keyword
https://read.qxmd.com/read/35694899/beyond-colonoscopy-physical-activity-as-a-viable-adjunct-to-prevent-of-colorectal-cancer
#21
REVIEW
Wei-Yuan Chang, Han-Mo Chiu
Colorectal cancer (CRC) is a common cancer with an increasing incidence worldwide. The implementation of mass screening program has been proven effective in reducing the global burden of CRC but its effectiveness is not ideal and some metabolic derangements and lifestyle factors were reported to be attributable for such a deficit. Implementing positive lifestyle intervention as primary prevention therefore becomes critical because colorectal carcinogenesis can be promoted by several lifestyle factors, such as lack of physical activity...
June 13, 2022: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://read.qxmd.com/read/35411222/screening-of-early-staged-colorectal-neoplasia-by-clonal-hematopoiesis-based-liquid-biopsy-and-machine-learning
#22
JOURNAL ARTICLE
Yin-Chen Hsu, Sin-Ming Huang, Li-Chun Chang, Yan-Ming Chen, Ya-Hsuan Chang, Jing-Wei Lin, Chien-Chia Lin, Ching-Wen Chen, Hsuan-Yu Chen, Han-Mo Chiu, Sung-Liang Yu
Liquid biopsy test has a better uptake for colorectal cancer (CRC) screening. However, suboptimal detection of early-staged colorectal neoplasia (CRN) limits its application. Here, we established an early-staged CRN blood test using error-corrected sequencing by comparing clonal hematopoiesis (CH) of 63 CRN patients and that of 32 controls. We identified 1,446 variants and classified the uniqueness in CRN patients. There was no significance difference in the amount of variant between CRNs and controls, but the uniqueness of variants with defective DNA mismatch repair-related mutational signature was addressed from peripheral blood in early-staged CRN patients...
2022: American Journal of Cancer Research
https://read.qxmd.com/read/35134176/association-of-incidence-of-acid-related-upper-gastrointestinal-disorders-with-glycated-hemoglobin-level
#23
JOURNAL ARTICLE
Ping-Huei Tseng, Chi-Sheng Hung, Chia-Hung Tu, Chien-Chuan Chen, Wan-Chung Liao, Yi-Chia Lee, Han-Mo Chiu, Wei-Shiung Yang, Ming-Shiang Wu
CONTEXT: Previous cross-sectional studies show diabetes and higher levels of plasma hemoglobin A1c (HbA1c) are associated with a higher prevalence of gastrointestinal (GI) complications. However, whether the glycemic status is associated with incident acid-related upper GI disorders remains unclear. OBJECTIVE: We aimed to determine the effect of hyperglycemia per se, in terms of HbA1c, on the incidence of acid-related disorders. METHODS: We analyzed consecutive subjects who had undergone repeated upper endoscopies as part of the health examinations at the National Taiwan University Hospital from 2005 to 2011...
May 17, 2022: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/35122323/efficacy-of-international-web-based-educational-intervention-in-the-detection-of-high-risk-flat-and-depressed-colorectal-lesions-higher-catch-project-with-a-video-randomized-trial
#24
RANDOMIZED CONTROLLED TRIAL
Mineo Iwatate, Daizen Hirata, Carlos Paolo D Francisco, Jonard Tan Co, Jeong-Sik Byeon, Neeraj Joshi, Rupa Banerjee, Duc Trong Quach, Than Than Aye, Han-Mo Chiu, Louis H S Lau, Siew C Ng, Tiing Leong Ang, Supakij Khomvilai, Xiao-Bo Li, Shiaw-Hooi Ho, Wataru Sano, Santa Hattori, Mikio Fujita, Yoshitaka Murakami, Masaaki Shimatani, Yuzo Kodama, Yasushi Sano
OBJECTIVES: Three subcategories of high-risk flat and depressed lesions (FDLs), laterally spreading tumors non-granular type (LST-NG), depressed lesions, and large sessile serrated lesions (SSLs), are highly attributable to post-colonoscopy colorectal cancer (CRC). Efficient and organized educational programs on detecting high-risk FDLs are lacking. We aimed to explore whether a web-based educational intervention with training on FIND clues (fold deformation, intensive stool/mucus attachment, no vessel visibility, and demarcated reddish area) may improve the ability to detect high-risk FDLs...
