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antifibrotic drug

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https://www.readbyqxmd.com/read/29785264/delay-and-inequalities-in-the-treatment-of-idiopathic-pulmonary-fibrosis-the-case-of-two-nordic-countries
#1
Ida Pesonen, Lisa Carlson, Nicola Murgia, Riitta Kaarteenaho, Carl Magnus Sköld, Marjukka Myllärniemi, Giovanni Ferrara
Background: Idiopathic pulmonary fibrosis (IPF) is characterized by progressive loss of lung function with high mortality within the first 5 years from diagnosis. In 2011-2014, two drugs, pirfenidone and nintedanib, have been approved worldwide for prevention of IPF progression. National IPF-registries have been established in both Finland and Sweden. Our study explored potential differences in the care of IPF in these two countries. Methods: Patients included consecutively in the Finnish and Swedish IPF-registries from January 1, 2014 through December 31, 2016 were included in the study...
2018: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/29738821/discovery-and-development-of-sgc-stimulators-for-the-treatment-of-pulmonary-hypertension-and-rare-diseases
#2
REVIEW
Peter Sandner, Eva-Maria Becker-Pelster, Johannes Peter Stasch
The NO/sGC/cGMP signaling cascade plays a pivotal role in regulation of cardiovascular, cardiopulmonary and cardiorenal diseases and impairment of this cascade results in severe pathologies. Therefore, pharmacological interventions, targeting this pathway are promising strategies for treating a variety of diseases. Nitrates, supplementing NO and, PDE5 inhibitors preventing cGMP degradation, are used for angina pectoris treatment and the treatment of pulmonary arterial hypertension (PAH), respectively. More recently, a new class of drugs which directly stimulate the sGC enzyme and trigger NO-independent cGMP production was introduced and termed sGC stimulators...
May 5, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29722566/inhibition-of-raf1-ameliorates-bleomycin-induced-pulmonary-fibrosis-through-attenuation-of-tgf%C3%AE-1-signaling
#3
Shuang Li, Jia Liu, Jiangning Tan, Lian Li, Mary J Kaltreider, Jing Zhao, Daniel J Kass, Dong Shang, Yutong Zhao
Idiopathic Pulmonary Fibrosis (IPF) is a fatal fibrotic lung disease associated with aberrant activation and differentiation of fibroblasts, leading to abnormal extracellular matrix (ECM) production. Currently, it is still an untreatable disease except lung transplantation. Here, we demonstrate that the Raf1 inhibitor GW5074 ameliorates lung fibrosis in bleomycin-induced pulmonary fibrosis. Post-treatment with GW5074 reduced fibronectin (FN) expression, collagen deposition, and inflammatory cell infiltration in bleomycin-challenged mice, suggesting an anti-fibrotic property of GW5074...
May 3, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29718783/an-update-on-emerging-drugs-for-the-treatment-of-idiopathic-pulmonary-fibrosis
#4
Shambhu Aryal, Steven D Nathan
Idiopathic pulmonary fibrosis is a chronic, progressive fibrotic lung disease of unknown etiology associated with a high morbidity and mortality. The hallmark of the disease is impaired healing after alveolar epithelial injury in the setting of a genetic predisposition. Development of two new drugs has changed the landscape of the treatment of IPF but more work is needed to improve outcomes and improve survival. Areas covered: The development of two antifibrotic agents, nintedanib and pirfenidone has been an exciting landmark in the treatment of IPF...
May 8, 2018: Expert Opinion on Emerging Drugs
https://www.readbyqxmd.com/read/29715556/chitosan-alginate-nano-carrier-for-transdermal-delivery-of-pirfenidone-in-idiopathic-pulmonary-fibrosis
#5
Marzieh Abnoos, Mojdeh Mohseni, Seyed Ali Javad Mousavi, Khadijeh Ashtari, Roya Ilka, Bita Mehravi
Pirfenidone (PFD) is one of the pyridine family components with anti-inflammatory, antifibrotic effects and US FDA approved for the treatment of idiopathic pulmonary fibrosis (IPF). Presently, PFD is administered orally and this has setbacks. Hence, it is important to eliminate the pharmacotherapeutic limitations of PFD. This research was carried out to study the possibility of transdermal delivery of PFD using chitosan-sodium alginate nanogel carriers. In order to synthesize chitosan-sodium alginate nanoparticles loaded with PFD, the pre-gelation method was used...
