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pediatric ADEM

Y Yamaguchi, H Torisu, R Kira, Y Ishizaki, Y Sakai, M Sanefuji, T Ichiyama, A Oka, T Kishi, S Kimura, M Kubota, J Takanashi, Y Takahashi, H Tamai, J Natsume, S Hamano, S Hirabayashi, Y Maegaki, M Mizuguchi, K Minagawa, H Yoshikawa, J Kira, S Kusunoki, T Hara
OBJECTIVE: To investigate the clinical and epidemiologic features of pediatric acquired demyelinating syndromes (ADS) of the CNS in Japan. METHODS: We conducted a nationwide survey and collected clinical data on children with ADS aged 15 years or younger, who visited hospitals between 2005 and 2007. RESULTS: Among 977 hospitals enrolled, 723 (74.0%) responded to our inquiries and reported a total of 439 patients as follows: 244 with acute disseminated encephalomyelitis (ADEM), 117 with multiple sclerosis (MS), 14 with neuromyelitis optica (NMO), and 64 with other ADS...
October 14, 2016: Neurology
Gamze Ozgurhan, Oznur Vermezoglu, Didem Ocal Topcu, Adem Karbuz, Aysel Vehapoglu, Bulent Hacihamdioglu
Although rotavirus gastroenteritis is quite common in the pediatric population, secondary bacterial sepsis following rotavirus infection is a rare clinical entity. Gram-negative bacilli are the fifth most common cause of meningitis in infants but this infection rarely occurs after gastroenteritis. Here, we report a 2.5-month-old infant who developed Escherichia coli (E. coli) meningitis after acute rotavirus gastroenteritis. The 2.5-month-old male infant with fever, vomiting, and watery diarrhea that started 1 day earlier was admitted to the hospital...
2016: Case Reports in Infectious Diseases
Aysel Taktak, Nermin Uncu, Banu Acar, Şemsa Çaycı, Arzu Ensari, Gökçe Gür, Adem Köksoy, Nilgün Çakar
Acute tubulointerstitial nephritis (TIN) is a common cause of acute renal impairment, characterized by the infiltration of inflammatory cells in the interstitium of the kidney. We retrospectively reviewed the medical records of 19 acute TIN patients attended to our Pediatric Nephrology department between April 1999 and April 2014. Nineteen patients (7 boys and 12 girls) were evaluated. The median age was 14 years (range 7-19). Five were diagnosed as TIN histopathologically, fourteen patients were diagnosed as clinically...
November 2015: Turkish Journal of Pediatrics
Abdelrahim Abdrabou Sadek, Mostafa Ashry Mohamed, Ashraf Abou-Taleb, Marwa Ibrahim Mohammed
INTRODUCTION: Acute disseminated encephalomyelitis (ADEM) is an immune mediated disease of the brain. Although it occurs in all ages, most reported cases are in children and adolescents. The aims of this study were to study the clinical pattern and outcome of ADEM in children in a tertiary center in Upper Egypt and to determine the effect of combined use of steroids and IVIg on outcome. METHODS: This observational study was carried out from January 2014 through December 2014 in the Pediatric Department of Sohag University Hospital (Egypt)...
July 2016: Electronic Physician
Adem Binnetoglu, Berat Demir, Ali Cemal Yumusakhuylu, Tekin Baglam, Murat Sari
Importance: Secondary posttonsillectomy bleeding associated with oozing from multiple sites or overcauterized tonsillar bed deserves special evaluation. Objective: To evaluate the use of an absorbable, flowable gelatin-thrombin hemostatic matrix (GTHM) sealant for secondary bleeding after tonsillectomy. Design, Setting, and Participants: This was a retrospective data analysis, with information gathered from medical records of pediatric patients with secondary posttonsillectomy bleeding treated with the GTHM between 2012 and 2016 at a referral center and a local satellite facility...
October 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
Adem Gul, Adnan Cinal, Cagatey Caglar, Tekin Yasar, Adil Kilic
OBJECTIVE: To compare ocular biometry and central corneal thickness of unaffected healthy eyes of pediatric patients with monocular cataracts/corneal opacities and age- matched controls. MATERIALS AND METHODS: We studied 329 eyes of 329 children who were between 1 and 12 years old. The study group (n: 164) consisted of healthy fellow eyes of children operated for unilateral congenital/traumatic cataract and corneal laceration. Axial length, anterior chamber depth, lens thickness, vitreous chamber depth, and central corneal thickness were measured by ultrasound biometry/ pachymetry...
