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https://www.readbyqxmd.com/read/28803728/distinct-cellular-mechanisms-underlie-anti-ctla-4-and-anti-pd-1-checkpoint-blockade
#1
Spencer C Wei, Jacob H Levine, Alexandria P Cogdill, Yang Zhao, Nana-Ama A S Anang, Miles C Andrews, Padmanee Sharma, Jing Wang, Jennifer A Wargo, Dana Pe'er, James P Allison
Immune-checkpoint blockade is able to achieve durable responses in a subset of patients; however, we lack a satisfying comprehension of the underlying mechanisms of anti-CTLA-4- and anti-PD-1-induced tumor rejection. To address these issues, we utilized mass cytometry to comprehensively profile the effects of checkpoint blockade on tumor immune infiltrates in human melanoma and murine tumor models. These analyses reveal a spectrum of tumor-infiltrating T cell populations that are highly similar between tumor models and indicate that checkpoint blockade targets only specific subsets of tumor-infiltrating T cell populations...
August 9, 2017: Cell
https://www.readbyqxmd.com/read/28793024/socioenvironmental-conditions-and-intestinal-parasitic-infections-in-brazilian-urban-slums-a-cross-sectional-study
#2
Caroline Ferraz Ignacio, Milena Enderson Chagas da Silva, Natasha Berendonk Handam, Maria de Fatima Leal Alencar, Adriana Sotero-Martins, Martha Macedo de Lima Barata, Antonio Henrique Almeida de Moraes
Methods: A cross-sectional study covering an agglomeration of urban slums was conducted between 2015 and 2016 using participants observation, a socioeconomic survey, and the spontaneous sedimentation method with three slides per sample to analyze fresh stool specimens ( n =595) searching for intestinal parasites. Results: Endolimax nana ( n =95, 16.0%) and Entamoeba coli ( n =65, 10.9%) were the most frequently identified agents, followed by Giardia intestinalis ( n =24, 4...
August 7, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28791467/banana-fusarium-wilt-disease-incidence-is-influenced-by-shifts-of-soil-microbial-communities-under-different-monoculture-spans
#3
Zongzhuan Shen, C Ryan Penton, Nana Lv, Chao Xue, Xianfu Yuan, Yunze Ruan, Rong Li, Qirong Shen
The continuous cropping of banana in the same field may result in a serious soil-borne Fusarium wilt disease and a severe yield decline, a phenomenon known as soil sickness. Although soil microorganisms play key roles in maintaining soil health, the alternations of soil microbial community and relationship between these changes and soil sickness under banana monoculture are still unclear. Bacterial and fungal communities in the soil samples collected from banana fields with different monoculture spans were profiled by sequencing of the 16S rRNA genes and internal transcribed spacer using the MiSeq platform to explore the relationship between banana monoculture and Fusarium wilt disease in the present study...
August 8, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28790813/asynchrony-in-respiratory-movements-between-the-pulmonary-lobes-in-patients-with-copd-continuous-measurement-of-lung-density-by-4-dimensional-dynamic-ventilation-ct
#4
Tsuneo Yamashiro, Hiroshi Moriya, Shin Matsuoka, Yukihiro Nagatani, Maho Tsubakimoto, Nanae Tsuchiya, Sadayuki Murayama
PURPOSE: Four-dimensional dynamic-ventilation CT imaging demonstrates continuous movement of the lung. The aim of this study was to assess the correlation between interlobar synchrony in lung density and spirometric values in COPD patients and smokers, by measuring the continuous changes in lung density during respiration on the dynamic-ventilation CT. MATERIALS AND METHODS: Thirty-two smokers, including ten with COPD, underwent dynamic-ventilation CT during free breathing...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28790247/-pulmonary-mucoepidermoid-carcinoma-with-hilar-lymph-node-metastasis-complicated-by-myelodysplastic-syndrome
#5
Yoshinari Matsuda, Hiroshi Moriyama, Masashi Inaba, Yoshihiko Kubo, Masahiro Kitada, Satoshi Hayashi, Kei Ishibashi, Satoshi Okazaki, Nana Takahashi, Shunsuke Yasuda, Masahiro Abe, Satoshi Hirata
A 65-year-old woman was found to have a mass shadow on chest computed tomography. The patient had been diagnosed as having myelodysplastic syndrome 3 years before admission. She was transferred to our hospital for further examination of the mass in the lower lobe of left lung. The mass was positron emission tomography-positive (SUVmax of 8.6)suggesting a malignant neoplasm. Serum concentrations of carcinoembryonic antigen was elevated to 8.7 ng/ml. Preoperative laboratory studies showed anemia (hemoglobin 6...
