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https://www.readbyqxmd.com/read/29667015/stent-thrombosis-rates-the-first-year-and-beyond-with-new-and-old-generation-drug-eluting-stents-compared-to-bare-metal-stents
#1
Christoph Varenhorst, Martin Lindholm, Giovanna Sarno, Göran Olivecrona, Ulf Jensen, Johan Nilsson, Jörg Carlsson, Stefan James, Bo Lagerqvist
OBJECTIVES: Old-generation drug-eluting coronary stents (o-DES) have despite being safe and effective been associated with an increased propensity of late stent thrombosis (ST). We evaluated ST rates in o-DES, new-generation DES (n-DES) and bare metal stents (BMS) the first year (< 1 year) and beyond 1 year (> 1 year). METHODS: We evaluated all implantations with BMS, o-DES (Cordis Cypher, Boston Scientific Taxus Liberté and Medtronic Endeavor) and n-DES in the Swedish coronary angiography and angioplasty registry (SCAAR) between 1 January 2007 and 8 January 2014 (n = 207 291)...
April 17, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29661004/percutaneous-versus-surgical-revascularization-for-left-main-or-multivessel-coronary-artery-disease-results-from-a-large-scale-meta-analysis-in-the-era-of-drug-eluting-stents
#2
Monica Verdoia, Lucia Barbieri, Elvin Kedhi, Harry Suryapranata, Giuseppe De Luca
The best treatment options for left main (LM) or multivessel coronary disease (MVD) are still debated. We performed a meta-analysis of randomized trials comparing percutaneous versus surgical revascularization for LM or MVD. Primary end point was overall mortality. Secondary end points were major adverse cardiovascular events, recurrent myocardial infarction, repeated revascularization, or stroke. A total of 8 randomized trials were included, involving 8694 patients, 50% undergoing percutaneous coronary intervention (PCI)...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29657254/are-all-new-generation-drug-eluting-stents-equal-long-term-follow-up-is-necessary
#3
Kengo Tanabe
No abstract text is available yet for this article.
April 13, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29656280/real-world-bioresorbable-vascular-scaffold-experience-compared-with-second-generation-metallic-drug-eluting-stents-in-complex-coronary-lesions
#4
Naotaka Okamoto, Hiroshi Ueda, Takahiro Yoshimura, Surbhi Chamaria, Samit Bhatheja, Yuliya Vengrenyuk, Samaneh Rabiei, Yonandy Barrientos, Vishal Kapur, Nitin Barman, Joseph Sweeny, Usman Baber, Roxana Mehran, Samin K Sharma, Annapoorna S Kini
OBJECTIVES: The aim of the study was to compare the acute outcomes of Absorb bioresorbable vascular scaffolds (BVS) and second-generation drug-eluting stent (DES) implantation in routine clinical practice. There is a paucity of data regarding BVS use in a real-world patient population. METHODS: The study population comprised 40 consecutive patients who underwent percutaneous coronary intervention (PCI) with BVS implantation at a tertiary-care center in New York, New York between July and December of 2016...
April 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29651802/three-months-optical-coherence-tomography-analysis-of-a-biodegradable-polymer-sirolimus-eluting-stent
#5
Еvgeny Kretov, Ivan Naryshkin, Vitaly Baystrukov, Igor Grazhdankin, Aleksei Prokhorikhin, Dmitry Zubarev, Alexey Biryukov, Vladimir Verin, Andrey Boykov, Dastan Malaev, Evgeny Pokushalov, Alexander Romanov, Martin W Bergmann
OBJECTIVE: We aimed to assess early neointimal healing by optical coherence tomography (OCT) 3 months after implantation of the ultrathin Orsiro® sirolimus-eluting stent with biodegradable polymer. BACKGROUND: New generations of drug-eluting stents with biodegradable polymer have been developed to avoid the continued vascular irritation of durable polymers. METHODS: In this prospective, open-label study, 34 patients received an Orsiro® sirolimus-eluting stent with biodegradable polymer...
April 12, 2018: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29618159/early-p2y12-inhibitors-escalation-in-primary-pci-patients-insights-from-the-renovami-registry
#6
Alessandro Lupi, Roberta Della Bona, Emanuele Meliga, Davide Capodanno, Alon Schaffer, Angelo S Bongo, Giovanni Gaudio, Luigina Guasti, Dimitrios Alexopoulos, Marco Valgimigli, Italo Porto
BACKGROUND:  Early escalation from clopidogrel to new generation P2Y12 inhibitors is common practice in patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). Real-world data about this strategy, however, are limited. METHODS:  From 2012 to 2015, 1,057 consecutive STEMI patients treated with pPCI in an Italian hub-and-spoke network were prospectively included in an observational registry (RENOVAMI, ClinicalTrials...
