keyword
https://read.qxmd.com/read/38514472/deep-learning-reconstruction-for-high-resolution-computed-tomography-images-of-the-temporal-bone-comparison-with-hybrid-iterative-reconstruction
#21
JOURNAL ARTICLE
Nana Fujita, Koichiro Yasaka, Sosuke Hatano, Naoya Sakamoto, Ryo Kurokawa, Osamu Abe
PURPOSE: We investigated whether the quality of high-resolution computed tomography (CT) images of the temporal bone improves with deep learning reconstruction (DLR) compared with hybrid iterative reconstruction (HIR). METHODS: This retrospective study enrolled 36 patients (15 men, 21 women; age, 53.9 ± 19.5 years) who had undergone high-resolution CT of the temporal bone. Axial and coronal images were reconstructed using DLR, HIR, and filtered back projection (FBP)...
March 22, 2024: Neuroradiology
https://read.qxmd.com/read/38513083/letter-to-the-editor-it-s-more-than-burnout-the-moral-injury-crisis-in-orthopaedic-surgeons
#22
JOURNAL ARTICLE
Nana E Coleman, Christopher Iobst
No abstract text is available yet for this article.
March 21, 2024: Clinical Orthopaedics and related Research
https://read.qxmd.com/read/38512863/parasitic-contamination-of-fresh-vegetables-and-fruits-sold-in-open-air-markets-in-peri-urban-areas-of-jimma-city-oromia-ethiopia-a-community-based-cross-sectional-study
#23
JOURNAL ARTICLE
Ahmed Zeynudin, Teshome Degefa, Tariku Belay, Jiru Batu Mumicha, Abdusemed Husen, Jafer Yasin, Abdulhakim Abamecha, Andreas Wieser
BACKGROUND: Consuming contaminated raw vegetables and fruits is one of the primary means of parasite transmission to humans. Periodic monitoring of parasitic contamination in these food items is a crucial step in preventing the spread of parasitic disease in the community. This study was aimed at detecting intestinal parasitic contamination caused by consuming raw vegetables and fruits sold in three open-air markets and its associated factors in peri-urban areas of Jimma City, Oromia, Ethiopia...
2024: PloS One
https://read.qxmd.com/read/38511275/adiponectin-receptor-agonistic-dipeptide-tyr-pro-stimulates-the-acetylcholine-nervous-system-in-ne-4c-cells
#24
JOURNAL ARTICLE
Lihong Cheng, Caiyue Shi, Saya Nakamura, Nana Esaki, Yuka Ichiba, Mitsuru Tanaka, Kenta Sakai, Toshiro Matsui
The dipeptide Tyr-Pro has physiological potential for intact transportability into the brain parenchyma, prevention of cognitive impairment, and an adiponectin receptor 1 (AdipoR1) agonistic effect. The present study aimed to understand the effect of Tyr-Pro on the acetylcholine (ACh) nervous system and its underlying mechanism in NE-4C nerve cells. Concentration-dependent ACh production was induced by stimulation with Tyr-Pro and AdipoRon (an AdipoR1 agonist), along with the expression of AdipoR1 and choline acetyltransferase (ChAT) in NE-4C cells...
March 21, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38510158/physiotherapy-students-rating-on-lecturers-and-supervisors-clinical-education-attributes
#25
JOURNAL ARTICLE
Nana Kwame Safo-Kantanka, Jonathan Quartey, Samuel Koranteng Kwakye
BACKGROUND: Clinical education is considered a vital aspect of education of health science students. Attributes of clinical educators play a crucial role in determining the outcome of clinical teaching and learning. A good clinical educator ensures that students get maximum benefits of the clinical learning experience. OBJECTIVE: To determine the ratings of physiotherapy students on clinical education attributes of lecturers and clinical supervisors. METHODS: The study was conducted with 81 clinical physiotherapy students from two universities in Ghana...
December 2024: Hong Kong Physiotherapy Journal
https://read.qxmd.com/read/38509117/a-structure-based-designed-small-molecule-depletes-hrpn13-pru-and-a-select-group-of-ken-box-proteins
#26
JOURNAL ARTICLE
Xiuxiu Lu, Monika Chandravanshi, Venkata R Sabbasani, Snehal Gaikwad, V Keith Hughitt, Nana Gyabaah-Kessie, Bradley T Scroggins, Sudipto Das, Wazo Myint, Michelle E Clapp, Charles D Schwieters, Marzena A Dyba, Derek L Bolhuis, Janusz W Koscielniak, Thorkell Andresson, Michael J Emanuele, Nicholas G Brown, Hiroshi Matsuo, Raj Chari, Deborah E Citrin, Beverly A Mock, Rolf E Swenson, Kylie J Walters
Proteasome subunit hRpn13 is partially proteolyzed in certain cancer cell types to generate hRpn13Pru by degradation of its UCHL5/Uch37-binding DEUBAD domain and retention of an intact proteasome- and ubiquitin-binding Pru domain. By using structure-guided virtual screening, we identify an hRpn13 binder (XL44) and solve its structure ligated to hRpn13 Pru by integrated X-ray crystallography and NMR to reveal its targeting mechanism. Surprisingly, hRpn13Pru is depleted in myeloma cells following treatment with XL44...
