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breast cancer 3DCRT IMRT

Volker Rudat, Alaa Nour, Salam Abou Ghaida, Aziz Alaradi
BACKGROUND: The purpose of the study was to evaluate the impact of multiple prognostic factors on the acute skin reaction in adjuvant breast cancer radiotherapy, in particular the impact of hypofractionation (HF) compared to conventional fractionation (CF) and tangential beam (TB) IMRT compared to three-dimensional conformal radiotherapy (3DCRT). METHODS: Two-hundred and sixty-six breast cancer patients with postoperative radiotherapy after breast conserving surgery or mastectomy were retrospectively evaluated...
2016: Radiation Oncology
Emel Haciislamoglu, Fatma Colak, Emine Canyilmaz, Ahmet Yasar Zengin, Ahmet Hakan Yilmaz, Adnan Yoney, Zumrut Bahat
The aim of this study was to identify a rational strategy for the selection of multi-beam IMRT in patients with right breast cancer through the comparison of dosimetric parameters of the planning target volume (PTV) and organs at risk (OARs) using five different radiotherapy modalities. This was a retrospective study using computed tomography scans from ten patients with early-stage right breast cancer who had been treated previously. Three dimensional conformal radiotherapy (3DCRT), forward-planned IMRT (for-IMRT), inverse-planned IMRT (inv-IMRT), helical tomotherapy (HT), and volumetric-modulated arc therapy (VMAT) were planned for each patient...
2016: SpringerPlus
S Moorthy, H S Elhateer, Skd Majumdar, S Mohammed, R Patnaik
AIM OF STUDY: Breast conserving surgery (BCS) is the standard treatment for stage I and II breast cancer. Multiple studies have shown that recurrences after lumpectomy occur mainly in or near the tumor bed. Use of accelerated partial breast irradiation (APBI) allows for significant reduction in the overall treatment time that results in increasing patient compliance and decreasing healthcare costs. We conducted a treatment planning study to evaluate the role of intensity modulated radiation therapy (IMRT) with regards to three-dimensional conformal radiation therapy (3DCRT) in APBI...
January 2016: Indian Journal of Cancer
Felix Heggemann, Hanna Grotz, Grit Welzel, Christina Dösch, Jan Hansmann, Uta Kraus-Tiefenbacher, Ulrike Attenberger, Stephan Oswald Schönberg, Martin Borggrefe, Frederik Wenz, Theano Papavassiliu, Frank Lohr
PURPOSE: Breast intensity modulated radiation therapy (IMRT) reduces high-dose heart volumes but increases low-dose volumes. We prospectively assessed heart changes after 3D conformal RT (3DCRT) and IMRT for left-sided breast cancer. Heart dose was analyzed individually, 3DCRT patients were moderately exposed, and IMRT was performed only in patients with unacceptably high heart doses upon 3DCRT planning. METHODS AND MATERIALS: In 49 patients (38 patients received 3DCRT; 11 patients received IMRT; and 20 patients received neoadjuvant or adjuvant chemotherapy) magnetic resonance imaging (MRI) and echocardiography were performed before and at 6, 12, and 24 months after treatment...
November 15, 2015: International Journal of Radiation Oncology, Biology, Physics
Jackie Yim, Clare Suttie, Regina Bromley, Marita Morgia, Gillian Lamoury
INTRODUCTION: We report on a retrospective dosimetric study, comparing 3D conformal radiotherapy (3DCRT) and hybrid intensity modulated radiotherapy (hIMRT). We evaluated plans based on their planning target volume coverage, dose homogeneity, dose to organs at risk (OARs) and exposure of normal tissue to radiation. The Homogeneity Index (HI) was used to assess the dose homogeneity in the target region, and we describe a new index, the normal tissue index (NTI), to assess the dose in the normal tissue inside the tangent treatment portal...
September 2015: Journal of Medical Radiation Sciences
Changchun Ma, Wuzhe Zhang, Jiayang Lu, Lili Wu, Fangcai Wu, Baotian Huang, Yan Lin, Dongsheng Li
This study aimed to compare the post-modified radical mastectomy radiotherapy (PMRMRT) for left-sided breast cancer utilizing 3-dimensional conformal radiotherapy with field-in-field technique (3DCRT-FinF), 5-field intensity-modulated radiation therapy (5F-IMRT) and 2- partial arc volumetric modulated arc therapy (2P-VMAT). We created the 3 different PMRMRT plans for each of the ten consecutive patients. We performed Kruskal-Wallis analysis of variance (ANOVA) followed by the Dunn's-type multiple comparisons to establish a hierarchy in terms of plan quality and dosimetric benefits...
2015: Scientific Reports
Marianne C Aznar, Maja V Maraldo, Deborah A Schut, Michael Lundemann, N Patrik Brodin, Ivan R Vogelius, Anne K Berthelsen, Lena Specht, Peter M Petersen
PURPOSE: Hodgkin lymphoma (HL) survivors have an increased risk of cardiovascular disease (CD), lung cancer, and breast cancer. We investigated the risk for the development of CD and secondary lung, breast, and thyroid cancer after radiation therapy (RT) delivered with deep inspiration breath-hold (DIBH) compared with free-breathing (FB) using 3-dimensional conformal RT (3DCRT) and intensity modulated RT (IMRT). The aim of this study was to determine which treatment modality best reduced the combined risk of life-threatening late effects in patients with mediastinal HL...