April 4, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29589672/the-synergy-stent-in-high-bleeding-risk-patients-why-design-matters
#7
Mauro Chiarito, Davide Cao, Francesco Cannata, Cristina Panico, Bernhard Reimers, Giulio G Stefanini
Antithrombotic management after percutaneous coronary intervention is based on dual antiplatelet therapy (DAPT), that has unequivocally shown to reduce the risk of recurrent ischemic events at cost of an important risk of bleeding. In order to balance ischemic and bleeding risks, DAPT duration should be based on patients and lesions features as well as stent type. Based on these considerations, patients at high bleeding risk (HBR) undergoing PCI represent a challenging subgroup. The Synergy stent (Boston Scientific, Marlborough, MA, USA) is a new-generation everolimus-eluting stent with a biodegradable polymer coating, presenting several features that have the potential to reduce acute and long-term thrombogenicity and the subsequent need for DAPT...
March 28, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29578470/development-of-asymmetric-stent-for-treatment-of-eccentric-plaque
#8
Achmad Syaifudin, Ryo Takeda, Katsuhiko Sasaki
The selection of stent and balloon type is decisive in the stenting process. In the treatment of an eccentric plaque obstruction, a symmetric expansion from stent dilatation generates nonuniform stress distribution, which may aggravate fibrous cap prone to rupture. This paper developed a new stent design to treat eccentric plaque using structural transient dynamic analysis in ANSYS. A non-symmetric structural geometry of stent is generated to obtain reasonable stress distribution safe for the arterial layer surrounding the stent...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29573134/magnetoelastic-galfenol-as-a-stent-material-for-wirelessly-controlled-degradation-rates
#9
Andrew DeRouin, Roger Guillory, Weilue He, Megan Frost, Jeremy Goldman, Keat Ghee Ong
The gold standard of care for coronary artery disease, a leading cause of death for in the world, is balloon angioplasty in conjunction with stent deployment. However, implantation injuries and long-term presence of foreign material often promotes significant luminal tissue growth, leading to a narrowing of the artery and severely restricted blood flow. A promising method to mitigate this process is the use of biodegradable metallic stents, but thus far they have either degraded too slowly (iron) or disappeared prematurely (magnesium)...
March 23, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29567650/the-new-low-profile-web-17-system-for-treatment-of-intracranial-aneurysms-first-clinical-experiences
#10
S B T van Rooij, J P Peluso, M Sluzewski, H G Kortman, W J van Rooij
BACKGROUND AND PURPOSE: The Woven EndoBridge (WEB) is an intrasaccular flow diverter intended to treat wide-neck aneurysms. The latest generation WEBs needed a 0.021-inch microcatheter in the small sizes. Recently, a lower profile range of WEBs compliant with a 0.017-inch microcatheter (WEB 17) has been introduced. We present the first clinical results of treatment of both ruptured and unruptured aneurysms with the WEB 17. MATERIALS AND METHODS: Between December 2016 and September 2017, forty-six aneurysms in 40 patients were treated with the WEB 17...
March 22, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29556525/mobilization-of-progenitor-cells-and-assessment-of-vessel-healing-after-second-generation-drug-eluting-stenting-by-optical-coherence-tomography
#11
Masashi Sakuma, Takahisa Nasuno, Shichiro Abe, Syotaro Obi, Shigeru Toyoda, Isao Taguchi, Ryoichi Sohma, Ken-Ichi Inoue, Setsu Nishino, Koichi Node, Guiherme Attizzani, Hiram Bezerra, Marco Costa, Daniel Simon, Teruo Inoue
Background: Bone marrow-derived progenitor cells likely contribute to both endothelial- and smooth muscle cell-dependent healing responses in stent-injured vessel sites. This study aimed to assess mobilization of progenitor cells and vessel healing after zotarolimus-eluting (ZES) and everolimus-eluting (EES) stents. Methods and results: In 63 patients undergoing coronary stent implantation, we measured circulating CD34 + CD133 + CD45low cells and serum levels of biomarkers relevant to stem cell mobilization...
