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https://www.readbyqxmd.com/read/28734253/polybrominated-diphenyl-ether-flame-retardant-concentrations-in-faeces-from-young-children-in-queensland-australia-and-associations-with-environmental-and-behavioural-factors
#1
Karin English, Yiqin Chen, Leisa-Maree Toms, Paul Jagals, Robert S Ware, Jochen F Mueller, Peter D Sly
The aim of our study was to investigate children's exposure to the flame retardants polybrominated diphenyl ethers (PBDEs) by analysing faecal content, a non-invasive matrix, as well as responses to an exposure-assessment questionnaire. A convenience sample of 61 parents with children (aged >3 months to <2 years) completed an online pre-tested questionnaire and provided faecal samples for analysis by high resolution gas chromatography/mass spectrometry. BDE-209 was the dominant congener in faecal samples adjusted to 8...
July 19, 2017: Environmental Research
https://www.readbyqxmd.com/read/28734244/renal-denervation-attenuates-hypertension-and-renal-dysfunction-in-a-model-of-cardiovascular-and-renal-disease-which-is-associated-with-reduced-nadph-and-xanthine-oxidase-activity
#2
Maria Peleli, Peter Flacker, Zhengbing Zhuge, Cristina Gomez, Craig E Wheelock, A Erik G Persson, Mattias Carlstrom
Oxidative stress is considered a central pathophysiological event in cardiovascular disease, including hypertension. Early age reduction in renal mass is associated with hypertension and oxidative stress in later life, which is aggravated by increased salt intake. The aim of the present study was to examine if renal sympathetic denervation can exert blood pressure lowering effects in uninephrectomized (UNX) rats (3-week old) fed with high salt (HS, 4%; w/w) diet for 4 weeks. Moreover, we investigated if renal denervation is associated with changes in NADPH and xanthine oxidase-derived reactive oxygen species...
July 5, 2017: Redox Biology
https://www.readbyqxmd.com/read/28734242/environmental-estrogen-s-induced-swimming-behavioural-alterations-in-adult-zebrafish-danio-rerio
#3
Basavaraj B Goundadkar, Pancharatna Katti
The present study is an attempt to investigate the effects of long-term (75days) exposure to environmental estrogens (EE) on the swimming behaviour of zebrafish (Danio rerio). Adult zebrafish were exposed semi-statically to media containing commonly detected estrogenic water contaminants (EE2, DES and BPA) at a concentration (5ng/L) much lower than environmentally recorded levels. Time spent in swimming, surface preference, patterns and path of swimming were recorded (6mins) for each fish using two video cameras on day 15, 30 60 and 75...
July 11, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28734231/weight-misperception-and-disordered-weight-control-behaviors-among-u-s-high-school-students-with-overweight-and-obesity-associations-and-trends-1999-2013
#4
Vivienne M Hazzard, Samantha L Hahn, Kendrin R Sonneville
OBJECTIVE: To examine prevalence of weight misperception (incongruence between one's perceived weight status and one's actual weight status) and disordered weight control behaviors (DWCBs; unhealthy behaviors aiming to control or modify weight), associations between weight misperception and DWCBs, and temporal trends in prevalence and associations among adolescents with overweight and obesity from 1999 to 2013. METHODS: Self-reported data from eight biennial cycles (1999-2013) of the cross-sectional national Youth Risk Behavior Survey were used in analyses restricted to respondents with overweight/obesity...
July 13, 2017: Eating Behaviors
https://www.readbyqxmd.com/read/28734211/organotropism-of-methylmercury-in-fish-of-the-southeastern-of-brazil
#5
L S Azevedo, M G Almeida, W R Bastos, M S Suzuki, M C N N Recktenvald, M T S Bastos, C S Vergílio, C M M de Souza
This is one of the first studies to evaluate the effect of biometric variables (total length and weight), diet, and abiotic matrices (sediment and water column) on the bioaccumulation of methylmercury in tissues (muscle, liver, and gills) of four fish (two carnivore-invertivores, Pimelodus fur and Pachyurus adspersus; one carnivore-piscivore, Oligosarcus hepsetus; and one omnivore, Pimelodella lateristriga) in the lower section of a river in southeastern Brazil. Samples of fish (n = 120), water (n = 5) and sediment (n = 5) were collected at five sites characterized by pollution with mercury due to the use of organomercury fungicides and stream bed gold mining, commonly carried out in that section of the river in the 1980s...
