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https://www.readbyqxmd.com/read/18630122/application-of-multiplex-pcr-with-histopathologic-features-for-detection-of-familial-breast-cancer-in-formalin-fixed-paraffin-embedded-histologic-specimens
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H Rassi, M Houshmand, M Hashemi, K Majidzadeh, M H Hosseini Akbari, M Shafa Shariat Panahi
Breast cancer is the most common malignancy among females in the world. Age and familial history are the major risk factors for the development of this disease in Iran. Mutations of BRCA1 and BRCA2 genes are associated with a greatly increased risk for development of familial breast cancer. Frequency of BRCA mutations was identified in familial breast cancers (FBC) and non-familial breast cancers (NFBC) by molecular genetics, morphological and Immunohistochemical methods. Thirty forth formalin-fixed, paraffin-embedded breast tissue tumors were analyzed from 16 patients with FBC and 18 patients with NFBC...
March 2008: T︠S︡itologii︠a︡ i Genetika
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