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https://www.readbyqxmd.com/read/28220461/new-generation-coronary-stents-current-data-and-future-directions
#1
REVIEW
Ankur Kalra, Hasan Rehman, Sahil Khera, Braghadheeswar Thyagarajan, Deepak L Bhatt, Neal S Kleiman, Robert W Yeh
PURPOSE OF REVIEW: Drug-eluting stents are the mainstay in the treatment of coronary artery disease using percutaneous coronary intervention. Innovations developed to overcome the limitations of prior generations of stents include biodegradable polymer stents, drug-eluting stents without a polymer, and bioabsorbable scaffolds. Our review briefly discusses the clinical profiles of first- and second-generation coronary stents, and provides an up-to-date overview of design, technology, and clinical safety and efficacy profiles of newer generation coronary stents discussing the relevant clinical trials in this rapidly evolving area of interventional cardiology...
March 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28208634/rna-eluting-surfaces-for-the-modulation-of-gene-expression-as-a-novel-stent-concept
#2
Olivia Koenig, Diane Zengerle, Nadja Perle, Susanne Hossfeld, Bernd Neumann, Andreas Behring, Meltem Avci-Adali, Tobias Walker, Christian Schlensak, Hans Peter Wendel, Andrea Nolte
Presently, a new era of drug-eluting stents is continuing to improve late adverse effects such as thrombosis after coronary stent implantation in atherosclerotic vessels. The application of gene expression-modulating stents releasing specific small interfering RNAs (siRNAs) or messenger RNAs (mRNAs) to the vascular wall might have the potential to improve the regeneration of the vessel wall and to inhibit adverse effects as a new promising therapeutic strategy. Different poly (lactic-co-glycolic acid) (PLGA) resomers for their ability as an siRNA delivery carrier against intercellular adhesion molecule (ICAM)-1 with a depot effect were tested...
February 10, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28163838/longitudinal-deformation-of-a-third-generation-zotarolimus-eluting-stent-the-concertina-returns
#3
Vasileios F Panoulas, Ozan M Demir, Neil Ruparelia, Iqbal Malik
In the current case series we describe two cases of longitudinal stent deformation in ostial lesions treated with a new generation zotarolimus eluting stent and review current literature on longitudinal stent deformation. Historically not a common occurrence, longitudinal deformation occurred mainly in Promus Element everolimus eluting stents, which had only two rather than the commonly used 3 links between stent rings. Longitudinal deformation commonly occurs secondary to compression of the proximal edge of the stent by either the guide catheters, or intravascular balloons and imaging catheters...
January 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28163518/double-barrel-y-configuration-stenting-for-flow-diversion-of-a-giant-recurrent-basilar-apex-aneurysm-with-the-pipeline-flex-embolization-device
#4
Dale Ding, Robert M Starke, Ben McGuinness, Stefan Brew
Giant basilar apex aneurysms are extremely challenging to successfully manage. The Pipeline Flex embolization device (PFED) is a new generation flow-diverting stent with a modified delivery system which allows resheathing of the stent after partial deployment. We describe a case of double-barrel Y-configuration stenting of a giant, recurrent basilar apex aneurysm using the PFED. A 73-year-old male was previously treated for an unruptured 11-mm basilar apex aneurysm with stent-assisted coiling using a Neuroform stent...
December 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28104206/randomized-multicenter-trial-investigating%C3%A2-angiographic-outcomes-of%C3%A2-hybrid-sirolimus-eluting-stents-with%C3%A2-biodegradable-polymer-compared-with%C3%A2-everolimus-eluting-stents-with-durable%C3%A2-polymer-in-chronic-total-occlusions-the-prison-iv-trial
#5
Koen Teeuwen, René J van der Schaaf, Tom Adriaenssens, Jacques J Koolen, Pieter C Smits, José P S Henriques, Paul H M J Vermeersch, R Melvyn Tjon Joe Gin, Bastiaan E Schölzel, Johannes C Kelder, Jan G P Tijssen, Pierfrancesco Agostoni, Maarten J Suttorp
OBJECTIVES: The aim of this study was to investigate the efficacy and safety of the hybrid ultrathin-strut sirolimus-eluting stent (SES) with biodegradable polymer compared with the thin-strut everolimus-eluting stent (EES) with durable polymer in successfully recanalized chronic total occlusions (CTOs). BACKGROUND: The introduction of drug-eluting stents revolutionized the treatment of CTOs. However, limited data are available on new-generation drug-eluting stents with biodegradable polymer in CTOs...