July 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28734178/subcortical-surface-shape-in-youth-at-familial-high-risk-for-schizophrenia
#6
Kathryn Hill, Nicolas Bolo, Suraj Sarvode Mothi, Paulo Lizano, Synthia Guimond, Neeraj Tandon, Elena Molokotos, Matcheri Keshavan
Abnormalities in the subcortical brain regions that support cognitive functions have been reported in schizophrenia. Relatives of those with schizophrenia often present with psychosis-like traits (schizotypy) and similar cognition as those with schizophrenia. To evaluate the relationships between subcortical structure, schizotypy, and cognitive function, we assessed shape and volume of the hippocampus, amygdala and thalamus in untreated youth at familial high risk for schizophrenia (HRSZ). The sample consisted of 66 HRSZ and 69 age-matched healthy controls (HC)...
July 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28734173/reliability-and-validity-of-the-tilburg-frailty-indicator-tfi-among-chinese-community-dwelling-older-people
#7
Lijuan Dong, Na Liu, Xiaoyu Tian, Xiaoxia Qiao, Robbert J J Gobbens, Robert L Kane, Cuili Wang
OBJECTIVE: To translate the Tilburg Frailty Indicator (TFI) into Chinese and assess its reliability and validity. METHODS: A sample of 917 community-dwelling older people, aged ≥60 years, in a Chinese city was included between August 2015 and March 2016. Construct validity was assessed using alternative measures corresponding to the TFI items, including self-rated health status (SRH), unintentional weight loss, walking speed, timed-up-and-go tests (TUGT), making telephone calls, grip strength, exhaustion, Short Portable Mental Status Questionnaire (SPMSQ), Geriatric Depression scale (GDS-15), emotional role, Adaptability Partnership Growth Affection and Resolve scale (APGAR) and Social Support Rating Scale (SSRS)...
July 15, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28734154/reducing-alcohol-consumption-to-minimize-weight-gain-and-facilitate-smoking-cessation-among-military-beneficiaries
#8
Mark B Sobell, Alan L Peterson, Linda Carter Sobell, Antoinette Brundige, Christopher M Hunter, Christine M Hunter, Jeffrey L Goodie, Sangeeta Agrawal, Ann S Hrysko-Mullen, William C Isler
INTRODUCTION: Smoking cessation-related weight gain can have significant negative health and career consequences for military personnel. Alcohol reduction combined with smoking cessation may decrease weight gain and relapse. METHOD: A randomized clinical trial of military beneficiaries compared a standard smoking cessation (i.e., brief informational) intervention (N=159), with a brief motivational smoking cessation intervention that emphasized reduced drinking to lessen caloric intake and minimize weight gain (N=158)...
June 30, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28734146/diagnostic-value-of-whole-body-diffusion-weighted-mri-compared-to-computed-tomography-for-pre-operative-assessment-of-patients-suspected-for-ovarian-cancer
#9
Katrijn Michielsen, Raphaëla Dresen, Ragna Vanslembrouck, Frederik De Keyzer, Frédéric Amant, Elvier Mussen, Karin Leunen, Patrick Berteloot, Philippe Moerman, Ignace Vergote, Vincent Vandecaveye
BACKGROUND: Despite excellent per-lesion performance for peritoneal staging, the additional clinical value of diffusion-weighted magnetic resonance imaging (DWI/MRI) compared to computed tomography (CT) remains to be established in ovarian cancer. Our purpose was to evaluate whole body (WB)-DWI/MRI for diagnosis, staging and operability assessment of patients suspected for ovarian cancer compared to CT. METHODS: One hundred and sixty-one patients suspected for ovarian carcinoma underwent 3 T WB-DWI/MRI and contrast-enhanced CT...
July 19, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28734130/right-lobe-living-donors-ages-55-and-older-in-liver-transplantation
#10
Seong Hoon Kim, Eung Chang Lee, Jae Ryong Shim, Sang Jae Park
Insufficient is the evidence for safe use of elderly donors in adult-to-adult living donor liver transplantation (LDLT). The aim of this study was to evaluate the outcomes of right lobe LDLT by donor age (≥55 vs. <55 years). All living donors who underwent right hepatectomy at the authors' institution between March 2008 and December 2015 were divided into 2 groups: group A with an age ≥ 55 and group B with an age < 55. The selection criteria for elderly donor were preservation of middle hepatic vein, remnant liver volume ≥30%, and no or mild fatty liver...