May 1, 2015: International Journal of Radiation Oncology, Biology, Physics
Guang-Pei Chen, Feng Liu, Julia White, Frank A Vicini, Gary M Freedman, Douglas W Arthur, X Allen Li
This study compared the 7 treatment plan options in achieving the dose-volume criteria required by the Radiation Therapy Oncology Group (RTOG) 1005 protocol. Dosimetry plans were generated for 15 representative patients with early-stage breast cancer (ESBC) based on the protocol-required dose-volume criteria for each of the following 7 treatment options: 3D conformal radiotherapy (3DCRT), whole-breast irradiation (WBI) plus 3DCRT lumpectomy boost, 3DCRT WBI plus electron boost, 3DCRT WBI plus intensity-modulated radiation therapy (IMRT) boost, IMRT WBI plus 3DCRT boost, IMRT WBI plus electron boost, IMRT WBI plus IMRT boost, and simultaneous integrated boost (SIB) with IMRT...
2015: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
X Sharon Qi, Tian X Liu, Arthur K Liu, Francis Newman, Rachel Rabinovitch, Brian Kavanagh, Y Angie Hu
The 3-dimensional conformal radiotherapy (3DCRT) technique is the standard for breast cancer radiotherapy. During treatment planning, not only the coverage of the planning target volume (PTV) but also the minimization of the dose to critical structures, such as the lung, heart, and contralateral breast tissue, need to be considered. Because of the complexity and variations of patient anatomy, more advanced radiotherapy techniques are sometimes desired to better meet the planning goals. In this study, we evaluated external-beam radiation treatment techniques for left breast cancer using various delivery platforms: fixed-field including TomoDirect (TD), static intensity-modulated radiotherapy (sIMRT), and rotational radiotherapy including Elekta volumetric-modulated arc therapy (VMAT) and tomotherapy helical (TH)...
2014: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Sarah O S Osman, Sandra Hol, Philip M Poortmans, Marion Essers
PURPOSE: To investigate the effects of using volumetric modulated arc therapy (VMAT) and/or voluntary moderate deep inspiration breath-hold (vmDIBH) in the radiation therapy (RT) of left-sided breast cancer including the regional lymph nodes. MATERIALS AND METHODS: For 13 patients, four treatment combinations were compared; 3D-conformal RT (i.e., forward IMRT) in free-breathing 3D-CRT(FB), 3D-CRT(vmDIBH), 2 partial arcs VMAT(FB), and VMAT(vmDIBH). Prescribed dose was 42...
July 2014: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Lanea M M Keller, Randi Cohen, Dennis M Sopka, Tianyu Li, Linna Li, Penny R Anderson, Barbara L Fowble, Gary M Freedman
PURPOSE: Large breast size presents special problems during radiation simulation, planning, and patient treatment, including increased skin toxicity, in women undergoing breast-conserving surgery and radiation therapy (BCT). We report our experience using a bra during radiation in large-breasted women and its effect on acute toxicity and heart and lung dosimetry. METHODS AND MATERIALS: From 2001 to 2006, 246 consecutive large-breasted women (bra size ≥38 or ≥D cup) were treated with BCT using either 3-dimensional conformal radiation therapy (3DCRT) or intensity modulated radiation therapy (IMRT)...
January 2013: Practical Radiation Oncology
Neil K Taunk, Robert G Prosnitz
PURPOSE: In women with unfavorable thoracic anatomy undergoing left breast radiation therapy (RT) after breast-conserving surgery, a significant volume of the heart may receive high-dose radiation, which has been shown previously to be associated with increased late cardiac morbidity and mortality. Use of intensity modulated radiation therapy (IMRT) has been proposed to reduce cardiac dose in these patients. We compared cardiac exposure from IMRT delivered from 2 opposed fields and 3-dimensional conformal radiation therapy (3DCRT) plans employing simple heart blocks...
October 2012: Practical Radiation Oncology
Xinhong Wu, Bo Luo, Shaozhong Wei, Yan Luo, Yaojun Feng, Juan Xu, Wei Wei
AIM: To investigate the treatment efficiency of whole brain irradiation combined with precise radiotherapy on triple-negative (TN) phenotype breast cancer patients with brain metastases and their survival times. MATERIALS AND METHODS: A total of 112 metastatic breast cancer patients treated with whole brain irradiation and intensity modulated radiotherapy (IMRT) or 3D conformal radiotherapy (3DCRT) were analyzed. Thirty-seven patients were of TN phenotype. Objective response rates were compared...
