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https://www.readbyqxmd.com/read/28103589/the-effects-of-body-mass-index-on-second-trimester-amniotic-fluid-cytokine-and-matrix-metalloproteinase-levels
#1
Rauf Melekoglu, Osman Ciftci, Sevil Eraslan, Nese Basak, Ebru Celik
AIM: The aim of this study was to determine the effects of obesity on amniotic fluid (AF) inflammatory markers in second-trimester AF, testing the hypothesis that there is a relationship between maternal body mass index (BMI) and fetal inflammatory exposure. METHODS: AF was obtained from 84 singleton pregnant women undergoing elective amniocentesis for karyotype analysis at 16-24 weeks of gestation between April 2014 and May 2016. The cell-free AF was used to analyze interleukin (IL)-1β and IL-6, and matrix metalloproteinase (MMP)-1, MMP-6, and MMP-13...
January 20, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28103579/the-combination-of-early-treatment-response-and-ypt-stage-is-a-novel-metric-to-stage-rectal-cancer-patients-treated-with-neoadjuvant-chemoradiotherapy
#2
Jian Cui, Lin Yang, Lei Guo, Yongfu Shao, Dongfeng Tan, Ni Li, Haizeng Zhang
Rectal cancer patients receiving neoadjuvant chemoradiotherapy (NCRT) are currently classified using the same Tumor-Node-Metastasis staging system as those patients without NCRT. We determined whether the combination of tumor treatment response (TRG) and ypT stage more accurately assesses primary tumors in rectal cancer after NCRT. We analyzed data from 329 rectal cancer patients treated with NCRT followed by radical resection. Cox proportional hazards models were used to evaluate the effects of different staging parameters on disease-free survival (DFS)...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28103565/a-scan-line-forest-growing-based-hand-segmentation-framework-with-multipriority-vertex-stereo-matching-for-wearable-devices
#3
Yiyi Ren, Xiang Xie, Guolin Li, Zhihua Wang
A hand segmentation framework is proposed for 3-D hand gesture interaction for wearable devices. In this framework, all the objects in a scene are regarded as directed trees in a forest, and the problem of the hand segmentation can be converted into finding the target tree (called hand tree) in the forest with proper hand properties including color consistency, space consistency, disparity, and hand shape constraints. The forest grows scan-line by scan-line from high reliable regions to low reliable regions...
January 16, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28103556/steerable-wavelet-machines-swm-learning-moving-frames-for-texture-classification
#4
Adrien Depeursinge, Zsuzsanna Puspoki, John Paul Ward, Michael Unser
We present texture operators encoding classspecific local organizations of image directions (LOID) in a rotation-invariant fashion. The LOIDs are key for visual understanding, and are at the origin of the success of the popular approaches such as local binary patterns (LBP) and the scaleinvariant feature transform (SIFT). Whereas LBPs and SIFT yield handcrafted image representations, we propose to learn dataspecific representations of the LOIDs in a rotation-invariant fashion. The image operators are based on steerable circular harmonic wavelets (CHW), offering a rich and yet compact initial representation for characterizing natural textures...
January 18, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28103462/low-adherence-to-mediterranean-diet-in-portugal-pregnant-women-nutrition-in-portugal-and-its-repercussions
#5
REVIEW
Luis Pereira-da-Silva, Elisabete Pinto
INTRODUCTION: Portuguese population is drifting away from the Mediterranean diet-like pattern. In this context, the current nutritionalstatus of women of childbearing age and of pregnant Portuguese women and their growing fetuses is critically reviewed. MATERIAL AND METHODS: A narrative critical review was performed on recent published high quality studies assessing diet and nutritional status of women of childbearing age and pregnant women and its influence on the nutritional status of their offspring...
October 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28103456/health-inequalities-in-diabetes-mellitus-and-hypertension-a-parish-level-study-in-the-northern-region-of-portugal
#6
Teresa Leao, Julian Perelman, Manuela Felício, Vasco Machado, Graça Lima
INTRODUCTION: Diabetes and hypertension are highly prevalent conditions in Portugal. Little is known about the geographical and social patterning of these diseases, which precludes the design of targeted health policies. This study aimed to measure the geographical and socioeconomic distribution of type 2 diabetes and hypertension prevalence in the population resident in the Northern region of Portugal, for the year 2013. MATERIAL AND METHODS: An ecological correlation study analyzed the 2,028 parishes of the region...
