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Graciela Araújo Do Espírito-Santo, Diniz Pereira Leite, Hugo Dias Hoffmann-Santos, Luciana Basili Dias, Rosane Christine Hahn
Onychomycosis is an infection of the nail plate by fungal microorganisms. This infection has an important social impact on women and men and poses a major challenge for its treatment. The traditional treatment of onychomycosis involves the use of topical and oral antifungal agents. However, the presence of adverse effects frequently associated with oral antifungals, their high cost, and their potential interactions with other drugs reflect some of the problems associated with conventional therapy. The current report details the evaluation of a 1340nm laser as monotherapy for toenails affected by onychomycosis...
August 2017: Journal of Clinical and Aesthetic Dermatology
Ahmed El Gamal, Jean Paul Rocca, Carlo Fornaini, Etienne Medioni, Nathalie Brulat-Bouchard
BACKGROUND AND AIMS: The aim of this study was to measure the microhardness values of irradiated computer-aided design/computer-aided manufacturing (CAD/CAM) ceramics surfaces before and after thermal treatment. MATERIALS AND METHODS: Sixty CAD/CAM ceramic discs were prepared and grouped by material, i.e. lithium disilicate ceramic (Emax CAD) and zirconia ceramic (Emax ZirCAD). Laser irradiation at the material surface was performed with a carbon dioxide laser at 5 Watt (W) or 10 W power in continuous mode (CW mode), or with a neodymium:yttrium aluminum perovskite (Nd:YAP) laser at 10 W on graphite and non-graphite surfaces...
March 31, 2017: Laser Therapy
Zeming Liu, Wen Zeng, Yusufu Maimaiti, Jie Ming, Yawen Guo, Yan Liu, Chunping Liu, Tao Huang
CONTEXT: The Hippo signal transduction pathway is highly conserved in mammals. It plays a critical role in tissue and organ size by regulating the balance between cell proliferation and apoptosis. However, there have been few reports concerning Yes-activated protein-1 (YAP-1) elevation in papillary thyroid cancer (PTC). OBJECTIVE: The objective of this study was to determine whether YAP-1 expression is a biomarker and high-risk clinicopathologic prognosticator in PTC...
July 4, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
Yu Gu, Hiran Perinpanayagam, David J W Kum, Yeon-Jee Yoo, Jin-Sun Jeong, Sang-Min Lim, Seok-Woo Chang, Seung-Ho Baek, Qiang Zhu, Kee-Yeon Kum
OBJECTIVE: The aim of this study was to compare the effectiveness of five intracanal agitation techniques on the penetration of irrigant and sealer into dentinal tubules. BACKGROUND DATA: Intracanal agitation techniques could promote chemomechanical debridement and the sealing of root canals during endodontic treatment. However, there is limited evidence for the agitation effect of Nd:YAP laser. MATERIALS AND METHODS: Human maxillary premolars with single straight canals (N = 60) were prepared with ProTaper Next(®) NiTi rotary files (Dentsply Maillefer) up to X4 (ISO 40 size)...
February 2017: Photomedicine and Laser Surgery
Sandro Zambito-Marsala, Roberto Erro, Ruggero Bacchin, Annalisa Fornasier, Federico Fabris, Cecilia Lo Cascio, Franco Ferracci, Francesca Morgante, Michele Tinazzi
BACKGROUND: Several studies documented abnormal nociceptive processing in PD patients. Pain central pathways are accessible by laser-evoked potentials (LEPs). LEPs recording show a N2/P2 complex mostly generated by the anterior cingulate cortex, preceded by an earlier negative component (N1), originating from the opercular cortex. Previous work demonstrated N2/P2 amplitude reduction in PD patients and suggested a centrally-acting pathomechanism for the genesis of pain. However, since a peripheral deafferentation has been recently demonstrated in PD, it is not clear if such LEP abnormalities reflect a mechanism acting centrally or not...
January 2017: Parkinsonism & related Disorders
Baris Isak, Hatice Tankisi, Birger Johnsen, Kirsten Pugdahl, Nanna Brix Finnerup, Anders Fuglsang-Frederiksen
OBJECTIVE: Mild involvement of sensory nerves has been reported in previous studies in ALS patients. In this study, we assessed sensory pathways in ALS patients using laser evoked potentials (LEPs) and somatosensory evoked potentials (SSEPs). METHODS: We recruited 18 ALS patients and 31 healthy subjects. Neodymium-doped yttrium aluminium perovskite (Nd:YAP)-laser was used to evoke LEPs in upper (UE) and lower (LE) extremities. N1 and N2P2 potentials were obtained from contralateral insular cortex (T3 or T4) and vertex (Cz), respectively...