April 28, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29684284/predicting-outcomes-in-idiopathic-pulmonary-fibrosis-using-automated-ct-analysis
#6
Joseph Jacob, Brian J Bartholmai, Srinivasan Rajagopalan, Coline H M van Moorsel, Hendrik W van Es, Frouke T van Beek, Marjolijn H L Struik, Maria Kokosi, Ryoko Egashira, Anne Laure Brun, Arjun Nair, Simon L F Walsh, Gary Cross, Joseph Barnett, Angelo de Lauretis, Eoin P Judge, Sujal Desai, Ronald Karwoski, Sebastien Ourselin, Elisabetta Renzoni, Toby M Maher, Andre Altmann, Athol U Wells
AIMS: To determine whether computer-derived computed tomography measures, specifically measures of pulmonary vessel-related structures, can better predict functional decline and survival in idiopathic pulmonary fibrosis (IPF) and reduce requisite sample sizes in drug trial populations. METHODS: IPF patients undergoing volumetric non-contrast CT imaging at the Royal Brompton Hospital, London and St Antonius Hospital, Utrecht, were examined to identify pulmonary functional measures (including forced vital capacity), and visual and computer-derived (CALIPER) CT features predictive of mortality and forced vital capacity decline...
April 23, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29679639/decoding-fibrosis-mechanisms-and-translational-aspects
#7
Liliana Schaefer
Fibrosis, a complex process of abnormal tissue healing which inevitably leads to loss of physiological organ structure and function, is a world-wide leading cause of death. Despite a large body of research over the last two decades, antifibrotic approaches are mainly limited to organ replacement therapy generating high costs of medical care. In this translational issue, a unique group of basic and clinical researchers provide meaningful answers to a desperate call of society for effective antifibrotic treatments...
April 18, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29657902/inhibitory-effects-of-angiotensin-ii-receptor-blockade-on-human-tenon-fibroblast-migration-and-reactive-oxygen-species-production-in-cell-culture
#8
Duri Kim, Ushasree Pattamatta, Elizabeth Kelly, Paul R Healey, Nicole Carnt, Hans Zoellner, Andrew J R White
Purpose: We investigate the effect of angiotensin receptor blockade on the migration of human Tenon fibroblasts (HTF), using irbesartan, an angiotensin II receptor type 1 (AT1R) blocker (ARB) as a potential antifibrotic agent in glaucoma filtration surgery. Methods: Confluent HTF cultures were scratched with a 1 mL pipette tip and treated with either irbesartan (10, 50, and 100 μg/mL) or angiotensin II (2 μg/mL). The extent of HTF migration up to 30 hours, and cell number and morphology at 72 hours was evaluated...
April 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29656147/liver-fibrosis-direct-antifibrotic-agents-and-targeted-therapies
#9
REVIEW
Detlef Schuppan, Muhammad Ashfaq-Khan, Ai Ting Yang, Yong Ook Kim
Liver fibrosis and in particular cirrhosis are the major causes of morbidity and mortality of patients with chronic liver disease. Their prevention or reversal have become major endpoints in clinical trials with novel liver specific drugs. Remarkable progress has been made with therapies that efficiently address the cause of the underlying liver disease, as in chronic hepatitis B and C. Highly effective antiviral therapy can prevent progression or even induce reversal in the majority of patients, but such treatment remains elusive for the majority of liver patients with advanced alcoholic or nonalcoholic steatohepatitis, genetic or autoimmune liver diseases...
April 12, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29655797/pulmonary-administration-of-a-dry-powder-formulation-of-the-antifibrotic-drug-tilorone-reduces-silica-induced-lung-fibrosis-in-mice
#10
Ville Vartiainen, Janne Raula, Luis M Bimbo, Jenni Viinamäki, Janne T Backman, Nurcin Ugur, Esko Kauppinen, Eva Sutinen, Emmi Joensuu, Katri Koli, Marjukka Myllärniemi
The aim of this work was to study the antifibrotic effect of pulmonary administration of tilorone to lung fibrosis. L-leucine coated tilorone particles were prepared and their aerosolization properties were analyzed using two dry powder inhalers (Easyhaler and Twister). In addition, the biological activity and cell monolayer permeation was tested. The antifibrotic effect of tilorone delivered by oropharyngeal aspiration was studied in vivo using a silica-induced model of pulmonary fibrosis in mice in a preventive setting...