September 2022: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://read.qxmd.com/read/35048427/synergistic-or-independent-revisiting-colonoscopic-surveillance-for-conventional-and-serrated-lesions
#25
EDITORIAL
Wei-Yuan Chang, Han-Mo Chiu
No abstract text is available yet for this article.
January 20, 2022: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://read.qxmd.com/read/34918781/mild-chronic-colitis-triggers-parkinsonism-in-lrrk2-mutant-mice-through-activating-tnf-%C3%AE-pathway
#26
JOURNAL ARTICLE
Chin-Hsien Lin, Han-Yi Lin, En-Pong Ho, Yi-Ci Ke, Mei-Fang Cheng, Chyng-Yann Shiue, Chi-Han Wu, Peng-Hsiang Liao, Angela Yu-Huey Hsu, Li-An Chu, Ya-Ding Liu, Ya-Hui Lin, Yi-Cheng Tai, Chia-Tung Shun, Han-Mo Chiu, Ming-Shiang Wu
BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) is a common risk gene for Parkinson's disease (PD) and inflammatory bowel disorders. However, the penetrance of the most prevalent LRRK2 mutation, G2019S, is <50%. Factors other than genetic mutations are needed in PD process. OBJECTIVES: To examine whether and how gut inflammation may act as an environmental trigger to neurodegeneration in PD. METHODS: A mild and chronic dextran sodium sulfate (DSS)-induced colitis mice model harboring LRRK2 G2019S mutation was established...
December 17, 2021: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/34867827/obesity-exacerbates-irritable-bowel-syndrome-related-sleep-and-psychiatric-disorders-in-women-with-polycystic-ovary-syndrome
#27
JOURNAL ARTICLE
Ping-Huei Tseng, Han-Mo Chiu, Chia-Hung Tu, Ming-Shiang Wu, Hong-Nerng Ho, Mei-Jou Chen
Background/Objectives: Polycystic ovary syndrome (PCOS) and irritable bowel syndrome (IBS) share similar clinical and psychosocial features. We aimed to investigate the clinical characteristics of IBS in women with PCOS, and its relationship with obesity, metabolic and hormonal profiles, as well as sleep and psychiatric disorders. Subjects/Methods: This is a cross-sectional case-control study of 431 untreated women with PCOS and 259 healthy volunteers. All participants were assessed with a comprehensive clinical evaluation and two questionnaires: the Athens Insomnia Scale (AIS) and the Brief Symptom Rating Scale (BSRS-5)...
2021: Frontiers in Endocrinology
https://read.qxmd.com/read/34801021/overbooking-for-physical-examination-considering-late-cancellation-and-set-resource-relationship
#28
JOURNAL ARTICLE
Te-Wei Ho, Ling-Chieh Kung, Hsin-Ya Huang, Jui-Fen Lai, Han-Mo Chiu
BACKGROUND: Late cancellations of physical examination has severe impact on the operations of a physical examination center since it is often too late to fill vacancy. A booking control policy that considers overbooking is then one natural solution. Unlike appointment scheduling problems for clinics and hospitals, in which treating a patient mostly requires only one type of resource, a physical examination set typically requires multiple types of resources. Traditional methods that do not consider set-resource relationship thus may be inapplicable...
November 20, 2021: BMC Health Services Research
https://read.qxmd.com/read/34589434/exploration-of-the-proteomic-landscape-of-small-extracellular-vesicles-in-serum-as-biomarkers-for-early-detection-of-colorectal-neoplasia
#29
JOURNAL ARTICLE
Li-Chun Chang, Yi-Chiung Hsu, Han-Mo Chiu, Koji Ueda, Ming-Shiang Wu, Chiun-How Kao, Tang-Long Shen
Background: Patient participation in colorectal cancer (CRC) screening via a stool test and colonoscopy is suboptimal, but participation can be improved by the development of a blood test. However, the suboptimal detection abilities of blood tests for advanced neoplasia, including advanced adenoma (AA) and CRC, limit their application. We aimed to investigate the proteomic landscape of small extracellular vesicles (sEVs) from the serum of patients with colorectal neoplasia and identify specific sEV proteins that could serve as biomarkers for early diagnosis...
