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https://www.readbyqxmd.com/read/28812401/management-of-complicated-skin-and-skin-structure-infections-a-call-for-infectious-disease-specialists
#1
Arne Tärnvik
No abstract text is available yet for this article.
August 16, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28811336/catastrophic-unbalanced-genome-rearrangements-cause-somatic-loss-of-berry-color-in-grapevine
#2
Pablo Carbonell-Bejerano, Carolina Royo, Rafael Torres-Pérez, Jérôme Grimplet, Lucie Fernandez, Jose M Franco-Zorrilla, Diego Lijavetzky, Elisa Baroja, Juana Martínez, Enrique García-Escudero, Javier Ibáñez, José M Martínez-Zapater
Grape color somatic variants that can be used to develop new grapevine cultivars occasionally appear associated to deletion events of uncertain origin. To understand the mutational mechanisms generating somatic structural variation in grapevine, we compared the Tempranillo Blanco (TB) white berry somatic variant to its black berry ancestor, Tempranillo Tinto. Whole-genome sequencing (WGS) uncovered a catastrophic genome rearrangement in TB that caused the hemizygous deletion of 313 genes, including the loss of the functional copy for the MYB transcription factors required for anthocyanin pigmentation in the berry skin...
August 15, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28811226/characterization-and-expression-analysis-of-six-interleukin-17-receptor-genes-in-grouper-epinephelus-coioides-after-cryptocaryon-irritans-infection
#3
Biao Jiang, Yan-Wei Li, Ya-Zhou Hu, Heng-Li Luo, An-Xing Li
Interleukin-17 receptors (IL17Rs) mediate the activation of several downstream signal pathways to induce inflammatory response and contribute to the pathology of many autoimmune diseases. In this study, six IL17Rs (IL17RA1, RA2, RB, RC, RD and RE) were cloned and characterized from Epinephelus coioides, an orange-spotted grouper. Multiple sequence alignment and structural analysis revealed that all members of IL17Rs were low in sequence identity with each other. But their structures were conservative in grouper, which contain signal peptide, extracellular FNIII domain (IL17RA1/RA2/RB) or IL-17_R_N domain (IL17RC/RD/RE), transmembrane domain and SEFIR domain in their intracellular region...
August 12, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28811205/extraction-and-characterization-of-acid-soluble-and-pepsin-soluble-collagen-from-skin-of-loach-misgurnus-anguillicaudatus
#4
Jing Wang, Xinli Pei, Haiying Liu, Dan Zhou
Acid-soluble collagen (ASC) and pepsin-soluble collagen (PSC) were extracted from loach skin. The yields of ASC and PSC were 22.42% and 27.32%, respectively. Sodium dodecyl sulfate-polyacrylamide-gel electrophoresis and peptide mass fingerprint analysis revealed that loach skin contained type I collagen. There were 212 imino acids/1000 residues in ASC and 193 imino acids/1,000 residues in PSC. Fourier transform infrared spectrometry analysis, UV measurements and circular dichroism confirmed that loach skin collagen had a triple helical structure...
August 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28810476/experiences-of-stigma-over-the-lifetime-of-people-with-xeroderma-pigmentosum-a-qualitative-interview-study-in-the-united-kingdom
#5
Rebecca Anderson, Jessica Walburn, Myfanwy Morgan
This study explored experiences of stigma in 25 adults with xeroderma pigmentosum. Analysis of semi-structured interviews revealed the changing nature of stigma over the lifetime. Bullying occurred in childhood, whereas adults were questioned about both their photoprotection and skin damage, often resulting in internalised feelings of stigma. Resilience and rejection of feelings of stigma increased with age and experiences of stigma differed across cultures. Findings indicate a need to develop social skills training to help people reject feelings of stigma...
