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https://www.readbyqxmd.com/read/28641953/is-it-necessary-a-scale-to-evaluate-the-posttraumatic-psychiatric-sequelae
#1
Julio A Guija, Lucas Giner, Antonio Medina, José Giner
No abstract text is available yet for this article.
June 19, 2017: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/28641575/phylogenetic-and-paleobotanical-evidence-for-late-miocene-diversification-of-the-tertiary-subtropical-lineage-of-ivies-hedera-l-araliaceae
#2
V Valcárcel, B Guzmán, N G Medina, P Vargas, J Wen
BACKGROUND: Hedera (ivies) is one of the few temperate genera of the primarily tropical Asian Palmate group of the Araliaceae, which extends its range out of Asia to Europe and the Mediterranean basin. Phylogenetic and phylogeographic results suggested Asia as the center of origin and the western Mediterranean region as one of the secondary centers of diversification. The bird-dispersed fleshy fruits of ivies suggest frequent dispersal over long distances (e.g. Macaronesian archipelagos), although reducing the impact of geographic barriers to gene flow in mainland species...
June 22, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28641574/intermittent-low-platelet-counts-hampering-diagnosis-of-x-linked-thrombocytopenia-in-children-report-of-two-unrelated-cases-and-a-novel-mutation-in-the-gene-coding-for-the-wiskott-aldrich-syndrome-protein
#3
Samuel Souza Medina, Lúcia Helena Siqueira, Marina Pereira Colella, Gabriela Goes Yamaguti-Hayakawa, Bruno Kosa Lino Duarte, Maria Marluce Dos Santos Vilela, Margareth Castro Ozelo
BACKGROUND: Thrombocytopenia can occur in different circumstances during childhood and although immune thrombocytopenia is its most frequent cause, it is important to consider other conditions, especially when there is a persistent or recurrent low platelet count. We report two cases of intermittent thrombocytopenia, previously misdiagnosed as immune thrombocytopenia. CASES PRESENTATION: Both cases described were boys who presented with an intermittent pattern of thrombocytopenia, with a persistently low mean platelet volume...
June 22, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28641452/anti-inflammatory-and-antiproliferative-activities-of-ixora-brevifolia-benth-rubiaceae
#4
Rebeca P Medina, Vagner M de Moura, Cleuza C da Silva, Cecília M A de Oliveira, Lucilia Kato, Armando M Pomini, João E de Carvalho, Ana Lúcia T G Ruiz, Ciomar A Bersani-Amado, Silvana M O Santin
The crude extract and fractions from the branches of Ixora brevifolia, a tree found in the Brazilian Cerrado, were tested for anti-inflammatory and in vitro antiproliferative effects. The crude extract and n-hexane fraction exhibited significant inhibition of ear oedema in mice, while n-hexane-precipitated and chloroform fractions strongly inhibited the myeloperoxidase activity in ear tissue. The n-hexane and n-hexane-precipitated fractions showed strong growth inhibition for glioma cell line and the hydromethanolic fraction inhibited the growth of leukaemia cell line...
June 23, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28641277/association-of-the-cfh-y402h-polymorphism-with-the-1-year-response-of-exudative-amd-to-intravitreal-anti-vegf-treatment-in-the-brazilian-population
#5
Flavio Mac Cord Medina, Augusto Alves Lopes da Motta, Walter Yukihiko Takahashi, Pedro Carlos Carricondo, Mario Martins Dos Santos Motta, Monica B Melo, Jose Paulo C Vasconcellos
AIM: Evidence of the relationship between the polymorphism of the complement factor H (CFH) gene at position 402 (Y402H) and the response to the treatment of wet AMD is controversial. The aim of this study was to compare the functional and morphological 1-year evolution of patients with exudative AMD treated with antivascular endothelial growth factor (VEGF) drugs with the CFH Y402H polymorphism in the Brazilian population. METHODS: Forty-six patients treated for wet AMD with bevacizumab or ranibizumab in a pro re nata regimen were included...
