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https://www.readbyqxmd.com/read/29435779/therapeutic-options-for-in-stent-restenosis
#1
REVIEW
Charles Nicolais, Vladimir Lakhter, Hafeez Ul Hassan Virk, Partha Sardar, Chirag Bavishi, Brian O'Murchu, Saurav Chatterjee
PURPOSE OF REVIEW: In-stent restenosis (ISR) is a complex disease process that became apparent shortly after the introduction of stents into clinical practice. This review seeks to define in-stent restenosis (ISR) as well as to summarize the major treatment options that have been developed and studied over the past two decades. RECENT FINDINGS: Recent developments in drug-coated balloons and bioresorbable vascular scaffolds have added new potential treatments for ISR...
February 12, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29432400/treatment-of-coronary-artery-disease-with-a-new-generation-drug-coated-balloon-final-results-of-the-italian-elutax-sv-registry-dcb-rise
#2
Bernardo Cortese, Fabrizio D'Ascenzo, Raffaela Fetiveau, Vruyr Balian, Simonetta Blengino, Massimo Fineschi, Renata Rogacka, Corrado Lettieri, Andrea Pavei, Maurizio D'Amico, Arnaldo Poli, Gaetano Di Palma, Roberto A Latini, Pedro S Orrego, Romano Seregni
AIMS: Drug-coated balloons (DCBs) are a recognized alternative to stents for the treatment of in-stent restenosis (ISR), and there is some initial clinical evidence about their efficacy for the treatment of small coronary vessels. Newer-generation DCBs were developed to overcome the reduced deliverability of the previous generation, also warranting a more effective drug delivery to vessel wall. However, the vast majority of new-generation DCBs still lack of reliability due to paucity of clinical data...
February 9, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29407134/effectiveness-of-new-generation-drug-eluting-stents-in-ostial-right-coronary-artery-lesions
#3
EDITORIAL
Matteo De Rosa, Gaetano Santulli
No abstract text is available yet for this article.
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29407132/comparison-of-mid-term-clinical-outcomes-after-treatment-of-ostial-right-coronary-artery-lesions-with-early-and-new-generation-drug-eluting-stents-insights-from-an-international-multicenter-registry
#4
Satoru Mitomo, Richard J Jabbour, Yusuke Watanabe, Antonio Mangieri, Marco Ancona, Damiano Regazzoli, Akihito Tanaka, Akihiro Nakajima, Toru Naganuma, Francesco Giannini, Azeem Latib, Sunao Nakamura, Antonio Colombo
BACKGROUND: There are only a limited number of studies comparing clinical outcomes after treatment of right coronary artery (RCA) aorto-ostial (AO) lesions with early (E-) and new (N-) generation drug-eluting stents (DES). METHODS: From January 2005 to December 2013, 334 de novo RCA AO lesions treated with DES (E-:142 lesions, N-:192 lesions) at 2 high-volume centers (Italy and Japan) were included in this study. The primary endpoint was target lesion failure (TLF) defined as composite of cardiac mortality, target vessel myocardial infarction, and target lesion revascularization (TLR)...
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29405596/hybrid-coronary-revascularization-time-for-a-new-comparator
#5
EDITORIAL
Naoki Misumida, David J Moliterno
The present meta-analysis found no significant difference between hybrid coronary revascularization (HCR) and bypass surgery (CABG) regarding intermediate-term major adverse cardiac and cerebrovascular events. HCR is feasible, historically with higher revascularization rates but less perioperative morbidity With a comparable frequency of repeat revascularization between current-generation drug-eluting stents and CABG, future trials of HCR are considering multi-vessel PCI as the new comparator.
February 1, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29396239/long-term-outcomes-of-new-generation-drug-eluting-stents-versus-coronary-artery-bypass-grafting-for-multivessel-and-or-left-main-coronary-artery-disease-a-bayesian-network-meta-analysis-of-randomized-controlled-trials
#6
George S Mina, Hussam Watti, Demiana Soliman, Anand Shewale, Jessica Atkins, Pratap Reddy, Paari Dominic
BACKGROUND: Most data guiding revascularization of multivessel disease (MVD) and/or left main disease (LMD) favor coronary artery bypass grafting (CABG) over percutaneous coronary intervention (PCI). However, those data are based on trials comparing CABG to bare metal stents (BMS) or old generation drug eluting stents (OG-DES). Hence, it is essential to outcomes of CABG to those of new generation drug eluting stents (NG-DES). METHODS: We searched PUBMED and Cochrane database for trials evaluating revascularization of MVD and/or LMD with CABG and/or PCI...