November 2013: Journal of Cancer Research and Therapeutics
Tejinder Kataria, Shyam Singh Bisht, Deepak Gupta, Shikha Goyal, Kannan Jassal, Ashu Abhishek, Kuldeep Sharma, Puneet Pareek, Vikash Kumar, Sandeep Jain, Manoj Tayal, N Karthikeyan
PURPOSE: To analyze incidental radiation doses to minimally dissected axilla with Intensity modulated radiotherapy (IMRT), 3D conformal radiotherapy (3DCRT) and standard tangents (ST). METHODS & MATERIALS: We prospectively evaluated incidental radiation to axilla in fifty cases of early breast cancer treated with breast conservation surgery with sentinel node biopsy alone followed by whole breast irradiation with IMRT. Three plans were devised for each CT dataset, comprising ST, 3DCRT and IMRT tangents...
December 2013: Breast: Official Journal of the European Society of Mastology
Natalie Xu, Meng Wei Ho, Zuofeng Li, Christopher G Morris, Nancy P Mendenhall
OBJECTIVES: Regional node irradiation in patients with invasive breast cancer often results in increased radiation exposure to organs at risk. We evaluated the potential advantages of 3-dimensional conformal photon+proton therapy (3DCX+PT) in treating regional nodes versus photon-electron (3DCRT) or intensity-modulated radiotherapy (IMRT). MATERIALS AND METHODS: Ten left-sided breast cancer patients underwent radiation treatment planning. 3DCX+PT, 3DCRT, and IMRT plans were generated for each patient...
December 2014: American Journal of Clinical Oncology
Andreas Joosten, Oscar Matzinger, Wendy Jeanneret-Sozzi, François Bochud, Raphaël Moeckli
BACKGROUND AND PURPOSE: To make a comprehensive evaluation of organ-specific out-of-field doses using Monte Carlo (MC) simulations for different breast cancer irradiation techniques and to compare results with a commercial treatment planning system (TPS). MATERIALS AND METHODS: Three breast radiotherapy techniques using 6MV tangential photon beams were compared: (a) 2DRT (open rectangular fields), (b) 3DCRT (conformal wedged fields), and (c) hybrid IMRT (open conformal+modulated fields)...
January 2013: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Valeria Casanova Borca, Pierfrancesco Franco, Paola Catuzzo, Fernanda Migliaccio, Flora Zenone, Stefania Aimonetto, Andrea Peruzzo, Massimo Pasquino, Giuliana Russo, Maria Rosa La Porta, Domenico Cante, Piera Sciacero, Giuseppe Girelli, Umberto Ricardi, Santi Tofani
BACKGROUND: This study investigates the use of TomoDirect™ 3DCRT for whole breast adjuvant radiotherapy (AWBRT) that represents a very attractive treatment opportunity, mainly for radiotherapy departments without conventional Linacs and only equipped with helical tomotherapy units. METHODS: Plans were created for 17 breast cancer patients using TomoDirect in 3DCRT and IMRT modality and field-in-field 3DCRT planning (FIF) and compared in terms of PTV coverage, overdosage, homogeneity, conformality and dose to OARs...
2012: Radiation Oncology
Fuli Zhang, Mingmin Zheng
INTRODUCTION: The use of conservative surgery combined with whole-breast irradiation (WBI) has been established as a valid alternative to mastectomy for the management of early-stage breast cancer. The aim of this study was to compare dosimetric parameters of the planning target volume(PTV) and organs at risk (OARs) between conventional radiation therapy (CR), 3-D conformal radiation therapy (3DCRT), and direct machine parameter optimisation intensity-modulated radiation therapy (DMPO-IMRT) after breast-conserving surgery...
December 2011: Journal of Medical Imaging and Radiation Oncology
Rajni A Sethi, Hyun Soo No, Gabor Jozsef, Jane P Ko, Silvia C Formenti
BACKGROUND AND PURPOSE: To determine the optimal method of targeting breast and regional nodes in selected breast cancer patients after axillary dissection, we compared the results of IMRT versus no IMRT, and CT-informed versus clinically-placed fields, in supine and prone positions. MATERIALS AND METHODS: Twelve consecutive breast cancer patients simulated both prone and supine provided the images for this study. Four techniques were used to target breast, level III axilla, and supraclavicular fossa in either position: a traditional three-field three-dimensional conformal radiotherapy (3DCRT) plan, a four-field 3DCRT plan using a posterior axillary boost field, and two techniques using a CT-informed target volume consisting of an optimized 3DCRT plan (CT-planned 3D) and an intensity-modulated radiotherapy (IMRT) plan...
January 2012: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Julia R White, John L Meyer
Intensity-modulated radiotherapy (IMRT) can improve dose distributions through the treated breast and also reduce radiation doses to adjacent normal tissues including the contralateral breast, heart and lung with appropriate planning. Analyses demonstrate that the quality of radiation dose distribution does affect clinical results, and that outcomes are enhanced through improved planning and dose delivery methods. To achieve these results, it is essential to carefully define tissue volumes for treatment or avoidance, select technologies that can potentially conform fields to those volumes, use comprehensive planning methods, and assess their results in terms of objective dose constraints...
2011: Frontiers of Radiation Therapy and Oncology
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