August 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28783899/development-of-a-phage-chemiluminescent-enzyme-immunoassay-with-high-sensitivity-for-the-determination-of-imidaclothiz-in-agricultural-and-environmental-samples
#6
Yuan Ding, Xiude Hua, Nana Sun, Jiachuan Yang, Jiaqi Deng, Haiyan Shi, Minghua Wang
In this study, we isolated six phage-displayed peptides by biopanning phage-displayed peptide libraries on an immobilized anti-imidaclothiz monoclonal antibody. After analyzing the relative sensitivity of the individual phage-displayed peptides, we subsequently developed and optimized both a phage enzyme immunoassay (P-ELISA) and a phage chemiluminescent enzyme immunoassay (P-CLEIA) to improve the sensitivity and linear range of imidaclothiz assays. The P-CLEIA (50% inhibition concentration (IC50) of 0.86ngmL(-1), linear range of 0...
July 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28782660/evaluation-and-management-of-primary-ovarian-insufficiency-in-adolescents-and-young-adults
#7
Rula V Kanj, Nana Ama Ofei-Tenkorang, Mekibib Altaye, Catherine M Gordon
STUDY OBJECTIVE: To identify clinical features associated with primary ovarian insufficiency (POI) and collect data on the evaluation and treatment received. DESIGN: Retrospective chart review. Data abstracted on etiology of POI, history, laboratory evaluation, imaging results, return for clinical care, and treatment plans. SETTING: Urban children's hospital in Cincinnati, Ohio. PARTICIPANT: s: 50 females, age 11-26 years, with initial presentation of POI between January 1, 2006-December 31, 2015...
August 3, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28780368/atlanto-occipital-catheterization-of-young-rats-for-long-term-drug-delivery-into-the-lumbar-subarachnoid-space-combined-with-in-vivo-testing-and-electrophysiology-in-situ
#8
Olga Kopach, Volodymyr Krotov, Nana Voitenko
BACKGROUND: Catheterization has been widely used in neuroscience and pain research for local drug delivery. Though different modifications were developed, the use of young animals for spinal catheterization remains limited because of a little success rate. A reliable technique is needed to catheterize young animals aimed for in vivo testing combined with spinal cord electrophysiology, often limited by animal age, to facilitate pain research. NEW METHODS: We describe intrathecal catheterization of young rats (3-week-old) through atlanto-occipical approach for long-lasting drug delivery into the lumbar subarachnoid space...
August 2, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28775232/silencing-heme-oxygenase-1-increases-the-sensitivity-of-abc-dlbcl-cells-to-histone-deacetylase-inhibitor-in-vitro-and-in-vivo
#9
Zhen Zhou, Qin Fang, Dan Ma, Nana Zhe, Mei Ren, Bingqing Cheng, Peifan Li, Ping Liu, Xiaojing Lin, Sishi Tang, Xiuying Hu, Yudan Liao, Yaming Zhang, Tingting Lu, Jishi Wang
Heme oxygenase-1 (HO-1) can promote tumor growth and reinforce the resistance of diffuse large B-cell lymphoma (DLBCL) cells to chemotherapeutic drug vincristine. We herein found that HO-1 protein expression was higher in high-risk DLBCL patients than in low-risk ones. Silencing HO-1 gene expression resisted vorinostat-induced apoptosis and arrested cell cycle in the G0/G1 phase of LY-10 cells. Western blot, co-immunoprecipitation and chromatin immunoprecipitation assays confirmed that the possible mechanisms may be increased cleaved caspase-3 protein expression, decreased phospho-histone deacetylase 3 protein expression, and activated histone acetylation of P27Kip1 promoter...