January 5, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29387935/-picosecond-infrared-laser-fiber-assisted-sclerostomy-pirl-fast-a%C3%A2-first-proof-of-principle-analysis
#7
J Mehlan, S Uschold, N O Hansen, T Gosau, D Eggert, M Spitzer, H Petersen, S J Linke, R J Dwayne Miller
INTRODUCTION: The aim of this study was an analysis of the feasibility of a picosecond infrared laser fiber-assisted sclerostomy (PIRL-FAST) using a novel sapphire fiber and different energy levels of the picosecond laser. METHOD: The laser-assisted sclerostomy was carried out with a newly generated sapphire fiber of the PIRL-HP2-1064 OPA-3000 (Attodyne, Canada). Immediately after the intervention, the eyes were fixed in phosphate-buffered 3.5% formaldehyde. For subsequent histological analysis the eyes were cut into 4 μm thick sections and stained with hematoxylin and eosin (H&E, Merck, Darmstadt, Germany)...
January 31, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29376002/a-feasibility-study-of-using-biodegradable-magnesium-alloy-in-glaucoma-drainage-device
#8
REVIEW
Xiang-Ji Li, Lin Xie, Fu-Sheng Pan, Yong Wang, Hong Liu, Yu-Rong Tang, Cindy Ml Hutnik
Technological advances in glaucoma have challenged the traditional treatment paradigm. Historically incisional surgery has been used in cases of advanced disease and/or uncontrolled intraocular pressures resistant to medical or laser interventions. More recently, perhaps due to advancements in imaging, surgery has been suggested to be beneficial earlier in the treatment paradigm. Despite these trends, surgical manipulation of the tissues and unpredictability of wound healing continue to result in surgical failure...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29369807/the-degradation-and-transport-mechanism-of-a-mg-nd-zn-zr-stent-in-rabbit-common-carotid-artery-a-20-month-study
#9
Jian Zhang, Haiyan Li, Wu Wang, Hua Huang, Jia Pei, Haiyun Qu, Guangyin Yuan, Yongdong Li
Mg-based stent is a promising candidate of the next generation fully degradable vascular stents. The latest progress includes the CE approval of the Magmaris WE43 based drug eluting stent. However, so far, the long term (more than 1 year implantation) in vivo degradation and the physiological effects caused by the degradation products were still unclear. In this study, a 20 month observation was carried out after the bare Mg-Nd-Zn-Zr (abbr. JDBM) stent prototype was implanted into the common carotid artery of New Zealand white rabbit in order to evaluate its safety, efficacy and especially degradation behavior...
January 21, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29369375/safety-and-efficacy-of-second-generation-drug-eluting-stents-compared-with-bare-metal-stents-an-updated-meta-analysis-and-regression-of-9-randomized-clinical-trials
#10
REVIEW
Ahmed N Mahmoud, Nikhil H Shah, Islam Y Elgendy, Nayan Agarwal, Akram Y Elgendy, Amgad Mentias, Amr F Barakat, Dhruv Mahtta, R David Anderson, Anthony A Bavry
The efficacy of second-generation drug-eluting stents (DES; eg, everolimus and zotarolimus) compared with bare-metal stents (BMS) in patients undergoing percutaneous coronary intervention was challenged recently by new evidence from large clinical trials. Thus, we aimed to conduct an updated systematic review and meta-analysis of randomized clinical trials (RCTs) evaluating the efficacy and safety of second-generation DES compared with BMS. Electronic databases were systematically searched for all RCTs comparing second-generation DES with BMS and reporting clinical outcomes...
January 25, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29359390/dual-antiplatelet-therapy-after-coronary-drug-eluting-stent-implantation-in-china-a-large-single-center-study
#11
Jing-Jing Xu, Zhan Gao, Yin Zhang, Li-Jian Gao, Jue Chen, Shu-Bin Qiao, Run-Lin Gao, Yue-Jin Yang, Bo Xu, Jin-Qing Yuan
OBJECTIVE: To investigate the actual dual antiplatelet therapy (DAPT) duration after drug-eluting stent (DES) treatment in China. BACKGROUND: Currently, less is known about actual DAPT duration after drug-eluting stent (DES) treatment in China. Here, we performed a study in the largest cardiovascular center in China to investigate DAPT duration and identify associated factors after DES implantation. METHODS: A total of 9,919 consecutive patients with DES implantation from January 2013 to December 2013 were enrolled...
