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Hormetics

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https://www.readbyqxmd.com/read/28916747/hormetic-potential-of-methylglyoxal-a-side-product-of-glycolysis-in-switching-tumours-from-growth-to-death
#1
Marie-Julie Nokin, Florence Durieux, Justine Bellier, Olivier Peulen, Koji Uchida, David A Spiegel, James R Cochrane, Craig A Hutton, Vincent Castronovo, Akeila Bellahcène
Metabolic reprogramming toward aerobic glycolysis unavoidably favours methylglyoxal (MG) and advanced glycation end products (AGEs) formation in cancer cells. MG was initially considered a highly cytotoxic molecule with potential anti-cancer value. However, we have recently demonstrated that MG enhanced tumour growth and metastasis. In an attempt to understand this dual role, we explored MG-mediated dicarbonyl stress status in four breast and glioblastoma cancer cell lines in relation with their glycolytic phenotype and MG detoxifying capacity...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28905473/does-multigenerational-exposure-to-hormetic-concentrations-of-imidacloprid-precondition-aphids-for-increased-insecticide-tolerance
#2
Rachel R Rix, G Christopher Cutler
BACKGROUND: Hormetic preconditioning, whereby exposure to mild stress primes an organism to better tolerate subsequent stress, is well documented. It is unknown if exposure to hormetic concentrations of insecticide can trans-generationally prime insects to better tolerate insecticide exposure, or whether exposure to hormetic concentrations of insecticide can induce mutations in genes responsible for insecticide resistance. Using the aphid Myzus persicae (Sulzer) and insecticide imidacloprid as a model, we examined if exposure to mildly toxic and hormetic concentrations of imidacloprid reduced aphid susceptibility to insecticides across four generations, and whether such exposures induced mutations in the imidacloprid binding site in post-synaptic nicotinic acetylcholine receptors...
September 14, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28899752/are-adult-life-history-traits-in-oriental-fruit-moth-affected-by-a-mild-pupal-heat-stress
#3
Jincheng Zheng, Xiongbin Cheng, Ary A Hoffmann, Bo Zhang, Chun-Sen Ma
Thermal stress at one life stage can affect fitness at a later stage in ectotherms with complex life cycles. Most relevant studies have focused on extreme stress levels, but here we also show substantial fitness effects in a moth when pupae are exposed to a relatively mild and sublethal heat stress. We consider the impact of a 35°C heat stress of 2h in three geographically separate populations of the oriental fruit moth (OFM, Grapholita molesta) from northern, middle and southern China. Heat stress negatively affected fecundity but increased adult heat resistance and adult longevity...
September 9, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28886567/expanding-the-application-scope-of-on-farm-biopurification-systems-effect-and-removal-of-oxytetracycline-in-a-biomixture
#4
David Jiménez-Gamboa, Víctor Castro-Gutiérrez, Ericka Fernández-Fernández, Susana Briceño-Guevara, Mario Masís-Mora, Juan Salvador Chin-Pampillo, Marielos Mora-López, Elizabeth Carazo-Rojas, Carlos E Rodríguez-Rodríguez
Antibiotic-containing wastewaters produced in agricultural activities may depress the pesticide-degrading capacity of biomixtures contained in biopurification systems. This work aimed to assay the effect of oxytetracycline (OTC) on the removal of carbofuran (CFN) in an optimized biomixture, and to determine the capacity of the system to dissipate OTC. During co-application of CFN+OTC, CFN removal and its accelerated degradation were not negatively affected. Similarly, different doses of OTC (10-500mgkg(-1)) did not significantly affect CFN mineralization, and the process even exhibited a hormetic-like effect...
August 26, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28881226/a-comparison-of-the-effects-of-copper-nanoparticles-and-copper-sulfate-on-phaeodactylum-tricornutum-physiology-and-transcription
#5
Youchao Zhu, Jiahui Xu, Tao Lu, Meng Zhang, Mingjing Ke, Zhengwei Fu, Xiangliang Pan, Haifeng Qian
Copper nanoparticles (CuNPs) have been used in a broad range of applications. However, they are inevitably released into the marine environment, making it necessary to evaluate their potential effects on marine phytoplankton. In this study, the short-term (96h) effects of CuNPs and CuSO4 on Phacodactylum tricornutum growth, photosynthesis, reactive oxygen species production and transcription were assessed. It was found that high concentrations (40μM) of CuNPs and CuSO4 significantly inhibited the growth, photosynthesis and induced oxidative stress of P...
