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https://www.readbyqxmd.com/read/28088650/assessing-the-identity-and-expression-level-of-the-cytochrome-p450-20a1-cyp20a1-gene-in-the-bpa-bde-47-and-waf-exposed-copepods-tigriopus-japonicus-and-paracyclopina-nana
#1
Jeonghoon Han, Duck-Hyun Kim, Jung Soo Seo, Il-Chan Kim, David R Nelson, Jayesh Puthumana, Jae-Seong Lee
CYP20A1 is a member of the cytochrome P450 (CYP) superfamily, identified as an orphan P450 without any assigned biological function; hence, its continued status as an "orphan" gene. In order to address this shortcoming in our understanding of this superfamily, we sought to characterize the CYP20A1 gene in the copepods Tigriopus japonicus (Tj-CYP20A1) and Paracyclopina nana (Pn-CYP20A1) at their mRNA transcriptional level. We assessed the response of this gene's expression in various developmental stages and in response to treatment with bisphenol A (BPA), 2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47), and water accommodated fractions (WAFs) of crude oil...
January 11, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28088239/towards-interruption-of-schistosomiasis-transmission-in-sub-saharan-africa-developing-an-appropriate-environmental-surveillance-framework-to-guide-and-to-support-end-game-interventions
#2
REVIEW
J Russell Stothard, Suzy J Campbell, Mike Y Osei-Atweneboana, Timothy Durant, Michelle C Stanton, Nana-Kwadwo Biritwum, David Rollinson, Dieudonné R Eloundou Ombede, Louis-Albert Tchuem-Tchuenté
Schistosomiasis is a waterborne parasitic disease in sub-Saharan Africa, particularly common in rural populations living in impoverished conditions. With the scale-up of preventive chemotherapy, national campaigns will transition from morbidity- to transmission-focused interventions thus formal investigation of actual or expected declines in environmental transmission is needed as 'end game' scenarios arise. Surprisingly, there are no international or national guidelines to do so in sub-Saharan Africa. Our article therefore provides an introduction to key practicalities and pitfalls in the development of an appropriate environmental surveillance framework...
January 14, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28079912/intravenous-immunoglobulin-in-the-treatment-of-primary-immunodeficiency-diseases
#3
Deirdre De Ranieri, Nana Sarkoah Fenny
Intravenous immunoglobulin (IVIG) has been used as antibody replacement therapy in primary immunodeficiency diseases (PIDDs) for more than 50 years. Its role as a therapeutic agent has expanded over the past couple of decades as its anti-inflammatory and immune-modulatory mechanisms of action have been elucidated. It is now used "off-label" to treat other autoimmune diseases. This article focuses on the role of IVIG in the treatment of PIDDs characterized by absent or deficient antibody production. Replacement doses are given on a monthly basis in these conditions as a prophylactic measure to prevent acute and serious bacterial infections...
January 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28079174/alleviating-liver-failure-conditions-using-an-integrated-hybrid-cryogel-based-cellular-bioreactor-as-a-bioartificial-liver-support
#4
Apeksha Damania, Mohsin Hassan, Nana Shirakigawa, Hiroshi Mizumoto, Anupam Kumar, Shiv K Sarin, Hiroyuki Ijima, Masamichi Kamihira, Ashok Kumar
Conventionally, some bioartificial liver devices are used with separate plasmapheresis unit to separate out plasma from whole blood and adsorbent column to detoxify plasma before it passes through a hepatocytes-laden bioreactor. We aim to develop a hybrid bioreactor that integrates the separate modules in one compact design improving the efficacy of the cryogel based bioreactor as a bioartificial liver support. A plasma separation membrane and an activated carbon cloth are placed over a HepG2-loaded cryogel scaffold in a three-chambered bioreactor design...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28079053/molecular-evidence-for-the-involvement-of-a-polygalacturonase-inhibiting-protein-ghpgip1-in-enhanced-resistance-to-verticillium-and-fusarium-wilts-in-cotton
#5
Nana Liu, Xueyan Zhang, Yun Sun, Ping Wang, Xiancai Li, Yakun Pei, Fuguang Li, Yuxia Hou
Polygalacturonase-inhibiting protein (PGIP), belonging to a group of plant defence proteins, specifically inhibits endopolygalacturonases secreted by pathogens. Herein, we showed that purified GhPGIP1 is a functional inhibitor of Verticillium dahliae and Fusarium oxysporum f. sp. vasinfectum, the two fungal pathogens causing cotton wilt. Transcription of GhPGIP1 was increased in cotton upon infection, wounding, and treatment with defence hormone and H2O2. Resistance by GhPGIP1 was examined by its virus-induced gene silencing in cotton and overexpression in Arabidopsis...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28079004/foodborne-giardiasis-is-there-any-relationship-between-food-handlers-and-transmission-of-giardia-duodenalis
#6
Molouk Beiromvand, Ehsanallah Mirrezaie, Somayeh Mirzavand
BACKGROUND: The foodborne diseases are the main causes of morbidity and mortality in the human communities. Giardia duodenalis, the causative agent of giardiasis, is one of the foodborne parasites, which has public health importance. The aim of the current study was to assess the prevalence of G. duodenalis among food handlers in Andimeshk County, southwest of Iran. MATERIALS AND METHODS: This cross-sectional study was undertaken among 480 food handlers in 2015...
