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https://www.readbyqxmd.com/read/28813715/induction-of-cyclooxygenase-2-by-streptococcus-pyogenes-is-mediated-by-cytolysins
#1
Ulrike Blaschke, Andreas Beineke, Johanna Klemens, Eva Medina, Oliver Goldmann
Prostaglandin E2 (PGE2), an arachidonic acid metabolite regulating a broad range of physiological activities, is an important modulator of the severity of infection caused by Streptococcus pyogenes. Here, we investigated the role of streptococcal cytolysin S (SLS) and streptococcal cytolysin O (SLO) in the induction of cyclooxygenase-2 (COX-2), the rate-limiting enzyme in the synthesis of prostaglandins, in in vitro cultured macrophages and during in vivo infection. Macrophages were infected with S. pyogenes wild type or with the isogenic mutant strains deficient in SLS (ΔSLS), SLO (ΔSLO), or both (ΔSLS/ΔSLO), and the expression of COX-2 was determined at the transcriptional and the protein level...
August 17, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28812673/craniofacial-diversification-in-the-domestic-pigeon-and-the-evolution-of-the-avian-skull
#2
Nathan M Young, Marta Linde-Medina, John W Fondon, Benedikt Hallgrímsson, Ralph S Marcucio
A central question in evolutionary developmental biology is how highly conserved developmental systems can generate the remarkable phenotypic diversity observed among distantly related species. In part, this paradox reflects our limited knowledge about the potential for species to both respond to selection and generate novel variation. Consequently, the developmental links between small-scale microevolutionary variations within populations to larger macroevolutionary patterns among species remain unbridged...
March 13, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28811945/corrigendum-to-prenatal-diagnosis-of-cardiac-diverticulum-with-pericardial-effusion-in-the-first-trimester-of-pregnancy-with-resolution-after-early-pericardiocentesis
#3
Raquel Garcia Rodriguez, Azahara Rodriguez Guedes, Raquel Garcia Delgado, Lourdes Roldan Gutierrez, Margarita Medina Castellano, Jose Angel Garcia Hernandez
[This corrects the article DOI: 10.1155/2015/154690.].
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28810982/evaluation-of-the-validity-and-response-burden-of-patient-self-report-measures-of-the-pain-assessment-screening-tool-and-outcomes-registry-pastor
#4
Karon F Cook, Michael A Kallen, Chester Buckenmaier, Diane M Flynn, Steven R Hanling, Teresa S Collins, Kristin Joltes, Kyung Kwon, Sheila Medina-Torne, Parisa Nahavandi, Joshua Suen, Richard Gershon
BACKGROUND: In 2009, the Army Pain Management Task Force was chartered. On the basis of their findings, the Department of Defense recommended a comprehensive pain management strategy that included development of a standardized pain assessment system that would collect patient-reported outcomes data to inform the patient-provider clinical encounter. The result was the Pain Assessment Screening Tool and Outcomes Registry (PASTOR). The purpose of this study was to assess the validity and response burden of the patient-reported outcome measures in PASTOR...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28807581/right-heart-function-during-and-after-community-acquired-pneumonia-in-adults
#5
Kevin E Boczar, Vicente F Corrales-Medina, Ian G Burwash, Julio A Chirinos, Girish Dwivedi
BACKGROUND: New-onset or worsening heart failure is the most common extra-pulmonary complication of community-acquired pneumonia (CAP) during the first 30 days after diagnosis. METHODS: We evaluated the changes in the right ventricular function amongst adult CAP survivors from the time of acute infection to its resolution. We performed comprehensive transthoracic echocardiographic examinations to assess right heart function during the acute illness and the convalescent period (four to six weeks after hospital discharge)...