August 31, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28858708/the-time-dependent-stimulation-of-sodium-halide-salts-on-redox-reactants-energy-supply-and-luminescence-in-vibrio-fischeri
#6
Zhenyang Yu, Jing Zhang, Meifang Hou
The excess of halide ions (F(-), Cl(-), Br(-), I(-)) can cause adverse effects. Earlier studies demonstrated time-dependent stimulations of organic salts with halide ions on photobacteria. Therefore, inorganic ones with halide ions (e.g., NaX, X=F(-), Cl(-), Br(-), I(-)) were assumed to cause similar effects. In the present study, Vibrio fischeri was exposed to NaX. Results showed that the contents of favin mono-nucleotide (FMN), nicotinamide adenine dinucleotide (NADH), and nicotinamide adenine dinucleotide phosphate (NADPH) were stimulated by NaX with a time-dependent fashion...
August 28, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28844286/metal-nanoparticle-induced-hormetic-activation-a-novel-mechanism-of-homeopathic-medicines
#7
Prashant S Chikramane, Akkihebbal K Suresh, Shantaram G Kane, Jayesh R Bellare
BACKGROUND: High-potency homeopathic remedies, 30c and 200c have enormous dilution factors of 10(60) and 10(400) respectively. Therefore, the presence of physical entities in them is inconceivable. As a result, their efficacy is highly debated and often dismissed as a placebo. Despite several hypotheses postulated to explain the claimed homeopathic efficacy, none have satisfactorily answered the qualms of the sceptics. Against all beliefs and principles of conventional dilution, we have shown that nanoparticles (NPs) of the starting metals are unequivocally found in the 30c and 200c remedies at concentrations of a few pg/ml...
August 2017: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/28825965/effects-of-intermitent-fasting-and-chronic-swimming-exercise-on-body-composition-and-lipid-metabolism
#8
Ruan Carlos Macêdo Moraes, Guilherme Vannucchi Portari, Alex Soares Marreiros Ferraz, Tiago Eugênio Oliveira Silva, Moacir Marocolo
Intermittent fasting protocol (IFP), has been suggested as a strategy to change body metabolism and improve health. The effects of IFP seem to be similar to aerobic exercise, having a hormetic adaptation according to intensity and frequency. However, the effects of combining both interventions are still unknown. Therefore, the aim of the present study was to evaluate the effects of IFP with and without endurance exercise training on body composition, food behavior, and lipid metabolism. Twenty weeks old Wistar rats were kept under an inverted circadian cycle of 12 hours with water ad libitum and assigned to four different groups: control group (CON; ad libitum feeding and sedentary); exercise group (EX; ad libitum feeding and endurance training); intermittent fasting group (IF; intermittent fasting and sedentary); intermittent fasting and exercise group (IFEX; intermittent fasting and endurance training)...
August 21, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28739146/relative-toxicological-ranking-of-eight-polybrominated-diphenyl-ether-congeners-using-cytotoxicity-chemical-properties-and-exposure-data
#9
Sabrina Tait, Monia Perugini, Cinzia La Rocca
Polybrominated diphenyl ethers are widely used flame retardants which persist and diffuse in the environment thus entering the food chain. Eight congeners, most relevant for human exposure (BDE-28, 47, 99, 100, 153, 154, 183 and 209), were analyzed in vitro and in silico to derive a relative toxicological ranking. Cytotoxicity was assessed on human liver (HepG2) and colon (DLD-1) cell lines, by three assays (MTS, ATP and DNA content) in a range of realistic concentration (1pM - 10 nM). Jejunum and Caco-2 passive absorptions were calculated in silico...
July 21, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28726184/hormetic-effect-of-triiodothyronine-in-metabolically-healthy-obese-persons
#10
Ji Eun Jun, Tae Hyuk Kim, Seung-Eun Lee, You-Bin Lee, Jae Hwan Jee, Ji Cheol Bae, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim, Sun Wook Kim, Jae Hoon Chung, Yong-Ki Min, Moon-Kyu Lee
PURPOSE: Metabolically healthy obese is the designation for a subgroup of obese individuals with normal metabolic features. However, metabolically healthy obese individuals are prone to developing metabolic syndrome. Serum triiodothyronine (T3) levels are associated with various metabolic risk factors including obesity. Therefore, this longitudinal study aimed to explore the possible correlation between serum T3 concentration and the onset of MetS in metabolically healthy obese persons...