January 23, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29346562/scaffold-free-trachea-regeneration-by-tissue-engineering-with-bio-3d-printing
#12
Daisuke Taniguchi, Keitaro Matsumoto, Tomoshi Tsuchiya, Ryusuke Machino, Yosuke Takeoka, Abdelmotagaly Elgalad, Kiyofumi Gunge, Katsunori Takagi, Yasuaki Taura, Go Hatachi, Naoto Matsuo, Naoya Yamasaki, Koichi Nakayama, Takeshi Nagayasu
OBJECTIVES: Currently, most of the artificial airway organs still require scaffolds; however, such scaffolds exhibit several limitations. Alternatively, the use of an autologous artificial trachea without foreign materials and immunosuppressants may solve these issues and constitute a preferred tool. The rationale of this study was to develop a new scaffold-free approach for an artificial trachea using bio-3D printing technology. Here, we assessed the circumferential tracheal replacement using scaffold-free trachea-like grafts generated from isolated cells in an inbred animal model...
January 15, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29344373/multianalysis-with-optical-coherence-tomography-and-vasomotion-in-everolimus-eluting-stents-and-everolimus-eluting-biovascular-scaffolds-the-moves-trial
#13
Diego A Arroyo, Sara Schukraft, Zacharenia Kallinikou, Jean-Christophe Stauffer, Gérard Baeriswyl, Jean-Jacques Goy, Mario Togni, Stéphane Cook, Serban Puricel
Aims: To compare endothelium-dependent vasomotor function and vascular healing 15 months after implantation of two new-generation drug-eluting stents and biovascular scaffolds (BVS). Methods and results: A total of 28 patients previously treated with a SYNERGY stent (bioabsorbable polymer everolimus-eluting stents (BP-EES)), a PROMUS stent (persistent polymer everolimus-eluting stents (PP-EES)) or an ABSORB (BVS) underwent control coronary angiography, 15 months after implantation, coupled with optical coherence tomography imaging and supine bicycle exercise...
2018: Open Heart
https://www.readbyqxmd.com/read/29338862/new-generation-stents-compared-with-coronary-bypass-surgery-for-unprotected-left-main-disease-a-word-of-caution
#14
Umberto Benedetto, David P Taggart, Miguel Sousa-Uva, Giuseppe Biondi-Zoccai, Antonino Di Franco, Lucas B Ohmes, Mohamed Rahouma, Mohamed Kamel, Massimo Caputo, Leonard N Girardi, Gianni D Angelini, Mario Gaudino
BACKGROUND: With the advent of bare metal stents and drug-eluting stents, percutaneous coronary intervention has emerged as an alternative to coronary artery bypass grafting surgery for unprotected left main disease. However, whether the evolution of stents technology has translated into better results after percutaneous coronary intervention remains unclear. We aimed to compare coronary artery bypass grafting with stents of different generations for left main disease by performing a Bayesian network meta-analysis of available randomized controlled trials...
January 12, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29313029/translation-in-cardiovascular-stents-and-occluders-from-biostable-to-fully-degradable
#15
REVIEW
Yingying Huang, Yee Shan Wong, Herr Cheun Anthony Ng, Freddy Y C Boey, Subbu Venkatraman
Cardiovascular disease is a major cause of morbidity and mortality, especially in developed countries. Most academic research efforts in cardiovascular disease management focus on pharmacological interventions, or are concerned with discovering new disease markers for diagnosis and monitoring. Nonpharmacological interventions with therapeutic devices, conversely, are driven largely by novel materials and device design. Examples of such devices include coronary stents, heart valves, ventricular assist devices, and occluders for septal defects...
June 2017: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/29310720/direct-comparison-of-coronary-bare-metal-vs-drug-eluting-stents-same-platform-different-mechanics
#16
Wolfram Schmidt, Peter Lanzer, Peter Behrens, Christoph Brandt-Wunderlich, Alper Öner, Hüseyin Ince, Klaus-Peter Schmitz, Niels Grabow
BACKGROUND: Drug-eluting stents (DES) compared to bare metal stents (BMS) have shown superior clinical performance, but are considered less suitable in complex cases. Most studies do not distinguish between DES and BMS with respect to their mechanical performance. The objective was to obtain mechanical parameters for direct comparison of BMS and DES. METHODS: In vitro bench tests evaluated crimped stent profiles, crossability in stenosis models, elastic recoil, bending stiffness (crimped and expanded), and scaffolding properties...
