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JOURNAL ARTICLE
Esther Prados De la Torre, Josefina Serrano, David Martínez-Cuadrón, Laura Torres, Claudia Sargas, Rosa Ayala, Cristina Bilbao-Sieyro, María Carmen Chillón, María José Larráyoz, Elena Soria, Clara Aparicio-Pérez, Juan M Bergua, Teresa Bernal, Cristina Gil, Mar Tormo, Lorenzo Algarra, Juan M Alonso-Domínguez, Eduardo Rodriguez-Arbolí, Pilar Martínez-Sanchez, Ana Oliva, Ana M Colorado-Araujo, Carlos Rodríguez-Medina, Susana Vives, Lourdes Hermosín, Joaquín Martínez-López, Ramón García-Sanz, José A Pérez-Simón, María José Calasanz, María Teresa Gómez-Casares, Eva Barragán, Joaquín Sánchez-García J, Pau Montesinos
Not available.
April 18, 2024: Haematologica
#2
JOURNAL ARTICLE
J Sebastian Garcia-Medina, Karolina Sienkiewicz, S Anand Narayanan, Eliah G Overbey, Kirill Grigorev, Krista A Ryon, Marissa Burke, Jacqueline Proszynski, Braden Tierney, Caleb M Schmidt, Nuria Mencia-Trinchant, Remi Klotz, Veronica Ortiz, Jonathan Foox, Christopher Chin, Deena Najjar, Irina Matei, Irenaeus Chan, Carlos Cruchaga, Ashley Kleinman, JangKeun Kim, Alexander Lucaci, Conor Loy, Omary Mzava, Iwijn De Vlaminck, Anvita Singaraju, Lynn E Taylor, Julian C Schmidt, Michael A Schmidt, Kelly Blease, Juan Moreno, Andrew Boddicker, Junhua Zhao, Bryan Lajoie, Andrew Altomare, Semyon Kruglyak, Shawn Levy, Min Yu, Duane C Hassane, Susan M Bailey, Kelly Bolton, Jaime Mateus, Christopher E Mason
BACKGROUND: The Inspiration4 (I4) mission, the first all-civilian orbital flight mission, investigated the physiological effects of short-duration spaceflight through a multi-omic approach. Despite advances, there remains much to learn about human adaptation to spaceflight's unique challenges, including microgravity, immune system perturbations, and radiation exposure. METHODS: To provide a detailed genetics analysis of the mission, we collected dried blood spots pre-, during, and post-flight for DNA extraction...
March 2024: Precision Clinical Medicine
#3
JOURNAL ARTICLE
Juan Carlos Núñez-Enríquez, Rubí Romo-Rodríguez, Pedro Gaspar-Mendoza, Gabriela Zamora-Herrera, Lizeth Torres-Pineda, Jiovanni Amador-Cardoso, Jebea A López-Blanco, Laura Alfaro-Hernández, Lucero López-García, Arely Rosas-Cruz, Dulce Rosario Alberto-Aguilar, César Omar Trejo-Pichardo, Dalia Ramírez-Ramírez, Astin Cruz-Maza, Janet Flores-Lujano, Nuria Luna-Silva, Angélica Martínez-Martell, Karina Martínez-Jose, Anabel Ramírez-Ramírez, Juan Carlos Solis-Poblano, Patricia Zagoya-Martínez, Vanessa Terán-Cerqueda, Andrea Huerta-Moreno, Álvaro Montiel-Jarquín, Miguel Garrido-Hernández, Raquel Hernández-Ramos, Daniela Olvera-Caraza, Cynthia Shanat Cruz-Medina, Enoch Alvarez-Rodríguez, Lénica Anahí Chávez-Aguilar, Wilfrido Herrera-Olivares, Brianda García-Hidalgo, Lena Sarahí Cano-Cuapio, Claudia Guevara-Espejel, Gerardo Juárez-Avendaño, Juan Carlos Balandrán, Ma Del Rocío Baños-Lara, Mariana Cárdenas-González, Elena R Álvarez-Buylla, Sonia Mayra Pérez-Tapia, Diana Casique-Aguirre, Rosana Pelayo
The main objective of the National Project for Research and Incidence of Childhood Leukemias is to reduce early mortality rates for these neoplasms in the vulnerable regions of Mexico. This project was conducted in the states of Oaxaca, Puebla, and Tlaxcala. A key strategy of the project is the implementation of an effective roadmap to ensure that leukemia patients are the target of maximum benefit of interdisciplinary collaboration between researchers, clinicians, surveyors, and laboratories. This strategy guarantees the comprehensive management of diagnosis and follow-up samples of pediatric patients with leukemia, centralizing, managing, and analyzing the information collected...
