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intracranial haemorrhage

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https://www.readbyqxmd.com/read/29471250/duret-haemorrhage-an-unusual-finding-in-compression-of-neck-structures
#1
Tanuj Kanchan, Alok Atreya
Hanging is one of the most lethal methods of suicide, where survival is an obvious rarity. Those who survive the initial act of hanging mostly suffer from hypoxic ischemic encephalopathy, and show some form of neurological damage. Intracranial haemorrhages are rarely associated with hanging. We report the first case of Duret haemorrhages in a 58 years old victim who survived for 8 days after the attempted hanging. Duret haemorrhage is mostly associated with fatal outcome. It is thus implied that cerebral edema should be brought under control at the earliest to prevent transtentorial herniation and subsequent Duret haemorrhages...
February 15, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29459608/distribution-pattern-and-outcome-of-the-patients-in-the-intensive-care-unit-of-bangabandhu-sheikh-mujib-medical-university-a-short-term-analysis
#2
S I Alam, M A Hossain, M Aftabuddin, M A Hye, M K Mondal
The aim of the study was to describe the characteristics of patients admitted to intensive care unit and their outcome in Bangabandhu Sheikh Mujib Medical University, Bangladesh. This retrospective, descriptive study was conducted in the intensive care unit of Bangabandhu Sheikh Mujib Medical University (BSMMU) from January 2016 to June 2016. Data was retrieved from hospital records of all admitted patients regarding age, gender, admission source, reason for admission, length of ICU stay, requirement of mechanical ventilation, number of organ failure and their outcome...
January 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29459367/endovascular-thrombectomy-beyond-12-hours-of-stroke-onset-a-stroke-network-s-experience-of-late-intervention
#3
Ronan Motyer, John Thornton, Sarah Power, Paul Brennan, Alan O'Hare, Seamus Looby, David J Williams, Barry Moynihan, Sean Murphy
BACKGROUND: Selected patients with proximal anterior circulation ischemic stroke who demonstrate limited infarct and sufficient penumbra may benefit from endovascular thrombectomy (EVT) beyond conventional time limits. OBJECTIVE: To perform a retrospective review of all cases of EVT performed at our institution for proximal anterior circulation acute ischemic stroke with onset >12 hours. MATERIALS AND METHODS: Patients were assessed with non-contrast CT brain and multiphase CT angiography, with Alberta Stroke Program Early CT Score (ASPECTS) and collateral grade informing patient selection...
February 19, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29457918/quality-of-life-among-patients-during-subacute-phase-following-stroke-during-hospitalisation-period-in-shanghai
#4
Jiang Jingwen, Jin Han, Zhang Yu, Huang Xiaojun, Zhuang Junpeng, Shen Fanxia, Liu Jianrong
OBJECTIVE: This study aimed to investigate the factors influencing the quality of life of in-hospital subacute stroke patients. METHODS: The patients of subacute stroke (within four weeks) in our institution between 2015 and 2016 were recruited. Patients' characteristics and QOL were obtained from medical charts and stroke-specific quality of life scale (SS-QOL). Associations of each domain in SS-QOL with socio-demographic, clinical factors and patient satisfaction were investigated using the linear regression models...
February 19, 2018: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29441772/-current-status-of-forensic-identification-for-blunt-injuries-of-internal-carotid-arterial-system
#5
REVIEW
X M Wu, G Zhang, Q Wang, Z X Ni, M Liu, L B Yun, X F Yi
Internal carotid arterial system is the main source of blood supply in brain. In forensic identification practice, blunt injures of internal carotid arterial system usually cause complications such as thrombus, aneurysm and arteriovenous fistula, etc. The deaths following delayed cerebral infarction or intracranial haemorrhage are not rare. At present, literature of deaths caused by blunt injuries of internal carotid arterial system mainly consist of case reports in China. This paper reviews related literature and case reports at home and abroad, and summarizes forensic medical features and identification method of the deaths caused by such injuries...
December 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29440454/is-traumatic-intracranial-haemorrhage-a-specific-risk-factor-for-atrial-fibrillation
#6
Yoann Launey, Philippe Seguin
No abstract text is available yet for this article.
