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https://www.readbyqxmd.com/read/29166561/structural-characterization-of-native-and-modified-encapsulins-as-nanoplatforms-for-in-vitro-catalysis-and-cellular-uptake
#1
Rindia M Putri, Carolina Allende-Ballestero, Daniel Luque, Robin Klem, Katerina-Asteria Rousou, Aijie Liu, Christoph H-H Traulsen, W Frederik Rurup, Melissa S T Koay, Jose R Castón, Jeroen J L M Cornelissen
Recent years have witnessed the emergence of bacterial semi-organelle encapsulins as promising platforms for bio-nanotechnology. To advance the development of encapsulins as nanoplatforms, a functional and structural basis of these assemblies is required. Encapsulin from Brevibacterium linens is known to be a protein-based vessel for an enzyme cargo in its cavity, which could be replaced with a foreign cargo resulting in a modified encapsulin. Here, we characterize the native structure of B. linens encapsulins with both native and foreign cargo using cryo-electron microscopy (cryo-EM)...
November 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/29166538/antimicrobial-photodynamic-therapy-associated-with-conventional-endodontic-treatment-a-clinical-and-molecular-microbiological-study
#2
Caroline C da Silva, Sérgio P Chaves Júnior, Gabriela L D Pereira, Karla B F C da Fontes, Lívia A A Antunes, Helvécio C C Póvoa, Leonardo S Antunes, Natalia L P Póvoa Iorio
This study evaluated antimicrobial photodynamic therapy (aPDT) as an adjunct to endodontic treatment. Ten uniradicular teeth (control group (CG)= 4 (2 and test group (TG)= 6) with primary endodontic infections, from both genders, between 17 and 65 years old, were analyzed. Microbiological samples were collected before and after chemical-mechanical instrumentation (CMI), after aPDT (for the TG), and after the removal of the temporary restorations (second session). In TG, the aPDT was performed with 100 μg/mL methylene blue and irradiated with low power laser (InGaAIP, 660 nm; 100 mW; 40 sec) with a fiber-coupled optical laser...
November 22, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29166439/the-geographic-information-system-applied-to-study-schistosomiasis-in-pernambuco
#3
Verônica Santos Barbosa, Rodrigo Moraes Loyo, Ricardo José de Paula Souza E Guimarães, Constança Simões Barbosa
OBJECTIVE: Diagnose risk environments for schistosomiasis in coastal localities of Pernambuco using geoprocessing techniques. METHODS: A coproscopic and malacological survey were carried out in the Forte Orange and Serrambi areas. Environmental variables (temperature, salinity, pH, total dissolved solids and water fecal coliform dosage) were collected from Biomphalaria breeding sites or foci. The spatial analysis was performed using ArcGis 10.1 software, applying the kernel estimator, elevation map, and distance map...
2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29166392/intestinal-ralstonia-pickettii-augments-glucose-intolerance-in-obesity
#4
Shanthadevi D Udayappan, Petia Kovatcheva-Datchary, Guido J Bakker, Stefan R Havik, Hilde Herrema, Patrice D Cani, Kristien E Bouter, Clara Belzer, Julia J Witjes, Anne Vrieze, Noor de Sonnaville, Alice Chaplin, Daniel H van Raalte, Steven Aalvink, Geesje M Dallinga-Thie, Hans G H J Heilig, Göran Bergström, Suzan van der Meij, Bart A van Wagensveld, Joost B L Hoekstra, Frits Holleman, Erik S G Stroes, Albert K Groen, Fredrik Bäckhed, Willem M de Vos, Max Nieuwdorp
An altered intestinal microbiota composition has been implicated in the pathogenesis of metabolic disease including obesity and type 2 diabetes mellitus (T2DM). Low grade inflammation, potentially initiated by the intestinal microbiota, has been suggested to be a driving force in the development of insulin resistance in obesity. Here, we report that bacterial DNA is present in mesenteric adipose tissue of obese but otherwise healthy human subjects. Pyrosequencing of bacterial 16S rRNA genes revealed that DNA from the Gram-negative species Ralstonia was most prevalent...
