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https://www.readbyqxmd.com/read/28324802/pelvic-exenteration-case-series-a-single-surgeon-s-experience-at-one-institution-in-trinidad-and-tobago
#1
Ravi Maharaj, Vandana Devika Sookdeo, Maurice Fortuné, Meenakshi Akhilesh, Chalapathi Rao Adidam Venkata, Wayne Mohammed, Dave Harnanan, Wayne A Warner
INTRODUCTION: Pelvic exenteration (PE) is an ultra-radical surgical procedure characterized by the en bloc resection of the pelvic organs. METHODS: In this case series, we report retrospectively on four patients who underwent PE in Trinidad and Tobago from 2012 to 2016. One male patient had rectal cancer while one each of three women had cervical, colon, or rectal cancer. RESULTS: Early postoperative complications (≤30days) occurred in all patients, while late complications (>30days) occurred in one patient (Grade 1 - Clavien-Dindo classification)...
March 7, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28323868/-waiting-for-daas-a-retrospective-chart-review-of-patients-with-untreated-hepatitis-c-in-rwanda
#2
Neil Gupta, Jules Kabahizi, Constance Mukabatsinda, Timothy David Walker, Emmanuel Musabeyezu, Athanase Kiromera, Jennifer Ilo Van Nuil, Kevin Steiner, Joia Mukherjee, Sabin Nsanzimana, Aimable Mbituyumuremyi
BACKGROUND: Access to treatment for hepatitis C virus (HCV) in sub-Saharan Africa is extremely limited. With the advent of direct acting antivirals (DAAs), highly effective and easy-to-deliver oral regimens are now available on the global market. This study was conducted to understand the background and characteristics of a national cohort of patients with HCV infection enrolled in care and awaiting therapy with DAAs. METHODS AND FINDINGS: We conducted a retrospective chart review of all adult patients with confirmed HCV infection who were currently enrolled in care and treatment at the four existing hepatitis referral centers in Rwanda...
2017: PloS One
https://www.readbyqxmd.com/read/28318805/kts-and-crams-were-useful-trauma-scores-in-a-resource-limited-settings
#3
Liyuan Peng, Hai Hu, Yarong He, Maoni Zeng, Haoyu Wang, Di Hao, Peng Yao, Yuming Shao, Yu Cao
No abstract text is available yet for this article.
March 14, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28317904/robust-and-elastic-lunar-and-martian-structures-from-3d-printed-regolith-inks
#4
Adam E Jakus, Katie D Koube, Nicholas R Geisendorfer, Ramille N Shah
Here, we present a comprehensive approach for creating robust, elastic, designer Lunar and Martian regolith simulant (LRS and MRS, respectively) architectures using ambient condition, extrusion-based 3D-printing of regolith simulant inks. The LRS and MRS powders are characterized by distinct, highly inhomogeneous morphologies and sizes, where LRS powder particles are highly irregular and jagged and MRS powder particles are rough, but primarily rounded. The inks are synthesized via simple mixing of evaporant, surfactant, and plasticizer solvents, polylactic-co-glycolic acid (30% by solids volume), and regolith simulant powders (70% by solids volume)...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317856/a-smartphone-based-diagnostic-platform-for-rapid-detection-of-zika-chikungunya-and-dengue-viruses
#5
Aashish Priye, Sara W Bird, Yooli K Light, Cameron S Ball, Oscar A Negrete, Robert J Meagher
Current multiplexed diagnostics for Zika, dengue, and chikungunya viruses are situated outside the intersection of affordability, high performance, and suitability for use at the point-of-care in resource-limited settings. Consequently, insufficient diagnostic capabilities are a key limitation facing current Zika outbreak management strategies. Here we demonstrate highly sensitive and specific detection of Zika, chikungunya, and dengue viruses by coupling reverse-transcription loop-mediated isothermal amplification (RT-LAMP) with our recently developed quenching of unincorporated amplification signal reporters (QUASR) technique...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317491/predictive-value-of-the-leukocyte-esterase-test-for-the-detection-of-pleocytosis-in-cerebrospinal-fluid
#6
Shervin Shokouhi, Ilad Alavi Darazam, Mehdi Karamipour, HasanAli Ahmadi, Mohammad M Sajadi
BACKGROUND: Rapid and accurate diagnostic tests for patients with suspected bacterial meningitis is crucial to prevent subsequent mortality and morbidity. We carried out this study to determine diagnostic value of the rapid leukocyte esterase (LE) strip test to identify PMN pleocytosis in cerebral spinal fluid. METHODS: A total of 126 patients with suspected meningitis were enrolled in this prospective study. Microscopic examination (cell count and differential) and leukocyte esterase (LE) rapid strip test was performed on cerebrospinal fluid (CSF) samples...