October 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
A Namour, S Geerts, T Zeinoun, R De Moor, S Nammour
Objective. Nd:YAP laser has several potentialities of clinical applications in endodontics. The aim of our study is to determine the safety range of irradiation parameters during endodontic application of Nd:YAP laser that can be used without damaging and overheating the periodontal tissue. Material and Methods. Twenty-seven caries-free single-rooted extracted human teeth were used. Crowns were sectioned to obtain 11 mm root canal length. Temperature increases at root surfaces were measured by a thermocouple during Nd:YAP laser irradiation of root canals at different energy densities...
2016: BioMed Research International
Weijie Nie, Ruiyun He, Chen Cheng, Uéslen Rocha, Javier Rodríguez Vázquez de Aldana, Daniel Jaque, Feng Chen
We report on the fabrication of optical lattice-like waveguide structures in an Nd:YAP laser crystal by using direct femtosecond laser writing. With periodically arrayed laser-induced tracks, the waveguiding cores can be located in either the regions between the neighbored tracks or the central zone surrounded by a number of tracks as outer cladding. The polarization of the femtosecond laser pulses for the inscription has been found to play a critical role in the anisotropic guiding behaviors of the structures...
May 15, 2016: Optics Letters
Ahmed El Gamal, Carlo Fornaini, Jean Paul Rocca, Omid H Muhammad, Etienne Medioni, Annamaria Cucinotta, Nathalie Brulat-Bouchard
BACKGROUND AND AIMS: The objective of this study was to investigate the interaction of infrared laser light on Computer Aided Design and Computer Aided Manufacturing (CAD/CAM) ceramic surfaces. MATERIAL AND METHODS: Sixty CAD/CAM ceramic discs were prepared and divided into two different groups: lithiumdisilicate ceramic (IPSe.maxCADs) and Zirconia ceramic (IPSe.maxZirCADs). The laser irradiation was performed on graphite and non-graphite surfaces with a Carbon Dioxide laser at 5W and 10W power in continuous mode (CW mode) and with Neodymium Yttrium Aluminum Perovskite (Nd:YAP) laser at 10W...
March 31, 2016: Laser Therapy
Victoria J Madden, Mark J Catley, Luzia Grabherr, Francesca Mazzola, Mohammad Shohag, G Lorimer Moseley
Background. Nd:YAP laser is widely used to investigate the nociceptive and pain systems, generating perpetual and laser-evoked neurophysiological responses. A major procedural concern for the use of Nd:YAP laser stimuli in experimental research is the risk of skin damage. The absorption of Nd:YAP laser stimuli is greater in darker skin, or in pale skin that has been darkened with ink, prompting some ethics boards to refuse approval to experimenters wishing to track stimulus location by marking the skin with ink...
2016: PeerJ
Weijie Nie, Chen Cheng, Yuechen Jia, Carolina Romero, Javier R Vázquez de Aldana, Feng Chen
Low-loss depressed cladding waveguides have been produced in Nd:YAP laser crystal by using direct femtosecond laser writing. Under optical pump at 812 nm at room temperature, continuous-wave simultaneous dual-wavelength laser oscillations at 1064 and 1079 nm, both along TM polarization, have been realized in the waveguiding structures. It has been found that, with the variation of pump polarization, the intensity ratio of 1064 and 1079 nm emissions varies periodically, while the polarization of output dual-wavelength laser remains unchanged...
May 15, 2015: Optics Letters
Y J Huang, Y F Chen, W D Chen, G Zhang
We report on a diode-pumped, Q-switched intracavity-Raman-shifted Nd-doped yttrium-aluminum-perovskite (Nd:YAP) laser using potassium titanyl phosphate (KTP) or potassium titanyl arsenate (KTA) nonlinear crystals to produce eye-safe radiation. In both cases, we obtained simultaneous laser emission at two wavelengths corresponding to distinct Raman gain peaks and different Stokes orders for the nonlinear crystal used. From the Nd:YAP/KTP laser source, we obtained 3 ns pulses of combined 21 kW peak power at 1478 and 1503 nm...
August 1, 2015: Optics Letters
Antoine Reginensi, Masato Hoshi, Sami Kamel Boualia, Maxime Bouchard, Sanjay Jain, Helen McNeill
Despite the high occurrence of congenital abnormalities of the lower urinary tract in humans, the molecular, cellular and morphological aspects of their development are still poorly understood. Here, we use a conditional knockout approach to inactivate within the nephric duct (ND) lineage the two effectors of the Hippo pathway, Yap and Taz. Deletion of Yap leads to hydronephrotic kidneys with blind-ending megaureters at birth. In Yap mutants, the ND successfully migrates towards, and contacts, the cloaca. However, close analysis reveals that the tip of the Yap(-/-) ND forms an aberrant connection with the cloaca and does not properly insert into the cloaca, leading to later detachment of the ND from the cloaca...