July 27, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28806334/cochlear-implantation-in-postlingual-adult-patients-with-long-term-auditory-deprivation
#6
Maria Del Mar Medina, Ruben Polo, Auxiliadora Gutierrez, Alfonso Muriel, Miguel Vaca, Cecilia Perez, Adela Cordero, Ignacio Cobeta
OBJECTIVE: The role of long-term hearing deprivation in cochlear implant performance is not well established, and the limits for implanting an auditory deprived ear are still unknown. The objective of this study was to evaluate the effect of long-term auditory deprivation time on cochlear implant results. STUDY DESIGN: Retrospective case review study. SETTING: Cochlear implantation tertiary referral center. PATIENTS: Adult patients with postlingual deafness...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28803432/quality-of-life-in-home-ventilated-children-and-their-families
#7
Rafael González, Amaya Bustinza, Sarah N Fernandez, Miriam García, Silvia Rodriguez, Ma Ángeles García-Teresa, Mirella Gaboli, Silvia García, Olaia Sardón, Diego García, Antonio Salcedo, Antonio Rodríguez, Ma Carmen Luna, Arturo Hernández, Catalina González, Alberto Medina, Estela Pérez, Alicia Callejón, Juan D Toledo, Mercedes Herranz, Jesús López-Herce
HMV (home mechanical ventilation) in children has increased over the last years. The aim of the study was to assess perceived quality of life (QOL) of these children and their families as well as the problems they face in their daily life.We performed a multicentric cross-sectional study using a semi-structured interview about the impact of HMV on families and an evaluation questionnaire about perceived QOL by the patient and their families (pediatric quality of life questionnaire (PedsQL4.0)). We studied 41 subjects (mean age 8...
August 12, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28802670/chemoselective-fluorination-and-chemoinformatic-analysis-of-griseofulvin-natural-vs-fluorinated-fungal-metabolites
#8
Noemi D Paguigan, Mohammed H Al-Huniti, Huzefa A Raja, Austin Czarnecki, Joanna E Burdette, Mariana González-Medina, José L Medina-Franco, Stephen J Polyak, Cedric J Pearce, Mitchell P Croatt, Nicholas H Oberlies
Griseofulvin is a fungal metabolite and antifungal drug used for the treatment of dermatophytosis in both humans and animals. Recently, griseofulvin and its analogues have attracted renewed attention due to reports of their potential anticancer effects. In this study griseofulvin (1) and related analogues (2-6, with 4 being new to literature) were isolated from Xylaria cubensis. Six fluorinated analogues (7-12) were synthesized, each in a single step using the isolated natural products and Selectflour, so as to examine the effects of fluorine incorporation on the bioactivities of this structural class...
July 28, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28802325/snomed2hl7-a-tool-to-normalize-and-bind-snomed-ct-concepts-to-the-hl7-reference-information-model
#9
D Perez-Rey, R Alonso-Calvo, S Paraiso-Medina, C R Munteanu, M Garcia-Remesal
BACKGROUND: Current clinical research and practice requires interoperability among systems in a complex and highly dynamic domain. There has been a significant effort in recent years to develop integrative common data models and domain terminologies. Such efforts have not completely solved the challenges associated with clinical data that are distributed among different and heterogeneous institutions with different systems to encode the information. Currently, when providing homogeneous interfaces to exploit clinical data, certain transformations still involve manual and time-consuming processes that could be automated...
October 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28800094/socioeconomic-inequalities-in-visits-to-the-dentist-to-receive-professionally-applied-topical-fluoride-in-a-developing-country
#10
Miriam Del Socorro Herrera, Carlo Eduardo Medina-Solís, América Patricia Pontigo-Loyola, Rubén de la Rosa-Santillana, Leticia Ávila-Burgos, Rogelio José Scougall-Vilchis, Sonia Márquez-Rodríguez, Mirna Minaya-Sánchez, Alejandro José Casanova-Rosado
OBJECTIVE: To determine the frequency and associated factors of visits to the dentist in the last year by Nicaraguan schoolchildren to receive professionally applied topical fluoride (PATF). MATERIAL AND METHODS: A cross-sectional study was designed in children from public schools in the city of León, Nicaragua, were included. A series of socioeconomic, sociodemographic, and behavioural variables were collected through a questionnaire. The dependent variable was the visit to the dentist to receive professionally applied topical fluoride in the last year, which was dichotomised as (0) Did not receive PATF and (1) Yes received PATF...
