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Hormetics

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https://www.readbyqxmd.com/read/27898662/kinase-inhibition-leads-to-hormesis-in-a-dual-phosphorylation-dephosphorylation-cycle
#1
Peter Rashkov, Ian P Barrett, Robert E Beardmore, Claus Bendtsen, Ivana Gudelj
Many antimicrobial and anti-tumour drugs elicit hormetic responses characterised by low-dose stimulation and high-dose inhibition. While this can have profound consequences for human health, with low drug concentrations actually stimulating pathogen or tumour growth, the mechanistic understanding behind such responses is still lacking. We propose a novel, simple but general mechanism that could give rise to hormesis in systems where an inhibitor acts on an enzyme. At its core is one of the basic building blocks in intracellular signalling, the dual phosphorylation-dephosphorylation motif, found in diverse regulatory processes including control of cell proliferation and programmed cell death...
November 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27898171/hormesis-cellular-stress-response-and-neuroinflammation-in-schizophrenia-early-onset-versus-late-onset-state
#2
REVIEW
Vittorio Calabrese, James Giordano, Rosalia Crupi, Rosanna Di Paola, Martino Ruggieri, Rio Bianchini, Maria Laura Ontario, Salvatore Cuzzocrea, Edward J Calabrese
Abnormal redox homeostasis and oxidative stress have been proposed to play a role in the etiology of several neuropsychiatric spectrum disorders. Emerging interest has recently focused on markers of oxidative stress and neuroinflammation in schizophrenic spectrum disorders, at least in particular subgroups of patients. Altered expression of genes related to oxidative stress, oxidative damage to DNA, protein and lipids, as well as reduced glutathione levels in central and peripheral tissues could act synergistically, and contribute to the course of the disease...
November 29, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27862176/inflammasomes-hormesis-and-antioxidants-in-neuroinflammation-role-of-nrlp3-in-alzheimer-disease
#3
REVIEW
Manuela Pennisi, Rosalia Crupi, Rosanna Di Paola, Maria Laura Ontario, Rita Bella, Edward J Calabrese, Roberto Crea, Salvatore Cuzzocrea, Vittorio Calabrese
Alzheimer disease (AD) is a progressive neurodegenerative disorder leading to cognitive decline, neuropsychiatric symptoms, disability, caregiver burden, and premature death. It represents the most prevalent cause of dementia, and its incidence rates exponentially increase with increasing age. The number of Americans living with AD is rapidly increasing. An estimated 5.4 million Americans of all ages have AD in 2016. One in nine people aged 65 and older has AD, and by midcentury, someone in the United States will develop the disease every 33 sec...
November 8, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27853721/look-different-effect-of-radiation-hormesis-on-the-survival-rate-of-immunosuppressed-mice
#4
M Alavi, S Taeb, M A Okhovat, M Atefi, F Negahdari
BACKGROUND: Hormesis is defined as the bio-positive response of something which is bio-negative in high doses. In the present study, the effect of radiation hormesis was evaluated on the survival rate of immunosuppressed BALB/c mice by Cyclosporine A. MATERIAL AND METHODS: We used 75 consanguine, male, BALB/c mice in this experiment. The first group received Technetium-99m and the second group was placed on a sample radioactive soil of Ramsar region (800Bq) for 20 days...
September 2016: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/27835779/berberine-protects-against-6-ohda-induced-neurotoxicity-in-pc12-cells-and-zebrafish-through-hormetic-mechanisms-involving-pi3k-akt-bcl-2-and-nrf2-ho-1-pathways
#5
Chao Zhang, Chuwen Li, Shenghui Chen, Zhiping Li, Xuejing Jia, Kai Wang, Jiaolin Bao, Yeer Liang, Xiaotong Wang, Meiwan Chen, Peng Li, Huanxing Su, Jian-Bo Wan, Simon Ming Yuen Lee, Kechun Liu, Chengwei He
Berberine (BBR) is a renowned natural compound that exhibits potent neuroprotective activities. However, the cellular and molecular mechanisms are still unclear. Hormesis is an adaptive mechanism generally activated by mild oxidative stress to protect the cells from further damage. Many phytochemicals have been shown to induce hormesis. This study aims to investigate whether the neuroprotective activity of BBR is mediated by hormesis and the related signaling pathways in 6-OHDA-induced PC12 cells and zebrafish neurotoxic models...
