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Hormetics

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https://www.readbyqxmd.com/read/28624671/radiation-exposure-of-barley-seeds-can-modify-the-early-stages-of-plants-development
#1
Stanislav Geras'kin, Roman Churyukin, Polina Volkova
The reactions of barley seeds (Nur and Grace varieties) in terms of the root and sprout lengths, germination and root mass were studied after γ-irradiation with doses in the range of 2-50 Gy. The dose range in which plants' growth stimulation occurs (16-20 Gy) was identified. It was shown that increased size of seedlings after irradiation with stimulating doses was due to the enhancing pace of development rather than an earlier germination. The activity of the majority of the enzymes studied increased in the range of doses that cause stimulation of seedlings development...
June 15, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28624355/3-np-induced-huntington-s-like-disease-impairs-nrf2-activation-without-loss-of-cardiac-function-in-aged-rats
#2
A Silva-Palacios, M Ostolga-Chavarría, M Buelna-Chontal, C Garibay, S Hernández-Reséndiz, F J Roldán, P L Flores, A Luna-López, M Königsberg, C Zazueta
Cardiovascular diseases (CVDs) are one of the leading causes of death in patients over 60years with Huntington's disease (HD). Here, we investigated if age-related oxidative stress (OS) is a relevant factor to develop cardiac damage in an in vivo model of striatal neurodegeneration induced by 3-nitropropionic acid (3-NP). We also evaluated the potential effect of tert-butylhydroquinone (tBHQ) to increase the Nrf2-regulated antioxidant response in hearts from adult and aged rats intoxicated with 3-NP. Our results showed that 3-NP-treatment did not induce cardiac dysfunction, neither in adult nor in aged rats...
June 14, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28622829/investigation-of-j-shaped-dose-responses-induced-by-exposure-to-the-alkylating-agent-n-methyl-n-nitrosourea
#3
Katherine E Chapman, George R Hoffmann, Shareen H Doak, Gareth J S Jenkins
Hormesis is defined as a biphasic dose-response where biological effects of low doses of a stressor demonstrate the opposite effect to high-dose effects of the same stressor. Hormetic, or J-shaped, dose-response relationships are relatively rarely observed in toxicology, resulting in a limited understanding and even some skepticism of the concept. Low dose-response studies for genotoxicity endpoints have been performed at Swansea University for over a decade. However, no statistically significant decreases below control genotoxicity levels have been detected until recently...
July 2017: Mutation Research
https://www.readbyqxmd.com/read/28595318/mediterranean-diet-and-inflammaging-within-the-hormesis-paradigm
#4
Morena Martucci, Rita Ostan, Fiammetta Biondi, Elena Bellavista, Cristina Fabbri, Claudia Bertarelli, Stefano Salvioli, Miriam Capri, Claudio Franceschi, Aurelia Santoro
A coherent set of epidemiological data shows that the Mediterranean diet has beneficial effects capable of preventing a variety of age-related diseases in which low-grade, chronic inflammation/inflammaging plays a major role, but the underpinning mechanism(s) is/are still unclear. It is argued here that the Mediterranean diet can be conceptualized as a form of chronic hormetic stress, similar to what has been proposed regarding calorie restriction, the most thoroughly studied nutritional intervention. Data on the presence in key Mediterranean foods of a variety of compounds capable of exerting hormetic effects are summarized, and the mechanistic role of the nuclear factor erythroid 2 pathway is highlighted...
June 8, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28586505/cellular-stress-response-mechanisms-as-therapeutic-targets-of-ginsenosides
#5
REVIEW
Hong-Yi Qi, Li Li, Hui Ma
Ginseng, one of the most widely used traditional herbal medicines and dietary supplements, has historically been recognized as a tonic herb and adaptogen that can enhance the body's tolerance to various adversities. Ginsenosides are a diverse group of steroidal saponins that comprise the major secondary metabolites of ginseng and are responsible for its multiple pharmacological effects. Emerging evidence suggests that hormetic phytochemicals produced by environmentally stressed plants can activate the moderate cellular stress response mechanisms at a subtoxic level in humans, which may enhance tolerance against severe dysfunction or disease...