June 23, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28637235/monotherapy-with-either-dolutegravir-or-raltegravir-fails-to-durably-suppress-hiv-viraemia-in-humanized-mice
#6
Alonso Heredia, Said Hassounah, Sandra Medina-Moreno, Juan C Zapata, Nhut M Le, Yingshan Han, James S Foulke, Charles Davis, Joseph Bryant, Robert R Redfield, Mark A Wainberg
Objectives: To compare the effectiveness of HIV integrase inhibitor monotherapy between raltegravir and dolutegravir as an approach to simplify therapy. Methods: We evaluated and compared the efficacy of 20 week monotherapy with dolutegravir or raltegravir in humanized mice (HSC-NSG) infected with HIV BaL . Plasma HIV RNA was measured by quantitative RT-PCR (limit of detection of 150 copies/45 μL of plasma) and drug levels by LC-MS/MS. Escape viruses were genotyped and analysed for replication capacity and drug susceptibility in tissue culture...
June 13, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28632677/preexisting-ocular-motor-palsy-and-central-neuroaxial-block-a-reply-to-dr-nair
#7
Monica Del-Rio-Vellosillo, Jose Javier Garcia-Medina, Maria Dolores Pinazo-Duran, Antonio Abengochea-Cotaina, Manuel Barbera-Alacreu
No abstract text is available yet for this article.
July 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28631889/microrna-containing-extracellular-vesicles-released-from-endothelial-colony-forming-cells-modulate-angiogenesis-during-ischaemic-retinopathy
#8
Margaret Dellett, Eoin D Brown, Jasenka Guduric-Fuchs, Anna O'Connor, Alan W Stitt, Reinhold J Medina, David A Simpson
Endothelial colony-forming cells (ECFCs) are a defined subtype of endothelial progenitors that modulate vascular repair and promote perfusion in ischaemic tissues. Their paracrine activity on resident vasculature is ill-defined, but mediated, at least in part, by the transfer of extracellular vesicles (EVs). To evaluate the potential of isolated EVs to provide an alternative to cell-based therapies, we first performed a physical and molecular characterization of those released by ECFCs. Their effects upon endothelial cells in vitro and angiogenesis in vivo in a model of proliferative retinopathy were assessed...
June 20, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28631514/pharmacokinetics-and-dosing-requirements-of-digoxin-in-pregnant-women-treated-for-fetal-supraventricular-tachycardia
#9
Ana Martin-Suarez, Jose German Sanchez-Hernandez, Fabiola Medina-Barajas, Jonas Samuel Perez Blanco, Jose M Lanao, Luisa Garcia-Cuenllas Alvarez, M Victoria Calvo
BACKGROUND: The objective of this study was to characterize the pharmacokinetics (PK) of digoxin in pregnant women and its potential implications for drug dosing. METHODS: Serum digoxin concentrations (SDCs) obtained in pregnant women treated for fetal supraventricular tachycardia (SVT) was retrospectively collected. PK analysis was comparatively performed using a two-stage approach (PKS™) and a Population PK approach (NONMEM™). As clinical outcome the fetal heart rate was recorded...
June 20, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28630816/the-effects-of-an-auditory-matching-ipad-app-on-three-preschoolers-echoic-and-listener-responses
#10
Lin Du, Jeanne Speckman, Megan Medina, Michelle Cole-Hatchard
We investigated the effects of an auditory match-to-sample protocol on three preschoolers' accurate echoics to 100 English words and advanced listener responses. The protocol was presented by using an iPad app Sounds the same: an app to target listening and speaking clearly. We used a combination of a multiple probe design (for echoic responses) and a delayed multiple probe design (for advanced listener literacy responses) with a time-lagged baseline across participants to test the effectiveness of the protocol...
June 2017: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/28630519/strategies-for-improving-learner-metacognition-in-health-professional-education
#11
REVIEW
Melissa S Medina, Ashley N Castleberry, Adam M Persky
Metacognition is an essential skill in critical thinking and self-regulated, lifelong learning. It is important for learners to have skills in metacognition because they are used to monitor and regulate reasoning, comprehension, and problem-solving, which are fundamental components/outcomes of pharmacy curricula. Instructors can help learners develop metacognitive skills within the classroom and experiential setting by carefully designing learning activities within courses and the curriculum. These skills are developed through intentional questioning, modeling techniques, and reflection...
