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https://www.readbyqxmd.com/read/29665347/comparison-of-revised-trauma-score-based-on-intracranial-haemorrhage-volume-among-head-injury-patients
#1
Albert Tito, Sonny G R Saragih, Diana Natalia
Head injury is one of the leading causes of mortality and morbidity at all ages and may develop into intracranial haemorrhage and increasing intracranial pressure. Pre-assessment must be conducted to head injury patients to decide the treatment plan. The aim of this study was to compare Revised Trauma Score (RTS) based on intracranial haemorrhage volume among head injury patients. This study was an analytic study with cross-sectional design where 31 patients were studied. The admission RTS and patients' status data were obtained from medical records at Dr...
2018: Prague Medical Report
https://www.readbyqxmd.com/read/29665012/wavelet-pressure-reactivity-index-a-validation-study
#2
Xiuyun Liu, Marek Czosnyka, Joseph Donnelly, Danilo Cardim, Manuel Cabeleira, Peter J Hutchinson, Xiao Hu, Peter Smielewski, Ken Brady
KEY POINTS: The brain is vulnerable to damage from too little or too much blood flow. A physiological mechanism called cerebral autoregulation (CA) exists to maintain stable blood flow even if cerebral perfusion pressure (CPP) is changing. A robust method for assessing CA is not yet available. There are still some problems with the traditional measure, the pressure reactivity index (PRx). We introduced a new method, wavelet transform method (wPRx) to assess CA using data from two sets of controlled hypotension experiments in piglets: One set with artificially manipulated ABP oscillations; the other group were spontaneous ABP waves...
April 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29664991/haemostatic-therapies-for-acute-spontaneous-intracerebral-haemorrhage
#3
REVIEW
Rustam Al-Shahi Salman, Zhe Kang Law, Philip M Bath, Thorsten Steiner, Nikola Sprigg
BACKGROUND: Outcome after spontaneous (non-traumatic) intracerebral haemorrhage (ICH) is influenced by haematoma volume; up to one-third of ICHs enlarge within 24 hours of onset. Early haemostatic therapy might improve outcome by limiting haematoma growth. This is an update of a Cochrane Review first published in 2006, and last updated in 2009. OBJECTIVES: To examine 1) the effectiveness and safety of individual classes of haemostatic therapies, compared against placebo or open control, in adults with acute spontaneous intracerebral haemorrhage, and 2) the effects of each class of haemostatic therapy according to the type of antithrombotic drug taken immediately before ICH onset (i...
April 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29660970/inflammation-and-rehabilitation-outcomes-in-patients-with-nontraumatic-intracranial-haemorrhage
#4
Mirella Boselli, Roberto Aquilani, Roberto Maestri, Maria Pia Achilli, Nadia Arrigoni, Evasio Pasini, Anna Maria Condino, Federica Boschi, Maurizia Dossena, Daniela Buonocore, Manuela Verri
BACKGROUND: Systemic inflammation and its impact on rehabilitation for patients with non-traumatic haemorrhagic injury (HBI) sequelae has not yet been adequately documented. OBJECTIVE AND METHODS: We therefore considered 31 patients with HBI, to determine the serum levels of inflammatory markers (C-Reactive Protein, CRP and or interleukine-6, IL-6) to establish their impact on functional status (Functional Independence Measure, FIM: 18 indicating the worst performance and 126, a normal score)...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29611866/gamma-knife-radiosurgery-for-arteriovenous-malformations-general-principles-and-preliminary-results-in-a-swiss-cohort
#5
Matthieu Raboud, Constantin Tuleasca, Philippe Maeder, Luis Schiappacasse, Maud Marguet, Roy Thomas Daniel, Marc Levivier
INTRODUCTION: Arteriovenous malformations (AVMs) are a type of vascular malformation characterised by an abnormal connection between arteries and veins, bypassing the capillary system. This absence of capillaries generates an elevated pressure (hyperdebit), in both the AVM and the venous drainage, increasing the risk of rupture. Management modalities are: observation, microsurgical clipping, endovascular treatment and radiosurgery. The former can be used alone or in the frame of a multidisciplinary approach...
