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https://www.readbyqxmd.com/read/27921331/living-in-limbo-latinas-assessment-of-lower-rio-grande-valley-colonias-communities
#1
DeAnne K Hilfinger Messias, Patricia A Sharpe, Lourdes Del Castillo-González, Laura Treviño, Deborah Parra-Medina
Community asset mapping (CAM) is the collective process of identifying local assets and strategizing processes to address public health issues and concerns and improve quality of life. Prior to implementing a community-based physical activity intervention with Latinas in the Texas Lower Rio Grande Valley, promotoras [community health workers] conducted 16 interactive sessions in 8 colonias. The analysis of the transcribed CAM recordings and on-site observational data resulted in the construction of Living in Limbo as the thematic representation of these Latinas' social isolation and marginalization associated with pervasive poverty, undocumented immigration status or lack of citizenship, their fears emanating from threats to physical and emotional safety, and the barriers created by lack of availability and access to resources...
December 5, 2016: Public Health Nursing
https://www.readbyqxmd.com/read/27920787/interactive-effects-of-elevated-co2-and-water-stress-on-physiological-traits-and-gene-expression-during-vegetative-growth-in-four-durum-wheat-genotypes
#2
Susan Medina, Rubén Vicente, Amaya Amador, José Luis Araus
The interaction of elevated [CO2] and water stress will have an effect on the adaptation of durum wheat to future climate scenarios. For the Mediterranean basin these scenarios include the rising occurrence of water stress during the first part of the crop cycle. In this study, we evaluated the interactive effects of elevated [CO2] and moderate to severe water stress during the first part of the growth cycle on physiological traits and gene expression in four modern durum wheat genotypes. Physiological data showed that elevated [CO2] promoted plant growth but reduced N content...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27919790/preservation-of-malassezia-pachydermatis-using-skimmed-milk-as-cryoprotective-agent
#3
F A Silva Sergent, B Acosta-Hernández, J R Jaber, I Rosario Medina, F Real Valcárcel, D Padilla Castillo, S Déniz Suárez
This study evaluated the effect of skimmed milk as a cryoprotectant for the maintenance and long-term preservation of 70 Malassezia pachydermatis strains. An initial suspension of each strain was prepared in sterile distilled water with skimmed milk. The most effective method was cryopreservation that ensured 100% viability for 2years.
December 2, 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27919528/laparoscopic-approach-to-the-treatment-of-type-ii-choledocal-cysts
#4
Aylhin López-Marcano, Roberto de la Plaza-Llamas, José Manuel Ramia, Farah Al-Shwely, Jhonny Gonzales-Aguilar, Anibal Medina Velasco
No abstract text is available yet for this article.
December 2, 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27919074/epigenetic-stress-responses-induce-muscle-stem-cell-ageing-by-hoxa9-developmental-signals
#5
Simon Schwörer, Friedrich Becker, Christian Feller, Ali H Baig, Ute Köber, Henriette Henze, Johann M Kraus, Beibei Xin, André Lechel, Daniel B Lipka, Christy S Varghese, Manuel Schmidt, Remo Rohs, Ruedi Aebersold, Kay L Medina, Hans A Kestler, Francesco Neri, Julia von Maltzahn, Stefan Tümpel, K Lenhard Rudolph
The functionality of stem cells declines during ageing, and this decline contributes to ageing-associated impairments in tissue regeneration and function. Alterations in developmental pathways have been associated with declines in stem-cell function during ageing, but the nature of this process remains poorly understood. Hox genes are key regulators of stem cells and tissue patterning during embryogenesis with an unknown role in ageing. Here we show that the epigenetic stress response in muscle stem cells (also known as satellite cells) differs between aged and young mice...
November 30, 2016: Nature
https://www.readbyqxmd.com/read/27918888/online-continuing-interprofessional-education-on-hospital-acquired-infections-for-latin-america
#6
Julio C Medina-Presentado, Alvaro Margolis, Lucia Teixeira, L Lorier, Ana C Gales, Graciela Pérez Sartori, Maura S Oliveira, Verónica Seija, Daniela Paciel, Rafael Vignoli, Silvia Guerra, Henry Albornoz, Zaida Arteta, Antonio Lopez-Arredondo, Sofía García
INTRODUCTION: Latin America is a large and diverse region, comprising more than 600 million inhabitants and one million physicians in over 20 countries. Resistance to antibacterial drugs is particularly important in the region. This paper describes the design, implementation and results of an international bi-lingual (Spanish and Portuguese) online continuing interprofessional interactive educational program on hospital-acquired infections and antimicrobial resistance for Latin America, supported by the American Society for Microbiology...