2021: Frontiers in Oncology
https://read.qxmd.com/read/34525876/association-of-ambient-fine-particulate-matter-pm-2-5-with-elevated-fecal-hemoglobin-concentration-and-colorectal-carcinogenesis-a-population-based-retrospective-cohort-study
#30
JOURNAL ARTICLE
Mei-Sheng Ku, Chen-Yu Liu, Chen-Yang Hsu, Han-Mo Chiu, Hsiu-Hsi Chen, Chang-Chuan Chan
The roles of ambient fine particulate matter (PM2.5 ) in the prevention of colorectal cancer (CRC) have been scarcely highlighted as there is short of empirical evidence regarding the influences of PM2.5 on multistep carcinogenic processes of CRC. A retrospective cohort design with multistate outcomes was envisaged by linking monthly average PM2.5 concentrations at 22 city/county level with large-scale cohorts of cancer-screened population to study the influences of PM2.5 on short-term inflammatory process and multistep carcinogenic processes of CRC...
January 2021: Cancer Control: Journal of the Moffitt Cancer Center
https://read.qxmd.com/read/34516690/active-exercise-after-polypectomy-reduces-the-risk-of-metachronous-advanced-colorectal-neoplasm
#31
JOURNAL ARTICLE
Wei-Yuan Chang, Hsuan-Ho Lin, Li-Chun Chang, Wen-Feng Hsu, Ming-Shiang Wu, Han-Mo Chiu
BACKGROUND AND STUDY AIMS: Exercise is associated with a lower risk of colorectal neoplasm but its association with metachronous advanced colorectal neoplasm development after polypectomy remains unclear. We aimed to investigate associations between subjects' exercise habits and the risk of metachronous advanced colorectal neoplasm. PATIENTS AND METHODS: This study analyzed subjects older than 40 years who received screening colonoscopy with polypectomy and surveillance colonoscopy between January 2009 and December 2016...
September 13, 2021: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://read.qxmd.com/read/34499911/bringing-primary-and-secondary-prevention-into-play-in-community-prevention-of-gastrointestinal-cancers
#32
EDITORIAL
Han-Mo Chiu
No abstract text is available yet for this article.
September 6, 2021: Gastroenterology
https://read.qxmd.com/read/34351014/can-iee-improve-adr
#33
REVIEW
Wei-Yuan Chang, Han-Mo Chiu
An accumulating body of evidence has shown that detection and resection of pre-cancerous adenoma by colonoscopy could effectively prevent colorectal cancer (CRC) and its related mortality. Among various colonoscopy quality indicators, such as cecal intubation rate, withdrawal time, and adenoma detection rate (ADR), ADR is the most important one and most closely associated with the subsequent risk of CRC. Image-enhanced endoscopy (IEE), including digital and dye-based IEE, was originally developed to discriminate neoplastic from non-neoplastic lesions but later studies have demonstrated that it can also enhance lesion detection by enhancing the contrast between the lesion and background colonic mucosa...
August 5, 2021: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://read.qxmd.com/read/34287049/targeted-long-read-sequencing-reveals-comprehensive-architecture-burden-and-transcriptional-signatures-from-hbv-associated-integrations-and-translocations-in-hcc-cell-lines
#34
JOURNAL ARTICLE
Ricardo Ramirez, Nicholas van Buuren, Lindsay Gamelin, Cameron Soulette, Lindsey May, Dong Han, Mei Yu, Regina Choy, Guofeng Cheng, Neeru Bhardwaj, Joy Chiu, Robert C Muench, William E Delaney, Hongmei Mo, Becket Feierbach, Li Li
Hepatitis B virus (HBV) can integrate into the chromosomes of infected hepatocytes, creating potentially oncogenic lesions that can lead to hepatocellular carcinoma (HCC). However, our current understanding of integrated HBV DNA architecture, burden and transcriptional activity is incomplete due to technical limitations. A combination of genomics approaches was used to describe HBV integrations and corresponding transcriptional signatures in three HCC cell lines: huH-1, PLC/PRF/5 and Hep3B. To generate high coverage long-read sequencing data, a custom panel of HBV-targeting biotinylated oligonucleotide probes was designed...
July 21, 2021: Journal of Virology
https://read.qxmd.com/read/34263484/obesity-metabolic-derangement-and-the-risk-of-colorectal-neoplasm
#35
EDITORIAL
Han-Mo Chiu
No abstract text is available yet for this article.