June 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28807615/interfacial-properties-of-avian-stratum-corneum-monolayers-investigated-by-brewster-angle-microscopy-and-vibrational-sum-frequency-generation
#6
Ellen M Adams, Alex M Champagne, Joseph B Williams, Heather C Allen
The outermost layer of skin, the stratum corneum (SC), contains a complex mixture of lipids, which controls the rate of cutaneous water loss (CWL) in reptiles, mammals, and birds. However, the molecular structure of SC lipids and how molecular configurations influence CWL is poorly understood. Here, the organization and structure of SC lipids extracted from birds were investigated by means of Langmuir films. Properties of lipids from the SC of arid and semi-arid adapted larks, known to have a low CWL, were compared with lipids extracted from the SC of mesic lark species with higher CWL to gain insight into how structure impacts CWL...
August 11, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28807341/ultrastructural-examination-of-skin-biopsies-may-assist-in-diagnosing-mitochondrial-cytopathy-when-muscle-biopsies-yield-negative-results
#7
John L McAfee, Christine B Warren, Richard A Prayson
Ultrastructural evaluation of skin biopsies has been utilized for diagnosis of mitochondrial disease. This study investigates how frequently skin biopsies reveal mitochondrial abnormalities, correlates skin and muscle biopsy findings, and describes clinical diagnoses rendered following the evaluation. A retrospective review of surgical pathology reports from 1990 to 2015 identified skin biopsies examined by electron microscopy for suspected metabolic disease. A total of 630 biopsies were included from 615 patients...
August 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28805671/the-roles-of-vitamin-c-in-skin-health
#8
REVIEW
Juliet M Pullar, Anitra C Carr, Margreet C M Vissers
The primary function of the skin is to act as a barrier against insults from the environment, and its unique structure reflects this. The skin is composed of two layers: the epidermal outer layer is highly cellular and provides the barrier function, and the inner dermal layer ensures strength and elasticity and gives nutritional support to the epidermis. Normal skin contains high concentrations of vitamin C, which supports important and well-known functions, stimulating collagen synthesis and assisting in antioxidant protection against UV-induced photodamage...
August 12, 2017: Nutrients
https://www.readbyqxmd.com/read/28805446/epigallocatechin-gallate-as-an-anti-obesity-therapeutic-compound-an-in-silico-approach-for-structure-based-drug-designing
#9
Muhammad Shahid Javaid, Noreen Latief, Bushra Ijaz, Usman Ali Ashfaq
Epigallocatechin gallate is a polyphenol of tea plants. Other than tea its trace amounts are found in apple skin, onions and plums. It has anti-adipogenic and anti-oxidant potential. It was investigated that epigallocatechin gallate stopped the adipogenic differentiation of mice mesenchymal stem cells but its underlying mechanism is not well understood. Different proteins and transcription factors responsible for differentiation of adipocytes could be its targets. This study was designed to determine the potential target of epigallocatechin gallate in human...
August 14, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28805367/tailoring-membrane-surface-properties-and-ultrafiltration-performances-via-self-assembly-of-polyethylene-glycol-block-polysulfone-block-polyethylene-glycol-block-copolymer-upon-thermal-and-solvent-annealing
#10
Ning Wang, Tao Wang, Yunxia Hu
Recently, ultrafiltration (UF) membranes faced great challenges including the fine control of the membrane surfaces for high filtration performances and antifouling properties in treating complex solution systems. Here, a particular type of amphiphilic block copolymers polyethylene glycol-block-polysulfone-block-polyethylene glycol (PEG-b-PSf-b-PEG) was synthesized through one-pot step-growth polymerization with mPEG as two ends to achieve the mobility of hydrophilic polymer chains. Without any other polymers or additives involved, the PEG-b-PSf-b-PEG triblock copolymer UF membrane was fabricated through the non-solvent induced phase separation (NIPS) method...
August 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28804856/toxic-effects-of-copper-on-liver-and-cholinesterase-of-clarias-gariepinus
#11
Siti Nadzirah Padrilah, Siti Aqlima Ahmad, Nur Adeela Yasid, Mohd Khalizan Sabullah, Hassan Mohd Daud, Ariff Khalid, Mohd Yunus Shukor
The release of pollutants, especially heavy metals, into the aquatic environment is known to have detrimental effects on such an environment and on living organisms including humans when those pollutants are allowed to enter the food chain. The aim of this study is to analyse the damage to Clarias gariepinus' liver caused by exposure to different concentrations of copper. In the present study, samples of C. gariepinus were exposed to sub-lethal copper sulphate (CuSO4) concentrations (from 0.2 to 20.0 mg/L) for 96 h...