May 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28629427/targeting-vegfr-3-2-signaling-pathways-with-ad0157-a-potential-strategy-against-tumor-associated-lymphangiogenesis-and-lymphatic-metastases
#12
Melissa García-Caballero, Jenny Paupert, Silvia Blacher, Maureen Van de Velde, Ana Rodríguez Quesada, Miguel Angel Medina, Agnès Noël
BACKGROUND: Lymphatic metastasis is one of the leading causes of death in patients with different types of cancer and is the main prognostic factor for the disease survival. The formation of new lymphatic vessels (lymphangiogenesis) in primary tumors facilitates tumor cell dissemination to regional lymph nodes and correlates with distant metastases. Lymphangiogenesis has thus emerged as a suitable therapeutic target to block metastases, but no anti-lymphangiogenic compounds have been approved for clinical use to date...
June 19, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28628443/novel-avulaviruses-in-penguins-antarctica
#13
Víctor Neira, Rodrigo Tapia, Claudio Verdugo, Gonzalo Barriga, Sunil Mor, Terry Fei Fan Ng, Victoria García, José Del Río, Pedro Rodrigues, Cristóbal Briceño, Rafael A Medina, Daniel González-Acuña
We identified 3 novel and distinct avulaviruses from Gentoo penguins sampled in Antarctica. We isolated these viruses and sequenced their complete genomes; serologic assays demonstrated that the viruses do not have cross-reactivity between them. Our findings suggest that these 3 new viruses represent members of 3 novel avulavirus species.
July 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28627236/estrogen-receptor-1-esr1-gene-polymorphisms-and-obesity-phenotypes-in-a-population-of-young-adults
#14
María Correa-Rodríguez, Jacqueline Schmidt-RioValle, Emilio González-Jiménez, Blanca Rueda-Medina
Obesity is considered an increasingly serious health problem determined by multiple genetic and environmental factors. Estrogens have been found to play a major role in body weight and adiposity regulation through estrogen receptor 1 ( ESR1). The aim of this study was to determine whether genotype and haplotype frequencies of ESR1 polymorphisms are associated with body composition measures in a population of 572 young adults. A lack of significant association between genotypes of ESR1 gene polymorphisms and obesity phenotypes was seen after adjustment for confounding factors...
June 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/28627197/dietary-antioxidant-quality-score-daqs-is-associated-with-bone-mass-assessed-by-calcaneal-quantitative-ultrasound-in-young-women
#15
María Correa Rodríguez, Jacqueline Schmidt-RioValle, Blanca Rueda-Medina
INTRODUCTION: Evidence suggests that intake of antioxidants could positively influence bone mass by preventing bone metabolism against oxidative stress. OBJECTIVE: We aimed to investigate the possible influence of single antioxidant intakes and dietary antioxidant quality score (DAQs) on calcaneal quantitative ultrasound (QUS) in a population of young adults. METHODS: A total of 605 young Spanish adults participated in this study (median age 20...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28627189/-nitrogenous-content-in-parenteral-nutrition-a-four-year-experience-in-a-general-hospital-critically-ill-patient-specificity
#16
Juan Luis Villalobos-Gámez, Carlos Lara-Ramos, Yolanda Domínguez-Rivas, Antonio Vallejo-Báez, Francisco Cota-Delgado, Efrén Márquez-Fernández, José Manuel García-Almeida, José Antonio López-Medina, Rosalía Rioja-Vázquez, Albert Santacreu-Regí, Francisca Rius-Díaz, Alfredo Mínguez-Mañanes
INTRODUCTION: There have been several studies focusing on caloric intake during the last years, while protein content relevance has been underestimated. Some recent evidence has shown that protein deficiency has also an impact on patient outcomes. We have studied the nitrogen (N) content in parenteral nutrition (PN) bags administered to adult patients in a Spanish tertiary level hospital for four years. MATERIAL AND METHODS: Patients who received parenteral nutrition in the general ward and Intensive Care Unit (ICU) were recorded...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28627185/adherencia-y-tolerancia-como-claves-en-la-detenci%C3%A3-n-de-la-p%C3%A3-rdida-de-peso-en-pacientes-oncol%C3%A3-gicos-sometidos-a-radioterapia-mediante-una-estrategia-de-suplementaci%C3%A3-n-precoz-con-una-f%C3%A3-rmula-enteral-hipercal%C3%A3-rica-e-hiperproteica-espec%C3%A3-fica