August 1, 2015: Development
Y J Huang, Y F Chen, W D Chen, G Zhang
Extending the spectral wavelengths of the diode-pumped Nd-doped lasers at 1.3 μm with the KTP crystal in the intracavity Raman configuration is reported for the first time to the best of our knowledge. A systematic comparison is performed to show that a better optical conversion efficiency for the Nd:YAP/KTP Raman laser could be achieved thanks to the higher peak power and linearly polarized radiation at 1341 nm, whereas up to four Stokes emission lines are generated from the Nd:YAG/KTP Raman laser as a result of the fundamental dual-color operation at 1319 and 1338 nm...
April 20, 2015: Optics Express
Qinghe Song, Beibei Mao, Jinbo Cheng, Yuhao Gao, Ke Jiang, Jun Chen, Zengqiang Yuan, Songshu Meng
The Yes-associated protein (YAP), a transcriptional coactivator inactivated by the Hippo tumor suppressor pathway, functions as an oncoprotein in a variety of cancers. However, its contribution to breast cancer remains controversial. This study investigated the role of YAP in breast cancer cells under nutrient deprivation (ND). Here, we show that YAP knockdown sensitized MCF7 breast cancer cells to nutrient deprivation-induced apoptosis. Furthermore, in response to ND, YAP increased the autolysosome degradation, thereby enhancing the cellular autophagic flux in breast cancer cells...
2015: PloS One
Tommaso Bocci, Enrica Santarcangelo, Beatrice Vannini, Antonio Torzini, Giancarlo Carli, Roberta Ferrucci, Alberto Priori, Massimiliano Valeriani, Ferdinando Sartucci
PURPOSE: The cerebellum is involved in a wide number of integrative functions, but its role in pain experience and in the nociceptive information processing is poorly understood. In healthy volunteers we evaluated the effects of transcranial cerebellar direct current stimulation (tcDCS) by studying the changes in the perceptive threshold, pain intensity at given stimulation intensities (VAS:0-10) and laser evoked potentials (LEPs) variables (N1 and N2/P2 amplitudes and latencies). METHODS: Fifteen subjects were studied before and after anodal, cathodal and sham tcDCS...
2015: Restorative Neurology and Neuroscience
Amin Joukar, Erfan Nammakie, Hanieh Niroomand-Oscuii
The application of laser in ophthalmology and eye surgery is so widespread that hardly can anyone deny its importance. On the other hand, since the human eye is an organ susceptible to external factors such as heat waves, laser radiation rapidly increases the temperature of the eye and therefore the study of temperature distribution inside the eye under laser irradiation is crucial; but the use of experimental and invasive methods for measuring the temperature inside the eye is typically high-risk and hazardous...
April 2015: Journal of Thermal Biology
Seyyed Abbas Mirnezami, Mahdi Rajaei Jafarabadi, Maryam Abrishami
INTRODUCTION: Human eye is a sensitive part of human body with no direct protection and due to its lack of protection against the external heat waves, studying the temperature distribution of heat waves on the human eye is of utmost importance. Various lasers are widely used in medical applications such as eye surgeries. The most significant issue in the eye surgeries with laser is estimation of temperature distribution and its increase in eye tissues due to the laser radiation intensity...
2013: Journal of Lasers in Medical Sciences
Amaury Namour, Samir Nammour, André Peremans, Daniel Heysselaer, Roeland J G De Moor
OBJECTIVE: The aim of this study is to evaluate the effectiveness of Nd:YAP laser to seal dentinal tubules at different parameters. MATERIAL AND METHODS: 24 caries-free human wisdom impacted molars were used. The crowns were sectioned transversally in order to totally expose the dentin. The smear layer was removed by a 1 min application of EDTA. Each surface was divided into four quadrants, but only three quadrants were irradiated at a different output power setting (irradiation speed: 1 mm/sec; optical fiber diameter: 320 µm; tangential incidence of beam and in noncontact mode)...
2014: TheScientificWorldJournal
Yanfei Lü, Jing Xia, Jing Zhang, Xihong Fu, Huilong Liu
We report a diode-pumped continuous wave (cw) orthogonally polarized dual-wavelength laser at 1339 and 1341 nm with a single b-cut Nd:YAlO(3) (Nd:YAP) crystal. By adjusting the tilt angle of the uncoated glass plate inserted in the laser cavity, we can control the cavity losses of two polarized directions. The output wavelengths are 1339 nm in a-axis polarization and 1341 nm in c-axis polarization, respectively, which are orthogonal to each other. At an incident pump power of 17.3 W, the cw output power obtained at 1339 and 1341 nm is 1...
August 10, 2014: Applied Optics
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