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https://www.readbyqxmd.com/read/27923176/co-distribution-of-cysteine-cathepsins-and-matrix-metalloproteases-in-human-dentin
#1
Polliana Mendes Candia Scaffa, Lorenzo Breschi, Annalisa Mazzoni, Cristina de Mattos Pimenta Vidal, Rosa Curci, Fabianni Apolonio, Pietro Gobbi, David Pashley, Leo Tjäderhane, Ivarne Luis Dos Santos Tersariol, Fábio Dupart Nascimento, Marcela Rocha Carrilho
It has been hypothesized that cysteine cathepsins (CTs) along with matrix metalloproteases (MMPs) may work in conjunction in the proteolysis of mature dentin matrix. The aim of this study was to verify simultaneously the distribution and presence of cathepsins B (CT-B) and K (CT-K) in partially demineralized dentin; and further to evaluate the activity of CTs and MMPs in the same tissue. The distribution of CT-B and CT-K in sound human dentin was assessed by immunohistochemistry. A double-immunolabeling technique was used to identify, at once, the occurrence of those enzymes in dentin...
November 21, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27923149/the-effect-of-cerebral-asymmetries-and-eye-scanning-on-pseudoneglect-for-a-visual-search-task
#2
Michael E R Nicholls, Amelia Hobson, Joanne Petty, Owen Churches, Nicole A Thomas
Pseudoneglect is the tendency for the general population to over-attend to the left. While pseudoneglect is classically demonstrated using line bisection, it also occurs for visual search. The current study explored the influence of eye movements and functional cerebral asymmetry on asymmetries for visual search. In Experiment 1, 24 participants carried out a conjunction search for a target within a rectangular array. A leftward advantage for detecting targets was observed when the eyes were free to move, but not when they were restricted by short exposure durations...
December 3, 2016: Brain and Cognition
https://www.readbyqxmd.com/read/27923064/sparse-regression-based-structure-learning-of-stochastic-reaction-networks-from-single-cell-snapshot-time-series
#3
Anna Klimovskaia, Stefan Ganscha, Manfred Claassen
Stochastic chemical reaction networks constitute a model class to quantitatively describe dynamics and cell-to-cell variability in biological systems. The topology of these networks typically is only partially characterized due to experimental limitations. Current approaches for refining network topology are based on the explicit enumeration of alternative topologies and are therefore restricted to small problem instances with almost complete knowledge. We propose the reactionet lasso, a computational procedure that derives a stepwise sparse regression approach on the basis of the Chemical Master Equation, enabling large-scale structure learning for reaction networks by implicitly accounting for billions of topology variants...
December 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27922579/srs-22r-scores-in-non-operated-adolescent-idiopathic-scoliosis-patients-with-curves-greater-than-forty-degrees
#4
W Timothy Ward, Nicole A Friel, Tanya S Kenkre, Maria M Brooks, Joanne A Londino, James W Roach
STUDY DESIGN: Case control comparative series OBJECTIVE.: Describe surgical range adolescent idiopathic scoliosis (AIS) patients electing to forgo surgery and compare health related quality of life outcomes to a similar cohort of operated AIS patients by the same single surgeon. SUMMARY OF BACKGROUND DATA: No data have been published either documenting SRS-22r scores of non-operated patients with curves ≥ 40° or comparing these scores to a demographically similar operated cohort...
December 2, 2016: Spine
https://www.readbyqxmd.com/read/27922502/the-limb-girdle-muscular-dystrophies-and-the-dystrophinopathies
#5
Stanley Jones P Iyadurai, John T Kissel
PURPOSE OF REVIEW: The classic approach to identifying and accurately diagnosing limb-girdle muscular dystrophies (LGMDs) relied heavily on phenotypic characterization and ancillary studies including muscle biopsy. Because of rapid advances in genetic sequencing methodologies, several additional LGMDs have been molecularly characterized, and the diagnostic approach to these disorders has been simplified. This article summarizes the epidemiology, clinical features, and genetic defects underlying the LGMDs...
