-a-renal-transplant-a-case-report
#17
Rafael Haddad Astolfi, Guilherme Alonso Daud Patavino, Claudia Felipe Rosso, Helio Tedesco Silva Junior, Jose Osmar Medina Pestana, Alex Elton Meller, Wilson Aguiar
As the number of kidney transplants continues to rise, so does the number and complexities of surgical-related complications, which may be associated with increased morbidity and potentially graft loss. Ureteral stenosis, the most prevalent urological complication, may require diverse techniques for surgical correction depending on several recipient and graft abnormalities. Here we report the surgical and clinical outcomes of a 62-year-old man with a postransplant pyeloureterostomy stricture successfully treated with ureterocalycostomy after a lower pole nephrectomy...
May 16, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29764664/agriculture-sows-pests-how-crop-domestication-host-shifts-and-agricultural-intensification-can-create-insect-pests-from-herbivores
#18
REVIEW
Julio S Bernal, Raul F Medina
We argue that agriculture as practiced creates pests. We use three examples (Corn leafhopper, Dalbulus maidis; Western corn rootworm, Diabrotica virgifera virgifera; Cotton fleahopper, Pseudatomoscelis seriatus) to illustrate: firstly, how since its origins, agriculture has proven conducive to transforming selected herbivores into pests, particularly through crop domestication and spread, and agricultural intensification, and; secondly, that the herbivores that became pests were among those hosted by crop wild relatives or associates, and were pre-adapted either as whole species or component subpopulations...
April 2018: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/29764315/effects-of-egg-consumption-and-choline-supplementation-on-plasma-choline-and-trimethylamine-n-oxide-in-a-young-population
#19
Bruno S Lemos, Isabel Medina-Vera, Olga V Malysheva, Marie A Caudill, Maria Luz Fernandez
BACKGROUND: Plasma trimethylamine-N-oxide (TMAO) concentrations have been associated with cardiovascular disease risk. Eggs are a rich source of choline, which is a precursor of TMAO. OBJECTIVE: The effects of egg intake versus daily choline supplementation were evaluated on plasma choline and TMAO in a young, healthy population. METHODS: Thirty participants (14 males, 16 females; 25.6 ± 2.3 years; body mass index = 24.3 ± 2.9 kg/m2 ) were enrolled in this 13-week crossover intervention...
May 15, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29763702/immunostimulant-effects-and-potential-application-of-%C3%AE-glucans-derived-from-marine-yeast-debaryomyces-hansenii-in-goat-peripheral-blood-leucocytes
#20
Noé Medina-Córdova, Martha Reyes-Becerril, Felipe Ascencio, Thelma Castellanos, Angel I Campa-Córdova, Carlos Angulo
Debaryomyces hansenii has been described to be effective probiotic and immunostimulatory marine yeast in fish. Nonetheless, to the best of our knowledge, it has been not assayed in ruminants. This study attempts to describe the immunostimulatory effects of its β-glucan content through in vitro assays using goat peripheral blood leukocytes at 24 h of stimulation. The structural characterization of yeast glucans by proton nuclear magnetic resonance indicated structures containing (1-6)-branched (1-3)-β-D-glucan...
May 12, 2018: International Journal of Biological Macromolecules
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