January 10, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28073710/salamatou-nana-and-the-others
#7
G Landrivon, C Grimaldi
No abstract text is available yet for this article.
November 1, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28073050/genome-wide-identification-of-atp-binding-cassette-abc-transporters-and-their-roles-in-response-to-polycyclic-aromatic-hydrocarbons-pahs-in-the-copepod-paracyclopina-nana
#8
Chang-Bum Jeong, Duck-Hyun Kim, Hye-Min Kang, Young Hwan Lee, Hui-Su Kim, Il-Chan Kim, Jae-Seong Lee
The ATP-binding cassette (ABC) protein superfamily is one of the largest gene families and is highly conserved in all domains. The ABC proteins play roles in several biological processes, including multi-xenobiotic resistance (MXR), by functioning as transporters in the cellular membrane. They also mediate the cellular efflux of a wide range of substrates against concentration gradients. In this study, 37 ABC genes belonging to eight distinct subfamilies were identified in the marine copepod Paracyclopina nana and annotated based on a phylogenetic analysis...
December 30, 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/28072472/sonographic-findings-of-chondral-avulsion-fractures-of-the-lateral-ankle-ligaments-in-children
#9
Manabu Maeda, Nana Maeda, Takanori Takaoka, Yasuhito Tanaka
In this series, we aimed to describe the sonographic findings of chondral avulsion fractures that develop concomitant with lateral ankle ligament injury in children. We performed stress sonography during a manual anterior drawer stress procedure of the ankle in 9 skeletally immature patients who had recently had a lateral ankle sprain. Echo videos were obtained through the course of treatment, and all videos were reviewed. We elucidated the common features of chondral avulsion fractures of the lateral ankle ligaments in the children...
January 10, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28064192/leaf-anatomy-bvoc-emission-and-co2-exchange-of-arctic-plants-following-snow-addition-and-summer-warming
#10
Michelle Schollert, Minna Kivimäenpää, Anders Michelsen, Daan Blok, Riikka Rinnan
BACKGROUND AND AIMS: Climate change in the Arctic is projected to increase temperature, precipitation and snowfall. This may alter leaf anatomy and gas exchange either directly or indirectly. Our aim was to assess whether increased snow depth and warming modify leaf anatomy and affect biogenic volatile organic compound (BVOC) emissions and CO2 exchange of the widespread arctic shrubs Betula nana and Empetrum nigrum ssp. hermaphroditum METHODS: Measurements were conducted in a full-factorial field experiment in Central West Greenland, with passive summer warming by open-top chambers and snow addition using snow fences...
January 7, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28063579/classification-of-nine-malathion-emulsion-samples-by-using-carbon-isotope-ratios-and-the-ratio-of-organic-solvents
#11
Nana Suto, Hiroto Kawashima
The compound specific isotope analysis is nowadays an important and powerful tool in geochemical, environmental and forensics field. On November 2013, Aqli Foods Corporation in Japan dealt with complaints about stench from frozen foods produced. Subsequently, very high concentrations of organophosphorus pesticide as malathion, ethylbenzene and xylene were detected in recovered frozen foods. In particular case, we present the method to measure the stable carbon isotope ratio (δ(13)C) of nine malathion emulsion pesticides using gas chromatography/isotope ratio mass spectrometry (GC/IRMS) to identify the source...