August 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28801228/identification-of-the-first-cathelicidin-gene-from-skin-of-chinese-giant-salamanders-andrias-davidianus-with-its-potent-antimicrobial-activity
#12
Hui Yang, Baoyue Lu, Dandan Zhou, Lin Zhao, Weijia Song, Lixin Wang
Cathelicidins, as effector molecules, play important roles against infections and represent a crucial component of the innate immune system in vertebrates. They are widely studied in mammals, but little is known in amphibians. In the present study, we report the identification and characterization of a novel cathelicidin from Chinese giant salamander Andrias davidianus, which is the first study in Caudata amphibian. The cDNA sequence encodes a predicted 148-amino-acid polypeptide, which composed of a 20-residue signal peptide, a 94-residue conserved cathelin domain and a 34-residue mature peptide...
August 9, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28801096/a-comparative-study-of-the-properties-and-self-aggregation-behavior-of-collagens-from-the-scales-and-skin-of-grass-carp-ctenopharyngodon-idella
#13
Yaowen Liu, Donghui Ma, Yihao Wang, Wen Qin
Collagens were extracted from the scales and skin of Ctenopharyngodon idella (C. idella) as raw materials using an acid-enzyme hybrid method. The structural properties of the extracted collagens were compared using ultraviolet-visible spectrophotometry, Fourier transform infrared spectroscopy, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and differential scanning calorimetry. Additionally, the in vitro self-aggregation behaviors of the two types of collagens (fish skin- and scale-derived collagens) were compared using turbidimetric assays, aggregation assays, and scanning electron microscopy (SEM)...
August 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28800526/identification-and-determination-of-related-substances-of-ceftaroline-fosamil-in-medicinal-product-by-high-performance-liquid-chromatography-with-diode-array-detection-and-tandem-mass-spectrometry
#14
Izabela Karpiuk, Katarzyna Michalska, Katarzyna Bus, Monika Kiljan, Stefan Tyski
Ceftaroline fosamil, the prodrug of ceftaroline, is an advanced-generation cephalosporin antibacterial agent approved for treatment in the European Union in 2012. The drug is dedicated to curing complicated skin and soft tissue infections and community-acquired pneumonia. The developed analytical method of high performance liquid chromatography (HPLC) followed by diode array detector (DAD) set at 243nm was used to identify and determine degradation products of ceftaroline fosamil. The elaborated method demonstrated good selectivity and linearity [r>0...
August 1, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28797092/studies-of-the-antitumor-mechanism-of-action-of-dermaseptin-b2-a-multifunctional-cationic-antimicrobial-peptide-reveal-a-partial-implication-of-cell-surface-glycosaminoglycans
#15
Célia Dos Santos, Sabah Hamadat, Karen Le Saux, Clara Newton, Meriem Mazouni, Loussiné Zargarian, Mickael Miro-Padovani, Patricia Zadigue, Jean Delbé, Yamina Hamma-Kourbali, Mohamed Amiche
Dermaseptin-B2 (DRS-B2) is a multifunctional cationic antimicrobial peptide (CAP) isolated from frog skin secretion. We previously reported that DRS-B2 possesses anticancer and antiangiogenic activities in vitro and in vivo. In the present study, we evaluated the antiproliferative activity of DRS-B2 on numerous tumor cell lines, its cell internalization and studies of its molecular partners as well as their influences on its structure. Confocal microscopy using ([Alexa594]-(Cys0)-DRS-B2) shows that in sensitive human tumor cells (PC3), DRS-B2 seems to accumulate rapidly at the cytoplasmic membranes and enters the cytoplasm and the nucleus, while in less sensitive tumor cells (U87MG), DRS-B2 is found packed in vesicles at the cell membrane...
