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https://www.readbyqxmd.com/read/28547803/effects-of-maltose-and-lysine-treatment-on-coffee-aroma-by-flash-gas-chromatography-electronic-nose-and-gas-chromatography-mass-spectrometry
#1
He Yuqin, Zhang Haide, Wen Nana, Hu Rongsuo, Wu Guiping, Zeng Ying, Li Xiong, Miao Xiaodan
BACKGROUND: Arabica coffee is a subtropical agricultural product in China. Coffee undergoes a series of thermal reactions to form abundant volatile profiles after roasting, so it loses a lot of reducing sugars and amino acids. Adding carbonyl compounds with amino acids before roasting could ensure the nutrition and flavor of coffee. The technology is versatile for the development of coffee roasting process. This investigation evaluates the effects of combining maltose and lysine (Lys) to modify coffee aroma and the possibly related mechanisms...
May 26, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28543875/unconjugated-interferon-stimulated-gene-15-specifically-interacts-with-the-hepatitis-c-virus-ns5a-protein-via-domain-i
#2
Nanae Minami, Takayuki Abe, Lin Deng, Chieko Matsui, Takasuke Fukuhara, Yoshiharu Matsuura, Ikuo Shoji
Interferon-stimulated gene 15 (ISG15) is a ubiquitin-like protein induced by type I interferon. Although several groups have reported ISGylation of the HCV NS5A protein, it is still unclear whether ISGylation of NS5A has anti-viral or pro-viral effects in HCV infection. In the present study, we examined the role of ISGylation-independent, unconjugated ISG15 in HCV infection. Immunoprecipitation analyses revealed that ISG15 specifically interacted with NS5A domain I. The ISG15 mutants lacking a C-terminal glycine residue essential for ISGylation still interacted with NS5A protein...
May 25, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28542839/how-whales-used-to-filter-exceptionally-preserved-baleen-in-a-miocene-cetotheriid
#3
Felix G Marx, Alberto Collareta, Anna Gioncada, Klaas Post, Olivier Lambert, Elena Bonaccorsi, Mario Urbina, Giovanni Bianucci
Baleen is a comb-like structure that enables mysticete whales to bulk feed on vast quantities of small prey, and ultimately allowed them to become the largest animals on Earth. Because baleen rarely fossilises, extremely little is known about its evolution, structure and function outside the living families. Here we describe, for the first time, the exceptionally preserved baleen apparatus of an entirely extinct mysticete morphotype: the Late Miocene cetotheriid, Piscobalaena nana, from the Pisco Formation of Peru...
May 24, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28541816/influences-of-socio-demographic-factors-and-health-utilization-factors-on-patient-centered-provider-communication
#4
Shipra Singh, Na'Tasha Evans, Monica Williams, Nilgun Sezginis, Nana Ama Kwarteng Baryeh
Patient-centered care has been documented as a measure of quality of health care and has been associated with positive health outcomes. However, the effect of health utilization on improving patient-centered communication has not been investigated. This study examined the effect of three important kinds of health utilization: routine check-up, frequency of provider visits in the last year, and quality of health care to patient-centered provider communication. Cross-sectional data from 3,608 respondents to Health Information National Trends Survey-Cycle 4 2014 were analyzed...
May 25, 2017: Health Communication
https://www.readbyqxmd.com/read/28541509/evidence-that-phosphorylated-ubiquitin-signaling-is-involved-in-the-etiology-of-parkinson-s-disease
#5
Kahori Shiba-Fukushima, Kei-Ichi Ishikawa, Tsuyoshi Inoshita, Nana Izawa, Masashi Takanashi, Shigeto Sato, Osamu Onodera, Wado Akamatsu, Hideyuki Okano, Yuzuru Imai, Nobutaka Hattori
The ubiquitin (Ub) kinase PINK1 and the E3 Ub ligase Parkin, two gene products associated with young-onset Parkinson's disease (PD), participate in mitochondrial quality control. The phosphorylation of mitochondrial polyUb by PINK1, which is activated in a mitochondrial membrane potential (ΔΨm)-dependent manner, facilitates the mitochondrial translocation and concomitant enzymatic activation of Parkin, leading to the clearance of phospho-polyUb-tagged mitochondria via mitophagy. Thus, Ub phosphorylation is a key event in PINK1-Parkin-mediated mitophagy...
