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https://www.readbyqxmd.com/read/27920772/streptococcus-thermophilus-apc151-strain-is-suitable-for-the-manufacture-of-naturally-gaba-enriched-bioactive-yogurt
#1
Daniel M Linares, Tom F O'Callaghan, Paula M O'Connor, R P Ross, Catherine Stanton
Consumer interest in health-promoting food products is a major driving force for the increasing global demand of functional (probiotic) dairy foods. Yogurt is considered the ideal medium for delivery of beneficial functional ingredients. Gamma-amino-butyric acid has potential as a bioactive ingredient in functional foods due to its health-promoting properties as an anti-stress, anti-hypertensive, and anti-diabetic agent. Here, we report the use of a novel Streptococcus thermophilus strain, isolated from the digestive tract of fish, for production of yogurt naturally enriched with 2 mg/ml of gamma-amino-butyric acid (200 mg in a standard yogurt volume of 100 ml), a dose in the same range as that provided by some commercially available gamma-amino-butyric acid supplements...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27919554/quantitative-structure-property-relationships-for-predicting-sorption-of-pharmaceuticals-to-sewage-sludge-during-waste-water-treatment-processes
#2
L Berthod, D C Whitley, G Roberts, A Sharpe, R Greenwood, G A Mills
Understanding the sorption of pharmaceuticals to sewage sludge during waste water treatment processes is important for understanding their environmental fate and in risk assessments. The degree of sorption is defined by the sludge/water partition coefficient (Kd). Experimental Kd values (n=297) for active pharmaceutical ingredients (n=148) in primary and activated sludge were collected from literature. The compounds were classified by their charge at pH7.4 (44 uncharged, 60 positively and 28 negatively charged, and 16 zwitterions)...
December 2, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27917960/a-vision-for-the-future-of-pastoralism
#3
J Zinsstag, B Bonfoh, G Zinsstag, L Crump, I O Alfaroukh, M F Abakar, J Kasymbekov, Z Baljinnyam, K Liechti, M A Seid, E Schelling
Pastoral regions are challenged by social and ecological changes. Yet, there is increasingly robust evidence that pastoralism is a viable and sustainable livelihood and that pastoralists play a role in attaining the United Nations Sustainable Development Goals (SDGs). In this issue of the Scientific and Technical Review of the World Organisation for Animal Health (OIE), the authors take a broad view of pastoralism and pastoral livestock production from a number of different perspectives, taking into account societal and ecological viewpoints as well as issues of animal and human health...
November 2016: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/27917952/biodiversity-in-models-of-cyclic-dominance-is-preserved-by-heterogeneity-in-site-specific-invasion-rates
#4
Attila Szolnoki, Matjaž Perc
Global, population-wide oscillations in models of cyclic dominance may result in the collapse of biodiversity due to the accidental extinction of one species in the loop. Previous research has shown that such oscillations can emerge if the interaction network has small-world properties, and more generally, because of long-range interactions among individuals or because of mobility. But although these features are all common in nature, global oscillations are rarely observed in actual biological systems. This begets the question what is the missing ingredient that would prevent local oscillations to synchronize across the population to form global oscillations...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27916819/the-nutritional-value-and-health-benefits-of-chickpeas-and-hummus
#5
REVIEW
Taylor C Wallace, Robert Murray, Kathleen M Zelman
The 2015-2020 Dietary Guidelines for Americans advocate for increasing vegetable intake and replacing energy-dense foods with those that are nutrient-dense. Most Americans do not eat enough vegetables, and particularly legumes, each day, despite their well-established benefits for health. Traditional hummus is a nutrient-dense dip or spread made from cooked, mashed chickpeas, blended with tahini, olive oil, lemon juice, and spices. Consumers of chickpeas and/or hummus have been shown to have higher nutrient intakes of dietary fiber, polyunsaturated fatty acids, vitamin A, vitamin E, vitamin C, folate, magnesium, potassium, and iron as compared to non-consumers...
