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Hormetics

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https://www.readbyqxmd.com/read/28439921/impact-of-obstructive-sleep-apnoea-and-intermittent-hypoxia-on-cardiovascular-and-cerebrovascular-regulation
#1
Andrew E Beaudin, Xavier Waltz, Patrick J Hanly, Marc J Poulin
Obstructive sleep apnoea (OSA) is associated with increased risk of cardiovascular and cerebrovascular disease, a consequence attributed in part to chronic intermittent hypoxia (IH) resulting from repetitive apnoeas during sleep. Although findings from experimental animal, and human, models have shown that IH is detrimental to vascular regulation, the severity of IH used in many of these animal studies (e.g. inspired fraction of oxygen (FI O2 ) = 2-3%; oxygen desaturation index (ODI) = 120 events h(-1) ) is considerably greater than that observed in the majority of patients with OSA...
April 24, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28418333/nonlinear-feedback-drives-homeostatic-plasticity-in-h2o2-stress-response
#2
Youlian Goulev, Sandrine Morlot, Audrey Matifas, Bo Huang, Mikael Molin, Michel B Toledano, Gilles Charvin
Homeostatic systems that rely on genetic regulatory networks are intrinsically limited by the transcriptional response time, which may restrict a cell's ability to adapt to unanticipated environmental challenges. To bypass this limitation, cells have evolved mechanisms whereby exposure to mild stress increases their resistance to subsequent threats. However, the mechanisms responsible for such adaptive homeostasis remain largely unknown. Here, we used live-cell imaging and microfluidics to investigate the adaptive response of budding yeast to temporally controlled H2O2 stress patterns...
April 18, 2017: ELife
https://www.readbyqxmd.com/read/28412924/neurons-vs-germline-a-war-of-hormetic-tradeoffs
#3
Marios Kyriazis
The process of human ageing is significantly dependent upon events which are currently shaping humanity. One such event is the seemingly inexorable progress of technology, and specifically, digital communications technology. Technology and biology are tightly interconnected, and this has a direct relevance on how our own ageing mechanisms are evolving and adapting to the change. One way technology may affect biological ageing is based on the concept of information exposure which acts as a hormetic stimulus and up-regulates neuronal stress response pathways...
April 13, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28409426/ethylenediurea-as-a-potential-tool-in-evaluating-ozone-phytotoxicity-a-review-study-on-physiological-biochemical-and-morphological-responses-of-plants
#4
Supriya Tiwari
Present-day climate change scenario has intensified the problem of continuously increasing ground-level ozone (O3), which is responsible for causing deleterious effects on growth and development of plants. Studies involving use of ethylenediurea (EDU), a chemical with antiozonant properties, have given some promising results in evaluating O3 injury in plants. The use of EDU is especially advantageous in developing countries which face a more severe problem of ground-level O3, and technical O3-induced yield loss assessment techniques like open-top chambers cannot be used...
April 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28407662/effects-of-a-one-week-fasting-therapy-in-patients-with-type-2-diabetes-mellitus-and-metabolic-syndrome-a-randomized-controlled-explorative-study
#5
Chenying Li, Badri Sadraie, Nico Steckhan, Christian Kessler, Rainer Stange, Michael Jeitler, Andreas Michalsen
There is increasing experimental evidence for beneficial effects of calorie restriction and intermittent fasting in type 2 diabetes mellitus (T2DM). In humans, prolonged fasting is established as a health-promoting complementary treatment in Europe and claimed to improve metabolism by a complex hormetic response. We aimed to investigate effects of a one-week fasting period compared to usual care in T2DM by means of a pilot trial. Patients with manifest T2DM medically treated with oral hypoglycemic agents and/or insulin were randomly assigned to a 7-day fasting program followed by dietary advice or to usual care and dietary advice only...