March 17, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28315043/the-intensive-care-medicine-clinical-research-agenda-in-paediatrics
#7
REVIEW
Mark J Peters, Andrew Argent, Marino Festa, Stéphane Leteurtre, Jefferson Piva, Ann Thompson, Douglas Willson, Pierre Tissières, Marisa Tucci, Jacques Lacroix
BACKGROUND: Intensive Care Medicine set us the task of outlining a global clinical research agenda for paediatric intensive care (PIC). In line with the clinical focus of this journal, we have limited this to research that may directly influence patient care. METHODS: Clinician researchers from PIC research networks of varying degrees of formality from around the world were invited to answer two main questions: (1) What have been the major recent advances in paediatric critical care research? (2) What are the top 10 studies for the next 10 years? RESULTS: (1) Inclusive databases are well established in many countries...
March 17, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28314488/building-sustainable-local-capacity-for-global-health-research-in-west-africa
#8
Nadia A Sam-Agudu, Elijah Paintsil, Muktar H Aliyu, Awewura Kwara, Folasade Ogunsola, Yaw A Afrane, Chima Onoka, Gordon A Awandare, Gladys Amponsah, Llewellyn J Cornelius, Gabou Mendy, Rachel Sturke, Anita Ghansah, George K Siberry, Echezona E Ezeanolue
BACKGROUND: Global health research in resource-limited countries has been largely sponsored and led by foreign institutions. Thus, these countries' training capacity and productivity in global health research is limited. Local participation at all levels of global health knowledge generation promotes equitable access to evidence-based solutions. Additionally, leadership inclusive of competent local professionals promotes best outcomes for local contextualization and implementation of successful global health solutions...
November 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28306597/diagnosis-of-viral-hepatitis
#9
Philippa J Easterbrook, Teri Roberts, Anita Sands, Rosanna Peeling
PURPOSE OF REVIEW: Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and HIV-HBV and HCV coinfection are major causes of chronic liver disease worldwide. Testing and diagnosis is the gateway for access to both treatment and prevention services, but there remains a large burden of undiagnosed infection globally. We review the global epidemiology, key challenges in the current hepatitis testing response, new tools to support the hepatitis global response (2016-2020 Global Hepatitis Health Sector strategy, and 2017 WHO guidelines on hepatitis testing and their key recommendations) and future directions and innovations in hepatitis diagnostics...
March 16, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28303825/evaluation-of-loop-mediated-isothermal-amplification-assay-for-rapid-diagnosis-of-acanthamoeba-keratitis
#10
Abhishek Mewara, Sumeeta Khurana, Shakila Yoonus, Kirti Megha, Parveen Tanwar, Amit Gupta, Rakesh Sehgal
BACKGROUND: The clinical features of Acanthamoeba keratitis (AK) are non-specific and closely resemble bacterial, viral and fungal keratitis. MATERIALS AND METHODS: We compared loop-mediated isothermal amplification (LAMP) with microscopy, non-nutrient agar (NNA) culture and polymerase chain reaction (PCR) in clinical suspects of AK. RESULTS: Of 52 clinical samples (42 AK suspects and 10 proven bacterial, viral or fungal keratitis), 3 were positive by direct microscopy (sensitivity 60%, confidence interval [CI]: 17%-92...