April 3, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29600004/efficacy-and-safety-of-intravenous-recombinant-tissue-plasminogen-activator-in-mild-ischaemic-stroke-a-meta-analysis
#6
REVIEW
Shoujiang You, Anubhav Saxena, Xia Wang, WeeYong Tan, Qiao Han, Yongjun Cao, Chun-Feng Liu
The benefits and safety of intravenous recombinant tissue plasminogen activator (IV-tPA) for patients with mild ischaemic stroke (MIS) are still unclear. The objective of this meta-analysis was to evaluate the efficacy and safety of IV-tPA as treatment for patients with MIS. We performed a systematic literature search across MEDLINE, Embase, Central, Global Health and Cumulative Index to Nursing and Allied Health Literature (CINAHL), from inception to 10 November 2016, to identify all related studies. Where possible, data were pooled for meta-analysis with odds ratio (OR) and corresponding 95% confidence interval (CI) using the fixed-effects model...
March 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/29577257/pharmacogenetics-of-vitamin-k-antagonists-and-bleeding-risk-prediction-in-atrial-fibrillation
#7
María José Serna, José Miguel Rivera-Caravaca, Rocío Gonzalez-Conejero, María Asunción Esteve-Pastor, Mariano Valdés, Vicente Vicente, Gregory Y H Lip, Vanessa Roldán, Francisco Marín
BACKGROUND: Polymorphisms in the vitamin K epoxide reductase complex 1 (VKORC1) and cytochrome P450 2C9 (CYP2C9) genes increase the bleeding risk in anticoagulated atrial fibrillation (AF) patients. Here, we aimed to investigate whether VKORC1 and CYP2C9 polymorphisms improved the predictive performance for major bleeding using the HAS-BLED score. MATERIAL AND METHODS: We recruited 652 consecutive AF patients stable on vitamin K antagonist (INR 2.0-3.0) during at least the previous 6 months...
March 25, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29574426/delayed-neurological-deficits-after-endovascular-placement-of-a-pipeline-embolisation-device-clinical-manifestation-and-treatment
#8
Naveen Sablani, Maryam Mumtaz Hasan, Ashik Shrestha, Jeffrey Farkas
Endovascular treatment has been the mainstay of therapy for repair of both ruptured and unruptured cerebral aneurysms. Flow diverter devices offer a new option for the treatment of complex aneurysms that were previously not amenable to coiling. Procedural adverse effects include intracranial haemorrhage and ischaemic stroke, which usually occur on the same day. Delayed complications are rare. We report a case of a patient who underwent placement of a pipeline embolisation device and developed delayed neurological deficits, which were thought to be an inflammatory reaction to the hydrophilic coating used in guidewires and microcatheters...
March 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29571862/emergent-carotid-artery-stenting-in-atherosclerotic-disease-of-the-internal-carotid-artery-with-tandem-intracranial-occlusion
#9
Marta Rodrigues, André Cunha, Sofia Figueiredo, Andreia Carvalho, Miguel Veloso, Pedro Barros, Tiago Gregório, Ludovina Paredes, João Pinho, Sérgio Castro, Manuel Ribeiro
BACKGROUND: Several randomized clinical trials have proven the safety and efficacy of mechanical thrombectomy (MT) in large vessel occlusions; nonetheless, there is still no consensus concerning hyperacute management of tandem occlusions. Recent studies have suggested that emergent carotid artery stenting (eCAS), along with mechanical thrombectomy, is an effective and safe treatment option. AIMS: To characterize the safety and short-term outcome of patients treated with eCAS during endovascular treatment of acute ischaemic stroke...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29564837/prothrombin-complex-concentrate-for-major-bleeding-on-factor-xa-inhibitors-a-prospective-cohort-study
#10
Sam Schulman, Peter L Gross, Bruce Ritchie, Susan Nahirniak, Yulia Lin, Lani Lieberman, Marc Carrier, Mark A Crowther, Indy Ghosh, Alejandro Lazo-Langner, Michelle Zondag
Oral factor Xa inhibitors are increasingly used for anticoagulation, but there is no approved reversal agent. Prothrombin complex concentrate (PCC) for the management of Xa-inhibitor-associated bleeding has been described in small case series and one cohort study. Patients on apixaban or rivaroxaban, suffering a major bleed, were treated at nine Canadian hospitals as per existing hospital protocol with a fixed dose of PCC 2,000 units and subsequently recruited for a 30-day follow-up. The treating physician evaluated the haemostatic effectiveness as observed during the first day as good, moderate or poor/none, using an assessment guide...