July 2021: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/34217416/modelling-the-impacts-of-covid-19-pandemic-on-the-quality-of-population-based-colorectal-cancer-screening
#36
JOURNAL ARTICLE
Grace Hsiao-Hsuan Jen, Amy Ming-Fang Yen, Chen-Yang Hsu, Han-Mo Chiu, Sam Li-Sheng Chen, Tony Hsiu-Hsi Chen
COVID-19 pandemic has severely affected regular public health interventions including population-based cancer screening. Impacts of such screening delays on the changes in structure and screening process and the resultant long-term outcomes are unknown. It is therefore necessary to develop a systematic framework to assess theses impacts related to these components of quality. Using population-based cancer screening with fecal immunochemical test (FIT) as an illustration, the main analysis was to assess how various scenarios of screening delays were associated with the capacity for primary screening and full time equivalent (FTE) for colonoscopy and impact long-term outcomes based on a Markov decision tree model on population level...
October 2021: Preventive Medicine
https://read.qxmd.com/read/34044024/mitigating-the-impact-of-covid-19-on-colorectal-cancer-screening-organized-service-screening-perspectives-from-the-asia-pacific-region
#37
JOURNAL ARTICLE
Han-Mo Chiu, Chiu-Wen Su, Weng-Feng Hsu, Grace Hsiao-Hsuan Jen, Chen-Yang Hsu, Sam Li-Sheng Chen, Hsiu-Hsi Chen
Colorectal cancer(CRC) is one of the most prevalent malignancies in the Asia-Pacific region, and many countries in this region have launched population CRC service screening. In this study, CRC screening key indicators, including the FIT(fecal immunochemical test) screening rate (or participation rate) and the rate of undergoing colonoscopy after positive FIT in 2019 and 2020, were surveyed in individual countries in the Asia-Pacific region. The impact of the pandemic on the effectiveness of CRC screening was simulated given different screening rates and colonoscopy rates and assuming the pandemic would persist or remain poorly controlled for a long period of time, using the empirical data from the Taiwanese program and the CRC natural history model...
October 2021: Preventive Medicine
https://read.qxmd.com/read/33955121/recurrence-outcomes-less-favorable-in-t1-rectal-cancer-than-in-t1-colon-cancer
#38
JOURNAL ARTICLE
Li-Chun Chang, Chia-Tung Shun, Been-Ren Lin, Silvia Sanduleanu, Weng-Feng Hsu, Ming-Shiang Wu, Han-Mo Chiu
BACKGROUND: With the implementation of screening programs worldwide, diagnosis of early-stage colorectal cancer steadily increased, including T1 cancer. Current T1 cancer treatment does not differ according to anatomic location. We therefore compared the disease-free survival of T1 cancer arising from the rectum versus the colon. METHODS: The hospital-based study included subjects with T1 cancer at National Taiwan University Hospital from 2005 to 2014. Clinical, colonoscopy, and histopathology were reviewed for patients with a mean follow-up time of 7...
September 2021: Oncologist
https://read.qxmd.com/read/33840731/letter-to-the-editor-in-response-to-endoscopic-recognition-and-management-strategies-for-malignant-colorectal-polyps-recommendations-of-the-us-multi-society-task-force-on-colorectal-cancer
#39
COMMENT
Roy Soetikno, Han Mo Chiu, Ravishankar Asokkumar, Silvia Sanduleanu, Shinji Tanaka, Amit Rastogi, Noriya Uedo, Hazem Hammad, George Triadafilopoulos
No abstract text is available yet for this article.
July 1, 2021: American Journal of Gastroenterology
https://read.qxmd.com/read/33624890/application-of-artificial-intelligence-in-gastroenterology-potential-role-in-clinical-practice
#40
JOURNAL ARTICLE
Chen-Ya Kuo, Han-Mo Chiu
Artificial intelligence (AI) based on deep learning boosted medical research in the past years and is expected to enormously change the style of health care in many aspects in the foreseeable future. Nowadays, there are exploding volumes of healthcare-related data being generated daily. Because of its time-sensitive characteristics, being able to process large amounts of data in real-time fashion is crucial in healthcare settings. In gastroenterology practice, AI can manage and interpret the sheer amount of data with different formats coming from a myriad of sources, including currently used endoscopic or imaging devices, digital record systems, and electronic health records, or from other sources such as governmental databases, social media, or wearable devices over a long period...
February 2021: Journal of Gastroenterology and Hepatology
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