April 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28391182/tert-buthylhydroquinone-pre-conditioning-exerts-dual-effects-in-old-female-rats-exposed-to-3-nitropropionic-acid
#6
Alejandro Silva-Palacios, Ana L Colín-González, Stefanie P López-Cervantes, Cecilia Zazueta, Armando Luna-López, Abel Santamaría, Mina Königsberg
The brain is a very susceptible organ to structural and functional alterations caused by oxidative stress and its vulnerability increases with age. Understanding the antioxidant response activated by the transcription factor Nrf2 has become very important in the aging field in order to activate cellular protection. However, the role of Nrf2 inducers during old age has not been completely understood. Our aim was to activate the Nrf2 pathway by pre-treating old rats with a widely used Nrf2-inducer, tert-buthylhydroquinone (tBHQ), prior to 3-nitropropionic acid (3-NP) insult, in order to evaluate its effects at a behavioral, morphological and biochemical levels...
March 31, 2017: Redox Biology
https://www.readbyqxmd.com/read/28389882/hormetic-efficacy-of-rutin-to-promote-longevity-in-drosophila-melanogaster
#7
Debarati Chattopadhyay, Atith Chitnis, Aishwarya Talekar, Prajakta Mulay, Manyata Makkar, Joel James, Kavitha Thirumurugan
Hormetins are compounds that mediate hormesis by being beneficial at low doses but detrimental at high doses. Recent studies have highlighted that many compounds that extended lifespan in model organisms did so by mediating hormesis. Rutin is a glycosylate conjugate of quercetin and rutinose and is abundant in citrus fruits and buckwheat seeds. Rutin possess ROS scavenging, anti-cancer, cardio-protective, skin-regenerative and neuro-protective properties. Drosophila melanogaster is an attractive model organism for longevity studies owing to its homology of organ and cellular-pathways with mammals...
April 7, 2017: Biogerontology
https://www.readbyqxmd.com/read/28333578/hormetic-heat-shock-and-hsf-1-overexpression-improve-c-elegans-survival-and-proteostasis-by-inducing-autophagy
#8
Caroline Kumsta, Malene Hansen
The cellular recycling process of macroautophagy/autophagy is an essential homeostatic system induced by various stresses, but it remains unclear how autophagy contributes to organismal stress resistance. In a recent study, we report that a mild and physiologically beneficial ("hormetic") heat shock as well as overexpression of the heat-shock responsive transcription factor HSF-1 systemically increases autophagy in C. elegans. Accordingly, we found HSF-1- and heat stress-inducible autophagy to be required for C...
March 23, 2017: Autophagy
https://www.readbyqxmd.com/read/28319746/predicting-biphasic-responses-in-binary-mixtures-pelargonic-acid-versus-glyphosate
#9
Regina G Belz, Hans-Peter Piepho
Predicting hormesis in mixtures is challenging, but essential considering that chemical exposures often occur in mixtures and at low doses. This study investigated mixture effects with two herbicides prone to induce hormesis and to interact, namely pelargonic acid versus glyphosate. Five independent mixture experiments were conducted in vitro to assess effects on root growth of lettuce. Mixture effects on the dose were analyzed using classical joint-action models in terms of deviation from the reference model of concentration addition...
March 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/28318788/hormesis-commonly-observed-in-the-assessment-of-aneuploidy-in-yeast
#10
REVIEW
Edward J Calabrese
Extensive dose response studies have assessed the potential of toxic chemical agents to induce aneuploidy in the yeast model. An assessment of such findings revealed that hormetic-like biphasic dose responses were commonly observed. A preliminary estimate of the frequency of the hormetic responses using a priori entry and evaluative criteria was approximately 65-80%.