July 19, 2017: Endocrine
https://www.readbyqxmd.com/read/28723568/loss-of-hepatic-mitochondrial-long-chain-fatty-acid-oxidation-confers-resistance-to-diet-induced-obesity-and-glucose-intolerance
#11
Jieun Lee, Joseph Choi, Ebru S Selen Alpergin, Liang Zhao, Thomas Hartung, Susanna Scafidi, Ryan C Riddle, Michael J Wolfgang
The liver has a large capacity for mitochondrial fatty acid β-oxidation, which is critical for systemic metabolic adaptations such as gluconeogenesis and ketogenesis. To understand the role of hepatic fatty acid oxidation in response to a chronic high-fat diet (HFD), we generated mice with a liver-specific deficiency of mitochondrial long-chain fatty acid β-oxidation (Cpt2(L-/-) mice). Paradoxically, Cpt2(L-/-) mice were resistant to HFD-induced obesity and glucose intolerance with an absence of liver damage, although they exhibited serum dyslipidemia, hepatic oxidative stress, and systemic carnitine deficiency...
July 18, 2017: Cell Reports
https://www.readbyqxmd.com/read/28717386/understanding-low-radiation-background-biology-through-controlled-evolution-experiments
#12
Nathanael Lampe, Vincent Breton, David Sarramia, Télesphore Sime-Ngando, David G Biron
Biological experiments conducted in underground laboratories over the last decade have shown that life can respond to relatively small changes in the radiation background in unconventional ways. Rapid changes in cell growth, indicative of hormetic behaviour and long-term inheritable changes in antioxidant regulation have been observed in response to changes in the radiation background that should be almost undetectable to cells. Here, we summarize the recent body of underground experiments conducted to date, and outline potential mechanisms (such as cell signalling, DNA repair and antioxidant regulation) that could mediate the response of cells to low radiation backgrounds...
August 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28715457/an-analogous-wood-barrel-theory-to-explain-the-occurrence-of-hormesis-a-case-study-of-sulfonamides-and-erythromycin-on-escherichia-coli-growth
#13
Dali Wang, Zhifen Lin, Ting Wang, Xiruo Ding, Ying Liu
Hormesis has aroused much attention during the past two decades and may have great implications on many fields, including toxicology and risk assessment. However, the observation of hormesis remains challenged under laboratory conditions. To determine favorable conditions under which to observe hormesis, we investigated the hormetic responses of Escherichia coli (E. coli) upon exposure of different concentrations of sulfonamides and erythromycin at different time points and in different culture media: Luria-Bertani (LB) broth and Mueller Hinton (MH) broth...
2017: PloS One
https://www.readbyqxmd.com/read/28699353/radiation-hormesis-the-link-to-nanomolar-hydrogen-peroxide
#14
Helmut Sies, Ludwig E Feinendegen
Hydrogen peroxide (H2O2) is a stable product of water radiolysis, occurring at nanomolar concentration upon low-dose ionizing radiation (LDIR) (<100 mGy). In view of the recent recognition of H2O2 as a central redox signaling molecule that, likewise, is maintained in the nanomolar range in cells, we propose a role for H2O2 in radiation hormesis. LDIR is capable of utilizing known molecular redox master switches such as Nrf2/Keap1 or NF-κB/IκB to effect adaptive resistance. This leads to the hypothesis that, as a normal component of the exposome, LDIR mediates hormetic effects by H2O2 signaling...
August 7, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28685176/the-hormetic-functions-of-wnt-pathways-in-tubular-injury
#15
REVIEW
Elisabeth F Gröne, Giuseppina Federico, Peter J Nelson, Bernd Arnold, Hermann-Josef Gröne
Chronic tubulointerstitial damage with tubular epithelial atrophy and interstitial fibrosis is the hallmark of chronic kidney disease (CKD) and a predictor for progression of CKD.Several experiments have now provided evidence that the Wnt signaling pathways are significantly contributing to atrophy and fibrosis; in contrast, it also has been shown that the Wnt system fosters regenerative processes in acute tubular injury.We now have demonstrated that Dickkopf 3 (DKK3) is an agonist for canonical Wnt signaling in CKD and fosters chronic fibrosing inflammation of the tubulointerstitial compartment...
