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https://www.readbyqxmd.com/read/28322849/trans-cinnamic-acid-and-xenorhabdus-szentirmaii-metabolites-synergize-the-potency-of-some-commercial-fungicides
#1
Selcuk Hazir, David I Shapiro-Ilan, Clive H Bock, Luis G Leite
Development of novel approaches for the control of fungal phytopathogens is desirable. In this study we hypothesized that the combination of commercial fungicides with certain enhancing agents could result in synergistic levels of control. Prior research has indicated that trans-cinnamic-acid (TCA), a metabolite of the bacteria Photorhabdus luminescens and metabolites of Xenorhabdus szentirmaii are particularly toxic to various phytpathogenic fungi when compared to metabolites of other Xenorhabdus or Photorhabdus spp...
March 18, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28319397/a-scalable-platform-for-structured-and-hybrid-soft-nanocolloids-by-continuous-precipitation-in-a-confined-environment
#2
Victoria E Lee, Chris Sosa, Rui Liu, Robert K Prud'homme, Rodney D Priestley
Geometrically-structured polymer nanocolloids, including Janus nanocolloids, have been widely investigated for their unique properties, which are derived from their anisotropy. Controlled surface decoration with inorganic nanoparticles could induce another level of functionality into structured nanocolloids that could enable applications in fields ranging from re-writeable electronics to biphasic catalysis. Here, we demonstrate Flash NanoPrecipitation (FNP), as a one-step and scalable process platform to manufacture hybrid polymer-inorganic nanocolloids in which one phase is selectively decorated with a metal nanocatalyst by tuning the molecular interactions between the feed ingredients during the process...
March 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28317609/analysis-of-nitrite-and-nitrate-in-foods-overview-of-chemical-regulatory-and-analytical-aspects
#3
L Merino, U Örnemark, F Toldrá
In this chapter, several factors that should be considered for selecting and developing suitable analytical methods for determining nitrite/nitrate are presented. Nitrite and nitrate occurrence and suitability are a controversial issue. Nitrite is an approved additive considered a foremost curing ingredient for the preservation of meat products. Nitrate is a natural constituent of the human diet that, however, raises fears for its suggested potential harmfulness related to carcinogenesis and environmental contamination...
2017: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/28317603/protein-hydrolysates-and-biopeptides-production-biological-activities-and-applications-in-foods-and-health-benefits-a-review
#4
M Nasri
In recent years, a great deal of interest has been expressed regarding the production, characterization, and applications of protein hydrolysates and food-derived biopeptides due to their numerous beneficial health effects. In this regard, research is mainly focused on investigating the therapeutic potential of these natural compounds. Based on their amino acids composition, sequences, hydrophobicity, and length, peptides released from food proteins, beyond their nutritional properties, can exhibit various biological activities including antihypertensive, antioxidative, antithrombotic, hypoglycemic, hypocholesterolemic, and antibacterial activities among others...
2017: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/28317602/nanotechnology-approaches-for-increasing-nutrient-bioavailability
#5
S M Jafari, D J McClements
Health-promoting ingredients such as phenolic compounds, vitamins, and minerals are being increasingly introduced into foods and beverages to produce "functional foods" specifically designed to improve human health, well-being, and performance. However, it is often challenging to incorporate these nutraceuticals into foods because they have poor solubility characteristics, impart undesirable flavor profiles, are chemically unstable, or have low bioavailability. This problem can often be overcome by encapsulating the bioactive components in nanoparticle-based delivery systems...
2017: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/28317483/a-critical-review-of-bioactive-food-components-and-of-their-functional-mechanisms-biological-effects-and-health-outcomes
#6
Rosa Pérez-Gregorio, Jesús Simal-Gándara
BACKGROUND: Eating behaviours are closely related to some medical conditions potentially leading to death such as cancer, cardiovascular disease and diabetes. Healthy eating practices, maintaining a normal weight, and regular physical activity could prevent up to 80% of coronary heart disease, 90% of type-2 diabetes and one-third of all cancers[1]. METHOD: Over the last two decades, the food industry has invested much effort in research and development of healthier, more nutritious foods...