June 6, 2017: Medicinal Research Reviews
https://www.readbyqxmd.com/read/28577963/physiological-and-pathological-processes-of-synaptic-plasticity-and-memory-in-drug-discovery-do-not-forget-the-dose-response-curve
#6
Jos Prickaerts, Nick P Van Goethem, Walter Gulisano, Elentina K Argyrousi, Agostino Palmeri, Daniela Puzzo
The response of a biological system to an endogenous or exogenous molecule depends upon the dose. For this reason, performing dose-response curves is crucial to understand physiological and pathophysiological phenomena, and to predict the effect of a drug. Most of the studies in pharmacological research have been performed according to the classical threshold model, focusing on higher doses able to ensure a biological effect. However, recent evidences pointed out the need to investigate the effect of low doses...
May 31, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28560625/fullerol-c60-oh-24-nanoparticles-and-mycotoxigenic-fungi-a-preliminary-investigation-into-modulation-of-mycotoxin-production
#7
Tihomir Kovač, Bojan Šarkanj, Tomislav Klapec, Ivana Borišev, Marija Kovač, Ante Nevistić, Ivica Strelec
Increased use of fullerols in various fields and expected increase of their environmental spread impose the necessity for testing fullerol nanoparticles (FNP) effects on microbiota. There is little information available on the interaction of mycotoxigenic fungi and FNP, despite FNP having a great potential of modifying mycotoxin production. Namely, FNP exhibit both ROS-quenching and ROS-producing properties, while oxidative stress stimulates mycotoxin synthesis in the fungi. In order to shed some light on the extent of interaction between FNP and mycotoxigenic fungi, the effects of fullerol C60(OH)24 nanoparticles (10, 100, 1000 ng/mL) on mycelial growth, aflatoxin production and oxidative stress modulation in an aflatoxigenic strain of Aspergillus flavus (NRRL 3251) during 168 h of incubation in a liquid culture medium were examined...
May 30, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28558431/physiological-and-biochemical-effects-of-nanoparticulate-copper-bulk-copper-copper-chloride-and-kinetin-in-kidney-bean-phaseolus-vulgaris-plants
#8
Suzanne A Apodaca, Wenjuan Tan, Osvaldo E Dominguez, Jose A Hernandez-Viezcas, Jose R Peralta-Videa, Jorge L Gardea-Torresdey
It is essential to understand the interactions of engineered nanoparticles (ENPs) with additives used in agriculture and their impacts on crop plants. In this study, kidney bean (Phaseolus vulgaris) plants were grown in potting soil amended with either nano copper (nCu), bulk copper (bCu), or copper chloride (CuCl2) at 0, 50, and 100mg/kg, combined with 0, 10, or 100μM of kinetin (KN). Plant growth, Cu, micro and macroelement concentrations, chlorophyll content, and enzymatic activity were examined in 55-day old plants...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28534811/hormetic-property-of-ginseng-steroids-on-anti-oxidant-status-against-exercise-challenge-in-rat-skeletal-muscle
#9
Ming-Fen Hsu, Szu-Hsien Yu, Mallikarjuna Korivi, Wei-Horng Jean, Shin-Da Lee, Chih-Yang Huang, Yi-Hung Liao, Jessica Lu, Chia-Hua Kuo
BACKGROUND: Existing literature on anti-oxidant capacity of ginseng has been inconsistent due to variance in the profile of ginseng steroids (Ginsenosides) that is because of differences in seasons and species. METHODS: We used various doses of ginseng steroids to determine its effect on oxidative stress and anti-oxidant capacity of rat skeletal muscle against exercise. RESULTS: Under non-exercise conditions, we found increased thiobarbituric acid reactive substance (TBARS) levels and decreased reduced/oxidized glutathione ratio (GSH/GSSG) in rat skeletal muscle as dose increases (p < 0...
