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https://www.readbyqxmd.com/read/28734225/adverse-effects-of-methylmercury-mehg-on-life-parameters-antioxidant-systems-and-mapk-signaling-pathways-in-the-rotifer-brachionus-koreanus-and-the-copepod-paracyclopina-nana
#1
Young Hwan Lee, Duck-Hyun Kim, Hye-Min Kang, Minghua Wang, Chang-Bum Jeong, Jae-Seong Lee
To evaluate the adverse effects of MeHg on the rotifer Brachionus koreanus and the copepod Paracyclopina nana, we assessed the effects of MeHg toxicity on life parameters (e.g. growth retardation and fecundity), antioxidant systems, and mitogen-activated protein kinase (MAPK) signaling pathways at various concentrations (1ng/L, 10ng/L, 100ng/L, 500ng/L, and 1000ng/L). MeHg exposure resulted in the growth retardation with the increased ROS levels but decreased glutathione (GSH) levels in a dose-dependent manner in both B...
July 12, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28729821/optimized-model-of-cerebral-ischemia-in-situ-for-the-long-lasting-assessment-of-hippocampal-cell-death
#2
Oksana Rybachuk, Olga Kopach, Volodymyr Krotov, Nana Voitenko, Tatyana Pivneva
Among all the brain, the hippocampus is the most susceptible region to ischemic lesion, with the highest vulnerability of CA1 pyramidal neurons to ischemic damage. This damage may cause either prompt neuronal death (within hours) or with a delayed appearance (over days), providing a window for applying potential therapies to reduce or prevent ischemic impairments. However, the time course when ischemic damage turns to neuronal death strictly depends on experimental modeling of cerebral ischemia and, up to now, studies were predominantly focused on a short time-window-from hours to up to a few days post-lesion...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28727761/genome-wide-identification-of-the-potato-wrky-transcription-factor-family
#3
Chao Zhang, Dongdong Wang, Chenghui Yang, Nana Kong, Zheng Shi, Peng Zhao, Yunyou Nan, Tengkun Nie, Ruoqiu Wang, Haoli Ma, Qin Chen
WRKY transcription factors play pivotal roles in regulation of stress responses. This study identified 79 WRKY genes in potato (Solanum tuberosum). Based on multiple sequence alignment and phylogenetic relationships, WRKY genes were classified into three major groups. The majority of WRKY genes belonged to Group II (52 StWRKYs), Group III had 14 and Group I consisted of 13. The phylogenetic tree further classified Group II into five sub-groups. All StWRKY genes except StWRKY79 were mapped on potato chromosomes, with eight tandem duplication gene pairs and seven segmental duplication gene pairs found from StWRKY family genes...
2017: PloS One
https://www.readbyqxmd.com/read/28726529/factors-associated-with-the-elevated-percentage-of-cd4cd69-t-cells-in-maintained-hemodialysis-patients
#4
Rongyi Chen, Fangfang Xiang, Jiachang Hu, Xuesen Cao, Xiao Tan, Ping Jia, Ting Zhang, Nana Song, Yi Fang, Xiaoqiang Ding, Jianzhou Zou
BACKGROUND: CD4 T-cell abnormality, influencing the outcome of the maintained hemodialysis (MHD), is common in patients on dialysis. We try to find out factors associated with the activated CD4 T cells, CD4CD69 T cells, to improve the dialysis quality. METHODS: A cross-sectional study was conducted to evaluate the change of CD4CD69 in MHD patients and healthy controls in our hospital from September 2015 to May 2016. A total of 164 MHD patients and 24 healthy controls were included according to the criteria...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28725170/helicobacter-pylori-infection-status-had-no-influence-on-upper-gastrointestinal-symptoms-a-cross-sectional-analysis-of-3-005-japanese-subjects-without-upper-gastrointestinal-lesions-undergoing-medical-health-checkups
#5
Tomomi Yoshioka, Eri Takeshita, Yasuhisa Sakata, Megumi Hara, Kayo Akutagawa, Natsuko Sakata, Hiroyoshi Endo, Takashi Ohyama, Keiji Matsunaga, Yuichiro Tanaka, Shinpei Shirai, Yoichiro Ito, Nanae Tsuruoka, Ryuichi Iwakiri, Motoyasu Kusano, Kazuma Fujimoto
BACKGROUND: This study aimed to evaluate the influence of Helicobacter pylori infection and its eradication on the upper gastrointestinal symptoms of relatively healthy Japanese subjects. METHODS: A total of 3,005 subjects (male/female: 1,549/1,456) undergoing medical health checkups were enrolled in the present study, at five hospitals in Saga, Japan, from January to December 2013. They had no significant findings following upper gastrointestinal endoscopy. All subjects completed a questionnaire that addressed a frequency scale for symptoms of gastroesophageal reflux disease...