July 22, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28734115/regularized-estimation-in-sparse-high-dimensional-multivariate-regression-with-application-to-a-dna-methylation-study
#11
Haixiang Zhang, Yinan Zheng, Grace Yoon, Zhou Zhang, Tao Gao, Brian Joyce, Wei Zhang, Joel Schwartz, Pantel Vokonas, Elena Colicino, Andrea Baccarelli, Lifang Hou, Lei Liu
In this article, we consider variable selection for correlated high dimensional DNA methylation markers as multivariate outcomes. A novel weighted square-root LASSO procedure is proposed to estimate the regression coefficient matrix. A key feature of this method is tuning-insensitivity, which greatly simplifies the computation by obviating cross validation for penalty parameter selection. A precision matrix obtained via the constrained ℓ1 minimization method is used to account for the within-subject correlation among multivariate outcomes...
July 26, 2017: Statistical Applications in Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28734112/fused-multivariate-empirical-mode-decomposition-memd-and-inverse-solution-method-for-eeg-source-localization
#12
Pegah Khosropanah, Abdul Rahman Ramli, Kheng Seang Lim, Mohammad Hamiruce Marhaban, Anvarjon Ahmedov
EEG source localization is determining possible cortical sources of brain activities with scalp EEG. Generally, every step of the data processing sequence affects the accuracy of EEG source localization. In this paper, we introduce a fused multivariate empirical mode decomposing (MEMD) and inverse solution algorithm with an embedded unsupervised eye blink remover in order to localize the epileptogenic zone accurately. For this purpose, we constructed realistic forward models using MRI and boundary element method (BEM) for each patient to obtain results that are more realistic...
July 22, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28732315/total-and-ionized-magnesium-testing-in-the-surgical-intensive-care-unit-opportunities-for-improved-laboratory-and-pharmacy-utilization
#13
Daniel Dante Yeh, Nalin Chokengarmwong, Yuchiao Chang, Liyang Yu, Colleen Arsenault, Joseph Rudolf, Elizabeth Lee-Lewandrowski, Kent Lewandrowski
PURPOSE: Ionized fraction (iMg) is the physiologically active form of magnesium (Mg); total Mg may not accurately reflect iMg status. Erroneously "low" Mg levels may result in unnecessary repetitive testing. MATERIALS AND METHODS: From 11/2015 to 01/2016, patients ordered for Mg from a pilot ICU also had iMg tested. Weighted kappa statistic was used to assess agreement between Mg categories (low, normal, high). Predictors of unnecessary repeated Mg testing and repletion using data were explored through logistic regression models using GEE techniques to account for repeated measurements in both bivariate and multivariable analyses...
July 11, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28732312/drug-eluting-scaffold-inhibited-in-vivo-pancreatic-tumorigenesis-by-engaging-murine-ccr4-cd8-t-cells
#14
Qian Zhan, Baiyong Shen, Yuan Fang, Xiaxing Deng, Hao Chen, Jiabin Jin, Chenghong Peng, Hongwei Li
CCL17 is well known for its ability to engage CCR4(+)CD8(+) T cells, which have been shown to play a critical role in preventing tumorigenesis. In this study, we attempted to inhibit in vivo pancreatic tumorigenesis by engaging murine CCR4(+)CD8(+) T cells through a drug-eluting scaffold with a payload of CCL17. The drug-eluting scaffold was fabricated by electrospinning polyglyconate and porcine gelatin. The electrospun scaffold featured randomly distributed non-woven fibers with diameters ranging from 1μm to 4μm...
July 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28732281/epileptic-seizure-detection-in-eegs-signals-based-on-the-weighted-visibility-graph-entropy
#15
Zeynab Mohammadpoory, Mahda Nasrolahzadeh, Javad Haddadnia
PURPOSE: Epileptic seizure detection has been a complex task for both researchers and specialist in that the assessment of epilepsy is difficult because, electroencephalogram (EEG) signals are chaotic and non-stationary. METHOD: This paper proposes a new method based on weighted visibility graph entropy (WVGE) to identify seizure from EEG signals. Single channel EEG signals are mapped onto the WVGs and WVGEs are calculated from these WVGs. Then some features are extracted of WVGEs and given to classifiers to investigate the performance of these features to classify the brain signals into three groups of normal (healthy), seizure free (interictal) and during a seizure (ictal) groups...