August 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28624671/radiation-exposure-of-barley-seeds-can-modify-the-early-stages-of-plants-development
#16
Stanislav Geras'kin, Roman Churyukin, Polina Volkova
The reactions of barley seeds (Nur and Grace varieties) in terms of the root and sprout lengths, germination and root mass were studied after γ-irradiation with doses in the range of 2-50 Gy. The dose range in which plants' growth stimulation occurs (16-20 Gy) was identified. It was shown that increased size of seedlings after irradiation with stimulating doses was due to the enhancing pace of development rather than an earlier germination. The activity of the majority of the enzymes studied increased in the range of doses that cause stimulation of seedlings development...
October 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28624355/3-np-induced-huntington-s-like-disease-impairs-nrf2-activation-without-loss-of-cardiac-function-in-aged-rats
#17
A Silva-Palacios, M Ostolga-Chavarría, M Buelna-Chontal, C Garibay, S Hernández-Reséndiz, F J Roldán, P L Flores, A Luna-López, M Königsberg, C Zazueta
Cardiovascular diseases (CVDs) are one of the leading causes of death in patients over 60years with Huntington's disease (HD). Here, we investigated if age-related oxidative stress (OS) is a relevant factor to develop cardiac damage in an in vivo model of striatal neurodegeneration induced by 3-nitropropionic acid (3-NP). We also evaluated the potential effect of tert-butylhydroquinone (tBHQ) to increase the Nrf2-regulated antioxidant response in hearts from adult and aged rats intoxicated with 3-NP. Our results showed that 3-NP-treatment did not induce cardiac dysfunction, neither in adult nor in aged rats...
June 15, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28622829/investigation-of-j-shaped-dose-responses-induced-by-exposure-to-the-alkylating-agent-n-methyl-n-nitrosourea
#18
Katherine E Chapman, George R Hoffmann, Shareen H Doak, Gareth J S Jenkins
Hormesis is defined as a biphasic dose-response where biological effects of low doses of a stressor demonstrate the opposite effect to high-dose effects of the same stressor. Hormetic, or J-shaped, dose-response relationships are relatively rarely observed in toxicology, resulting in a limited understanding and even some skepticism of the concept. Low dose-response studies for genotoxicity endpoints have been performed at Swansea University for over a decade. However, no statistically significant decreases below control genotoxicity levels have been detected until recently...
July 2017: Mutation Research
https://www.readbyqxmd.com/read/28595318/mediterranean-diet-and-inflammaging-within-the-hormesis-paradigm
#19
Morena Martucci, Rita Ostan, Fiammetta Biondi, Elena Bellavista, Cristina Fabbri, Claudia Bertarelli, Stefano Salvioli, Miriam Capri, Claudio Franceschi, Aurelia Santoro
A coherent set of epidemiological data shows that the Mediterranean diet has beneficial effects capable of preventing a variety of age-related diseases in which low-grade, chronic inflammation/inflammaging plays a major role, but the underpinning mechanism(s) is/are still unclear. It is argued here that the Mediterranean diet can be conceptualized as a form of chronic hormetic stress, similar to what has been proposed regarding calorie restriction, the most thoroughly studied nutritional intervention. Data on the presence in key Mediterranean foods of a variety of compounds capable of exerting hormetic effects are summarized, and the mechanistic role of the nuclear factor erythroid 2 pathway is highlighted...
June 8, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28586505/cellular-stress-response-mechanisms-as-therapeutic-targets-of-ginsenosides
#20
REVIEW
Hong-Yi Qi, Li Li, Hui Ma
Ginseng, one of the most widely used traditional herbal medicines and dietary supplements, has historically been recognized as a tonic herb and adaptogen that can enhance the body's tolerance to various adversities. Ginsenosides are a diverse group of steroidal saponins that comprise the major secondary metabolites of ginseng and are responsible for its multiple pharmacological effects. Emerging evidence suggests that hormetic phytochemicals produced by environmentally stressed plants can activate the moderate cellular stress response mechanisms at a subtoxic level in humans, which may enhance tolerance against severe dysfunction or disease...
June 6, 2017: Medicinal Research Reviews
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