January 23, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28089777/bioresorbable-vascular-scaffold-to-treat-malignant-in-stent-restenosis-in-a-patient-with-nickel-allergy
#6
Alfonso Jurado-Román, María T López-Lluva, Ignacio Sánchez-Pérez, Jesús Piqueras-Flores, Ramón Maseda, Fernando Lozano-Ruíz-Poveda
Nickel is the most frequent allergen in patients with allergic contact dermatitis and nickel allergy has been associated with recurrent in-stent restenosis. However, it is often misdiagnosed because of a low suspicion threshold. It should be discarded in patients with recurrent in-stent restenosis, especially if their medical history reveals prior contact dermatitis. It is also noteworthy and rarely specified that even newer generation stents that use novel metal alloys also contain low amounts of nickel. To avoid the implantation of new stents containing this metal, when percutaneous coronary intervention is indicated, drug eluting balloons or bioresorbable vascular scaffolds associated with small doses of steroids could provide good alternatives of treatment...
January 2, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28067198/outcomes-of-patients-treated-with-durable-polymer-platinum-chromium-everolimus-eluting-stents-a-meta-analysis-of-randomized-trials
#7
Salvatore Cassese, Gjin Ndrepepa, Robert A Byrne, Sebastian Kufner, Erion Xhepa, Antoinette de Waha, Tobias Rheude, Roisin Colleran, Daniele Giacoppo, Yukinori Harada, Karl-Ludwig Laugwitz, Heribert Schunkert, Massimiliano Fusaro, Adnan Kastrati
AIMS: The durable-polymer platinum-chromium everolimus-eluting stent (PtCr-EES) is a new- generation drug-eluting stent (DES) with a platinum-enriched metallic platform developed to improve the percutaneous treatment of patients with coronary artery disease. We sought to investigate the performance of durable-polymer PtCr-EES versus other new-generation DES. METHODS AND RESULTS: We undertook a meta-analysis of trials, in which patients receiving percutaneous coronary intervention (PCI) were randomly assigned to durable-polymer PtCr-EES versus other new-generation DES (other DES)...
January 10, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28039928/comparison-of-early-and-new-generation-drug-eluting-stent-implantations-for-ostial-right-coronary-artery-lesions
#8
Yusuke Watanabe, Kensuke Takagi, Toru Naganuma, Sunao Nakamura
BACKGROUND: Percutaneous coronary intervention (PCI) with early generation drug-eluting stent (eDES) implantation for ostial right coronary artery (RCA) lesions is challenging because of the frequent need for repeat revascularization. We compared mid-term clinical outcomes following eDES or new generation DES (nDES) implantation for ostial RCA lesions. METHODS: The study included 150 patients with ostial RCA lesions, 76 treated with eDES and 74 with nDES between January 2005 and September 2013...
December 31, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28039573/calcified-nodule-as-an-unsolved-cause-of-coronary-stent-thrombosis-in-the-new-generation-drug-eluting-stent-era
#9
Kazuhiko Yumoto, Tsubasa Kanaya, Shingo Tanaka, Tomoyuki Fukuzawa, Takahiro Watanabe, Hajime Aoki
No abstract text is available yet for this article.
