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https://www.readbyqxmd.com/read/27895847/efficacy-of-a-low-cost-bubble-cpap-system-in-treatment-of-respiratory-distress-in-a-neonatal-ward-in-malawi
#1
Kondwani Kawaza, Heather E Machen, Jocelyn Brown, Zondiwe Mwanza, Suzanne Iniguez, Al Gest, E O'Brian Smith, Maria Oden, Rebecca R Richards-Kortum, Elizabeth Molyneux
BACKGROUND: Respiratory failure is a leading cause of neonatal mortality in the developing world. Bubble continuous positive airway pressure (bCPAP) is a safe, effective intervention for infants with respiratory distress and is widely used in developed countries. Because of its high cost, bCPAP is not widely utilized in low-resource settings. We evaluated the performance of a new bCPAP system to treat severe respiratory distress in a low resource setting, comparing it to nasal oxygen therapy, the current standard of care...
September 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/27790540/a-randomized-trial-comparing-efficacy-of-bubble-and-ventilator-derived-nasal-cpap-in-very-low-birth-weight-neonates-with-respiratory-distress
#2
Sheetal Agarwal, Arti Maria, Mahesh K Roy, Ankit Verma
INTRODUCTION: Continuous Positive Airway Pressure (CPAP) has an established role in the care of Very Low Birth Weight (VLBW) babies with respiratory distress. Bubble CPAP (BCPAP) is a cheap alternative for countries where resources are limited. However, data comparing efficacy of BCPAP with conventional ventilator derived (VCPAP) is limited. AIM: To compare CPAP failure rates between BCPAP and VCPAP among VLBW, with moderate respiratory distress. Secondary objectives were to compare the rates of Intraventricular Haemorrhage (IVH), pulmonary air leaks and deaths between the two groups and determine the predictors of CPAP failure...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27711045/non-invasive-inhaled-nitric-oxide-in-the-treatment-of-hypoxemic-respiratory-failure-in-term-and-preterm-infants
#3
R Sahni, X Ameer, K Ohira-Kist, J-T Wung
OBJECTIVES: Inhaled nitric oxide (iNO) is effective in conjunction with tracheal intubation (TI) and mechanical ventilation (MV) for treating arterial pulmonary hypertension and hypoxemic respiratory failure (HRF) in near-term and term newborns. Non-invasive respiratory support with nasal continuous positive airway pressure (CPAP) is increasingly used to avoid morbidity associated with TI and MV, yet the effectiveness of iNO delivery via nasal CPAP remains unknown. To evaluate the effectiveness of iNO delivered via the bubble nasal CPAP system in term and preterm newborns with HRF...
October 6, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27194606/early-bubble-continuous-positive-airway-pressure-investigating-interprofessional-best-practices-for-the-nicu-team
#4
Jessica L Casey, Desi Newberry, Amy Jnah
Premature neonates delivered <32 completed weeks gestation are unprepared to handle the physiologic demands of extrauterine life. Within the respiratory system, alveolar instability and collapse can cause decreased functional residual capacity, impaired oxygenation, and hypoxemia leading to respiratory distress syndrome. Supportive measures are indicated immediately after birth to establish physiologic stability including bubble continuous positive airway pressure (CPAP) or endotracheal intubation and mechanical ventilation...
2016: Neonatal Network: NN
https://www.readbyqxmd.com/read/27118822/effect-of-treatment-of-premature-infants-with-respiratory-distress-using-low-cost-bubble-cpap-in-a-rural-african-hospital
#5
Jennifer Myhre, Mutisya Immaculate, Bob Okeyo, Matthew Anand, Anastacia Omoding, Luke Myhre, Lilian Okeyo, Immaculate Barasa, Steve Letchford
BACKGROUND: Kenya's neonatal mortality rate remains unacceptably high, at 22 deaths per 1000 live births, with a third of those attributable to prematurity. Respiratory distress syndrome (RDS) is the single most important cause of morbidity and mortality in the premature neonate. Continuous positive airway pressure (CPAP) is a proven modality of therapy but is rarely used in low-resource settings. We report on the introduction of bubble CPAP (BCPAP), a low-cost method of delivering CPAP appropriate to our setting, by comparing survival-to-discharge before and after the technology was introduced...