March 20, 2024: Nature Communications
https://read.qxmd.com/read/38504760/cardiovascular-physical-examination-as-a-screening-tool-for-congenital-heart-disease-in-newborns-at-a-teaching-hospital-in-ghana
#27
JOURNAL ARTICLE
Frank Owusu-Sekyere, Bamenla Goka, Della Adzosii, William Obeng, Alfred Yawson, Nana Akyaa-Yao, Sybil Harrison, Justice Moses K Aheto
OBJECTIVES: To determine the usefulness of cardiovascular physical examination (CPE) as a screening tool in a low-resource setting for detecting congenital heart disease (CHD) in newborns delivered at the Maternity Unit of Korle Bu Teaching Hospital (KBTH), Accra, Ghana. DESIGN: A hospital-based cross-sectional study with a comparison group component. SETTING: Maternity Unit of the KBTH, Accra, Ghana. PARTICIPANTS: Over eight months, newborns aged 1-14 days delivered at ≥ 34 weeks' gestation at the Maternity Unit, KBTH, were recruited into the study...
June 2023: Ghana Medical Journal
https://read.qxmd.com/read/38504754/a-multi-centre-investigation-of-macrovascular-and-non-ocular-microvascular-complications-in-children-and-adolescents-with-diabetes-mellitus-in-southern-ghana
#28
JOURNAL ARTICLE
Josephine Akpalu, Vera A Essuman, Winfried M Amoaku, Benjamin Abaidoo, Akye Essuman, Charles Hayfron-Benjamin, Nana A Barnes, Naa N Tagoe, George Asare, Thomas A Ndanu, Benedicta Appiah-Thompson, Imelda D-B Ofori-Adjei, Adziri H Sackey
OBJECTIVES: To investigate the prevalence of macrovascular and non-ocular microvascular complications and the associated factors among children and adolescents with diabetes mellitus in selected hospitals in southern Ghana. DESIGN: A cross-sectional study. SETTING: The out-patient clinics of the Departments of Child Health, Medicine and Therapeutics, Family Medicine, Ophthalmology, and the National Diabetes Management and Research Centre, all at the Korle Bu Teaching Hospital, Accra, as well as from Cape-Coast Teaching Hospital in the Central Region of Ghana...
June 2023: Ghana Medical Journal
https://read.qxmd.com/read/38503949/deciphering-groundwater-pollution-in-the-lower-anayari-catchment-insights-from-using-%C3%AE-2-h-%C3%AE-18-o-pmf-and-apcs-mlr-receptor-model
#29
JOURNAL ARTICLE
Dickson Abdul-Wahab, Ebenezer Aquisman Asare, Rafeah Wahi, Zainab Ngaini, Nana Ama Browne Klutse, Anita Asamoah
This research provides a comprehensive analysis of groundwater pollution in the Lower Anayari Catchment (LAC) through δ2 H and δ18 O isotopic analysis, along with positive matrix factorization (PMF) and PCS-MLR receptor models. Forty groundwater samples were collected from hand-dug wells and equipped boreholes across the LAC. Flame photometry for Na+ and K+ , complexometric titration for Ca2+ , ion chromatography for Cl- , F- , NO3 - , SO4 2- , and PO4 3- , and atomic absorption spectrometry for Mg2+ , Fe, Pb, Cd, As, and Ni were analytical techniques/instruments employed...