December 30, 2016: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28013101/ex-vivo-blood-vessel-bioreactor-for-analysis-of-the-biodegradation-of-magnesium-stent-models-with-and-without-vessel-wall-integration
#10
Juan Wang, Lumei Liu, Yifan Wu, Manfred F Maitz, Zhihong Wang, Youngmi Koo, Ansha Zhao, Jagannathan Sankar, Deling Kong, Nan Huang, Yeoheung Yun
: Current in vitro models fail in predicting the degradation rate and mode of magnesium (Mg) stents in vivo. To overcome this, the microenvironment of the stent is simulated here in an ex vivo bioreactor with porcine aorta and circulating medium, and compared with standard static in vitro immersion and with in vivo rat aorta models. In ex vivo and in vivo conditions, pure Mg wires were exposed to the aortic lumen and inserted into the aortic wall to mimic early- and long-term implantation, respectively...
December 21, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27993752/clinical-outcomes-of-bioresorbable-versus-durable-polymer-coated-everolimus-eluting-stents-in-real-world-complex-patients
#11
Marco G Mennuni, Giulio G Stefanini, Paolo A Pagnotta, Elton Pllaha, Marco Araco, Omar A Meelu, Federica Turati, Bernhard Reimers, Gennaro Sardella, Patrizia Presbitero
AIMS: To evaluate the safety and efficacy profile of new-generation, Synergy-Everolimus Eluting stents (S-EES) as compared to Xience-EES (X-EES) with durable polymer-coating in "complex patients". METHODS AND RESULTS: We included 2,001 consecutive patients treated with S-EES (n=400) or X- EES (n=1601) at two Italian centers between May 2013 and May 2015. We used propensity-score matching to obtain two cohorts of patients with similar baseline risk profiles. Patients were stratified according to baseline complexity based on the EVOLVE-II trial exclusion criteria...
December 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27980542/antithrombotic-management-in-patients-with-percutaneous-coronary-intervention-requiring-oral-anticoagulation
#12
REVIEW
Jarosław Zalewski, Anetta Undas
The dynamic evolution of therapeutic options including the use of vitamin K antagonists (VKA), non-vitamin K oral anticoagulants (NOAC), more potent antiplatelet drugs as well as new generation drug-eluting stents could lead to the view that the current recommendations on the management of patients with percutaneous coronary intervention (PCI) requiring oral anticoagulation do not keep up with the results of several clinical studies published within the last 5 years. In the present overview, we summarize the recent advances in antithrombotic management used in atrial fibrillation patients undergoing PCI for stable coronary artery disease or acute coronary syndrome (ACS)...
2016: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/27976797/comparable-vascular-response-of-a-new-generation-sirolimus-eluting-stents-when-compared-to-fluoropolymer-everolimus-eluting-stents-in-the-porcine-coronary-restenosis-model
#13
Piotr P Buszman, Magdalena J Michalak, Maciej Pruski, Carlos Fernandez, Michał Jelonek, Adam Janas, Claudine Savard, Beata Gwiazdowska-Nowotka, Aleksander Żurakowski, Wojciech Wojakowski, Paweł E Buszman, Krzysztof Milewski
BACKGROUND: Novel sirolimus eluting stents (SES) have shown non-inferior clinical outcomes when compared to everolimus eluting stents (EES), however only limited preclinical data have been published. Therefore, we evaluate vascular response of a new generation biodegradable polymer SES (BP-SES: Alex Plus, Balton) and fluoropolymer EES (EES: Xience Pro, Abbott) in the porcine coronary restenosis model. METHODS: A total of 40 stents were implanted with 120% overstretch in coronaries of 17 domestic swine: 16 BP-SES, 16 EES and 8 bare metal controls (BMS)...
