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pediatric NMO

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https://www.readbyqxmd.com/read/27746022/association-between-demyelinating-disease-and-autoimmune-rheumatic-disease-in-a-pediatric-population
#1
Ana Luiza M Amorim, Nadia C Cabral, Fabiane M Osaku, Claudio A Len, Enedina M L Oliveira, Maria Teresa Terreri
INTRODUCTION: Multiple sclerosis (MS) and neuromyelitis optica (NMO) are demyelinating diseases of the central nervous system. Autoimmunity in patients with demyelinating disease and in their families has been broadly investigated and discussed. Recent studies show a higher incidence of rheumatic autoimmune diseases among adult patients with MS or NMO and their families, but there are no studies in the pediatric population. OBJECTIVE: To evaluate an association of MS and NMO with autoimmune rheumatic diseases in pediatric patients...
September 28, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27742816/a-nationwide-survey-of-pediatric-acquired-demyelinating-syndromes-in-japan
#2
Y Yamaguchi, H Torisu, R Kira, Y Ishizaki, Y Sakai, M Sanefuji, T Ichiyama, A Oka, T Kishi, S Kimura, M Kubota, J Takanashi, Y Takahashi, H Tamai, J Natsume, S Hamano, S Hirabayashi, Y Maegaki, M Mizuguchi, K Minagawa, H Yoshikawa, J Kira, S Kusunoki, T Hara
OBJECTIVE: To investigate the clinical and epidemiologic features of pediatric acquired demyelinating syndromes (ADS) of the CNS in Japan. METHODS: We conducted a nationwide survey and collected clinical data on children with ADS aged 15 years or younger, who visited hospitals between 2005 and 2007. RESULTS: Among 977 hospitals enrolled, 723 (74.0%) responded to our inquiries and reported a total of 439 patients as follows: 244 with acute disseminated encephalomyelitis (ADEM), 117 with multiple sclerosis (MS), 14 with neuromyelitis optica (NMO), and 64 with other ADS...
November 8, 2016: Neurology
https://www.readbyqxmd.com/read/27572863/neuromyelitis-optica-spectrum-disorders-in-children-and-adolescents
#3
Silvia Tenembaum, Tanuja Chitnis, Ichiro Nakashima, Nicolas Collongues, Andrew McKeon, Michael Levy, Kevin Rostasy
Neuromyelitis optica (NMO) is a severe autoimmune disease of the CNS characterized by recurrent inflammatory events primarily involving the optic nerves and spinal cord. NMO is infrequent in children, but early recognition is important to start adequate treatment. In this article, we review the evolving diagnostic criteria of NMO and provide an update on the clinical and neuroimaging spectrum of the disorder in pediatric patients, including current knowledge on immunopathogenesis and treatment recommendations for children with NMO...
August 30, 2016: Neurology
https://www.readbyqxmd.com/read/27572861/pediatric-transverse-myelitis
#4
Michael Absoud, Benjamin M Greenberg, Ming Lim, Tim Lotze, Terrence Thomas, Kumaran Deiva
Pediatric acute transverse myelitis (ATM) is an immune-mediated CNS disorder and contributes to 20% of children experiencing a first acquired demyelinating syndrome (ADS). ATM must be differentiated from other presentations of myelopathy and may be the first presentation of relapsing ADS such as neuromyelitis optica (NMO) or multiple sclerosis (MS). The tenets of the diagnostic criteria for ATM established by the Transverse Myelitis Consortium Working Group can generally be applied in children; however, a clear sensory level may not be evident in some...
August 30, 2016: Neurology
https://www.readbyqxmd.com/read/27383405/elevated-baseline-cortisol-levels-are-predictive-of-bad-outcomes-in-critically-ill-children
#5
Yael Levy-Shraga, Orit Pinhas-Hamiel, Vered Molina-Hazan, Liran Tamir-Hostovsky, Zeev Motti Eini, Liat Lerner-Geva, Gideon Paret
OBJECTIVE: The definition of an adequate adrenal response in critically ill children continues to be controversial. We aimed to evaluate the cortisol levels at baseline and after adrenocorticotropin (ACTH) stimulation and determine their association to clinical outcome of critically ill children. METHODS: All children who underwent an ACTH test in the pediatric intensive care unit (PICU) in a tertiary medical center between 2006 and 2013 were included in the study...
