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https://www.readbyqxmd.com/read/28340062/exogenously-applied-24-epibrassinolide-ebl-ameliorates-detrimental-effects-of-salinity-by-reducing-k-efflux-via-depolarization-activated-k-channels
#1
Nazila Azhar, Nana Su, Lana Shabala, Sergey Shabala
This study has investigated mechanisms conferring beneficial effects of exogenous application of 24-epibrassinolides (EBL) on plant growth and performance under saline conditions. Barley seedlings treated with 0.25 mg l-1 EBL showed significant improvements in root hair length, shoot length, shoot fresh weight and relative water content when grown in the presence of 150 mM NaCl in the growth medium. In addition, EBL treatment significantly decreased the Na+ content in both shoots (by approximately 50%) and roots...
March 2, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28339017/sirt1-is-required-for-mitochondrial-biogenesis-reprogramming-in-hypoxic-human-pulmonary-arteriolar-smooth-muscle-cells
#2
Pengyun Li, Yan Liu, Nana Burns, Ke-Seng Zhao, Rui Song
Although recent studies have reported that mitochondria are putative oxygen sensors underlying hypoxic pulmonary vasoconstriction, little is known concerning the sirtuin 1 (SIRT1)-mediated mitochondrial biogenesis regulatory program in pulmonary arteriolar smooth muscle cells (PASMCs) during hypoxia/reoxygenation (H/R). We investigated the epigenetic regulatory mechanism of mitochondrial biogenesis and function in human PASMCs during H/R. Human PASMCs were exposed to hypoxia of 24-48 h and reoxygenation of 24-48 h...
March 22, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28338764/fruit-and-vegetable-intake-and-the-risk-of-cardiovascular-disease-total-cancer-and-all-cause-mortality-a-systematic-review-and-dose-response-meta-analysis-of-prospective-studies
#3
Dagfinn Aune, Edward Giovannucci, Paolo Boffetta, Lars T Fadnes, NaNa Keum, Teresa Norat, Darren C Greenwood, Elio Riboli, Lars J Vatten, Serena Tonstad
Background: Questions remain about the strength and shape of the dose-response relationship between fruit and vegetable intake and risk of cardiovascular disease, cancer and mortality, and the effects of specific types of fruit and vegetables. We conducted a systematic review and meta-analysis to clarify these associations. Methods: PubMed and Embase were searched up to 29 September 2016. Prospective studies of fruit and vegetable intake and cardiovascular disease, total cancer and all-cause mortality were included...
February 22, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28336277/structure-characteristics-of-an-acidic-polysaccharide-purified-from-banana-musa-nana-lour-pulp-and-its-enzymatic-degradation
#4
Huiling Liu, Yueming Jiang, Hongshun Yang, Bao Yang
Banana is one of the most important fruits over the world. The chemical composition is critical for the organoleptic properties and health benefits. As one of the leading bioactive components in banana pulp, the polysaccharides may contribute to the beneficial health effects. However, their precise structure information remains unknown. A leading acidic polysaccharide (ABPP) of banana pulp was purified and identified by nuclear magnetic resonnance spectroscopy (NMR) and gas chromatography-mass spectrometry (GC-MS)...
March 20, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28335005/tdp-43-suppresses-tau-expression-via-promoting-its-mrna-instability
#5
Jianlan Gu, Feng Wu, Wen Xu, Jianhua Shi, Wen Hu, Nana Jin, Wei Qian, Xinglong Wang, Khalid Iqbal, Cheng-Xin Gong, Fei Liu
In the brains of individuals with Alzheimer's disease (AD) and chronic traumatic encephalopathy, tau pathology is accompanied usually by intracellular aggregation of transactive response DNA-binding protein 43 (TDP-43). However, the role of TDP-43 in tau pathogenesis is not understood. Here, we investigated the role of TDP-43 in tau expression in vitro and in vivo. We found that TDP-43 suppressed tau expression by promoting its mRNA instability through the UG repeats of its 3΄-untranslated region (3΄-UTR)...