December 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27922026/percutaneous-gastrostomy-device-for-the-treatment-of-class-ii-and-class-iii-obesity-results-of-a-randomized-controlled-trial
#6
Christopher C Thompson, Barham K Abu Dayyeh, Robert Kushner, Shelby Sullivan, Alan B Schorr, Anastassia Amaro, Caroline M Apovian, Terrence Fullum, Amir Zarrinpar, Michael D Jensen, Adam C Stein, Steven Edmundowicz, Michel Kahaleh, Marvin Ryou, J Matthew Bohning, Gregory Ginsberg, Christopher Huang, Daniel D Tran, Joseph P Glaser, John A Martin, David L Jaffe, Francis A Farraye, Samuel B Ho, Nitin Kumar, Donna Harakal, Meredith Young, Catherine E Thomas, Alpana P Shukla, Michele B Ryan, Miki Haas, Heidi Goldsmith, Jennifer McCrea, Louis J Aronne
OBJECTIVES: The AspireAssist System (AspireAssist) is an endoscopic weight loss device that is comprised of an endoscopically placed percutaneous gastrostomy tube and an external device to facilitate drainage of about 30% of the calories consumed in a meal, in conjunction with lifestyle (diet and exercise) counseling. METHODS: In this 52-week clinical trial, 207 participants with a body-mass index (BMI) of 35.0-55.0 kg/m(2) were randomly assigned in a 2:1 ratio to treatment with AspireAssist plus Lifestyle Counseling (n=137; mean BMI was 42...
December 6, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27920861/colon-cancer-metastasis-to-the-sternum-palliative-treatment-with-radiofrequency-ablation-and-cement-injection
#7
Bryan E Wessel, Douglas Coldwell
Colon cancer metastasis to bone is extremely rare and has devastating consequences on patients' quality of life. Furthermore, radiofrequency ablation in conjunction with cementoplasty to nonweight bearing, flat bones has not been widely reported as palliative treatment for pain as a result of bone metastasis. Here, we present a case of a 47-year-old man who developed a sternal metastasis from an invasive adenocarcinoma of the colon originally diagnosed several years prior. The pain from the metastasis was originally treated with external beam radiation therapy, but after 6 weeks of continuous pain, it was retreated using radiofrequency ablation in conjunction with cementoplasty...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27920777/physical-interaction-of-t-cells-with-dendritic-cells-is-not-required-for-the-immunomodulatory-effects-of-the-edible-mushroom-agaricus-subrufescens
#8
Ruud H P Wilbers, Lotte B Westerhof, Jan van de Velde, Geert Smant, Debbie R van Raaij, Anton S M Sonnenberg, Jaap Bakker, Arjen Schots
Mushrooms are well known for their immunomodulating capacities. However, little is known about how mushroom-stimulated dendritic cells (DCs) affect T cells. Therefore, we investigated the effect of mushroom compounds derived from seven edible mushroom species on DCs, their fate in DCs, and the effect of the mushroom-stimulated DCs on T cells. Each mushroom species stimulated DCs in a different manner as was revealed from the DC's cytokine response. Assessing DC maturation revealed that only one mushroom species, Agaricus subrufescens, induced complete DC maturation...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27920671/proceedings-of-the-fourth-annual-deep-brain-stimulation-think-tank-a-review-of-emerging-issues-and-technologies
#9
Wissam Deeb, James J Giordano, Peter J Rossi, Alon Y Mogilner, Aysegul Gunduz, Jack W Judy, Bryan T Klassen, Christopher R Butson, Craig Van Horne, Damiaan Deny, Darin D Dougherty, David Rowell, Greg A Gerhardt, Gwenn S Smith, Francisco A Ponce, Harrison C Walker, Helen M Bronte-Stewart, Helen S Mayberg, Howard J Chizeck, Jean-Philippe Langevin, Jens Volkmann, Jill L Ostrem, Jonathan B Shute, Joohi Jimenez-Shahed, Kelly D Foote, Aparna Wagle Shukla, Marvin A Rossi, Michael Oh, Michael Pourfar, Paul B Rosenberg, Peter A Silburn, Coralie de Hemptine, Philip A Starr, Timothy Denison, Umer Akbar, Warren M Grill, Michael S Okun
This paper provides an overview of current progress in the technological advances and the use of deep brain stimulation (DBS) to treat neurological and neuropsychiatric disorders, as presented by participants of the Fourth Annual DBS Think Tank, which was convened in March 2016 in conjunction with the Center for Movement Disorders and Neurorestoration at the University of Florida, Gainesveille FL, USA. The Think Tank discussions first focused on policy and advocacy in DBS research and clinical practice, formation of registries, and issues involving the use of DBS in the treatment of Tourette Syndrome...