March 19, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38503890/systemic-immune-inflammation-index-as-a-prognostic-marker-in-her2-positive-breast-cancer-patients-undergoing-trastuzumab-therapy
#30
JOURNAL ARTICLE
Jian Pang, Nianhua Ding, Nana Yin, Zhi Xiao
The prognostic value of SII (Systemic Immune-Inflammation Index) in HER-2-positive breast cancer (BC) patients, regardless of whether they receive trastuzumab treatment, and its potential value to distinguish patients who may benefit from trastuzumab therapy, warrant further investigation. Clinical data was collected from 797 HER-2-positive BC patients between July 2013 and March 2018. Baseline data differences were adjusted with propensity score matching. Univariate and multivariate analyses explored the correlation between clinical pathological factors, SII, and DFS...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38501239/a-retrospective-analysis-of-10-year-experience-on-branched-and-fenestrated-endovascular-aortic-arch-repair
#31
JOURNAL ARTICLE
Fiona Rohlffs, Petroula Nana, Giuseppe Panuccio, Jose I Torrealba, Nikolaos Tsilimparis, Meike Rybczynski, Christian Detter, Tilo Kölbel
OBJECTIVE: This study aimed to present the early and mid-term outcomes of fenestrated/branched thoracic endovascular aortic repair (f/bTEVAR) for aortic arch pathologies. BACKGROUND: f/bTEVAR represents a less invasive treatment option for aortic arch diseases. Previous published series showed decreased early mortality and morbidity compared to open repair. METHODS: A single-center retrospective analysis of consecutive patients, managed with f/bTEVAR (Cook Medical, Bloomington, IN, USA) between 01...
March 19, 2024: Annals of Surgery
https://read.qxmd.com/read/38499799/a-method-for-predicting-drugs-that-can-boost-the-efficacy-of-immune-checkpoint-blockade
#32
JOURNAL ARTICLE
Yun Xia, Xin Li, Nana Bie, Wen Pan, Ya-Ru Miao, Mei Yang, Yan Gao, Chuang Chen, Hanqing Liu, Lu Gan, An-Yuan Guo
Combination therapy is a promising therapeutic strategy to enhance the efficacy of immune checkpoint blockade (ICB); however, predicting drugs for effective combination is challenging. Here we developed a general data-driven method called CM-Drug for screening compounds that can boost ICB treatment efficacy based on core and minor gene sets identified between responsive and nonresponsive samples in ICB therapy. The CM-Drug method was validated using melanoma and lung cancer mouse models, with combined therapeutic efficacy demonstrated in eight of nine predicted compounds...
March 18, 2024: Nature Immunology
https://read.qxmd.com/read/38499598/characterizing-user-demographics-in-posts-related-to-breast-lung-and-colon-cancer-on-japanese-twitter-x
#33
JOURNAL ARTICLE
Maho Kusudo, Mitsuo Terada, Nari Kureyama, Yumi Wanifuchi-Endo, Takashi Fujita, Tomoko Asano, Akiko Kato, Makiko Mori, Nanae Horisawa, Tatsuya Toyama
Various cancer-related information is spreading on social media. Our study aimed to examine the account types associated with cancer-related tweets (currently known as posts) on Twitter (currently known as X) in Japan, specifically focusing on breast, lung, and colon cancer. Using the Twitter application programming interface, we collected tweets containing keywords of the three cancers type in August-September 2022. The accounts were categorized into seven types: Survivor, Patient's family, Healthcare provider, Public organization, Private organization, News, and Other according to account name and texts...
March 18, 2024: Scientific Reports
https://read.qxmd.com/read/38495180/effect-of-perforated-low-density-polyethylene-films-on-postharvest-quality-of-avocado-fruit
#34
JOURNAL ARTICLE
Nana Millicent Duduzile Buthelezi, Tieho Paulus Mafeo
Avocado ( Persea americana Mill.) being a climacteric fruit, is very prone to quality deterioration and spoilage due to high metabolic activities which leads to postharvest and economic losses. The purpose of this study was to evaluate the impact of perforated low-density polyethylene (LDPE) packaging films on postharvest quality and shelf life of 'Fuerte' avocado. Fruit were packaged in LDPE plastics (20 and 40 μm) whereas unpackaged fruit were considered as control. Fruit were kept at ambient environments (21 ± 1 °C and 60...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38494663/microrna-7-deficiency-ameliorates-d-galactose-induced-aging-in-mice-by-regulating-senescence-of-kupffer-cells
#35
JOURNAL ARTICLE
Ya Wang, Hui Qiu, Shipeng Chen, Dongmei Li, Xu Zhao, Mengmeng Guo, Nana Li, Chao Chen, Ming Qin, Ya Zhou, Daimin Xiao, Juanjuan Zhao, Lin Xu
Aging is intricately linked to immune system dysfunction. Recent studies have highlighted the biological function of microRNA-7 (miR-7) as a novel regulator of immune cell function and related diseases. However, the potential role of miR-7 in aging remains unexplored. Here, we investigated the contribution of miR-7 to d-gal-induced aging in mice, focusing on its regulation of senescent Kupffer cells. Our findings revealed that miR-7 deficiency significantly ameliorated the aging process, characterized by enhanced CD4+ T-cell activation...