March 15, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28334275/identification-of-a-novel-bzip-transcription-factor-in-camellia-sinensis-as-a-negative-regulator-of-freezing-tolerance-in-transgenic-arabidopsis
#6
Lu Wang, Hongli Cao, Wenjun Qian, Lina Yao, Xinyuan Hao, Nana Li, Yajun Yang, Xinchao Wang
Background and Aims: Basic region/leucine zipper (bZIP) transcription factors play vital roles in the abiotic stress response of plants. However, little is known about the function of bZIP genes in Camellia sinensis . Methods: CsbZIP6 was overexpressed in Arabidopsis thaliana . Effects of CsbZIP6 overexpression on abscisic acid (ABA) sensitivity, freezing tolerance and the expression of cold-responsive genes in arabidopsis were studied. Key Results: CsbZIP6 was induced during cold acclimation in tea plant...
March 14, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28333930/fifteen-years-of-programme-implementation-for-the-elimination-of-lymphatic-filariasis-in-ghana-impact-of-mda-on-immunoparasitological-indicators
#7
Nana-Kwadwo Biritwum, Dziedzom K de Souza, Benjamin Marfo, Samuel Odoom, Bright Alomatu, Odame Asiedu, Abednego Yeboah, Tei E Hervie, Ernest O Mensah, Paul Yikpotey, Joseph B Koroma, David Molyneux, Moses J Bockarie, John O Gyapong
No abstract text is available yet for this article.
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28331781/single-crystalline-ultrathin-nickel-cobalt-alloy-nanosheets-array-for-direct-hydrazine-fuel-cells
#8
Guang Feng, Yun Kuang, Pengsong Li, Nana Han, Ming Sun, Guoxin Zhang, Xiaoming Sun
Ultrathin 2D metal alloy nanomaterials have great potential applications but their controlled syntheses are limited to few noble metal based systems. Herein Ni x Co1-x alloy nanosheets with ultrathin (sub-3 nm) single-crystalline 2D structure are synthesized through a topochemical reduction method. Moreover, the optimized composition Ni0.6Co0.4 alloy nanosheets array exhibits excellent performances for hydrazine oxidation reaction and direct hydrazine fuel cells.
March 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28329681/sirt6-promotes-dna-end-joining-in-ipscs-derived-from-old-mice
#9
Wen Chen, Nana Liu, Hongxia Zhang, Haiping Zhang, Jing Qiao, Wenwen Jia, Songcheng Zhu, Zhiyong Mao, Jiuhong Kang
Induced pluripotent stem cells (iPSCs) have great potential for treating age-related diseases, but the genome integrity of iPSCs is critically important. Here, we demonstrate that non-homologous end joining (NHEJ), rather than homologous recombination (HR), is less efficient in iPSCs from old mice than young mice. We further find that Sirt6 is downregulated in iPSCs from old mice. Sirt6 directly binds to Ku80 and facilitates the Ku80/DNA-PKcs interaction, thus promoting DNA-PKcs phosphorylation at residue S2056, leading to efficient NHEJ...
March 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/28328141/a-590-kb-deletion-caused-by-non-allelic-homologous-recombination-between-two-line-1-elements-in-a-patient-with-mesomelia-synostosis-syndrome
#10
Tomohiro Kohmoto, Takuya Naruto, Miki Watanabe, Yuji Fujita, Sae Ujiro, Nana Okamoto, Hideaki Horikawa, Kiyoshi Masuda, Issei Imoto
Mesomelia-synostoses syndrome (MSS) is a rare, autosomal-dominant, syndromal osteochondrodysplasia characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations due to a non-recurrent deletion at 8q13 that always encompasses two coding-genes, SULF1 and SLCO5A1. To date, five unrelated patients have been reported worldwide, and MMS was previously proposed to not be a genomic disorder associated with deletions recurring from non-allelic homologous recombination (NAHR) in at least two analyzed cases...
April 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28317968/ag-induced-photoluminescence-enhancement-in-lanthanide-post-functionalized-mofs-and-ag-sensing
#11
Nana Sun, Bing Yan
The robust gallium carboxylate Ga(OH)(btec)·0.5H2O (MIL-61) is selected as a parent MOF to prepare Ln-MIL-61 by PSM. This work investigates the luminescence of Ln-doped MIL-61 (Ln = Eu(3+), Tb(3+), Sm(3+), Dy(3+)) in the visible light region. Upon 314 nm excitation, the emission spectra of Eu-MIL-61, Tb-MIL-61 and Eu/Tb-MIL-61 all exhibit their respective strong sharp emission bands. However, Sm-MIL-61 and Dy-MIL-61 show very similar emission to MIL-61 and almost no luminescence of Sm(3+) and Dy(3+). In this work, the weak fluorescence of Sm(3+) or Dy(3+) doped MIL-61 is effectively sensitized by Ag(+)...