August 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28799824/high-prevalence-of-asymptomatic-sexually-transmitted-infections-among-human-immunodeficiency-virus-infected-pregnant-women-in-a-low-income-south-african-community
#11
Maanda Mudau, Remco P Peters, Lindsey De Vos, Dawie H Olivier, Dvora J Davey, Edwin S Mkwanazi, James A McIntyre, Jeffrey D Klausner, Andrew Medina-Marino
There is a lack of evidence on the burden of Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) among HIV-infected pregnant women in South Africa. We conducted a cross-sectional analysis of HIV-infected pregnant women in two healthcare facilities in a South African township to determine the prevalence of CT, NG and TV. HIV-infected pregnant women were recruited during the first antenatal care visit for their current pregnancy and requested to self-collect vulvovaginal swab specimens...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28797377/pain-in-the-elderly-identification-evaluation-and-management-of-older-adults-with-pain-complaints-and-pain-related-symptoms
#12
REVIEW
Andrew Dentino, Roberto Medina, Eugene Steinberg
Pain is a common and often underappreciated and undermanaged problem in older adults. This article addresses the scope of the issue of pain prevalence in older adults, types of pain and their characteristics, approach to and clinical workup of older adults with pain complaints and pain-related symptoms, nonpharmacologic and pharmacologic management strategies, and caveats with attention to medication side effects in the elderly.
September 2017: Primary Care
https://www.readbyqxmd.com/read/28796503/effect-of-processing-on-the-in-vitro-and-in-vivo-protein-quality-of-yellow-and-green-split-peas-pisum-sativum
#13
Matthew G Nosworthy, Adam Franczyk, Gerardo Medina, Jason Neufeld, Paulyn Appah, Alphonsus Utioh, Peter Frohlich, James Duncan House
In order to determine the effect of extrusion, baking and cooking on the protein quality of yellow and green split peas, a rodent bioassay was conducted and compared to an in vitro method of protein quality determination. The Protein Digestibility-Corrected Amino Acid Score (PDCAAS) of green split peas (71.4%) was higher than that of yellow split peas (67.8%), on average. Similarly, the average Digestible Indispensable Amino Acid Score (DIAAS) of green split peas (69%) was higher than that of yellow split peas (67%)...
August 10, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28794926/solid-bioprocess-of-tarbush-flourensia-cernua-leaves-for-%C3%AE-glucosidase-production-by-aspergillus-niger-initial-approach-to-fiber-glycoside-interaction-for-enzyme-induction
#14
Juan Lopez-Trujillo, Miguel A Medina-Morales, Ariel Sanchez-Flores, Carlos Arevalo, Juan A Ascacio-Valdes, Miguel Mellado, Cristobal N Aguilar, Antonio F Aguilera-Carbo
Commercial cellulase production has increased in recent years and consistent research has been carried out to improve levels of β-glucosidase. Bioprocesses have been successfully adapted to produce this enzyme, with solid-state fermentations as the best-suited technique involving fungi. The aim of this study was to use leaves of tarbush (Flourensia cernua), an abundant shrub of the Chihuahuan Desert, as a carbon source for β-glucosidase production by Aspergillus niger. During the solid bioprocess, this enzyme reached its peak production at 36 h of culture with 3876...
August 2017: 3 Biotech
https://www.readbyqxmd.com/read/28794856/chemmaps-towards-an-approach-for-visualizing-the-chemical-space-based-on-adaptive-satellite-compounds
#15
J Jesús Naveja, José L Medina-Franco
We present a novel approach called ChemMaps for visualizing chemical space based on the similarity matrix of compound datasets generated with molecular fingerprints' similarity. The method uses a 'satellites' approach, where satellites are, in principle, molecules whose similarity to the rest of the molecules in the database provides sufficient information for generating a visualization of the chemical space. Such an approach could help make chemical space visualizations more efficient. We hereby describe a proof-of-principle application of the method to various databases that have different diversity measures...
2017: F1000Research
https://www.readbyqxmd.com/read/28793018/prevalence-of-hepatitis-b-and-c-virus-infection-among-alcoholic-individuals-importance-of-screening-and-vaccination
#16
Vanessa Faria Cortes, Angela Taveira, Helena Medina Cruz, Amanda Alves Reis, Jéssica Silva Cezar, Brener Santos Silva, Cintia Feliciano D'Assunção, Elisabeth Lampe, Livia Melo Villar
Drug users have been reported to have an increased risk for acquisition of viral hepatitis. This study aims to evaluate the prevalence of HBV and HCV infection and usefulness of saliva for HBsAg and anti-HCV detection in alcoholic patients.A total of 90 alcoholic patients were recruited in 2013. HBsAg and anti-HCV were tested in serum and saliva, anti-HBc and anti-HBs were tested in serum using commercial enzyme immunoassays (EIA).Using serum samples, anti-HCV, HBsAg, anti-HBc and anti-HBs prevalences were 5...