December 2, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27916506/quantification-of-biologically-active-o-prenylated-and-unprenylated-phenylpropanoids-in-dill-anethum-graveolens-anise-pimpinella-anisum-and-wild-celery-angelica-archangelica
#7
Vito Alessandro Taddeo, Salvatore Genovese, Philippe de Medina, Roberta Palmisano, Francesco Epifano, Serena Fiorito
An analytical strategy based on different extraction methodologies and HPLC with spectrophotometric (UV-vis) detection has been developed to investigate the presence of and to quantitate biologically active selected unprenylated and O-prenylated phenylpropanoids, namely umbelliferone, 4'-geranyloxyferulic acid, 7-isopentenyloxycoumarin, auraptene, and umbelliprenin in dill (Anethum graveolens L.), anise (Pimpinella anisum L.), and wild celery (Angelica archangelica L.). Absolute ethanol or 7:3 water/ethanol mixtures were seen to be the most powerful extraction solvents to perform "classic" maceration or ultrasound-assisted one in terms of yields in secondary metabolites...
November 27, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27915418/in-vivo-cns-infection-model-of-acanthamoeba-genotype-t4-the-early-stages-of-infection-lack-presence-of-host-inflammatory-response-and-are-a-slow-and-contact-dependent-process
#8
Maritza Omaña-Molina, Dolores Hernandez-Martinez, Raquel Sanchez-Rocha, Ulises Cardenas-Lemus, Citlaltepetl Salinas-Lara, Adolfo Rene Mendez-Cruz, Laura Colin-Barenque, Patricia Aley-Medina, Jesus Espinosa-Villanueva, Leticia Moreno-Fierros, Jacob Lorenzo-Morales
This study was developed in order to describe the early morphological events observed during the invasion of two pathogenic strains of Acanthamoeba (genotype T4); A. castellanii and A. culbertsoni, at the olfactory meatus and cerebral, pulmonary, renal, hepatic and splenic tissues levels, an in vivo invasion study. Histological and immunohistochemical description of the events at 24, 48, 72, and 96 h postintranasal inoculations of BALB/c mice was performed. A. castellanii showed a higher invasion rate than A...
December 3, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27915163/impact-of-transfusion-on-stroke-after-cardiovascular-interventions-meta-analysis-of-comparative-studies
#9
Debora Brascia, Noemi Garcia-Medina, Eeva-Maija Kinnunen, Tuomas Tauriainen, Juhani Airaksinen, Fausto Biancari
PURPOSE: To evaluate the impact of transfusion on the development of stroke after cardiovascular interventions. METHODS: A literature search was performed to identify comparative studies on the impact of blood transfusion on the occurrence of stroke after adult cardiac surgery and interventional cardiology procedures. RESULTS: Twenty-four studies compared the outcome of 80 283 patients who received and 2 260 709 patients who did not receive blood transfusion after cardiovascular interventions...
November 12, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27910811/ll-37-hnp-1-and-hbd2-3-modulate-the-secretion-of-cytokines-tnf-%C3%AE-il-6-ifn-%C3%AE-il-10-and-mmp1-in-human-primary-cell-cultures
#10
Carlos Erik Medina Santos, Carmen Nathaly López Hurtado, Bruno Rivas Santiago, Roberto Gonzalez-Amaro, Yolanda Guadalupe Cataño Cañizales, Margarita de la Luz Martínez Fierro, José Antonio Enciso-Moreno, Mariana Haydee García Hernández
The aim of this study was to evaluate the effects of the LL-37, HNP-1 and HBD2/3 peptides on cytokine and MMP production in human polymorphonuclear cells, mononuclear cells and chondrocytes. The levels of cytokines in supernatants from mononuclear and polymorphonuclear cell cultures were measured with a cytometric bead array by flow cytometry. Likewise, the levels of metalloproteinase/MMP-1, 3, and 13 were measured in supernatants from chondrocyte cultures using an ELISA. The expression of RANKL on lymphocytes was analyzed by flow cytometry...