March 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29383860/risk-of-stroke-and-bleeding-in-patients-with-heart-failure-and-chronic-kidney-disease-a-nationwide-cohort-study
#7
Line Melgaard, Thure Filskov Overvad, Flemming Skjøth, Jeppe Hagstrup Christensen, Torben Bjerregaard Larsen, Gregory Y H Lip
AIMS: The aim of this study was to assess the prognostic value of chronic kidney disease (CKD) in relation to ischaemic stroke, intracranial haemorrhage, major bleeding, and all-cause death in heart failure patients without atrial fibrillation. METHODS AND RESULTS: In this observational cohort study, heart failure patients without atrial fibrillation were identified using Danish nationwide registries. Risk of stroke, major haemorrhage, and death were calculated after 1 and 5 years to compare patients with and without CKD, ±dialysis [dialysis: CKD with renal replacement therapy (CKD-RRT); no dialysis: CKD-no RRT]...
January 31, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29383476/apoplexy-in-nonfunctioning-pituitary-adenomas
#8
REVIEW
Luiz Eduardo Wildemberg, Andrea Glezer, Marcello D Bronstein, Mônica R Gadelha
Pituitary apoplexy is an uncommon event, occurring due to the infarction and/or haemorrhage usually of a previously unknown pituitary adenoma. It can occur in all adenoma subtypes but is more common in nonfunctioning pituitary adenomas. The physiopathology is not completely clear, and precipitating factors, such as major surgeries, anticoagulant use or pituitary dynamic tests, can be found in up to 40% of patients. The clinical presentation is characterized by a rapid onset with a headache as the main symptom, but visual disturbances can also be present as well as meningism and intracranial hypertension...
January 31, 2018: Pituitary
https://www.readbyqxmd.com/read/29371325/a-three-year-prospective-study-of-the-presentation-and-clinical-outcomes-of-major-bleeding-episodes-associated-with-oral-anticoagulant-use-in-the-uk-orange-study
#9
Laura Green, Joachim Tan, Joan K Morris, Raza Alikhan, Nicola Curry, Tamara Everington, Rhona Mclean, Khalid Saja, Simon Stanworth, Campbell Tait, Peter MacCallum
The outcomes of patients developing major bleeding on oral anticoagulants remain largely unquantified. Objectives are to: 1) describe the burden of major haemorrhage associated with all available oral anticoagulants in terms of: proportion of bleeds which are intracranial-haemorrhages, in-hospital mortality and duration of hospitalisation following major bleeding; 2) identify risk factors for mortality; 3) compare characteristics of major haemorrhage between warfarin and direct-oral anticoagulants for the subgroup of atrial fibrillation and venous-thromboembolism patients...
January 25, 2018: Haematologica
https://www.readbyqxmd.com/read/29364007/complication-rates-of-external-ventricular-drain-insertion-by-surgeons-of-different-experience
#10
J Yuen, W Selbi, S Muquit, T Berei
Introduction Insertion of external ventricular drain (EVD) is a widely accepted, routinely performed procedure for treatment of hydrocephalus and raised intracranial pressure. The purpose of this study was to investigate whether a surgeon's experience affects the associated complication rate. Methods This retrospective study included all adult patients undergoing EVD insertion at a single centre between July 2013 and June 2015. Medical records were retrieved to obtain details on patient demographics, surgical indication, risk factors for infection and use of anticoagulants or antiplatelets...
January 24, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29363895/overview-of-evidence-on-emergency-carotid-stenting-in-patients-with-acute-ischemic-stroke-due-to-tandem-occlusions-a-systematic-review-and-meta-analysis
#11
Andreia Coelho, Miguel Lobo, Ricardo Gouveia, Diogo Silveira, Jacinta Campos, Rita Augusto, Nuno Coelho, Alexandra Canedo
INTRODUCTION: Endovascular intracranial thrombectomy (IT) has established itself as the standard of care in treating large-vessel anterior circulation acute ischemic stroke (AIS). However, internal carotid artery (ICA) stenosis/occlusion hampers distal access and controversy about simultaneous emergency ICA stenting ensues. The purpose of this review was to evaluate the safety of emergency ICA stenting in combination with IT for AIS with tandem occlusions. To our knowledge this is the first meta-analysis to evaluate emergency ICA stenting in tandem occlusions, combining results from studies with a control group...