May 25, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28541286/impaired-prosaposin-lysosomal-trafficking-in-frontotemporal-lobar-degeneration-due-to-progranulin-mutations
#6
Xiaolai Zhou, Lirong Sun, Oliver Bracko, Ji Whae Choi, Yan Jia, Alissa L Nana, Owen Adam Brady, Jean C Cruz Hernandez, Nozomi Nishimura, William W Seeley, Fenghua Hu
Haploinsufficiency of progranulin (PGRN) due to mutations in the granulin (GRN) gene causes frontotemporal lobar degeneration (FTLD), and complete loss of PGRN leads to a lysosomal storage disorder, neuronal ceroid lipofuscinosis (NCL). Accumulating evidence suggests that PGRN is essential for proper lysosomal function, but the precise mechanisms involved are not known. Here, we show that PGRN facilitates neuronal uptake and lysosomal delivery of prosaposin (PSAP), the precursor of saposin peptides that are essential for lysosomal glycosphingolipid degradation...
May 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28539369/diagnosing-a-painful-abdominal-hernia
#7
Navraj S Nagra, Maxime P Cox, Gael R Nana, Jenny Isherwood
No abstract text is available yet for this article.
June 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28538406/dexmedetomidine-based-intravenous-anesthesia-of-a-pediatric-patient-with-glucose-6-phosphate-dehydrogenase-g6pd-deficiency-a-case-report
#8
Nanae Takahashi, Takashi Ogawa, Zen'ichiro Wajima, Akibumi Omi
RATIONALE: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect, resulting in deficits in nicotinamide adenine dinucleotide phosphate production, an important intracellular antioxidant enzyme. G6PD-deficient subjects present with a susceptibility of erythrocytes to oxidative stress and hemolysis, and should avoid drugs or stressors that have oxidative actions. Dexmedetomidine is an anesthetic agent with antioxidant actions. PATIENT CONCERNS AND DIAGNOSES: A 5-year-old boy with G6PD deficiency...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28535906/the-effects-of-curcumin-on-proliferation-apoptosis-invasion-and-nedd4-expression-in-pancreatic-cancer
#9
Jingna Su, Xiuxia Zhou, Xuyuan Yin, Lixia Wang, Zhe Zhao, Yingying Hou, Nana Zheng, Jun Xia, Zhiwei Wang
Pancreatic cancer (PC) is one of the most fatal cancers worldwide. The incidence and death rates are still increasing for PC. Curcumin is the biologically active diarylheptanoid constituent of the spice turmeric, which exerts its anticancer properties in various human cancers including PC. In particular, accumulating evidence has proved that curcumin targets numerous therapeutically important proteins in cell signaling pathways. The neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4) is an E3 HECT ubiquitin ligase and is frequently over-expressed in various cancers...
May 20, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28535671/synergistic-effects-of-arginine-and-methyl-salicylate-on-alleviating-postharvest-disease-caused-by-botrysis-cinerea-in-tomato-fruit
#10
Xinhua Zhang, Dedong Min, Fujun Li, Nana Ji, Demei Meng, Ling Li
The effect of L-arginine (Arg, 1 mM) and methyl salicylate (MeSA, 0.05 mM) either separately or combined on gray mold caused by Botrytis cinerea in tomato fruit was investigated. The results showed that the application of Arg or MeSA alone could reduce gray mold and the combined treatment was more effective in inhibiting fungal decay during storage than each treatment separately. The combined treatment not only increased the activities of antioxidant enzymes such as superoxide dismutase, catalase and peroxidase, but also enhanced the gene expression levels of pathogenesis-related protein 1 and the activities of defense enzymes including phenylalanine ammonia-lyase, polyphenol oxidase, chitinase and β-1,3-glucanase during most of the storage periods, which were associated with lower disease incidence and disease index...
May 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28535045/bet-bromodomain-inhibitors-with-one-step-synthesis-discovered-from-virtual-screen
#11
Alex M Ayoub, Laura M L Hawk, Ryan J Herzig, Jiewei Jiang, Andrea J Wisniewski, Clifford T Gee, Peiliang Zhao, Jin-Yi Zhu, Norbert Berndt, Nana K Offei-Addo, Thomas G Scott, Jun Qi, James E Bradner, Timothy R Ward, Ernst Schönbrunn, Gunda I Georg, William C K Pomerantz
Chemical inhibition of epigenetic regulatory proteins BrdT and Brd4 is emerging as a promising therapeutic strategy in contraception, cancer, and heart disease. We report an easily synthesized dihydropyridopyrmidine pan-BET inhibitor scaffold, which was uncovered via a virtual screen followed by testing in a fluorescence anisotropy assay. Dihydropyridpyimidine 3 was subjected to further characterization and is highly selective for the BET family of bromodomains. Structure-activity relationship data and ligand deconstruction highlight the importance of the substitution of the uracil moiety for potency and selectivity...