March 21, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29556685/mortality-among-patients-due-to-adverse-drug-reactions-that-lead-to-hospitalization-a-meta-analysis
#11
Tejas K Patel, Parvati B Patel
PURPOSE: The aim of this study was to estimate the prevalence of mortality among patients due to adverse drug reactions that lead to hospitalisation (fatal ADRAd ), to explore the heterogeneity in its estimation through subgroup analysis of study characteristics, and to identify system-organ classes involved and causative drugs for fatal ADRAd . METHODS: We identified prospective ADRAd -related studies via screening of the PubMed and Google Scholar databases with appropriate key terms...
March 19, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29549137/intracranial-haemangiopericytoma-a-rare-case-presenting-with-haemorrhage
#12
Mohamed Abdelsadg, Avinash Kumar Kanodia, Colin Smith, Eric Ballantyne, Khaled Patran
No abstract text is available yet for this article.
March 16, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29544998/evaluation-of-safety-efficacy-and-clinical-outcome-after-endovascular-treatment-of-aneurysmal-subarachnoid-haemorrhage-in-coil-first-setting-a-10-year-series-from-a-single-centre
#13
Muhammad AlMatter, Pervinder Bhogal, Marta Aguilar Pérez, Victoria Hellstern, Hansjörg Bäzner, Oliver Ganslandt, Hans Henkes
INTRODUCTION: The endovascular treatment (EVT) of ruptured cerebral aneurysms has been widely adopted after publication of the ISAT. In this study we sought to evaluate the safety and efficacy of the EVT for ruptured aneurysms based on 10-year series from a single centre with coil-first strategy. METHODS: All patients with aneurysmal subarachnoid haemorrhage (aSAH) treated between 2007 and 2016 were retrospectively reviewed and divided according to initial treatment into an EVT and a microsurgical clipping (MSC) group...
March 12, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29538640/anticoagulation-resumption-after-intracranial-haemorrhage-with-mechanical-valves-a-data-free-zone
#14
Freek W A Verheugt
No abstract text is available yet for this article.
March 12, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29536741/the-relationship-between-intracranial-pressure-and-lactate-pyruvate-ratio-in-patients-with-subarachnoid-haemorrhage
#15
T Cesak, J Adamkov, J Habalova, P Poczos, M Kanta, M Bartos, T Hosszu
AIM: The aim of this study was to analyse the relationship between intracranial pressure (intracranial pressure monitoring) and lactate pyruvate ratio (cerebral microdialysis) in patients with ruptured intracranial aneurysms. METHODS: In a group of fifteen patients, intracranial pressure and lactate/pyruvate ratios were measured and logged in hourly intervals. The relationship between these two variables was subsequently analysed in two ways. 1) Intracranial hypertension (ICP > 20 mmHg) in the presence of energy deprivation (L/P ratio > 30) was noted...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29532238/is-the-brain-spared-in-crimean-congo-haemorrhagic-fever-an-mr-swi-study-to-reveal-cns-involvement
#16
Bilge Öztoprak, İbrahim Öztoprak, Aynur Engin
OBJECTIVES: The aim of this prospective study is to investigate the central nervous system involvement in Crimean-Congo haemorrhagic fever (CCHF) with magnetic resonance imaging (MRI) in conjunction with clinical and laboratory findings. METHODS: Between July 2015 and August 2016, 36 patients with CCHF were undergone brain MRI including SWI. Two MRIs, one at the time of admission and the second in the convalescent period, were performed for each patient in order to see if there is any sign of central nervous system (CNS) involvement, especially in terms of intracranial haemorrhage or viral encephalitis...