July 2, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27261688/pediatric-demyelination
#6
Sona Narula, Brenda Banwell
PURPOSE OF REVIEW: This review summarizes a general approach to pediatric demyelination as well as specific features of each of the acquired demyelinating syndromes to help clinicians in their evaluation of children with these disorders. Case studies are included to illustrate the expanding phenotype of many of these syndromes. RECENT FINDINGS: With the creation of consensus definitions for the pediatric acquired demyelinating syndromes, recognition of demyelination in children has increased, as has understanding of the clinical and radiologic features, prognosis, and response to treatment...
August 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27157418/neuromyelitis-optica-spectrum-disorder-nmosd-a-new-concept
#7
REVIEW
J de Sèze, L Kremer, N Collongues
The relationship between neuromyelitis optica (NMO) and multiple sclerosis (MS) has long been controversial. NMO was previously considered a form of MS involving predominantly the spinal cord and optic nerve. However, since the discovery of NMO-IgG/aquaporin-4 (AQP4) antibody, an NMO-specific autoantibody to AQP4, some unique clinical features, and magnetic resonance imaging (MRI) and other laboratory findings in NMO, have been further clarified. AQP4 antibody is now the most important laboratory finding for the diagnosis of NMO...
April 2016: Revue Neurologique
https://www.readbyqxmd.com/read/26819962/rituximab-monitoring-and-redosing-in-pediatric-neuromyelitis-optica-spectrum-disorder
#8
Margherita Nosadini, Gulay Alper, Catherine J Riney, Leslie A Benson, Shekeeb S Mohammad, Sudarshini Ramanathan, Melinda Nolan, Richard Appleton, Richard J Leventer, Kumaran Deiva, Fabienne Brilot, Mark P Gorman, Amy T Waldman, Brenda Banwell, Russell C Dale
OBJECTIVE: To study rituximab in pediatric neuromyelitis optica (NMO)/NMO spectrum disorders (NMOSD) and the relationship between rituximab, B cell repopulation, and relapses in order to improve rituximab monitoring and redosing. METHODS: Multicenter retrospective study of 16 children with NMO/NMOSD receiving ≥2 rituximab courses. According to CD19 counts, events during rituximab were categorized as "repopulation," "depletion," or "depletion failure" relapses (repopulation threshold CD19 ≥10 × 10(6) cells/L)...
February 2016: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/26683648/clinical-features-of-neuromyelitis-optica-in-children-us-network-of-pediatric-ms-centers-report
#9
MULTICENTER STUDY
Tanuja Chitnis, Jayne Ness, Lauren Krupp, Emmanuelle Waubant, Tyler Hunt, Cody S Olsen, Moses Rodriguez, Tim Lotze, Mark Gorman, Leslie Benson, Anita Belman, Bianca Weinstock-Guttman, Greg Aaen, Jennifer Graves, Marc Patterson, John W Rose, T Charles Casper
OBJECTIVE: To compare clinical features of pediatric neuromyelitis optica (NMO) to other pediatric demyelinating diseases. METHODS: Review of a prospective multicenter database on children with demyelinating diseases. Case summaries documenting clinical and laboratory features were reviewed by an adjudication panel. Diagnoses were assigned in the following categories: multiple sclerosis (MS), acute disseminated encephalomyelitis, NMO, and recurrent demyelinating disease not otherwise specified...
January 19, 2016: Neurology
https://www.readbyqxmd.com/read/26616865/increased-interleukin-6-correlates-with-myelin-oligodendrocyte-glycoprotein-antibodies-in-pediatric-monophasic-demyelinating-diseases-and-multiple-sclerosis
#10
Philippe Horellou, Min Wang, Vixra Keo, Pascale Chrétien, Ché Serguera, Patrick Waters, Kumaran Deiva
Acquired demyelinating syndromes (ADS) in children evolve either as a monophasic disease diagnosed as acute demyelinating encephalomyelitis (ADEM), transverse myelitis (TM) or optic neuritis (ON), or a multiphasic one with several relapses most often leading to the diagnosis of multiple sclerosis (MS) or neuromyelitis optica (NMO). These neuroinflammatory disorders are increasingly associated with autoantibodies against proteins such as aquaporin-4 in rare instances, and more frequently against myelin oligodendrocyte glycoprotein (MOG)...