November 4, 2016: Redox Biology
https://www.readbyqxmd.com/read/27813595/antioxidant-activity-anti-proliferative-activity-and-amino-acid-profiles-of-ethanolic-extracts-of-edible-mushrooms
#6
S Panthong, N Boonsathorn, S Chuchawankul
Biological activities of various mushrooms have recently been discovered, particularly, immunomodulatory and antitumor activities. Herein, three edible mushrooms, Auricularia auricula-judae (AA), Pleurotus abalonus (PA) and Pleurotus sajor-caju (PS) extracted using Soxhlet ethanol extraction were evaluated for their antioxidative, anti-proliferative effects on leukemia cells. Using the Folin-Ciocalteau method and Trolox equivalent antioxidant capacity assay, phenolics and antioxidant activity were found in all sample mushrooms...
October 17, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27777382/prenatal-hyperbaric-normoxia-treatment-improves-healthspan-and-regulates-chitin-metabolic-genes-in-drosophila-melanogaster
#7
Suyeun Yu, Eunil Lee, Bodokhsuren Tsogbadrakh, Gwang-Ic Son, Mari Kim
Aging is a universal, irreversible process accompanied by physiological declines that culminate in death. Rapid progress in gerontology research has revealed that aging can be slowed through mild stress-induced hormesis. We previously reported that hyperbaric normoxia (HN, 2 atm absolute pressure with 10% O2) induces a cytoprotective response in vitro by regulating fibronectin. In the present study, we investigated the hormetic effects of prenatal HN exposure on Drosophila healthspan related to molecular defense mechanisms...
October 24, 2016: Aging
https://www.readbyqxmd.com/read/27776852/hormetic-effects-of-metal-ions-upon-v-fischeri-and-the-application-of-a-new-parameter-for-the-quantitative-assessment-of-hormesis
#8
Xiaoming Zou, Xiaoyu Xiao, Yu He, Lijun Hu, Cui Hu, Xiangfeng Huang
Hormesis is an intriguing phenomenon that is characterized by low dose stimulation and high dose inhibition. Several traditional parameters, such as the concentration of the zero equivalent point (ZEP) and the maximal stimulatory effect (Ymax), have been used to characterize the zone of hormesis or the extent of the stimulatory effect. However, the characteristics of hormesis for chemicals cannot be quantified completely by one parameter, which is important to accurately compare the hormetic effects of chemicals and to describe the combined effects of chemical mixtures at low doses...
September 20, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27768859/4-hydroxyalkenal-activated-ppar%C3%AE-mediates-hormetic-interactions-in-diabetes
#9
Shlomo Sasson
Activated peroxisome proliferator-activated receptor-δ (PPARδ) induces the expression of genes encoding enzymes that metabolize fatty acids and carbohydrate. Attempts to identify cellular activators of PPARδ produced large lists of various fatty acids and their metabolic derivatives; however, there is no consensus on specific and selective binding interactions of natural ligands with PPARδ. Most models on binding interactions within the ligand binding domain (LBD) of PPARδ have been derived from analyses of PPARδ-LBD crystals formed with synthetic low molecular weight ligands...