July 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28774318/important-progress-towards-elimination-of-onchocerciasis-in-the-west-region-of-cameroon
#10
Guy-Roger Kamga, Fanny N Dissak-Delon, Hugues C Nana-Djeunga, Benjamin D Biholong, Stephen Mbigha Ghogomu, Jacob Souopgui, Joseph Kamgno, Annie Robert
BACKGROUND: After more than a decade of community-directed treatment with ivermectin (CDTI) in the West Region of Cameroon, epidemiological evaluation conducted in 2011 showed that onchocerciasis endemicity was still high in some communities. The conceptual framework for onchocerciasis elimination recommends in such case, to conduct additional phase 1A surveys at intervals of three to four years. Therefore, to assess the progress made towards the elimination of onchocerciasis in the West CDTI projects, we conducted a cross-sectional survey in May 2015 in 15 unevaluated communities where the highest baseline endemicity level were found in 1996...
August 3, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28770589/implications-of-differentiated-care-for-successful-art-scale-up-in-a-concentrated-hiv-epidemic-in-yangon-myanmar
#11
REVIEW
Anita Mesic, Julie Fontaine, Theingy Aye, Jane Greig, Thin Thin Thwe, Laura Moretó-Planas, Jarmila Kliesckova, Khin Khin, Nana Zarkua, Lucia Gonzalez, Erwin Lloyd Guillergan, Daniel P O'Brien
INTRODUCTION: National AIDS Programme in Myanmar has made significant progress in scaling up antiretroviral treatment (ART) services and recognizes the importance of differentiated care for people living with HIV. Indeed, long centred around the hospital and reliant on physicians, the country's HIV response is undergoing a process of successful decentralization with HIV care increasingly being integrated into other health services as part of a systematic effort to expand access to HIV treatment...
July 21, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28770395/interventional-nephrology-current-status-and-clinical-impact-in-japan
#12
Masato Ikeda, Hiroyuki Terawaki, Eiichiro Kanda, Maiko Furuya, Yudo Tanno, Masatsugu Nakao, Yukio Maruyama, Masutaka Maeda, Chieko Higuchi, Tsutomu Sakurada, Tomohiro Kaneko, Hiroaki Io, Koji Hashimoto, Atsushi Ueda, Keita Hirano, Naoki Washida, Hiraku Yoshida, Kazuhiro Yoshikawa, Yoshihiro Taniyama, Kenji Harada, Nanae Matsuo, Ichiro Okido, Takashi Yokoo
BACKGROUND: Current status and clinical significance of interventional nephrology has not been reported from Japan. METHODS: Questionnaires were mailed twice to the directors of all 534 Japanese certificated nephrology training institutions in 2014. The main questions were current performance, categorized annual procedure volume and managers of peritoneal dialysis (PD) access, vascular access (VA) surgery, endovascular intervention, and kidney biopsy. Frequencies of nephrologist involvement between high volume center and low volume center and association between the level of nephrologists' involvement to each procedure and annual procedure volume were examined...
August 2, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28766099/efficacy-of-palonosetron-to-prevent-delayed-nausea-and-vomiting-in-non-hodgkin-s-lymphoma-patients-undergoing-repeated-cycles-of-the-chop-regimen
#13
Bungo Saito, Hidetoshi Nakashima, Maasa Abe, So Murai, Yuta Baba, Nana Arai, Yukiko Kawaguchi, Shun Fujiwara, Nobuyuki Kabasawa, Hiroyuki Tsukamoto, Yui Uto, Hirotsugu Ariizumi, Kouji Yanagisawa, Norimichi Hattori, Hiroshi Harada, Tsuyoshi Nakamaki
PURPOSE: Few studies have investigated the effect of palonosetron on delayed chemotherapy-induced nausea and vomiting in lymphoma patients receiving the CHOP regimen. We conducted a prospective clinical trial to assess the efficacy of palonosetron in patients receiving the CHOP regimen. METHODS: Complete control (CC: emesis-free and mild nausea) during delayed phase (24-120 h) was the primary endpoint. The secondary endpoint was complete response (CR: emesis-free) during acute (0-24 h), delayed, and overall phases (0-120 h), and CC during acute and overall phases...