March 17, 2024: Aging Cell
https://read.qxmd.com/read/38493517/predictive-value-of-peripheral-blood-leukocytes-based-methylation-of-long-non-coding-rna-malat1-and-h19-in-the-chemotherapy-effect-and-prognosis-of-gastric-cancer
#36
JOURNAL ARTICLE
Fang Wang, Dingtao Hu, Xiaoqi Lou, Linlin Wang, Yuhua Wang, Tingyu Zhang, Ziye Yan, Nana Meng, Yu Lei, Yanfeng Zou
BACKGROUND: The predictive value of the methylation of Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and H19 promoters in peripheral blood leukocytes as a non-invasive biomarker for the chemotherapy effect and prognosis gastric cancer (GC) is unclear. METHODS: The DNA methylation of H19 and MALAT1 between chemotherapy-sensitive and non-sensitive groups and between groups with better and worse survival of GC was compared using regression analyses...
March 16, 2024: Translational Oncology
https://read.qxmd.com/read/38492732/evaluation-of-hemodynamic-properties-after-chimney-and-fenestrated-endovascular-aneurysm-repair
#37
JOURNAL ARTICLE
Stavros Malatos, Laura Fazzini, Anastasios Raptis, Petroula Nana, George Kouvelos, Paola Tasso, Diego Gallo, Umberto Morbiducci, Michail A Xenos, Athanasios Giannoukas, Miltiadis Matsagkas
OBJECTIVES: Fenestrated (FEVAR) and chimney (ChEVAR) endovascular aortic repair have been applied in anatomically suitable complex aortic aneurysms. However, local hemodynamic changes may occur after repair. This study aimed to compare FEVAR's and ChEVAR's hemodynamic properties, focusing on visceral arteries. METHODS: Pre- and post-operative computed tomography angiographies (CTAs) have been used to reconstruct patient-based models. Data of three patients, for each modality, were analyzed...
March 14, 2024: Annals of Vascular Surgery
https://read.qxmd.com/read/38491387/characteristics-of-the-oral-and-gastric-microbiome-in-patients-with-early-stage-intramucosal-esophageal-squamous-cell-carcinoma
#38
JOURNAL ARTICLE
Han Chen, Xingzhou Jiang, Fengyi Zhu, Ruoyun Yang, Xin Yu, Xiaoying Zhou, Nana Tang
BACKGROUND: Oral microbiome dysbacteriosis has been reported to be associated with the pathogenesis of advanced esophageal cancer. However, few studies investigated the potential role of oral and gastric microbiota in early-stage intramucosal esophageal squamous carcinoma (EIESC). METHOD: A total of 104 samples were collected from 31 patients with EIESC and 21 healthy controls. The compositions of oral and gastric microbiota were analyzed using 16 S rRNA V3-V4 amplicon sequencing...
March 15, 2024: BMC Microbiology
https://read.qxmd.com/read/38488481/heterovalent-metal-pair-sites-on-metal-organic-framework-ordered-macropores-for-multimolecular-co-activation
#39
JOURNAL ARTICLE
Zhong Zhang, Xujiao Ma, Yameng Li, Nana Ma, Ming Wang, Wei Liu, Jiahui Peng, Yiwei Liu, Yadong Li
The precise design of catalytic metal centers with multiple chemical states to facilitate sophisticated reactions involving multimolecular activation is highly desirable but challenging. Herein, we report an ordered macroporous catalyst with heterovalent metal pair (HMP) sites comprising CuII -CuI on the basis of a microporous metal-organic framework (MOF) system. This macroporous HMP catalyst with proximity heterovalent dual copper sites, whose distance is controlled to ∼2.6 Å, on macropore surface exhibits a co-activation behavior of ethanol at CuII and alkyne at CuI , and avoids microporous restriction, thereby promoting additive-free alkyne hydroboration reaction...
March 15, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38488047/n1019d-mutant-of-limosilactobacillus-reuteri-121-4-6-%C3%AE-glucanotransferase-gtfb-significantly-improved-catalytic-activity
#40
JOURNAL ARTICLE
Nana Wang, Jingjing Dong, Xiaoxiao Li, Birte Svensson, Zhengyu Jin, Yuxiang Bai
Limosilactobacillus reuteri 121 4,6-α-glucanotransferase GtfB ( Lr 121 GtfB), belonging to glycoside hydrolase family 70 (GH70), synthesizes linear isomalto/malto polysaccharides having (α1→6) linkages attached to the nonreducing ends of (α1→4) linked maltose oligosaccharide segments using starch or maltodextrin as a substrate. Since Lr 121 GtfB has low catalytic activity and efficiency, it leads to substrate regeneration and reduced substrate utilization. In this study, we superimposed the crystal structure of Lr 121 GtfB-ΔNΔV with that of L...
March 15, 2024: Journal of Agricultural and Food Chemistry
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