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https://www.readbyqxmd.com/read/28917688/a-randomized-trial-of-pocket-echocardiography-integrated-mobile-health-device-assessments-in-modern-structural-heart-disease-clinics
#1
Sanjeev P Bhavnani, Srikanth Sola, David Adams, Ashwin Venkateshvaran, P K Dash, Partho P Sengupta
OBJECTIVES: This study sought to determine whether mobile health (mHealth) device assessments used as clinical decision support tools at the point-of-care can reduce the time to treatment and improve long-term outcomes among patients with rheumatic and structural heart diseases (SHD). BACKGROUND: Newly developed smartphone-connected mHealth devices represent promising methods to diagnose common diseases in resource-limited areas; however, the impact of technology-based care on long-term outcomes has not been rigorously evaluated...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28916508/development-of-a-whole-slide-imaging-system-on-smartphones-and-evaluation-with-frozen-section-samples
#2
Hong Yu, Feng Gao, Liren Jiang, Shuoxin Ma
BACKGROUND: The aim was to develop scalable Whole Slide Imaging (sWSI), a WSI system based on mainstream smartphones coupled with regular optical microscopes. This ultra-low-cost solution should offer diagnostic-ready imaging quality on par with standalone scanners, supporting both oil and dry objective lenses of different magnifications, and reasonably high throughput. These performance metrics should be evaluated by expert pathologists and match those of high-end scanners. OBJECTIVE: The aim was to develop scalable Whole Slide Imaging (sWSI), a whole slide imaging system based on smartphones coupled with optical microscopes...
September 15, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28915827/evaluating-the-impact-of-a-walking-program-in-a-disadvantaged-area-using-the-re-aim-framework-by-mixed-methods
#3
Camila Tiome Baba, Isabela Martins Oliveira, Adriele Evelyn Ferreira Silva, Leonardo Moreira Vieira, Natalia Caroline Cerri, Alex Antonio Florindo, Grace Angélica de Oliveira Gomes
BACKGROUND: The positive health impact of physical activity (PA) is well known, yet a large proportion of the world's population remains sedentary. General PA programs are common as health promotion initiatives. However, effectiveness evaluations of such PA programs on individual and organizational aspects, which could inform the decision-making process of public health bodies are still lacking, particularly in the most socially disadvantaged areas, where health promotion schemes are particularly needed...
September 15, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28915796/correlates-of-isoniazid-preventive-therapy-failure-in-child-household-contacts-with-infectious-tuberculosis-in-high-burden-settings-in-nairobi-kenya-a-cohort-study
#4
Florence Nafula Okwara, John Paul Oyore, Fred Nabwire Were, Samson Gwer
BACKGROUND: Sub-Saharan Africa continues to document high pediatric tuberculosis (TB) burden, especially among the urban poor. One recommended preventive strategy involves tracking and isoniazid preventive therapy (IPT) for children under 5 years in close contact with infectious TB. However, sub-optimal effectiveness has been documented in diverse settings. We conducted a study to elucidate correlates to IPT strategy failure in children below 5 years in high burden settings. METHODS: A prospective longitudinal cohort study was done in informal settlings in Nairobi, where children under 5 years in household contact with recently diagnosed smear positive TB adults were enrolled...
September 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28914185/power-potential-and-pitfalls-in-global-health-academic-partnerships-review-and-reflections-on-an-approach-in-nepal
#5
David Citrin, Stephen Mehanni, Bibhav Acharya, Lena Wong, Isha Nirola, Rekha Sherchan, Bikash Gauchan, Khem Bahadur Karki, Dipendra Raman Singh, Sriram Shamasunder, Phuoc Le, Dan Schwarz, Ryan Schwarz, Binod Dangal, Santosh Kumar Dhungana, Sheela Maru, Ramesh Mahar, Poshan Thapa, Anant Raut, Mukesh Adhikari, Indira Basnett, Shankar Prasad Kaluanee, Grace Deukmedjian, Scott Halliday, Duncan Maru
BACKGROUND: Global health academic partnerships are centered around a core tension: they often mirror or reproduce the very cross-national inequities they seek to alleviate. On the one hand, they risk worsening power dynamics that perpetuate health disparities; on the other, they form an essential response to the need for healthcare resources to reach marginalized populations across the globe. OBJECTIVES: This study characterizes the broader landscape of global health academic partnerships, including challenges to developing ethical, equitable, and sustainable models...