August 2, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28759830/forearm-nonunion-caused-by-hyperparathyroidism-with-7-years-follow-up-a-case-report
#14
Mayuko Kinoshita, Kiyohito Naito, Kentaro Aritomi, Yoichi Sugiyama, Nana Nagura, Kenji Goto, Yoshiyuki Iwase, Kazuo Kaneko
INTRODUCTION: We report a patient who developed nonunion of both bones of the forearm associated with hyperparathyroidism (HPT). PRESENTATION OF CASE: The patient was a 71-year-old female who previously fell and hit her left hand on the ground. At 2 years after injury the patient visited our hospital, since she became aware of instability of the left forearm without an inducer due to nonunion of the radioulnar diaphysis. The patient was surgically treated to acquire forearm support...
July 21, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28759728/molecular-cytogenetic-identification-of-wheat-thinopyrum-ponticum-substitution-line-with-stripe-rust-resistance
#15
Chen Zhu, Yanzhen Wang, Chunhuan Chen, Changyou Wang, Aicen Zhang, Nana Peng, Yajuan Wang, Hong Zhang, Xinlun Liu, Wanquan Ji
Thinopyrum ponticum (Th. ponticum) (2n = 10x = 70) is an important breeding material with excellent resistance and stress tolerance. In this study, we characterized the derivative line CH1113-B13-1-1-2-1 (CH1113-B13) through cytological, morphological, Genomic in situ hybridization (GISH), Fluorescence in situ hybridization (FISH), expressed sequence tag (EST), and PCR-based landmark unique gene (PLUG) marker analysis. The GISH analysis revealed that CH1113-B13 contained 20 pairs of common wheat chromosomes and one pair of J<sup>St</sup> genomic chromosomes...
July 31, 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28759712/mechanisms-of-action-of-nonpeptide-hormones-on-resveratrol-induced-antiproliferation-of-cancer-cells
#16
REVIEW
Hung-Yun Lin, Meng-Ti Hsieh, Guei-Yun Cheng, Hsuan-Yu Lai, Yu-Tang Chin, Ya-Jung Shih, André Wendindondé Nana, Shin-Ying Lin, Yu-Chen S H Yang, Heng-Yuan Tang, I-Jen Chiang, Kuan Wang
Nonpeptide hormones, such as thyroid hormone, dihydrotestosterone, and estrogen, have been shown to stimulate cancer proliferation via different mechanisms. Aside from their cytosolic or membrane-bound receptors, there are receptors on integrin αv β3 for nonpeptide hormones. Interaction between hormones and integrin αv β3 can induce signal transduction and eventually stimulate cancer cell proliferation. Resveratrol induces inducible COX-2-dependent antiproliferation via integrin αv β3 . Resveratrol and hormone-induced signals are both transduced by activated extracellular-regulated kinases 1 and 2 (ERK1/2); however, hormones promote cell proliferation, while resveratrol induces antiproliferation in cancer cells...
July 31, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28757507/analysis-of-body-mass-changes-in-the-black-headed-gull-larus-ridibundus-during-the-winter
#17
Nana Ushine, Tatsuo Sato, Takuya Kato, Shin-Ichi Hayama
During the autumn migration of many waterfowls, body mass is lowest upon arrival at the wintering area and gradually increases during the winter. Consequently, body mass is highest before the spring migration. We studied the pattern of body mass changes in the Black-Headed Gull (Larus ridibundus) from December 2010 to December 2016 in the Shinhama area of Chiba, Japan. Based on 327 captured animals, body mass increased during the wintering period, but tended to decrease before migration. In 2014-2016, a muscle mass reduction in females was observed, explaining the change in body mass...