September 1, 2016: European Cytokine Network
https://www.readbyqxmd.com/read/27908653/molecular-changes-in-children-with-heart-failure-undergoing-left-ventricular-assist-device-therapy
#11
Elizabeth Medina, Carmen C Sucharov, Penny Nelson, Shelley D Miyamoto, Brian L Stauffer
OBJECTIVE: To determine whether left ventricular assist device (LVAD) treatment in children with heart failure would result in the modification of molecular pathways involved in heart failure pathophysiology. STUDY DESIGN: Forty-seven explanted hearts from children were studied (16 nonfailing control, 20 failing, and 11 failing post-LVAD implantation [F-LVAD]). Protein expression and phosphorylation states were determined by receptor binding assays and Western blots...
November 29, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27905606/a-qm-mm-study-of-the-reaction-mechanism-of-human-%C3%AE-ketoacyl-reductase
#12
Fabiola E Medina, Rui P P Neves, Maria J Ramos, Pedro A Fernandes
Human fatty acid synthase (hFAS) is a multifunctional enzyme involved in a wide diversity of biological functions. For instance, it is a precursor of phospholipids and other complex processes such as the de novo synthesis of long chain fatty acid. Human FAS is also a component of biological membranes and it is implicated in the overexpression of several types of cancers. In this work, we describe the catalytic mechanism of β-ketoreductase (KR), which is a catalytic domain of the hFAS enzyme that catalyzes the reduction of β-ketoacyl to β-hydroxyacyl with the concomitant oxidation of the NADPH cofactor...
December 1, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27899419/progressive-cl-channel-defects-reveal-disrupted-skeletal-muscle-maturation-in-r6-2-huntington-s-mice
#13
Daniel R Miranda, Monica Wong, Shannon H Romer, Cynthia McKee, Gabriela Garza-Vasquez, Alyssa C Medina, Volker Bahn, Andrew D Steele, Robert J Talmadge, Andrew A Voss
Huntington's disease (HD) patients suffer from progressive and debilitating motor dysfunction. Previously, we discovered reduced skeletal muscle chloride channel (ClC-1) currents, inwardly rectifying potassium (Kir) channel currents, and membrane capacitance in R6/2 transgenic HD mice. The ClC-1 loss-of-function correlated with increased aberrant mRNA processing and decreased levels of full-length ClC-1 mRNA (Clcn1 gene). Physiologically, the resulting muscle hyperexcitability may help explain involuntary contractions of HD...
November 29, 2016: Journal of General Physiology
https://www.readbyqxmd.com/read/27899263/adalimumab-dose-escalation-is-effective-and-well-tolerated-in-crohn-s-disease-patients-with-secondary-loss-of-response-to-adalimumab
#14
Nicolas Duveau, Maria Nachury, Romain Gerard, Julien Branche, Vincent Maunoury, Medina Boualit, Pauline Wils, Pierre Desreumaux, Benjamin Pariente
BACKGROUND: Although adalimumab is effective in Crohn's disease, most patients experience a loss of response over time. The aim of the present study was to evaluate efficacy and safety of adalimumab dose escalation and identify predictors of a clinical response in Crohn's disease patients with a secondary loss of response. METHODS: We performed a retrospective and observational study including all Crohn's disease patients who underwent dose escalation of adalimumab after a secondary loss of response from 2007 to 2015...
November 14, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27899144/hypoxia-induced-responses-by-endothelial-colony-forming-cells-are-modulated-by-placental-growth-factor
#15
Michelle B Hookham, Imran H A Ali, Christina L O'Neill, Emer Hackett, Melanie H Lambe, Tina Schmidt, Reinhold J Medina, Sara Chamney, Bharathi Rao, Eibhlin McLoone, David Sweet, Alan W Stitt, Derek P Brazil
BACKGROUND: Endothelial colony-forming cells (ECFCs), also termed late outgrowth endothelial cells, are a well-defined circulating endothelial progenitor cell type with an established role in vascular repair. ECFCs have clear potential for cell therapy to treat ischaemic disease, although the precise mechanism(s) underlying their response to hypoxia remains ill-defined. METHODS: In this study, we isolated ECFCs from umbilical cord blood and cultured them on collagen...