March 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29529977/routine-ct-scanning-of-patients-retrieved-to-a-tertiary-centre-on-veno-venous-extracorporeal-membrane-oxygenation-a-retrospective-risk-benefit-analysis
#17
Kate M Richmond, Katharine G Warburton, Simon J Finney, Sachin Shah, Benjamin A J Reddi
INTRODUCTION: Comprehensive clinical examination can be compromised in patients on veno-venous extracorporeal membrane oxygenation (VV-ECMO). Adjunctive diagnostic imaging strategies range from bedside imaging only to routine computed tomography (CT). The risk-benefit of either approach remains to be evaluated. Patients retrieved to the Royal Brompton Hospital (RBH) on VV-ECMO routinely undergo admission CT imaging of head, chest, abdomen and pelvis. This study aimed to identify how frequently changes in therapy or adverse events could be attributed to routine CT scanning...
March 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29523557/endovascular-treatment-for-acute-ischaemic-stroke-in-routine-clinical-practice-prospective-observational-cohort-study-mr-clean-registry
#18
MULTICENTER STUDY
Ivo G H Jansen, Maxim J H L Mulder, Robert-Jan B Goldhoorn
OBJECTIVE: To determine outcomes and safety of endovascular treatment for acute ischaemic stroke, due to proximal intracranial vessel occlusion in the anterior circulation, in routine clinical practice. DESIGN: Ongoing, prospective, observational cohort study. SETTING: 16 centres that perform endovascular treatment in the Netherlands. PARTICIPANTS: 1488 patients included in the Multicentre Randomised Controlled Trial of Endovascular Treatment for Acute Ischaemic Stroke in the Netherlands (MR CLEAN) Registry who had received endovascular treatment, including stent retriever thrombectomy, aspiration, and all alternative methods for acute ischaemic stroke within 6...
March 9, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29520416/assessment-of-sensitivity-of-whole-body-ct-for-major-trauma
#19
Susan Yoong, Ravi Kothari, Adam Brooks
INTRODUCTION: Whole body computed tomography has become standard practice in many centres in the management of severely injured trauma patients, however, the evidence for it's diagnostic accuracy is limited. AIM: To assess the sensitivity of whole body CT in major trauma. METHOD: Retrospective review of all patients with injury severity score (ISS) > 15 presenting with blunt trauma to a UK Major Trauma Centre between May 2012 and April 2014...
March 8, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29519899/systematic-review-and-meta-analysis-on-outcome-differences-among-patients-with-tici2b-versus-tici3-reperfusions-success-revisited
#20
Johannes Kaesmacher, Tomas Dobrocky, Mirjam R Heldner, Sebastian Bellwald, Pascal J Mosimann, Pasquale Mordasini, Sandra Bigi, Marcel Arnold, Jan Gralla, Urs Fischer
OBJECTIVE: A reperfusion quality of thrombolysis in cerebral infarction (TICI)≥2b has been set as the therapeutic angiography target for interventions in patients with acute ischaemic stroke. This study addresses whether the distinction between TICI2b and TICI3 reperfusions shows a clinically relevant difference on functional outcome. METHODS: A systematic literature review and meta-analysis was carried out and presented in conformity with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria to test the primary hypothesis that TICI2b and TICI3 reperfusions are associated with different rates of modified Rankin Scale (mRS) ≤2 at day 90...
March 8, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
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