January 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28299376/proximity-to-healthcare-clinic-and-depression-risk-in-south-africa-geospatial-evidence-from-a-nationally-representative-longitudinal-study
#11
Andrew Tomita, Alain M Vandormael, Diego Cuadros, Rob Slotow, Frank Tanser, Jonathan K Burns
Proximity to primary healthcare facilities may be a serious barrier to accessing mental health services in resource-limited settings. In this study, we examined whether the distance to the primary healthcare clinic (PHCC) was associated with risk of depression in KwaZulu-Natal Province, South Africa. Depressive symptoms and household coordinates data were accessed from the nationally representative South African National Income Dynamics Study. Distances between households and their nearest PHCCs were calculated and mixed-effects logistic regression models fitted to the data...
March 15, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28299157/low-coverage-of-hepatitis-b-vaccine-and-determinants-among-health-professionals-working-in-amhara-regional-state-hospitals-ethiopia
#12
Berhanu Elfu Feleke
More than two billion people have been infected with hepatitis B virus (HBV), 360 million have chronic infection and 600,000 die each year from HBV-related liver disease or hepatocellular carcinoma. Each year more than 66,000 health professionals are infected by hepatitis b virus and vaccination against hepatitis B saves the life's of these health professionals. The aim of this study was to determine the prevalence and associated factors of hepatitis B vaccine coverage in a resource limited settings. A cross sectional study design was conducted...
December 31, 2016: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28298207/understanding-low-uptake-of-contraceptives-in-resource-limited-settings-a-mixed-methods-study-in-rural-burundi
#13
M Ndayizigiye, M C Smith Fawzi, C Thompson Lively, N C Ware
BACKGROUND: Family planning can reduce deaths, improve health, and facilitate economic development in resource-limited settings. Yet, modern contraceptive methods are often underused. This mixed-methods study, conducted in rural Burundi, sought to explain low uptake of contraceptives by identifying utilization barriers. Results may inform development of family planning interventions in Burundi and elsewhere. METHODS: We investigated uptake of contraceptives among women of reproductive age in two rural districts of Burundi, using an explanatory sequential, mixed-methods research design...
March 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28295179/platelets-and-infections-in-the-resource-limited-countries-with-a-focus-on-malaria-and-viral-haemorrhagic-fevers
#14
REVIEW
Jecko Thachil
Infections continue to cause a high incidence of mortality and morbidity in resource-poor nations. Although antimicrobial therapy has aided mostly in dealing with the pathogenic micro-organisms themselves, the collateral damage caused by the infections continue to cause many deaths. Intensive care support and manipulation of the hosts' abnormal response to the infection have helped to improve mortality in well-resourced countries. But, in those areas with limited resources, this is not yet the case and simpler methods of diagnosis and interventions are required...
March 14, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28291809/impact-of-a-structured-icu-training-programme-in-resource-limited-settings-in-asia
#15
Rashan Haniffa, Yoel Lubell, Ben S Cooper, Sanjib Mohanty, Shamsul Alam, Arjun Karki, Rajya Pattnaik, Ahmed Maswood, R Haque, Raju Pangeni, Marcus J Schultz, Arjen M Dondorp
OBJECTIVE: To assess the impact on ICU performance of a modular training program in three resource-limited general adult ICUs in India, Bangladesh, and Nepal. METHOD: A modular ICU training programme was evaluated using performance indicators from June 2009 to June 2012 using an interrupted time series design with an 8 to 15 month pre-intervention and 18 to 24 month post-intervention period. ICU physicians and nurses trained in Europe and the USA provided training for ICU doctors and nurses...