March 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28287626/using-delaunay-triangulation-and-voronoi-tessellation-to-predict-the-toxicities-of-binary-mixtures-containing-hormetic-compound
#11
Rui Qu, Shu-Shen Liu, Qiao-Feng Zheng, Tong Li
Concentration addition (CA) was proposed as a reasonable default approach for the ecological risk assessment of chemical mixtures. However, CA cannot predict the toxicity of mixture at some effect zones if not all components have definite effective concentrations at the given effect, such as some compounds induce hormesis. In this paper, we developed a new method for the toxicity prediction of various types of binary mixtures, an interpolation method based on the Delaunay triangulation (DT) and Voronoi tessellation (VT) as well as the training set of direct equipartition ray design (EquRay) mixtures, simply IDVequ...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28278681/in-vitro-assessment-of-the-indirect-antioxidant-activity-of-sulforaphane-in-redox-imbalance-vanadium-induced
#12
Giuseppa Visalli, Alessio Facciolà, Maria Paola Bertuccio, Isa Picerno, Angela Di Pietro
Owing to sulforaphane presence, a dietary consumption of Brassicaceae prevents chronic diseases. This hormetic compound induces adaptive stress response at subtoxic doses, while doses that exceed the cellular defence are toxic. In HepG2, Caco-2 and Vero cells, we investigated the sulforaphane (SFN) (5 μM) role in counteracting redox imbalance induced by VOSO4 [V(IV)]. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test showed a dose-dependent viability reduction (r < -0.95; p < 0...
February 8, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28238722/hormetic-modulation-of-hepatic-insulin-sensitivity-by-advanced-glycation-end-products
#13
Nelly T Fabre, Karina Thieme, Karolline S Silva, Sérgio Catanozi, Ana Mercedes Cavaleiro, Danilo A C Pinto, Maristela M Okamoto, Mychel Raony P T Morais, Bárbara Falquetto, Telma M Zorn, Ubiratan F Machado, Marisa Passarelli, Maria Lúcia Correa-Giannella
Because of the paucity of information regarding metabolic effects of advanced glycation end products (AGEs) on liver, we evaluated effects of AGEs chronic administration in (1) insulin sensitivity; (2) hepatic expression of genes involved in AGEs, glucose and fat metabolism, oxidative stress and inflammation and; (3) hepatic morphology and glycogen content. Rats received intraperitoneally albumin modified (AlbAGE) or not by advanced glycation for 12 weeks. AlbAGE induced whole-body insulin resistance concomitantly with increased hepatic insulin sensitivity, evidenced by activation of AKT, inactivation of GSK3, increased hepatic glycogen content, and decreased expression of gluconeogenesis genes...
February 24, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28226195/global-transcriptional-response-of-human-liver-cells-to-ethanol-stress-of-different-strength-reveals-hormetic-behavior
#14
Wolfgang Schmidt-Heck, Eva C Wönne, Thomas Hiller, Uwe Menzel, Dirk Koczan, Georg Damm, Daniel Seehofer, Fanny Knöspel, Nora Freyer, Reinhard Guthke, Steven Dooley, Katrin Zeilinger
BACKGROUND: The liver is the major site for alcohol metabolism in the body and therefore the primary target organ for ethanol (EtOH)-induced toxicity. In this study, we investigated the in vitro response of human liver cells to different EtOH concentrations in a perfused bioartificial liver device that mimics the complex architecture of the natural organ. METHODS: Primary human liver cells were cultured in the bioartificial liver device and treated for 24 hours with medium containing 150 mM (low), 300 mM (medium), or 600 mM (high) EtOH, while a control culture was kept untreated...
February 22, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28198373/hormetic-heat-stress-and-hsf-1-induce-autophagy-to-improve-survival-and-proteostasis-in-c-elegans
#15
Caroline Kumsta, Jessica T Chang, Jessica Schmalz, Malene Hansen
Stress-response pathways have evolved to maintain cellular homeostasis and to ensure the survival of organisms under changing environmental conditions. Whereas severe stress is detrimental, mild stress can be beneficial for health and survival, known as hormesis. Although the universally conserved heat-shock response regulated by transcription factor HSF-1 has been implicated as an effector mechanism, the role and possible interplay with other cellular processes, such as autophagy, remains poorly understood...