March 17, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28316254/plant-protein-based-feeds-and-commercial-feed-enable-isotopic-tracking-of-aquaculture-emissions-into-marine-macrozoobenthic-bioindicator-species
#7
Henrik Kusche, Nicola Hillgruber, Yvonne Rößner, Ulfert Focken
Brittle stars (Ophiura spp.) and other benthic macrofauna were collected in a prospective mariculture area in the North Sea to determine if these taxa could be used as indicator species to track nutrients released from future offshore aquaculture sites. We analysed natural carbon and nitrogen stable isotopic signatures in tissues from macrofauna and compared these to six feed ingredients and four experimental diets made thereof, as well as to a commercial feed with and without lipid and carbonate removal. Our data suggest practicability of using isotopic signatures of Ophiura spp...
March 20, 2017: Isotopes in Environmental and Health Studies
https://www.readbyqxmd.com/read/28302416/plant-parts-substitution-based-approach-as-a-viable-conservation-strategy-for-medicinal-plants-a-case-study-of-premna-latifolia-roxb
#8
Ashish Kumar Jena, Maninder Karan, Karan Vasisht
BACKGROUND: Rapid population growth and catastrophic harvesting methods of wild medicinal plants especially trees, result in the exploitation of natural sources and its management is the need of the hour. Dashamoolarishta is an amalgam of roots of ten plants of a popular Ayurvedic FDC formulation consisting of the root of Premna latifolia Roxb. as one of its ingredients. Presently, their populations like many other trees are under threat due to extensive use of the roots by the herbal drug industry...
March 14, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28302396/supercritical-antisolvent-co-precipitation-of-rifampicin-and-ethyl-cellulose
#9
Rania Djerafi, Andri Swanepoel, Christelle Crampon, Lonji Kalombo, Philip Labuschagne, Elisabeth Badens, Yasmine Masmoudi
Rifampicin-loaded submicron-sized particles were prepared through supercritical anti-solvent process using ethyl cellulose as polymeric encapsulating excipient. Ethyl acetate and a mixture of ethyl acetate/dimethyl sulfoxide (70/30 and 85/15) were used as solvents for both drug and polymeric excipient. When ethyl acetate was used, rifampicin was crystallized separately without being embedded within the ethyl cellulose matrix while by using the ethyl acetate/dimethyl sulfoxide mixture, reduced crystallinity of the active ingredient was observed and a simultaneous precipitation of ethyl cellulose and drug was achieved...
March 14, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28302224/-advances-in-the-research-of-the-regulation-of-chinese-traditional-medicine-monomer-and-its-derivatives-on-autophagy-in-non-small-cell-lung-cancer
#10
Meiyi Xiang, Ruilei Li, Zhiwei Zhang, Xin Song
The high morbidity and mortality of non-small cell lung cancer (NSCLC) did influence the quality of life of tumor patients world-wide. There is an urgent need to develop new therapies that have high anti-tumor activity and low toxicity side effects. It is widely accepted that autophagy can play diverse roles in carcinogenesis, such as induces pro-death of lung cancer cells or helps the escape from cell death, making it become a proper anticancer target. It's believed that various monomers of Chinese traditional medicine closely correlates to anti-NSCLC activities, and that even could affect the acquired multiple drug resistance (MDR)...
March 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28292236/microwave-assisted-olefin-metathesis-as-pivotal-step-in-the-synthesis-of-bioactive-compounds
#11
Koffi Sénam Etsè, Alice Ngendera, Nelly Tshibalonza Ntumba, Albert Demonceau, Lionel Delaude, Ileana Dragutan, Valerian Dragutan
Over the last two decades, olefin metathesis has emerged as a new avenue in the design of new routes for the synthesis of natural products and active pharmaceutical ingredients. In many cases, syntheses based on olefin metathesis strategies provide elegant routes in terms of increasing the overall yields, improving the synthesis scope, and decreasing the number of steps. On the other hand, over the last decade, microwave-assisted chemistry has experienced an incredible development, which rapidly opened new vistas in organic synthesis and in homogeneous catalysis...