October 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28103448/bedside-contribution-of-electrical-impedance-tomography-to-set-positive-end-expiratory-pressure-for-ecmo-treated-severe-ards-patients
#7
Guillaume Franchineau, Nicolas Bréchot, Guillaume Lebreton, Guillaume Hekimian, Ania Nieszkowska, Jean-Louis Trouillet, Pascal Leprince, Jean Chastre, Charles-Edouard Luyt, Alain Combes, Matthieu Schmidt
RATIONALE: Optimal positive end-expiratory pressure (PEEP) is unknown in severe acute respiratory distress syndrome (ARDS) patients on extracorporeal membrane oxygenation (ECMO) receiving mechanical ventilation with very low tidal volume. OBJECTIVES: To evaluate electrical impedance tomography's (EIT) ability to monitor a PEEP trial and to derive from EIT the best compromise PEEP in this setting. METHODS: A decremental PEEP trial (20-0 cmH2O) in 5 cmH2O steps was monitored by EIT, with lung images divided into four ventral-to-dorsal horizontal regions of interest...
January 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28103443/effects-of-childhood-asthma-on-the-development-of-obesity-among-school-aged-children
#8
Zhanghua Chen, Muhammad T Salam, Tanya L Alderete, Rima Habre, Theresa M Bastain, Kiros Berhane, Frank D Gilliland
RATIONALE: Asthma and obesity often occur together in children. It is unknown whether asthma contributes to the childhood obesity epidemic. OBJECTIVES: We aimed to investigate the effects of asthma and asthma medication use on the development of childhood obesity. METHODS: The primary analysis was conducted among 2,171 non-obese children who were 5-8 years of age at study enrollment in the Southern California Children's Health Study (CHS) and were followed for up to 10 years...
January 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28103417/diabetes-as-a-risk-factor-for-acute-coronary-syndrome-in-women-compared-with-men-a-meta-analysis-including-10-856-279-individuals-and-106-703-acute-coronary-syndrome-events
#9
Xue Dong, Rongrong Cai, Jie Sun, Rong Huang, Pin Wang, Haixia Sun, Sai Tian, Shaohua Wang
BACKGROUND: Diabetes mellitus is a significant cause of death and disability worldwide and is a strong risk factor for acute coronary syndrome (ACS). Whether diabetes confers the same excess risk of ACS in both sexes is unknown. Therefore, we undertook a meta-analysis to estimate the relative risk for ACS associated with diabetes in men and women. METHODS: We systematically searched PubMed, Embase, and Cochrane Library databases for both case-control and cohort studies published between Jan 1, 1966, and Jan 1, 2015...
January 19, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28103322/htlv-1-tax-induces-formation-of-the-active-macromolecular-ikk-complex-by-generating-lys63-and-met1-linked-hybrid-polyubiquitin-chains
#10
Yuri Shibata, Fuminori Tokunaga, Eiji Goto, Ginga Komatsu, Jin Gohda, Yasushi Saeki, Keiji Tanaka, Hirotaka Takahashi, Tatsuya Sawasaki, Satoshi Inoue, Hiroyuki Oshiumi, Tsukasa Seya, Hiroyasu Nakano, Yuetsu Tanaka, Kazuhiro Iwai, Jun-Ichiro Inoue
The Tax protein of human T-cell leukemia virus type 1 (HTLV-1) is crucial for the development of adult T-cell leukemia (ATL), a highly malignant CD4+ T cell neoplasm. Among the multiple aberrant Tax-induced effects on cellular processes, persistent activation of transcription factor NF-κB, which is activated only transiently upon physiological stimulation, is essential for leukemogenesis. We and others have shown that Tax induces activation of the IκB kinase (IKK) complex, which is a critical step in NF-κB activation, by generating Lys63-linked polyubiquitin chains...