2017: PloS One
https://www.readbyqxmd.com/read/29166047/ortho-para-interconversion-in-cation-water-complexes-the-case-of-v-h2o-and-nb-h2o-clusters
#5
T B Ward, E Miliordos, P D Carnegie, S S Xantheas, M A Duncan
Vanadium and niobium cation-water complexes, V(+)(H2O) and Nb(+)(H2O), are produced by laser vaporization in a pulsed supersonic expansion, mass selected in a time-of-flight spectrometer, and studied with infrared photodissociation spectroscopy using rare gas atom (Ar, Ne) complex predissociation. The vibrational bands measured in the O-H stretching region contain K-type rotational sub-band structure, which provides insight into the structures of these complexes. However, rotational sub-bands do not exhibit the simple patterns seen previously for other metal ion-water complexes...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29165796/international-bullous-diseases-group-consensus-on-diagnostic-criteria-for-epidermolysis-bullosa-acquisita
#6
REVIEW
C Prost-Squarcioni, F Caux, E Schmidt, M F Jonkman, S Vassileva, S C Kim, P Iranzo, M Daneshpazhooh, J Terra, J Bauer, J Fairley, R Hall, M Hertl, J S Lehman, B Marinovic, A Patsatsi, D Zillikens, V Werth, D T Woodley, D F Murrell
BACKGROUND: Epidermolysis bullosa acquisita (EBA) is a complex autoimmune bullous disease disease with variable clinical presentations and multiple possible diagnostic tests making an international consensus on diagnosis of EBA needed. OBJECTIVES: To obtain an international consensus on the clinical and diagnostic criteria for EBA. METHODS: The international bullous diseases group (IBDG) met three times to discuss the clinical and diagnostic criteria for EBA...
November 22, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29165662/increased-global-dna-hypomethylation-in-distant-metastatic-and-dedifferentiated-thyroid-cancer
#7
E N Klein Hesselink, Carles Zafon, Núria Villalmanzo, Carmela Iglesias, B M van Hemel, M S Klein Hesselink, Cristina Montero-Conde, Raquel Buj, Dídac Mauricio, Miguel A Peinado, Manel Puig-Domingo, Garcilaso Riesco-Eizaguirre, Jordi L Reverter, Mercedes Robledo, T P Links, Mireia Jordà
Introduction: Global DNA hypomethylation is a major event for the development and progression of cancer, although the significance in thyroid cancer remains unclear. Therefore, we aimed to investigate its role in thyroid cancer progression and its potential as a prognostic marker. Methods: Global hypomethylation of Alu repeats was used as a surrogate marker for DNA global hypomethylation, and was assessed using the Quantification of Unmethylated Alu (QUAlu) technique...
November 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29165439/proteomic-signatures-differentiating-bacillus-anthracis-sterne-sporulation-on-soil-relative-to-laboratory-media
#8
D S Wunschel, J R Hutchison, B L Deatherage Kaiser, E D Merkley, B M Hess, A Lin, M G Warner
The process of sporulation is vital for the stability and infectious cycle of Bacillus anthracis. The spore is the infectious form of the organism and therefore relevant to biodefense. While the morphological and molecular events occurring during sporulation have been well studied, the influence of growth medium and temperature on the proteins expressed in sporulated cultures is not well understood. Understanding the features of B. anthracis sporulation specific to natural vs. laboratory production will address an important question in microbial forensics...
November 22, 2017: Analyst
https://www.readbyqxmd.com/read/29165423/meeting-report-a-hard-look-at-the-state-of-enamel-research
#9
REVIEW
Ophir D Klein, Olivier Duverger, Wendy Shaw, Rodrigo S Lacruz, Derk Joester, Janet Moradian-Oldak, Megan K Pugach, J Timothy Wright, Sarah E Millar, Ashok B Kulkarni, John D Bartlett, Thomas Gh Diekwisch, Pamela DenBesten, James P Simmer
The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines (ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research (NIDCR). Discussion topics included model organisms, stem cells/cell lines, and tissues/3D cell culture/organoids. Scientists from a number of disciplines, representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field...
November 22, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/29164810/anionic-redox-chemistry-in-polysulfide-electrode-materials-for-rechargeable-batteries
#10
Ekaterina D Grayfer, Egor M Pazhetnov, Mariia N Kozlova, Sofya B Artemkina, Vladimir E Fedorov
Classical Li-ion battery technology is based on the insertion of lithium ions into cathode materials involving metal (cationic) redox reactions. However, this vision is now being reconsidered, as many new-generation electrode materials with enhanced reversible capacities operate through combined cationic and anionic (non-metal) reversible redox processes or even exclusively through anionic redox transformations. Anionic participation in the redox reactions is observed in materials with more pronounced covalency, which is less typical for oxides, but quite common for phosphides or chalcogenides...