October 18, 2016: Biochimie
https://www.readbyqxmd.com/read/27765347/neurohormetic-responses-of-quercetin-and-rutin-in-a-cell-line-over-expressing-the-amyloid-precursor-protein-appswe-cells
#10
Sagrario Martín-Aragón, Karim Lizeth Jiménez-Aliaga, Juana Benedí, Paloma Bermejo-Bescós
BACKGROUND: Plant secondary metabolites may induce adaptive cellular stress-responses in a variety of cells including neurons at the sub-toxic doses ingested by humans. Such 'neurohormesis' phenomenon, activated by flavonoids such as quercetin or rutin, may involve cell responses driven by modulation of signaling pathways which are responsible for its neuroprotective effects. PURPOSE: We attempt to explore the molecular mechanisms involved in the neurohormetic responses to quercetin and rutin exposure, in a SH-SY5Y cell line which stably overexpresses the amyloid precursor protein (APP) Swedish mutation, based on a biphasic concentration-response relationship for cell viability...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27752524/transcriptomic-data-analysis-and-differential-gene-expression-of-antioxidant-pathways-in-king-penguin-juveniles-aptenodytes-patagonicus-before-and-after-acclimatization-to-marine-life
#11
Benjamin Rey, Cyril Dégletagne, Claude Duchamp
In this article, we present differentially expressed gene profiles in the pectoralis muscle of wild juvenile king penguins that were either naturally acclimated to cold marine environment or experimentally immersed in cold water as compared with penguin juveniles that never experienced cold water immersion. Transcriptomic data were obtained by hybridizing penguins total cDNA on Affymetrix GeneChip Chicken Genome arrays and analyzed using maxRS algorithm, "Transcriptome analysis in non-model species: a new method for the analysis of heterologous hybridization on microarrays" (Dégletagne et al...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27704189/sublethal-effects-of-chlorine-free-kraft-mill-effluents-on-daphnia-magna
#12
Soledad Chamorro, Daniela López, Pablina Brito, Mayra Jarpa, Benjamin Piña, Gladys Vidal
The implementation of elemental chlorine-free (ECF) bleaching methods has drastically reduced the aquatic toxicity of Kraft mill effluents during the last decade. However, the residual toxicity of Kraft mill effluents is still a potential concern for the environment, even when subjected to secondary wastewater treatment. The aim of this study is characterize potential sublethal effects of ECF Kraft mill effluents using Daphnia magna as model species. D. magna exposed towards increasing concentration of ECF Kraft mill effluent showed a significant, dose-dependent reduction in feeding...
December 2016: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27699197/data-of-oxygen-and-ph-dependent-oxidation-of-resveratrol
#13
Annabell Plauth, Anne Geikowski, Susanne Cichon, Sylvia J Wowro, Linda Liedgens, Morten Rousseau, Christopher Weidner, Luise Fuhr, Magdalena Kliem, Gail Jenkins, Silvina Lotito, Linda J Wainwright, Sascha Sauer
We show here if under physiologically relevant conditions resveratrol (RSV) remains stable or not. We further show under which circumstances various oxidation products of RSV such as ROS can be produced. For example, in addition to the widely known effect of bicarbonate ions, high pH values promote the decay of RSV. Moreover, we analyse the impact of reduction of the oxygen partial pressure on the pH-dependent oxidation of RSV. For further interpretation and discussion of these focused data in a broader context we refer to the article "Hormetic shifting of redox environment by pro-oxidative resveratrol protects cells against stress" (Plauth et al...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27696408/widespread-brain-transcriptome-alterations-underlie-the-neuroprotective-actions-of-dietary-saffron
#14
Nicholas V Skladnev, Varshika Ganeshan, Ji Yeon Kim, Thomas J Burton, John Mitrofanis, Jonathan Stone, Daniel M Johnstone
Dietary saffron has shown promise as a neuroprotective intervention in clinical trials of retinal degeneration and dementia and in animal models of multiple CNS disorders, including Parkinson's disease. This therapeutic potential makes it important to define the relationship between dose and protection and the mechanisms involved. To explore these two issues, mice were pre-conditioned by providing an aqueous extract of saffron (0.01% w/v) as their drinking water for 2, 5 or 10 days before administration of the parkinsonian neurotoxin MPTP (50 mg/kg)...
