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Hepatic cyst insulin growth factor

Domenico Alvaro, Paolo Onori, Gianfranco Alpini, Antonio Franchitto, Douglas M Jefferson, Alessia Torrice, Vincenzo Cardinale, Fabrizio Stefanelli, Maria Grazia Mancino, Mario Strazzabosco, Mario Angelico, Adolfo Attili, Eugenio Gaudio
We evaluated the morphological and functional features of hepatic cyst epithelium in adult autosomal dominant polycystic kidney disease (ADPKD). In six ADPKD patients, we investigated the morphology of cyst epithelium apical surface by scanning electron microscopy and the expression of estrogen receptors (ERs), insulin-like growth factor 1 (IGF1), IGF1 receptors (IGF1-R), growth hormone receptor, the proliferation marker proliferating cell nuclear antigen, and pAKT by immunohistochemistry and immunofluorescence...
February 2008: American Journal of Pathology
Olgica Nedić, Anna J Nikolić, Ivona Baricević, Biljana Jovanović, Natasa Ilić
BACKGROUND: Insulin-like growth factors (IGFs) are polypeptide hormones that play anabolic roles in cellular growth and metabolism. Their activity is regulated by binding proteins (IGFBPs) and degradation mechanisms. The liver is regarded as the main source of circulating forms and the levels change in various disease states. The aim of the study was to explore the effects of parasitic infections on the circulating IGFs and IGFBPs. METHODS: Peptide concentrations in sera of patients with echinococcosis, trichinellosis and toxoplasmosis were measured by radioimmunoassay, while IGFBP patterns were characterised by ligand-affinity blotting and gel chromatography...
September 2003: Clinica Chimica Acta; International Journal of Clinical Chemistry
Shigehiko Yoshida, Masaki Nio, Yutaka Hayashi, Ryoji Ohi, Ikuo Kawamura, Toshio Goto
BACKGROUND/PURPOSE: Low level of Insulinlike growth factor-I (IGF-I) has been reported in children with chronic liver disease like biliary atresia (BA) awaiting liver transplantation. However, there has been no report on IGF-I in BA managed without liver transplantation. METHODS: The authors measured IGF-I and growth hormone (GH) in 21 postoperative BA, and 17 choledochal cysts (CC) as a control with normal liver function. To avoid an influence of aging, IGF-I was analyzed after converting them into a newly defined index "IGF%...
February 2003: Journal of Pediatric Surgery
Mehmet Riza Altiparmak, Rezzan Ataman, Resat Ozaras, Veysel Tahan, Seval Aydin, Hafize Uzun, Kamil Serdengecti, Teoman Soysal
BACKGROUND AND AIM: Although the majority of patients with end stage renal failure have anemia, some have relative erythrocytosis. Patients treated with continuous ambulatory peritoneal dialysis (CAPD) having relative erythrocytosis were studied in order to determine the factors that would be responsible. METHODS: Nine out of 89 CAPD patients (10%) were identified as having relative erythrocytosis. Age-, sex- and duration of disease-matched eight patients undergoing CAPD were taken as control...
January 2002: Renal Failure
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