March 14, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28289761/a-new-biochromatography-model-based-on-dna-origami-assembled-ppar%C3%AE-construction-and-evaluation
#12
Jie Zhou, Lingchang Meng, Chong Sun, Shanshan Chen, Fang Sun, Pei Luo, Yongxing Zhao
As drug targets, receptors have potential to screen drugs. Silica is an attractive support to immobilize receptors; however, the lack of biocompatibility makes it easier for receptors to lose bioactivity, which remains an obstacle to its widespread use. With the advantage of biocompatibility, DNA origami can be used as a biological carrier to improve the biocompatibility of silica and assemble receptors. In this study, a new biochromatography model based on DNA origami was constructed. A large quantity of M13ssDNA was used as a scaffold, leading to significant costs, so M13ssDNA was self-produced from the bacteriophage particles...
March 13, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28285779/saponins-self-assembly-and-behavior-at-aqueous-interfaces
#13
REVIEW
Sandra Böttcher, Stephan Drusch
Saponins are interfacially active ingredients in plants consisting of a hydrophobic aglycone structure with hydrophilic sugar residues. Variations in aglycone structure as well as type and amount of sugar residues occur depending on the botanical origin. Saponins are a heterogeneous and broad class of natural substances and therefore the relationship between molecular structure and interfacial properties is complex and, yet, not completely understood. A wide range of research focused either on structural elucidation of saponins or interfacial properties...
March 1, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28283686/-topical-therapy-of-the-scalp
#14
REVIEW
J Wohlrab, J Michael
Various hair-related diseases, systemic dermatoses as well as parasitic diseases are treated via topical application of active substances. The density of hair follicles and the consequential special conditions for diffusion require specific galenic concepts that can vary considerably depending on the respective therapeutic purpose. Both the physicochemical properties of the active ingredient and the nature of the application area must be considered when choosing an appropriate galenic base. Highly relevant here are hairiness, scarring, hyperkeratosis and exoserosis...
March 10, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28279788/containment-challenges-in-hpapi-manufacture-for-adc-generation
#15
REVIEW
Elizabeth Dunny, Imelda O'Connor, Jonathan Bones
Antibody-drug conjugates (ADCs) are emerging as an impactful class of therapeutics for the treatment of cancer because of their ability to harness the specificity of an antibody and the cytotoxic potential of the payload to target and destroy cancer cells. However, the potent nature of the cytotoxic payload creates associated manufacturing challenges for active pharmaceutical ingredient (API) manufacturers, because huge investment in containment technology is required to ensure the protection of operators and the environment...
March 6, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28278224/ampk-modulatory-activity-of-olive-tree-leaves-phenolic-compounds-bioassay-guided-isolation-on-adipocyte-model-and-in-silico-approach
#16
Cecilia Jiménez-Sánchez, Mariló Olivares-Vicente, Celia Rodríguez-Pérez, María Herranz-López, Jesús Lozano-Sánchez, Antonio Segura-Carretero, Alberto Fernández-Gutiérrez, José Antonio Encinar, Vicente Micol
SCOPE: Olive-tree polyphenols have demonstrated potential for the management of obesity-related pathologies. We aimed to explore the capacity of Olive-tree leaves extract to modulate triglyceride accumulation and AMP-activated protein kinase activity (AMPK) on a hypertrophic adipocyte model. METHODS: Intracellular triglycerides and AMPK activity were measured on the hypertrophic 3T3-L1 adipocyte model by AdipoRed and immunofluorescence microscopy, respectively. Reverse phase high performance liquid chromatography coupled to time-of-flight mass detection with electrospray ionization (RP-HPLC-ESI-TOF/MS) was used for the fractionation of the extract and the identification of the compounds...
