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spinal cord tumours

Marcel Ivanov, Alexandru Budu, Hugh Sims-Williams, Ion Poeata
BACKGROUND: Our aim was to evaluate the utility of modern intraoperative ultrasound in the resection of a wide variety of spinal intradural pathological entities. MATERIALS AND METHODS: The authors evaluated patients with spinal cord pathology treated between January 2006 and September 2015. Intraoperative standard B-mode images were acquired using a 3.5-12 MHz US probes (linear and curvilinear) on various ultrasound machines. The benefits and disadvantages of intraoperative ultrasound (iUS) were assessed for each case...
October 3, 2016: World Neurosurgery
Maria Teresa Mandara, Luca Motta, Pietro Calò
In cats, lymphoma (lymphosarcoma) is the most common neoplasm affecting the spinal cord and the second most common intracranial tumour. Although lymphoma commonly develops in the spinal cord as a part of a multicentric process, a primary form may occur. Lymphoma can exhibit a wide range of morphological patterns, including intraparenchymal brain mass, lymphomatosis cerebri, intravascular lymphoma, lymphomatous choroiditis and meningitis, extradural, intradural-extramedullary or intramedullary lymphoma in the spinal cord, or neurolymphomatosis in the peripheral nerves...
October 2016: Veterinary Journal
Krishna Chaitanya Joshi, Kiran Khanapure, Nishchit Hegde, Niveditha Ravindra, Aniruddha T Jagannatha, Alangar S Hegde
BACKGROUND: Angiogliomas are rare low-grade glial tumors with significant vascular components. These tumors are usually seen in the brain, and spinal cord angiogliomas have not been reported in the literature until now. CASE DESCRIPTION: We report the case of a 15-year-old boy with an angioglioma of the medulla and cervicodorsal spine, which was completely excised through a combined suboccipital craniotomy and cervicodorsal laminotomy. The patient experienced excellent clinical recovery after the surgery, and follow-up contrast magnetic resonance imaging showed complete excision of the tumor...
September 15, 2016: World Neurosurgery
Daniëlle B P Eekers, Erik Roelofs, Urszula Jelen, Maura Kirk, Marlies Granzier, Filippo Ammazzalorso, Peter H Ahn, Geert O R J Janssens, Frank J P Hoebers, Tobias Friedmann, Timothy Solberg, Sean Walsh, Esther G C Troost, Johannes H A M Kaanders, Philippe Lambin
BACKGROUND AND PURPOSE: In this multicentric in silico trial we compared photon, proton, and carbon-ion radiotherapy plans for re-irradiation of patients with squamous cell carcinoma of the head and neck (HNSCC) regarding dose to tumour and doses to surrounding organs at risk (OARs). MATERIAL AND METHODS: Twenty-five HNSCC patients with a second new or recurrent cancer after previous irradiation (70Gy) were included. Intensity-modulated proton therapy (IMPT) and ion therapy (IMIT) re-irradiation plans to a second subsequent dose of 70Gy were compared to photon therapy delivered with volumetric modulated arc therapy (VMAT)...
September 14, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Pedro David Delgado-López, Antonio Rodríguez-Salazar, Vicente Martín-Velasco, José Manuel Castilla-Díez, Javier Martín-Alonso, Ana Galacho-Harriero, Cecilia Gil-Polo, Elena Araus-Galdós
OBJECTIVE: To describe the specific surgical details and report the lessons learned with a series of patients suffering from spinal tumours that underwent total en bloc spondylectomy (TES). METHODS: A retrospective case series review is presented, together with an analysis of the clinical and technical variables, as well as the outcomes. RESULTS: A total of 10 patients underwent TES (2000-2016) for primary (osteosarcoma, chondrosarcoma, fibrosarcoma and chordoma) and secondary spinal tumours (lung, breast, thyroid, oesophagus, and meningioma metastases)...
September 14, 2016: Neurocirugía
D Pasquier, G Martinage, X Mirabel, T Lacornerie, S Makhloufi, J-C Faivre, S Thureau, É Lartigau
After the liver and lungs, bones are the third most common sites of cancer metastasis. Palliative radiotherapy for secondary bone tumours helps relieve pain, improve the quality of life and reduce the risk of fractures. Stereotactic body radiotherapy can deliver high radiation doses with very tight margins, which has significant advantages when treating tumours close to the spinal cord. Strict quality control is essential as dose gradient at the edge of the spinal cord is important. Optimal schedule is not defined...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
M Zysman, C Clement-Duchene, C Bastien, P Vaillant, Y Martinet
INTRODUCTION: Rhabdoid tumours usually develop in brain and spinal cord or kidney; they are highly malignant neoplasms that typically arise in infancy and early childhood. However, rare cases of pulmonary localization have been described, particularly among young adults. CASE REPORT: A 26-year-old man, smoker, had a right apical lung mass associated with a Pancoast syndrome leading to haemoptysis. There was also a tumour of the left thigh and scalp. Histological samples taken at these three locations were in favour of an undifferentiated carcinoma...