October 2016: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/27109089/efficacy-and-safety-of-cpap-in-low-and-middle-income-countries
#6
A Thukral, M J Sankar, A Chandrasekaran, R Agarwal, V K Paul
We conducted a systematic review to evaluate the (1) feasibility and efficacy and (2) safety and cost effectiveness of continuous positive airway pressure (CPAP) therapy in low- and middle-income countries (LMIC). We searched the following electronic bibliographic databases-MEDLINE, Cochrane CENTRAL, CINAHL, EMBASE and WHOLIS-up to December 2014 and included all studies that enrolled neonates requiring CPAP therapy for any indication. We did not find any randomized trials from LMICs that have evaluated the efficacy of CPAP therapy...
May 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/26955624/analysis-and-comparison-of-the-effects-of-n-bipap-and-bubble-cpap-in-treatment-of-preterm-newborns-with-the-weight-of-below-1500-grams-affiliated-with-respiratory-distress-syndrome-a-randomised-clinical-trial
#7
Alireza Sadeghnia, Behzad Barekateyn, Zohre Badiei, Seyyed Mohsen Hosseini
BACKGROUND: Nowadays, establishment of nCPAP and surfactant administration is considered to be the first level of intervention for newborns engaged in the process of Respiratory Distress Syndrome (RDS). In order to decrease the side effects of the nCPAP management placed in noninvasive-non-cycled respiratory support. Noninvasive-cycled respiratory support mechanism have been developed such as N-BiPAP. Therefore, we compared N-BiPAP with Bubble-CPAP in a clinical trial. MATERIALS AND METHODS: This research was done as an on newborns weighing less than 1500 grams affiliated with RDS...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/26936186/strategies-for-the-prevention-of-continuous-positive-airway-pressure-failure
#8
REVIEW
Rakesh Sahni, Maria Schiaratura, Richard A Polin
Progress in neonatal intensive care is closely linked to improvements in the management of respiratory failure in preterm infants. Current modalities of respiratory support range from the more benign continuous positive airway pressure (CPAP) to various modes of mechanical ventilation. Data from recent randomized control trials suggest that the use of nasal (n)CPAP as the initial mode of respiratory support in critically ill very low birth weight infants is associated with a lower incidence of chronic lung disease...
June 2016: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26936093/initiating-nasal-continuous-positive-airway-pressure-in-preterm-neonates-at-5-cm-as-against-7-cm-did-not-decrease-the-need-for-mechanical-ventilation
#9
Srinivas Murki, Prem Prakash Nathani, Deepak Sharma, Sreeram Subramaniam, Tejo Pratap Oleti, Deepak Chawla
AIM: The optimum starting nasal continuous positive airway pressure (nCPAP) for infants on bubble nCPAP is unknown. We compared whether an initial bubble nCPAP of 7 cm rather than 5 cm of water prevented the need for mechanical ventilation among preterm neonates with respiratory distress. METHODS: Preterm neonates born at 27-34 weeks with the onset of respiratory distress within 24 hours of birth were randomised to receive high or standard nCPAP at either 7 cm or 5 cm of water, respectively...
August 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/26915655/non-invasive-respiratory-support-for-infants-in-low-and-middle-income-countries
#10
Erik A Jensen, Aasma Chaudhary, Zulfiqar A Bhutta, Haresh Kirpalani
The overwhelming majority of neonatal deaths worldwide occur in low- and middle-income countries. Most of these deaths are attributable to respiratory illnesses and complications of preterm birth. The available data suggest that non-invasive continuous positive airway pressure (CPAP) is a safe and cost-effective therapy to reduce neonatal morbidity and mortality in these settings. Bubble CPAP compared to mechanical ventilator-generated CPAP reduces the need for subsequent invasive ventilation in newborn infants...