March 2018: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/29556153/longitudinal-deformation-of-distal-edge-in-a-new-generation-stent-caused-by-guidewire-entrapment
#12
Adam Taleb, Gaurav Parikh, Nikolaos Kakouros
Longitudinal stent deformation, described in some older stent geometries, prompted design modifications such as reinforcing struts on the proximal end. However, distal edges of stents-also subject to longitudinal force-have not been reinforced. We report a case of guidewire entrapment that deformed the distal edge of a new-generation stent during percutaneous coronary intervention, and we describe our efforts to restore the stent to its initial length. This case highlights the risk of manipulating equipment beyond the position of a newly deployed stent, the ongoing potential for deformation of distal edges in newer stent platforms, and the advisability of treating distal lesions before proximal ones...
February 2018: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/29537375/outcomes-of-patients-treated-with-ultrathin-strut-biodegradable-polymer-sirolimus-eluting-stents-versus-fluoropolymer-based-everolimus-eluting-stents-a-meta-analysis-of-randomized-trials
#13
Salvatore Cassese, Gjin Ndrepepa, Robert A Byrne, Sebastian Kufner, Anna Lena Lahmann, Nader Mankerious, Erion Xhepa, Karl-Ludwig Laugwitz, Heribert Schunkert, Massimiliano Fusaro, Adnan Kastrati, Michael Joner
AIMS: The ultrathin strut biodegradable-polymer sirolimus-eluting stent (SES) is a new-generation drug-eluting stent (DES) developed to improve the percutaneous treatment of patients with coronary artery disease. Here, we sought to investigate whether the performance of ultrathin strut biodegradable-polymer SES is superior to that of the benchmark thin-strut fluoropolymer-based everolimus-eluting stent (EES). METHODS AND RESULTS: We undertook a study-level meta-analysis of trials, in which patients receiving percutaneous coronary intervention (PCI) were randomly assigned to either SES or EES...
March 13, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29535893/temporal-changes-in-care-processes-and-outcomes-for-endovascular-treatment-of-acute-ischemic-stroke-retrospective-registry-data-from-three-korean-centers
#14
Jin Soo Lee, Seong-Joon Lee, Ji Man Hong, Jin Wook Choi, Jeong-Ho Hong, Hyuk-Won Chang, Chang-Hyun Kim, Yong-Won Kim, Dong-Hun Kang, Yong-Sun Kim, Bruce Ovbiagele, Andrew M Demchuk, Yang-Ha Hwang, Sung-Il Sohn
Background and Purpose: The purpose of the current study is to evaluate the influence of temporal patterns related to the availability of new endovascular treatment (EVT) devices on care processes and outcomes among patients with AIS. Materials and Methods: We enrolled 720 consecutive patients (January 2011 to May 2016) in a retrospective registry, ASIAN KR, from three Korean hospitals, who received EVT for acute ischemic stroke (AIS) caused by cervicocephalic arterial occlusions...
March 2018: Neurointervention
https://www.readbyqxmd.com/read/29483397/drug-eluting-balloon-versus-new-generation-drug-eluting-stent-for-the-treatment-of-in-stent-restenosis-an-updated-systematic-review-and-meta-analysis
#15
Kong-Yong Cui, Shu-Zheng Lyu, Min Zhang, Xian-Tao Song, Fei Yuan, Feng Xu
Background: Currently, drug-eluting balloon (DEB) appears to be an attractive alternative option for the treatment of in-stent restenosis (ISR). Nevertheless, the clinical outcomes of DEB have seldom been compared to those of new-generation drug-eluting stent (DES). Thus, this meta-analysis aimed to evaluate the safety and efficacy of DEB compared to those of new-generation DES in the treatment of ISR. Methods: A comprehensive search of electronic databases including PubMed, EMBASE, and Cochrane Library up to November 2, 2017 was performed to identify pertinent articles comparing DEB to new-generation DES for the treatment of ISR...
March 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29481718/long-term-efficacy-of-drug-coated-balloons-compared-with-new-generation-drug-eluting-stents-for-the-treatment-of-de-novo-coronary-artery-lesions
#16
Dimitrios Venetsanos, Sofia Sederholm Lawesson, Georgios Panayi, Tim Tödt, Ulf Berglund, Eva Swahn, Joakim Alfredsson
BACKGROUND: Studies comparing drug coated balloons (DCB) with new generation drug-eluting stents (nDES) for the treatment of de novo coronary artery lesions are lacking. METHODS: From 2009 to 2016, DCB or nDES used for treatment of de novo coronary lesions at our institution were included, in total 1,197 DEB and 6,458 nDES. We evaluated target lesions restenosis (TLR) and definite target lesion thrombosis (TLT). Propensity score modeling were utilized to study adjusted associations between treatment and outcomes...