May 23, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28534422/psychosocial-risk-factors-in-relation-to-other-cardiovascular-risk-factors-in-coronary-heart-disease-results-from-the-euroaspire-iv-survey-a-registry-from-the-european-society-of-cardiology
#12
Nana Pogosova, Kornelia Kotseva, Dirk De Bacquer, Roland von Känel, Delphine De Smedt, Jan Bruthans, Maryna Dolzhenko
Background Depression and anxiety are established psychosocial risk factors for coronary heart disease. Contemporary data on their prevalence and associations with other risk factors were evaluated as part of the EUROASPIRE IV survey. Design The design of this study was cross-sectional. Methods The study group consisted of 7589 patients from 24 European countries examined at a median of 1.4 years after hospitalisation due to coronary heart disease events. Depression and anxiety were assessed using the Hospital Anxiety and Depression Scale...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28533245/clonal-dissemination-of-oxa-232-carbapenenase-producing-klebsiella-pneumoniae-in-neonates
#13
Dandan Yin, Dong Dong, Ke Li, Lei Zhang, Jianliang Liang, Yang Yang, Nana Wu, Yiyan Bao, Chuanqing Wang, Fupin Hu
Five OXA-232 carbapenemase-producing Klebsiella pneumoniae were isolated from neonates, belonging to the pandemic clone ST15, and co-produced blaCTX-M-15 and blaSHV-1 genes. All isolates were resistant to ertapenem (MIC>32μg/mL) and meropenem (4-8μg/mL), susceptible or intermediate to impenem (1-2μg/mL). The blaOXA-232 was located on a ColE-type transformable plasmid of 6,141 bp. To our best knowledge, this is the first report of OXA-232 carbapenemase among clinical isolates in China.
May 22, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28530283/composite-cd-mof-nanocrystals-containing-microspheres-for-sustained-drug-delivery
#14
Haiyan Li, Nana Lv, Xue Li, Botao Liu, Jing Feng, Xiaohong Ren, Tao Guo, Dawei Chen, J Fraser Stoddart, Ruxandra Gref, Jiwen Zhang
Metal-organic frameworks (MOFs), which are typically embedded in polymer matrices as composites, are emerging as a new class of carriers for sustained drug delivery. Most of the MOFs and the polymers used so far in these composites, however, are not pharmaceutically acceptable. In the investigation reported herein, composites of γ-cyclodextrin (γ-CD)-based MOFs (CD-MOFs) and polyacrylic acid (PAA) were prepared by a solid in oil-in-oil (s/o/o) emulsifying solvent evaporation method. A modified hydrothermal protocol has been established which produces efficiently at 50 °C in 6 h micron (5-10 μm) and nanometer (500-700 nm) diameter CD-MOF particles of uniform size with smooth surfaces and powder X-ray diffraction patterns that are identical with those reported in the literature...
May 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28529922/governmental-efforts-for-cardiovascular-disease-prevention-efforts-in-the-russian-federation
#15
REVIEW
Nana Pogosova, Olga Sokolova
Cardiovascular disease (CVD) is the leading cause of death and disability in Russia as is case with the most other countries of the world, although Russia has unique features and demographic trends. In the late 90's and early 2000's Russia has sustained a profound demographical crisis with a period of overmortality but since 2003 the mortality rates are declining. By 2013, the birth rates exceeded mortality. The reversal of the demographic crisis took place on the background of a number of comprehensive governmental efforts with focus on non-communicable diseases prevention...
April 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28529264/communities-of-putative-ericoid-mycorrhizal-fungi-isolated-from-alpine-dwarf-shrubs-in-japan-effects-of-host-identity-and-microhabitat
#16
Takahiko Koizumi, Kazuhide Nara
Dwarf shrubs of the family Ericaceae are common in arctic and alpine regions. Many of these plants are associated with ericoid mycorrhizal (ERM) fungi, which allow them to take nutrients and water from the soil under harsh environmental conditions and, thus, affect host plant survival. Despite the importance of ERM fungi to alpine plant communities, limited information is available on the effects of microhabitat and host identity on ERM fungal communities. We investigated the communities of putative ERM fungi isolated from five dwarf shrub species (Arcterica nana, Diapensia lapponica, Empetrum nigrum, Loiseleuria procumbens, and Vaccinium vitis-idaea) that co-occur in an alpine region of Japan, with reference to distinct microhabitats provided by large stone pine (Pinus pumila) shrubs (i...