October 1, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27690013/time-in-redox-adaptation-processes-from-evolution-to-hormesis
#15
Mireille M J P E Sthijns, Antje R Weseler, Aalt Bast, Guido R M M Haenen
Life on Earth has to adapt to the ever changing environment. For example, due to introduction of oxygen in the atmosphere, an antioxidant network evolved to cope with the exposure to oxygen. The adaptive mechanisms of the antioxidant network, specifically the glutathione (GSH) system, are reviewed with a special focus on the time. The quickest adaptive response to oxidative stress is direct enzyme modification, increasing the GSH levels or activating the GSH-dependent protective enzymes. After several hours, a hormetic response is seen at the transcriptional level by up-regulating Nrf2-mediated expression of enzymes involved in GSH synthesis...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27689984/flavonoid-interaction-with-a-chitinase-from-grape-berry-skin-protein-identification-and-modulation-of-the-enzymatic-activity
#16
Antonio Filippi, Elisa Petrussa, Uros Rajcevic, Vladka Čurin Šerbec, Sabina Passamonti, Giovanni Renzone, Andrea Scaloni, Marco Zancani, Angelo Vianello, Enrico Braidot
In the present study, an antibody raised against a peptide sequence of rat bilitranslocase (anti-peptide Ab) was tested on microsomal proteins obtained from red grape berry skin. Previously, this antibody had demonstrated to recognize plant membrane proteins associated with flavonoid binding and transport. Immuno-proteomic assays identified a number of proteins reacting with this particular antibody, suggesting that the flavonoid binding and interaction may be extended not only to carriers of these molecules, but also to enzymes with very different functions...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27681420/discovery-and-function-of-a-general-core-hormetic-stress-response-in-e-%C3%A2-coli-induced-by-sublethal-concentrations-of-antibiotics
#17
Aurélie Mathieu, Sébastien Fleurier, Antoine Frénoy, Julien Dairou, Marie-Florence Bredeche, Pilar Sanchez-Vizuete, Xiaohu Song, Ivan Matic
A better understanding of the impact of antibiotics on bacteria is required to increase the efficiency of antibiotic treatments and to slow the emergence of resistance. Using Escherichia coli, we examined how bacteria exposed to sublethal concentrations of ampicillin adjust gene expression patterns and metabolism to simultaneously deal with the antibiotic-induced damage and maintain rapid growth. We found that the treated cells increased energy production, as well as translation and macromolecular repair and protection...
September 27, 2016: Cell Reports
https://www.readbyqxmd.com/read/27662637/major-pathogenic-mechanisms-in-vascular-dementia-roles-of-cellular-stress-response-and-hormesis-in-neuroprotection
#18
Vittorio Calabrese, James Giordano, Anna Signorile, Maria Laura Ontario, Sergio Castorina, Concetta De Pasquale, Gunter Eckert, Edward J Calabrese
Vascular dementia (VaD), considered the second most common cause of cognitive impairment after Alzheimer disease in the elderly, involves the impairment of memory and cognitive function as a consequence of cerebrovascular disease. Chronic cerebral hypoperfusion is a common pathophysiological condition frequently occurring in VaD. It is generally associated with neurovascular degeneration, in which neuronal damage and blood-brain barrier alterations coexist and evoke beta-amyloid-induced oxidative and nitrosative stress, mitochondrial dysfunction, and inflammasome- promoted neuroinflammation, which contribute to and exacerbate the course of disease...
December 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27644411/mechanism-underlying-time-dependent-cross-phenomenon-between-concentration-response-curves-and-concentration-addition-curves-a-case-study-of-sulfonamides-erythromycin-mixtures-on-escherichia-coli
#19
Haoyu Sun, Hongming Ge, Min Zheng, Zhifen Lin, Ying Liu
Previous studies have identified a phenomenon in which the concentration-response curves (CRCs) for mixtures cross the curves for concentration addition model when predicting or judging joint toxic actions. However, mechanistic investigations of this phenomenon are extremely limited. In this study, a similar phenomenon was observed when we determined the joint toxic actions of sulfonamides (SAs) and erythromycin (ERY) on Escherichia coli (E. coli), which we named the "cross-phenomenon", and it was characterized by antagonism in the low-concentration range, addition in the medium-concentration range, and synergism in the high-concentration range...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27642708/hormesis-cellular-stress-response-and-redox-homeostasis-in-autism-spectrum-disorders
#20
V Calabrese, J Giordano, M Ruggieri, D Berritta, A Trovato, M L Ontario, R Bianchini, E J Calabrese
In the United States, 1.1-1.5% of children have been diagnosed with autism spectrum disorders (ASD), corresponding to a 30% increase in incidence and prevalence. Social and communication impairments are the main signs and symptoms of ASD, and currently available medications have been ineffective in reducing these core deficits. Observational studies have indicated that children with ASD tend to show improved cognition and behavior after febrile illness, which is associated with alteration of metabolic pathways, leading to cellular stress responses and increased expression of heat shock proteins (Hsps)...
December 2016: Journal of Neuroscience Research
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