2017: PloS One
https://www.readbyqxmd.com/read/28797059/general-theory-of-skin-reinforcement
#16
Ilja L Kruglikov, Philipp E Scherer
Macroscopic mechanical properties of human skin in vivo cannot be considered independent of adjacent subcutaneous white adipose tissue (sWAT). The layered system skin/sWAT appears as the hierarchical structural composite in which single layers behave as fiber-reinforced structures. Effective macroscopic mechanical properties of such composites are mainly determined either by the properties of the skin or by those of the sWAT, dependent on the conditions of mechanical loading. Mechanical interactions between the skin and the adjacent sWAT associated with a mismatch in the mechanical moduli of these two layers can lead to production of the skin wrinkles...
2017: PloS One
https://www.readbyqxmd.com/read/28795212/a-review-of-adverse-events-related-to-prostatic-artery-embolization-for-treatment-of-bladder-outlet-obstruction-due-to-bph
#17
Airton Mota Moreira, André Moreira de Assis, Francisco Cesar Carnevale, Alberto Azoubel Antunes, Miguel Srougi, Giovanni Guido Cerri
INTRODUCTION: Minimally invasive procedures have gained great importance among the treatments for benign prostate hyperplasia (BPH) due to their low morbidity. Prostate artery embolization has emerged as a safe and effective alternative for patients with large volume BPH, not suited for surgery. MATERIALS AND METHODS: Low adverse events rates have been reported following prostate artery embolization and may include dysuria, urinary infection, hematuria, hematospermia, acute urinary retention and rectal bleeding...
August 9, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28794647/cefazolin-potency-against-methicillin-resistant-staphylococcus-aureus-a-microbiologic-assessment-in-support-of-a-novel-drug-delivery-system-for-skin-and-skin-structure-infections
#18
David P Nicolau, Barry N Silberg
INTRODUCTION: Despite aggressive medical and surgical management, the resolution of skin and skin structure infections is often difficult due to insufficient host response, reduced drug penetration, and a high prevalence of resistance organisms such as methicillin-resistant Staphylococcus aureus (MRSA). As a result of these factors, conventional management often consists of prolonged broad-spectrum systemic antimicrobials. An alternative therapy in development, ultrasonic drug dispersion (UDD), uses a subcutaneous injection followed by external trans-cutaneous ultrasound to deliver high tissue concentrations of cefazolin with limited systemic exposure...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28794552/histopathological-analysis-of-skin-adnexal-tumors-a-three-year-study-of-110-cases-at-a-tertiary-care-center
#19
Kanwalpreet Kaur, Karuna Gupta, Deepika Hemrajani, Ajay Yadav, Kalpana Mangal
BACKGROUND: Skin adnexal tumors (SAT) encompass wide spectrum of benign and malignant tumors that differentiate toward one or more adnexal structures found in normal skin. Overall incidence of SATs is low yet they can be challenging to diagnose. AIMS: The aim of this study is to study the spectrum and microscopic features of SATs. MATERIALS AND METHODS: It was a retrospective cross-sectional, descriptive study conducted over a period of 3 years...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28794452/the-anti-influenza-m2e-antibody-response-is-promoted-by-xcr1-targeting-in-pig-skin
#20
Charlotte Deloizy, Even Fossum, Christophe Barnier-Quer, Céline Urien, Tiphany Chrun, Audrey Duval, Maelle Codjovi, Edwige Bouguyon, Pauline Maisonnasse, Pierre-Louis Hervé, Céline Barc, Olivier Boulesteix, Jérémy Pezant, Christophe Chevalier, Nicolas Collin, Marc Dalod, Bjarne Bogen, Nicolas Bertho, Isabelle Schwartz-Cornil
XCR1 is selectively expressed on a conventional dendritic cell subset, the cDC1 subset, through phylogenetically distant species. The outcome of antigen-targeting to XCR1 may therefore be similar across species, permitting the translation of results from experimental models to human and veterinary applications. Here we evaluated in pigs the immunogenicity of bivalent protein structures made of XCL1 fused to the external portion of the influenza virus M2 proton pump, which is conserved through strains and a candidate for universal influenza vaccines...
August 9, 2017: Scientific Reports
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