April 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29655377/schistosomicidal-antifibrotic-and-antioxidant-effects-of-cucurbita-pepo-l-seed-oil-and-praziquantel-combined-treatment-for-schistosoma-mansoni-infection-in-a-mouse-model
#11
E V N Beshay, A A Rady, A F Afifi, A H Mohamed
Despite the seriousness of schistosomiasis, its treatment depends only on praziquantel (PZQ), which has begun to lose its efficacy against the emergent Schistosoma mansoni-resistant strains. Therefore, the discovery of a novel schistosomicidal drug is an urgent priority. This study was designed to evaluate treatment with Cucurbita pepo L. (pumpkin) seed oil (PSO) alone and combined with PZQ against S. mansoni in experimentally infected mice. The study involved five groups: GI was the normal control; GII was the infected control; GIII was treated with an oral dose of PZQ of 500 mg/kg/day for two successive days, starting in the sixth week post infection; GIV was treated with an oral dose of PSO of 50 mg/kg/day for four weeks, starting in the fourth week post infection; and GV was treated with combined PSO-PZQ...
April 15, 2018: Journal of Helminthology
https://www.readbyqxmd.com/read/29651817/two-cases-of-chloromethylisothiazolinone-and-methylisothiazolinone-associated-toxic-lung-injury
#12
Eun Lee, Seung Kook Son, Jisun Yoon, Hyun Ju Cho, Song I Yang, Sungsu Jung, Kyung Hyun Do, Young Ah Cho, So Yeon Lee, Dong Uk Park, Soo Jong Hong
Previous animal studies have not conclusively determined the association between exposure to humidifier disinfectants (HDs) containing 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and/or 2-methyl-4-isothiazolin-3-one (MIT) and development of HD-associated lung injuries. Nonetheless, patients exposed to HDs containing only CMIT and/or MIT showed clinically similar lung injuries to those exposed to HDs containing polyhexamethylene guanidine (PHMG) or oligo (2-[2-ethoxy]ethoxyethyl) guanidinium chloride (PGH)...
April 16, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29643251/pharmacological-characterization-of-iw-1973-a-novel-soluble-guanylate-cyclase-stimulator-with-extensive-tissue-distribution-anti-hypertensive-anti-inflammatory-and-anti-fibrotic-effects-in-preclinical-models-of-disease
#13
Jenny V Tobin, Daniel P Zimmer, Courtney Shea, Peter Germano, Sylvie G Bernier, Guang Liu, Kim Long, Joy Miyashiro, Sheila Ranganath, Sarah Jacobson, Kim Tang, G-Yoon Jamie Im, James Sheppeck, Joel D Moore, Kristine Sykes, James Wakefield, Renee Sarno, Ali R Banijamali, Albert T Profy, G Todd Milne, Mark G Currie, Jaime L Masferrer
Soluble guanylate cyclase (sGC), a key signal-transduction enzyme, increases the conversion of guanosine-5'-triphosphate (GTP) to cyclic guanosine-3',5'-monophosphate (cGMP) upon binding of nitric oxide (NO). Endothelial dysfunction and/or reduced NO signaling have been implicated in cardiovascular disease pathogenesis and complications of diabetes, and have been associated with other disease states and aging. sGC stimulators are small-molecule drugs that bind sGC and enhance NO-mediated cGMP signaling. The pharmacological characterization of IW-1973, a novel clinical-stage sGC stimulator, is described...
April 11, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29621624/astilbin-ameliorates-pulmonary-fibrosis-via-blockade-of-hedgehog-signaling-pathway
#14
Jie Zhang, Hanchen Liu, Chenguang Song, Jinjin Zhang, Youlei Wang, Changjun Lv, Xiaodong Song
BACKGROUND AND OBJECTIVE: The nature of pulmonary fibrosis involves inadequate repair of the epithelial cell barrier accompanied by impaired regulation of the fibroblast. Moreover, pulmonary fibrosis currently lacks an effective therapeutic drug. This study targets the protection of the epithelial cell and fibroblast to identify a novel, potentially therapeutic drug (i.e., astilbin). METHODS: In this study, the cytotoxicity of astilbin was firstly detected using CCK-8...
April 2, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29621129/plants-and-surgery-the-protective-effects-of-thymoquinone-on-hepatic-injury-a-systematic-review-of-in-vivo-studies
#15
REVIEW
Aysun Tekbas, Jutta Huebner, Utz Settmacher, Uta Dahmen
Multimodal treatment concepts including liver transplantation for hepatocellular carcinoma (HCC), extended resection methods and neoadjuvant chemotherapy for colorectal liver metastasis significantly improve patients’ outcome. However, surgery-induced hepatic ischemia-reperfusion injury (IRI) and chemotherapy-associated hepatotoxicity result in hepatocellular damage and compromised liver function. Activation of common key pathways in ischemic liver and hepatotoxic injury results in oxidative stress, inflammatory responses and apoptosis causing organ damage...