June 2016: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26800273/bubble-cpap-support-after-discontinuation-of-mechanical-ventilation-protects-rat-lungs-with-ventilator-induced-lung-injury
#11
Chun Shan Wu, Hsiu Chu Chou, Liang Ti Huang, Yen Kuang Lin, Chung Ming Chen
BACKGROUND: Bubble continuous positive airway pressure (BCPAP) has been used in neonates with respiratory distress for decades, but its lung-protective effect and underlying mechanism has not been investigated. OBJECTIVES: To test the hypothesis that BCPAP use after extubation decreases lung injury and that alterations to lung nitric oxide synthase (NOS) 3 expression may be one of the underlying mechanisms. METHODS: We compared gas exchange, lung injury severity, and lung NOS expression among rats with ventilator-induced lung injury (VILI) treated with either BCPAP or spontaneous breathing...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/26534997/evaluating-the-effect-of-flow-and-interface-type-on-pressures-delivered-with-bubble-cpap-in-a-simulated-model
#12
Stephanie A Bailes, Kimberly S Firestone, Diane K Dunn, Neil L McNinch, Miraides F Brown, Teresa A Volsko
BACKGROUND: Bubble CPAP, used for spontaneously breathing infants to avoid intubation or postextubation support, can be delivered with different interface types. This study compared the effect that interfaces had on CPAP delivery. We hypothesized that there would be no difference between set and measured levels between interface types. METHODS: A validated preterm infant nasal airway model was attached to the ASL 5000 breathing simulator. The simulator was programmed to deliver active breathing of a surfactant-deficient premature infant with breathing frequency at 70 breaths/min inspiratory time of 0...
March 2016: Respiratory Care
https://www.readbyqxmd.com/read/26528456/a-fixed-flow-is-more-effective-than-titrated-flow-during-bubble-nasal-cpap-for-respiratory-distress-in-preterm-neonates
#13
Srinivas Murki, Ratan Kumar Das, Deepak Sharma, Praveen Kumar
BACKGROUND: The clinical effects of a pre-fixed flow of air-oxygen versus a flow titrated according to visible bubbling are not well understood. OBJECTIVE: To compare the effects of a fixed flow (5 L/min) and titrated flow (flow just enough to ensure bubbling) at different set pressures on delivered intra-prong pressure, gas exchange and clinical parameters in preterm infants on bubble CPAP for respiratory distress. METHODS: Preterm infants <35 weeks gestational age on bubble CPAP and <96 h of age were enrolled in this crossover study...
2015: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/26428195/use-of-nasal-bubble-cpap-in-children-with-hypoxemic-clinical-pneumonia-report-from-a-resource-limited-set-up
#14
Muralidharan Jayashree, H B KiranBabu, Sunit Singhi, Karthi Nallasamy
OBJECTIVE: Nasal bubble continuous positive airway pressure (bCPAP) is preferred in developing economies for easy applicability and low cost. Because its use in older children is unexplored, we sought to evaluate its utility in hypoxemic clinical pneumonia. METHODS: Of 330 children (1 month-12 years) with clinical pneumonia enrolled prospectively over 1 year, those with increased work of breathing and/or SpO2 <92% received bCPAP delivered via an underwater 'T' tube through nasal prongs...
February 2016: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/26403679/bubble-cpap-to-support-preterm-infants-in-rural-rwanda-a-retrospective-cohort-study
#15
MULTICENTER STUDY
Evrard Nahimana, Masudi Ngendahayo, Hema Magge, Jackline Odhiambo, Cheryl L Amoroso, Ernest Muhirwa, Jean Nepo Uwilingiyemungu, Fulgence Nkikabahizi, Regis Habimana, Bethany L Hedt-Gauthier
BACKGROUND: Complications from premature birth contribute to 35% of neonatal deaths globally; therefore, efforts to improve clinical outcomes of preterm (PT) infants are imperative. Bubble continuous positive airway pressure (bCPAP) is a low-cost, effective way to improve the respiratory status of preterm and very low birth weight (VLBW) infants. However, bCPAP remains largely inaccessible in resource-limited settings, and information on the scale-up of this technology in rural health facilities is limited...