2017: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/28724992/opposite-bidirectional-shifts-in-excitation-and-inhibition-in-specific-types-of-dorsal-horn-interneurons-are-associated-with-spasticity-and-pain-post-sci
#6
Olga Kopach, Volodymyr Medvediev, Volodymyr Krotov, Anya Borisyuk, Vitaliy Tsymbaliuk, Nana Voitenko
Spasticity, a common complication after spinal cord injury (SCI), is frequently accompanied by chronic pain. The physiological origin of this pain (critical to its treatment) remains unknown, although spastic motor dysfunction has been related to the hyperexcitability of motoneurons and to changes in spinal sensory processing. Here we show that the pain mechanism involves changes in sensory circuits of the dorsal horn (DH) where nociceptive inputs integrate for pain processing. Spasticity is associated with the DH hyperexcitability resulting from an increase in excitation and disinhibition occurring in two respective types of sensory interneurons...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28723691/high-cost-of-hospitalization-for-colonic-diverticular-bleeding-depended-on-repeated-bleeding-and-blood-transfusion-analysis-with-diagnosis-procedure-combination-data-in-japan
#7
Yoichiro Ito, Yasuhisa Sakata, Hisako Yoshida, Sayuri Nonaka, Susumu Fujii, Yuichiro Tanaka, Shimpei Shirai, Eri Takeshita, Takashi Akutagawa, Hiroharu Kawakubo, Koji Yamamoto, Nanae Tsuruoka, Ryo Shimoda, Ryuichi Iwakiri, Kazuma Fujimoto
BACKGROUND: Bleeding from a colonic diverticulum is serious in aged patients. The aim of this study was to determine the risk factors for high-cost hospitalization of colonic diverticular bleeding using the diagnosis procedure combination (DPC) data. METHODS: From January 2009 to December 2015, 78 patients with colonic diverticular bleeding were identified by DPC data in Saga Medical School Hospital. All patients underwent colonic endoscopy within 3 days. The patients were divided into 2 groups: the low-cost group (DPC cost of <500,000 yen) and the high-cost group (DPC cost of >500,000 yen)...
July 20, 2017: Digestion
https://www.readbyqxmd.com/read/28723653/inhibition-of-notch-1-pathway-is-involved-in-rottlerin-induced-tumor-suppressive-function-in-nasopharyngeal-carcinoma-cells
#8
Yingying Hou, Shaoyan Feng, Lixia Wang, Zhe Zhao, Jingna Su, Xuyuan Yin, Nana Zheng, Xiuxia Zhou, Jun Xia, Zhiwei Wang
Recent studies have revealed that rottlerin is a natural chemical drug to exert its anti-cancer activity. However, the molecular mechanisms of rottlerin-induced tumor suppressive function have not been fully elucidated. Notch signaling pathway has been characterized to play a crucial role in tumorigenesis. Therefore, regulation of Notch pathway could be beneficial for the treatment of human cancer. The aims of our current study were to explore whether rottlerin could suppress Notch-1 expression, which leads to inhibition of cell proliferation, migration and invasion in nasopharyngeal carcinoma cells...
July 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28719963/prevalence-of-hymenolepis-nana-and-h-diminuta-from-brown-rats-rattus-norvegicus-in-heilongjiang-province-china
#9
Di Yang, Wei Zhao, Yichi Zhang, Aiqin Liu
Hymenolepis nana and Hymenolepis diminuta are globally widespread zoonotic cestodes. Rodents are the main reservoir host of these cestodes. Brown rats (Rattus norvegicus) are the best known and most common rats, and usually live wherever humans live, especially in less than desirable hygiene conditions. Due to the little information of the 2 hymenolepidid species in brown rats in China, the aim of this study was to understand the prevalence and genetic characterization of H. nana and H. diminuta in brown rats in Heilongjiang Province, China...