2024: Frontiers in Oncology
#4
JOURNAL ARTICLE
Pedro Junqueira Fleury Silva, Caroline Martins Silva, Brunno Machado de Campos, Paula de Melo Campos, Samuel de Souza Medina, Andreza Lamonica, José Vitor Coimbra Trindade, Fernando Cendes, Fernando Ferreira Costa, Sara Teresinha Olalla Saad, Bruno Deltreggia Benites
Sickle cell disease (SCD) patients are at higher risk of developing silent cerebral infarcts and overt stroke, which may reflect cognitive impairment, functional limitations, and worse quality of life. The cognitive function of Brazilian adult SCD patients ( n = 124; 19-70 years; 56 men; 79 SS, 28 SC, 10 S/β0 , 7 S/β+ ) was screened through Montreal Cognitive Assessment (MoCA) and correlated the results with possible predictive factors for test performance, including sociocultural, clinical, laboratory data and brain imaging...
April 2024: EJHaem
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JOURNAL ARTICLE
J M Pinazo-Bandera, H Niu, Alvarez-Alvarez, Medina-Caliz, E Del Campo-Herrera, A Ortega-Alonso, M Robles-Díaz, N Hernández, R Paraná, Nunes, M Girala, F Bessone, M I Lucena, R J Andrade, M García Cortés
INTRODUCTION: Data on positive rechallenge in idiosyncratic drug-induced liver injury (DILI) are scarce. We aim to analyse the clinical presentation, outcome and drugs associated with positive rechallenge in two DILI registries. METHODS: Cases from the Spanish and Latin American DILI registries were included. Demographics, clinical characteristics and outcome of cases with positive rechallenge according to CIOMS/RUCAM and current definitions were analysed. RESULTS: Of 1,418 patients with idiosyncratic DILI, 58 cases had positive rechallenge (4...
April 15, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
#6
JOURNAL ARTICLE
Mónica Crespo Balbuena, Ángela Salmerón Ruiz, Antonio Medina Benítez, María Gómez Huertas, Mario Rivera Izquierdo, Antonio Jesús Láinez Ramos-Bossini
No abstract text is available yet for this article.
April 15, 2024: Journal of Gastrointestinal Surgery
#7
REVIEW
Marcel Pérez-Morales, Paola C Bello-Medina, Diego A González-Franco, Sofía Díaz-Cintra, Jaime García-Mena, Gustavo Pacheco-López
BACKGROUND: Over the last century, animal models have been employed to study the gut-brain axis and its relationship with physiological processes, including those necessary for survival, such as food intake regulation and thermoregulation; those involved in diseases, ranging from inflammation to obesity; and those concerned to the development of neurodegenerative diseases and neuropsychiatric disorders, such as Alzheimer's disease and autism spectrum disorder, respectively. SUMMARY: The gut microbiota has been recognized in the last decade as an essential functional component of this axis...
April 17, 2024: Neuroimmunomodulation
#8
JOURNAL ARTICLE
Elsa D Ibáñez-Prada, Ingrid G Bustos, Enrique Gamboa-Silva, Diego F Josa, Lina Mendez, Yuli V Fuentes, Cristian C Serrano-Mayorga, Oscar Baron, Alejandra Ruiz-Cuartas, Edwin Silva, Louise M Judd, Taylor Harshegyi, Hector F Africano, Juan Urrego-Reyes, Claudia C Beltran, Sebastian Medina, Rafael Leal, Andrew J Stewardson, Kelly L Wyres, Jane Hawkey, Luis Felipe Reyes
In this study, the genetic differences and clinical impact of the carbapenemase-encoding genes among the community and healthcare-acquired infections were assessed. This retrospective, multicenter cohort study was conducted in Colombia and included patients infected with carbapenem-resistant Gram-negative rods between 2017 and 2021. Carbapenem resistance was identified by Vitek, and carbapenemase-encoding genes were identified by whole-genome sequencing (WGS) to classify the alleles and sequence types (STs)...
