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https://www.readbyqxmd.com/read/28101871/recombinant-structural-proteins-and-their-use-in-future-materials
#1
Tara D Sutherland, Trevor D Rapson, Mickey G Huson, Jeffrey S Church
Recombinant proteins are polymers that offer the materials engineer absolute control over chain length and composition: key attributes required for design of advanced polymeric materials. Through this control, these polymers can be encoded to contain information that enables them to respond as the environment changes. However, despite their promise, protein-based materials are under-represented in materials science. In this chapter we investigate why this is and describe recent efforts to address this. We discuss constraints limiting rational design of structural proteins for advanced materials; advantages and disadvantages of different recombinant expression platforms; and, methods to fabricate proteins into solid-state materials...
2017: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/28101858/coiled-coil-design-updated-and-upgraded
#2
Derek N Woolfson
α-Helical coiled coils are ubiquitous protein-folding and protein-interaction domains in which two or more α-helical chains come together to form bundles. Through a combination of bioinformatics analysis of many thousands of natural coiled-coil sequences and structures, plus empirical protein engineering and design studies, there is now a deep understanding of the sequence-to-structure relationships for this class of protein architecture. This has led to considerable success in rational design and what might be termed in biro de novo design of simple coiled coils, which include homo- and hetero-meric parallel dimers, trimers and tetramers...
2017: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/28101267/bioart-and-bildung-wetware-art-agency-animation-an-exhibition-as-case-study
#3
Charissa N Terranova
Recent events in the field of biology have further unfixed the definition of life. The negotiability of "life" is at the center of the exhibition "Wetware: Art, Agency, Animation" at the Beall Center for Art + Technology at the University of California, Irvine. The exhibition includes art by nine international artists working in the avant-garde area of contemporary art called "bioart." This article is devoted to the unique educational space opened through the practice of bioart, focusing on how the exhibition brings the scientific question "What is life?" to a public audience...
December 2016: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28100048/unanticipated-stickiness-of-%C3%AE-pinene
#4
Hilary M Chase, Junming Ho, Mary Alice Upshur, Regan J Thomson, Victor S Batista, Franz M Geiger
Hilary M. Chase1#, Junming Ho2#, Mary Alice Upshur1, Regan J. Thomson1, Victor S. Batista3, Franz M. Geiger1* 1Department of Chemistry, Northwestern University, Evanston, IL. 60208, United States; 2 Agency for Science, Technology and Research, Institute of High Performance Computing, 1 Fusionopolis Way #16-16 Connexis North, Singapore 138632; 3Department of Chemistry, Yale University, P.O. Box 208107, New Haven, CT. 06520, United States # These authors contributed equally to this work. *corresponding author: geigerf@chem...
January 19, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28099810/anisotropic-self-assembly-of-supramolecular-polymers-and-plasmonic-nanoparticles-at-the-liquid-liquid-interface
#5
Joseph J Armao, Irina Nyrkova, Gad Fuks, Artem Osypenko, Mounir Maaloum, Emilie Moulin, Raul Arenal, Odile Gavat, Alexander N Semenov, Nicolas Giuseppone
The study of supramolecular polymers in the bulk, in solution, and at the solid-liquid interface has recently become a major topic of interest, going from fundamental aspects to applications in materials science. However, examples of 1D supramolecular polymers at the liquid-liquid interface are mostly unexplored. Here we describe the light-assisted supramolecular polymerization of triarylamine molecules and their organization at a chloroform-water interface. The resulting interfacial nematic layer of these 1D supramolecular polymers is further used as a template for the precise alignment of spherical gold nanoparticles coming from the water phase...
January 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28099673/accelerated-second-degree-bachelor-of-science-in-nursing-graduates-transition-to-professional-practice
#6
Cheryl L Brandt, Melissa R Boellaard, Kaitlyn M Wilberding
: HOW TO OBTAIN CONTACT HOURS BY READING THIS ISSUE Instructions: 1.2 contact hours will be awarded by Villanova University College of Nursing upon successful completion of this activity. A contact hour is a unit of measurement that denotes 60 minutes of an organized learning activity. This is a learner-based activity. Villanova University College of Nursing does not require submission of your answers to the quiz. A contact hour certificate will be awarded after you register, pay the registration fee, and complete the evaluation form online at http://goo...
January 1, 2017: Journal of Continuing Education in Nursing
https://www.readbyqxmd.com/read/28099416/materials-science-versatile-gel-assembly-on-a-chip
#7
Shoji Takeuchi
No abstract text is available yet for this article.