2017: Global Health Action
https://www.readbyqxmd.com/read/28913544/what-s-new-in-picu-in-resource-limited-settings
#6
Andrew C Argent, Mohammod J Chisti, Suchitra Ranjit
No abstract text is available yet for this article.
September 14, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28906580/comparison-of-one-commercial-and-two-in-house-taqman-multiplex-real-time-pcr-assays-for-detection-of-enteropathogenic-enterotoxigenic-and-enteroaggregative-escherichia-coli
#7
Andreas Hahn, Marc Luetgehetmann, Olfert Landt, Norbert Georg Schwarz, Hagen Frickmann
OBJECTIVE: Enteropathogenic, enterotoxigenic, and enteroaggregative Escherichia coli (EPEC, ETEC, EAEC) are among the most frequent causes of diarrhea during travel or on military deployments. Cost efficient and reliable real-time multiplex PCR (mPCR) assays are desirable for surveillance or point prevalence studies in remote and resource-limited tropical settings. We compared one commercial PCR kit and two in-house assays without using a gold standard to estimate sensitivity and specificity of each assay...
September 14, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28906530/the-effect-of-lifestyle-interventions-on-maternal-body-composition-during-pregnancy-in-developing-countries-a-systematic-review
#8
REVIEW
Estelle D Watson, Shelley Macaulay, Kim Lamont, Philippe J-L Gradidge, Sandra Pretorius, Nigel J Crowther, Elena Libhaber
Optimal maternal body composition during pregnancy is a public health priority due to its implications on maternal health and infant development. We therefore aimed to conduct a systematic review of randomised, controlled trials, and case-control and cohort studies using lifestyle interventions to improve body composition in developing countries. Of the 1 708 articles that were searched, seven studies, representing three countries (Brazil, Iran and Argentina), were included in the review. Two articles suggested that intervention with physical activity during pregnancy may significantly reduce maternal weight gain, and five studies were scored as being of poor quality...
August 24, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28906279/the-value-of-point-of-care-cd4-and-laboratory-viral-load-in-tailoring-antiretroviral-therapy-monitoring-strategies-to-resource-limitations
#9
Emily P Hyle, Ilesh V Jani, Katherine L Rosettie, Robin Wood, Benjamin Osher, Stephen Resch, Pamela P Pei, Paolo Maggiore, Kenneth A Freedberg, Trevor Peter, Robert A Parker, Rochelle P Walensky
OBJECTIVE: To examine the clinical and economic value of point-of-care CD4 (POC-CD4) or viral load monitoring compared with current practices in Mozambique, a country representative of the diverse resource limitations encountered by HIV treatment programs in sub-Saharan Africa. DESIGN/METHODS: We use the Cost-Effectiveness of Preventing AIDS Complications-International model to examine the clinical impact, cost (2014 US$), and incremental cost-effectiveness ratio [$/year of life saved (YLS)] of ART monitoring strategies in Mozambique...
September 24, 2017: AIDS
https://www.readbyqxmd.com/read/28903726/a-novel-diagnostic-method-for-malaria-using-loop-mediated-isothermal-amplification-lamp-and-minion%C3%A2-nanopore-sequencer
#10
Kazuo Imai, Norihito Tarumoto, Kazuhisa Misawa, Lucky Ronald Runtuwene, Jun Sakai, Kyoko Hayashida, Yuki Eshita, Ryuichiro Maeda, Josef Tuda, Takashi Murakami, Shigefumi Maesaki, Yutaka Suzuki, Junya Yamagishi, Takuya Maeda
BACKGROUND: A simple and accurate molecular diagnostic method for malaria is urgently needed due to the limitations of conventional microscopic examination. In this study, we demonstrate a new diagnostic procedure for human malaria using loop mediated isothermal amplification (LAMP) and the MinION™ nanopore sequencer. METHODS: We generated specific LAMP primers targeting the 18S-rRNA gene of all five human Plasmodium species including two P. ovale subspecies (P...