April 17, 2024: Microbiology Spectrum
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JOURNAL ARTICLE
Gloria Aguilar, Gladys Lopez, Omar Sued, Narda Medina, Diego H Caceres, Jose Pereira, Alexander Jordan, Virgilio Lezcano, Cristina Vicenti, Gustavo Benitez, Tania Samudio, Freddy Perez
BACKGROUND: Opportunistic infections (OIs) are common causes of mortality among people living with HIV (PLHIV). We determined prevalence and 30-day mortality due to histoplasmosis, cryptococcosis, and TB in PLHIV with advanced HIV disease (AHD). METHODS: PLHIV 18 years and older, with a CD4 + T-cell count of less than 350 cells/mm3 newly diagnosed with HIV infection or re-engaged in care after being without ART for more than 90 days (Group A). The second group included symptomatic PLHIV regardless of ART status or CD4 + T-cell count (Group B); all followed for 30 days...
April 16, 2024: BMC Infectious Diseases
#10
JOURNAL ARTICLE
Roberto Bernabéu-Mora, Silvana Loana Oliveira-Sousa, Francesc Medina-Mirapeix, Mariano Gacto-Sánchez
BACKGROUND: The objective of this study was to determine whether the concomitant presence of poor health status (COPD Assessment Test, CAT ≥ 10 points) and low exercise tolerance (6-Minute Walking Test, 6MWT < 350 m) is associated with worse clinical characteristics in patients with COPD. In addition, we aimed to develop a readily applicable diagnostic model to discriminate COPD patients with these conditions. METHODS: A cross-sectional multicenter study involving 208 stable COPD patients (FEV1/FVC < 0...
April 15, 2024: European Journal of Internal Medicine
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JOURNAL ARTICLE
Carlos Carazo Casas, Marimar Medina Gonzalez
New England Journal of Medicine, Volume 390, Issue 15, April 2024.
April 13, 2024: New England Journal of Medicine
#12
JOURNAL ARTICLE
Juli Celina Medina Gontier, Lea Wienandts, Susann Endermann
BACKGROUND Unintentional medication-blister ingestion is rare but frequently leads to intestinal perforation. The diagnosis of intestinal perforation following blister ingestion is often delayed because of an unreliable history and nonspecific clinical presentation. The purpose of this case report is to raise awareness about a rare but difficult diagnosis and its importance in avoiding potentially fatal events. CASE REPORT Herein, we describe successful cases of surgical and endoscopic removal after blister ingestion...
April 16, 2024: American Journal of Case Reports
#13
Ryan Gamba, Negin Toosi, Lana Wood, Alexandra Correia, Nomar Medina, Maria Pritchard, Jhamon Venerable, Mikayla Lee, Joshua Kier Adrian Santillan
No abstract text is available yet for this article.
April 15, 2024: BMC Public Health
#14
REVIEW
Cristina Díaz Del Arco, M Jesús Fernández Aceñero, Luis Ortega Medina
After the study of circulating tumor cells in blood through liquid biopsy (LB), this technique has evolved to encompass the analysis of multiple materials originating from the tumor, such as nucleic acids, extracellular vesicles, tumor-educated platelets, and other metabolites. Additionally, research has extended to include the examination of samples other than blood or plasma, such as saliva, gastric juice, urine, or stool. LB techniques are diverse, intricate, and variable. They must be highly sensitive, and pre-analytical, patient, and tumor-related factors significantly influence the detection threshold, diagnostic method selection, and potential results...
March 28, 2024: World Journal of Gastroenterology: WJG
#15
JOURNAL ARTICLE
Lorenzo Gervaso, Alice Laffi, Aurora Gaeta, Sara Gandini, Laura Boldrini, Monica Isabel Meneses-Medina, Manila Rubino, Lavinia Benini, Michele Borghesani, Laura Algeri, Giuseppe Curigliano, Francesca Spada, Chiara Alessandra Cella, Nicola Fazio
No abstract text is available yet for this article.