March 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28317801/utility-of-quantiferon-tuberculosis-gold-in-tube-test-for-detecting-latent-tuberculosis-infection-among-close-household-contacts-of-confirmed-tuberculosis-patients-in-accra-ghana
#12
Gloria Ivy Mensah, Sandra Akoley Sowah, Nana Yaw Asare Yeboah, Kennedy Kwasi Addo, Dolly Jackson-Sillah
OBJECTIVE/BACKGROUND: Introduction of the interferon gamma (IFN-γ) release assays with their higher sensitivity and specificity over the traditional tuberculin skin test has improved testing for latent tuberculosis infection (LTBI). None of the IFN-γ release assays has ever been used to screen for LTBI in Ghana. This study set out to determine the utility of the QuantiFERON TB Gold-in-Tube (QFT-GIT) test for the diagnosis of LTBI among close household contacts of newly diagnosed sputum smear-positive tuberculosis (TB) patents in Accra, Ghana, and the associated risk factors for a positive QFT-GIT test...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28315771/evidence-for-two-populations-of-hair-bundles-in-the-sea-anemone-nematostella-vectensis
#13
Shelcie S Menard, Glen M Watson
Cytochalasin D (CD) was employed to disrupt F-actin within stereocilia of anemone hair bundles. CD treatment decreases the abundance of hair bundles (by 85%) while significantly impairing predation. The remaining hair bundles are 'CD-resistant.' Surprisingly, the morphology and F-actin content of resistant hair bundles are comparable to those of untreated controls. However, the resistant hair bundles fail to respond normally to the N-acetylated sugar, NANA, by elongating. Instead, they remain at resting length...
March 16, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28298691/the-effective-and-selective-separation-of-epigallocatechin-gallate-by-molecularly-imprinted-chitosan-beads
#14
Xueqing Yu, Yingjun Jing, Nana Yin
The (-)-epigallocatechin gallate (EGCG) imprinted chitosan beads (EICBs) were fabricated for the effective and selective separation of EGCG. The EGCG molecules interacted with the amino groups of chitosan in the imprinting process, resulting in a highly porous structure of EICBs and more adsorption sites. Consequently, EICBs exhibited better adsorption performance than non-imprinted chitosan beads. The maximum adsorption capacity of EGCG onto EICBs reached 135.50 mg/g at 313 K. The imprinting factor of EICBs was 4...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28298363/mutual-interaction-between-endothelial-cells-and-mural-cells-enhances-bmp9-signaling-in-endothelial-cells
#15
Yuki Tachida, Nanae Izumi, Toyo Sakurai, Hideki Kobayashi
Hereditary hemorrhagic telangiectasia is characterized by the formation of abnormal vascular networks and caused by the mutation of genes involved in BMP9 signaling. It is also known that the interaction between endothelial cells (ECs) and mural cells (MCs) is critical to maintain vessel integrity. However, it has not yet fully been uncovered whether the EC-MC interaction affects BMP9 signaling or not. To elucidate this point, we analyzed BMP9 signaling in a co-culture of several types of human primary culture ECs and MCs...
March 15, 2017: Biology Open
https://www.readbyqxmd.com/read/28296270/analogues-of-dehydroacetic-acid-as-selective-and-potent-agonists-of-an-ectopic-odorant-receptor-through-a-combination-of-hydrophilic-and-hydrophobic-interactions
#16
Bernie Byunghoon Park, NaHye Lee, YunHye Kim, YoonGyu Jae, Seunghyun Choi, NaNa Kang, Yu Ri Hong, Kiwon Ok, Jeonghee Cho, Young Ho Jeon, Eun Hee Lee, Youngjoo Byun, JaeHyung Koo
Identification of potent agonists of odorant receptors (ORs), a major class of G protein-coupled receptors, remains challenging due to complex receptor-ligand interactions. ORs are present in both olfactory and non-chemosensory tissues, indicating roles beyond odor detection that may include modulating physiological functions in non-olfactory tissues. Selective and potent agonists specific for particular ORs can be used to investigate physiological functions of ORs in non-chemosensory tissues. In this study, we designed and synthesized novel synthetic dehydroacetic acid analogues as agonists of odorant receptor 895 (Olfr895) expressed in bladder...