November 22, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29164765/maternal-pre-pregnancy-obesity-and-child-neurodevelopmental-outcomes-a-meta-analysis
#11
REVIEW
C E Sanchez, C Barry, A Sabhlok, K Russell, A Majors, S H Kollins, B F Fuemmeler
This review examined evidence of the association between maternal pre-pregnancy overweight/obesity status and child neurodevelopmental outcomes. PubMed and PsycINFO databases were systematically searched for empirical studies published before April 2017 using keywords related to prenatal obesity and children's neurodevelopment. Of 1483 identified papers, 41 were included in the systematic review, and 32 articles representing 36 cohorts were included in the meta-analysis. Findings indicated that compared with children of normal weight mothers, children whose mothers were overweight or obese prior to pregnancy were at increased risk for compromised neurodevelopmental outcomes (overweight: OR = 1...
November 22, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29164497/identifying-motives-of-midlife-black-triathlete-women-using-survey-transformation-to-guide-qualitative-inquiry
#12
Candace S Brown, Kevin S Masters, Amy G Huebschmann
Demonstrating health disparities related to race, age, and gender, older Black women (BW) are the most sedentary demographic group in the United States. Increasing PA in mid-life is important, as it improves health as BW age into their later years. Advancing our understanding of the exercise motives of BW triathletes presents a "reverse engineering" opportunity to identify motives that could influence sedentary mid-life BW to increase their activity. The purposes of this study were to: (a) utilize an innovative survey transformation method to adapt a measure developed primarily in Caucasian males, i...
November 22, 2017: Journal of Cross-cultural Gerontology
https://www.readbyqxmd.com/read/29164414/a-novel-t-stage-classification-system-for-adrenocortical-carcinoma-proposal-from-the-us-adrenocortical-carcinoma-study-group
#13
Caroline E Poorman, Cecilia G Ethun, Lauren M Postlewait, Thuy B Tran, Jason D Prescott, Timothy M Pawlik, Tracy S Wang, Jason Glenn, Ioannis Hatzaras, Rivfka Shenoy, John E Phay, Kara Keplinger, Ryan C Fields, Linda X Jin, Sharon M Weber, Ahmed Salem, Jason K Sicklick, Shady Gad, Adam C Yopp, John C Mansour, Quan-Yang Duh, Natalie Seiser, Carmen C Solórzano, Colleen M Kiernan, Konstantinos I Votanopoulos, Edward A Levine, Charles A Staley, George A Poultsides, Shishir K Maithel
BACKGROUND: The 7th AJCC T-stage system for adrenocortical carcinoma (ACC), based on size and extra-adrenal invasion, does not adequately stratify patients by survival. Lymphovascular invasion (LVI) is a known poor prognostic factor. We propose a novel T-stage system that incorporates LVI to better risk-stratify patients undergoing resection for ACC. METHOD: Patients undergoing curative-intent resections for ACC from 1993 to 2014 at 13 institutions comprising the US ACC Group were included...
November 21, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29164332/individual-trajectories-of-cognitive-performance-in-first-episode-psychosis-a-2-year-follow-up-study
#14
A M Sánchez-Torres, L Moreno-Izco, R Lorente-Omeñaca, B Cabrera, A Lobo, A M González-Pinto, J Merchán-Naranjo, I Corripio, E Vieta, E de la Serna, A Butjosa, F Contreras, S Sarró, G Mezquida, M Ribeiro, M Bernardo, M J Cuesta
Individual changes over time in cognition in patients with psychotic disorders have been studied very little, especially in the case of first episode psychosis (FEP). We aimed to establish whether change in individual trajectories in cognition over 2 years of a sample of 159 FEP patients was reliable and clinically significant, using the reliable change index (RCI) and clinically significant change (CSC) methods. We also studied a sample of 151 matched healthy controls. Patients and controls were assessed with a set of neuropsychological tests, as well as premorbid, clinical and functionality measures...
November 21, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29164177/a-systems-medicine-approach-translating-emerging-science-into-individualized-wellness
#15
REVIEW
J S Bland, D M Minich, B M Eck
In today's aging society, more people are living with lifestyle-related noncommunicable diseases (NCDs) such as cardiovascular disease, type 2 diabetes, obesity, and cancer. Numerous opinion-leader organizations recommend lifestyle medicine as the first-line approach in NCD prevention and treatment. However, there is a strong need for a personalized approach as "one-size-fits-all" public health recommendations have been insufficient in addressing the interindividual differences in the diverse populations. Advancement in systems biology and the "omics" technologies has allowed comprehensive analysis of how complex biological systems are impacted upon external perturbations (e...