January 2017: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/28060874/salmon-dna-accelerates-bone-regeneration-by-inducing-osteoblast-migration
#12
Ayako Sato, Hiroshi Kajiya, Nana Mori, Hironobu Sato, Tadao Fukushima, Hirofumi Kido, Jun Ohno
The initial step of bone regeneration requires the migration of osteogenic cells to defective sites. Our previous studies suggest that a salmon DNA-based scaffold can promote the bone regeneration of calvarial defects in rats. We speculate that the salmon DNA may possess osteoinductive properties, including the homing of migrating osteogenic cells. In the present study, we investigated the influence of the salmon DNA on osteoblastic differentiation and induction of osteoblast migration using MG63 cells (human preosteoblasts) in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28059404/second-order-nlo-responses-of-two-cavity-inorganic-electrides-lin-b20h26-n-1-2-evolutions-with-increasing-excess-electron-number-and-various-b-b-connection-sites-of-b20h26
#13
Nana Ma, Jinjin Gong, Shujun Li, Jie Zhang, Yongqing Qiu, Guisheng Zhang
Confining excess electrons in a specific space is an effective strategy to design nonlinear optical (NLO) molecules. The complexants with excess electrons are usually organic compounds, but these compounds are thermally unstable and thus hardly meet the processing requirements of NLO materials. To obtain better thermostability and NLO response molecules, in this work, inorganic compounds of B20H26 isomers containing two cavities were proposed. With the two included cavities, B20H26 can be doped by one or two Li atoms to form electrides of Li@B20H26 and Li2@B20H26...
January 6, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28056021/comparison-of-doxycycline-minocycline-doxycycline-plus-albendazole-and-albendazole-alone-in-their-efficacy-against-onchocerciasis-in-a-randomized-open-label-pilot-trial
#14
Ute Klarmann-Schulz, Sabine Specht, Alexander Yaw Debrah, Linda Batsa, Nana Kwame Ayisi-Boateng, Jubin Osei-Mensah, Yusif Mubarik, Peter Konadu, Arcangelo Ricchiuto, Rolf Fimmers, Sandra Arriens, Bettina Dubben, Louise Ford, Mark Taylor, Achim Hoerauf
: The search for new macrofilaricidal drugs against onchocerciasis that can be administered in shorter regimens than required for doxycycline (DOX, 200mg/d given for 4-6 weeks), identified minocycline (MIN) with superior efficacy to DOX. Further reduction in the treatment regimen may be achieved with co-administration with standard anti-filarial drugs. Therefore a randomized, open-label, pilot trial was carried out in an area in Ghana endemic for onchocerciasis, comprising 5 different regimens: the standard regimen DOX 200mg/d for 4 weeks (DOX 4w, N = 33), the experimental regimens MIN 200mg/d for 3 weeks (MIN 3w; N = 30), DOX 200mg/d for 3 weeks plus albendazole (ALB) 800mg/d for 3 days (DOX 3w + ALB 3d, N = 32), DOX 200mg/d for 3 weeks (DOX 3w, N = 31) and ALB 800mg for 3 days (ALB 3d, N = 30)...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28055295/igg-fc-variant-cross-reactivity-between-human-and-rhesus-macaque-fc%C3%AE-rs
#15
Austin W Boesch, Adam R Miles, Ying N Chan, Nana Y Osei-Owusu, Margaret E Ackerman
Non-human primate (NHP) studies are often an essential component of antibody development efforts prior to human trials. Because the efficacy or toxicity of candidate antibodies may depend on their interactions with Fcγ receptors (FcγR) and their resulting ability to induce FcγR-mediated effector functions such as antibody-dependent cell-meditated cytotoxicity and phagocytosis (ADCP), the evaluation of human IgG variants with modulated affinity towards human FcγR is becoming more prevalent in both infectious disease and oncology studies in NHP...