#17
Jose M García Almeida, Yolanda Lupiáñez Pérez, Mercedes Blanco Naveira, Josefina Ruiz Nava, José Antonio Medina, Isabel Cornejo Pareja, Ana Gómez Pérez, María Molina Vega, José A López-Medina, Francisco Tinahones Madueño
Introducción: en pacientes con riesgo nutricional, la Sociedad Europea de Clínica y Metabolismo (ESPEN) y Parenteral recomienda suplementos nutricionales durante el tratamiento oncológico para prevenir la pérdida de peso involuntaria.Objetivos: nuestro objetivo es conocer el cumplimiento, la aceptabilidad y la tolerancia de un suplemento hiperproteico, hipercalórico, rico en omega 3 en pacientes oncológicos.Métodos: estudio unicéntrico, observacional y prospectivo en pacientes oncológicos con un suplemento nutricional hiperproteico, hipercalórico, rico en omega 3 y de bajo volumen...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28625840/survival-of-litopenaeus-vannemei-shrimp-fed-on-diets-supplemented-with-dunaliella-sp-is-improved-after-challenges-by-vibrio-parahaemolyticus
#18
Diana Medina Félix, José Antonio López Elías, Ángel Isidro Campa Córdova, Luis Rafael Martínez Córdova, Antonio Luna González, Edilmar Cortez Jacinto, Nolberta Huerta Aldaz, Fernando Cano Mendoza, María Guadalupe Burboa Zazueta
Survival of Litopenaeus vannamei was evaluated during a Vibrio parahaemolyticus infection. This bacteria has been causing significant economic losses in the shrimp industry due to the appearance of early mortality syndrome (EMS), also known as acute hepatopancreatic necrosis disease (AHPND). Control of bacteria in ponds is difficult to achieve with antibiotics due to environmental infections and antibiotic resistance. New methods have been proposed to control and prevent the impact of bacterial infections. The physiological response indicated by plasma biochemical parameters in shrimp can determine their health and stress status...
June 15, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28625214/post-traumatic-stress-disorder-associated-with-sexual-assault-among-women-in-the-who-world-mental-health-surveys
#19
K M Scott, K C Koenen, A King, M V Petukhova, J Alonso, E J Bromet, R Bruffaerts, B Bunting, P de Jonge, J M Haro, E G Karam, S Lee, M E Medina-Mora, F Navarro-Mateu, N A Sampson, V Shahly, D J Stein, Y Torres, A M Zaslavsky, R C Kessler
BACKGROUND: Sexual assault is a global concern with post-traumatic stress disorder (PTSD), one of the common sequelae. Early intervention can help prevent PTSD, making identification of those at high risk for the disorder a priority. Lack of representative sampling of both sexual assault survivors and sexual assaults in prior studies might have reduced the ability to develop accurate prediction models for early identification of high-risk sexual assault survivors. METHODS: Data come from 12 face-to-face, cross-sectional surveys of community-dwelling adults conducted in 11 countries...
June 19, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28624633/from-flamingo-dance-to-desirable-drug-discovery-a-nature-inspired-approach
#20
REVIEW
Aminael Sánchez-Rodríguez, Yunierkis Pérez-Castillo, Stephan C Schürer, Orazio Nicolotti, Giuseppe Felice Mangiatordi, Fernanda Borges, M Natalia D S Cordeiro, Eduardo Tejera, José L Medina-Franco, Maykel Cruz-Monteagudo
The therapeutic effects of drugs are well known to result from their interaction with multiple intracellular targets. Accordingly, the pharma industry is currently moving from a reductionist approach based on a 'one-target fixation' to a holistic multitarget approach. However, many drug discovery practices are still procedural abstractions resulting from the attempt to understand and address the action of biologically active compounds while preventing adverse effects. Here, we discuss how drug discovery can benefit from the principles of evolutionary biology and report two real-life case studies...
June 15, 2017: Drug Discovery Today
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