July 11, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28732251/nutrient-deficiency-and-obstetrical-outcomes-in-pregnant-women-following-roux-en-y-gastric-bypass-a-retrospective-danish-cohort-study-with-a-matched-comparison-group
#16
Lianna Hede Hammeken, Ramsina Betsagoo, Ann Nygaard Jensen, Anne Nødgaard Sørensen, Charlotte Overgaard
OBJECTIVE: Roux-en-Y gastric bypass surgery and small-for-gestational-age births are known to be associated although the etiology is not fully understood. This study aimed to investigate pregnancy outcomes and maternal nutritional status among pregnant women with a history of Roux-en-Y gastric bypass using maternal anemia and gestational weight gain as indicators of micronutrient and macronutrient deficiency in pregnancy. STUDY DESIGN: The study was designed as a retrospective matched cohort study...
July 12, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28732218/invasiveness-of-tibial-bone-graft-harvesting-for-secondary-alveolar-bone-grafting-can-harvesting-be-made-at-the-age-of-less-than-10%C3%A2-years-without-complications
#17
Kohta Fukuta, Kenichi Kurita, Atsushi Nakayama, Masahito Maeda, Hiroshi Watanabe, Mitsuo Goto
PURPOSE: In this study, particulate cancellous bone marrow was harvested from the tibia for alveolar bone grafting, and postoperative complications at the donor site were compared between patients aged 10 years or older (29 tibias) and those aged younger than 10 years (42 tibias). PATIENTS AND METHODS: Enrolled patients were those who underwent tibial bone graft harvesting at the Department of Oral and Maxillofacial Surgery, Aichi Gakuin University, during a period of 3 years and 1 month from March 2012 through March 2015...
June 24, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28732212/ualcan-a-portal-for-facilitating-tumor-subgroup-gene-expression-and-survival-analyses
#18
Darshan S Chandrashekar, Bhuwan Bashel, Sai Akshaya Hodigere Balasubramanya, Chad J Creighton, Israel Ponce-Rodriguez, Balabhadrapatruni V S K Chakravarthi, Sooryanarayana Varambally
Genomics data from The Cancer Genome Atlas (TCGA) project has led to the comprehensive molecular characterization of multiple cancer types. The large sample numbers in TCGA offer an excellent opportunity to address questions associated with tumo heterogeneity. Exploration of the data by cancer researchers and clinicians is imperative to unearth novel therapeutic/diagnostic biomarkers. Various computational tools have been developed to aid researchers in carrying out specific TCGA data analyses; however there is need for resources to facilitate the study of gene expression variations and survival associations across tumors...
July 18, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28732187/do-genetic-markers-of-inflammation-modify-the-relationship-between-periodontitis-and-nonalcoholic-fatty-liver-disease-findings-from-the-ship-study
#19
A A Akinkugbe, C L Avery, A S Barritt, S R Cole, M Lerch, J Mayerle, S Offenbacher, A Petersmann, M Nauck, H Völzke, G D Slade, G Heiss, T Kocher, B Holtfreter
An association between periodontitis and nonalcoholic fatty liver disease (NAFLD) has been reported by experimental animal and epidemiologic studies. This study investigated whether circulating levels of serum C-reactive protein (CRP) and a weighted genetic CRP score representing markers of inflammatory burden modify the association between periodontitis and NAFLD. Data came from 2,481 participants of the Study of Health in Pomerania who attended baseline examination that occurred between 1997 and 2001. Periodontitis was defined as the percentage of sites (0%, <30%, ≥30%) with probing pocket depth (PD) ≥4 mm, and NAFLD status was determined using liver ultrasound assessment...
July 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28732106/specific-%C3%AE-7-nicotinic-acetylcholine-receptor-agonist-ameliorates-isoproterenol-induced-cardiac-remodeling-in-mice-through-tgf-%C3%AE-1-smad3-pathway
#20
Yong-Hua Yang, Huan-Le Fang, Ming Zhao, Xiang-Lan Wei, Ning Zhang, Shun Wang, Yi Lu, Xiao-Jiang Yu, Lei Sun, Xi He, Dong-Ling Li, Jin-Jun Liu, Wei-Jin Zang
It is well-accepted that inflammation plays an important role in the development of cardiac remodeling and that therapeutic approaches targeting inflammation can inhibit cardiac remodeling. Although a large amount of evidence indicates that activation of α7 nicotinic acetylcholine receptor (α7nAChR) causes an anti-inflammatory effect, the role of α7nAChR in cardiac remodeling and the underlying mechanism have not been established. To investigate the effect of the specific α7nAChR agonist, PNU282987, on cardiac remodeling induced by isoproterenol (ISO 60 mg/kg/d) in mice, the cardiomyocyte cross-sectional area (CSA) and collagen volume fraction were evaluated by hematoxylin and eosin (HE) and Masson staining, respectively...
July 21, 2017: Clinical and Experimental Pharmacology & Physiology
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