January 23, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29359331/presentation-course-and-outcome-of-postneonatal-presentations-of-vein-of-galen-malformation-a-large-single-institution-case-series
#12
Vignesh Gopalan, Adam Rennie, Fergus Robertson, Lakshmi Kanagarajah, Claire Toolis, Sanjay Bhate, Vijeya Ganesan
AIM: To describe presentation, clinical course, and outcome in postneonatal presentations of vein of Galen malformation (VGM). METHOD: Children older than 28 days presenting with VGM (from 2006-2016) were included. Notes/scans were reviewed. Outcome was dichotomized into 'good' or 'poor' using the Recovery and Recurrence Questionnaire. Logistic regression was performed to explore relationships between clinico-radiological features and outcome. RESULTS: Thirty-one children (18 males, 13 females) were included, presenting at a median age of 9...
January 23, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29356789/tolerance-and-outcomes-of-stereotactic-radiosurgery-combined-with-anti-programmed-cell-death-1-pembrolizumab-for-melanoma-brain-metastases
#13
Charlee Nardin, Christine Mateus, Mathieu Texier, Emilie Lanoy, Salima Hibat-Allah, Samy Ammari, Caroline Robert, Frederic Dhermain
Anti-programmed cell death-1 (anti-PD1) antibodies are currently the first-line treatment for patients with metastatic BRAF wild-type melanoma, alone or combined with the anti-CTLA4 monoclonal antibody, ipilimumab. To date, data on safety and the outcomes of patients treated with the anti-PD1 monoclonal antibodies, pembrolizumab (PB), or nivolumab, combined with stereotactic radiosurgery (SRS), for melanoma brain metastases (MBM) are scarce. We retrospectively reviewed all patients with MBM treated with PB combined with SRS between 2012 and 2015...
January 19, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29350803/thrombectomy-outcomes-for-acute-stroke-patients-with-anterior-circulation-tandem-lesions-a-clinical-registry-and-an-update-of-systematic-review-with-meta-analysis
#14
Udi Sadeh-Gonik, Noam Tau, Tal Friehmann, Serge Bracard, René Anxionnat, Anne-Laure Derelle, Romain Tonnelet, Liang Liao, Sébastien Richard, Xavier Armoiry, Benjamin Gory
BACKGROUND AND PURPOSE: Although mechanical thrombectomy (MT) appears to be superior in stroke patients with extracranial carotid disease (ECD) compared to thrombolysis alone, the impact of emergent carotid stenting during MT remains unclear. We assessed the MT outcomes in anterior stroke patients with ECD, especially when combined with carotid stenting. METHODS: We performed a retrospective analysis of our registry and conducted an update of a systematic review and meta-analysis of MT studies with or without stenting for anterior circulation stroke with ECD published between November 2010 and April 2017...
January 19, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29348138/development-and-validation-of-outcome-prediction-models-for-aneurysmal-subarachnoid-haemorrhage-the-sahit-multinational-cohort-study
#15
Blessing N R Jaja, Gustavo Saposnik, Hester F Lingsma, Erin Macdonald, Kevin E Thorpe, Muhammed Mamdani, Ewout W Steyerberg, Andrew Molyneux, Airton Leonardo de Oliveira Manoel, Bawarjan Schatlo, Daniel Hanggi, David Hasan, George K C Wong, Nima Etminan, Hitoshi Fukuda, James Torner, Karl L Schaller, Jose I Suarez, Martin N Stienen, Mervyn D I Vergouwen, Gabriel J E Rinkel, Julian Spears, Michael D Cusimano, Michael Todd, Peter Le Roux, Peter Kirkpatrick, John Pickard, Walter M van den Bergh, Gordon Murray, S Claiborne Johnston, Sen Yamagata, Stephan Mayer, Tom A Schweizer, R Loch Macdonald
OBJECTIVE: To develop and validate a set of practical prediction tools that reliably estimate the outcome of subarachnoid haemorrhage from ruptured intracranial aneurysms (SAH). DESIGN: Cohort study with logistic regression analysis to combine predictors and treatment modality. SETTING: Subarachnoid Haemorrhage International Trialists' (SAHIT) data repository, including randomised clinical trials, prospective observational studies, and hospital registries...
January 18, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29345587/is-there-a-role-for-oral-triple-therapy-in-patients-with-acute-coronary-syndromes-without-atrial-fibrillation
#16
Nikolaos Spinthakis, Mohamed Farag, Zaki Akhtar, Diana Adrienne Gorog
BACKGROUND: Acute coronary syndrome (ACS) patients, despite treatment with dual antiplatelet therapy (DAPT), have up to 10% risk of recurrent major adverse cardiac events (MACE) in the short term. METHODS: Here we review studies using more potent antithrombotic agent combinations to reduce this risk, namely triple therapy (TT) with the addition of an oral anticoagulant, PAR-1 antagonist, or cilostazol to DAPT (mainly aspirin and clopidogrel), and discuss the limitations of trials to date...