February 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28185019/biological-ageing-and-clinical-consequences-of-modern-technology
#16
Marios Kyriazis
The pace of technology is steadily increasing, and this has a widespread effect on all areas of health and society. When we interact with this technological environment we are exposed to a wide variety of new stimuli and challenges, which may modulate the stress response and thus change the way we respond and adapt. In this Opinion paper I will examine certain aspects of the human-computer interaction with regards to health and ageing. There are practical, everyday effects which also include social and cultural elements...
February 9, 2017: Biogerontology
https://www.readbyqxmd.com/read/28134809/hormetic-response-to-low-dose-radiation-focus-on-the-immune-system-and-its-clinical-implications
#17
REVIEW
Jiuwei Cui, Guozi Yang, Zhenyu Pan, Yuguang Zhao, Xinyue Liang, Wei Li, Lu Cai
The interrelationship between ionizing radiation and the immune system is complex, multifactorial, and dependent on radiation dose/quality and immune cell type. High-dose radiation usually results in immune suppression. On the contrary, low-dose radiation (LDR) modulates a variety of immune responses that have exhibited the properties of immune hormesis. Although the underlying molecular mechanism is not fully understood yet, LDR has been used clinically for the treatment of autoimmune diseases and malignant tumors...
January 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28129561/potential-impacts-of-silver-nanoparticles-on-bacteria-in-the-aquatic-environment
#18
REVIEW
Zhiya Sheng, Yang Liu
It is inevitable that nano-silver will be released into the environment. Therefore, there is an urgent need to better understand the effects of silver nanoparticles (Ag-NPs) on microbes in natural and engineered environments. The most remarkable gap in our knowledge on this lies on the low Ag-NPs dose side. This review summarized studies on the effects of Ag-NPs on bacteria from simple to complicated aquatic systems. A hormetic model with a narrow stimulatory zone has been proposed based on both experimental phenomenon and the potential mechanisms of the observed effects...
January 24, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28123580/effects-of-physical-activity-on-systemic-oxidative-dna-status-in-breast-cancer-survivors
#19
Barbara Tomasello, Giuseppe Antonio Malfa, Angela Strazzanti, Santi Gangi, Claudia Di Giacomo, Francesco Basile, Marcella Renis
Physical activity offers a paradoxical hormetic effect and a health benefit to cancer survivors; however, the biochemical mechanisms have not been entirely elucidated. Despite the well-documented evidence implicating oxidative stress in breast cancer, the association between health benefits and redox status has not been investigated in survivors who participate in dragon boating. The present study investigated the plasmatic systemic oxidative status (SOS) in breast cancer survivors involved in two distinct physical training exercises...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28112228/hormetic-effect-of-panaxatriol-saponins-confers-neuroprotection-in-pc12-cells-and-zebrafish-through-pi3k-akt-mtor-and-ampk-sirt1-foxo3-pathways
#20
Chao Zhang, Chuwen Li, Shenghui Chen, Zhiping Li, Lijuan Ma, Xuejing Jia, Kai Wang, Jiaolin Bao, Yeer Liang, Meiwan Chen, Peng Li, Huanxing Su, Simon Ming Yuen Lee, Kechun Liu, Jian-Bo Wan, Chengwei He
Hormesis is an adaptive response of living organisms to a moderate stress. However, its biomedical implication and molecular mechanisms remain to be intensively investigated. Panaxatriol saponins (PTS) is the major bioactive components extracted from Panax notoginseng, a widely used herbal medicine for cerebrovascular diseases. This study aims to examine the hormetic and neuroprotective effects of PTS in PC12 cells and zebrafish Parkinson's disease (PD) models. Our results demonstrated that PTS stimulated PC12 cell growth by about 30% at low doses, while PTS at high doses inhibited cell growth, which is a typical hormetic effect...
January 23, 2017: Scientific Reports
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