2017: PloS One
https://www.readbyqxmd.com/read/28290470/descriptive-study-of-earthquake-related-spinal-cord-injury-in-nepal
#16
C C Groves, M K Poudel, M Baniya, C Rana, D R House
STUDY DESIGN: Descriptive study. OBJECTIVES: To describe the epidemiological features of spinal cord injury (SCI) following the 2015 earthquakes in Nepal. SETTING: Spinal Injury Rehabilitation Centre, Kavre, Nepal. METHODS: Data were collected from the medical records of all earthquake-related patients seen from 25 April 2015 through to 16 June 2016. Data collected included patient demographics, mechanism of injury, initial medical treatment, neurological assessment, complications, neurological/functional outcomes and length of stay...
March 14, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28289370/energetic-constraints-produce-self-sustained-oscillatory-dynamics-in-neuronal-networks
#17
Javier Burroni, P Taylor, Cassian Corey, Tengiz Vachnadze, Hava T Siegelmann
Overview: We model energy constraints in a network of spiking neurons, while exploring general questions of resource limitation on network function abstractly. Background: Metabolic states like dietary ketosis or hypoglycemia have a large impact on brain function and disease outcomes. Glia provide metabolic support for neurons, among other functions. Yet, in computational models of glia-neuron cooperation, there have been no previous attempts to explore the effects of direct realistic energy costs on network activity in spiking neurons...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28286783/decreasing-incidence-of-cutaneous-chemical-burns-in-a-resource-limited-burn-centre-is-this-a-positive-effect-of-modernization
#18
R E E Nnabuko, C P Okoye, I S Ogbonnaya, Egi Isiwele
BACKGROUND: Burns present a devastating injury to patients. Burns caused by chemical agents, present a worse scenario. In a resource limited country like Nigeria, readily available sources of these corrosive agents are mainly from lead-acid battery vendors and to some extent local small scale soap manufacturers who use caustic soda. We hypothesized that with the reduction in small scale soap manufacturing and increasing trend towards modernization in the use of dry cell batteries, chemical burns may be on the decline, and we sought to investigate this...
2017: Burns and trauma
https://www.readbyqxmd.com/read/28285287/disseminated-cryptococcosis-in-an-immunocompetent-toddler
#19
Neeraj Gupta, Anil Sachdev, Dhiren Gupta, Nita Radhakrishnan
BACKGROUND: Immunodeficient children are more prone for invasive cryptococcal infections. CASE CHARACTERISTICS: A 2-year-old boy with disseminated cryptococcosis was evaluated for underlying immunodeficiency without success. INTERVENTION/OUTCOME: Child was managed successfully. MESSAGE: Immunocompetent children with disseminated cryptococcosis can present diagnostic or therapeutic challenge in resource-limited settings...
February 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28281576/incidence-and-outcomes-of-uterine-rupture-among-women-with-prior-caesarean-section-who-multicountry-survey-on-maternal-and-newborn-health
#20
Kenichiro Motomura, Togoobaatar Ganchimeg, Chie Nagata, Erika Ota, Joshua P Vogel, Ana Pilar Betran, Maria Regina Torloni, Kapila Jayaratne, Seung Chik Jwa, Suneeta Mittal, Zenaida Dy Recidoro, Kenji Matsumoto, Mikiya Fujieda, Idi Nafiou, Khalid Yunis, Zahida Qureshi, Joao Paulo Souza, Rintaro Mori
Caesarean section (CS) is increasing globally, and women with prior CS are at higher risk of uterine rupture in subsequent pregnancies. However, little is known about the incidence, risk factors, and outcomes of uterine rupture in women with prior CS, especially in developing countries. To investigate this, we conducted a secondary analysis of the World Health Organization Multicountry Survey on Maternal and Newborn Health, which included data on delivery from 359 facilities in 29 countries. The incidence of uterine rupture among women with at least one prior CS was 0...
March 10, 2017: Scientific Reports
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