July 2015: Nepalese Journal of Ophthalmology
Murat Sutcu, Nuran Salman, Hacer Akturk, Nazan Dalgıc, Ozden Turel, Canan Kuzdan, Eda Kepenekli Kadayifci, Dicle Sener, Adem Karbuz, Zayre Erturan, Ayper Somer
BACKGROUND: The purpose of this study was to establish species distribution of Candida isolates from pediatric patients in Istanbul, Turkey, and to determine risk factors associated with nosocomial Candida infections. METHODS: This study was conducted between June 2013 and June 2014 by participation of 7 medical centers in Istanbul. Candida spp strains isolated from the clinical specimens of pediatric patients were included. Clinical features were recorded on a standardized data collection sheet...
June 20, 2016: American Journal of Infection Control
Kamini Gupta, Avik Banerjee, Kavita Saggar, Archana Ahluwalia, Karan Saggar
BACKGROUND: Infections of the central nervous system (CNS) are common and routinely encountered. Our aim was to evaluate the neuroimaging features of the various infections of the CNS so as to differentiate them from tumoral, vascular, and other entities that warrant a different line of therapy. AIMS: Our aim was to analyze the biochemical and magnetic resonance imaging (MRI) features in CNS infections. SETTINGS AND DESIGN: This was a longitudinal, prospective study over a period of 1½ years...
January 2016: Journal of Pediatric Neurosciences
Tamer Celik, Umit Celik, Mustafa Kömür, Orkun Tolunay, Riza Dincer Yildizdas, Begul Yagci-Kupeli, Fulya Kücük, İsmail Eroglu
OBJECTIVES: Lyme disease is a vector-associated infectious disease, caused by the agent, spirochete Borrelia burgdorferi. Neurologic findings are observed in approximately 12% of the cases and termed Lyme neuroborreliosis (LNB). Lyme neuroborreliosis may manifest with different clinical neurologic manifestations. METHODS: The study was conducted at tertiary training and research hospital. From January 2014 to September 2015, a total of 75 patients diagnosed with encephalitis, ataxia, Guillain Barre Syndrome (GBS), facial paralysis, acute disseminated encephalomyelitis (ADEM), pseudotumorcerebri were evaluated for inclusion to the study...
2016: Neuro Endocrinology Letters
Diederik L H Koelman, Salim Chahin, Soe S Mar, Arun Venkatesan, George M Hoganson, Anusha K Yeshokumar, Paula Barreras, Bittu Majmudar, Joshua P Klein, Tanuja Chitnis, David C Benkeser, Marco Carone, Farrah J Mateen
OBJECTIVE: To analyze the range of demographic, clinical, MRI, and CSF features of acute disseminated encephalomyelitis (ADEM), a rare, typically monophasic demyelinating disorder, and analyze long-term outcomes including time and risk factors for subsequent clinical events as well as competing diagnoses. METHODS: We performed a retrospective, multicenter study in 4 US academic medical centers of all patients clinically diagnosed with ADEM. Initial presentation of pediatric and adult ADEM and monophasic and multiphasic disease were compared...
May 31, 2016: Neurology
Salini Thulasirajah, Daniela Pohl, Jorge Davila-Acosta, Sunita Venkateswaran
Under the umbrella of pediatric-acquired demyelinating syndromes, there is a multitude of disorders, including optic neuritis, transverse myelitis, acute disseminated encephalomyelitis (ADEM), multiple sclerosis (MS), and neuromyelitis optica spectrum disorders (NMOSD). Due to overlapping clinical and magnetic resonance imaging (MRI) features, it can be challenging to provide an accurate diagnosis. In view of therapeutic and prognostic implications, an early and reliable diagnosis is however of utmost importance...
August 2016: Neuropediatrics
Kavita Thakkar, Stephen M Maricich, Gulay Alper
We categorized the causes of acute ataxia in the pediatric population-referred to the Division of Neurology-at a large, urban pediatric medical center. Of the 120 cases identified over the past 11 years, post-infectious cerebellar ataxia was the most commonly diagnosed (59%), followed by drug intoxication, opsoclonus-myoclonus ataxia syndrome, episodic ataxia, acute cerebellitis, cerebellar stroke, ADEM, meningitis, cerebral vein thrombosis, Leigh's disease, Miller-Fisher syndrome, and concussion. Among the patients with post-infectious cerebellar ataxia, 85% were 1-6 years old and all had a history of antecedent viral illness...
August 2016: Journal of Child Neurology
Adem Polat, Cengizhan Acikel, Betul Sozeri, Ismail Dursun, Ozgur Kasapcopur, Nesrin Gulez, Dogan Simsek, Mehmet Saldir, Ipek Dokurel, Hakan Poyrazoglu, Sevcan Bakkaloglu, Ali Delibas, Zelal Ekinci, Nuray A Ayaz, Yasar Kandur, Harun Peru, Yasemin G Kurt, Safiye R Polat, Erbil Unsal, Balahan Makay, Faysal Gok, Seza Ozen, Erkan Demirkaya
BACKGROUND: In this study, we examined the efficacy and safety of a once-daily dosage schema of colchicine compared with a twice-daily dosage schema in pediatric patients with familial Mediterranean fever (FMF). METHODS: In this 24-week, multicenter, randomized controlled noninferiority trial, pediatric patients newly diagnosed with FMF carrying a homozygous or compound heterozygous mutation and not receiving any treatment were included. Patients were randomly assigned using a block randomization method to receive treatment with a once- or twice-daily dosage...