March 15, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28295378/calcium-control-of-the-sign-of-phototaxis-in-brown-algal-gametes-of-mutimo-cylindricus
#17
Nana Kinoshita, Chikako Nagasato, Taizo Motomura
Brown algal swarmers usually exhibit positive or negative phototaxis. Such behaviours influence the increasing or decreasing dispersal distance or colonization on the new substratum. We confirmed that the sign of phototaxis (negative or positive) in male gametes of Mutimo cylindricus was affected by extracellular Ca(2+) influx through Ca(2+) channels. Under the control condition (10(-2) M [Ca(2+) ]), male gametes swimming with a helical rotation of their cell body mostly showed positive phototaxis. At 10(-3) M [Ca(2+) ], more than half of the male gametes showed positive phototaxis, whereas the others showed negative phototaxis...
March 15, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28287085/dynamic-transcriptomes-identify-biogenic-amines-and-insect-like-hormonal-regulation-for-mediating-reproduction-in-schistosoma-japonicum
#18
Jipeng Wang, Ying Yu, Haimo Shen, Tao Qing, Yuanting Zheng, Qing Li, Xiaojin Mo, Shuqi Wang, Nana Li, Riyi Chai, Bin Xu, Mu Liu, Paul J Brindley, Donald P McManus, Zheng Feng, Leming Shi, Wei Hu
Eggs produced by the mature female parasite are responsible for the pathogenesis and transmission of schistosomiasis. Female schistosomes rely on a unique male-induced strategy to accomplish reproductive development, a process that is incompletely understood. Here we map detailed transcriptomic profiles of male and female Schistosoma japonicum across eight time points throughout the sexual developmental process from pairing to maturation. The dynamic gene expression pattern data reveal clear sex-related characteristics, indicative of an unambiguous functional division between males and females during their interplay...
March 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28286512/optimization-of-agrobacterium-mediated-transformation-in-soybean
#19
Shuxuan Li, Yahui Cong, Yaping Liu, Tingting Wang, Qin Shuai, Nana Chen, Junyi Gai, Yan Li
High transformation efficiency is a prerequisite for study of gene function and molecular breeding. Agrobacterium tumefaciens-mediated transformation is a preferred method in many plants. However, the transformation efficiency in soybean is still low. The objective of this study is to optimize Agrobacterium-mediated transformation in soybean by improving the infection efficiency of Agrobacterium and regeneration efficiency of explants. Firstly, four factors affecting Agrobacterium infection efficiency were investigated by estimation of the rate of GUS transient expression in soybean cotyledonary explants, including Agrobacterium concentrations, soybean explants, Agrobacterium suspension medium, and co-cultivation time...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28283003/bacterial-magnetic-particles-improve-testes-mediated-transgene-efficiency-in-mice
#20
COMPARATIVE STUDY
Chao Wang, Guanghong Sun, Ye Wang, Nana Kong, Yafei Chi, Leilei Yang, Qiliang Xin, Zhen Teng, Xu Wang, Yujun Wen, Ying Li, Guoliang Xia
Nano-scaled materials have been proved to be ideal DNA carriers for transgene. Bacterial magnetic particles (BMPs) help to reduce the toxicity of polyethylenimine (PEI), an efficient gene-transferring agent, and assist tissue transgene ex vivo. Here, the effectiveness of the BMP-PEI complex-conjugated foreign DNAs (BPDs) in promoting testes-mediated gene transfer (TMGT) in mouse was compared with that of liposome-conjugated foreign DNAs. The results proved that through testes injection, the clusters of BPDs successfully reached the cytoplasm and the nuclear of spermatogenesis cell, and expressed in testes of transgene founder mice...
November 2017: Drug Delivery
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