December 15, 2015: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/26538850/multisystem-involvement-in-neuromyelitis-optica
#11
Megan M Langille, Jay Desai
We describe a case of pediatric neuromyelitis optica (NMO) with muscle and lung involvement in addition to central nervous system disease. Our patient initially presented with features of area postrema syndrome, then subsequently with optic neuritis. The patient also had recurrent hyperCKemia that responded to corticosteroids. Finally, axillary and hilar adenopathy with pulmonary consolidation were noted as well and responded to immunomodulation. Our case highlights multisystem involvement in NMO including non-infectious pulmonary findings which have not been described in the pediatric population previously...
September 2015: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/26538849/acquired-demyelinating-disorders-of-central-nervous-system-a-pediatric-cohort
#12
Sheffali Gulati, Biswaroop Chakrabarty, Atin Kumar, Puneet Jain, Harsh Patel, Lokesh Saini
OBJECTIVE: This is a retrospective chart review of consecutive children with acquired demyelinating disorders presenting to a north Indian tertiary care hospital over 4 years. The aim of this review is to describe all the patients (with single event as well as those with recurrences) with detailed description of those who recurred. MATERIALS AND METHODS: Overall 35 cases were reviewed and their clinical presentations, diagnosis, management, and follow-up are being presented...
September 2015: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/26388586/neuromyelitis-optica-in-children-a-review-of-the-literature
#13
REVIEW
Eda Derle, H Nalan Güneş, Bahadır Konuşkan, Aslı Tuncer-Kurne
Neuromyelitis optica (NMO) is a rare and severe inflammatory disease of the central nervous system (CNS), which constitutes up to 5% of pediatric aquired demyelinating diseases. The optic nerves and the spinal cord are the most affected sites. The discovery of an autoantibody called NMO-IgG, which targets aquaporin-4, the main water channel in the CNS, gave a new direction to understanding the underlying immunologic mechanisms. This specific biomarker also helps to distinguish the disease from other demyelinating disorders...
November 2014: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/26182501/-clinical-characteristics-and-follow-up-of-pediatric-patients-with-neuromyelitis-optica-and-neuromyelitis-optica-spectrum-disorders
#14
Wu Yun, Zhang Weihua, Ren Xiaotun, Li Jiuwei, Yang Xinying, Lyu Junlan, Ding Changhong, Chen Chunhong, Ren Haitao, Cui Liying, Fang Fang
OBJECTIVE: To analyze the clinical characteristics of pediatric neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorders (NMOSD). METHOD: A retrospective analysis was performed evaluating clinical and laboratory characteristics of ten NMO and NMOSD children who were seen in our hospital from December 2010 to May 2014. Median age at onset was 8.9 years (range 0.8-13.8 years). Seven cases were female and three were male. Median disease duration was 1...
April 2015: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/26092914/international-consensus-diagnostic-criteria-for-neuromyelitis-optica-spectrum-disorders
#15
Dean M Wingerchuk, Brenda Banwell, Jeffrey L Bennett, Philippe Cabre, William Carroll, Tanuja Chitnis, Jérôme de Seze, Kazuo Fujihara, Benjamin Greenberg, Anu Jacob, Sven Jarius, Marco Lana-Peixoto, Michael Levy, Jack H Simon, Silvia Tenembaum, Anthony L Traboulsee, Patrick Waters, Kay E Wellik, Brian G Weinshenker
Neuromyelitis optica (NMO) is an inflammatory CNS syndrome distinct from multiple sclerosis (MS) that is associated with serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). Prior NMO diagnostic criteria required optic nerve and spinal cord involvement but more restricted or more extensive CNS involvement may occur. The International Panel for NMO Diagnosis (IPND) was convened to develop revised diagnostic criteria using systematic literature reviews and electronic surveys to facilitate consensus. The new nomenclature defines the unifying term NMO spectrum disorders (NMOSD), which is stratified further by serologic testing (NMOSD with or without AQP4-IgG)...