November 29, 2016: Nutrients
https://www.readbyqxmd.com/read/27910755/comparison-of-the-composition-and-antioxidant-activities-of-phenolics-from-the-fruiting-bodies-of-cultivated-asian-culinary-medicinal-mushrooms
#6
Shaoling Lin, Lai Tsz Ching, Xinxin Ke, Peter Chi Keung Cheung
The composition profile and the antioxidant properties of phenolics in water extracts obtained from the fresh fruiting bodies of 4 common cultivated Asian edible mushrooms-Agrocybe aegerita, Pleurotus ostreatus, P. eryngii, and Pholiota nameko were compared. The water extract from A. aegerita (AaE) had the highest total phenolic content (TPC) at 54.18 ± 0.27 gallic acid equivalents (μmol/L)/mg extract (P < 0.05), as measured by the Folin-Ciocalteu method, and consisted of the largest number (including gallic acid, protocatechuic acid, chlorogenic acid, ferulic acid, and sinapic acid) and total amounts of phenolic acids identified by Fourier transform-ion cyclotron resonance mass spectrometry...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27900434/combination-of-microbiological-spectroscopic-and-molecular-docking-techniques-to-study-the-antibacterial-mechanism-of-thymol-against-staphylococcus-aureus-membrane-damage-and-genomic-dna-binding
#7
Lang-Hong Wang, Zhi-Hong Zhang, Xin-An Zeng, De-Ming Gong, Man-Sheng Wang
Thymol (2-isopropyl-5-methylphenol) is a natural ingredient used as flavor or preservative agent in food products. The antibacterial mechanism of thymol against Gram-positive, Staphylococcus aureus was investigated in this work. A total of 15 membrane fatty acids were identified in S. aureus cells by gas chromatography-mass spectrometry. Exposure to thymol at low concentrations induced obvious alterations in membrane fatty acid composition, such as decreasing the proportion of branched 12-methyltetradecanoic acid and 14-methylhexadecanoic acid (from 22...
November 29, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27896684/use-of-spray-dried-dispersions-in-early-pharmaceutical-development-theoretical-and-practical-challenges
#8
Jinjiang Li, Dhaval Patel, George Wang
Spray-dried dispersions (SDDs) have become an important formulation technology for the pharmaceutical product development of poorly water-soluble (PWS) compounds. Although this technology is now widely used in the industry, especially in the early-phase development, the lack of mechanistic understanding still causes difficulty in selecting excipients and predicting stability of SDD-based drug products. In this review, the authors aim to discuss several principles of polymer science pertaining to the development of SDDs, in terms of selecting polymers and solvents, optimizing drug loading, as well as assessing physical stability on storage and supersaturation maintenance after dissolution, from both thermodynamic and kinetic considerations...
November 28, 2016: AAPS Journal
https://www.readbyqxmd.com/read/27891158/natural-active-ingredients-for-diabetes-and-metabolism-disorders-treatment
#9
EDITORIAL
Hilal Zaid, Abbas A Mahdi, Akhilesh K Tamrakar, Bashar Saad, Mohammed S Razzaque, Amitava Dasgupta
No abstract text is available yet for this article.
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27886388/phytate-calcium-molar-ratio-does-not-predict-accessibility-of-calcium-in-ready-to-eat-dishes
#10
Daniela Erba, Federica Manini, Erika Meroni, Maria C Casiraghi
BACKGROUND: Phytic acid (PA), a naturally occurring compound of plant food, is generally considered to affect mineral bioavailability. The aim of this study was to investigate the reliability of the PA/calcium molar ratio as a predictive factor of calcium accessibility in composed dishes and their ingredients. RESULTS: We chose dishes whose ingredients were rich in Ca (milk or cheese) or in PA (whole-wheat cereals) in order to consider a range of PA/Ca ratios (from 0 to 2...