May 20, 2017: Microbes and Environments
https://www.readbyqxmd.com/read/28521862/bile-acid-binding-resin-prevents-fat-accumulation-through-intestinal-microbiota-in-high-fat-diet-induced-obesity-in-mice
#17
Yukie Kusumoto, Junichiro Irie, Kaho Iwabu, Hirotsune Tagawa, Arata Itoh, Mari Kato, Nana Kobayashi, Kumiko Tanaka, Rieko Kikuchi, Masataka Fujita, Yuya Nakajima, Kohkichi Morimoto, Taichi Sugizaki, Satoru Yamada, Toshihide Kawai, Mitsuhiro Watanabe, Yuichi Oike, Hiroshi Itoh
BACKGROUND: Bile acid binding resin (BAR) absorbs intestinal bile acids, and improves obesity and metabolic disorders, but the precise mechanism remains to be clarified. Recent findings reveal that obesity is associated with skewed intestinal microbiota. Thus, we investigated the effect of BAR on intestinal microbiota and the role of microbiota in the prevention of obesity in high-fat diet-induced obesity in mice. PROCEDURES: Male Balb/c mice were fed a low-fat diet (LFD), high-fat diet (HFD), or HFD with BAR (HFD+BAR), and then metabolic parameters, caecal microbiota, and metabolites were investigated...
June 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28521219/antifouling-zwitterionic-hydrogel-coating-improves-hemocompatibility-of-activated-carbon-hemoadsorbent
#18
Nana Cai, Qingsi Li, Jiamin Zhang, Tong Xu, Weiqiang Zhao, Jing Yang, Lei Zhang
Activated carbon has been widely used in hemoperfusion treatments. However, its performance has been significantly compromised by their poor hemocompatibility. In this work, we developed a novel antifouling adsorbent based on zwitterionic poly-carboxybetaine (PCB) hydrogel and powdered activated carbon (PAC) to improve hemocompatibility. We found this new adsorbent (PCB-PAC) was highly stable with negligible leakage of activated carbon debris. It could efficiently resist protein adsorption and avoid any hemolysis effect...
April 20, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28518139/mir-106b-and-mir-93-regulate-cell-progression-by-suppression-of-pten-via-pi3k-akt-pathway-in-breast-cancer
#19
Nana Li, Yuan Miao, Yujia Shan, Bing Liu, Yang Li, Lifen Zhao, Li Jia
Accumulating evidences have revealed that dysregulated microRNAs (miRNAs) involve in the tumorigenesis, progression and even lead to poor prognosis of various carcinomas, including breast cancer. MiRNA-106b-5p (miR-106b) and miRNA-93-5p (miR-93) levels were confirmed to be significantly upregulated in breast cancer clinical samples (n=36) and metastatic cell line (MDA-MB-231) compared with those in the paired adjacent tissues and normal breast epithelial cell line (MCF-10A). Moreover, further research stated that the capability of migration, invasion and proliferation changed along with the altered expression of miR-106b and miR-93 in breast cancer...
May 18, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28516766/in-situ-generated-tempo-oxoammonium-salt-mediated-tandem-cyclization-of-%C3%AE-oxoamides-with-amine-hydrochlorides-for-the-synthesis-of-pyrrolin-4-ones
#20
Xuna Zhao, Tong-Xin Liu, Nana Ma, Guisheng Zhang
A novel in situ generated TEMPO oxoammonium salt mediated one-pot tandem reaction has been developed for the straightforward construction of pyrrolin-4-ones from readily available β-oxoamides with amine hydrochlorides. The reaction tolerates various functional groups and represents a reliable method for the synthesis of highly substituted pyrrolin-4-ones in good yields under mild conditions. Detailed mechanistic studies disclosed that TEMPO oxoammonium salt generated in situ was crucial for the transformation involving the formation of enaminone precursors in situ by condensation of the β-oxoamides with amines, followed by sequential oxidative coupling with β-oxoamides, intramolecular cyclization, and 1,2-alkyl migration steps...
May 24, 2017: Journal of Organic Chemistry
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