January 16, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29338437/elderly-population-have-a-decreased-aneurysmal-subarachnoid-hemorrhage-incidence-rate-than-middle-aged-population-a-descriptive-analysis-of-8-144-cases-in-mainland-china
#17
Yì Xiáng J Wáng, Lihong Zhang, Lin Zhao, Jian He, Xian-Jun Zeng, Heng Liu, Yun-Jun Yang, Shang-Wei Ding, Zhong-Fei Xu, Yong-Ming He, Lin Yang, Lan Sun, Ke-Jie Mu, Bai-Song Wang, Xiao-Hong Xu, Zhong-You Ji, Jian-Hua Liu, Jin-Zhou Fang, Rui Hou, Feng Fan, Guang-Ming Peng, Yue-Qi Zhu, Sheng-Hong Ju, Wai S Poon
PURPOSE: Rupture of an intracranial aneurysm is a life-threatening acute cerebrovascular event. The purpose of this study was to investigate whether aneurysmal subarachnoid haemorrhage (SAH) incidence rate is higher or lower in elderly population than in middle aged population. MATERIALS AND METHODS: Aneurysmal SAH cases were collected retrospectively from the archives of 21 hospitals in Mainland China. All the cases were collected from September 2016 and backward consecutively for a period of time up to 8 years...
January 17, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29334797/association-of-functional-mmp-2-gene-variant-with-intracranial-aneurysms-case-control-genetic-association-study-and-meta-analysis
#18
Varinder S Alg, Xiayi Ke, Joan Grieve, Stephen Bonner, Daniel C Walsh, Diederik Bulters, Neil Kitchen, Henry Houlden, David J Werring
INTRODUCTION: Abnormalities in Matrix Metalloproteinase (MMP) genes, which are important in extracellular matrix (ECM) maintenance and therefore arterial wall integrity are a plausible underlying mechanism of intracranial aneurysm (IA) formation, growth and subsequent rupture. We investigated whether the rs243865 C > T SNP (single nucleotide polymorphism) within the MMP-2 gene (which influences gene transcription) is associated with IA compared to matched controls. MATERIALS AND METHODS: We conducted a case-control genetic association study, adjusted for known IA risk factors (smoking and hypertension), in a UK Caucasian population of 1409 patients with intracranial aneurysms (IA), and 1290 matched controls, to determine the association of the rs243865 C > T functional MMP-2 gene SNP with IA (overall, and classified as ruptured and unruptured)...
January 15, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29326127/skill-sets-required-for-the-management-of-military-head-face-and-neck-trauma-a-multidisciplinary-consensus-statement
#19
John Breeze, R Blanch, J Baden, A M Monaghan, D Evriviades, S E Harrisson, S Roberts, A Gibson, N MacKenzie, D Baxter, A J Gibbons, S Heppell, J G Combes, R F Rickard
INTRODUCTION: The evolution of medical practice is resulting in increasing subspecialisation, with head, face and neck (HFN) trauma in a civilian environment usually managed by a combination of surgical specialties working as a team. However, the full combination of HFN specialties commonly available in the NHS may not be available in future UK military-led operations, necessitating the identification of a group of skill sets that could be delivered by one or more deployed surgeons. METHOD: A systematic review was undertaken to identify those surgical procedures performed to treat acute military head, face, neck and eye trauma...
January 10, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29306488/reintroduction-of-anticoagulant-therapy-after-intracranial-haemorrhage-if-and-when
#20
REVIEW
Martin Scott, Ryan Low, Dawn Swan, Jecko Thachil
Intracranial haemorrhage is a devastating complication of anticoagulation. In surviving patients, physicians will be faced with the dilemma of if and when treatment should be reintroduced. There is little evidence to support this decision making and guidelines refrain from making specific recommendations. Existing data relates almost exclusively to vitamin K antagonists and is entirely retrospective. There appears to be an overall benefit to reintroducing anticoagulation in most patients; although, this may not be advocated in those at the highest risk of recurrent bleeding...
December 20, 2017: Blood Reviews
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