2017: PloS One
https://www.readbyqxmd.com/read/28278110/optimization-of-penicillium-aurantiogriseum-protease-immobilization-on-magnetic-nanoparticles-for-antioxidant-peptides-obtainment
#17
José Manoel Wanderley Duarte Neto, Jackeline da Costa Maciel, Júlia Furtado Campos, Luiz Bezerra de Carvalho Junior, Daniela Araújo Viana Marques, Carolina de Albuquerque Lima, Ana Lúcia Figueiredo Porto
This work reports an optimization of protease from Penicillium aurantiogriseum immobilization on polyaniline coated magnetic nanoparticles for antioxidant peptides obtainment derived from bovine casein. Immobilization process was optimized using a full two-level factorial design (2(4)) followed by a response surface methodology (RSM). Using the derivative, casein was hydrolyzed uncovering its peptides that were sequenced and had antioxidant properties tested via ABTS radical scavenging and Hydrogen peroxide scavenging assays...
February 10, 2017: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/28277582/experimental-investigation-of-the-reaction-of-helium-ions-with-dimethyl-ether-stereodynamics-of-the-dissociative-charge-exchange-process
#18
Andrea Cernuto, Paolo Tosi, Luca Matteo Martini, Fernando Pirani, Daniela Ascenzi
The fate of dimethyl ether (DME, CH3OCH3) in collisions with He(+) ions is of high relevance for astrochemical models aimed at reproducing the abundances of complex organic molecules in the interstellar medium. Here we report an investigation on the reaction of He(+) ions with DME carried out using a Guided Ion Beam Mass Spectrometer (GIB-MS), which allows the measurement of reactive cross-sections and branching ratios (BRs) as a function of the collision energy. We obtain insights into the dissociative charge (electron) exchange mechanism by investigating the nature of the non-adiabatic transitions between the relevant potential energy surfaces (PESs) in an improved Landau-Zener approach...
March 9, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28277195/induction-of-apoptosis-by-berberine-in-hepatocellular-carcinoma-hepg2-cells-via-downregulation-of-nf-%C3%AE%C2%BAb
#19
Min Li, Mao Zhang, Zhi-Lang Zhang, Ning Liu, Xiao-Yu Han, Qin-Cheng Liu, Wei-Jun Deng, Cai-Xian Liao
Hepatocellular carcinoma (HCC) is highly resistant to traditional chemotherapeutic approaches, which causes difficulty in the development of effective drugs for the treatment of HCC. Berberine, a major ingredient of Rhizoma coptidis, is a natural alkaloid used in traditional Chinese medicine. Berberine exhibits potent antitumor activity against HCC due to its high efficiency and low toxicity. In the present study, we found that berberine sensitized HepG cells to NF-κB-mediated apoptosis. Berberine exhibited a significant antiproliferation effect on the HepG2 cells and promoted apoptosis...
January 26, 2017: Oncology Research
https://www.readbyqxmd.com/read/28276289/natural-antioxidants-in-the-treatment-and-prevention-of-diabetic-nephropathy-a-potential-approach-that-warrants-clinical-trials
#20
Noori Al-Waili, Hamza Al-Waili, Thia Al-Waili, Khelod Salom
Diabetic nephropathy is the major cause of end-stage renal disease and effective and new therapeutic approaches are needed in diabetic nephropathy and chronic kidney diseases. Oxidative stress and inflammatory process are important factors contributing to kidney damage by increasing production of oxidants. KEAP1/Nrf2/ARE pathway regulates the transcription of many antioxidant genes and modulation of the pathway up regulates antioxidants. NFB controls the expression of genes involved in the inflammatory response...
March 9, 2017: Redox Report: Communications in Free Radical Research
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