November 25, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27872932/phytochemical-profiles-of-marine-phytoplanktons-an-evaluation-of-their-in-vitro-antioxidant-and-anti-proliferative-activities
#11
Jim Jun-Hui Huang, Wen-Wen Xu, Shao-Ling Lin, Peter Chi-Keung Cheung
Marine microorganisms such as phytoplanktons are a rich resource of bioactive components with antioxidant and anti-proliferative activities that can act as novel functional food ingredients. In this study, the pigment profiles, total mycosporine-like amino acids (MAAs) and total phenolic contents (TPCs) in solvent extracts including 90% acetone and methanol from five marine phytoplanktons including Nitzschia closterium (Bacillariophyta), Isochrysis zhangjiangensis (Haptophyta), Platymonas subcordiformis (Chlorophyta), Porphyridium cruentum (Rhodophyta) and Synechocystis pevalekii (Cyanobacteria) were analyzed...
November 22, 2016: Food & Function
https://www.readbyqxmd.com/read/27869223/insight-into-the-metabolic-mechanism-of-scoparone-on-biomarkers-for-inhibiting-yanghuang-syndrome
#12
Heng Fang, Aihua Zhang, Jingbo Yu, Liang Wang, Chang Liu, Xiaohang Zhou, Hui Sun, Qi Song, Xijun Wang
Scoparone (6,7-dimethoxycoumarin) is the representative ingredient of Yinchenhao (Artemisia capillaris Thunb.) which is a famous Chinese medicinal herb and shows favorable efficacy for all kinds of liver disease, specifically for the treatment of Yanghuang syndrome (YHS). The precise molecular mechanism concerning the action of scoparone on YHS is yet to be fully elucidated. The aim of the present study was to determine the mechanism of scoparone and evaluate its efficacy on metabolite levels. The differential expression of metabolites responsible for the pharmacological effects of scoparone was characterized and the protection effect of scoparone against this disease...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27868152/effect-of-buffalo-casein-derived-novel-bioactive-peptides-on-osteoblast-differentiation
#13
Srinu Reddi, Venkatesa Perumal Shanmugam, Kemgang Sonfack Tanedjeu, Suman Kapila, Rajeev Kapila
PURPOSE: Epidemiological and intervention studies show that milk consumption in childhood and during adolescence is related to higher bone mineral density. Milk and milk products prevent the bone loss in pre- and postmenopausal women. Apart from calcium, there are other biologically active compounds in milk such as bioactive peptides which may play a role in promoting bone health. Casein is the major protein in milk which has also been reported to have numerous biological active peptides within it...
November 21, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27866826/the-impact-of-online-therapeutic-feedback-on-outcome-measures-in-internet-cbti-for-adolescents-with-insomnia
#14
Eduard Jan de Bruin, Anne Marie Meijer
BACKGROUND: Guided Internet cognitive behavioral therapy for insomnia (CBTI) offers an effective treatment for adolescents, but little is known about the active ingredients of therapeutic feedback on outcomes. OBJECTIVE: This study aims to identify which factors can be distinguished in written therapeutic feedback in Internet CBTI, and examine whether these factors and participation in a chat session contribute to sleep outcomes. METHODS: Internet CBTI was applied to 57 adolescents (mean age 15...
September 13, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27851907/the-depigmenting-effect-of-natural-resorcinol-type-polyphenols-kuwanon-o-and-sanggenon-t-from-the-roots-of-morus-australis
#15
Shuting Hu, Zongping Zheng, Feng Chen, Mingfu Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Morus australis, one of the major Morus species growing in East Asia, is rich in phenolic compounds. The extract of M. australis has been used as skin whitening components for a long period. The action mechanisms of its principal constituents are still unclear. This study aims to evaluate the skin lightening effects of phenolic compounds extracted from the root of M. australis in different melanocyte systems and artificial skin models. MATERIALS AND METHODS: The depigmenting effect of resorcinol type polyphenols (RTPs) from the root extract of M...