2015: BMC Pediatrics
https://www.readbyqxmd.com/read/26361989/outcomes-of-patients-with-respiratory-distress-treated-with-bubble-cpap-on-a-pediatric-ward-in-malawi
#16
COMPARATIVE STUDY
Heather E Machen, Zondiwe V Mwanza, Jocelyn K Brown, Kondwani M Kawaza, Laura Newberry, Rebecca R Richards-Kortum, Z Maria Oden, Elizabeth M Molyneux
OBJECTIVE: To describe the outcomes of infants and young children with respiratory distress when treated with a novel, low-cost, stand-alone bubble Continuous Positive Airway Pressure (bCPAP) system in a resource-limited setting. METHODS: A non-randomized, convenience sample study in a pediatric unit in Blantyre, Malawi, 2013. Patients weighing ≤10 kg with respiratory distress were eligible. We compared outcomes for patients with bronchiolitis, pneumonia and Pneumocystis jiroveci pneumonia (PJP) after treatment with bCPAP...
December 2015: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/26354368/the-effects-of-non-invasive-respiratory-support-on-oropharyngeal-temperature-and-humidity-a-neonatal-manikin-study
#17
Calum T Roberts, Rebecca Kortekaas, Jennifer A Dawson, Brett J Manley, Louise S Owen, Peter G Davis
OBJECTIVE: Heating and humidification of inspired gases is routine during neonatal non-invasive respiratory support. However, little is known about the temperature and humidity delivered to the upper airway. The International Standards Organization (ISO) specifies that for all patients with an artificial airway humidifiers should deliver ≥33 g/m(3) absolute humidity (AH). We assessed the oropharyngeal temperature and humidity during different non-invasive support modes in a neonatal manikin study...
May 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/26352079/randomized-control-trial-comparing-physiologic-effects-in-preterm-infants-during-treatment-with-nasal-continuous-positive-airway-pressure-ncpap-generated-by-bubble-ncpap-and-ventilator-ncpap-a-pilot-study
#18
Craig Guerin, Sean M Bailey, Pradeep V Mally, Mary Rojas, Alok Bhutada, Shantanu Rastogi
OBJECTIVES: Nasal continuous positive airway pressure (NCPAP) is an accepted form of non-invasive ventilation in preterm infants. Few, if any, studies have shown an advantage of one type of NCPAP over another. It has been theorized that bubble-generated NCPAP may be advantageous for the preterm neonate versus traditionally used ventilator-generated NCPAP. The aim of this study was to examine for any short-term differences in physiologic parameters in preterm subjects receiving these two different methods of NCPAP...
August 1, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/26311458/bubble-cpap-for-pneumonia-perils-of-stopping-trials-early
#19
COMMENT
Frank Shann, Theis Lange
No abstract text is available yet for this article.
September 12, 2015: Lancet
https://www.readbyqxmd.com/read/26296950/bubble-continuous-positive-airway-pressure-for-children-with-severe-pneumonia-and-hypoxaemia-in-bangladesh-an-open-randomised-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
Mohammod J Chisti, Mohammed A Salam, Jonathan H Smith, Tahmeed Ahmed, Mark A C Pietroni, K M Shahunja, Abu S M S B Shahid, Abu S G Faruque, Hasan Ashraf, Pradip K Bardhan, Sharifuzzaman, Stephen M Graham, Trevor Duke
BACKGROUND: In developing countries, mortality in children with very severe pneumonia is high, even with the provision of appropriate antibiotics, standard oxygen therapy, and other supportive care. We assessed whether oxygen therapy delivered by bubble continuous positive airway pressure (CPAP) improved outcomes compared with standard low-flow and high-flow oxygen therapies. METHODS: This open, randomised, controlled trial took place in Dhaka Hospital of the International Centre for Diarrhoeal Disease Research, Bangladesh...
September 12, 2015: Lancet
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