2017: Advances in Medicine
https://www.readbyqxmd.com/read/29164135/a-protocol-for-improved-precision-and-increased-confidence-in-nanoparticle-tracking-analysis-concentration-measurements-between-50-and-120%C3%A2-nm-in-biological-fluids
#16
Martin E M Parsons, Damien McParland, Paulina B Szklanna, Matthew Ho Zhi Guang, Karen O'Connell, Hugh D O'Connor, Christopher McGuigan, Fionnuala Ní Áinle, Amanda McCann, Patricia B Maguire
Nanoparticle tracking analysis (NTA) can be used to quantitate extracellular vesicles (EVs) in biological samples and is widely considered a useful diagnostic tool to detect disease. However, accurately profiling EVs can be challenging due to their small size and heterogeneity. Here, we aimed to provide a protocol to facilitate high-precision particle quantitation by NTA in plasma, the supernatant of activated purified platelets [the platelet releasate (PR)] and in serum, to increase confidence in NTA particle enumeration...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29164071/galectin-3-a-friend-but-not-a-foe-during-trypanosoma-cruzi-experimental-infection
#17
Aline A da Silva, Thaise L Teixeira, Samuel C Teixeira, Fabrício C Machado, Marlus A Dos Santos, Tatiana C Tomiosso, Paula C B Tavares, Rebecca T E Silva Brígido, Flávia Alves Martins, Nadjania S de Lira Silva, Cassiano C Rodrigues, Maria C Roque-Barreira, Renato A Mortara, Daiana S Lopes, Veridiana de Melo Rodrigues Ávila, Claudio V da Silva
Trypanosoma cruzi interacts with host cells, including cardiomyocytes, and induces the production of cytokines, chemokines, metalloproteinases, and glycan-binding proteins. Among the glycan-binding proteins is Galectin-3 (Gal-3), which is upregulated after T. cruzi infection. Gal-3 is a member of the lectin family with affinity for β-galactose containing molecules; it can be found in both the nucleus and the cytoplasm and can be either membrane-associated or secreted. This lectin is involved in several immunoregulatory and parasite infection process...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29164038/timing-of-decompression-in-patients-with-acute-spinal-cord-injury-a-systematic-review
#18
REVIEW
Jefferson R Wilson, Lindsay A Tetreault, Brian K Kwon, Paul M Arnold, Thomas E Mroz, Christopher Shaffrey, James S Harrop, Jens R Chapman, Steve Casha, Andrea C Skelly, Haley K Holmer, Erika D Brodt, Michael G Fehlings
Study Design: Systematic review. Objective: To conduct a systematic review and synthesis of the literature to assess the comparative effectiveness, safety, and cost-effectiveness of early (≤24 hours) versus late decompression (>24 hours) in adults with acute spinal cord injury (SCI). Methods: A systematic search was conducted of Medline, EMBASE, the Cochrane Collaboration Library, and Google Scholar to identify studies published through November 6, 2014...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29163915/field-deployable-quantitative-rapid-identification-of-active-ebola-virus-infection-in-unprocessed-blood
#19
Kavit Shah, Emma Bentley, Adam Tyler, Kevin S R Richards, Edward Wright, Linda Easterbrook, Diane Lee, Claire Cleaver, Louise Usher, Jane E Burton, James K Pitman, Christine B Bruce, David Edge, Martin Lee, Nelson Nazareth, David A Norwood, Sterghios A Moschos
The West African Ebola virus outbreak underlined the importance of delivering mass diagnostic capability outside the clinical or primary care setting in effectively containing public health emergencies caused by infectious disease. Yet, to date, there is no solution for reliably deploying at the point of need the gold standard diagnostic method, real time quantitative reverse transcription polymerase chain reaction (RT-qPCR), in a laboratory infrastructure-free manner. In this proof of principle work, we demonstrate direct performance of RT-qPCR on fresh blood using far-red fluorophores to resolve fluorogenic signal inhibition and controlled, rapid freeze/thawing to achieve viral genome extraction in a single reaction chamber assay...
November 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29163891/identification-of-new-quorum-sensing-autoinducer-binding-partners-in-pseudomonas-aeruginosa-using-photoaffinity-probes
#20
Y R Baker, J T Hodgkinson, B I Florea, E Alza, W R J D Galloway, L Grimm, S M Geddis, H S Overkleeft, M Welch, D R Spring
Many bacterial species, including the human pathogen Pseudomonas aeruginosa, employ a mechanism of intercellular communication known as quorum sensing (QS), which is mediated by signalling molecules termed autoinducers. The Pseudomonas Quinolone Signal (PQS) and 2-Heptyl-3H-4-Quinolone (HHQ) are autoinducers in P. aeruginosa, and they are considered important factors in the progress of infections by this clinically relevant organism. Herein, we report the development of HHQ and PQS photoaffinity-based probes for chemical proteomic studies...
November 1, 2017: Chemical Science
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