2016: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/27920247/what-patients-complaints-and-praise-tell-the-health-practitioner-implications-for-health-care-quality-a-qualitative-research-study
#10
Katia Mattarozzi, Fiamma Sfrisi, Filippo Caniglia, Alessandra De Palma, Monica Martoni
OBJECTIVE: In order to identify which health care aspects play a role in patient satisfaction and quality of health care, the present study analyses a large number of instances of complaint and praise. DESIGN AND SETTING: One thousand two hundred and thirty-five instances of complaint and one thousand five hundred thirty-six of praise submitted from patients or other souces (i.e. a patient's family member or a legal representative) to a northern-Italian hospital were analysed...
December 4, 2016: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/27920089/world-endometriosis-society-consensus-on-the-classification-of-endometriosis
#11
Neil P Johnson, Lone Hummelshoj, G David Adamson, Jörg Keckstein, Hugh S Taylor, Mauricio S Abrao, Deborah Bush, Ludwig Kiesel, Rulla Tamimi, Kathy L Sharpe-Timms, Luk Rombauts, Linda C Giudice
STUDY QUESTION: What is the global consensus on the classification of endometriosis that considers the views of women with endometriosis? SUMMARY ANSWER: We have produced an international consensus statement on the classification of endometriosis through systematic appraisal of evidence and a consensus process that included representatives of national and international, medical and non-medical societies, patient organizations, and companies with an interest in endometriosis...
December 5, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27919923/clonality-increases-with-snow-depth-in-the-arctic-dwarf-shrub-empetrum-hermaphroditum
#12
Miriam J Bienau, R Lutz Eckstein, Annette Otte, Walter Durka
PREMISE OF THE STUDY: Vegetative reproduction and spread through clonal growth plays an important role in arctic-alpine ecosystems with short cool growing seasons. Local variation in winter snow accumulation leads to discrete habitat types that may provide divergent conditions for sexual and vegetative reproduction. Therefore, we studied variation in clonal structure of a dominant, evergreen, dwarf shrub (Empetrum nigrum s.l. with the two taxa E. nigrum L. s.s. and E. hermaphroditum Hagerup) along a snow cover gradient and compared clonal diversity and spatial genetic structure between habitats...
December 5, 2016: American Journal of Botany
https://www.readbyqxmd.com/read/27919605/not-all-patients-with-critical-limb-ischaemia-require-revascularisation
#13
T B Santema, R M Stoekenbroek, J van Loon, M J W Koelemay, D T Ubbink
OBJECTIVES: International guidelines recommend revascularisation as the preferred treatment for patients with critical limb ischaemia (CLI). Most contemporary research focuses on the outcome of invasive procedures for CLI, but little is known about the outcome of conservative management. Amputation free survival (AFS) and overall survival (OS) was investigated in patients with CLI who did or did not receive revascularisation, and characteristics associated with clinical outcomes were explored...
December 2, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27919557/trend-shifts-in-satellite-derived-vegetation-growth-in-central-eurasia-1982-2013
#14
Hao-Jie Xu, Xin-Ping Wang, Tai-Bao Yang
Central Eurasian vegetation is critical for the regional ecological security and the global carbon cycle. However, climatic impacts on vegetation growth in Central Eurasia are uncertain. The reason for this uncertainty lies in the fact that the response of vegetation to climate change showed nonlinearity, seasonality and differences among plant functional types. Based on remotely sensed vegetation index and in-situ meteorological data for the years 1982-2013, in conjunction with the latest land cover type product, we analyzed how vegetation growth trend varied across different seasons and evaluated vegetation response to climate variables at regional, biome and pixel scales...