September 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28903628/what-motivates-serodiscordant-couples-to-prevent-hiv-transmission-within-their-relationships-findings-from-a-prep-implementation-study-in-kenya
#11
Rena C Patel, Anna M Leddy, Josephine Odoyo, Keerthana Anand, Gaelen Stanford-Moore, Imeldah Wakhungu, Elizabeth A Bukusi, Jared M Baeten, Joelle M Brown
With the planned scale-up of pre-exposure prophylaxis (PrEP) for HIV prevention among serodiscordant couples in resource-limited settings, gaining an understanding of what motivates serodiscordant couples to prevent HIV is critical. We conducted 44 semi-structured, in-depth individual or couple interviews with 63 participants (33 HIV-infected and 30 HIV-uninfected participants) enrolled in a prospective implementation study of oral antiretroviral-based prevention in Kisumu, Kenya. Transcripts were iteratively analysed using inductive content analysis...
September 14, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28903080/transplacental-transfer-of-maternal-respiratory-syncytial-virus-rsv-antibody-and-protection-against-rsv-disease-in-infants-in-rural-nepal
#12
Helen Y Chu, James Tielsch, Joanne Katz, Amalia S Magaret, Subarna Khatry, Stephen C LeClerq, Laxman Shrestha, Jane Kuypers, Mark C Steinhoff, Janet A Englund
BACKGROUND: Respiratory syncytial virus (RSV) is the most important viral cause of pneumonia in children. RSV-specific antibody (ab) protects infants from disease, and may be increased by a potential strategy of maternal RSV vaccination. OBJECTIVES: To describe the effect of RSV antibody on RSV infection risk in infants in a resource-limited setting. STUDY DESIGN: In a prospective study in Nepal, women were enrolled during pregnancy and maternal and infant cord blood were collected at birth...
September 2, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28902919/factors-associated-with-pulmonary-impairment-in-hiv-infected-south-african-adults
#13
Akshay N Gupte, Michelle L Wong, Reginah Msandiwa, Grace L Barnes, Jonathan Golub, Richard E Chaisson, Christopher J Hoffmann, Neil A Martinson
BACKGROUND: HIV-infected individuals have increased risk of developing obstructive lung disease (OLD). Studies from developed countries report high viral load, low CD4 counts, and anti-retroviral therapy (ART) to be associated with OLD; but these findings may not be generalizable to populations in resource-limited settings. METHODS: We conducted a prospective cohort study of lung function in 730 HIV-infected black South African adults. Pre-bronchodilator spirometry was performed at enrollment and repeated annually for three years...
2017: PloS One
https://www.readbyqxmd.com/read/28902680/multicountry-validation-of-samba-a-novel-molecular-point-of-care-test-for-hiv-1-detection-in-resource-limited-setting
#14
Johnson Ondiek, Zikulah Namukaya, Sekesai Mtapuri-Zinyowera, Suna Balkan, Ali Elbireer, Ines Ushiro Lumb, Charles Kiyaga, Neha Goel, Allyson Ritchie, Patience Ncube, Kenneth Omuomu, Kenneth Ndiege, Adeodata Kekitiinwa, Douglas Mangwanya, Mary G Fowler, Lou Nadala, Helen Lee
INTRODUCTION: Early diagnosis of HIV-1 infection and the prompt initiation of antiretroviral therapy are critical to achieving a reduction in the morbidity and mortality of infected infants. The Simple AMplification-Based Assay (SAMBA) HIV-1 Qual Whole Blood Test was developed specifically for early infant diagnosis and prevention of mother-to-child transmission programs implemented at the point-of-care in resource-limited settings. METHODS: We have evaluated the performance of this test run on the SAMBA I semiautomated platform with fresh whole blood specimens collected from 202 adults and 745 infants in Kenya, Uganda, and Zimbabwe...
October 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28902073/cryotherapy-reduces-progression-of-cervical-intraepithelial-neoplasia-grade-1-in-south-african-hiv-infected-women-a-randomized-controlled-trial
#15
Cynthia Firnhaber, Avril Swarts, Bridgette Goeieman, Ntombi Rakhombe, Masangu Mulongo, Anna-Lise Williamson, Pam Michelow, Sibongile Ramotshela, Mark Faesen, Simon Levin, Timothy Wilkin
BACKGROUND: HIV-infected women are at increased risk of cervical cancer, especially in resource-limited countries. Cervical cancer prevention strategies focus treating cervical high-grade squamous intraepithelial lesions (HSIL). The management of low-grade squamous intraepithelial lesions (LSIL) in HIV-infected women is unknown. SETTING: HIV treatment clinic in Johannesburg, South Africa METHODS:: We randomized HIV-infected women with histologic cervical LSIL to cervical cryotherapy vs...