January 18, 2017: Nature
https://www.readbyqxmd.com/read/28098161/modelling-of-occupational-exposure-to-inhalable-nickel-compounds
#8
Benjamin Kendzia, Beate Pesch, Dorothea Koppisch, Rainer Van Gelder, Katrin Pitzke, Wolfgang Zschiesche, Thomas Behrens, Tobias Weiss, Jack Siemiatycki, Jerome Lavoué, Karl-Heinz Jöckel, Roger Stamm, Thomas Brüning
The aim of this study was to estimate average occupational exposure to inhalable nickel (Ni) using the German exposure database MEGA. This database contains 8052 personal measurements of Ni collected between 1990 and 2009 in adjunct with information on the measurement and workplace conditions. The median of all Ni concentrations was 9 μg/m(3) and the 95th percentile was 460 μg/m(3). We predicted geometric means (GMs) for welders and other occupations centered to 1999. Exposure to Ni in welders is strongly influenced by the welding process applied and the Ni content of the used welding materials...
January 18, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28094775/nanotechnologies-in-delivery-of-mrna-therapeutics-using-nonviral-vector-based-delivery-systems
#9
REVIEW
S Guan, J Rosenecker
Due to its safe and effective protein expression profile, in vitro transcribed messenger RNA (IVT-mRNA) represents a promising candidate in the development of novel therapeutics for genetic diseases, vaccines or gene editing strategies, especially when its inherent shortcomings (e.g. instability and immunogenicity) have been partially addressed via structural modifications. However, numerous unsolved technical difficulties in successful in vivo delivery of IVT-mRNA have greatly hindered the applications of IVT-mRNA in clinical development...
January 17, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28094427/minimalism-in-art-medical-science-and-neurosurgery
#10
Ali İhsan Ökten
The word ''minimalism'' is a word derived from French the word ''minimum''. Whereas the lexical meaning of minimum is ''the least or the smallest quantity necessary for something'', its expression in mathematics can be described as ''the lowest step a variable number can descend, least, minimal''. Minimalism, which advocates an extreme simplicity of the artistic form, is a current in modern art and music whose origins go to 1960s and which features simplicity and objectivity. Although art, science and philosophy are different disciplines, they support each other from time to time, sometimes they intertwine and sometimes they copy each other...
December 21, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28094286/creating-stable-floquet-weyl-semimetals-by-laser-driving-of-3d-dirac-materials
#11
Hannes Hübener, Michael A Sentef, Umberto De Giovannini, Alexander F Kemper, Angel Rubio
Tuning and stabilizing topological states, such as Weyl semimetals, Dirac semimetals or topological insulators, is emerging as one of the major topics in materials science. Periodic driving of many-body systems offers a platform to design Floquet states of matter with tunable electronic properties on ultrafast timescales. Here we show by first principles calculations how femtosecond laser pulses with circularly polarized light can be used to switch between Weyl semimetal, Dirac semimetal and topological insulator states in a prototypical three-dimensional (3D) Dirac material, Na3Bi...
January 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28093375/biomechanical-strength-and-failure-mechanism-of-different-tubercula-refixation-methods-within-the-framework-of-an-arthroplasty-for-shoulder-fracture
#12
Jörg Fleischer, Alexandra Schleyer, Roman Nassutt, Ulrike Grittner, Ishaq Ojodu, Sascha Jörg Hopp
BACKGROUND: Tuberosity repair in shoulder fracture prosthesis implantation still remains a challenge often leading to poor functional outcomes, despite a variety of materials and suggested suture patterns. We aimed to evaluate, which forces currently used suture and cerclage materials withstand and to assess whether they are useful with regard to stability of reconstruction of tuberosities and which failure modes they display. MATERIAL AND METHODS: Using sheep infraspinatus tendons with attached tuberosities three different suture materials (suture 1: Ethibond size 2; suture 2: Orthocord size 2; suture 3: Fiberwire size 5) and a 0...
January 13, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28092742/short-term-in-vivo-exposure-to-graphene-oxide-can-cause-damage-to-the-gut-and-testis
#13
Marta Dziewięcka, Julia Karpeta-Kaczmarek, Maria Augustyniak, Magdalena Rost-Roszkowska
Graphene oxide (GO) has unique physicochemical properties and also has a potentially widespread use in every field of daily life (industry, science, medicine). Demand for nanotechnology is growing every year, and therefore many aspects of its toxicity and biocompatibility still require further clarification. This research assesses the in vivo toxicity of pure and manganese ion-contaminated GO that were administrated to Acheta domesticus with food (at 200mgkg(-1) of food) throughout their ten-day adult life...