July 14, 2015: Neurology
https://www.readbyqxmd.com/read/26058738/a-case-report-on-juvenile-neuromyelitis-optica-early-onset-long-remission-period-and-atypical-treatment-response
#16
Christiane Elpers, Catharina C Gross, Barbara Fiedler, Sven G Meuth, Gerhard Kurlemann
Neuromyelitis optica (NMO) is a severe inflammatory demyelinating disease of the central nervous system and preferentially targets the optic nerves and spinal cord. NMO is rare in children and clinical course of the disease is highly variable as described in studies. Here, we present a case report of a young girl presenting with a rare course of pediatric NMO with an early disease onset at the age of 12 years, a relapse free interval of 4 years, evidence of NMO immunoglobulin G (IgG) and an unusual response against immunosuppressive therapy...
August 2015: Neuropediatrics
https://www.readbyqxmd.com/read/26041801/clinical-and-mri-phenotype-of-children-with-mog-antibodies
#17
Cristina Fernandez-Carbonell, David Vargas-Lowy, Alexander Musallam, Brian Healy, Katherine McLaughlin, Kai W Wucherpfennig, Tanuja Chitnis
OBJECTIVE: To investigate the clinical and magnetic resonance imaging (MRI) features of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-seropositive pediatric demyelinating syndromes. METHODS: Serum samples collected from 74 children with suspected demyelinating disorders whom were being followed at Massachusetts General Hospital were incubated with control green fluorescent protein (GFP)- and MOG-GFP-transfected Jurkat cell clones. The binding ratios were calculated using flow cytometry...
February 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/25889963/anti-mog-antibodies-are-present-in-a-subgroup-of-patients-with-a-neuromyelitis-optica-phenotype
#18
Anne-Katrin Pröbstel, Gabrielle Rudolf, Klaus Dornmair, Nicolas Collongues, Jean-Baptiste Chanson, Nicholas S R Sanderson, Raija L P Lindberg, Ludwig Kappos, Jérôme de Seze, Tobias Derfuss
BACKGROUND: Antibodies against myelin oligodendrocyte glycoprotein (MOG) have been identified in a subgroup of pediatric patients with inflammatory demyelinating disease of the central nervous system (CNS) and in some patients with neuromyelitis optica spectrum disorder (NMOSD). The aim of this study was to examine the frequency, clinical features, and long-term disease course of patients with anti-MOG antibodies in a European cohort of NMO/NMOSD. FINDINGS: Sera from 48 patients with NMO/NMOSD and 48 patients with relapsing-remitting multiple sclerosis (RR-MS) were tested for anti-aquaporin-4 (AQP4) and anti-MOG antibodies with a cell-based assay...
2015: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/25520954/rituximab-as-a-first-line-preventive-treatment-in-pediatric-nmosds-preliminary-results-in-5-children
#19
Giulia Longoni, Brenda Banwell, Massimo Filippi, E Ann Yeh
OBJECTIVE: No established therapeutic protocol has been proposed to date for childhood-onset neuromyelitis optica (NMO) spectrum disorders (NMOSDs). We report the response of 5 NMO immunoglobulin (Ig)G-positive pediatric cases to a standardized B-cell-targeted first-line immunosuppressive protocol with rituximab for prevention of relapses. METHODS: Retrospective observational cohort study. RESULTS: All patients included in the study showed disease remission after rituximab induction...
December 2014: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/25518394/-pathogenesis-of-autoantibodies-in-demyelinating-disorders-of-the-central-nervous-system
#20
Keiko Tanaka, Masami Tanaka
Several autoantibodies in relation to central nervous system demyelinating diseases (CDD) have been reported. Among them, anti-aquaporin 4(AQP4) antibody in neuromyelitis optica (NMO) is a reliable marker for the diagnosis of NMO and the antibody is thought to be closely related to its pathogenesis. Another antibody, anti-myelin oligodendrocyte glycoprotein (MOG) antibody is recently recognized in relevance to CDD, especially in seronegative NMO. Anti-MOG antibodies are also paid attention in pediatric acute disseminated encephalomyelitis (ADEM) and optic neuritis, however the roles for the pathogenesis in these disorders are still not clear...
November 2014: Nihon Rinsho. Japanese Journal of Clinical Medicine
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