September 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28901908/performance-of-point-of-care-xpert-hiv-1-plasma-viral-load-assay-at-a-tertiary-hiv-care-centre-in-southern-india
#16
Chinnambedu Ravichandran Swathirajan, Ramachandran Vignesh, Jayaseelan Boobalan, Sunil Suhas Solomon, Shanmugam Saravanan, Pachamuthu Balakrishnan
BACKGROUND: Sustainable suppression of HIV replication forms the basis of anti-retroviral therapy (ART) medication. Thus, reliable quantification of HIV viral load has become an essential factor to monitor the effectiveness of the ART. Longer turnaround-time (TAT), batch testing and technical skills are major drawbacks of standard real-time PCR assays. METHODS: The performance of the point-of-care Xpert HIV-1 viral load assay was evaluated against the Abbott RealTime PCR m2000rt system...
September 13, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28901134/diagnosis-of-tuberculosis-using-colorimetric-gold-nanoparticles-on-a-paper-based-analytical-device
#17
Tsung-Ting Tsai, Chia-Yu Huang, Chung-An Chen, Shu-Wei Shen, Mei-Chia Wang, Chao-Min Cheng, Chien-Fu Chen
We have developed a colorimetric sensing strategy employing gold nanoparticles and a paper-based analytical platform for the diagnosis of tuberculosis (TB). By utilizing the surface plasmon resonance effect, we were able to monitor changes in the color of a gold nanoparticle colloid based on the effects of single-stranded DNA probe molecules hybridizing with targeted double-stranded TB DNA. The hybridization event changes the surface charge density of the nanoparticles, causing them to aggregate to various degrees, which modifies the color of the solution in a manner that can be readily measured to determine the concentration of the targeted DNA analyte...
September 13, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28891543/a-survey-of-asthma-management-practices-and-implementation-of-global-initiative-for-asthma-guidelines-among-doctors-in-a-resource-limited-setting-in-nigeria
#18
E I Chima, M O Iroezindu, N R Uchenna, G O Mbata, C G Okwuonu
BACKGROUND: Bronchial asthma is a global health problem that causes significant morbidity and mortality in all age groups. Global Initiative for Asthma (GINA) seeks to standardize the care asthma patients receive. We assessed the knowledge, attitude, and practices of doctors in Umuahia, Southeast Nigeria, regarding asthma and determined the extent to which they abide by GINA guidelines in their management of asthma. METHODOLOGY: It was a descriptive cross-sectional study...
August 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28891170/design-and-evaluation-of-cryodevice-an-easy-to-use-apparatus-for-maintenance-of-optimum-temperature-during-cryoglobulin-assay
#19
Praveen K Veerasubramanian, Jayakanthan Kabeerdoss, Pulukool Sandhya, Suresh Devasahayam, Debashish Danda
INTRODUCTION: Maintenance of temperature during collection and transport of blood is an important pre-requisite for cryoglobulin assays. In this manuscript, we describe 'cryodevice', a low-cost device for transportation and/or incubation of vials of whole blood at 37°C. Such a device would reduce false negatives in cryoglobulin assays. METHOD: The 'cryodevice' takes the embodiment of a portable, light, insulated water bath, which can be used as an incubator in a plugged-in state, or as a transport container after it is set up and disconnected from the power supply...
September 11, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28890948/green-environment-and-incident-depression-in-south-africa-a-geospatial-analysis-and-mental-health-implications-in-a-resource-limited-setting
#20
Andrew Tomita, Alain M Vandormael, Diego Cuadros, Enrico Di Minin, Vuokko Heikinheimo, Frank Tanser, Rob Slotow, Jonathan K Burns
BACKGROUND: Unprecedented levels of habitat transformation and rapid urbanisation are changing the way individuals interrelate with the natural environment in developing countries with high economic disparities. Although the potential benefit of green environments for mental health has been recognised, population-level evidence to this effect is scarce. We investigated the effect of green living environment in potentially countering incident depression in a nationally representative survey in South Africa...
July 2017: The Lancet. Planetary health
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