January 8, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29301648/effect-of-increasing-stent-length-on-3-year-clinical-outcomes-in-women-undergoing-percutaneous-coronary-intervention-with-new-generation-drug-eluting-stents-patient-level-pooled-analysis-of-randomized-trials-from-the%C3%A2-win-des-initiative
#17
Jaya Chandrasekhar, Usman Baber, Samantha Sartori, Giulio G Stefanini, Michele Sarin, Birgit Vogel, Serdar Farhan, Edoardo Camenzind, Martin B Leon, Gregg W Stone, Patrick W Serruys, William Wijns, Philippe G Steg, Giora Weisz, Alaide Chieffo, Adnan Kastrati, Stephan Windecker, Marie-Claude Morice, Pieter C Smits, Clemens von Birgelen, Ghada W Mikhail, Dipti Itchhaporia, Laxmi Mehta, Hyo-Soo Kim, Marco Valgimigli, Raban V Jeger, Takeshi Kimura, Søren Galatius, David Kandzari, George Dangas, Roxana Mehran
OBJECTIVES: The aim of this study was to examine whether stent length per patient and stent length per lesion are negative markers for 3-year outcomes in women following percutaneous coronary intervention (PCI) with new-generation drug-eluting stents (DES). BACKGROUND: In the era of advanced stent technologies, whether stent length remains a correlate of adverse outcomes is unclear. METHODS: Women treated with new-generation DES in 14 randomized trials from the WIN-DES (Women in Innovation and Drug-Eluting Stents) pooled database were evaluated...
January 8, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29300853/vascular-response-to-percutaneous-coronary-intervention-with-biodegradable-polymer-vs-new-generation-durable-polymer-drug-eluting-stents-a-meta-analysis-of-optical-coherence-tomography-imaging-trials
#18
Salvatore Cassese, Erion Xhepa, Gjin Ndrepepa, Sebastian Kufner, Roisin Colleran, Daniele Giacoppo, Tobias Koppara, Nader Mankerious, Robert A Byrne, Karl-Ludwig Laugwitz, Heribert Schunkert, Massimiliano Fusaro, Adnan Kastrati, Michael Joner
Aims: Whether biodegradable-polymer drug-eluting stents (BP-DES) induce a vascular response at follow-up more favourable than that of new-generation durable-polymer drug-eluting stents (DP-DES) remains controversial. We sought to evaluate the vascular response to percutaneous coronary intervention (PCI) with BP-DES vs. new-generation DP-DES as assessed by optical coherence tomography (OCT) imaging at follow-up. Methods and results: We undertook a meta-analysis of aggregate data by searching electronic scientific databases for investigations of PCI-patients receiving BP-DES vs...
January 2, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29297906/-treatment-of-acute-myocardial-infarction-in-2017
#19
Giovanni Cimmino, Davide D'Andrea, Ciro Mauro, Carmine Morisco, Plinio Cirillo
Acute myocardial infarction is a clinical cardiac emergency associated with potential and substantial morbidity and mortality. This disorder is triggered by an acute coronary syndrome caused by episodes of plaque ulceration, fissuration, or rupture with subsequent production of thrombogenic material and intravascular thrombus formation. The presence or absence of ST-segment elevation on the ECG defines the two main clinical spectrum of ST-segment elevation or non-ST-segment elevation myocardial infarction. In the last three decades, pharmacological and interventional management as well as in-hospital care have dramatically improved...
December 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29283053/structural-and-design-evolution-of-bio-resorbable-scaffolds-the-journey-so-far
#20
Sundeep Mishra
BACKGROUND: Coronary stenting has now become a gold standard to prevent or counteract narrowing and blocking of vessels due to disease or injury. While the use of stents has been successful, they are not without drawbacks and concerns. Restenosis and stent thrombosis after an interventional procedure are the dreaded side effects resulting from the body's natural response to a foreign object in the vasculature. New developments in drug-eluting stents, such as biodegradable materials could mitigate some of the problems like stent thrombosis at least late stent thrombosis...
December 27, 2017: Current Pharmaceutical Design
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