January 19, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28103297/obesity-in-french-inmates-gender-differences-and-relationship-with-mood-eating-behavior-and-physical-activity
#11
Aude Lagarrigue, Soufiane Ajana, Lucile Capuron, Catherine Féart, Marie-Pierre Moisan
CONTEXT: Inmates, notably women, are at greater risk for obesity and metabolic complications than the general population according to several studies from high income countries. Data regarding French correctional institutions are lacking so far. To fill this gap, we have assessed in a sample from a French prison (33 females and 18 males) the gender-specific effect of incarceration on weight and body mass index (BMI) and examined their current metabolic status. Furthermore, to reveal the possible determinants of increased obesity, we analyzed emotional vulnerability, eating behavior and physical activity using self-reported questionnaires...
2017: PloS One
https://www.readbyqxmd.com/read/28103265/rabbit-model-of-human-gliomas-implications-for-intra-arterial-drug-delivery
#12
Huamin Qin, Miroslaw Janowski, Monica S Pearl, Izabela Malysz-Cymborska, Shen Li, Charles G Eberhart, Piotr Walczak
The prognosis for malignant brain tumors remains poor despite a combination of surgery, radiotherapy, and chemotherapy. This is partly due to the blood-brain barrier, a major obstacle that prevents therapeutic agents from effectively reaching the tumor. We have recently developed a method for precise and predictable opening of the blood-brain barrier via the intra-arterial administration of mannitol, a hyperosmolar agent, in a rabbit model, whose vascular anatomy facilitates the use of standard interventional neuroradiology techniques and devices...
2017: PloS One
https://www.readbyqxmd.com/read/28103256/tumor-infiltration-in-enhancing-and-non-enhancing-parts-of-glioblastoma-a-correlation-with-histopathology
#13
Oliver Eidel, Sina Burth, Jan-Oliver Neumann, Pascal J Kieslich, Felix Sahm, Christine Jungk, Philipp Kickingereder, Sebastian Bickelhaupt, Sibu Mundiyanapurath, Philipp Bäumer, Wolfgang Wick, Heinz-Peter Schlemmer, Karl Kiening, Andreas Unterberg, Martin Bendszus, Alexander Radbruch
PURPOSE: To correlate histopathologic findings from biopsy specimens with their corresponding location within enhancing areas, non-enhancing areas and necrotic areas on contrast enhanced T1-weighted MRI scans (cT1). MATERIALS AND METHODS: In 37 patients with newly diagnosed glioblastoma who underwent stereotactic biopsy, we obtained a correlation of 561 1mm3 biopsy specimens with their corresponding position on the intraoperative cT1 image at 1.5 Tesla. Biopsy points were categorized as enhancing (CE), non-enhancing (NE) or necrotic (NEC) on cT1 and tissue samples were categorized as "viable tumor cells", "blood" or "necrotic tissue (with or without cellular component)"...
2017: PloS One
https://www.readbyqxmd.com/read/28103254/a-highly-active-endo-levanase-bt1760-of-a-dominant-mammalian-gut-commensal-bacteroides-thetaiotaomicron-cleaves-not-only-various-bacterial-levans-but-also-levan-of-timothy-grass
#14
Karin Mardo, Triinu Visnapuu, Heiki Vija, Anneli Aasamets, Katrin Viigand, Tiina Alamäe
Bacteroides thetaiotaomicron, an abundant commensal of the human gut, degrades numerous complex carbohydrates. Recently, it was reported to grow on a β-2,6-linked polyfructan levan produced by Zymomonas mobilis degrading the polymer into fructooligosaccharides (FOS) with a cell surface bound endo-levanase BT1760. The FOS are consumed by B. thetaiotaomicron, but also by other gut bacteria, including health-promoting bifidobacteria and lactobacilli. Here we characterize biochemical properties of BT1760, including the activity of BT1760 on six bacterial levans synthesized by the levansucrase Lsc3 of Pseudomonas syringae pv...
2017: PloS One
https://www.readbyqxmd.com/read/28103249/the-green-tea-catechin-epigallocatechin-gallate-ameliorates-graft-versus-host-disease
#15
Sabine Westphal, Aleixandria McGeary, Sandra Rudloff, Andrea Wilke, Olaf Penack
Allogeneic hematopoetic stem cell transplantation (allo-HSCT) is a standard treatment for leukemia and other hematologic malignancies. The major complication of allo-HSCT is graft-versus-host-disease (GVHD), a progressive inflammatory illness characterized by donor immune cells attacking the organs of the recipient. Current GVHD prevention and treatment strategies use immune suppressive drugs and/or anti-T cell reagents these can lead to increased risk of infections and tumor relapse. Recent research demonstrated that epigallocatechin gallate (EGCG), a component found in green tea leaves at a level of 25-35% at dry weight, may be useful in the inhibition of GVHD due to its immune modulatory, anti-oxidative and anti-angiogenic capacities...