August 29, 2016: Revue des Maladies Respiratoires
I Martinez-Albaladejo, M Prochazkova, I Perez-Sebastian, B Bernardino-Cuesta, C Martinez-Ferrandez, O M Suarez-Traba, M Budke, J J Garcia-Penas
INTRODUCTION: Syringomyelia is defined as a cavity containing cerebrospinal fluid inside the spinal cord. AIM: To describe the clinical characteristics of a series of patients with syringomyelia, as well as its diagnosis and treatment. PATIENTS AND METHODS: We conducted a retrospective descriptive study by reviewing the medical records at our centre. RESULTS: We reviewed 25 patients diagnosed with syringomyelia. In five cases, the diagnosis was reached casually, and eight of them presented a previous severe pathology (tumour, bone or vascular)...
September 1, 2016: Revista de Neurologia
B Clavo, F Robaina, D Fiuza, A Ruiz, M Lloret, D Rey-Baltar, P Llontop, A Riveros, J Rivero, F Castañeda, S Quintero, N Santana-Rodríguez
PURPOSE: Hypoxia has predictive value in head and neck cancer (HNC). It has been well described, albeit in a small number of clinical Centres. The aim of this study was to describe our experience using the polarographic probe technique to assess the predictive value of tumour oxygenation in patients with advanced HNC treated with hyperfractionated radio-chemotherapy. Hypoxia modification was induced using percutaneous spinal cord stimulation (SCS). METHODS/PATIENTS: Male patients (n = 12; stage IVb n = 8; IVa n = 4; mean age 58: range 46-70 years) with advanced HNC were evaluated...
August 15, 2016: Clinical & Translational Oncology
Vincenzo Denaro, Luca Denaro, Erika Albo, Nicola Papapietro, Andrea Piccioli, Alberto Di Martino
INTRODUCTION: Multiple Myeloma (MM) typically involves the spine and causes bone pain, pathological fractures and spinal cord compression with possible consequent neurological deficits. This retrospective study reports the results of surgery on a selected population of patients who underwent surgery for symptomatic spinal myeloma. MATERIALS AND METHODS: A total of 26 patients who underwent surgery for spinal myeloma with neurological involvement were studied retrospectively...
August 6, 2016: Injury
X-T Deng, M-Z Wu, N Xu, P-C Ma, X-J Song
BACKGROUND: Diabetic neuropathic pain (DNP) is severe and intractable in clinic. The specific cellular and molecular mechanisms underlying DNP remain elusive and its treatment are limited. We investigated roles of EphB1 receptor in the development of DNP. METHODS: Diabetic neuropathic pain was produced in male, adult, Sprague-Dawley rats by a single i.p. streptozotocin (STZ) or alloxan. Western blot analysis and immunohistochemistry were used to analyse expression of EphB1 receptor as well as the activation of the glial cells and the pro-inflammatory cytokines in the spinal cord...
July 27, 2016: European Journal of Pain: EJP
Elena A Kaye, Sebastien Monette, Govindarajan Srimathveeravalli, Majid Maybody, Stephen B Solomon, Amitabh Gulati
PURPOSE: About 10-40% of chronic low back pain cases involve facet joints, which are commonly treated with lumbar medial branch (MB) radiofrequency neurotomy. Magnetic resonance imaging-guided focused ultrasound (MRgFUS), a non-invasive, non-ionising ablation modality used to treat tumours, neuropathic pain and painful bone metastasis can also be used to disrupt nerve conduction. This work's purpose was to study the feasibility and safety of direct MRgFUS ablation of the lumbar MB nerve in acute and subacute swine models...
November 2016: International Journal of Hyperthermia
Nives Pećina-Šlaus, Anja Kafka, Mirna Lechpammer
Research over the last decade recognized the importance of novel molecular pathways in pathogenesis of intracranial meningiomas. In this review, we focus on human brain tumours meningiomas and the involvement of Wnt signalling pathway genes and proteins in this common brain tumour, describing their known functional effects. Meningiomas originate from the meningeal layers of the brain and the spinal cord. Most meningiomas have benign clinical behaviour and are classified as grade I by World Health Organization (WHO)...