May 19, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28520791/toxic-and-hormetic-like-effects-of-three-components-of-citrus-essential-oils-on-adult-mediterranean-fruit-flies-ceratitis-capitata
#10
Stella A Papanastasiou, Eleftheria-Maria D Bali, Charalampos S Ioannou, Dimitrios P Papachristos, Kostas D Zarpas, Nikos T Papadopoulos
Plant essential oils (EOs) and a wide range of their individual components are involved in a variety of biological interactions with insect pests including stimulatory, deterrent, toxic and even hormetic effects. Both the beneficial and toxic properties of citrus EOs on the Mediterranean fruit fly (medfly) have been experimentally evidenced over the last years. However, no information is available regarding the toxic or beneficial effects of the major components of citrus EOs via contact with the adults of the Mediterranean fruit fly...
2017: PloS One
https://www.readbyqxmd.com/read/28507194/molecular-basis-of-exercise-induced-skeletal-muscle-mitochondrial-biogenesis-historical-advances-current-knowledge-and-future-challenges
#11
Christopher G R Perry, John A Hawley
We provide an overview of groundbreaking studies that laid the foundation for our current understanding of exercise-induced mitochondrial biogenesis and its contribution to human skeletal muscle fitness. We highlight the mechanisms by which skeletal muscle responds to the acute perturbations in cellular energy homeostasis evoked by a single bout of endurance-based exercise and the adaptations resulting from the repeated demands of exercise training that ultimately promote mitochondrial biogenesis through hormetic feedback loops...
May 15, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28485107/low-doses-of-glyphosate-enhance-growth-co2-assimilation-stomatal-conductance-and-transpiration-in-sugarcane-and-eucalyptus
#12
Renan F Nascentes, Caio A Carbonari, Plinio S Simões, Marcela C Brunelli, Edivaldo D Velini, Stephen O Duke
INTRODUCTION: Sublethal doses of herbicides can enhance plant growth and stimulate other process, an effect known as hormesis. The magnitude of hormesis is dependent on the plant species, the herbicide and its dose, plant development stage, and environmental parameters. Glyphosate hormesis is well established, but relatively little is known of the mechanism of this phenomenon. The objective of this study was to determine if low doses of glyphosate that cause growth stimulation in sugarcane and eucalyptus concomitantly stimulate CO2 assimilation...
May 9, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28474024/enhanced-photo-responsiveness-in-a-photoswitchable-system-model-emergent-hormetic-catalysis
#13
J-C Micheau, C Coudret
Michaelis Menten catalysis by a T-photochromic system has been analyzed numerically. Using an appropriate set of rate constants and quantum yields, we have evidenced an enhanced photo-responsiveness at a medium light intensity: the plot of the initial rate vs. light intensity is bell-shaped. This emergent phenomenon can be qualified as hormetic catalysis. The analysis of the chemical flows shows that a directional rotation occurs within the cyclic scheme. Non equilibrium conditions are provided by two independent sources: the chemical energy dissipation from the irreversible exergonic reaction and the steady transformation of light into heat by T-photochromism...
May 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28439921/impact-of-obstructive-sleep-apnoea-and-intermittent-hypoxia-on-cardiovascular-and-cerebrovascular-regulation
#14
Andrew E Beaudin, Xavier Waltz, Patrick J Hanly, Marc J Poulin
Obstructive sleep apnoea (OSA) is associated with increased risk of cardiovascular and cerebrovascular disease, a consequence attributed in part to chronic intermittent hypoxia (IH) resulting from repetitive apnoeas during sleep. Although findings from experimental animal, and human, models have shown that IH is detrimental to vascular regulation, the severity of IH used in many of these animal studies (e.g. inspired fraction of oxygen (FI O2 ) = 2-3%; oxygen desaturation index (ODI) = 120 events h(-1) ) is considerably greater than that observed in the majority of patients with OSA...
April 24, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28418333/nonlinear-feedback-drives-homeostatic-plasticity-in-h2o2-stress-response
#15
Youlian Goulev, Sandrine Morlot, Audrey Matifas, Bo Huang, Mikael Molin, Michel B Toledano, Gilles Charvin
Homeostatic systems that rely on genetic regulatory networks are intrinsically limited by the transcriptional response time, which may restrict a cell's ability to adapt to unanticipated environmental challenges. To bypass this limitation, cells have evolved mechanisms whereby exposure to mild stress increases their resistance to subsequent threats. However, the mechanisms responsible for such adaptive homeostasis remain largely unknown. Here, we used live-cell imaging and microfluidics to investigate the adaptive response of budding yeast to temporally controlled H2O2 stress patterns...