June 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28719925/acetylated-furostene-glycosides-from-solanum-gilo-fruits
#10
Edwige Nana Tchoupang, Christina Reder, Sylvin Benjamin Ateba, Martin Zehl, Hanspeter Kählig, Dieudonné Njamen, Franziska Höller, Sabine Glasl-Tazreiter, Liselotte Krenn
In continuation of our work on a traditional mixture of spices called "Nkui", used in Cameroon for its influence on women's reproductive health, we investigated the chemical composition of Solanum gilo, one component of "Nkui". A methanolic extract was studied in detail. After dereplication of several known compounds, two furo-5-stene-derived saponin glycosides with acetylated sugar moieties were isolated. By extensive 1- and 2D NMR experiments and HR-MS and GC-MS methods, the structures were elucidated as 26-[(3‴,4‴,6‴-tri-O-acetyl)-β-D-glucopyranosyloxy]-22-hydroxyfurost-5-en-3β-yl-O-α-L-rhamnopyranosyl-(1″→2')-β-D-glucopyranoside (A) and 26-[(3‴,4‴,6‴-tri-O-acetyl)-β-D-glucopyranosyloxy]-22-hydroxyfurost-5-en-3β-yl-[O-α-L-rhamnopyranosyl-(1''''→4')-O-α-L-rhamnopyranosyl-(1″→2')]-β-D-glucopyranoside (B), both new natural compounds...
July 18, 2017: Planta Medica
https://www.readbyqxmd.com/read/28719563/what-s-new-in-musculoskeletal-infection-update-across-orthopaedic-subspecialties
#11
Antonia F Chen, Arvind D Nana, Sandra B Nelson, Alex McLaren
No abstract text is available yet for this article.
July 19, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28715885/the-effects-of-exercise-and-cold-exposure-on-mitochondrial-biogenesis-in-skeletal-muscle-and-white-adipose-tissue
#12
Nana Chung, Jonghoon Park, Kiwon Lim
PURPOSE: The purpose of this study was to determine whether exercise or/and cold exposure regulate mitochondria biogenesis-related gene expression in soleus and inguinal adipose tissue of mice. METHODS: Forty ICR 5-week old male mice were divided into four groups: thermoneutrality-untrained (23 ± 1 °C in room temperature, n=10), cold-water immersion (24 ± 1 °C, n=10), exercise in neutral temperature (34 ± 1 °C, n=10), and exercise in cold temperature (24 ± 1 °C, n=10)...
June 30, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28715884/association-of-daily-physical-activity-level-with-health-related-factors-by-gender-and-age-specific-differences-among-korean-adults-based-on-the-sixth-2014-2015-korea-national-health-and-nutrition-examination-survey
#13
Nana Chung, Hun-Young Park, Mi-Young Park, Yoon-Young Hwang, Chi-Ho Lee, Jin-Soo Han, Jaemoo So, Jisu Kim, Jonghoon Park, Kiwon Lim
PURPOSE: This study examined the effects of daily physical activity level on health-related factors according to gender and identified age-specific differences among Korean adults. METHODS: Using data from the Korea National Health and Nutrition Examination Survey VI (2014-2015), we selected adults aged 19-64 years who participated in both a health examination and health interview survey. The study included 6,457 participants 19-64 years of age (2,611 men, 3,846 women)...
June 30, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28713962/bioinformatics-analysis-of-key-genes-and-signaling-pathways-associated-with-myocardial-infarction-following-telomerase-activation
#14
Yi Yang, Guang Yang, Hongwei Du, Nana Dong, Bo Yu
The present study aimed to identify key genes and signaling pathways associated with myocardial infarction (MI) following telomerase activation, and investigate the possible underlying molecular mechanisms involved in this process. Array data of GSE62973 was downloaded, including 11 samples from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were analyzed in infarct vs. control, infarct + telomerase vs. control, and infarct + telomerase vs. infarct with the Linear Models for Microarray and RNA‑Seq Data package...
July 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28713205/khf2-a-mild-and-selective-desilylating-agent-for-phenol-t-butyldimethylsilyl-tbdms-ethers
#15
Mahesh K Lakshman, Fatou A Tine, Tashrique A Khandaker, Vikram Basava, Nana B Agyemang, Michael S A Benavidez, Marikone Gaši, Lisa Guerrera, Barbara Zajc
TBDMS (t-BuMe2Si, t-butyldimethylsilyl) ethers of a variety of phenols have been deprotected with KHF2 in MeOH, at room temperature. Carboxylic ester and labile phenolic acetate were unaffected under these conditions. In competition reactions between TBDMS ethers of a phenol and two primary benzylic alcohols, the phenolic ether underwent cleavage whereas the alcohol ethers remained intact. From a substrate containing both a phenolic hydroxyl group and a secondary, doubly benzylic hydroxyl group protected as TBDMS ethers, the phenol was rapidly and selectively released...