November 13, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27846249/the-anthelmintic-ingredient-moxidectin-negatively-affects-seed-germination-of-three-temperate-grassland-species
#16
Carsten Eichberg, Manuel Wohde, Kerstin Müller, Anja Rausch, Christina Scherrmann, Theresa Scheuren, Rolf-Alexander Düring, Tobias W Donath
In animal farming, anthelmintics are regularly applied to control gastrointestinal nematodes. There is plenty of evidence that also non-target organisms, such as dung beetles, are negatively affected by residues of anthelmintics in faeces of domestic ungulates. By contrast, knowledge about possible effects on wild plants is scarce. To bridge this gap of knowledge, we tested for effects of the common anthelmintic formulation Cydectin and its active ingredient moxidectin on seed germination. We conducted a feeding experiment with sheep and germination experiments in a climate chamber...
2016: PloS One
https://www.readbyqxmd.com/read/27843333/water-soluble-egg-membrane-enhances-the-immunoactivating-properties-of-an-aloe-vera-based-extract-of-nerium-oleander-leaves
#17
Kathleen F Benson, Robert A Newman, Gitte S Jensen
OBJECTIVE: To evaluate a blend of two natural ingredients on immune parameters relevant for their current topical use and potential support of microcirculation in skin tissue. MATERIALS AND METHODS: A blend (BL) of Aloe vera-based Nerium oleander extract (NAE-8i, oleandrin-free) and hydrolyzed water-soluble egg membrane (WSEM) was applied to human whole-blood cultures for 24 hours, with each separate ingredient serving as a control. Immune-cell subsets were analyzed for expression levels of the activation markers CD69 and CD25...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27834826/inflammasomes-and-natural-ingredients-towards-new-anti-inflammatory-agents
#18
REVIEW
Patrick Dutartre
Inflammasomes are a family of proteins in charge of the initiation of inflammatory process during innate immune response. They are now considered major actors in many chronic inflammatory diseases. However, no major drug focusing on this target is currently on the market. Among the various approaches aiming to control this major metabolic pathway, compounds aiming to modify the intracellular antioxidant profile appear to be promising. This can be obtained by "light" antioxidants able to induce natural antioxidant response of the cell itself...
November 8, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27834107/a-critical-review-of-the-literature-to-conduct-a-toxicity-assessment-for-oral-exposure-to-methyl-salicylate
#19
Tracy Greene, Sarah Rogers, Allison Franzen, Robinan Gentry
Methyl salicylate is the predominant constituent of oil of wintergreen and is used as a pesticide, a denaturant, an external analgesic, a fragrance ingredient, and a flavoring agent in products such as chewing gum, baked goods, syrups, candy, beverages, ice cream, and tobacco products; and it occurs naturally in some vegetables and berries. Methyl salicylate is of interest to the tobacco industry as oil of wintergreen is used as a flavorant in tobacco products. The purpose of this investigation was to conduct a critical review of the available literature for oral exposure to methyl salicylate, incorporating an analysis of the quality of the studies available and the current understanding of the mode of action...
November 11, 2016: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/27833648/alternative-drugs-go-global-possible-lead-and-or-mercury-intoxication-from-imported-natural-health-products-and-a-need-for-scientifically-evaluated-poisoning-monitoring-from-environmental-exposures
#20
Lygia Therese Budnik, Xaver Baur, Volker Harth, Axel Hahn
BACKGROUND: With increases in globalization, cultural remedies from Chinese, Ayurvedic, Arab and other traditions have become more available to international consumers, offering unfamiliar "Natural Health Products" (NHP), used as alternative medicine or supplementary medicine. Contamination with toxic ingredients including lead, mercury, arsenic, and other toxic elements has been documented in several of these products from various parts of the globe, particularly from some parts of Asia and the Orient...
2016: Journal of Occupational Medicine and Toxicology
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