November 29, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27896955/adsorption-and-reactive-desorption-on-metal-organic-frameworks-a-direct-strategy-for-lactic-acid-recovery
#16
Timothée Stassin, Helge Reinsch, Ben Van de Voorde, Stefan Wuttke, Dana D Medina, Norbert Stock, Thomas Bein, Rob Ameloot, Dirk De Vos
Biomass-derived lactic acid (LA) is an important platform chemical towards the sustainable production of numerous materials. However, the fermentation process currently in use is limited by the difficult recovery of the LA product from the fermentation broth and results in the generation of stoichiometric amounts of gypsum waste. Herein, we show that metal-organic frameworks (MOFs) of the UiO-66(Zr) type are effective adsorbents for the separation of LA from aqueous (buffer) solutions. These frameworks based on zirconium clusters and terephthalic acid derivatives display a tremendous uptake (up to 42 wt %) and a high affinity for LA...
November 29, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27895718/consensus-diversity-plots-a-global-diversity-analysis-of-chemical-libraries
#17
Mariana González-Medina, Fernando D Prieto-Martínez, John R Owen, José L Medina-Franco
BACKGROUND: Measuring the structural diversity of compound databases is relevant in drug discovery and many other areas of chemistry. Since molecular diversity depends on molecular representation, comprehensive chemoinformatic analysis of the diversity of libraries uses multiple criteria. For instance, the diversity of the molecular libraries is typically evaluated employing molecular scaffolds, structural fingerprints, and physicochemical properties. However, the assessment with each criterion is analyzed independently and it is not straightforward to provide an evaluation of the "global diversity"...
2016: Journal of Cheminformatics
https://www.readbyqxmd.com/read/27894157/relationship-between-serum-infliximab-concentrations-and-risk-of-infections-in-patients-treated-for-spondyloarthritis
#18
Theodora Bejan-Angoulvant, David Ternant, Fadela Daoued, Frédéric Medina, Louis Bernard, Saloua Mammou, Gilles Paintaud, Denis Mulleman
OBJECTIVE: Tumor necrosis factor inhibitors are effective in reducing inflammation in rheumatic diseases but increase the risk of infections. This study was undertaken to investigate the relationship between the trough serum concentration of infliximab (IFX) and the risk of a first infection episode. METHODS: We retrospectively included all patients who started IFX treatment for an approved indication in our department. Patients were followed up based on recommended IFX infusion schedules...
November 28, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27891247/librarians-and-scientists-partner-to-address-data-management-taking-collaboration-to-the-next-level
#19
Andrea Medina-Smith, Kimberly A Tryka, Barbara P Silcox, Robert J Hanisch
PURPOSE: This study looks at the changing way in which the Information Services Office (ISO) at the National Institute of Standards and Technology (NIST) provides services to NIST scientific and technical staff throughout their research and publishing cycles. These services include the more traditional services of a research library as well as publishing NIST technical reports and The Journal of Research of NIST, and preserving and exhibiting scientific instruments and other artifacts...
2016: Digit Libr Perspect
https://www.readbyqxmd.com/read/27890514/effectiveness-of-radiolabelled-somatostatin-analogues-90-y-dotatoc-and-177-lu-dotatate-in-patients-with-metastatic-neuroendocrine-tumours-a-single-centre-experience-in-mexico
#20
S S Medina-Ornelas, F O García-Pérez
OBJECTIVE: To determine the effectiveness of therapy with the radiolabelled somatostatin analogues, (90)Y-DOTATOC and (177)Lu-DOTATATE, in the treatment of metastatic neuroendocrine tumours with progression to first-line treatment. MATERIAL AND METHODS: A study was conducted on 30 patients diagnosed with neuroendocrine tumours (gastroenteropancreatic, bronchopulmonary, MEN2A, MEN2B, phaeochromocytoma, and paraganglioma) with metastatic disease diagnosed by the pathology department, with progression to first-line treatment, and recruited from December 2014 to February 2016...
November 24, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
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