July 29, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28754388/rationale-design-and-baseline-characteristics-of-participants-in-the-cardiovascular-outcomes-for-people-using-anticoagulation-strategies-compass-trial
#18
Jackie Bosch, John W Eikelboom, Stuart J Connolly, Nancy Cook Bruns, Vivian Lanius, Fei Yuan, Frank Misselwitz, Edmond Chen, Rafael Diaz, Marco Alings, Eva M Lonn, Petr Widimsky, Masatsugu Hori, Alvaro Avezum, Leopoldo S Piegas, Deepak L Bhatt, Kelley R H Branch, Jeffrey L Probstfield, Yan Liang, Lisheng Liu, Jun Zhu, Aldo P Maggioni, Patricio Lopez-Jaramillo, Martin O'Donnell, Keith A A Fox, Ajay Kakkar, Alexander N Parkhomenko, Georg Ertl, Stefan Störk, Katalin Keltai, Matyas Keltai, Lars Ryden, Gilles R Dagenais, Nana Pogosova, Antonio L Dans, Fernando Lanas, Patrick J Commerford, Christian Torp-Pedersen, Tomasz J Guzik, Peter B Verhamme, Dragos Vinereanu, Jae-Hyung Kim, Jong-Won Ha, Andrew M Tonkin, John D Varigos, Basil S Lewis, Camilo Felix, Khalid Yusoff, Philippe Gabriel Steg, Victor Aboyans, Kaj P Metsarinne, Sonia S Anand, Robert G Hart, Andre Lamy, Paul Moayyedi, Darryl P Leong, Mukul Sharma, Salim Yusuf
BACKGROUND: Long-term aspirin prevents vascular events but is only modestly effective. Rivaroxaban alone or in combination with aspirin might be more effective than aspirin alone for vascular prevention in patients with stable coronary artery disease (CAD) or peripheral artery disease (PAD). Rivaroxaban as well as aspirin increase upper gastrointestinal (GI) bleeding and this might be prevented by proton pump inhibitor therapy. METHODS: Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) is a double-blind superiority trial comparing rivaroxaban 2...
August 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28752258/allogeneic-reduced-intensity-hematopoietic-stem-cell-transplantation-for-chronic-granulomatous-disease-a-single-center-prospective-trial
#19
Mark Parta, Corin Kelly, Nana Kwatemaa, Narda Theobald, Diane Hilligoss, Jing Qin, Douglas B Kuhns, Christa Zerbe, Steven M Holland, Harry Malech, Elizabeth M Kang
PURPOSE: The purpose of this study was to evaluate engraftment and adverse events with a conditioning and prophylactic regimen intended to achieve high rates of engraftment with minimal graft-versus-host disease (GVHD) in allogeneic transplantation for chronic granulomatous disease in a single center. METHODS: Forty patients, 37 male, with chronic granulomatous disease were transplanted. Transplant products were matched sibling peripheral blood stem cells (PBSCs) in four and matched unrelated donor (MUD) bone marrow in three, and one patient received mismatched unrelated PBSCs...
July 28, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28751143/n-alkyl-1-1-biphenyl-2-sulfonamide-derivatives-as-novel-broad-spectrum-anti-epileptic-drugs-with-efficacy-equivalent-to-that-of-sodium-valproate
#20
Tomoyuki Tanaka, Nana Yajima, Tomoko Kiyoshi, Yoshiki Miura, Seiji Iwama
In order to develop phenyl sulfonamides as a novel class of anti-epileptic drugs (AED) for both general and partial seizure, we initiated in vivo screening of our chemical library in the mice MES and sc-PTZ models and found compounds 1 and 2 as lead compounds. Optimization of 1 and 2 led to the discovery of compound 21, which showed potent anticonvulsant effect in MES, scPTZ and rat amygdala kindling models. These findings indicate that compound 21 could be a useful new broad spectrum AED like sodium valproate and provide an opportunity to struggle current therapy-resistant epilepsy...
July 13, 2017: Bioorganic & Medicinal Chemistry Letters
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