January 9, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28090410/retrospective-analysis-of-heavy-metal-contamination-in-rhode-island-based-on-old-and-new-herbarium-specimens
#14
Sofia M Rudin, David W Murray, Timothy J S Whitfeld
PREMISE OF THE STUDY: Herbarium specimens may provide a record of past environmental conditions, including heavy metal pollution. To explore this potential, we compared concentrations of copper, lead, and zinc in historical and new collections from four sites in Rhode Island, USA. METHODS: We compared historical specimens (1846 to 1916) to congener specimens collected in 2015 at three former industrial sites in Providence, Rhode Island, and one nonindustrial site on Block Island...
January 2017: Applications in Plant Sciences
https://www.readbyqxmd.com/read/28088098/environmental-impact-of-engineered-carbon-nanoparticles-from-releases-to-effects-on-the-aquatic-biota
#15
REVIEW
Antoine Mottier, Florence Mouchet, Éric Pinelli, Laury Gauthier, Emmanuel Flahaut
Nano-ecotoxicology is an emerging science which aims to assess the environmental effect of nanotechnologies. The development of this particular aspect of ecotoxicology was made necessary in order to evaluate the potential impact of recently produced and used materials: nanoparticles (NPs). Among all the types of NPs, carbon nanoparticles (CNPs) especially draw attention giving the increasing number of applications and integration into consumer products. However the potential impacts of CNPs in the environment remain poorly known...
January 11, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28086808/a-quiet-harvest-linkage-between-ritual-seed-selection-and-the-historical-use-of-the-finger-bladed-knife-as-a-traditional-plant-breeding-tool-in-ifugao-philippines
#16
REVIEW
Kevin M Murphy
The transverse harvest knife, also commonly called the finger or finger-bladed knife, has been utilized by rice farmers in southeast Asia for many centuries. The finger knife persisted in many traditional cultures long after the introduction of the sickle, a tool which provided farmers with the means to execute a much faster harvest. Several theories in interpretative archaeology have attempted to account for this rejection of more modern technological innovations. These theories, which include community-based social organization ideas and practical reasons for the continued use of the finger knife, are presented in this paper...
January 13, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28079492/working-with-instruments-ernst-mach-as-material-epistemologist-a-short-introduction
#17
Christoph Hoffmann, Alexandre Métraux
With the death of Ernst Mach on February 19, 1916, one day after his seventy-eighth birthday, a question finally became explicit that had been looming for some time. It was as simple as it was fundamental: who, in the end, was this man, a scientist or a philosopher? The importance of this question for contemporaries can easily be gleaned from the obituaries that appeared in the weeks following Mach's death: one in the Physikalische Zeitschrift, written by Albert Einstein, and another in the Archiv für die Geschichte der Philosophie, written by Mach's former student Heinrich Gomperz...
December 2016: Science in Context
https://www.readbyqxmd.com/read/28077925/artificial-cells-from-basic-science-to-applications
#18
Can Xu, Shuo Hu, Xiaoyuan Chen
Artificial cells have attracted much attention as substitutes for natural cells. There are many different forms of artificial cells with many different definitions. They can be integral biological cell imitators with cell-like structures and exhibit some of the key characteristics of living cells. Alternatively, they can be engineered materials that only mimic some of the properties of cells, such as surface characteristics, shapes, morphology, or a few specific functions. These artificial cells can have applications in many fields from medicine to environment, and may be useful in constructing the theory of the origin of life...
November 2016: Materials Today
https://www.readbyqxmd.com/read/28075558/immunological-principles-guiding-the-rational-design-of-particles-for-vaccine-delivery
#19
Katelyn T Gause, Adam K Wheatley, Jiwei Cui, Yan Yan, Stephen J Kent, Frank Caruso
Despite the immense public health successes of immunization over the past century, effective vaccines are still lacking for globally important pathogens such as human immunodeficiency virus, malaria, and tuberculosis. Exciting recent advances in immunology and biotechnology over the past few decades have facilitated a shift from empirical to rational vaccine design, opening possibilities for improved vaccines. Some of the most important advancements include (i) the purification of subunit antigens with high safety profiles, (ii) the identification of innate pattern recognition receptors (PRRs) and cognate agonists responsible for inducing immune responses, and (iii) developments in nano- and microparticle fabrication and characterization techniques...
January 11, 2017: ACS Nano
https://www.readbyqxmd.com/read/28075059/photochemically-driven-polymeric-network-formation-synthesis-and-applications
#20
Eva Blasco, Martin Wegener, Christopher Barner-Kowollik
Polymeric networks have been intensely investigated and a large number of applications have been found in areas ranging from biomedicine to materials science. Network fabrication via light-induced reactions is a particularly powerful tool, since light provides ready access to temporal and spatial control, opening an array of synthetic access routes for structuring the network geometry as well as functionality. Herein, the most recent light-induced modular reactions and their use in the formation of precision polymeric networks are collated...
January 11, 2017: Advanced Materials
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