April 18, 2017: ELife
https://www.readbyqxmd.com/read/28412924/neurons-vs-germline-a-war-of-hormetic-tradeoffs
#16
Marios Kyriazis
The process of human ageing is significantly dependent upon events which are currently shaping humanity. One such event is the seemingly inexorable progress of technology, and specifically, digital communications technology. Technology and biology are tightly interconnected, and this has a direct relevance on how our own ageing mechanisms are evolving and adapting to the change. One way technology may affect biological ageing is based on the concept of information exposure which acts as a hormetic stimulus and up-regulates neuronal stress response pathways...
April 13, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28409426/ethylenediurea-as-a-potential-tool-in-evaluating-ozone-phytotoxicity-a-review-study-on-physiological-biochemical-and-morphological-responses-of-plants
#17
Supriya Tiwari
Present-day climate change scenario has intensified the problem of continuously increasing ground-level ozone (O3), which is responsible for causing deleterious effects on growth and development of plants. Studies involving use of ethylenediurea (EDU), a chemical with antiozonant properties, have given some promising results in evaluating O3 injury in plants. The use of EDU is especially advantageous in developing countries which face a more severe problem of ground-level O3, and technical O3-induced yield loss assessment techniques like open-top chambers cannot be used...
April 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28407662/effects-of-a-one-week-fasting-therapy-in-patients-with-type-2-diabetes-mellitus-and-metabolic-syndrome-a-randomized-controlled-explorative-study
#18
Chenying Li, Badri Sadraie, Nico Steckhan, Christian Kessler, Rainer Stange, Michael Jeitler, Andreas Michalsen
There is increasing experimental evidence for beneficial effects of calorie restriction and intermittent fasting in type 2 diabetes mellitus (T2DM). In humans, prolonged fasting is established as a health-promoting complementary treatment in Europe and claimed to improve metabolism by a complex hormetic response. We aimed to investigate effects of a one-week fasting period compared to usual care in T2DM by means of a pilot trial. Patients with manifest T2DM medically treated with oral hypoglycemic agents and/or insulin were randomly assigned to a 7-day fasting program followed by dietary advice or to usual care and dietary advice only...
April 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28391182/tert-buthylhydroquinone-pre-conditioning-exerts-dual-effects-in-old-female-rats-exposed-to-3-nitropropionic-acid
#19
Alejandro Silva-Palacios, Ana L Colín-González, Stefanie P López-Cervantes, Cecilia Zazueta, Armando Luna-López, Abel Santamaría, Mina Königsberg
The brain is a very susceptible organ to structural and functional alterations caused by oxidative stress and its vulnerability increases with age. Understanding the antioxidant response activated by the transcription factor Nrf2 has become very important in the aging field in order to activate cellular protection. However, the role of Nrf2 inducers during old age has not been completely understood. Our aim was to activate the Nrf2 pathway by pre-treating old rats with a widely used Nrf2-inducer, tert-buthylhydroquinone (tBHQ), prior to 3-nitropropionic acid (3-NP) insult, in order to evaluate its effects at a behavioral, morphological and biochemical levels...
August 2017: Redox Biology
https://www.readbyqxmd.com/read/28389882/hormetic-efficacy-of-rutin-to-promote-longevity-in-drosophila-melanogaster
#20
Debarati Chattopadhyay, Atith Chitnis, Aishwarya Talekar, Prajakta Mulay, Manyata Makkar, Joel James, Kavitha Thirumurugan
Hormetins are compounds that mediate hormesis by being beneficial at low doses but detrimental at high doses. Recent studies have highlighted that many compounds that extended lifespan in model organisms did so by mediating hormesis. Rutin is a glycosylate conjugate of quercetin and rutinose and is abundant in citrus fruits and buckwheat seeds. Rutin possess ROS scavenging, anti-cancer, cardio-protective, skin-regenerative and neuro-protective properties. Drosophila melanogaster is an attractive model organism for longevity studies owing to its homology of organ and cellular-pathways with mammals...
June 2017: Biogerontology
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