2016: Cardiology Journal
https://www.readbyqxmd.com/read/27970228/tct-837-comparable-vascular-response-of-a-new-generation-sirolimus-eluting-stents-when-compared-to-fluoropolymer-everolimus-eluting-stents-in-the-porcine-coronary-restenosis-model
#14
Piotr Buszman, Magdalena Michalak, Maciej Pruski, Michał Jelonek, Adam Janas, Aleksander Żurakowski, Beata Gwiazdowska-Nowotka, Wojtek Wojakowski, Paweł Buszman, Krzysztof Milewski
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970196/tct-807-an-optical-coherence-tomography-assessment-of-new-generation-mesh-covered-stents-after-carotid-stenting
#15
Tomoyuki Umemoto, Gianmarco de Donato, Andrea Pacchioni, Alessandro Sciahbasi, Giuseppe Ferrante, Mitsuaki Isobe, Carlo Setacci
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969932/tct-564-effect-of-intravascular-ultrasound-guided-vs-angiography-guided-new-generation-drug-eluting-stent-implantation-meta-analysis-with-individual-patient-level-data-from-2-345-randomized-patients
#16
Dong-Ho Shin, Sung-Jin Hong, Gary Mintz, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Yangsoo Jang, Myeong-Ki Hong
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969834/tct-475-effect-of-stent-diameter-in-women-undergoing-percutaneous-coronary-intervention-with-early-and-new-generation-drug-eluting-stents-from-the-women-in-innovation-and-drug-eluting-stents-win-des-collaboration
#17
Gennaro Giustino, Camilla Melegari, Usman Baber, Samantha Sartori, Gregg Stone, Martin Leon, Takeshi Kimura, Melissa Aquino, Serdar Farhan, George Danias, Giulio Stefanini, Stephan Windecker, Philippe Gabriel Steg, Raban Jeger, Marco Valgimigli, Adnan Kastrati, Alaide Chieffo, Roxana Mehran
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969826/tct-471-impact-of-new-versus-early-generation-drug-eluting-stents-in-women-according-to-age-from-the-women-in-innovation-and-drug-eluting-stents-win-des-collaboration
#18
Birgit Vogel, Usman Baber, Gennaro Giustino, Samantha Sartori, Gregg Stone, Stephan Windecker, Patrick Serruys, Edoardo Camenzind, Pieter Smits, David Kandzari, George Dangas, Jaya Chandrasekhar, Michela Faggioni, Serdar Farhan, Raban Jeger, Takeshi Kimura, Ghada Mikhail, Rebecca Ortega, Marco Valgimigli, Adnan Kastrati, Roxana Mehran
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969629/tct-288-safety-and-efficacy-of-new-generation-drug-eluting-stents-in-women-undergoing-complex-percutaneous-coronary-intervention-from-the-women-in-innovation-and-drug-eluting-stents-win-des-collaborative-patient-level-pooled-analysis
#19
Gennaro Giustino, Usman Baber, Philippe Généreux, Gregg Stone, Martin Leon, George Dangas, Samantha Sartori, Melissa Aquino, Stephan Windecker, Patrick Serruys, Adnan Kastrati, William Wijns, Philippe Gabriel Steg, Giulio Stefanini, Marco Valgimigli, Takeshi Kimura, Clemens von Birgelen, Edoardo Camenzind, Soeren Galatius, Roxana Mehran
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27923461/impact-of-patient-and-lesion-complexity-on-long-term-outcomes-following-coronary-revascularization-with-new-generation-drug-eluting-stents
#20
Konstantinos C Koskinas, Masanori Taniwaki, Fabio Rigamonti, Dik Heg, Marco Roffi, David Tüller, Olivier Muller, Andre Vuillomenet, Stephane Cook, Daniel Weilenmann, Christopher Kaiser, Peiman Jamshidi, Peter Jüni, Stephan Windecker, Thomas Pilgrim
Long-term clinical outcomes of new-generation drug-eluting stents in complex anatomic and clinical settings are not well defined. This study assessed the impact of patient and lesion complexity on 2-year outcomes after coronary revascularization with ultrathin strut biodegradable-polymer (BP) sirolimus-eluting stents (SES) versus durable-polymer (DP) everolimus-eluting stents (EES). In a prespecified analysis of the BIOSCIENCE randomized trial (NCT01443104), complex patients (911 of 2,119; 43%) were defined by the presence of acute ST-elevation myocardial infarction (MI); left ventricular ejection fraction ≤30%; renal dysfunction; insulin-treated diabetes; treatment of ostial lesion, bypass graft, unprotected left main lesion; or 3-vessel intervention...
November 16, 2016: American Journal of Cardiology
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