April 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29589070/vitamin-a-coupled-liposomes-carrying-tlr4-silencing-shrna-induce-apoptosis-of-pancreatic-stellate-cells-and-resolution-of-pancreatic-fibrosis
#16
Yuwei Zhang, Dan Yue, Liuliu Cheng, Anliang Huang, Nanwei Tong, Ping Cheng
Chronic pancreatitis leads to irreversible damage in pancreatic endocrine and exocrine functions. However, there is no clinically available antifibrotic drug. Pancreatic stellate cells (PSCs) can be activated by Toll-like receptor 4 (TLR4) responses to its ligands and they contribute to the formation of pancreatic fibrosis. Silencing the expression of TLR4 in PSCs by RNAi may be a novel therapeutic strategy for the treatment of pancreatic fibrosis. In addition, PSCs have a remarkable capacity for vitamin A uptake most likely through cellular retinol binding protein (CRBP)...
March 27, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29577199/experimental-analysis-of-the-efficacy-of-dihydroquercetin-on-the-model-of-chronic-nonbacterial-inflammation-of-the-prostatic-gland
#17
T G Borovskaya, S I Kamalova, M E Polyektova, V A Mashanova, A V Vychuzhanina, S I Kseneva, M B Plotnikov, V E Goldberg
We studied the efficiency of dihydroquercetin on the model of chronic nonbacterial inflammation of the prostatic gland in rats. It was found that administration of dihydroquercetin was followed by a significant decrease in the area of the connective tissue in the prostatic gland to initial levels, which attested to antifibrotic properties of this oxidant. Additionally, the substance prevented the development of atrophy of acinus epithelium. After administration of reference drug Prostamol Uno, only moderate antifibrotic effects were observed...
March 26, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29574980/blockade-of-the-renin-angiotensin-aldosterone-system-in-patients-with-arrhythmogenic-right-ventricular-dysplasia-a-double-blind-multicenter-prospective-randomized-genotype-driven-study-brave-study
#18
Elodie Morel, Ab Waheed Manati, Patrice Nony, Delphine Maucort-Boulch, Francis Bessière, Xu Cai, Timothee Besseyre des Horts, Alexandre Janin, Adrien Moreau, Phillippe Chevalier
Arrhythmogenic right ventricular dysplasia (ARVD) is a rare cardiomyopathy characterized by the progressive replacement of cardiomyocytes by fatty and fibrous tissue in the right ventricle (RV). These infiltrations lead to cardiac electrical instability and ventricular arrhythmia. Current treatment for ARVD is empirical and essentially based on treatment of arrhythmia. Thus, there is no validated treatment that will prevent the deterioration of RV function in patients with ARVD. The aim of the BRAVE study is to evaluate the effect of ramipril, an angiotensin-converting enzyme inhibitor, on ventricular myocardial remodeling and arrhythmia burden in patients with ARVD...
March 25, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29572618/the-use-of-statins-in-patients-with-chronic-liver-disease-and-cirrhosis
#19
REVIEW
Carlos Moctezuma-Velázquez, Juan G Abraldes, Aldo J Montano-Loza
PURPOSE OF REVIEW: Statins are drugs developed to treat hypercholesterolemia. Its use in patients with liver disease has been limited because one of its potential and most feared side effects is hepatotoxicity. However, there is robust evidence that supports the safety of statins in this population in the absence of severe liver dysfunction. In this review, we will summarize the efficacy and safety of statins in cirrhosis. RECENT FINDINGS: Statins are effective in the treatment of dyslipidemia in patients with liver disease, because of their pleiotropic properties...
June 2018: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29550081/pentoxifylline-tocopherol-and-clodronate-for-the-treatment-of-mandibular-osteoradionecrosis-a-systematic-review
#20
REVIEW
Miriam Martos-Fernández, Manel Saez-Barba, Jose López-López, Albert Estrugo-Devesa, Jose María Balibrea-Del-Castillo, Coro Bescós-Atín
OBJECTIVE: The purpose of this study was to evaluate the healing benefit provided by the antioxidant and antifibrotic properties of pentoxifylline-tocopherol or pentoxifylline-tocopherol-clodronate in combination therapy for osteoradionecrosis. STUDY DESIGN: We searched for relevant reports in PubMed by using a combination of "osteoradionecrosis" and the following keywords: "pentoxifillyne," "tocopherol," "vitamin E," or "clodronate...
February 14, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
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