January 5, 2017: MAbs
https://www.readbyqxmd.com/read/28054976/an-improved-approach-for-estimating-daily-net-radiation-over-the-heihe-river-basin
#16
Bingfang Wu, Shufu Liu, Weiwei Zhu, Nana Yan, Qiang Xing, Shen Tan
Net radiation plays an essential role in determining the thermal conditions of the Earth's surface and is an important parameter for the study of land-surface processes and global climate change. In this paper, an improved satellite-based approach to estimate the daily net radiation is presented, in which sunshine duration were derived from the geostationary meteorological satellite (FY-2D) cloud classification product, the monthly empirical as and bs Angstrom coefficients for net shortwave radiation were calibrated by spatial fitting of the ground data from 1997 to 2006, and the daily net longwave radiation was calibrated with ground data from 2007 to 2010 over the Heihe River Basin in China...
January 4, 2017: Sensors
https://www.readbyqxmd.com/read/28054671/natriuretic-peptide-type-c-induces-sperm-attraction-for-fertilization-in-mouse
#17
Nana Kong, Xiaoting Xu, Yu Zhang, Yakun Wang, Xiaoqiong Hao, Yu Zhao, Jie Qiao, Guoliang Xia, Meijia Zhang
Mammalian spermatozoa undergo selective movement along the isthmus of the oviduct to the ampulla during ovulation, which is a prerequisite for fertilization. The factor(s) that involves in selective spermatozoa movement is still unknown. In this study, we found that the oviductal epithelium in mouse ampulla expressed high levels of natriuretic peptide type C (NPPC) in the presence of ovulated oocyte-cumulus complexes (OCCs). Spermatozoa expressed NPPC receptor natriuretic peptide receptor 2 (NPR2, a guanylyl cyclase) on the midpiece of flagellum...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28054185/characterization-of-human-hybrid-cell-line-f2n78-through-a-comparison-of-culture-performances-and-protein-qualities
#18
Joon Serk Seo, Byung Sub Min, Yeon Jung Kim, Jong Moon Cho, Gi-Seong Kwon, Byeong-Pil Lim, Shin-Jae Chang, Dong-Il Kim
OBJECTIVES: To evaluate the characteristics of a novel human cell line, F2N78, including growth performance, physicochemical properties, and biological activity via direct comparison with CHO cells. RESULTS: The culture performance and physicochemical properties of antibodies produced from F2N78 and CHO cells were compared. For charge variants, antibodies produced from F2N78 cells contained a greater acidic charge variants than CHO cells. Regarding main glycoforms, degree of galactosylation was 52% in CT-A produced from F2N78 cells compared to CHO cells (37%)...
January 4, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28051949/stereological-assessment-of-the-total-number-of-hypoglossal-neurons-after-repeated-crush-injuries-to-the-hypoglossal-nerve-in-adult-rats
#19
Nanae Fukushima, Mika Karasawa, Kumiko Yokouchi, Norimi Sumitomo, Kyutaro Kawagishi, Tetsuji Moriizumi
OBJECTIVE: Retrograde neuronal cell death does not occur in mature motoneurons following the axonal injury of peripheral nerves. However, a previous study suggested that retrograde neuronal cell death does occur in adult rats after the creation of double lesions on the hypoglossal (XII) nerve based on a substantial decrease in the number of XII neurons. Using stereological methods, we examined neuronal apoptosis in XII neurons and the total number of XII neurons following repeated crush injuries to the XII nerve...
January 4, 2017: Neurological Research
https://www.readbyqxmd.com/read/28051172/therapeutic-hypothermia-for-neonatal-encephalopathy-a-report-from-the-first-3-years-of-the-baby-cooling-registry-of-japan
#20
Kennosuke Tsuda, Takeo Mukai, Sachiko Iwata, Jun Shibasaki, Takuya Tokuhisa, Tomoaki Ioroi, Hiroyuki Sano, Nanae Yutaka, Akihito Takahashi, Akihito Takeuchi, Toshiki Takenouchi, Yuko Araki, Hisanori Sobajima, Masanori Tamura, Shigeharu Hosono, Makoto Nabetani, Osuke Iwata
Therapeutic hypothermia is recommended for moderate and severe neonatal encephalopathy, but is being applied to a wider range of neonates than originally envisaged. To examine the clinical use of therapeutic hypothermia, data collected during the first 3 years (2012-2014) of the Baby Cooling Registry of Japan were analysed. Of 485 cooled neonates, 96.5% were ≥36 weeks gestation and 99.4% weighed ≥1,800 g. Severe acidosis (pH < 7 or base deficit ≥16 mmol/L) was present in 68.9%, and 96.7% required resuscitation for >10 min...
January 4, 2017: Scientific Reports
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