December 2, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27919363/the-effects-of-statin-treatment-on-adrenal-and-sexual-function-and-nitric-oxide-levels-in-hypercholesterolemic-male-patients-treated-with-a-statin
#15
Osman Baspınar, Fahri Bayram, Selda Korkmaz, Murat Aksu, Derya Kocer, Oğuzhan Sıtkı Dizdar, Yasin Simsek, Peter P Toth
BACKGROUND: Erectile dysfunction complaints among men treated with a statin are not uncommon. OBJECTIVES: To evaluate the effect of lowering low-density lipoprotein cholesterol (LDL-C) to target levels using varying doses of atorvastatin therapy in hypercholesterolemic male patients on adrenocortical hormones, sexual functions, and serum nitric oxide (NO) levels. METHODS: Eleven hypercholesterolemic male patients who had LDL-C levels greater than 160 mg/dL were included in the study and 11 healthy male individuals served as controls...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27918686/utility-of-surveillance-research-to-inform-physical-activity-policy-an-exemplar-from-canada
#16
Cora L Craig, Christine A Cameron, Adrian Bauman
BACKGROUND: There are several well-known risk factor monitoring systems, but few examples of comprehensive surveillance systems designed specifically to inform physical activity (PA) policy. This paper examines the utility of Canada`s Physical Activity and Sport Monitoring System in guiding policy and practice. METHODS: Indicators were determined in conjunction with government, non-governmental associations and academics. Serial measures were collected from representative population (telephone interviews, n=4,000-11,000) and setting-based (postal surveys, n=1,425-4,304) surveys...
December 5, 2016: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/27918452/light-dark-shifting-promotes-alcohol-induced-colon-carcinogenesis-possible-role-of-intestinal-inflammatory-milieu-and-microbiota
#17
Faraz Bishehsari, Abdulrahman Saadalla, Khashayarsha Khazaie, Phillip A Engen, Robin M Voigt, Brandon B Shetuni, Christopher Forsyth, Maliha Shaikh, Martha Hotz Vitaterna, Fred Turek, Ali Keshavarzian
BACKGROUND: Colorectal cancer (CRC) is associated with the modern lifestyle. Chronic alcohol consumption-a frequent habit of majority of modern societies-increases the risk of CRC. Our group showed that chronic alcohol consumption increases polyposis in a mouse mode of CRC. Here we assess the effect of circadian disruption-another modern life style habit-in promoting alcohol-associated CRC. METHOD: TS4Cre × adenomatous polyposis coli (APC)(lox468) mice underwent (a) an alcohol-containing diet while maintained on a normal 12 h light:12 h dark cycle; or (b) an alcohol-containing diet in conjunction with circadian disruption by once-weekly 12 h phase reversals of the light:dark (LD) cycle...
December 2, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27918346/electrical-stimulation-for-seizure-induction-and-functional-mapping-in-stereoelectroencephalography
#18
Agnès Trébuchon, Patrick Chauvel
The challenge in epilepsy surgery is to remove the epileptogenic zone without compromising postoperative function. Electrical stimulation (ES) was developed to identify with greater anatomical and physiological precision cortical structures essential to language and motor function. Because the language network is widely distributed in the left (dominant) hemisphere, and often varies among patients, brain mapping should delineate eloquent areas at the individual level. Although ES for language is commonly performed during a presurgical investigation, the procedure remains nonstandardized among centers, and differences between grids and intracerebral depth electrodes (stereoelectroencephalography) should be taken into account when comparing results from different series...
December 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/27918201/the-importance-of-treating-by-histological-subtype-in-advanced-soft-tissue-sarcoma
#19
Javier Martín Broto, Axel Le Cesne, Peter Reichardt
While surgical resection (±radiotherapy) is standard treatment for localized soft tissue sarcomas (STS), chemotherapy is the mainstay for managing locally advanced and metastatic disease. Expanding knowledge of the biologies and sensitivities of STS histotypes, in conjunction with results from a growing collection of retrospective reviews and prospective randomized studies, point to the importance of treating in consideration of histological subtype. Doxorubicin ± ifosfamide continues to be standard first-line therapy for most STS subtypes...
January 2017: Future Oncology
https://www.readbyqxmd.com/read/27918026/infrared-dynamics-study-of-thermally-treated-perfluoroimide-acid-proton-exchange-membranes
#20
L Puskar, E Ritter, U Schade, M Yandrasits, S J Hamrock, M Schaberg, E F Aziz
The temperature induced dehydration process of the 3M Brand perfluoroimide acid (PFIA), an advanced proton exchange membrane for fuel cells, was studied by in situ infrared spectroscopy to understand proton transport processes under conditions of low hydration levels. A comprehensive assignment of the vibrational bands of PFIA in the mid infrared region is provided. Investigation of the kinetics in conjunction with 2D correlation spectroscopy methods revealed the sequential process of the hydration and dehydration in a conclusive model...
December 5, 2016: Physical Chemistry Chemical Physics: PCCP
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