2017: PloS One
https://www.readbyqxmd.com/read/28103233/evaluation-of-a-smartphone-decision-support-tool-for-diarrheal-disease-management-in-a-resource-limited-setting
#16
Farhana Haque, Robyn L Ball, Selina Khatun, Mujaddeed Ahmed, Saraswati Kache, Mohammod Jobayer Chisti, Shafiqul Alam Sarker, Stace D Maples, Dane Pieri, Teja Vardhan Korrapati, Clea Sarnquist, Nancy Federspiel, Muhammad Waliur Rahman, Jason R Andrews, Mahmudur Rahman, Eric Jorge Nelson
The emergence of mobile technology offers new opportunities to improve clinical guideline adherence in resource-limited settings. We conducted a clinical pilot study in rural Bangladesh to evaluate the impact of a smartphone adaptation of the World Health Organization (WHO) diarrheal disease management guidelines, including a modality for age-based weight estimation. Software development was guided by end-user input and evaluated in a resource-limited district and sub-district hospital during the fall 2015 cholera season; both hospitals lacked scales which necessitated weight estimation...
January 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28103207/determination-of-factors-affecting-physical-activity-status-of-university-students-on-a-health-sciences-campus
#17
Ayfer Dayi, Ayla Acikgoz, Guven Guvendi, Levent Bayrak, Burcu Ersoy, Cagri Gur, Omer Ozmen
Upon graduation, students studying in departments related to health will work in the health sector and will guide and enlighten people with their knowledge and behavior. The purpose of this study was to determine the factors affecting the physical activity (PA) conditions of university students on a health sciences campus. A cross-sectional study was carried out on 706 students in a Turkish university. The data was obtained from a survey prepared by the researchers. The 26-question survey aimed to discover the students' socio-demographic characteristics and their awareness and practices concerning PA...
January 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28103198/harmonious-genetic-clustering
#18
Faliang Huang, Xuelong Li, Shichao Zhang, Jilian Zhang
To automatically determine the number of clusters and generate more quality clusters while clustering data samples, we propose a harmonious genetic clustering algorithm, named HGCA, which is based on harmonious mating in eugenic theory. Different from extant genetic clustering methods that only use fitness, HGCA aims to select the most suitable mate for each chromosome and takes into account chromosomes gender, age, and fitness when computing mating attractiveness. To avoid illegal mating, we design three mating prohibition schemes, i...
January 5, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28103193/comprehensive-use-of-curvature-for-robust-and-accurate-online-surface-reconstruction
#19
Damien Lefloch, Markus Kluge, Hamed Sarbolandi, Tim Weyrich, Andreas Kolb
Interactive real-time scene acquisition from hand-held depth cameras has recently developed much momentum, enabling applications in ad-hoc object acquisition, augmented reality and other fields. A key challenge to online reconstruction remains error accumulation in the reconstructed camera trajectory, due to drift-inducing instabilities in the range scan alignments of the underlying iterative-closest-point (ICP) algorithm. Various strategies have been proposed to mitigate that drift, including SIFT-based pre-alignment, color-based weighting of ICP pairs, stronger weighting of edge features, and so on...
January 5, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28103183/association-between-parent-television-viewing-practices-and-setting-rules-to-limit-the-television-viewing-time-of-their-8-to-12-year-old-children-minnesota-2011-2015
#20
Martha Y Kubik, Olga V Gurvich, Jayne A Fulkerson
INTRODUCTION: Television (TV) viewing is popular among adults and children, and child TV-viewing time is positively associated with parent TV-viewing time. Efforts to limit the TV-viewing time of children typically target parent rule-setting. However, little is known about the association between parent TV-viewing practices and rule-setting. METHODS: We used baseline height and weight data and survey data collected from 2011 through 2015 on parents and their 8- to 12-year-old children (N = 212 parent/child dyads) who were participants in 2 community-based obesity prevention intervention trials conducted in metropolitan Minnesota...
January 19, 2017: Preventing Chronic Disease
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