March 2024: Research and Practice in Thrombosis and Haemostasis
#16
REVIEW
Xiaofei Zhou, Iliana E Medina-Ramirez, Gaoxing Su, Yin Liu, Bing Yan
Autophagy, vital for removing cellular waste, is triggered differently by small molecules and nanoparticles. Small molecules, like rapamycin, non-selectively activate autophagy by inhibiting the mTOR pathway, which is essential for cell regulation. This can clear damaged components but may cause cytotoxicity with prolonged use. Nanoparticles, however, induce autophagy, often causing oxidative stress, through broader cellular interactions and can lead to a targeted form known as "xenophagy." Their impact varies with their properties but can be harnessed therapeutically...
April 15, 2024: Small
#17
JOURNAL ARTICLE
A Ortiz de Mendivil, P Martín-Medina, L García-Cañamaque, B Jiménez-Munarriz, R Ciérvide, J Diamantopoulos
MRI is the cornerstone in the evaluation of brain metastases. The clinical challenges lie in discriminating metastases from mimickers such as infections or primary tumors and in evaluating the response to treatment. The latter sometimes leads to growth, which must be framed as pseudo-progression or radionecrosis, both inflammatory phenomena attributable to treatment, or be considered as recurrence. To meet these needs, imaging techniques are the subject of constant research. However, an exponential growth after radiotherapy must be interpreted with caution, even in the presence of results suspicious of tumor progression by advanced techniques, because it may be due to inflammatory changes...
2024: Radiología
#18
JOURNAL ARTICLE
María José Fernández-Fernández, Alejandro Jesús de Medina-Moragas
PURPOSE: The effects of episiotomy and second-degree tears on postpartum sexual function are key areas of enquiry in women's health research. Episiotomy and second-degree tears are common procedures and injuries that occur during childbirth. Understanding their impact on post-childbirth sexuality is crucial to women's overall well-being. This study aimed to examine the relationship between episiotomy, second-degree tears, and post childbirth sexuality. METHODS: A cross-sectional design was employed, including 83 women who gave birth to Cáceres in 2017...
April 13, 2024: Archives of Gynecology and Obstetrics
#19
JOURNAL ARTICLE
Seidy Y Aguilar-Martínez, Gabriela E Campos-Viguri, Selma E Medina-García, Ricardo J García-Flores, Jessica Deas, Claudia Gómez-Cerón, Abraham Pedroza-Torres, Elizabeth Bautista-Rodríguez, Gloria Fernández-Tilapa, Mauricio Rodríguez-Dorantes, Carlos Pérez-Plasencia, Oscar Peralta-Zaragoza
Expression of miR-21 has been found to be altered in almost all types of cancers, and it has been classified as an oncogenic microRNA. In addition, the expression of tumor suppressor gene RECK is associated with miR-21 overexpression in high-grade cervical lesions. In the present study, we analyze the role of miR-21 in RECK gene regulation in cervical cancer cells. To identify the downstream cellular target genes of upstream miR-21, we silenced endogenous miR-21 expression using siRNAs. We analyzed the expression of miR-21 and RECK, as well as functional effects on cell proliferation and migration...
April 6, 2024: International Journal of Molecular Sciences
#20
REVIEW
María Dolores Suárez-Medina, María Isabel Sáez-Casado, Tomás Martínez-Moya, Miguel Ángel Rincón-Cervera
Marine foods are highly perishable products due to their high content of polyunsaturated fatty acids, which can be readily oxidized to form peroxides and secondary oxidation products, thus conferring such foods undesirable organoleptic characteristics and generating harmful compounds that are detrimental to the health of consumers. The use of preservation methods that minimize lipid oxidation is required in the fishing and aquaculture industries. Low temperature storage (chilling or freezing) is one of the most commonly used preservation methods for fish and seafood, although it has been shown that the oxidation of the lipid fraction of such products is partially but not completely inhibited at low temperatures...
April 3, 2024: Foods (Basel, Switzerland)
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