2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28790457/the-fad-synthetase-from-the-human-pathogen-streptococcus-pneumoniae-a-bifunctional-enzyme-exhibiting-activity-dependent-redox-requirements
#17
María Sebastián, Erandi Lira-Navarrete, Ana Serrano, Carlos Marcuello, Adrián Velázquez-Campoy, Anabel Lostao, Ramón Hurtado-Guerrero, Milagros Medina, Marta Martínez-Júlvez
Prokaryotic bifunctional FAD synthetases (FADSs) catalyze the biosynthesis of FMN and FAD, whereas in eukaryotes two enzymes are required for the same purpose. FMN and FAD are key cofactors to maintain the flavoproteome homeostasis in all type of organisms. Here we shed light to the properties of the hitherto unstudied bacterial FADS from the human pathogen Streptococcus pneumoniae (SpnFADS). As other members of the family, SpnFADS catalyzes the three typical activities of prokaryotic FADSs: riboflavin kinase (RFK), ATP:FMN:adenylyltransferase (FMNAT), and FAD pyrophosphorylase (FADpp)...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28789978/a-composite-indicator-to-assess-the-quality-of-care-in-the-management-of-patients-with-rheumatoid-arthritis-in-outpatient-rheumatology-clinics
#18
María Auxiliadora Martín-Martínez, Jose Luis Andreu-Sanchez, Fernando Sanchez-Alonso, Hector Corominas, Jose Javier Perez-Venegas, Jose Andres Roman-Ivorra, Mercedes Alperi, Ricardo Blanco-Alonso, Rafael Caliz, Eugenio Chamizo-Carmona, Jenaro Graña-Gil, Blanca Hernández, Carlos Marras, Ramon Mazzucchelli, Julio Antonio Medina Luezas, Antonio Naranjo-Hernández, Ana Ortiz, Rosa Roselló, Ginés Sanchez-Nievas, Raimon Sanmartí, Paloma Vela-Casasempere
OBJECTIVE: The current guidelines in the treatment of rheumatoid arthritis (RA) include the early diagnosis and early use of disease modifying drugs to achieve remission or low disease activity level, known as "Treat to Target" (T2T). The objective of this study is to develop a composite indicator (CI) to evaluate the quality of care in the management of patients with RA, according to the T2T strategy and other general recommendations concerning the management of these patients. MATERIAL AND METHOD: The phases of the construction of the CI were: 1) selection of quality criteria through expert judgment; 2) prioritization of the criteria, according to relevance and feasibility, applying the Delphi methodology (two rounds) involving 20 experts; 3) design of quality indicators; and 4) calculation of the weighted CI, using the mean value in relevance and feasibility granted by the experts...
August 5, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28783029/revised-classification-of-the-subfamily-leishmaniinae-trypanosomatidae
#19
Alexei Y Kostygov, Vyacheslav Yurchenko
In the present study, we critically revised the recently proposed classification of the subfamily Leishmaniinae Maslov et Lukeš in Jirků et al., 2012. Agreeing with erection of the genus Zelonia Shaw, Camargo et Teixeira in Espinosa et al., 2017 and the subgenus Mundinia Shaw, Camargo et Teixeira in Espinosa et al., 2017 within the genus Leishmania Ross, 1908, we argue that other changes are not well justified. We propose to: (i) raise Paraleishmania Cupolillo, Medina-Acosta, Noyes, Momen et Grimaldi, 2000 to generic rank; (ii) create a new genus Borovskyia gen...
July 10, 2017: Folia Parasitologica
https://www.readbyqxmd.com/read/28782674/high-prevalence-of-ibuprofen-drug-induced-liver-injury-in-spanish-and-latin-american-registries
#20
Miguel E Zoubek, Andres González-Jimenez, Inmaculada Medina-Cáliz, Mercedes Robles-Díaz, Nelia Hernandez, Manuel Romero-Gómez M, Fernando Bessone, Hacibe Hallal, Francisco J Cubero, M Isabel Lucena, Camilla Stephens, Raúl J Andrade
No abstract text is available yet for this article.
August 3, 2017: Clinical Gastroenterology and Hepatology
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