February 26, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29481624/long-term-outcomes-using-the-stentless-livanova-sorin-pericarbon-freedom%C3%A2-valve-after-aortic-valve-replacement
#17
Guglielmo Stefanelli, Fabrizio Pirro, Alina Olaru, Giuseppe Danniballe, Clorinda Labia, Luca Weltert
OBJECTIVES: Information on the long-term safety, efficacy and durability of third-generation stentless aortic valves is lacking. METHODS: In this single-centre, single-surgeon retrospective observational study, between 2003 and 2015, consecutive, non-selected aortic valve replacement (AVR) patients were implanted with the LivaNova-Sorin Pericarbon Freedom™, a third-generation stentless aortic xenograft. Changes in clinical and echocardiographic parameters were examined, as were mortality, structural valve deterioration and reoperation, according to age at 5, 10 and 14 years...
February 21, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29472254/comparison-of-new-generation-drug-eluting-stents-versus-drug-coated-balloon-for-in-stent-restenosis-a-meta-analysis-of-randomised-controlled-trials
#18
Jin-Zan Cai, Yong-Xiang Zhu, Xin-Yu Wang, Christos V Bourantas, Javaid Iqbal, Hao Zhu, Paul Cummins, Sheng-Jie Dong, Anthony Mathur, Yao-Jun Zhang
OBJECTIVE: The study sought to compare angiographic and clinical outcomes of new-generation drug-eluting stents (DES) versus drug-coated balloon (DCB) in patients with coronary in-stent restenosis (ISR). DESIGN: Meta-analysis using data from randomised trial found by searches on PubMed, the Cochrane Library, ClinicalTrials.gov and websites of major cardiovascular congresses. SETTING: Only randomised trials comparing DES with DCB were included...
February 22, 2018: BMJ Open
https://www.readbyqxmd.com/read/29471933/safety-and-effectiveness-of-second-generation-drug-eluting-stents-in-patients-with-left-main-coronary-artery-disease
#19
Pil Hyung Lee, Osung Kwon, Jung-Min Ahn, Cheol Hyun Lee, Do-Yoon Kang, Jung-Bok Lee, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Duk-Woo Park, Seung-Jung Park
BACKGROUND: Limited data are available on the relative performances between different types of drug-eluting stents (DES) for obstructive left main coronary artery disease (LMCAD). OBJECTIVES: This study sought to compare effectiveness and safety profiles of various second-generation DES for LMCAD in real-world clinical practice. METHODS: Among 4,470 patients in 3, multicenter, prospective registries (IRIS-DES [Interventional Cardiology Research Incorporation Society-Drug-Eluting Stents] registry, the IRIS-MAIN [Interventional Cardiology Research Incorporation Society-Left MAIN Revascularization] registry, and the PRECOMBAT [PREmier of Randomized COMparison of Bypass Surgery versus AngioplasTy Using Drug-Eluting Stent in Patients with Left Main Coronary Artery Disease] study) treated between July 2007 and July 2015, the authors identified 2,692 patients with significant LMCAD who received second-generation DES; 1,254 with cobalt-chromium everolimus-eluting stents (CoCr-EES), 232 with biodegradable polymer biolimus-eluting stents (BP-BES), 616 with platinum-chromium EES (PtCr-EES), and 590 with Resolute zotarolimus-eluting stent (Re-ZES)...
February 27, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29468288/efficacy-of-mechanical-thrombectomy-using-stent-retriever-and-balloon-guiding-catheter
#20
S Kammerer, R du Mesnil de Rochemont, M Wagner, S -J You, S Tritt, M Mueller-Eschner, F C Keil, A Lauer, J Berkefeld
PURPOSE: Intra-arterial therapy of acute ischemic stroke has developed rapidly in recent years. Due to proven efficacy in randomized trials, stent retrievers were replacing first-generation thrombectomy devices and have been defined as method of choice. However, aspiration catheters or a combination of several techniques have shown promising rates of successful recanalizations. To create a basis for comparison of the new approaches according to real-world data, we determined the first pass recanalization rate of an evidence-based standard technique with the use of a stent retriever in combination with a balloon-guiding catheter...
May 2018: Cardiovascular and Interventional Radiology
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