2016: Cancers
Simon Davies, Barbara Gregson, Patrick Mitchell
BACKGROUND: The aim of this study was to find the relationships between the degree of cord compression as seen on MRIs with persisting cord atrophy after decompression and patient outcomes in spinal meningiomas. METHOD: We undertook a retrospective analysis of 31 patients' pre- and postoperative MRIs, preoperative functional status and their outcomes at follow-up. The following metrics were analysed; percentage cord area at maximum compression, percentage tumour occupancy and percentage cord occupancy...
July 8, 2016: British Journal of Neurosurgery
Amr El Kouny, Mohammed Al Harbi, Rashid Muhammad Arif, Nazar Ilyas, El Abbasy Omar Hamed, Maqsood Memon, Ali Nawaz, Vassilios Dimitriou
A 52 yearold female presented with a thoracic paravertebral tumour causing spinal nerve root compression and lower limbs neurologic symptoms. The patient was scheduled to undergo thoracic decompression laminectomy and instrumentation. Markedly severe hemodynamic fluctuations happened during the manipulation of the tumor and continued after the tumor was removed. After multimodal antihypertensive therapy the vital signs were adequately managed and the surgery was successfully performed without complications...
February 2016: Middle East Journal of Anesthesiology
James Knight, Leslie R Bridges, Pawanjit S Minhas, George Eralil
We present a very rare case of a metastasising pleomorphic adenoma with spinal cord compression and review the small handful of cases with central nervous system (CNS) involvement in the literature. This case is unusual as most other reported cases are preceded by local recurrences; also, there is only one previous case of an MPA presenting with spinal cord compression. Metastasising pleomorphic adenoma is a rare malignant salivary gland tumour which, despite "benign" histological appearances produces secondary deposits in distant sites...
June 22, 2016: British Journal of Neurosurgery
Giuseppe Mariniello, Francesca Malacario, Flavia Dones, Rocco Severino, Lorenzo Ugga, Camilla Russo, Andrea Elefante, Francesco Maiuri
Spinal meningiomas usually present with slowly progressive symptoms of cord and root compression, while a sudden clinical onset is very rare. A 35-year-old previously symptom-free woman presented sudden right sciatica and weakness of her right leg following a fall with impact to her left foot. A neurological examination showed paresis of the right quadriceps, tibial and sural muscles, increased bilateral knee and ankle reflexes and positive Babinski sign. Magnetic resonance imaging (MRI) revealed the presence of a spinal T11 meningioma in the left postero-lateral compartment of the spinal canal; at this level, the spinal cord was displaced to the contralateral side with the conus in the normal position...
October 2016: Neuroradiology Journal
Rashi Garg, Shreya Shrivastav, Pranab Dey
Spinal echinococcal cyst is very uncommon and may have variable clinical presentations. We describe an exceptional case of intradural and extramedullary spinal echinococcal cyst, misguided as a spinal tumour on radiological examination and was diagnosed as echinococcal cyst on fine needle aspiration biopsy smears and subsequently on histopathological examination.
2016: Annals of Parasitology
H Wang, Y Huang, P Nie, C Dong, F Hou, D Hao, W Xu
AIM: To characterise and evaluate magnetic resonance imaging (MRI) images for their clinical value in diagnosing and assessing intraspinal mature teratoma. MATERIALS AND METHODS: MRI images obtained from eight patients with a histopathologically verified intraspinal mature teratoma were analysed retrospectively regarding tumour location, size, and margins. Additionally, the signal intensity and enhancement pattern on MRI and other associated malformations were also assessed...
July 2016: Clinical Radiology
R Hampel, F Taylor-Brown, S L Priestnall
A 9-year-old, neutered female Maine Coon cat with a 6-week history of progressive ataxia was diagnosed with a cervical vertebral body mass using magnetic resonance imaging. The mass displaced and compressed the cervical spinal cord. The cat was humanely destroyed and necropsy examination confirmed a mass within the second cervical vertebral body. Microscopically, the mass was composed of large, clear, vacuolated ('physaliferous') cells. Immunohistochemically, the neoplastic cells expressed both cytokeratin and vimentin and the final diagnosis was a cervical, vertebral body chordoma...
May 2016: Journal of Comparative Pathology
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