March 2017: Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry
https://www.readbyqxmd.com/read/28711437/intestinal-parasitic-infections-current-status-and-associated-risk-factors-among-school-aged-children-in-an-archetypal-african-urban-slum-in-nigeria
#16
Vincent P Gyang, Ting-Wu Chuang, Chien-Wei Liao, Yueh-Lun Lee, Olaoluwa P Akinwale, Akwaowo Orok, Olusola Ajibaye, Ajayi J Babasola, Po-Ching Cheng, Chia-Mei Chou, Ying-Chieh Huang, Pasaiko Sonko, Chia-Kwung Fan
BACKGROUND/PURPOSE: Intestinal parasitic infections (IPIs) among school aged children (SAC) in Nigeria remains endemic, hence the need for regular surveillance to attract the attention of policy makers. This cross-sectional study investigated the current prevalence and factors associated with intestinal parasitic infections among school aged children in an urban slum of Lagos City, Nigeria. METHODS: Single stool samples from 384 school aged children (188 boys and 196 girls) were examined by employing Merthiolate-iodine-formaldehyde concentration (MIFC) and Kato-Katz methods...
June 22, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28706305/pressure-induced-crystallization-and-phase-transformation-of-para-xylene
#17
Yanzhi Bai, Zhenhai Yu, Ran Liu, Nana Li, Shuai Yan, Ke Yang, Bingbing Liu, Dongqing Wei, Lin Wang
Static pressure is an alternative method to chemical pressure for tuning the crystal structure, bonds, and physical properties of materials, and is a significant technique for the synthesis of novel materials and fundamental research. In this letter, we report the crystallization and phase transformation of p-xylene under high pressure. Our optical micrographic observations and the appearance of lattice modes in the Raman and infrared (IR) spectra indicated that p-xylene crystallizes at ∼0.1 GPa. The X-ray diffraction (XRD) pattern at 0...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28705740/proteomics-analysis-of-human-placenta-reveals-glutathione-metabolism-dysfunction-as-the-underlying-pathogenesis-for-preeclampsia
#18
Xiaohan Jin, Zhongwei Xu, Jin Cao, Ping Shao, Maobin Zhou, Zhe Qin, Yan Liu, Fang Yu, Xin Zhou, Wenjie Ji, Wei Cai, Yongqiang Ma, Chengyan Wang, Nana Shan, Ning Yang, Xu Chen, Yuming Li
Hypertensive disorder in pregnancy (HDP) refers to a series of diseases that cause the hypertension during pregnancy, including HDP, preeclampsia (PE) and eclampsia. This study screens differentially expressed proteins of placenta tissues in PE cases using 2D LC-MS/MS quantitative proteomics strategy. A total of 2281 proteins are quantified, of these, 145 altering expression proteins are successfully screened between PE and control cases (p<0.05). Bioinformatics analysis suggests that these proteins are mainly involved in many biological processes, such as oxidation reduction, mitochondrion organization, and acute inflammatory response...
July 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28705031/barium-exposure-increases-the-risk-of-congenital-heart-defects-occurrence-in-offspring
#19
Nannan Zhang, Zhen Liu, Xiaoxian Tian, Ming Chen, Ying Deng, Yixiong Guo, Nana Li, Ping Yu, Jiaxiang Yang, Jun Zhu
CONTEXT: Several studies have investigated the association between heavy metal exposure and congenital heart defects (CHDs). However, there are limited data regarding the relationship between barium exposure and the occurrence of CHDs. The objective of this study was to analyze the association between barium exposure in mothers and the risk of CHD in offspring. MATERIALS AND METHODS: We developed a case-control study with 399 cases and 490 controls with normal live births in China...
July 14, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28704546/epidemiology-of-staphylococcus-aureus-in-a-burn-unit-of-a-tertiary-care-center-in-ghana
#20
Nana Ama Amissah, Lieke van Dam, Anthony Ablordey, Opoku-Ware Ampomah, Isaac Prah, Caitlin S Tetteh, Tjip S van der Werf, Alexander W Friedrich, John W Rossen, Jan Maarten van Dijl, Ymkje Stienstra
BACKGROUND: In developing countries, hospitalized burn victims are at high risk of nosocomial infections caused by Staphylococcus aureus. Risk factors include poor infection control practices, prolonged hospitalisation and limited capacity for laboratory microbiological analyses. These problems are compounded by widespread use of antibiotics that drives the spread of multi-drug resistant bacteria. METHODS: During the study period (November 2014-June 2015), nasal and invasive S...
2017: PloS One
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