2015: Arthritis Research & Therapy
Ramazan Kocaaslan, Yunus Kayalı, Adem Tok, Abdulkadir Tepeler
OBJECTIVE: To analyze the publication rates of full-text journal articles converted from the abstracts presented in the 22(nd) Turkish National Urology Congress in 2012. MATERIAL AND METHODS: A total of 576 abstracts accepted for presentation at the 22(nd) Turkish National Urology Association Meeting were identified from the published abstract book. The abstracts were categorized into subsections such as endourology and pediatric urology. The subsequent publication rate for the studies was evaluated by scanning PubMed Medline...
March 2016: Turkish Journal of Urology
Cynthia Beatty, Rachael A Bowler, Osman Farooq, Lindsay Dudeck, Deepa Ramasamy, E Ann Yeh, Robert Zivadinov, Bianca Weinstock-Guttman, Joy B Parrish
BACKGROUND: Acute disseminated encephalomyelitis (ADEM) is a demyelinating disorder that is usually self-limited. Recent studies have suggested ongoing neurological deficits and neurocognitive impairment in these patients. Little information on the correlation of clinical and neuroimaging markers in ADEM is available. We examined potential clinical factors (e.g., age of onset, acute symptom duration, magnetic resonance imaging [MRI] lesions) and their relation to neurocognitive and psychosocial outcomes...
April 2016: Pediatric Neurology
Soichiro Numa, Takashi Kasai, Takayuki Kondo, Yukie Kushimura, Ayaka Kimura, Hisashi Takahashi, Kanako Morita, Akihiro Tanaka, Yu-Ichi Noto, Tomoyuki Ohara, Masanori Nakagawa, Toshiki Mizuno
Acute disseminated encephalomyelitis (ADEM) followed by optic neuritis (ON) has been reported as a distinct phenotype associated with anti-myelin oligodendrocyte protein (MOG) antibody. We herein report the case of a 37-year-old woman who was diagnosed with ADEM at 4 years old of age and who subsequently developed ON followed by recurrent ADEM 33 years after the initial onset. A serum analysis showed anti-MOG antibody positivity. This phenotype has only previously been reported in pediatric cases. Neurologists thus need to be aware that the phenotype may occur in adult patients, in whom it may be assumed to be atypical multiple sclerosis...
2016: Internal Medicine
Hakan Bayir, Isa Yildiz, Murat Sereflican, Hamit Yoldas, Abdullah Demirhan, Adem D Kurt
No abstract text is available yet for this article.
November 2015: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Jennifer P Rubin
Investigators from Washington University School of Medicine and University of Florida College of Medicine, report that susceptibility-weight imaging (SWI) may be useful in differentiating initial presentation of pediatric multiple sclerosis (MS) from acute disseminated encephalomyelitis (ADEM).
February 2015: Pediatric neurology briefs
Patrick E Obermeier, Katharina Karsch, Christian Hoppe, Lea Seeber, Joanna Schneider, Susann Mühlhans, Xi Chen, Franziska Tief, Angela M Kaindl, Bernhard Weschke, Sindy Böttcher, Sabine Diedrich, Barbara Rath
BACKGROUND: Acute disseminated encephalomyelitis (ADEM) is an inflammatory, demyelinating disease occurring several weeks after viral infection. Enteroviruses have been described as potential triggers of ADEM, but the closely related parechoviruses have not. The objective of the study is to assess the prevalence and disease presentation of ADEM after parechovirus infection in a syndromic surveillance program for pediatric infection/inflammation of the central nervous system (CNS). METHODS: The surveillance was conducted at the Charité Department of Pediatrics in Berlin, Germany, from November 2010 to November 2014...
January 2016: Pediatric Infectious Disease Journal
Adem Yaşar, Yasemin Akın, Bülent Karadağ, Belma Yaşar, Mehmet Karacı
OBJECTIVE: To analyze the relationship between obesity and asthma control in a group of patients with asthma. METHODS: In this prospective study, body mass index (BMI) values of 200 asthma patients aged 4-18 y who had been regularly followed up by Kartal Education and Research Hospital Pediatric Asthma Outpatient Clinic were calculated. Asthma control test (ACT) and asthma control questionnaire (ACQ) were performed. The degrees of asthma control were evaluated with regard to BMI values in consideration of the data obtained...
June 2016: Indian Journal of Pediatrics
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